lethal dose 50

Summary

Summary: The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population.

Top Publications

  1. ncbi Aquatic toxicity of cartap and cypermethrin to different life stages of Daphnia magna and Oryzias latipes
    YoungHee Kim
    School of Public Health, Seoul National University, Seoul, Korea
    J Environ Sci Health B 43:56-64. 2008
  2. ncbi Acute and chronic toxicity of imidacloprid to the aquatic invertebrates Chironomus tentans and Hyalella azteca under constant- and pulse-exposure conditions
    Sarah J Stoughton
    Toxicology Centre, University of Saskatchewan, 44 Campus Drive, S7N 5B3, Saskatoon, SK, Canada
    Arch Environ Contam Toxicol 54:662-73. 2008
  3. ncbi Laboratory evaluation of a phytosteroid compound of mature leaves of Day Jasmine (Solanaceae: Solanales) against larvae of Culex quinquefasciatus (Diptera: Culicidae) and nontarget organisms
    Anupam Ghosh
    Department of Zoology, The University of Burdwan, Burdwan, 713104, West Bengal, India
    Parasitol Res 103:271-7. 2008
  4. ncbi Efficacy and efficiency of new Bacillus thuringiensis var israelensis and Bacillus sphaericus formulations against Afrotropical anophelines in Western Kenya
    Ulrike Fillinger
    International Centre of Insect Physiology and Ecology ICIPE, Mbita Point, Kenya
    Trop Med Int Health 8:37-47. 2003
  5. pmc Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population
    Marco Vignuzzi
    Department of Microbiology and Immunology, University of California, San Francisco, California 94143 2280, USA
    Nature 439:344-8. 2006
  6. ncbi Role of quorum sensing in the pathogenicity of Burkholderia pseudomallei
    Ricky L Ulrich
    Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702 5011, USA
    J Med Microbiol 53:1053-64. 2004
  7. ncbi Comparison of nanosilver and ionic silver toxicity in Daphnia magna and Pimephales promelas
    Sarah M Hoheisel
    U S Environmental Protection Agency, Mid Continent Ecology Division, Duluth, MN, USA
    Environ Toxicol Chem 31:2557-63. 2012
  8. ncbi Analyzing effects of pesticides on invertebrate communities in streams
    Matthias Liess
    UFZ Centre for Environmental Research, Permoserstrasse 15, D 04318 Leipzig, Germany
    Environ Toxicol Chem 24:954-65. 2005
  9. ncbi Comparative toxicity study of Ag, Au, and Ag-Au bimetallic nanoparticles on Daphnia magna
    Ting Li
    BCPS Department, Illinois Institute of Technology, 3101 South Dearborn Street, Chicago, IL 60616, USA
    Anal Bioanal Chem 398:689-700. 2010
  10. ncbi Acute and subacute toxicity studies of Aegle marmelos Corr., an Indian medicinal plant
    A Veerappan
    Department of Pharmacology and Environmental Toxicology, Dr A L M Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, Tamil Nadu, India
    Phytomedicine 14:209-15. 2007

Detail Information

Publications235 found, 100 shown here

  1. ncbi Aquatic toxicity of cartap and cypermethrin to different life stages of Daphnia magna and Oryzias latipes
    YoungHee Kim
    School of Public Health, Seoul National University, Seoul, Korea
    J Environ Sci Health B 43:56-64. 2008
    ..Ecological hazard assessments of long-term low dose or pulsed exposures to cartap and cypermethrin may reveal more realistic consequences of these compounds in surface water...
  2. ncbi Acute and chronic toxicity of imidacloprid to the aquatic invertebrates Chironomus tentans and Hyalella azteca under constant- and pulse-exposure conditions
    Sarah J Stoughton
    Toxicology Centre, University of Saskatchewan, 44 Campus Drive, S7N 5B3, Saskatoon, SK, Canada
    Arch Environ Contam Toxicol 54:662-73. 2008
    ....
  3. ncbi Laboratory evaluation of a phytosteroid compound of mature leaves of Day Jasmine (Solanaceae: Solanales) against larvae of Culex quinquefasciatus (Diptera: Culicidae) and nontarget organisms
    Anupam Ghosh
    Department of Zoology, The University of Burdwan, Burdwan, 713104, West Bengal, India
    Parasitol Res 103:271-7. 2008
    ..diurnum revealed the presence of many bioactive phytochemicals. The bioassay experiment with the third-instar larval form established that the presence of a steroid compound (R (f), 0.67) was responsible for mosquitocidal activity...
  4. ncbi Efficacy and efficiency of new Bacillus thuringiensis var israelensis and Bacillus sphaericus formulations against Afrotropical anophelines in Western Kenya
    Ulrike Fillinger
    International Centre of Insect Physiology and Ecology ICIPE, Mbita Point, Kenya
    Trop Med Int Health 8:37-47. 2003
    ....
  5. pmc Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population
    Marco Vignuzzi
    Department of Microbiology and Immunology, University of California, San Francisco, California 94143 2280, USA
    Nature 439:344-8. 2006
    ..Our study provides direct evidence for a fundamental prediction of the quasispecies theory and establishes a link between mutation rate, population dynamics and pathogenesis...
  6. ncbi Role of quorum sensing in the pathogenicity of Burkholderia pseudomallei
    Ricky L Ulrich
    Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702 5011, USA
    J Med Microbiol 53:1053-64. 2004
    ..pseudomallei. The findings of the investigation demonstrate that B. pseudomallei encodes multiple luxIR genes, and disruption of the QS alleles reduces animal pathogenicity, but does not affect exoproduct secretion...
  7. ncbi Comparison of nanosilver and ionic silver toxicity in Daphnia magna and Pimephales promelas
    Sarah M Hoheisel
    U S Environmental Protection Agency, Mid Continent Ecology Division, Duluth, MN, USA
    Environ Toxicol Chem 31:2557-63. 2012
    ..This in turn suggests that regulatory approaches based on the toxicity of ionic silver to aquatic life would not be underprotective for environmental releases of nanosilver...
  8. ncbi Analyzing effects of pesticides on invertebrate communities in streams
    Matthias Liess
    UFZ Centre for Environmental Research, Permoserstrasse 15, D 04318 Leipzig, Germany
    Environ Toxicol Chem 24:954-65. 2005
    ..The results emphasize the importance of considering ecological traits and recolonization processes on the landscape level for ecotoxicological risk assessment...
  9. ncbi Comparative toxicity study of Ag, Au, and Ag-Au bimetallic nanoparticles on Daphnia magna
    Ting Li
    BCPS Department, Illinois Institute of Technology, 3101 South Dearborn Street, Chicago, IL 60616, USA
    Anal Bioanal Chem 398:689-700. 2010
    ....
  10. ncbi Acute and subacute toxicity studies of Aegle marmelos Corr., an Indian medicinal plant
    A Veerappan
    Department of Pharmacology and Environmental Toxicology, Dr A L M Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, Tamil Nadu, India
    Phytomedicine 14:209-15. 2007
    ..Collectively, these data demonstrate that the extracts of the leaves of A. marmelos have a high margin of drug safety...
  11. ncbi Activation of Shiga toxin type 2d (Stx2d) by elastase involves cleavage of the C-terminal two amino acids of the A2 peptide in the context of the appropriate B pentamer
    Angela R Melton-Celsa
    Department of Microbiology, Uniformed Services University of the Health Sciences, F Edward Hebert School of Medicine, 4301 Jones Bridge Road, Bethesda, MD 20814 4799, USA
    Mol Microbiol 43:207-15. 2002
    ..that produce the activatable Stx2d are more virulent in a streptomycin (str)-treated mouse model of infection [lethal dose 50% (LD50) = 101] than are E. coli strains that produce any other type of Stx (LD50 = 1010)...
  12. ncbi Acute systemic toxicity--prospects for tiered testing strategies
    P A Botham
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK
    Toxicol In Vitro 18:227-30. 2004
    ..However, the total replacement of animal tests requires a considerable amount of further test development, followed by validation, and is at least 10 years away...
  13. pmc TetR is a positive regulator of the tetanus toxin gene in Clostridium tetani and is homologous to botR
    J C Marvaud
    Unité des Toxines Microbiennes, Institut Pasteur, 75724 Paris Cedex 15, France
    Infect Immun 66:5698-702. 1998
    ..This supports that TetR positively regulates the TeTx gene in C. tetani and that a conserved mechanism of regulation of the neurotoxin genes is involved in C. tetani and C. botulinum...
  14. ncbi Structural and functional properties of BaTX, a new Lys49 phospholipase A2 homologue isolated from the venom of the snake Bothrops alternatus
    Luis Alberto Ponce-Soto
    Biochemistry Department, Institute of Biology, Medical Sciences Faculty, State University of Campinas UNICAMP, Campinas, SP, Brazil
    Biochim Biophys Acta 1770:585-93. 2007
    ..Thus, the combined structural and functional information obtained identify BaTX as a new member of the K49 PLA(2) family, which presents the typical bioactivities described for such proteins...
  15. ncbi Resistance and cross-resistance to neonicotinoid insecticides and spinosad in the Colorado potato beetle, Leptinotarsa decemlineata (Say) (Coleoptera: Chrysomelidae)
    David Mota-Sanchez
    Department of Entomology, Michigan State University, East Lansing, MI 48824, USA
    Pest Manag Sci 62:30-7. 2006
    ..Rotation with spinosad also carries some risk, but it is unlikely that spinosad resistance in this case is mechanistically related to that for the neonicotinoids...
  16. ncbi Comparison of five methods for measuring sediment toxicity of hydrophobic contaminants
    Yiping Xu
    Department of Environmental Sciences, University of California, Riverside, California 92521, USA
    Environ Sci Technol 41:8394-9. 2007
    ..These results indicate thatthe use of C(free) reduces uncertainties caused by sediment variables such as OC properties and aging effects...
  17. ncbi Cross-resistance potential of fipronil in Musca domestica
    Michael Kristensen
    Danish Pest Infestation Laboratory, DK 2800, Kgs Lyngby, Denmark
    Pest Manag Sci 60:894-900. 2004
    ....
  18. ncbi Comparative toxicity of cadmium, zinc, and mixtures of cadmium and zinc to daphnids
    Joseph R Shaw
    Dartmouth College, Department of Biology, 103 Gilman Hall, Hanover, New Hampshire 03755, USA
    Environ Toxicol Chem 25:182-9. 2006
    ..Multimetal tests with D. magna did not differ from additive. Collectively, these studies suggest that D. magna may not be representative of other cladocerans...
  19. ncbi Effects of temperature on the sensitivity of sludge worm Tubifex tubifex Müller to selected heavy metals
    Rashmi Singh Rathore
    Ecotoxicology Division, Industrial Toxicology Research Centre, Mahatma Gandhi Marg, Post Box 80, Lucknow 226 001, India
    Ecotoxicol Environ Saf 53:27-36. 2002
    ..Influence of temperature on the short- and long-term toxicity of chemicals should be considered for establishing appropriate water-quality criteria and standards to protect aquatic flora and fauna and human health...
  20. ncbi Implementing Lecane quadridentata acute toxicity tests to assess the toxic effects of selected metals (Al, Fe and Zn)
    Félix Torres Guzmán
    Universidad Autonoma de Guerrero, Departamento de Quimica, Avenida Lázaro Cárdenas s n, Ciudad Universitaria, Chilpancingo 39660, Gro México
    Ecotoxicol Environ Saf 73:287-95. 2010
    ..12 mg L(-1)) making it the most toxic metal for L. quadridentata. This approach can be applied to other sites with similar concentrations of these metals...
  21. ncbi Safety of high volume lipid emulsion infusion: a first approximation of LD50 in rats
    David B Hiller
    Department of Anesthesiology, University of Illinois College of Medicine at Chicago, IL 60612, USA
    Reg Anesth Pain Med 35:140-4. 2010
    ..We hypothesize that high volumes of lipid could have undesirable effects and sought to identify the dose required to kill 50% of the animals (LD(50)) of large volume lipid administration...
  22. ncbi Toxicity studies of cremophor-free paclitaxel solid dispersion formulated by a supercritical antisolvent process
    Jae Hyun Park
    College of Pharmacy, Sungkyunkwan University, Suwon, 440 746, Korea
    Arch Pharm Res 32:139-48. 2009
    ....
  23. pmc Variability in the dynamics of mortality and immobility responses of freshwater arthropods exposed to chlorpyrifos
    Mascha N Rubach
    Department of Aquatic Ecology and Water Quality Management, Wageningen University and Research Centre, 6700AA Wageningen, The Netherlands
    Arch Environ Contam Toxicol 60:708-21. 2011
    ..This is even more relevant because an immobile animal is unlikely to survive for long periods under field conditions. This and other such considerations relevant to the decision-making process for a particular end point are discussed...
  24. ncbi A comparative study on the relationship between acetylcholinesterase activity and acute toxicity in Daphnia magna exposed to anticholinesterase insecticides
    Liane Biehl Printes
    Division of Zoology, School of Animal and Microbial Sciences, University of Reading, Whiteknights, P O Box 228, Reading, Berkshire RG6 6AJ, United Kingdom
    Environ Toxicol Chem 23:1241-7. 2004
    ..Our findings demonstrate different associations between AChE inhibition and toxicity when different chemicals are compared. Therefore, the value of using AChE activity as a biomarker in D. magna will be dependent on the chemical tested...
  25. ncbi Ammonium sulfate gradient loading of brucine into liposomes: effect of phospholipid composition on entrapment efficiency and physicochemical properties in vitro
    Jun Chen
    College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, PR China
    Drug Dev Ind Pharm 36:245-53. 2010
    ..We developed a novel liposome-based brucine formulation that was composed of soybean phosphatidylcholine (SPC) and hydrogenated soybean phosphatidylcholine (HSPC)...
  26. ncbi Cross neutralization of Hypnale hypnale (hump-nosed pit viper) venom by polyvalent and monovalent Malayan pit viper antivenoms in vitro and in a rodent model
    Choo Hock Tan
    Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Acta Trop 117:119-24. 2011
    ..50mgvenom/mL antivenom), another common cause of snake bites in Sri Lanka and South India. These findings suggested that the Hemato polyvalent antivenom may be beneficial in the antivenom treatment of H. hypnale envenoming...
  27. ncbi Characterization of the D/C mosaic neurotoxin produced by Clostridium botulinum associated with bovine botulism in Japan
    Keiji Nakamura
    Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1 1 Gakuen cho, Naka ku, Sakai, Osaka 599 8531, Japan
    Vet Microbiol 140:147-54. 2010
    ..These results indicate that D/C mosaic neurotoxin is a pathogenic agent causing bovine botulism and has unique characteristics different from other type C and D neurotoxins...
  28. ncbi Threshold levels for effects of insecticides in freshwater ecosystems: a review
    Rene P A van Wijngaarden
    Alterra, Wageningen UR, P O Box 47, NL 6700 AA Wageningen, The Netherlands
    Ecotoxicology 14:355-80. 2005
    ..The consistency of response patterns found in model ecosystem studies can be useful when estimating the ecological risks of pesticides. The use of an effect classification system was also helpful in evaluating effects...
  29. ncbi An in vivo but insensate model for the evaluation of antivenoms (ED(50)) using fertile hens' eggs
    P G Sells
    Alistair Reid Venom Research Unit, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA, Liverpool, UK
    Toxicon 39:665-8. 2001
    ..Use of the egg ED(50) test would substantially reduce both the numbers of experimental animals required and also the considerable costs involved in delivering improved clinical treatment of snakebite...
  30. ncbi Insecticide resistance in the bed bug: a factor in the pest's sudden resurgence?
    Alvaro Romero
    Department of Entomology, University of Kentucky, Lexington, KY 40546, USA
    J Med Entomol 44:175-8. 2007
    ..Without the development of new tactics for bed bug management, further escalation of this public health problem should be expected...
  31. ncbi Cynomolgus macaque model for pneumonic plague
    Richard Warren
    Battelle Biomedical Research Center, 505 King Ave, Columbus, OH 43201, USA
    Microb Pathog 50:12-22. 2011
    ..pestis CO92 is similar to that of pneumonic plague in humans. Thus, the CM is an appropriate model to evaluate efficacy of a recombinant F1V vaccine candidate...
  32. pmc Neutralization of two North American coral snake venoms with United States and Mexican antivenoms
    Elda E Sanchez
    Natural Toxins Research Center, 975 W Avenue B, MSC 158, Texas A and M University Kingsville, Kingsville, TX 78363, USA
    Toxicon 51:297-303. 2008
    ..f.fulvius venom and was not effective in neutralizing three LD(50) doses of M.t.tener venom. Coralmyn is effective in the neutralization of both clinically important coral snake venoms in the US...
  33. ncbi Evaluation of novel insecticides for control of dengue vector Aedes aegypti (Diptera: Culicidae)
    Ayesa Paul
    Department of Entomology, Comstock Hall, Cornell University, Ithaca, NY 14853, USA
    J Med Entomol 43:55-60. 2006
    ..Pyriproxyfen was confirmed as a potent IGR (EC50 of 0.0017 ng/ml) for mosquitoes, although tebufenozide lacked activity. The potential for use of these materials in mosquito control is discussed...
  34. ncbi New ecotoxicological model to simulate survival of aquatic invertebrates after exposure to fluctuating and sequential pulses of pesticides
    Roman Ashauer
    Environment Department, University of York, Heslington, York YO10 5DD, United Kingdom
    Environ Sci Technol 41:1480-6. 2007
    ..The Threshold Damage Model is particularly useful because its parameters can be used to calculate recovery times, toxicokinetics are separated from toxicodynamics, and parameter values reflect the mode of action...
  35. ncbi Immune response of zebrafish (Danio rerio) against a newly isolated bacterial pathogen Aeromonas hydrophila
    I Rodriguez
    Instituto de Investigaciones Marinas, Consejo Superior de Investigaciones Cientificas CSIC, Vigo, Spain
    Fish Shellfish Immunol 25:239-49. 2008
    ..Expression levels of iNOS were upregulated by ECPs. Mortality rate (LD(50)) and histopathology were also determined...
  36. pmc Biocompatibility of Fe3O4/DNR magnetic nanoparticles in the treatment of hematologic malignancies
    Weiwei Wu
    Department of Hematology, The Affiliated Zhongda Hospital, Southeast University, Nanjing, People s Republic of China
    Int J Nanomedicine 5:1079-84. 2010
    ....
  37. ncbi Antidiabetic effect of Ficus bengalensis aerial roots in experimental animals
    Rakesh Kumar Singh
    Alternative Therapeutics Unit, Drug Development Division, Medicinal Research Lab, Department of Chemistry, University of Allahabad, Allahabad, 211 002, India
    J Ethnopharmacol 123:110-4. 2009
    ..Herbal preparations of Ficus bengalensis had been considered as effective, economical and safe ethnomedicines for various ailments in Indian traditional system of medicine...
  38. ncbi Critical body residues linked to octanol-water partitioning, organism composition, and LC50 QSARs: meta-analysis and model
    A Jan Hendriks
    Department of Environmental Science, Institute for Wetland and Water Research, Faculty of Science, Radboud University Nijmegen, PO Box 9010, NL 6500 GL, Nijmegen, The Netherlands
    Environ Sci Technol 39:3226-36. 2005
    ..Moreover, the concept is applied to species (e.g., plants, lean animals) and substances (e.g., specific modes of action) that were scarcely studied quantitatively so far...
  39. ncbi Distribution and toxicity of sediment-associated pesticides in agriculture-dominated water bodies of California's Central Valley
    D P Weston
    Department of Integrative Biology, University of California, 3060 Valley Life Sciences Building, Berkeley, California 94720 3140, USA
    Environ Sci Technol 38:2752-9. 2004
    ....
  40. ncbi Brazilian IgY-Bothrops antivenom: Studies on the development of a process in chicken egg yolk
    A S Araújo
    Departamento de Medicina Veterinaria Preventiva, Escola de Veterinaria, UFMG, Av Antonio Carlos 6627, P O Box 567, CEP 30123 970, Belo Horizonte, Brazil
    Toxicon 55:739-44. 2010
    ..0 mL of IgY antivenom neutralized 0.154 mg of venom...
  41. ncbi Identification and evaluation of pyrethroid insecticide mixtures in urban sediments
    Andrew J Trimble
    Fisheries and Illinois Aquaculture Center and Department of Zoology, Southern Illinois University, Carbondale, Illinois 62901 4306, USA
    Environ Toxicol Chem 28:1687-95. 2009
    ..Whereas the concentration-addition model adequately predicted toxicity for all the pyrethroid mixtures (MDRs within a factor of two), dose-response values deviated from additivity enough to warrant further investigation...
  42. pmc Role of neonicotinyl insecticides in Washington apple integrated pest management. Part I. Control of lepidopteran pests
    J F Brunner
    Department of Entomology, Tree Fruit Research and Extension Center, Washington State University, 1100 N Western Ave, Wenatchee, Washington, USA
    J Insect Sci 5:14. 2005
    ..The advantages and disadvantages of the neonicotinyl insecticides as replacements for the organophosphate insecticides and their role in a pest management system for Washington apple orchards are discussed...
  43. ncbi Use and toxicity of pyrethroid pesticides in the Central Valley, California, USA
    Erin L Amweg
    Department of Integrative Biology, University of California, Berkeley, California 94720 3140, USA
    Environ Toxicol Chem 24:966-72. 2005
    ..A reanalysis of previously reported field data using these toxicity data confirms that the compounds are exceeding concentrations acutely toxic to sensitive species in many agriculture-dominated water bodies...
  44. ncbi Bioaccumulation and elimination of avermectin B1a in the earthworms (Eisenia fetida)
    Yingjian Sun
    Department of Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, Beijing 100094, PR China
    Chemosphere 60:699-704. 2005
    ..About 80.0% and 94.8% of the accumulated AVM B1a were eliminated respectively in two groups within 1 day after they were exposed to AVM B1a-free soil, but a trace amount of AVM B1a was found for a relative long time in earthworms...
  45. ncbi Postexposure feeding depression: a new toxicity endpoint for use in laboratory studies with Daphnia magna
    Ruth A McWilliam
    Environment Group, Institute of Aquaculture, University of Stirling, Scotland, United Kingdom
    Environ Toxicol Chem 21:1198-205. 2002
    ..In combination, these endpoints offer a potentially more sensitive, ecologically relevant alternative to the use of lethality alone for in situ bioassay studies...
  46. ncbi Assessing contaminant sensitivity of endangered and threatened aquatic species: part I. Acute toxicity of five chemicals
    F J Dwyer
    United States Fish and Wildlife Service, Columbia, Missouri 65203, USA
    Arch Environ Contam Toxicol 48:143-54. 2005
    ..When direct toxicity testing cannot be performed, approaches for developing protective measures using common test species toxicity data are available...
  47. ncbi Laboratory toxicity test and post-exposure feeding inhibition using the giant freshwater prawn Macrobrachium rosenbergii
    Kriengkrai Satapornvanit
    Department of Fishery Biology, Faculty of Fisheries, Kasetsart University, Bangkhen, Chatuchak, Bangkok 10900, Thailand
    Chemosphere 74:1209-15. 2009
    ..This study demonstrated that the M. rosenbergii could also be used as a test animal to detect the effects of different chemical contaminants in aquatic environments...
  48. ncbi Antiplasmodial, anti-trypanosomal, anti-leishmanial and cytotoxicity activity of selected Tanzanian medicinal plants
    H M Malebo
    National Institute for Medical Research, P O Box 9653, Dar es Salaam, Tanzania
    Tanzan J Health Res 11:226-34. 2009
    ....
  49. ncbi Larvicidal activity of Saraca indica, Nyctanthes arbor-tristis, and Clitoria ternatea extracts against three mosquito vector species
    Nisha Mathew
    Vector Control Research Centre ICMR, Indira Nagar, Pondicherry, 605006, India
    Parasitol Res 104:1017-25. 2009
    ..In conclusion, bioassay-guided fractionation of effective extracts may result in identification of a useful molecule for the control of mosquito vectors...
  50. ncbi Statistical evaluation of the fixed concentration procedure for acute inhalation toxicity assessment
    Nigel Stallard
    Medical and Pharmaceutical Statistics Research Unit, The University of Reading, Reading, UK
    Hum Exp Toxicol 22:575-85. 2003
    ....
  51. ncbi Assessment of antidiabetic potential of Cynodon dactylon extract in streptozotocin diabetic rats
    Santosh Kumar Singh
    Alternative Therapeutics Unit, Drug Discovery and Development Division, Medicinal Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad 211002, India
    J Ethnopharmacol 114:174-9. 2007
    ..These results clearly indicate that aqueous extract of Cynodon dactylon has high antidiabetic potential along with significant hypoglycemic and hypolipidemic effects...
  52. ncbi Acute toxicity of ochratoxin-A in marine water-reared sea bass (Dicentrarchus labrax L.)
    Yasser Said El-Sayed
    Department of Veterinary Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Alexandria University, Edfina, Behera Province, Egypt
    Chemosphere 75:878-82. 2009
    ..We concluded that sea bass is a species highly sensitive to OTA making them a useful experimental model for aquatic mycotoxigenic problems...
  53. ncbi How accurate are the European Union's classifications of chemical substances
    Christina Rudén
    Philosophy Unit, Royal Institute of Technology, Teknikringen 78B, S 100 44 Stockholm, Sweden
    Toxicol Lett 144:159-72. 2003
    ..We propose that the scientific motivations of future classifications be published and that the apparent over- and underclassifications in the present system be either explained or rectified, according to what are the facts in the matter...
  54. ncbi Susceptibility of Aedes aegypti, Culex quinquefasciatus Say, and Anopheles quadrimaculatus Say to 19 pesticides with different modes of action
    Julia W Pridgeon
    Center for Medical, Agricultural, and Veterinary Entomology, USDA ARS, Gainesville, FL 32608, USA
    J Med Entomol 45:82-7. 2008
    ....
  55. ncbi Molluscicidal saponins from Sapindus mukorossi, inhibitory agents of golden apple snails, Pomacea canaliculata
    Hui Chi Huang
    Graduate Institute of Natural Products, Kaohsiung Medical University, 100, Shi Chuan first Rd, Kaohsiung, Taiwan
    J Agric Food Chem 51:4916-9. 2003
    ..The bioassay data revealed that 1-7 were molluscicidal, causing 70-100% mortality at 10 ppm against the golden apple snail...
  56. pmc Larvicidal effects of a neem (Azadirachta indica) oil formulation on the malaria vector Anopheles gambiae
    Fredros O Okumu
    University of Nairobi, School of Biological Sciences, Nairobi, Kenya
    Malar J 6:63. 2007
    ..Costs could be reduced if larvicides could be manufactured locally. The potential of natural products as larvicides against the main African malaria vector, Anopheles gambiae s.s was evaluated...
  57. ncbi ECVAM's ongoing activities in the area of acute oral toxicity
    Agnieszka Kinsner-Ovaskainen
    In Vitro Methods Unit, European Centre for the Validation of Alternative Methods ECVAM, Institute for Health and Consumer Protection IHCP, European Commission Joint Research Centre, Ispra, Italy
    Toxicol In Vitro 23:1535-40. 2009
    ....
  58. ncbi The Registry of Cytotoxicity: toxicity testing in cell cultures to predict acute toxicity (LD50) and to reduce testing in animals
    Willi Halle
    ZEBET at the BfR, Diedersdorfer Weg 1, 12277 Berlin, Germany
    Altern Lab Anim 31:89-198. 2003
    ..Comparative studies showed that these results are highly reproducible...
  59. ncbi Studies on lethal concentrations and toxicity stress of some xenobiotics on aquatic organisms
    M Abul Farah
    Gene Tox Laboratory, Division of Genetics, Department of Zoology, Aligarh Muslim University, Aligarh 202002, UP, India
    Chemosphere 55:257-65. 2004
    ..Stress signs in the form of behavioral changes are also observed. Both types of organisms are recommended as good bioindicator for the risk assessment of aquatic environment due to chemicals tested...
  60. ncbi Palytoxin toxicity after acute oral administration in mice
    S Sosa
    Department of Materials and Natural Resources, University of Trieste, Via A Valerio 6, 34127 Trieste, Italy
    Toxicol Lett 191:253-9. 2009
    ..A NOEL of 300 microg/kg can be estimated from this acute oral toxicity study...
  61. ncbi A QSAR study of acute toxicity of N-substituted fluoroacetamides to rats
    Ivan O Juranic
    Faculty of Chemistry, University of Belgrade, P O Box 151, 11001 Belgrade, Serbia and Montenegro
    Chemosphere 62:641-9. 2006
    ..Mechanism of toxic action was proposed...
  62. ncbi Local variation in susceptibility of Colorado potato beetle (Coleoptera: Chrysomelidae) to insecticide
    Ali Asghr Pourmirza
    Department of Entomology, Urmia University, Urmia, Iran
    J Econ Entomol 98:2176-80. 2005
    ..The glass jar and filter paper testing methods are simple and sensitive test techniques for measuring susceptibility of Colorado potato beetle adults and larvae to phosalone, respectively...
  63. pmc Antimicrobial and toxicological evaluation of the leaves of Baissea axillaries Hua used in the management of HIV/AIDS patients
    Tavs A Abere
    Department of Pharmacognosy, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
    BMC Complement Altern Med 6:22. 2006
    ..Determination of its antimicrobial activity and toxicological profile will provide supportive scientific evidence in favour of its continuous usage...
  64. ncbi A comparison of model performance for six quantitative structure-activity relationship packages that predict acute toxicity to fish
    Dwayne R J Moore
    The Cadmus Group, Suite 204, 411 Roosevelt Avenue, Ottawa, Ontario K2A 3X9, Canada
    Environ Toxicol Chem 22:1799-809. 2003
    ..TOPKAT also had excellent model performance for substances within its optimum prediction space. Only 37% of the substances in the testing data set, however, fell within this optimum prediction space...
  65. ncbi Pharmacokinetics, tissue distribution and anti-tumour efficacy of paclitaxel delivered by polyvinylpyrrolidone solid dispersion
    Xiangrui Liu
    Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing, China
    J Pharm Pharmacol 64:775-82. 2012
    ..The primary aim of this study was to evaluate the pharmacokinetics, tissue distribution, acute toxicity and anti-tumour efficacy of the PSD compared with Taxol...
  66. ncbi Development of a QSAR for worst case estimates of acute toxicity of chemically reactive compounds
    A P Freidig
    Business Unit Biosciences, TNO Quality of Life, Zeist, The Netherlands
    Toxicol Lett 170:214-22. 2007
    ..The scheme was tested by an external validation...
  67. ncbi Evaluation of the pyrrole insecticide chlorfenapyr against pyrethroid resistant and susceptible Anopheles funestus (Diptera: Culicidae)
    S V Oliver
    Vector Control Reference Unit, National Institute for Communicable Diseases, Sandringham, South Africa
    Trop Med Int Health 15:127-31. 2010
    ..To evaluate the pyrrole insecticide chlorfenapyr, which has a novel non-neurotoxic mode of action and is a promising alternative to conventional adulticides, against Anopheles funestus...
  68. ncbi Sequence analysis of the small RNA segment of guinea pig-passaged Pichinde virus variants
    L Zhang
    Department of Pathology and Center for Tropical Diseases, University of Texas Medical Branch, Galveston 77555 0609, USA
    Am J Trop Med Hyg 61:220-5. 1999
    ....
  69. ncbi Pathogenicity of Fusarium oxysporum against the larvae of Culex quinquefasciatus (Say) and Anopheles stephensi (Liston) in laboratory
    Soam Prakash
    Department of Zoology, Environmental and Advanced Parasitology and Vector Control Biotechnology Laboratories, Dayalbagh Educational Institute, Dayalbagh, Agra, India
    Parasitol Res 107:651-5. 2010
    ..The results of the metabolites of F. oxysporum may be considered as a new bio-control agent for vector mosquitoes if the field trial succeeds...
  70. ncbi Contribution of AhyR to virulence of Aeromonas hydrophila J-1
    Z X Bi
    College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China
    Res Vet Sci 83:150-6. 2007
    ..Some main virulent determinants could not be detected, including proteases, amylase, Dnase, hemolysin and S layer. This article confirmed the important function of AhyR in the pathogenesis of A. hydrophila J-1...
  71. ncbi Acute toxicity bioassays of mercuric chloride and malathion on air-breathing fish Channa punctatus (Bloch)
    Sanjay Pandey
    National Bureau of Fish Genetics Resources, Canal Ring Road, Telibagh, P O Dilkusha, Lucknow 226 002, India
    Ecotoxicol Environ Saf 61:114-20. 2005
    ..The results indicate that mercuric chloride is more toxic than malathion to the fish species under study. Dose- and dose-time-dependent increases in mortality rate were also observed in response to both test chemicals...
  72. ncbi General linearized biexponential model for QSAR data showing bilinear-type distribution
    Peter Buchwald
    IVAX Research, Inc, 4400 Biscayne Blvd, Miami, Florida 33137, USA
    J Pharm Sci 94:2355-79. 2005
    ....
  73. ncbi Structure-toxicity relationships study of a series of organophosphorus insecticides
    Mohamed Zahouily
    Chimie Appliquée, Laboratoire de Synthèse Organique et Traitement de l Information Chimique, Departement de Chimie, Faculte des Sciences et Techniques, B P 146, Mohammedia 20650, Maroc
    J Mol Model 8:168-72. 2002
    ..966, s = 0.200 and q2 = 0.647). The statistics for the prediction on toxicity [log LD50 (lethal dose 50, oral, rat)] in the test set of 20 organophosphorus insecticides derivatives is (r = 0.849, s = 0...
  74. ncbi Structure-toxicity relationships of nitroaromatic compounds
    Olexandr Isayev
    Computational Center for Molecular Structure and Interactions, Jackson State University, Jackson, Mississippi, USA
    Mol Divers 10:233-45. 2006
    ..The toxicity LD50 parameter for rats has been utilized for the first time for QSAR analysis of nitrobenzenes. The predictive ability of the models is determined by a cross-validation "leave-one-out" method...
  75. pmc Pattern of mutation in the genome of influenza A virus on adaptation to increased virulence in the mouse lung: identification of functional themes
    E G Brown
    Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, ON, Canada
    Proc Natl Acad Sci U S A 98:6883-8. 2001
    ..Analysis of viral adaptation by serial passage appears to provide the identification of biologically relevant mutations...
  76. ncbi Toxicological assessment of the aqueous root extract of Sanseviera liberica Gerome and Labroy (Agavaceae)
    Muibat B Amida
    Department of Pharmacology, College of Medicine of the University of Lagos, Idi Araba, P M B 12003 Lagos, Lagos, Nigeria
    J Ethnopharmacol 113:171-5. 2007
    ..Results indicate that oral doses of SL are relatively safe in rats; however, assessment of hepato-biliary function should be done during chronic use in humans...
  77. ncbi Toxic ratio as an indicator of the intrinsic toxicity in the assessment of persistent, bioaccumulative, and toxic chemicals
    Valérie Maeder
    Swiss Federal Institute of Technology, Institute for Chemical and Bioengineering, CH 8093 Zurich, Switzerland
    Environ Sci Technol 38:3659-66. 2004
    ..The toxicity of specifically toxic hydrophilic substances is given additional emphasis by high TR values. These classification changes require that the interpretation of the B and T dimensions in PBT assessments is redefined...
  78. ncbi Impact of inhalation exposure modality and particle size on the respiratory deposition of ricin in BALB/c mice
    Chad J Roy
    Division of Toxinology and Aerobiology, U S Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, USA
    Inhal Toxicol 15:619-38. 2003
    ..This result indicates a differential lethality that is contingent upon aerosol size...
  79. ncbi Biological effect of the Planktothrix sp. FP1 cyanobacterial extract
    M Prati
    Department of Structural and Functional Biology, University of Insubria, via J H Dunant 3, 21100 Varese, Italy
    Toxicon 40:267-72. 2002
    ..944g/l wet weight). The same extract inhibited the proliferation of PBMC stimulated in vitro by phytohemagglutinin (PHA), and strongly interfered with the production of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma)...
  80. ncbi Acute toxicity of gymnodimine to mice
    Rex Munday
    AgResearch, Ruakura Research Centre, Private Bag 3123, Hamilton, New Zealand
    Toxicon 44:173-8. 2004
    ....
  81. ncbi Classifying environmental pollutants: Part 3. External validation of the classification system
    H J Verhaar
    OpdenKamp, Registration and Notification, The Hague, The Netherlands
    Chemosphere 40:875-83. 2000
    ..Furthermore, some groups of compounds cannot be classified, although they should be amenable to predictions. For these compounds additional research as to class membership and associated prediction rules is proposed...
  82. ncbi Larvicidal activity of extracts of Ginkgo biloba exocarp for three different strains of Culex pipiens pallens
    Lixin Sun
    Department of Parasitology, Nanjing Medical University, Jiangsu Province Key Lab of Modern Pathogen Biology, Nanjing 210029, People s Republic of China
    J Med Entomol 43:258-61. 2006
    ..2 mg/kg and 557.9 mg/liter, respectively. These results are promising in creating new, effective, and affordable approaches to mosquito control...
  83. ncbi Toxicity of the mosquito control pesticide Scourge to adult and larval grass shrimp (Palaemonetes pugio)
    Peter Key
    National Ocean Service, Center for Coastal Environmental Health and Biomolecular Research, Charleston, SC 29412, USA
    J Environ Sci Health B 40:585-94. 2005
    ..The results also demonstrate that synergized resmethrin is more toxic to P. pugio than the nonsynergized form, and that the presence of sediment decreases the toxicity of both resmethrin and Scourge...
  84. ncbi [Toxicity assessment of the vegetable emulsifier- the aqueous extract from the common soapwort roots]
    T P Iudina
    Vopr Pitan 75:50-2. 2006
    ..Comparative analysis of results allows to expel toxic effect AEAR in the recommended dose on an organism of animals...
  85. ncbi Comparative toxicity of three ecdysone agonist insecticides against the Mediterranean flour moth
    M Hami
    Laboratoire de Biologie Animale Appliquée, Faculte des Sciences, Université d Annaba 23000 Annaba, Algerie
    Commun Agric Appl Biol Sci 70:767-73. 2005
    ..Finally, measurements of ovarian ecdysteroids' production by an enzyme immunoassay showed an increase in the hormonal amounts recorded in treated series compared to control series...
  86. ncbi Insecticidal action of Bauhinia monandra leaf lectin (BmoLL) against Anagasta kuehniella (Lepidoptera: Pyralidae), Zabrotes subfasciatus and Callosobruchus maculatus (Coleoptera: Bruchidae)
    Maria Ligia Rodrigues Macedo
    Laboratório de Purificação de Proteínas e suas Funções Biológicas, Departamento de Ciencias Naturais, CPTL, Universidade Federal do Mato Grosso do Sul UFMS, Avenida Capitão Olinto Mancini, Tres Lagoas, MS, Brazil
    Comp Biochem Physiol A Mol Integr Physiol 146:486-98. 2007
    ..maculatus larvae increased the digestion of potato starch by 25% compared with the control. The transformation of the genes coding for this lectin could be useful in the development of insect resistance in important agricultural crops...
  87. ncbi Influence of light in acute toxicity bioassays of imidacloprid and zinc pyrithione to zooplankton crustaceans
    Francisco Sanchez-Bayo
    Laboratory of Applied Entomology and Zoology, Faculty of Horticulture, Chiba University, 648 Matsudo shi, Chiba 271 8510, Japan
    Aquat Toxicol 78:262-71. 2006
    ....
  88. ncbi Aquatic ecotoxicity of a pheromonal antagonist in Daphnia magna and Desmodesmus subspicatus
    Esmeralda Rosa
    Department of Biological Organic Chemistry, IIQAB CSIC, Jordi Girona 18 26, 08034 Barcelona, Spain
    Aquat Toxicol 79:296-303. 2006
    ....
  89. ncbi Antifungal Activity of Chromolaena odorata (L.) King & Robinson(Asteraceae) of Cameroon
    A Ngono Ngane
    Laboratoire de Biochimie, Faculte des Sciences, Douala, Cameroun
    Chemotherapy 52:103-6. 2006
    ..No toxic effect was observed in mice treated per os with the extract. This study provides a scientific confirmation of the use of Chromolaena odorata in traditional medicine...
  90. ncbi Antimalaria activity of ethanolic extract of Tetrapleura tetraptera fruit
    Jude E Okokon
    Pharmacology and Toxicology Department, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria
    J Ethnopharmacol 111:537-40. 2007
    ..The fruit extract possesses significant (P < 0.05) antiplasmodial activity with may have contributed to the immune status of the Nigerians against malaria in addition to its nutritive value...
  91. ncbi Toxicity of carbaryl, diquat dibromide, and fluoranthene, individually and in mixture, to larval grass shrimp, Palaemonetes pugio
    Katy W Chung
    JHT Incorporated Contractor to National Oceanic and Atmospheric Administration National Ocean Service National Centers for Coastal Ocean Service Center for Coastal Environmental Health and Biomolecular Research, Orlando, FL 32826, USA
    J Environ Sci Health B 43:293-9. 2008
    ..02 microg/L) and diquat dibromide (1624 microg/L). In the chemical mixture tests, the binary carbaryl/diquat dibromide mixture and the ternary carbaryl/diquat dibromide/fluoranthene mixture had additive results...
  92. ncbi Comparative toxicity of nine metals to two Malaysian aquatic dipterian larvae with reference to temperature variation
    V J Vedamanikam
    University College of Science and Technology KUSTEM, Mengabang Telipot, Kuala Terengganu 21030, Malaysia
    Bull Environ Contam Toxicol 80:516-20. 2008
    ..This trend was observed in all metals for both C. plumosus and C. furens. Thus indicating temperature played an important role in determining LC(50) values of toxicants...
  93. ncbi Effects of alpha-mangostin from mangosteen pericarp extract and imidacloprid on Nilaparvata lugens (Stal.) and non-target organisms: toxicity and detoxification mechanism
    Vasakorn Bullangpoti
    Dept of Zoology, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand
    Commun Agric Appl Biol Sci 72:431-41. 2007
    ....
  94. ncbi Effects of the statin antihyperlipidemic agent simvastatin on grass shrimp, Palaemonetes pugio
    Peter B Key
    National Ocean Service, Center for Coastal Environmental Health and Biomolecular Research, 219 Ft Johnson Road, Charleston, SC 29412, USA
    Environ Toxicol 23:153-60. 2008
    ..Both lethal and sublethal effects associated with simvastatin exposure were only observed at concentrations well above those reported in the environment...
  95. ncbi Larvicidal activity of some Euphorbiaceae plant extracts against Aedes aegypti and Culex quinquefasciatus (Diptera: Culicidae)
    A Abdul Rahuman
    Unit of Bioactive Natural Products, Department of Zoology, C Abdul Hakeem College, Melvisharam 632 509, India
    Parasitol Res 102:867-73. 2008
    ..aegypti and C. quinquefasciatus. This is an ideal ecofriendly approach for the control of the dengue vector, A. aegypti, and the lymphatic filariasis vector, C. quinquefasciatus...
  96. ncbi Effects of the anti-fouling herbicide Irgarol 1051 on two life stages of the grass shrimp, Palaemonetes pugio
    Peter B Key
    National Ocean Service, Center for Coastal Environmental Health and Biomolecular Research, Charleston, SC 29405, USA
    J Environ Sci Health B 43:50-5. 2008
    ..Both lethal and sublethal effects associated with irgarol exposure were only observed at concentrations well above those reported in the environment...
  97. ncbi Genotoxicity assessment of acute exposure of chlorpyrifos to freshwater fish Channa punctatus (Bloch) using micronucleus assay and alkaline single-cell gel electrophoresis
    Daoud Ali
    National Bureau of Fish Genetic Resources, Canal Ring Road, Telibagh, P O Dilkusha, Lucknow 226 002, India
    Chemosphere 71:1823-31. 2008
    ..This study explored the combined use of micronucleus assay and comet assay for in vivo laboratory studies using fresh water fish for screening the genotoxic potential of xenobiotics...
  98. ncbi Speciation, behavior, and bioavailability of copper downstream of a mine-impacted lake
    Alan J Martin
    Lorax Environmental Services, Vancouver, British Columbia, Canada
    Environ Toxicol Chem 26:2594-603. 2007
    ..The relevance of the toxicity data to water-effect ratio testwork, and the associated development of site-specific water quality objectives, are discussed...
  99. ncbi Preliminary toxicity study of dichloromethane extract of Kielmeyera coriacea stems in mice and rats
    Simoni Obici
    Departamento de Farmácia e Farmacologia, Universidade Estadual de Maringa, Maringa, Parana, Brazil
    J Ethnopharmacol 115:131-9. 2008
    ..In conclusion, these investigations appeared to indicate the safety of acute and repeated oral administration of the DcM extract of Kielmeyera coriacea stems, which can therefore be continuously used with safety...
  100. ncbi Zooplankton chitobiase activity as an endpoint of pharmaceutical effect
    S M Richards
    Department of Biologic and Environmental Sciences, University of Tennessee Chattanooga, Chattanooga, TN 37403, USA
    Arch Environ Contam Toxicol 54:637-44. 2008
    ..Differences were also detected for the other compounds. The response of chitobiase was found to be promising as an assay to measure sublethal effects in D. magna and perhaps other zooplankton species...
  101. ncbi Examining the joint toxicity of chlorpyrifos and atrazine in the aquatic species: Lepomis macrochirus, Pimephales promelas and Chironomus tentans
    W Tyler Mehler
    Fisheries and Illinois Aquaculture Center and Department of Zoology, Southern Illinois University at Carbondale, Carbondale, IL 62901 6511, USA
    Environ Pollut 152:217-24. 2008
    ..From the data collected, the combination of atrazine and chlorpyrifos pose little additional risk than that of chlorpyrifos alone to the tested fish species...

Research Grants38

  1. Immune Reconstitution in Nonhuman Primates
    Thomas Macvittie; Fiscal Year: 2005
    ..Clearly the ability to colonize mucosal surfaces in the respiratory, intestinal, and genital tracts also require the orchestrated synthesis of fimbriae for adherence and flagella for motility. ..
  2. Selfish gene and genetic control of vector-borne diseases
    ZACH ADELMAN; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  3. Amino acid prototrophy as a positive selective marker in Francisella
    James Bina; Fiscal Year: 2008
    ..tularensis strains. [unreadable] [unreadable] [unreadable]..
  4. Forward and Reverse Genetics in Mosquitoes Using an RNA Virus
    ZACH ADELMAN; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  5. ASSAY FOR DETERMINING DRUG TOXICITY
    Chuenlei Parng; Fiscal Year: 2004
    ..abstract_text> ..
  6. Feasibility Study of Three NCEs for Rheumatoid Arthritis
    Jiajiu Shaw; Fiscal Year: 2004
    ..Ultimately, the successful drug candidate will provide a significantly improved therapy for patients suffering from Rheumatoid Arthritis. ..
  7. NOVEL USE OF ZEBRAFISH FOR APOPTOSIS ASSAY
    Chuenlei Parng; Fiscal Year: 2004
    ..Complementary visual and flow cytometry based assays will also be developed to provide comprehensive analysis of apoptosis in zebrafish. ..
  8. TNF-alpha modulator as a radioprotector in liver
    Jiajiu Shaw; Fiscal Year: 2006
    ..The ultimate goal is to develop a radioprotective drug to be used in conjunction with radio therapy. [unreadable] [unreadable] [unreadable]..
  9. Deciphering toxin neutralization by oligoclonal antibody
    James Marks; Fiscal Year: 2003
    ..In addition, this approach would be applicable to four of the other Class A agents (anthrax, smallpox, plague, and hemorrhagic fever viruses). ..
  10. NEURAL MECHANISMS OF SOUND LOCALIZATION
    Zhongmin Lu; Fiscal Year: 2007
    ..Single-cell recording will determine if there are neurons in the medulla and/or midbrain of the goldfish that encode specific timing differences between particle motion and pressure inputs. ..
  11. Adaptive immunity of P. aeruginosa in cystic fibrosis
    GREGORY PRIEBE; Fiscal Year: 2006
    ..Knowledge gained from these studies will elucidate new strategies for the prevention and treatment of P. aeruginosa infections in the setting of CF. [unreadable] [unreadable] [unreadable]..
  12. PERMEATION OF IRRITANT MIXTURES THRU PROTECTIVE MATERIAL
    SHANE QUE HEE; Fiscal Year: 2002
    ..The relationship of the fundamental independent variables to the kinetic parameters of permeation and to the Corrositex rating as the index of irritation will be determined and compared. ..
  13. Inductively Coupled Plasma- Mass Spectrometer
    SHANE QUE HEE; Fiscal Year: 2003
    ..A team of researchers has been assembled whose research needs for elemental analyses are in the broad areas of environmental health, nutrition, biomedical and behavioral research. ..
  14. Can acclimation to toxins lead to sustained resistance?
    ALAN KOLOK; Fiscal Year: 2002
    ..We hypothesize that the results of the larval survivability tests will depend upon the exposure history (acclimation) of the parents, not the relative genetic susceptibility of the parents ..
  15. MODELING AND DOSIMETRY FOR RADIOLABELED ANTIBODY THERAPY
    George Sgouros; Fiscal Year: 2002
    ....
  16. Development of UTL-5b for Rheumatoid Arthritis: Mechanism of Action
    Jiajiu Shaw; Fiscal Year: 2007
    ..This phase 1 study will focus on a comprehensive collagen-induced arthritis animal study. [unreadable] [unreadable] [unreadable]..
  17. Development of Genetic Tools for Clostridium botulinum
    Eric Johnson; Fiscal Year: 2005
    ..abstract_text> ..
  18. Use of host derived lipoate by Listeria monocytogenes
    MARY O RIORDAN; Fiscal Year: 2009
    ..In addition, the characterization of Lm mutants that are defective in intracellular growth will provide new candidates for live vaccine development and may identify new targets for anti-microbial therapeutics. ..
  19. EFFECTS OF NONUNIFORM DISTRIBUTIONS OF RADIOACTIVITY
    Roger Howell; Fiscal Year: 2009
    ..Finally, to initiate transition of our multicellular dosimetry approach to in vivo, we will carry out bystander studies in mouse testis. ..
  20. Assessment of the Chemical Biology of HNO via New Donors
    Katrina M Miranda; Fiscal Year: 2010
    ..Additionally, new biological targets, such as zinc fingers and non-heme iron centers, are likely to be revealed, which may suggest other therapeutic interventions. ..
  21. 2008 Spirochetes Gordon Research Conference
    David Haake; Fiscal Year: 2008
    ..Funding from the National Institutes of Health is requested to partially offset the travel and registration expenses of the participating graduate students, fellows, and junior faculty members. ..
  22. OmpR and acid regulation of Escherichia coli fim genes
    WILLIAM SCHWAN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  23. Targeted Alpha-Particle Emitter Therapy of Metastases
    George Sgouros; Fiscal Year: 2009
    ..The work described in this application is intended to develop and evaluate such an approach. ..
  24. Development of botulinum neurotoxin immunotherapy
    James Marks; Fiscal Year: 2007
    ..Such information will be invaluable for vaccine development as well as diagnostic testing and microbial forensics. ..
  25. Developing antibodies to diagnose cerebral vasospasm
    Joseph Clark; Fiscal Year: 2003
    ..These data will provide proof of concept that antibodies against BOXes can be used to diagnose and predict vasospasm in SAH patients. ..
  26. Nicotinic Receptors in Septally Innervated Hippocampus
    EDSON ALBUQUERQUE; Fiscal Year: 2004
    ....
  27. Synthesis/Biological evaluation of Anti-HIV Nucleosides
    David Chu; Fiscal Year: 2005
    ..This is the first such studies demonstrating the potential of this molecular modeling approach. ..
  28. Zebrafish Screen for Neuroprotective Anti-oxidants
    Chuenlei Parng; Fiscal Year: 2005
    ..Assessment of drug effects in a convenient vertebrate model, prior to evaluation in a complex system, such as mouse, can potentially streamline the drug development process and dramatically reduce costs. ..
  29. Digoxin Chiral Isolates as Improved Pharmaceuticals
    John Somberg; Fiscal Year: 2005
    ..The advantage would be a treatment for AF that did not cause cardiac augmentation and vasoconstriction or a treatment for CHF that does not cause heart rate slowing or conduction disturbances. ..
  30. Biochemical Mechanisms of Cerebral Vasospasm
    Joseph Clark; Fiscal Year: 2005
    ....
  31. Cellular immunity to P. aeruginosa candidate vaccines
    GREGORY PRIEBE; Fiscal Year: 2005
    ..As a specialist in pediatric critical care and infectious diseases, his long-term goal is to develop effective immune-based interventions to prevent or ameliorate the consequences of P. aeruginosa infections. ..
  32. Synthetic lethality based assay for HTS drug discovery
    Dan Canaani; Fiscal Year: 2006
    ..Moreover, it should enable the implementation of the multigene shRNA expression libraries to this system, leading to the identification of gene targets synthetic lethal with ERa-deficiency in breast carcinomas. ..
  33. Proline uptake in staphylococcus aureus pathogenesis
    WILLIAM SCHWAN; Fiscal Year: 2002
    ..The results of this study will help us understand the role of proline transport in S. aureus infections. ..
  34. Cardiotoxicity Drug Screening Using Zebrafish
    Chuenlei Parng; Fiscal Year: 2004
    ..Zebrafish drug screens can serve as an intermediate step between cell-based and mammalian testing, streamlining the drug development timeline. ..
  35. Host Factors in Susceptibility to Chlamydial Disease
    KYLE RAMSEY; Fiscal Year: 2006
    ....
  36. Synthetic Lethal Screens in an Ovarian Cancer Model
    Dan Canaani; Fiscal Year: 2003
    ..I successful, it would allow the search of new drugs for ovarian malignancy, aimed at noel target/s whose specificity is insured by its/their synthetic lethality with a mutated tumor suppressor gene of interest. ..