chronic toxicity tests

Summary

Summary: Experiments designed to determine the potential toxic effects of a long-term exposure to a chemical or chemicals.

Top Publications

  1. ncbi A two-generation reproductive toxicity study of benzophenone in rats
    Nobuhito Hoshino
    Toxicology Division I, Kashima Laboratory, Mitsubishi Chemical Safety Institute Ltd, 14 Sunayama, Kamisu shi, Ibaraki 314 0255, Japan
    J Toxicol Sci 30:5-20. 2005
  2. ncbi Toxicological assessment of the aqueous root extract of Sanseviera liberica Gerome and Labroy (Agavaceae)
    Muibat B Amida
    Department of Pharmacology, College of Medicine of the University of Lagos, Idi Araba, P M B 12003 Lagos, Lagos, Nigeria
    J Ethnopharmacol 113:171-5. 2007
  3. ncbi Chronic toxicity and carcinogenicity of 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin displays a distinct dose/time toxicity threshold (c x t = k) and a life-prolonging subthreshold effect
    Karl K Rozman
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Food Chem Toxicol 43:729-40. 2005
  4. ncbi Assessment of reproductive toxicity in male rats following acute and sub-chronic exposures to diphenyl diselenide and diphenyl ditelluride
    Eluza Curte Stangherlin
    Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, SM, RS, CEP 97105 900 Santa Maria, Brazil
    Food Chem Toxicol 44:662-9. 2006
  5. ncbi Acute, subchronic and chronic toxicity studies of a synthetic antioxidant, 2,2'-isobutylidenebis(4,6-dimethylphenol) in rats
    Atsuya Takagi
    Division of Cellular and Molecular Toxicology, National Institute of Health Sciences, Tokyo, Japan
    J Toxicol Sci 30:275-85. 2005
  6. ncbi A two-generation reproductive toxicity study of 4-nitrotoluene in rats
    Sunao Aso
    Chemicals Evaluation and Research Institute, Ishii machi, Hita, Oita 877 0061, Japan
    J Toxicol Sci 30:117-134. 2005
  7. ncbi A two-generation reproductive toxicity study of butyl benzyl phthalate in rats
    Sunao Aso
    Chemicals Evaluation and Research Institute, Ishii machi, Hita, Oita 877 0061, Japan
    J Toxicol Sci 30:39-58. 2005
  8. ncbi Allometric principles for interspecies extrapolation in toxicological risk assessment--empirical investigations
    K Schneider
    Forschungs und Beratungsinstitut Gefahrstoffe FoBiG GmbH, Werderring 16, Freiburg D 79098, Germany
    Regul Toxicol Pharmacol 39:334-47. 2004
  9. ncbi The safety of ethyl oleate is supported by a 91-day feeding study in rats
    Robert C Bookstaff
    The Procter and Gamble Company, Health Sciences Institute, Cincinnati, OH 45241, USA
    Regul Toxicol Pharmacol 39:202-13. 2004
  10. ncbi Acute and chronic toxicological studies of Dimorphandra mollis in experimental animals
    C A O Feres
    Laboratorio de Toxicologia Experimental, Departamento de Analises Clinicas e Toxicologicas, Belo Horizonte, Minas Gerais, Brazil
    J Ethnopharmacol 108:450-6. 2006

Research Grants

  1. Synaptosomal Protein Changes After EtOH Self-Administration
    Frank Witzmann; Fiscal Year: 2006
  2. CHEMICAL DISPOSITION IN MAMMALS SRI INTERNATIONAL
    Carol Green; Fiscal Year: 2000
  3. Pharmacogenomics/natural products + antifungal activity
    John Cleary; Fiscal Year: 2004
  4. Drug Abuse Vulnerability: Role of Development and Gender
    Lisa M Schrott; Fiscal Year: 2010
  5. METHANOL EXPOSURE EFFECTS ON PRIMATE DEVELOPMENT
    THOMAS BURBACHER; Fiscal Year: 2001
  6. MECHANISMS OF IMMUNOSUPPRESSION BY ONE DOSE OF ETHANOL
    Stephen Pruett; Fiscal Year: 2007
  7. Mechanisms of Immunotoxcity of Chemical Stressors
    Stephen Pruett; Fiscal Year: 2005
  8. TOXICOLOGY FOR TEACHERS
    Ann de Peyster; Fiscal Year: 2003
  9. DEVELOPMENTAL EFFECTS OF METHYLMERCURY
    THOMAS BURBACHER; Fiscal Year: 2002
  10. Mechanisms of methyl dithiocarbamate immunotoxicity
    Stephen B Pruett; Fiscal Year: 2010

Detail Information

Publications219 found, 100 shown here

  1. ncbi A two-generation reproductive toxicity study of benzophenone in rats
    Nobuhito Hoshino
    Toxicology Division I, Kashima Laboratory, Mitsubishi Chemical Safety Institute Ltd, 14 Sunayama, Kamisu shi, Ibaraki 314 0255, Japan
    J Toxicol Sci 30:5-20. 2005
    ..Concerning the effects on the endocrine system and the reproductive toxicity in the parental animals, the NOEL is 2000 ppm. In terms of the effects on the offspring, the NOEL is considered to be 450 ppm...
  2. ncbi Toxicological assessment of the aqueous root extract of Sanseviera liberica Gerome and Labroy (Agavaceae)
    Muibat B Amida
    Department of Pharmacology, College of Medicine of the University of Lagos, Idi Araba, P M B 12003 Lagos, Lagos, Nigeria
    J Ethnopharmacol 113:171-5. 2007
    ..Results indicate that oral doses of SL are relatively safe in rats; however, assessment of hepato-biliary function should be done during chronic use in humans...
  3. ncbi Chronic toxicity and carcinogenicity of 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin displays a distinct dose/time toxicity threshold (c x t = k) and a life-prolonging subthreshold effect
    Karl K Rozman
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Food Chem Toxicol 43:729-40. 2005
    ..There was no correlation in the dose-dependence of non-malignant hepatic lesions and liver cancer...
  4. ncbi Assessment of reproductive toxicity in male rats following acute and sub-chronic exposures to diphenyl diselenide and diphenyl ditelluride
    Eluza Curte Stangherlin
    Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, SM, RS, CEP 97105 900 Santa Maria, Brazil
    Food Chem Toxicol 44:662-9. 2006
    ..The results suggest the absence of the male reproductive toxicity induced by (PhSe)2 and (PhTe)2 administered intraperitonealy (acute) or subcutaneously (sub-chronical) to adult rats Wistar...
  5. ncbi Acute, subchronic and chronic toxicity studies of a synthetic antioxidant, 2,2'-isobutylidenebis(4,6-dimethylphenol) in rats
    Atsuya Takagi
    Division of Cellular and Molecular Toxicology, National Institute of Health Sciences, Tokyo, Japan
    J Toxicol Sci 30:275-85. 2005
    ..84 mg/kg BW/day) on the basis of induction of thickening of basement membrane in renal tubules at 100 ppm...
  6. ncbi A two-generation reproductive toxicity study of 4-nitrotoluene in rats
    Sunao Aso
    Chemicals Evaluation and Research Institute, Ishii machi, Hita, Oita 877 0061, Japan
    J Toxicol Sci 30:117-134. 2005
    ....
  7. ncbi A two-generation reproductive toxicity study of butyl benzyl phthalate in rats
    Sunao Aso
    Chemicals Evaluation and Research Institute, Ishii machi, Hita, Oita 877 0061, Japan
    J Toxicol Sci 30:39-58. 2005
    ..The NOEL and NOAEL for the growth and development of offspring were concluded to be less than 100 mg/kg/day...
  8. ncbi Allometric principles for interspecies extrapolation in toxicological risk assessment--empirical investigations
    K Schneider
    Forschungs und Beratungsinstitut Gefahrstoffe FoBiG GmbH, Werderring 16, Freiburg D 79098, Germany
    Regul Toxicol Pharmacol 39:334-47. 2004
    ..Moreover, the evaluated data make it possible to describe uncertainty associated with the process of interspecies extrapolation by allometric rules...
  9. ncbi The safety of ethyl oleate is supported by a 91-day feeding study in rats
    Robert C Bookstaff
    The Procter and Gamble Company, Health Sciences Institute, Cincinnati, OH 45241, USA
    Regul Toxicol Pharmacol 39:202-13. 2004
    ..The No Observable Adverse Effect Level was determined to be 10% EO when administered daily in the diet for 91-days (approximately 6g EO/kg bw/day)...
  10. ncbi Acute and chronic toxicological studies of Dimorphandra mollis in experimental animals
    C A O Feres
    Laboratorio de Toxicologia Experimental, Departamento de Analises Clinicas e Toxicologicas, Belo Horizonte, Minas Gerais, Brazil
    J Ethnopharmacol 108:450-6. 2006
    ..In conclusion, the study suggest that the extract is safe in a 1000 mg/kg dose, whereas for 2000 mg/kg dose further studies are needed. In long-term use, caution is required...
  11. ncbi Acute and subchronic oral toxicity studies in rats of a hydrolyzed chicken sternal cartilage preparation
    A G Schauss
    AIBMR Life Sciences, Inc, Natural and Medical Products Research, 4117 S Meridian, Puyallup, WA 98373, USA
    Food Chem Toxicol 45:315-21. 2007
    ....
  12. ncbi Age and exposure duration as a factor influencing Cu and Zn toxicity toward Daphnia magna
    B T A Muyssen
    Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, J Plateaustraat 22, B 9000 Gent, Belgium
    Ecotoxicol Environ Saf 68:436-42. 2007
    ..As differences are observed between the two metals extrapolations of these conclusions to other toxicants and other aquatic species cannot be made without further investigation...
  13. ncbi Acute and chronic toxicity of the aqueous extract of Artemisia afra in rodents
    J T Mukinda
    Discipline of Pharmacology, School of Pharmacy and South African Herbal Science and Medicine Institute, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa
    J Ethnopharmacol 112:138-44. 2007
    ..Collectively, the results indicate that Artemisia afra-extract is non-toxic when given acutely, has low chronic toxicity potential and, in high doses, may have a hepatoprotective effect...
  14. ncbi 17alpha-methyltestosterone: 28-day oral toxicity study in the rat based on the "Enhanced OECD Test Guideline 407" to detect endocrine effects
    Sheila Wason
    Bayer CropScience, Centre de Recherche de Sophia Antipolis, BP153, F 06903 Sophia Antipolis, France
    Toxicology 192:119-37. 2003
    ..Beyond the scope of this validation exercise, an increase in apoptosis in specific germ cell types was detected using the TUNEL assay in male rats treated at 200 and 40 mg/kg...
  15. ncbi Thirteen-week oral toxicity study of L-glutamine in rats
    Shoji Tsubuku
    Health Services Development Department, Ajinomoto Co Inc, 1 15 1 Chuo ku, 104 8315 Tokyo, Japan
    Int J Toxicol 23:107-12. 2004
    ..No effects of administration were observed in the 1.25% group. The no-observed-adverse-effect level (NOAEL) for Gln was estimated at 1.25% for both genders (males 0.83 +/- 0.01 g/kg/day; females, 0.96 +/- 0.06 g/kg/day)...
  16. ncbi Subchronic (13-week) oral toxicity study, preceded by an in utero exposure phase, with arachidonate-enriched triglyceride oil (SUNTGA40S) in rats
    B A R Lina
    TNO Quality of Life, Toxicology and Applied Pharmacology, Zeist, The Netherlands
    Food Chem Toxicol 44:326-35. 2006
    ..Except during lactation when the intake in dams doubled, 5% Suntga40S in the diet was equivalent to an overall intake of approximately 3g/kg body weight/day in F(0) and F(1) animals...
  17. ncbi Results of chronic dietary toxicity studies of high viscosity (P70H and P100H) white mineral oils in Fischer 344 rats
    Gary W Trimmer
    ExxonMobil Biomedical Sciences, Inc, Annandale, New Jersey, USA
    Toxicol Pathol 32:439-47. 2004
    ..Thus, under the conditions of these studies, the No Observable Adverse Effect Level (NOAEL) for these studies was considered to be 1,200 mg/kg/day...
  18. ncbi Absence of toxic effects in F344/N rats and B6C3F1 mice following subchronic administration of chromium picolinate monohydrate
    M C Rhodes
    National Institute of Environmental Health Sciences, Mail Drop EC 34, 79 TW Alexander Drive, Research Triangle Park, NC 27709, United States
    Food Chem Toxicol 43:21-9. 2005
    ..No compound-related changes in hematology and clinical chemistry parameters were observed. There were no histopathological lesions attributed to CPM in rats or mice...
  19. ncbi Subchronic toxicity of a fluoroalkylethanol mixture in rats
    Gregory S Ladics
    DuPont Company Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Drug Chem Toxicol 28:135-58. 2005
    ..Both plasma and urine fluoride levels were elevated in a dose-dependent manner. Under the conditions of the study, the no-observed adverse effect level for this mixture was 25 mg kg(-1) day(-1) for subchronic toxicity...
  20. ncbi Aquatic toxicity of nitrogen mustard to Ceriodaphina dubia, Daphnia magna, and Pimephales promelas
    Cheng Hang Lan
    Department of Industrial Safety and Hygiene, Chung Hwa College of Medical Technology, 89 Wen hwai 1st St Jen te hsiang, Tainan, Hsien, Taiwan
    Ecotoxicol Environ Saf 61:273-9. 2005
    ..81 mug/L HN2. These adverse effects on aquatic organisms caused by lower-level concentrations of HN2 indicate that a possible aquatic ecosystem disaster could occur either after a chemical spill or during chemical warfare...
  21. ncbi Acute and chronic toxicity of five selective serotonin reuptake inhibitors in Ceriodaphnia dubia
    Theodore B Henry
    Department of Environmental Health Science, University of Georgia, Athens, Georgia 30602, USA
    Environ Toxicol Chem 23:2229-33. 2004
    ..045 mg/L and the NOEC was 0.009 mg/L. Results indicate that SSRIs can impact survival and reproduction of C. dubia; however, only at concentrations that are considerably higher than those expected in the environment...
  22. ncbi Toxicity of the crude oil water-soluble fraction and kaolin-adsorbed crude oil on Daphnia magna (Crustacea: Anomopoda)
    F Martínez-Jerónimo
    Laboratorio de Hidrobiología Experimental, Escuela Nacional de Ciencias Biologicas, Instituto Politecnico Nacional, Carpio esq Plan de Ayala s n, Mexico
    Arch Environ Contam Toxicol 48:444-9. 2005
    ..magna reproduction and survival when subjected to chronic exposure...
  23. ncbi Life-history traits of standard and autochthonous cladocerans: II. Acute and chronic effects of acetylsalicylic acid metabolites
    Catarina R Marques
    Universidade de Aveiro, Departamento de Biologia, 3810 193 Aveiro, Portugal
    Environ Toxicol 19:527-40. 2004
    ....
  24. ncbi Dietary toxicity of calcium beta-hydroxy-beta-methyl butyrate (CaHMB)
    J H Baxter
    Ross Products Division, Department 104060 RP43, Abbott Laboratories, Columbus, OH 43215 1724, USA
    Food Chem Toxicol 43:1731-41. 2005
    ..Based on the results of this study, the no-observed-adverse-effect level (NOAEL) was considered to be 5% of CaHMB mixed with diet (3.49 g/kg BW for males and 4.16 g/kg BW for females)...
  25. ncbi Chronic toxicity and carcinogenicity of dietary administered ammonium sulfate in F344 rats
    Y Ota
    Division of Pathology, National Institute of Health Sciences, Setagaya Ku, Tokyo, Japan
    Food Chem Toxicol 44:17-27. 2006
    ..6% diet, which is equivalent to 256 and 284 mg/kg b.w./day in males and females, respectively, and the compound is non-carcinogenic under the conditions of the study...
  26. ncbi Oral acute and subchronic toxicity of D-004, a lipid extract from Roystonea regia fruits, in rats
    R Gamez
    Center for Natural Products, National Center for Scientific Research, Havana City, Cuba
    Drugs Exp Clin Res 31:101-8. 2005
    ..Thus, this dose can be considered as a nonobservable-effect dose in rats...
  27. ncbi A preliminary assessment of the acute and subchronic toxicity profile of phase2: an alpha-amylase inhibitor
    Kuzhuvelil B Harikumar
    Amala Cancer Research Centre, Amala Nagar, Department of Animal Production and Aquatic Environment, Thrissur, India
    Int J Toxicol 24:95-102. 2005
    ..0 g/kg body weight). These data indicate that acute and subchronic administration of Phase2 did not produce any toxicity to rats as evident from weight change, mortality, and limited biochemical and histopathological analyses...
  28. ncbi A two-generation reproductive toxicity study of dicyclohexyl phthalate in rats
    Nobuhito Hoshino
    Toxicology Division I, Kashima Laboratory, Mitsubishi Chemical Safety Institute Ltd, 14 Sunayama, Kamisu shi, Ibaraki 314 0255, Japan
    J Toxicol Sci 30:79-96. 2005
    ..With regard to the reproductive toxicological effects on the parental animals, the NOEL is 240 ppm for males and 1200 ppm for females. For offspring, the NOEL values are concluded to be 240 ppm for males and 1200 ppm for females...
  29. ncbi A microplate freshwater copepod bioassay for evaluating acute and chronic effects of chemicals
    Rebecca J Brown
    AstraZeneca Global Safety, Health and Environment, Brixham Environmental Laboratory, Freshwater Quarry, Brixham, Devon TQ5 8BA, United Kingdom
    Environ Toxicol Chem 24:1528-31. 2005
    ..It is proposed that B. zschokkei is an ecologically relevant test species for evaluating the potential effects of contaminants on freshwater invertebrates and for giving insight into the mode of action of a test chemical...
  30. ncbi Toxicological assessment of a particulate yeast (1,3/1,6)-beta-D-glucan in rats
    K Babícek
    BIOPHARM, Research Institute of Biopharmacy and Veterinary Drugs, 254 49 Jilove, Czech Republic
    Food Chem Toxicol 45:1719-30. 2007
    ..3, or 100mg/kg body weight/day of WGP 3-6 in Fisher-344 rats, and therefore, a no observed adverse effect level (NOAEL) of 100 mg/kg body weight/day, the highest dose tested, was determined...
  31. ncbi Evaluation of the toxicity of polyvinylacetate phthalate in experimental animals
    D R Schoneker
    Colorcon, 415 Moyer Blvd, West Point, PA 19486, USA
    Food Chem Toxicol 41:405-13. 2003
    ....
  32. ncbi Toxicity and carcinogenicity studies of chlorpromazine hydrochloride and p-cresidine in the p53 heterozygous mouse model
    Janet M Petruska
    Drug Safety and Metabolism, Schering Plough Research Institute, Lafayette, New Jersey 07848, USA
    Toxicol Pathol 30:696-704. 2002
    ..This study demonstrated that chlorpromazine hydrochloride, at the doses tolerated, was not carcinogenic in the p53 heterozygous mouse assay...
  33. ncbi Acute and chronic effects of ibuprofen in the mollusc Planorbis carinatus (Gastropoda: Planorbidae)
    Nadine Pounds
    AstraZeneca Global Safety, Health and Environment, Brixham Environmental Laboratory, Devon TQ5 8BA, UK
    Ecotoxicol Environ Saf 70:47-52. 2008
    ..43 and 1.02 mg/L, respectively. We found P. carinatus to be amenable to laboratory culture and this preliminary study suggests that this species may have further potential as a useful molluscan model in ecotoxicology...
  34. ncbi An oral two-generation reproductive toxicity study of S-111-S-WB in rats
    Donald G Stump
    WIL Research Laboratories, LLC, 1407 George Road, Ashland, OH 44805, USA
    Reprod Toxicol 25:7-20. 2008
    ..025mg/(kgday) was considered to be the NOAEL for neonatal toxicity based on higher liver weights in the F(1) and F(2) pups at 0.125mg/(kgday) and higher...
  35. ncbi Dietary oral exposure to l,3,5-trinitro-1,3,5-triazine in the northern bobwhite (Colinus virginianus)
    Obert M Gogal
    Virginia Maryland Regional College of Veterinary Medicine, Blacksburg, Virginia 24061, USA
    Environ Toxicol Chem 22:381-7. 2003
    ..These collective data suggest that quail may respond differently to oral RDX exposure compared with mammals...
  36. ncbi Subchronic oral toxicity study of mixed tocopheryl phosphates in rats
    R Gianello
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Int J Toxicol 26:475-90. 2007
    ..The 1% diet (equivalent to 587 and 643 mg mixed tocopheryl phosphates/kg body weight/day for male and female rats, respectively) was considered the no observed adverse effect level...
  37. ncbi Acute and chronic effects of perfluorobutane sulfonate (PFBS) on the mallard and northern bobwhite quail
    J L Newsted
    ENTRIX, Inc, 4295 Okemos Road, Suite 101, Okemos, MI 48864, USA
    Arch Environ Contam Toxicol 54:535-45. 2008
    ..Based on the results from the quail reproduction study, the dietary NOAEC was 900 mg PFBS/kg, ww feed (equivalent to an ADI of 87.8 mg PFBS/kg bw/d)...
  38. ncbi Acute and chronic toxicity of imidacloprid to the aquatic invertebrates Chironomus tentans and Hyalella azteca under constant- and pulse-exposure conditions
    Sarah J Stoughton
    Toxicology Centre, University of Saskatchewan, 44 Campus Drive, S7N 5B3, Saskatoon, SK, Canada
    Arch Environ Contam Toxicol 54:662-73. 2008
    ....
  39. ncbi The toxicity of behenyl alcohol. I. Genotoxicity and subchronic toxicity in rats and dogs
    Guadalupe Iglesias
    Cantox Health Sciences International, Inc 2233 Argentia Road, Suite 308, Mississauga, Ontario, L5N 2X7, Canada
    Regul Toxicol Pharmacol 36:69-79. 2002
    ..The no-observed-adverse-effect-level (NOAEL) for behenyl alcohol was 1000 mg/kg body weight/day for rats, and 2000 mg/kg body weight/day for dogs, the highest doses used in these studies...
  40. ncbi 90-day oral gavage toxicity study of 8-2 fluorotelomer alcohol in rats
    Gregory S Ladics
    TRP Toxicology Program, DuPont Haskell Laboratory, Newark, Delaware, USA
    Drug Chem Toxicol 31:189-216. 2008
    ..The no-observed-adverse-effect level was 5 mg/kg...
  41. ncbi Comparative aquatic toxicity evaluation of 2-(thiocyanomethylthio)benzothiazole and selected degradation products using Ceriodaphnia dubia
    S T Nawrocki
    Department of Cancer Biology, University of Texas Houston, M D Anderson Cancer Center, Houston, Texas 77001, USA
    Arch Environ Contam Toxicol 48:344-50. 2005
    ..Toxicity data on these benzothiazole degradation products is important because of concerns regarding their release, degradation, persistence, and non-target organism effects in aquatic ecosystems...
  42. ncbi Toxicity profile of lisdexamfetamine dimesylate in three independent rat toxicology studies
    Suma Krishnan
    Shire Development Inc, 725 Chesterbrook Boulevard, Wayne, PA 19087, USA
    Basic Clin Pharmacol Toxicol 101:231-40. 2007
    ....
  43. ncbi Evaluation of short-term and subchronic toxicity of magnolia bark extract in rats
    Zhaoping Liu
    Department of Toxicological Safety Assessment, National Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing, China
    Regul Toxicol Pharmacol 49:160-71. 2007
    ..These results support the safety of MBE for oral consumption...
  44. ncbi The subchronic oral toxicity of ethane, 1,2-bis(pentabromophenyl) (Saytex 8010) in rats
    M L Hardy
    Albemarle Corporation, Baton Rouge, Louisiana 70801, USA
    Int J Toxicol 21:165-70. 2002
    ..EBP's lack of toxicity is likely related to poor bioavailability due to its high molecular weight and low solubility...
  45. ncbi A 52-week repeated dose toxicity study of ultraviolet absorber 2-(2'-hydroxy-3',5'-di-tert-butylphenyl)benzotriazole in rats
    Mutsuko Hirata-Koizumi
    Biological Safety Research Center, National Institute of Health Sciences, Tokyo, Japan
    Drug Chem Toxicol 31:81-96. 2008
    ..5 mg/kg in males. Based on these findings, the no observed adverse effect level was concluded to be 0.1 mg/kg/day in male rats and 2.5 mg/kg/day in female rats...
  46. ncbi Dosimetry considerations in the enhanced sensitivity of male Wistar rats to chronic ethylene glycol-induced nephrotoxicity
    R A Corley
    Biological Monitoring and Modeling, Battelle Pacific Northwest Division, 902 Battelle Boulevard, Richland, WA 99352, USA
    Toxicol Appl Pharmacol 228:165-78. 2008
    ..The NOAEL of 150 mg/kg/day is the same as that reported after 16-week exposure and appears to be a threshold dose below which no renal toxicity occurs, regardless of exposure duration...
  47. ncbi An assessment of the potential toxicity of runoff from an urban roadscape during rain events
    Sylvia Waara
    Department of Public Technology, Malardalen University, Box 883, 721 23 Västerås, Sweden
    Environ Sci Pollut Res Int 15:205-10. 2008
    ..The results are to be used for developing a monitoring program, including biological methods...
  48. ncbi Sensitized photooxygenation of the fungicide furalaxyl
    Maria Rosaria Iesce
    Dipartimento di Chimica Organica e Biochimica, Universita degli Studi di Napoli Federico II, Complesso Universitario Monte Sant Angelo, Via Cinthia, I 80126 Napoli, Italy
    Environ Sci Pollut Res Int 11:222-6. 2004
    ..Previous reports on the direct photolysis of the pesticide demonstrated a very slow degradation and the only identified photoproducts were N-2,6-xylyl-D,L-alaninare and 2,6-dimethylaniline...
  49. ncbi Water quality and macroinvertebrate community response following pesticide applications in a banana plantation, Limon, Costa Rica
    Luisa Eugenia Castillo
    Central American Institute for Studies on Toxic Substances IRET, Universidad Nacional, Heredia, Costa Rica
    Sci Total Environ 367:418-32. 2006
    ..assessments of pesticide use in banana plantations are currently limited by the lack of local short-term chronic toxicity tests and tests using sensitive native species...
  50. ncbi Population growth of Brachionus macracanthus (Rotifera) in relation to cadmium toxicity: influence of algal (Chlorella vulgaris) density
    S Nandini
    UIICSE, Division of Research and Postgraduate Studies, National Autonomous University of Mexico, Campus Iztacala, Los Reyes, Tlalnepantla, State of Mexico, Mexico
    J Environ Sci Health A Tox Hazard Subst Environ Eng 42:1467-72. 2007
    ..b>Chronic toxicity tests were conducted under 4 different concentrations (0.000625-0...
  51. ncbi Endocrine disruption and consequences of chronic exposure to ibuprofen in Japanese medaka (Oryzias latipes) and freshwater cladocerans Daphnia magna and Moina macrocopa
    Sunyoung Han
    School of Public Health, Seoul National University, 28 Yunkeon, Chongro, Seoul 110 799, Republic of Korea
    Aquat Toxicol 98:256-64. 2010
    ..We also conducted chronic toxicity tests using freshwater fish, Oryzias latipes, and two freshwater cladocerans, Daphnia magna and Moina macrocopa, ..
  52. ncbi Use of a mathematical model in the analysis of survival curves of Daphnia magna exposed to toxicants
    Alberto Santojanni
    Istituto di Ricerche sulla Pesca Marittima IRPEM, Consiglio Nazionale delle Ricerche CNR, Largo Fiera della Pesca, Ancona I 60125, Italy
    Water Res 37:2357-64. 2003
    b>Chronic toxicity tests carried out on species of the genus Daphnia (Crustacea: Cladocera) are bioassays commonly used in ecotoxicology. Mortality in the cohorts exposed to toxicants can be examined by the analysis of survival curves...
  53. ncbi Chronic toxicity of copper and ammonia to juvenile freshwater mussels (Unionidae)
    Ning Wang
    Columbia Environmental Research Center, U S Geological Survey, Columbia, Missouri 65201, USA
    Environ Toxicol Chem 26:2048-56. 2007
    The objectives of the present study were to develop methods for conducting chronic toxicity tests with juvenile mussels under flow-through conditions and to determine the chronic toxicity of copper and ammonia to juvenile mussels using ..
  54. ncbi Acute and chronic toxicity of the herbicide Stam M-4 in field and laboratory exposures
    M T Moore
    Department of Biology, University of Mississippi, University, Mississippi 38677, USA
    Arch Environ Contam Toxicol 33:199-202. 1997
    ..45 mg/L) than in synthetic water (5.93 mg/L) in 7-d chronic toxicity tests. Forty-eight-hour toxicity tests indicate that ground water affords organisms some assimilative capacity ..
  55. ncbi Chronic toxicity tests with Daphnia magna for examination of river water quality
    M Sakai
    Yokohama Environmental Research Institute, Takigashira, Isogo, Japan
    J Environ Sci Health B 36:67-74. 2001
    b>Chronic toxicity tests with Daphnia magna were applied for examination of river water quality. Water was sampled from the Maioka River in Yokohama City on May 14, 20, and 27, 1999, and used for the test after solid-phase extraction...
  56. ncbi Chronic toxicity of chloride to freshwater species: effects of hardness and implications for water quality guidelines
    James R F Elphick
    Nautilus Environmental, Burnaby, British Columbia, Canada
    Environ Toxicol Chem 30:239-46. 2011
    ..Data from the present chronic toxicity tests, and other investigators, were used to propose a water quality guideline for long-term exposure to ..
  57. ncbi Ecotoxicological assessment of effluents in the Basque country (Northern Spain) by acute and chronic toxicity tests using Daphnia magna straus
    Pilar Rodriguez
    Department of Zoology and Animal Cellular Biology, Faculty of Science and Technology, University of the Basque Country, PO Box 644, E 48080, Bilbao, Spain
    Ecotoxicology 15:559-72. 2006
    Acute pass/fail, multi-concentration tests, and 3-brood chronic toxicity tests with Daphnia magna Straus (Cladocera, Crustacea) were used to characterise industrial and municipal effluents from various sources...
  58. ncbi Toxicity of mercury on in vitro development of parthenogenetic eggs of a freshwater cladoceran Daphnia carinata
    B S Khangarot
    Ecotoxicology Division, Industrial Toxicology Research Centre, Post Box No 80, M G Marg, Lucknow 226001, India
    J Hazard Mater 161:68-73. 2009
    ..developmental stages of Daphnia carinata eggs that could be used as potential endpoints for sublethal and chronic toxicity tests have been investigated and defined...
  59. ncbi Comparative study on sensitivity of higher plants and fish to heavy fuel oil
    N Kazlauskiene
    Institute of Ecology, Vilnius University, Akademijos 2, LT 08412, Vilnius, Lithuania
    Environ Toxicol 19:449-51. 2004
    ..morphological parameters) as well as the genotoxic impact (Tradescantia) of HFO was evaluated by acute and chronic toxicity tests. Fish were found to be more sensitive to the toxic effect of HFO than were higher plants...
  60. ncbi Evaluation of cyanobacteria toxicity in tropical reservoirs using crude extracts bioassay with cladocerans
    Denise Tieme Okumura
    Department of Ecology and Evolutionary Biology, Biological and Health Sciences Center, Federal University of Sao Carlos, Rodovia Washington Luis, km 235, CEP 13565 905 Sao Carlos, SP, Brazil
    Ecotoxicology 16:263-70. 2007
    ..In the chronic toxicity tests, only a native cladoceran found in Brazilian freshwaters, Ceriodaphnia silvestrii, was used...
  61. ncbi Rationale for the use of dietary control in toxicity studies--B6C3F1 mouse
    A Turturro
    Division of Biometry and Risk Assessment, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    Toxicol Pathol 24:769-75. 1996
    ..weight (BW) and BW distribution all generate concern about the reproducibility, consistency, and equity of chronic toxicity tests used in regulation...
  62. ncbi Toxicity of 17alpha-ethynylestradiol and norethindrone, constituents of an oral contraceptive pill to the swimming and reproduction of cladoceran Daphnia magna, with special reference to their synergetic effect
    Takashi Goto
    Graduate School of Bioresource Sciences, Nihon University, Kameino 1866, Fujisawa, 252 8510, Kanagawa, Japan
    Mar Pollut Bull 47:139-42. 2003
    ..41 ppm. Chronic toxicity tests were carried out for 25 days by measuring the number of offspring, moltings and sex ratios of neonates at ..
  63. ncbi Acute and chronic toxicity of glyphosate compounds to glochidia and juveniles of Lampsilis siliquoidea (Unionidae)
    Robert B Bringolf
    Department of Environmental and Molecular Toxicology, North Carolina State University, Campus Box 7633, Raleigh, North Carolina 27695 7633, USA
    Environ Toxicol Chem 26:2094-100. 2007
    ..Acute and chronic toxicity tests were performed with a newly established American Society of Testing and Materials (ASTM) standard guide ..
  64. ncbi Ecological risk assessment on a cadmium contaminated soil landfill--a preliminary evaluation based on toxicity tests on local species and site-specific information
    Chien Min Chen
    Department of Environmental Resources Management, Chia Nan University of Pharmacy and Science, 60, Section 1, Er Jen Rd Jen Der, Tainan, Taiwan, ROC
    Sci Total Environ 359:120-9. 2006
    ..Chemical dissipation in groundwater systems was simulated and short-term chronic toxicity tests on larvae of three local aquatic species were also performed to determine the no-observed adverse-effect ..
  65. ncbi Effects of nano calcium carbonate and nano calcium citrate on toxicity in ICR mice and on bone mineral density in an ovariectomized mice model
    Sherry Huang
    Center for Nano Bioengineering, Chung Yuan Christian University, Chung Li 32023, Taiwan
    Nanotechnology 20:375102. 2009
    ..The measurements obtained from DLS, FE-SEM and TEM were comparable. Acute and sub-chronic toxicity tests were performed to establish the safety of these products after oral administration...
  66. ncbi Evaluation of the sensitivity of three cladoceran species widely distributed in Mexico to three reference toxicants
    Fernando Martínez-Jerónimo
    Escuela Nacional de Ciencias Biologicas, I P N, Mexico
    J Environ Sci Health A Tox Hazard Subst Environ Eng 42:1417-24. 2007
    ..magna, an exotic cladoceran in Mexico. Considering its short life-cycle, C. dubia could be used in chronic toxicity tests, as well as in acute toxicity tests, having in both situations the advantage of requiring lower volumes of ..
  67. ncbi Comparative study of bioconcentration and EROD activity induction in the Japanese flounder, red sea bream, and Java medaka exposed to polycyclic aromatic hydrocarbons
    J Orkuma Cheikyula
    Department of Fisheries and Aquaculture, University of Agriculture, P M B 2373, Makurdi, Nigeria
    Environ Toxicol 23:354-62. 2008
    ..Due to its high PAH bioconcentration red sea bream is also recommended for consideration for biomonitoring and PAH chronic toxicity tests.
  68. ncbi Toxicity of trace metals in soil as affected by soil type and aging after contamination: using calibrated bioavailability models to set ecological soil standards
    Erik Smolders
    Division Soil and Water Management, University of Leuven, Kasteelpark Arenberg 20, 3001 Leuven, Belgium
    Environ Toxicol Chem 28:1633-42. 2009
    ..Bioavailability models have been calibrated using data from more than 500 new chronic toxicity tests in soils amended with soluble metal salts, in experimentally aged soils, and in field-contaminated soils...
  69. ncbi Assessing contaminant sensitivity of endangered and threatened aquatic species: part II. Chronic toxicity of copper and pentachlorophenol to two endangered species and two surrogate species
    J M Besser
    Columbia Environmental Research Center, United States Geological Survey, 4200 New Haven Rd, Columbia, Missouri 65201, USA
    Arch Environ Contam Toxicol 48:155-65. 2005
    ..Protectiveness of chronic water-quality criteria for threatened and endangered species could be improved by the use of safety factors or by conducting additional chronic toxicity tests with species and chemicals of concern.
  70. ncbi Acute lethal and teratogenic effects of tributyltin chloride and copper chloride on mahi mahi (Coryphaena hippurus) eggs and larvae
    Rachel Adema-Hannes
    Department of Biological Sciences, Florida Institute of Technology, Melbourne, Florida 32901, USA
    Environ Toxicol Chem 27:2131-5. 2008
    ..b>Chronic toxicity tests were used to determine the measurement of sublethal parameters, such as developmental abnormalities after ..
  71. ncbi Evaluating the risk to aquatic ecosystems posed by leachate from tire shred fill in roads using toxicity tests, toxicity identification evaluations, and groundwater modeling
    Patrick J Sheehan
    Exponent, 500 12th Street, Suite 220, Oakland, California 94607, USA
    Environ Toxicol Chem 25:400-11. 2006
    ..However, chronic toxicity tests with Ceriodaphnia dubia and fathead minnows (Pimephales promelas) showed no adverse effects caused by ..
  72. ncbi Chronic aquatic environmental risks from exposure to human pharmaceuticals
    Mark Crane
    Watts and Crane Associates, 23 London Street, Faringdon, Oxfordshire, SN7 7AG, UK
    Sci Total Environ 367:23-41. 2006
    ..b>Chronic toxicity tests with Cyanobacteria are likely to be sensitive surrogates for both algae and other unicellular organisms, ..
  73. ncbi Acutei and chronic toxicity of nickel to marine organisms: implications for water quality criteria
    John W Hunt
    University of California, Davis, Marine Pollution Studies Laboratory, Monterey 93940 9702, USA
    Environ Toxicol Chem 21:2423-30. 2002
    Acute and chronic toxicity tests were conducted to determine the effects of nickel on three U.S...
  74. ncbi Preliminary ecological risk assessment of butylparaben and benzylparaben -1. Removal efficiency in wastewater treatment, acute/chronic toxicity for aquatic organisms, and effects on medaka gene expression
    Hiroshi Yamamoto
    Department of Physical, Chemical, Geological and Environmental Sciences, Faculty of Integrated Arts and Sciences, The University of Tokushima, 1 1 Minamijosanjima cho, Tokushima, Japan
    Environ Sci 14:73-87. 2007
    ..Conventional acute/chronic toxicity tests were conducted using Japanese medaka (Oryzias latipes), daphnia (Daphnia magna), and green algae (..
  75. ncbi Cr(VI) reduction into Cr(III) as a mechanism to explain the low sensitivity of Vibrio fischeri bioassay to detect chromium pollution
    Elena Fulladosa
    Chemical Engineering Department, Universitat de Girona, Avda Lluís Santaló, s n 17071 Girona, Spain
    Chemosphere 65:644-50. 2006
    Vibrio fischeri bacteria, used as a biological target in either acute or chronic toxicity tests, display a low sensitivity to Cr(VI). This phenomenon could be due to the capacity of these bacteria to reduce Cr(VI) into Cr(III)...
  76. ncbi Ontogenic delays in effects of nitrite exposure on tiger salamanders (Ambystoma tigrinum tigrinum) and wood frogs (Rana sylvatica)
    Kerry L Griffis-Kyle
    Department of Biology, Syracuse University, 130 College Place, Syracuse, New York 13244, USA
    Environ Toxicol Chem 24:1523-7. 2005
    ..tigrinum tigrinum) embryos and young tadpoles and larvae to elevated concentrations of nitrite in chronic toxicity tests: 0, 0.3, 0.6, 1.2, 2.1, 4.6, and 6.1 mg/L NO2-N, exposing individuals as both embryos and larvae...
  77. ncbi Sediment chemical contamination and toxicity associated with a coastal golf course complex
    M A Lewis
    U S Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Gulf Ecology Division, 1 Sabine Island Drive, Gulf Breeze, Florida 32561 5299, USA
    Environ Toxicol Chem 20:1390-8. 2001
    ..It was concluded that the impact of golf course runoff on sediment quality may be subtle and sensitive biological assessment methods, such as chronic toxicity tests, will be needed to detect adverse effects.
  78. ncbi Initial ecological risk assessment of eight selected human pharmaceuticals in Japan
    Hiroshi Yamamoto
    Department of Physical, Chemical, Geological and Environmental Sciences, Faculty of Integrated Arts and Sciences, The University of Tokushima, Tokushima 770 8502, Japan
    Environ Sci 14:177-93. 2007
    ..suggest neither urgent nor severe concern for the ecological risk of these compounds, but further study needs to be conducted using chronic toxicity tests, including reproduction inhibition and endocrine disruption assessments.
  79. ncbi A Bayesian approach to analyzing ecotoxicological data
    Elise Billoir
    Universite de Lyon, F 69000, Lyon, France
    Environ Sci Technol 42:8978-84. 2008
    Standardized chronic toxicity tests are usually analyzed using a NOEC (no observed effect concentration) or ECx (x% effect concentration) calculation. However,these methods provide very little information for the material cost they entail...
  80. ncbi Multi-generation cadmium acclimation and tolerance in Daphnia magna Straus
    Brita T A Muyssen
    Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, J Plateaustraat 22, B 9000 Ghent, Belgium
    Environ Pollut 130:309-16. 2004
    ..93 nM Cd2+ were equally or more sensitive than non-acclimated daphnids in acute and chronic toxicity tests. Cadmium contents in D. magna increased significantly as a function of the acclimation concentration...
  81. ncbi Toxicity evaluation of the aqueous extract of the rhizome of Elephantorrhiza elephantina (Burch.) Skeels. (Fabaceae), in rats
    V Maphosa
    Department of Livestock and Pasture Sciences, University of Fort Hare, Alice 5700, South Africa
    Food Chem Toxicol 48:196-201. 2010
    ..As part of the safety assessment of the extract, acute, sub-acute and chronic toxicity tests were conducted by the oral route in rats...
  82. ncbi Acute and chronic aquatic toxicity structure-activity relationships for alcohol ethoxylates
    D D Morrall
    Miami Valley Laboratories, Environmental Science Department, The Procter and Gamble Company, P O Box 538707, Cincinnati, OH 45253 8707, USA
    Ecotoxicol Environ Saf 56:381-9. 2003
    Acute and chronic toxicity tests using the cladoceran Daphnia magna were conducted on several alcohol ethoxylate surfactants. Exposure and homologue distributions were confirmed using specific analytical methods...
  83. ncbi Towards environmental toxicogenomics -- development of a flow-through, high-density DNA hybridization array and its application to ecotoxicity assessment
    H L Fredrickson
    US Army Engineer Research and Development Center, Environmental Laboratory, Waterways Experiment Station, Vicksburg, MS 39180 6199, USA
    Sci Total Environ 274:137-49. 2001
    ..However, the time and cost of chronic toxicity tests limits their general application to higher levels of tiered toxicity assessments...
  84. ncbi Oxidative stress responses of Daphnia magna exposed to TiO(2) nanoparticles according to size fraction
    Ki Tae Kim
    Department of Environmental Science and Engineering, Gwangju Institute of Science and Technology GIST, 261 Cheom dan Gwagi ro, Buk Gu, Gwangju 500 712, South Korea
    Sci Total Environ 408:2268-72. 2010
    ..titanium dioxide nanoparticle (TiO(2) NP) exposure to Daphnia magna was investigated with both acute and chronic toxicity tests. Experiments on biochemical responses, repeatedly performed after size fractionation of the NPs using ..
  85. ncbi Assessment of the potential toxicity of a linear alkylbenzene sulfonate (LAS) to freshwater animal life by means of cladoceran bioassays
    Katiuscia da Silva Coelho
    Department of Ecology and Evolutionary Biology, Center of Biological Sciences and Health, Federal University of Sao Carlos, Rodovia Washington Luis, Sao Carlos, SP, Brazil
    Ecotoxicology 19:812-8. 2010
    ..17 mg L(-1) for D. similis, 11.84 mg L(-1) for C. dubia and 13.52 mg L(-1) for C. silvestrii. In the chronic toxicity tests performed on C. dubia and C...
  86. ncbi Development of a simulated earthworm gut for determining bioaccessible arsenic, copper, and zinc from soil
    Wai K Ma
    Department of Soil Science, University of Saskatchewan, 51 Campus Drive, Saskatoon, Saskatchewan S7N5A8, Canada
    Environ Toxicol Chem 28:1439-46. 2009
    ..The relevance of these SEG results will need validation through further comparison and correlation with bioaccumulation tests, alternative chemical extraction tests, and a battery of chronic toxicity tests with invertebrates and plants.
  87. ncbi Effects of temperature and salinity on life history of the marine amphipod Gammarus locusta. Implications for ecotoxicological testing
    T Neuparth
    Dep Ciências e Engenharia do Ambiente, Instituto do Mar IMAR, Fac Ciências e Tecnologia Universidade Nova de Lisboa, Monte de Caparica, Portugal
    Ecotoxicology 11:61-73. 2002
    ..Results also suggest that a multiple-response approach, including survival, growth and reproduction, should be applied in chronic toxicity tests.
  88. ncbi Absence of carcinogenic activity in Fischer rats and B6C3F1 mice following 103-week inhalation exposures to toluene
    James Huff
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Int J Occup Environ Health 9:138-46. 2003
    ..For mice, no biologically important increase was observed for any nonneoplastic or neoplastic lesion. Studies by others had reported carcinogenicity of toluene, especially for total malignant tumors...
  89. ncbi Cytokine profiling of chemical allergens in mice: impact of mitogen on selectivity of response
    Rebecca Jane Dearman
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M139PT, UK
    J Appl Toxicol 29:233-41. 2009
    ..These data demonstrate that the most optimal method for cytokine profiling is a chronic (13 day) exposure regime followed by culture of lymph node cells at 10(7 )cells ml(-1) for 120 h in the absence of mitogen...
  90. ncbi Toxicological evaluation of azumolene after repeated intraperitoneal administration in rats
    Paula Lima do Carmo
    Programa de Desenvolvimento de Fármacos, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Av Carlos Chagas 373, Sala 14, Bloco J, Centro de Ciencias da Saude, Cidade Universitaria, Rio de Janeiro, Brazil
    Fundam Clin Pharmacol 24:491-500. 2010
    ..p. injection of Az (2.5 mg/kg/day). In conclusion, Az is a safe compound for long-term administration, but does cause a mild, reversible reaction in skeletal muscle and kidney...
  91. pmc Influence of Helicobacter hepaticus infection on the chronic toxicity and carcinogenicity of triethanolamine in B6C3F1 mice
    Matthew D Stout
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 36:783-94. 2008
    ..These data suggest that in the initial study, H. hepaticusinfluenced the induction of hepatocellular neoplasms in males, but not in females...
  92. ncbi Inter-species differences in sensitivity to the calcemic activity of the novel 1,25-dihydroxyvitamin D3 analog BXL746
    Enrico Baroni
    Bioxell SpA, Department of Preclinical Development, Via Olgettina, 58, Milano 20132, Italy
    Regul Toxicol Pharmacol 52:332-41. 2008
    ..Our data indicate that the rat is a more relevant species than the dog for the prediction of human results when acute administration of a 1,25(OH)2D3 analog is envisaged...
  93. ncbi Temperature-dependent effects of cadmium on Daphnia magna: accumulation versus sensitivity
    Evelyn H W Heugens
    Department of Aquatic Ecology and Ecotoxicology, Faculty of Science, University of Amsterdam, P O Box 94084, 1090 GB Amsterdam, The Netherlands
    Environ Sci Technol 37:2145-51. 2003
    ..Since temperature has such a major impact on toxicity, a temperature correction may be necessary when translating toxicity data from the laboratory to the field...
  94. ncbi An analysis of the results from Two-Generation Reproduction Toxicity Studies to assess the value of mating animals of the second (F1) generation for the detection of adverse treatment-related effects on reproductive performance
    David P Myers
    Huntingdon Life Sciences, Eye, Suffolk IP23 7PX, UK
    Reprod Toxicol 26:47-50. 2008
    ..No effects were seen in the original parental (F0) generation which would have activated the change from a one- to a two-generation study...
  95. ncbi Lack of toxicity or carcinogenicity of S-170, a sucrose fatty acid ester, in F344 rats
    Midori Yoshida
    Department of Pathology, Sasaki Institute, 2 2 Kanda Surugadai, Chiyoda ku, Tokyo 101 0062, Japan
    Food Chem Toxicol 42:667-76. 2004
    ..37 g/kg/day in males and 2.80 g/kg/day in females, and 2.12 g/kg/day in males and 2.42 g/kg/day in females, respectively...
  96. ncbi Identification of phototransformation products of prednisone by sunlight: toxicity of the drug and its derivatives on aquatic organisms
    Marina Dellagreca
    Dipartimento di Chimica Organica e Biochimica, Universita Federico II, Via Cynthia 4, I 80126 Napoli, Italy
    Environ Toxicol Chem 22:534-9. 2003
    ..b>Chronic toxicity tests have been performed on the alga Pseudokirchneriella subcapitata (formerly known as Selenastrum ..
  97. ncbi [The estimation of molecular and cytogenetic effects in mice exposed to chronic low dose gamma-radiation]
    A N Osipov
    Moscow Research and Industrial Association Joint Ecological, Technological, and Research Center for the Radioactive Waste Neutralization and Environmental Control Radon, Russian Academy of Sciences, Moscow, Russia
    Genetika 38:1345-50. 2002
    ..On the day 210 of irradiation, the frequency of abnormal sperm heads in the mice significantly increased. The number of normochromatic micronucleated erythrocytes of the peripheral blood remained unchanged...
  98. ncbi Nonclinical safety of ziconotide: an intrathecal analgesic of a new pharmaceutical class
    Michael J Skov
    Elan Pharmaceuticals, Inc, South San Francisco, California 94080, USA
    Int J Toxicol 26:411-21. 2007
    ..In summary, the results from these nonclinical safety assessments revealed no significant toxicological risk to humans treated with ziconotide as recommended...
  99. ncbi Toxicity of a cadmium-contaminated diet to Hyalella azteca
    Angela L Ball
    Department of Biology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada
    Environ Toxicol Chem 25:2526-32. 2006
    Four- and 10-week chronic toxicity tests were conducted using the freshwater amphipod Hyalella azteca and Cd-contaminated Chlorella sp. as a food source. Chlorella sp...
  100. ncbi Chronic prenatal ethanol exposure increases glucocorticoid-induced glutamate release in the hippocampus of the near-term foetal guinea pig
    U Iqbal
    Department of Pharmacology and Toxicology, Queen s University, Kingston, Ontario, Canada
    J Neuroendocrinol 18:826-34. 2006
    ..These effects of CPEE, coupled with increased glutamate release and increased NMDA receptor expression, may predispose the near-term foetal hippocampus to GR and Glu-NMDA receptor-mediated neurodevelopmental toxicity...
  101. ncbi Thirteen-week repeated dose oral toxicity study of coenzyme Q10 in rats
    Kumiko Honda
    J Toxicol Sci 32:437-48. 2007
    ..Based on these results, the non-observed-adverse-effect level (NOAEL) of Coenzyme Q10 was considered to be 1200 mg/kg/day for male and female rats under these study conditions...

Research Grants15

  1. Synaptosomal Protein Changes After EtOH Self-Administration
    Frank Witzmann; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  2. CHEMICAL DISPOSITION IN MAMMALS SRI INTERNATIONAL
    Carol Green; Fiscal Year: 2000
    ..is being studied to provide data to determine the appropriate route of exposure for the subchronic and chronic toxicity tests. Four peroxisome proliferators, dibutyl phthalate, Wyeth 14,643, 2,4-dichlorophenoxyacetic acid, and ..
  3. Pharmacogenomics/natural products + antifungal activity
    John Cleary; Fiscal Year: 2004
    ..Traditional drug development processes utilize batteries of acute and chronic toxicity tests to evaluate safety...
  4. Drug Abuse Vulnerability: Role of Development and Gender
    Lisa M Schrott; Fiscal Year: 2010
    ....
  5. METHANOL EXPOSURE EFFECTS ON PRIMATE DEVELOPMENT
    THOMAS BURBACHER; Fiscal Year: 2001
    ....
  6. MECHANISMS OF IMMUNOSUPPRESSION BY ONE DOSE OF ETHANOL
    Stephen Pruett; Fiscal Year: 2007
    ..abstract_text> ..
  7. Mechanisms of Immunotoxcity of Chemical Stressors
    Stephen Pruett; Fiscal Year: 2005
    ....
  8. TOXICOLOGY FOR TEACHERS
    Ann de Peyster; Fiscal Year: 2003
    ..These workshops are an innovative way for scientists and teachers to work together to improve science education. ..
  9. DEVELOPMENTAL EFFECTS OF METHYLMERCURY
    THOMAS BURBACHER; Fiscal Year: 2002
    ..The proposed studies take full advantage of the history of these monkeys and represents the best possible use of this valuable resource. ..
  10. Mechanisms of methyl dithiocarbamate immunotoxicity
    Stephen B Pruett; Fiscal Year: 2010
    ..It is also expected that the detailed study of three important mechanisms of action, which will be examined in each aim, can be generalized to other situations or toxicants that alter these parameters. ..
  11. Protein Biomarker Profiles of Abusive Alcohol Consumption
    Frank Witzmann; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  12. CHEMICAL INDUCED NEPHROTOXICITY--SUCCINIMIDES
    GARY RANKIN; Fiscal Year: 2001
    ..Collectively, the results of these studies should add important, new knowledge about the nephrotoxic and urotoxic species of succinimides, cellular targets of the toxicant species and potential mechanisms of nephrotoxicity. ..
  13. ABUSED DRUGS AND DEVELOPMENT OF THE NEUROIMMUNE AXIS
    LISA SCHROTT; Fiscal Year: 2002
    ....