substance abuse detection

Summary

Summary: Detection of drugs that have been abused, overused, or misused, including legal and illegal drugs. Urine screening is the usual method of detection.

Top Publications

  1. ncbi Evaluation of the DRI oxycodone immunoassay for the detection of oxycodone in urine
    Ronald C Backer
    Ameritox Limited, Midland, Texas, USA
    J Anal Toxicol 29:675-7. 2005
  2. ncbi Determination of ketamine and norketamine in hair by gas chromatography/mass spectrometry using two-step derivatization
    Jin Young Kim
    Rapid Commun Mass Spectrom 20:3159-62. 2006
  3. ncbi Barriers to implementing screening and brief interventions in general practice: findings from a qualitative study in Norway
    Peter Nygaard
    1Norwegian Institute for Alcohol and Drug Research SIRUS, P B 565 Sentrum, 0105 Oslo, Norway
    Alcohol Alcohol 46:52-60. 2011
  4. ncbi A review of the methods, interpretation, and limitations of the urine drug screen
    E Claire Markway
    Department of Pharmacy Services, University of Kentucky, Lexington, Kentucky, USA
    Orthopedics 34:877-81. 2011
  5. ncbi Assessment of exposure to opiates and cocaine during pregnancy in a Mediterranean city: preliminary results of the "Meconium Project"
    Simona Pichini
    Drug Research and Evaluation Department, Istituto Superiore di Sanita, Rome, Italy
    Forensic Sci Int 153:59-65. 2005
  6. ncbi Naltrexone for the treatment of amphetamine dependence: a randomized, placebo-controlled trial
    Nitya Jayaram-Lindström
    Department of Clinical Neuroscience, Division of Psychiatry, Karolinska Institutet, Stockholm, Sweden
    Am J Psychiatry 165:1442-8. 2008
  7. ncbi How to screen for problematic cannabis use in population surveys: an evaluation of the Cannabis Use Disorders Identification Test (CUDIT) in a Swiss sample of adolescents and young adults
    B Annaheim
    Swiss Institute for the Prevention of Alcohol and Drug Problems, Lausanne, Switzerland
    Eur Addict Res 14:190-7. 2008
  8. ncbi Driving under the influence of drugs -- evaluation of analytical data of drugs in oral fluid, serum and urine, and correlation with impairment symptoms
    Stefan W Toennes
    Institute of Forensic Toxicology, Center of Legal Medicine, Kennedyallee 104, D 60596 Frankfurt Main, Germany
    Forensic Sci Int 152:149-55. 2005
  9. pmc Oral fluid testing for drugs of abuse
    Wendy M Bosker
    Maastricht University, Neuropsychology and Psychopharmacology, Experimental Psychopharmacology Unit, Maastricht, The Netherlands
    Clin Chem 55:1910-31. 2009
  10. ncbi Detection times of drugs of abuse in blood, urine, and oral fluid
    Alain G Verstraete
    Clinical Biology Laboratory, Ghent University Hospital, B 9000 Ghent, Belgium
    Ther Drug Monit 26:200-5. 2004

Detail Information

Publications223 found, 100 shown here

  1. ncbi Evaluation of the DRI oxycodone immunoassay for the detection of oxycodone in urine
    Ronald C Backer
    Ameritox Limited, Midland, Texas, USA
    J Anal Toxicol 29:675-7. 2005
    ..From the presented study, the sensitivity of the DRI-Oxy was 0.991 and the selectivity 0.998. The DRI-Oxy assay provided a highly reliable method for the detection of oxycodone and/or oxymorphone in urine specimens...
  2. ncbi Determination of ketamine and norketamine in hair by gas chromatography/mass spectrometry using two-step derivatization
    Jin Young Kim
    Rapid Commun Mass Spectrom 20:3159-62. 2006
  3. ncbi Barriers to implementing screening and brief interventions in general practice: findings from a qualitative study in Norway
    Peter Nygaard
    1Norwegian Institute for Alcohol and Drug Research SIRUS, P B 565 Sentrum, 0105 Oslo, Norway
    Alcohol Alcohol 46:52-60. 2011
    ....
  4. ncbi A review of the methods, interpretation, and limitations of the urine drug screen
    E Claire Markway
    Department of Pharmacy Services, University of Kentucky, Lexington, Kentucky, USA
    Orthopedics 34:877-81. 2011
    ..Either gas chromatography or high-performance liquid chromatography can be used to confirm positive results...
  5. ncbi Assessment of exposure to opiates and cocaine during pregnancy in a Mediterranean city: preliminary results of the "Meconium Project"
    Simona Pichini
    Drug Research and Evaluation Department, Istituto Superiore di Sanita, Rome, Italy
    Forensic Sci Int 153:59-65. 2005
    ..Of the four newborns exposed to arecoline, one showed a low birth weight, low intrauterine growth, hyporeflexia and hypotonia...
  6. ncbi Naltrexone for the treatment of amphetamine dependence: a randomized, placebo-controlled trial
    Nitya Jayaram-Lindström
    Department of Clinical Neuroscience, Division of Psychiatry, Karolinska Institutet, Stockholm, Sweden
    Am J Psychiatry 165:1442-8. 2008
    ..The aim of this study was to investigate the efficacy of naltrexone in comparison with placebo in reducing relapse to amphetamine use in amphetamine-dependent patients...
  7. ncbi How to screen for problematic cannabis use in population surveys: an evaluation of the Cannabis Use Disorders Identification Test (CUDIT) in a Swiss sample of adolescents and young adults
    B Annaheim
    Swiss Institute for the Prevention of Alcohol and Drug Problems, Lausanne, Switzerland
    Eur Addict Res 14:190-7. 2008
    ..The Cannabis Use Disorders Identification Test (CUDIT) is a 10-item questionnaire used for screening cannabis abuse and dependency. The present study evaluated that screening instrument...
  8. ncbi Driving under the influence of drugs -- evaluation of analytical data of drugs in oral fluid, serum and urine, and correlation with impairment symptoms
    Stefan W Toennes
    Institute of Forensic Toxicology, Center of Legal Medicine, Kennedyallee 104, D 60596 Frankfurt Main, Germany
    Forensic Sci Int 152:149-55. 2005
    ..7%). The data demonstrate that oral fluid is superior to urine in correlating with serum analytical data and impairment symptoms of drivers under the influence of drugs of abuse...
  9. pmc Oral fluid testing for drugs of abuse
    Wendy M Bosker
    Maastricht University, Neuropsychology and Psychopharmacology, Experimental Psychopharmacology Unit, Maastricht, The Netherlands
    Clin Chem 55:1910-31. 2009
    ..Although OF testing is now commonplace in many monitoring programs, the greatest current limitation is the scarcity of controlled drug administration studies available to guide interpretation...
  10. ncbi Detection times of drugs of abuse in blood, urine, and oral fluid
    Alain G Verstraete
    Clinical Biology Laboratory, Ghent University Hospital, B 9000 Ghent, Belgium
    Ther Drug Monit 26:200-5. 2004
    ..The duration of detection of GHB is much shorter. After a single dose of 1 or 2 ng of flunitrazepam, the most sensitive methods can detect 7-aminoflunitrazepam for up to 4 weeks in urine...
  11. pmc Drug use in English professional football
    I Waddington
    University College Chester, UK
    Br J Sports Med 39:e18; discussion e18. 2005
    ....
  12. ncbi Developing limits for driving under cannabis
    Franjo Grotenhermen
    Nova Institut, Hürth, Germany
    Addiction 102:1910-7. 2007
    ..Development of a rational and enforceable basis for controlling the impact of cannabis use on traffic safety...
  13. ncbi Development of a self-report screening instrument for assessing potential opioid medication misuse in chronic pain patients
    Laura L Adams
    The Eugene McDermott Center for Pain, The University of Texas Southwestern Medical Center at Dallas, 75390, USA
    J Pain Symptom Manage 27:440-59. 2004
    ..Future psychometric analyses will consider predictive validity and examine shortened versions of the instrument...
  14. ncbi Oral fluid testing for driving under the influence of drugs: history, recent progress and remaining challenges
    Alain G Verstraete
    Laboratory of Clinical Biology, Ghent University Hospital and Faculty of Medicine and Health Sciences, Ghent University, De Pintelaan 185, B 9000 Ghent, Belgium
    Forensic Sci Int 150:143-50. 2005
    ....
  15. pmc Cannabis use and the GP: brief motivational intervention increases clinical enquiry by GPs in a pilot study
    Jim McCambridge
    National Addiction Centre, Maudsley Institute of Psychiatry, Addiction Sciences Building, 4 Windsor Walk, Denmark Hill, London SE5 8AF
    Br J Gen Pract 53:637-9. 2003
    ..Substantially more positive attitudes and greater clinical activity were observed following receipt of intervention...
  16. ncbi The relationship between performance on the standardised field sobriety tests, driving performance and the level of Delta9-tetrahydrocannabinol (THC) in blood
    K Papafotiou
    Swinburne Centre for Neuropsychology, Swinburne University of Technology, PO Box 218, Hawthorn, Vic 3122, Australia
    Forensic Sci Int 155:172-8. 2005
    ....
  17. ncbi Prevalence of illicit drug use among the Italian athlete population with special attention on drugs of abuse: a 10-year review
    Sabina Strano Rossi
    Laboratorio Antidoping, Federazione Medico Sportiva Italiana, Rome, Italy
    J Sports Sci 29:471-6. 2011
    ..However, due to the particular population studied, it must be considered an underestimation of the phenomenon among elite athletes with respect to the general population...
  18. ncbi Toward a more parsimonious approach to drug recognition expert evaluations
    Amy J Porath-Waller
    Canadian Centre on Substance Abuse, Ottawa, Ontario K1P 5E7, Canada
    Traffic Inj Prev 10:513-8. 2009
    ..The purpose of this study is to statistically identify the set of drug-related cues from Drug Evaluation and Classification (DEC) evaluations that significantly predict the substance used by suspected drug-impaired drivers...
  19. ncbi Analytical toxicology
    Hans H Maurer
    Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, Saarland University, Homburg, Germany
    EXS 100:317-37. 2010
    ..The importance of quality control and possibilities and limitations of interpretation of the analytical result are also discussed...
  20. ncbi Evaluation of on-site oral fluid screening using Drugwipe-5(+), RapidSTAT and Drug Test 5000 for the detection of drugs of abuse in drivers
    Sarah M R Wille
    Federal Public Service Justice, National Institute of Criminalistics and Criminology, Vilvoordsesteenweg 100, Brussels, Belgium
    Forensic Sci Int 198:2-6. 2010
    ..They believe that their ease of use and diminished amount of false positive results in comparison with urine screening will lead to more roadside tests and more appropriate juridical measures...
  21. pmc Using molecular similarity to highlight the challenges of routine immunoassay-based drug of abuse/toxicology screening in emergency medicine
    Matthew D Krasowski
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
    BMC Emerg Med 9:5. 2009
    ..For immunoassays targeted at a particular class of drugs, there can also be false negatives if there is failure to detect some drugs or their metabolites within that class...
  22. ncbi Impact of a reduction in heroin availability on patterns of drug use, risk behaviour and incidence of hepatitis C virus infection in injecting drug users in New South Wales, Australia
    Lisa Maher
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, St Vincent s Medical Centre, 376 Victoria Street, Darlinghurst, Sydney, NSW 10, Australia
    Drug Alcohol Depend 89:244-50. 2007
    ....
  23. ncbi Development of a metabolomic approach based on liquid chromatography-high resolution mass spectrometry to screen for clenbuterol abuse in calves
    Frédérique Courant
    Laboratoire d Etude des Résidus et Contaminants dans les Aliments LABERCA, Ecole Nationale Vétérinaire de Nantes ENVN, USC INRA 2013, BP 50707, F 44307 Nantes Cedex 3, France
    Analyst 134:1637-46. 2009
    ..This new approach may be considered of valuable interest to overcome current limitations in the control of growth promoters' abuse, with promising perspectives in terms of screening...
  24. ncbi Validation of an ELISA-based screening assay for the detection of amphetamine, MDMA and MDA in blood and oral fluid
    Marleen Laloup
    Federal Public Service Justice, National Institute of Criminalistics and Criminology NICC, Section Toxicology, Vilvoordsesteenweg 98, 1120 Brussels, Belgium
    Forensic Sci Int 153:29-37. 2005
    ..It should be emphasized that method validation should be performed for each type of biological matrix...
  25. ncbi Testing for substance use in trauma patients: are we doing enough?
    Jason A London
    Division of Trauma and Emergency Surgery, Department of Surgery, University of California, Davis Medical Center, Sacramento, CA 95817, USA
    Arch Surg 142:633-8. 2007
    ..Only a fraction of trauma patients are being tested for substance use, and the proportion of those tested may have decreased over time...
  26. ncbi The 3-metros study of drugs and crime in South Africa: findings and policy implications
    Charles D Parry
    Alcohol and Drug Abuse Research Group, Medical Research Council, P O Box 19070, Tygerberg Cape Town, 7505, South Africa
    Am J Drug Alcohol Abuse 30:167-85. 2004
    ....
  27. ncbi Testing for fetal exposure to illicit drugs using umbilical cord tissue vs meconium
    D Montgomery
    Department of Women and Newborns, Intermountain Health Care and McKay Dee Hospital, Ogden, UT 84403, and Department of Family and Preventive Medicine, University of Utah, Salt Lake City, UT, USA
    J Perinatol 26:11-4. 2006
    ..We assessed the agreement of testing for fetal exposure to illicit drugs contrasting paired specimens of meconium vs umbilical cord tissue...
  28. ncbi Evaluation of indirect biomarkers for detecting corticosteroids used as illegal growth promoters in beef cattle
    M Vascellari
    Department of Histopathology, Istituto Zooprofilattico Sperimentale delle Venzie, Via dell Università 10, 35020 Legnaro, Padova, Italy
    Vet Rec 163:147-51. 2008
    ..The samples that were positive by chemical analysis had cortisol concentrations of less than 2.0 ng/ml, whereas the mean cortisol concentration of the negative samples was 10.3 ng/ml...
  29. ncbi Drug screening of preserved oral fluid by liquid chromatography-tandem mass spectrometry
    Elisabeth Leere Øiestad
    Norwegian Institute of Public Health, Division of Forensic Toxicology and Drug Abuse, Oslo, Norway
    Clin Chem 53:300-9. 2007
    ..Development of methods for extensive drug screening in oral fluid is warranted...
  30. pmc Biological markers of drug use in the club setting
    Brenda A Miller
    Prevention Research Center, Pacific Institute for Research and Evaluation PIRE, 1995 University Avenue, Suite 450, Berkeley, California 94704, USA
    J Stud Alcohol Drugs 70:261-8. 2009
    ..The prevalence of drug and alcohol use among patrons of clubs featuring electronic music dance events was determined by using biological assays at entrance and exit...
  31. pmc Identification of prenatal amphetamines exposure by maternal interview and meconium toxicology in the Infant Development, Environment and Lifestyle (IDEAL) study
    Teresa R Gray
    Chemistry and Drug Metabolism, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA
    Ther Drug Monit 31:769-75. 2009
    ..Low confirmation rates in meconium reinforce the need for confirmatory testing following positive screening results and additional research to identify alternative biomarkers...
  32. ncbi Toxicology screening results: injury associations among hospitalized trauma patients
    Richard D Blondell
    Department of Family Medicine, State University of New York, University at Buffalo, 14215 3021, USA
    J Trauma 58:561-70. 2005
    ..Substance abuse is associated with injuries, but these associations have not been well characterized by type of substance and injury type...
  33. ncbi A search for guidance: examining prenatal substance exposure protocols
    Gail L Zellman
    RAND, Santa Monica, California 90407 2138, USA
    Matern Child Health J 6:205-12. 2002
    ..To describe key elements of a set of hospital prenatal substance exposure protocols, and to relate variations in protocol content to the state legislative environment and hospital characteristics...
  34. ncbi Neonatal illicit drug screening practices in Iowa: the impact of utilization of a structured screening protocol
    R Oral
    Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Perinatol 26:660-6. 2006
    ..The purpose of the study was to determine the neonatal illicit drug screening practices of Iowa birthing hospitals...
  35. ncbi Using umbilical cord tissue to detect fetal exposure to illicit drugs: a multicentered study in Utah and New Jersey
    D P Montgomery
    Department of Women and Newborns, Intermountain Healthcare, Salt Lake City, UT 84403, USA
    J Perinatol 28:750-3. 2008
    ..We assessed umbilical cord tissue as a means of detecting fetal exposure to five classes of drugs of abuse...
  36. ncbi Unsuspected exposure to cocaine in preschool children from a Mediterranean city detected by hair analysis
    Xavier Joya
    Unitat de Recerca Infancia i Entorn, Institut Municipal d Investigació Mèdica Hospital del Mar, Barcelona, Spain
    Ther Drug Monit 31:391-5. 2009
    ..In the light of these results, we advocate general hair screening to disclose exposure to cocaine and other drugs of abuse in children from risky environments, which could provide the basis for specific social and health interventions...
  37. ncbi Substance abuse treatment linked with prenatal visits improves perinatal outcomes: a new standard
    N C Goler
    Department of Obstetrics and Gynecology, The Permanente Medical Group, Northern California Region, Vallejo, CA 94590 2406, USA
    J Perinatol 28:597-603. 2008
    ..To evaluate the impact of Early Start, an obstetric clinic-based prenatal substance abuse treatment program, on perinatal outcomes...
  38. ncbi Multi-residue screening of a minimum package of anabolic steroids in urine with GC-MS
    P R Kootstra
    RIVM, National Institute of Public Health and the Environment, Laboratory for Food and Residue Analyses, European Union Community Reference Laboratory, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Anal Chim Acta 586:82-92. 2007
    ..Results of validation experiments are presented. The method is flexible and due to the non-specific sample clean-up more and new anabolic compounds can be easily added in order to new monitoring requirements...
  39. ncbi Amphetamine excretion profile following multidose administration of mixed salt amphetamine preparation
    John T Cody
    Academy of Health Sciences, MCCS HMP PA Branch, Fort Sam Houston, Texas 78234 6138, USA
    J Anal Toxicol 28:563-74. 2004
    ..Coupling this data with drug concentration makes it possible for forensic toxicologists and MROs to come to an informed decision regarding the involvement of this drug in a positive drug test result...
  40. ncbi Fast gas chromatographic/mass spectrometric determination of diuretics and masking agents in human urine: Development and validation of a productive screening protocol for antidoping analysis
    V Morra
    Consorzio Piemontese per la Prevenzione e Repressione del Doping e di altri Usi Illeciti dei Farmaci, Regione Gonzole 10, 10043 Orbassano, Turin, Italy
    J Chromatogr A 1135:219-29. 2006
    ..Fast quadrupole MS electronics allows high scan rates and effective data acquisition both in scan and selected ion monitoring modes...
  41. ncbi Metabolism and excretion of anabolic steroids in doping control--new steroids and new insights
    Peter Van Eenoo
    Doping control laboratory DoCoLab, Ghent University Ugent, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    J Steroid Biochem Mol Biol 101:161-78. 2006
    ..Additionally an update and insight on new aspects for "older" steroids with respect to doping control is given...
  42. ncbi Urine benzodiazepine screening using Roche Online KIMS immunoassay with beta-glucuronidase hydrolysis and confirmation by gas chromatography- mass spectrometry
    Kevin L Klette
    Navy Drug Screening Laboratory, 320 B Street, Great Lakes, Illinois 60088 2815, USA
    J Anal Toxicol 29:193-200. 2005
    ..The Online BZD IA modified by the automatic addition of beta-glucuronidase appears well adapted for the rapid detection of BZDs and their metabolites in human urine...
  43. pmc Erythropoietin and blood doping
    N Robinson
    Swiss Laboratory for Doping Analyses, Institute of Legal Medicine, Lausanne, Switzerland
    Br J Sports Med 40:i30-4. 2006
    ..To outline the direct and indirect approaches in the fight against blood doping in sports, the different strategies that have been used and are currently being used to fight efficiently against blood doping are presented and discussed...
  44. ncbi Use of isotope ratio mass spectrometry to detect doping with oral testosterone undecanoate: inter-individual variability of 13C/12C ratio
    Norbert Baume
    Laboratoire Suisse d Analyse du Dopage, Institut Universitaire de Medecine Legale, Lausanne, Switzerland
    Steroids 71:364-70. 2006
    ..According to T/E ratios and delta(13)C-values, the washout period after 80 mg TU intake was less than 48 h for all subjects and no accumulation phenomenon was observed upon chronic oral administration...
  45. pmc Injectable, sustained-release naltrexone for the treatment of opioid dependence: a randomized, placebo-controlled trial
    Sandra D Comer
    Division on Substance Abuse, New York State Psychiatric Institute, and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York 10032, USA
    Arch Gen Psychiatry 63:210-8. 2006
    ..Oral naltrexone can completely antagonize the effects produced by opioid agonists. However, poor compliance with naltrexone has been a major obstacle to the effective treatment of opioid dependence...
  46. ncbi Validation and application of a screening method for beta2-agonists, anti-estrogenic substances and mesocarb in human urine using liquid chromatography/tandem mass spectrometry
    Min Jung Kang
    Bioanalysis and Biotransformation Center, Korea Institute of Science and Technology, 130 650, Hawolgokdong 39 1, Seoul, Korea
    Rapid Commun Mass Spectrom 21:252-64. 2007
    ..8%. The limit of detection was below 10 ng/mL except formestane (300 ng/mL) and aminoglutethimide (100 ng/mL). The validated method was applied for the analysis of excretion samples...
  47. ncbi Detection and quantification of glucuro- and sulfoconjugated metabolites in human urine following oral administration of xenobiotic 19-norsteroids
    Y L Tseng
    Institute of Pharmacology and Toxicology, Tzu Chi University, 701 Chung Yan Road, Sec 3, Hualien 970, Taiwan
    Steroids 71:817-27. 2006
    ..Results from the excretion studies demonstrate significance of sulfate-conjugated metabolites on interpretation of misuse of the 19-norsteroids...
  48. ncbi Distribution of methylenedioxymethamphetamine (MDMA) and methylenedioxyamphetamine (MDA) in postmortem and antemortem specimens
    Ray H Liu
    Department of Forensic Toxicology, Institute of Forensic Medicine, Ministry of Justice, Taipei, Taiwan
    J Anal Toxicol 30:545-50. 2006
    ..This observation is consistent with the relative drug/metabolite incorporation rates reported for cocaine/benzoylecgonine, tetrahydrocannabinol/tetrahydrocannabinoic acid, and MDMA/MDA...
  49. ncbi False positive phencyclidine results caused by venlafaxine
    Patricio Molero Santos
    Am J Psychiatry 164:349. 2007
  50. ncbi Urine drug screening: practical guide for clinicians
    Karen E Moeller
    University of Kansas Medical Center, Kansas City, KS 66160 7231, USA
    Mayo Clin Proc 83:66-76. 2008
    ..Other pitfalls, such as adulteration, substitution, and dilution of urine samples, are discussed. Pragmatic concepts summarized in this article should minimize the potential risks of misinterpreting urine drug screens...
  51. pmc Cocaine and metabolites urinary excretion after controlled smoked administration
    Marilyn A Huestis
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Anal Toxicol 31:462-8. 2007
    ..T(max) was not dose-dependent. All metabolites were detected in some subjects within 2 h. EC concentrations were significantly higher after smoked cocaine in a precise delivery coil compared to a glass "crack" pipe...
  52. ncbi Introduction of HPLC/orbitrap mass spectrometry as screening method for doping control
    E D Virus
    Moscow Antidoping Center, Elizavetynsky10, 105005, Moscow, Russia
    J Mass Spectrom 43:949-57. 2008
    ..The relative standard deviation (RSD) of the intraday precision (n = 6) ranged from RSD = 16-22%, whereas the interday precision (n = 18), ranged from RSD = 17-26%, depending on the solute concentration investigated...
  53. ncbi Elimination of 7-aminoclonazepam in urine after a single dose of clonazepam
    Adam Negrusz
    Department of Biopharmaceutical Sciences M C 865, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA
    Anal Bioanal Chem 376:1198-204. 2003
    ..The range of concentrations detected was from 73.0 pg x mL(-1) to 183.2 ng x mL(-1). CLO was not detected in any of the samples...
  54. ncbi Sports drug testing--an analyst's perspective
    Graham J Trout
    Australian Sports Drug Testing Laboratory, Australian Government Analytical Laboratories, Sydney, Australia
    Chem Soc Rev 33:1-13. 2004
    ..The contest between those who wish to cheat and those who wish to maintain fair play in sport is an ongoing one...
  55. ncbi National academy of clinical biochemistry laboratory medicine practice guidelines: recommendations for the use of laboratory tests to support poisoned patients who present to the emergency department
    Alan H B Wu
    Department of Pathology and Laboratory Medicine, Hartford Hospital, Hartford, CT 06102, USA
    Clin Chem 49:357-79. 2003
    ..Exposure to drugs and toxins is a major cause for patients' visits to the emergency department (ED)...
  56. ncbi Screening for 18 diuretics and probenecid in doping analysis by liquid chromatography-tandem mass spectrometry
    K Deventer
    Ghent University, Doping Control Unit, Faculty of Veterinary Medicine, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Biomed Chromatogr 16:529-35. 2002
    ..All diuretics could be detected for periods up to 96 h after the intake of therapeutic amounts...
  57. doi Doping: a paradigm shift has taken place in testing
    Pierre Edouard Sottas
    Nature 455:166. 2008
  58. ncbi Carbon isotope ratio (delta13C) values of urinary steroids for doping control in sport
    Adam T Cawley
    Australian Sports Drug Testing Laboratory ASDTL, National Measurement Institute NMI, 1 Suakin Street, Pymble, NSW 2073, Australia
    Steroids 74:379-92. 2009
    ....
  59. ncbi Quinolones and false-positive urine screening for opiates by immunoassay technology
    L R Baden
    Division of Infectious Diseases, Brigham and Women s Hospital, 15 Francis St, PBB A400, Boston, MA 02115, USA
    JAMA 286:3115-9. 2001
    ..Millions of assays are performed each year to monitor for substance abuse in various settings. When common medications cross-react with frequently used testing assays, false-positive results can lead to invalid conclusions...
  60. ncbi Urine drug screening in the medical setting
    Catherine A Hammett-Stabler
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA
    Clin Chim Acta 315:125-35. 2002
    ..The reasons for these include the drugs involved, the sample, the methods utilized to perform the tests, and the level of understanding of the physician using the data, all of which are closely related to the other...
  61. ncbi Analysis of exogenous dehydroepiandrosterone excretion in urine by gas chromatography/combustion/isotope ratio mass spectrometry
    M Ueki
    Doping Control Laboratory, Mitsubishi Kagaku Bio Clinical Laboratories, Inc, 3 30 1 Shimura, Itabashi ku, Tokyo 174 8555, Japan
    Rapid Commun Mass Spectrom 13:2237-43. 1999
    ..Thus, the deviations in delta-values of DHEA and its diol metabolites are considered to be conclusive evidence for detecting doping with DHEA. Some successful cases of detection of doping with DHEA from athletes are also reported...
  62. ncbi Evaluation of testosterone/epitestosterone ratio influential factors as determined in doping analysis
    D H van de Kerkhof
    Utrecht Institute of Pharmaceutical Sciences, Department of Human Toxicology, University of Utrecht, The Netherlands
    J Anal Toxicol 24:102-15. 2000
    ....
  63. ncbi A marijuana screening inventory (experimental version): description and preliminary psychometric properties
    Dale Alexander
    Graduate School of Social Work, University of Houston, Houston, Texas 77204 4013, USA
    Am J Drug Alcohol Abuse 29:619-46. 2003
    ..This article describes the Marijuana Screening Inventory (MSI-X) and its preliminary psychometric reliability, factor analyses, and factor structure...
  64. ncbi Identification and measurement of illicit drugs and their metabolites in urban wastewater by liquid chromatography-tandem mass spectrometry
    Sara Castiglioni
    Department of Environmental Health Sciences, Mario Negri Institute for Pharmacological Research, Via Eritrea 62, 20157 Milan, Italy
    Anal Chem 78:8421-9. 2006
    ..As previously reported for cocaine, this method could be useful to estimate and monitor drug consumption in the population in real time, helping social scientists and authorities to combat drug abuse...
  65. ncbi Analytical techniques for drug detection in oral fluid
    Pirjo Lillsunde
    National Public Health Institute, Drug Research Unit, Helsinki, Finland
    Ther Drug Monit 30:181-7. 2008
    ..Several sensitive methods for drug testing in OF have been developed during the last years...
  66. ncbi The reliability and validity of the Severity of Dependence Scale for detecting cannabis dependence in psychosis
    L Hides
    School of Applied Psychology, Griffith University, Australia
    Addiction 102:35-40. 2007
    ..To determine the reliability and validity of the Severity of Dependence Scale (SDS) for detecting cannabis dependence in a large sample of in-patients with a schizophrenia spectrum disorder...
  67. ncbi Prevalence of cocaine and marijuana use in the last trimester of adolescent pregnancy: socio-demographic, psychosocial and behavioral characteristics
    Sandro Sendin Mitsuhiro
    Alcohol and Drug Research Unit UNIAD, Psychiatry Department, Federal University of Sao Paulo, Rua Botucatu, 394, 04023 061, Brazil
    Addict Behav 32:392-7. 2007
    ....
  68. ncbi A high-throughput multicomponent screening method for diuretics, masking agents, central nervous system (CNS) stimulants and opiates in human urine by UPLC-MS/MS
    John Olof Thorngren
    Doping Control Laboratory, Karolinska University Hospital, Huddinge, Sweden
    J Mass Spectrom 43:980-92. 2008
    ..The report can also be processed automatically using an application software, which interpret the data and indicate if there is a suspicious sample. One 96-well plate can be analyzed within 16 h...
  69. ncbi Mass spectrometry in sports drug testing: Structure characterization and analytical assays
    Mario Thevis
    Institute of Biochemistry and Center for Preventive Doping Research, German Sport University Cologne, Carl Diem Weg 6, 50933 Cologne, Germany
    Mass Spectrom Rev 26:79-107. 2007
    ....
  70. ncbi Isotopic pattern and accurate mass determination in urine drug screening by liquid chromatography/time-of-flight mass spectrometry
    Suvi Ojanperä
    Department of Forensic Medicine, University of Helsinki, Helsinki, Finland
    Rapid Commun Mass Spectrom 20:1161-7. 2006
    ..The results show that isotopic pattern matching by SigmaFit is a powerful means of identification in addition to accurate mass measurement...
  71. ncbi Performance characteristics of a carbon isotope ratio method for detecting doping with testosterone based on urine diols: controls and athletes with elevated testosterone/epitestosterone ratios
    R Aguilera
    UCLA Olympic Analytical Laboratory, Department of Molecular and Medical Pharmacology, University of California at Los Angeles, Los Angeles, CA 90025, USA
    Clin Chem 47:292-300. 2001
    ..Carbon isotope ratio methods are used in doping control to determine whether urinary steroids are endogenous or pharmaceutical...
  72. ncbi Behavioral monitoring and urine toxicology testing in patients receiving long-term opioid therapy
    Nathaniel P Katz
    Pain Trials Center, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Anesth Analg 97:1097-102, table of contents. 2003
    ..Requiring a report of behavioral issues and urine toxicology screens for patients receiving chronic opioids creates a more comprehensive monitoring system than either alone...
  73. ncbi From population- to subject-based limits of T/E ratio to detect testosterone abuse in elite sports
    Pierre Edouard Sottas
    Swiss Laboratory for Doping Analyses, Institut de Medecine Legale, Universite de Lausanne, Chemin des Croisettes 22, 1066 Epalinges, Switzerland
    Forensic Sci Int 174:166-72. 2008
    ..We found that this screening test heightens drastically the capacity to detect testosterone abuse, at no additional financial and administrative expenses for anti-doping authorities...
  74. ncbi A general screening method for doping agents in human urine by solid phase extraction and liquid chromatography/time-of-flight mass spectrometry
    Marjo Kolmonen
    Forensic Toxicology Division, Department of Forensic Medicine, University of Helsinki, Finland
    Anal Chim Acta 585:94-102. 2007
    ..The suitability of the LC/TOFMS method for doping control was demonstrated with authentic urine samples...
  75. ncbi Multi-detection of corticosteroids in sports doping and veterinary control using high-resolution liquid chromatography/time-of-flight mass spectrometry
    M E Touber
    RIKILT Institute of Food Safety, P O Box 230, Wageningen, 6700 AE, The Netherlands
    Anal Chim Acta 586:137-46. 2007
    ..4 microg L(-1), respectively. The method can be easily extended with other banned substances of interest, as demonstrated by the addition of 21 beta2-agonists to the original analyte mixture in urine, without causing any interferences...
  76. ncbi Cocaine detection in maternal and neonatal hair: implications to fetal toxicology
    Facundo Garcia-Bournissen
    Motherisk Program, Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, University of Toronto, Toronto, Canada
    Ther Drug Monit 29:71-6. 2007
    ..More research is needed to understand the mechanisms leading to placental defense against cocaine...
  77. ncbi Effects of a community-based drug use prevention program targeting licensed premises
    Johanna Gripenberg
    Department of Public Health Sciences, Karolinska Institute, Stockholm, Sweden
    Subst Use Misuse 42:1883-98. 2007
    ..Further research is necessary to explore the effectiveness of community-based drug use prevention programs targeting licensed premises...
  78. ncbi Broad-spectrum toxicological analysis of hair based on capillary zone electrophoresis-time-of-flight mass spectrometry
    Rossella Gottardo
    Department of Medicine and Public Health, Unit of Forensic Medicine, University of Verona, Verona, Italy
    J Chromatogr A 1159:190-7. 2007
    ..A single liquid-liquid extraction procedure was applied for all analytes, allowing the detection of a broad spectrum of basic drugs and their major metabolites...
  79. ncbi Prevalence of psychoactive substances in truck drivers in the Nord-Pas-de-Calais region (France)
    Laurence Labat
    Laboratoire Toxicologie et Génopathies, CHRU de Lille, Av Professeur J Leclercq, 59037 Lille Cedex, France
    Forensic Sci Int 174:90-4. 2008
    ..In conclusion, the authors think that it will be of a great interest to test urine of truck drivers for other classes of psychoactive drugs, using a liquid chromatography-mass spectrometry method...
  80. ncbi Driving under the influence in Greece: a 7-year survey (1998-2004)
    Stavroula A Papadodima
    Department of Forensic Medicine and Toxicology, School of Medicine, University of Athens, M Asias 75, Goudi, Athens 115 27, Greece
    Forensic Sci Int 174:157-60. 2008
    ..The above values were compared with those of a previous study concerning the period 1995-1997 and the reasons for the reduction of the number of alcohol-related traffic accidents during the last years are discussed...
  81. ncbi Patterns in drug use in the United Kingdom as revealed through analysis of hair in a large population sample
    Lolita Tsanaclis
    TrichoTech, No 1 Pentwyn Business Centre, Cardiff, United Kingdom
    Forensic Sci Int 170:121-8. 2007
    ..This means that the chances of identifying people on drugs in the workplace by testing hair samples are twice as likely than urine samples...
  82. ncbi Validation of a procedure for the gas chromatography-mass spectrometry analysis of cocaine and metabolites in pericardial fluid
    Maria Teresa Contreras
    Pharmacology Research Unit, Institut Municipal d Investigacio Medica IMIM, Barcelona, Spain
    J Anal Toxicol 31:75-80. 2007
    ..In this study, the procedure has been successfully applied to a number of forensic cases involving cocaine intoxication...
  83. ncbi Rapid quantification of buprenorphine-glucuronide and norbuprenorphine-glucuronide in human urine by LC-MS-MS
    S Hegstad
    Norwegian Institute of Public Health, Division of Forensic Toxicology and Drug Abuse, P O Box 4404 Nydalen, NO 0403 Oslo, Norway
    J Anal Toxicol 31:214-9. 2007
    ..The LC-MS-MS method proved to be robust and specific for the determination of BUP-G and NBUP-G in urine...
  84. ncbi Recent paramethoxymethamphetamine (PMMA) deaths in Taiwan
    Dong Liang Lin
    Institute of Forensic Medicine, Ministry of Justice, Taipei, Taiwan
    J Anal Toxicol 31:109-13. 2007
    ..The corresponding data for PMMA were 4.312, 4.806, and 1.208-15.824 microg/mL, respectively. Other drugs, such as MDA, MDMA, ketamine, norketamine, hydroxymidazolam, methamphetamine, and pentobarbital, were also found in these cases...
  85. ncbi Evaluation of the IDS One-Step ELISA kits for the detection of illicit drugs in hair
    Marie Laure Pujol
    Laboratoire ChemTox, Illkirch, France
    Forensic Sci Int 170:189-92. 2007
    ..This technology should find interest in workplace drug testing or driving license regranting, especially when many samples have to be tested with a high rate of negative samples, as ELISA is an easy and high-throughput method...
  86. ncbi Distribution of drugs of abuse within specific regions of the human brain
    T Stimpfl
    Department of Forensic Medicine, Medical University of Vienna, Vienna, Austria
    Forensic Sci Int 170:179-82. 2007
    ....
  87. ncbi Simultaneous quantification of opiates, amphetamines, cocaine and metabolites and diazepam and metabolite in a single hair sample using GC-MS
    Rosa Cordero
    Toxicology Unit, Imperial College London, St Dunstan s Road, London W6 8RP, United Kingdom
    J Chromatogr B Analyt Technol Biomed Life Sci 850:423-31. 2007
    ..The results of the analysis of hair taken from four patients attending a drug treatment clinic and six hair samples including head hair, pubic hair, axial hair and beard taken at post-mortem are presented...
  88. ncbi Differentiation between drug use and environmental contamination when testing for drugs in hair
    Lolita Tsanaclis
    TrichoTech, No 1 Pentwyn Business Centre, Cardiff CF23 7HB, United Kingdom
    Forensic Sci Int 176:19-22. 2008
    ....
  89. ncbi Hair analysis of anabolic steroids in connection with doping control-results from horse samples
    P Anielski
    Institute of Doping Analysis and Sports Biochemistry, Dresdner Strasse 12, D 01731 Kreischa, Germany
    J Mass Spectrom 43:1001-8. 2008
    ..Trimethylsilyl (TMS) and tert-butyl dimethylsilyl derivatives were detected by gas chromatography-high-resolution mass spectrometry (GC-HRMS) and gas chromatography-tandem mass spectrometry (GC-MS/MS)...
  90. ncbi Hair analysis for illicit drugs by using capillary zone electrophoresis-electrospray ionization-ion trap mass spectrometry
    Rossella Gottardo
    Department of Medicine and Public Health, Unit of Forensic Medicine, University of Verona, Verona, Italy
    J Chromatogr A 1159:185-9. 2007
    ..47% for areas in real samples, in both intra-day and day-to-day experiments. On these grounds, the described method can be proposed for rapid, selective and accurate toxicological hair analysis for both clinical and forensic purposes...
  91. ncbi Results of hair analyses for drugs of abuse and comparison with self-reports and urine tests
    F Musshoff
    Institute of Legal Medicine, Rheinische Friedrich Wilhelms University, Stiftsplatz 12, 53111 Bonn, Germany
    Forensic Sci Int 156:118-23. 2006
    ....
  92. ncbi Validation of an ELISA method for screening methadone in postmortem blood
    Matthew Juhascik
    UMass Memorial Forensic Toxicology Laboratory, Worcester, Massachusetts 01605, USA
    J Anal Toxicol 30:617-20. 2006
    ..The Venture Labs methadone assay demonstrated a sensitivity of 96.7%+/-2.3% and a specificity of 98.3%+/-1.7% relative to the GC-MS method...
  93. ncbi [Drug addiction in the medico-legal certification of the Department of Forensic Medicine of Medical University of Gdańsk in the years 1996-2005]
    Katarzyna Galer-Tatarowicz
    Z Katedry i Zakfadu Medycyny Sedowej Akademii Medycznej w Gdarisku Kierownik dr hab med Z Jankowski
    Arch Med Sadowej Kryminol 57:277-84. 2007
    ..The presence of both ethanol and drugs was detected and confirmed mainly in post-mortem biological materials...
  94. ncbi Roadside oral fluid testing: comparison of the results of drugwipe 5 and drugwipe benzodiazepines on-site tests with laboratory confirmation results of oral fluid and whole blood
    Anna Pehrsson
    National Public Health Institute, Drug Research Unit, Mannerheimintie 166, FI 00300 Helsinki, Finland
    Forensic Sci Int 175:140-8. 2008
    ....
  95. ncbi Biological, clinical, and forensic analysis using comprehensive two-dimensional gas chromatography
    Nicholas H Snow
    Department of Chemistry and Biochemistry, Seton Hall University, South Orange, New Jersey, USA
    Adv Chromatogr 45:215-43. 2007
  96. ncbi Detection of cocaine analytes and opiates in nails from postmortem cases
    David A Engelhart
    Office of the Cuyahoga County Coroner, Cleveland, Ohio 44106, USA
    J Anal Toxicol 26:489-92. 2002
    ..These results demonstrate the usefulness of nails as postmortem specimens in detecting drugs of abuse...
  97. ncbi Value of hair analysis in postmortem toxicology
    Pascal Kintz
    Institut de Medecine Legale, 11, rue Humann, F 67000 Strasbourg, France
    Forensic Sci Int 142:127-34. 2004
    ..Moreover, the window of drug detection is dramatically extended to weeks, months or even years. The aim of this review is to document the current status of hair analysis in postmortem toxicology...
  98. ncbi On-site testing of illicit drugs: the use of the drug-testing device "Toxiquick"
    T Biermann
    Department of Forensic Medicine, University Erlangen Nuremberg, Universitaetsstrasse 22, D 91054 Erlangen, Germany
    Forensic Sci Int 143:21-5. 2004
    ..Except for cannabinoids, the number of false negative results was relatively small, whereas false positive results ranged between 32.2% for opiates and 10.7% for benzoylecgonine...
  99. ncbi Evaluation of the One-Step ELISA kit for the detection of buprenorphine in urine, blood, and hair specimens
    V Cirimele
    Laboratoire de Toxicologie, Institut de Medecine Legale, 11 rue Humann, F 67085 Strasbourg, France
    Forensic Sci Int 143:153-6. 2004
    ..3-15.6 ng/mL), did not cause a false negative response by the immunoassay...
  100. ncbi Development of a screening method for the most commonly abused anticholinergic drugs in Jordan; trihexyphenidyl, procyclidine and biperiden
    Kamal A Hadidi
    Forensic Medicine and Toxicology Division, Faculty of Medicine, University of Jordan, Amman 11942, Jordan
    Leg Med (Tokyo) 6:233-41. 2004
    ..The method will offer the clinicians and the legal authority the right diagnosis regarding the anticholinergic involved in any case of abuse with less than 1 h per sample (plasma or urine) from the time of receiving...

Research Grants71

  1. PARAMETRIC STUDIES OF DRUG ABUSE ABSTINENCE INCENTIVES
    Maxine Stitzer; Fiscal Year: 2004
    ..The information to be obtained will further advance our understanding of incentive therapies and how these can be tailored for improved efficacy in specific populations. ..
  2. Experimental Analysis of Smoking Relapse
    Maxine Stitzer; Fiscal Year: 2006
    ..Further, valuable information will be obtained about the potentially powerful effects of smoking after brief periods of abstinence (lapse) using these new models. ..
  3. Methadone maintenance and HIV risk in Ukraine
    George Woody; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  4. Prescription Psychotherapeutic Drug Use Among Older Adults
    Yu Ping Chang; Fiscal Year: 2011
    ..Clinicians need to routinely screen medication-taking behaviors among older adults who are prescribed psychotherapeutic drug in order to practice prevention and early intervention. ..
  5. Computerized alcohol screening for children and adolescents (cASCA) in primary ca
    John R Knight; Fiscal Year: 2013
    ..g., those with/without friends who drink); and explore the possible effects of the cASCA system on drinking at 3-, 6-, 9-, and 12-month follow-ups. ..
  6. Enhanced brief Intervention for linking opiate abusing EMS patients to treatment
    Amy Knowlton; Fiscal Year: 2013
    ..The academic-interagency collaboration builds on study team members'decades of successful relevant research with the study population. . ..
  7. Interactive Simulation to Train Prescription Drug Abuse Screening
    Dale Olsen; Fiscal Year: 2009
    ..Screening patients for prescription drug abuse in primary care settings may help identify abuse sooner and lead to life-changing interventions which could reduce the negative impact of prescription and other drug abuse and addiction. ..
  8. PARTNER VIOLENCE DURING TRANSITIONS IN PREGNANCY
    Sandra Martin; Fiscal Year: 2001
    ..These newly developed procedures are appropriate for the analysis of longitudinal data (both continuous and categorical outcomes) and will allow for the inclusion of potentially important time-dependent covariates in the study models. ..
  9. IDENTIFYING SUBSTANCE ABUSE DISORDERS IN MENTALLY ILL
    Stanley Rosenberg; Fiscal Year: 1999
    ....
  10. WEB-BASED DRUG-FREE WORKPLACE DEVELOPMENT
    J Walsh; Fiscal Year: 2004
    ..Furthermore, we intend to develop a mechanism to evaluate the use of the website and utilize the information to demonstrate the feasibility and commercial viability of the concept. ..
  11. Six Programs for the Future of Alcohol Safety
    Robert Voas; Fiscal Year: 2007
    ..Voas to become involved in a broader range of programs than if he otherwise were limited by taking on the full management of individual R01 projects. For this effort we are requesting 5 years of support for 75% of Dr. Voas' time. ..
  12. Campuses selling alcohol--Profit of Problem?
    Robert Voas; Fiscal Year: 2005
    ....
  13. Lowering the drinking age: The New Zealand example
    Robert Voas; Fiscal Year: 2005
    ..abstract_text> ..
  14. EVALUATION OF EFFORTS TO REDUCE BORDER BINGE DRINKING
    Robert Voas; Fiscal Year: 2002
    ..El Paso/Juarez, a border town with a similar border-binge drinking problem will, serve as a comparison site. ..
  15. ENVIRONMENTAL PREVENTION OF COLLEGE ALCOHOL PROBLEMS
    Robert Voas; Fiscal Year: 2003
    ..abstract_text> ..
  16. Drivers with Alcohol Use Disorders: At high risk for crashes?
    Robert B Voas; Fiscal Year: 2010
    ..It will determine the prevalence of drivers with alcohol use disorders in traffic crashes and provide information to policymakers concerned with treatment and prevention programs. ..
  17. Campuses selling alcohol--Profit of Problem?
    Robert Voas; Fiscal Year: 2001
    ....
  18. ENHANCING ALCOHOL INTERLOCK EFFECTS ON 1ST DUI OFFENDERS
    Robert Voas; Fiscal Year: 2004
    ..This research builds on experience gained in a 5-year RO1-funded program in Alberta, Canada. ..
  19. Improving Care Continuity in Drug Abuse Treatment
    Maxine L Stitzer; Fiscal Year: 2010
    ..Overall, the project will provide valuable new data that can be used by policy makers to select treatment transition options that will maximize continuity of care within a drug abuse treatment services delivery system. ..
  20. RECOVERY HOUSING AND DRUG ABUSE TREATMENT OUTCOMES
    Maxine Stitzer; Fiscal Year: 2005
    ..Thus, the project has both scientific value for services research and practical value for clinical application. ..
  21. TREATMENT FOR DUALLY DEPENDENT METHADONE PATIENTS
    Nancy Petry; Fiscal Year: 2002
    ....
  22. SOCIETY FOR RESEARCH ON NICOTINE AND TOBACCO ANN MEETING
    Maxine Stitzer; Fiscal Year: 2002
    ..Partial support of this meeting by NIDA would further highlight the agency's commitment to the importance of nicotine and tobacco research. ..
  23. Employment-Based Addiction Pharmacotherapy
    Kenneth Silverman; Fiscal Year: 2009
    ..abstract_text> ..
  24. AFTERCARE FOR SUBSTANCE ABUSERS
    James McKay; Fiscal Year: 2008
    ..The cost-effectiveness and benefit cost of each of the enhanced interventions will also be determined, through a collaboration with Dr. Michael French. [unreadable] [unreadable] [unreadable] [unreadable]..
  25. Contingency Management: Duration Effects
    John Roll; Fiscal Year: 2007
    ..This is timely, given the burgeoning rates of methamphetamine abuse being reported. ..
  26. Protective Influence of Residential Learning Communities
    SEAN MCCABE; Fiscal Year: 2006
    ..At each measurement point, participants will complete a set of measures that assess substance use behaviors and constructs addressed by RLCs. ..
  27. Effectiveness of extended treatments for drug dependence
    James R McKay; Fiscal Year: 2010
    ..Other analyses will test mediation hypotheses, examine potential moderator effects, and test the impact of disease management on HIV risk behaviors. ..
  28. Epidemiology of Prescription Drug Abuse in the United States
    SEAN MCCABE; Fiscal Year: 2007
    ..It will help identify risk factors for substance abuse. Most importantly, the findings will provide guidance for the prevention, assessment, and treatment of prescription drug abuse. [unreadable] [unreadable]..
  29. A REINFORCEMENT-BASED THERAPEUTIC WORKPLACE
    Kenneth Silverman; Fiscal Year: 2006
    ..This research could provide firm scientific foundation for the dissemination of Therapeutic Workplace businesses in the long-term treatment of cocaine addiction and unemployment. ..
  30. Alcohol in Aviation and Motor Carriers
    Guohua Li; Fiscal Year: 2010
    ..Findings from theproposed research couldprovide much-neededscientific evidence for informing important policy decisions relevant to transportation safety andprotection of the traveling public. ..
  31. Counseling for Primary Care Office-Based Buprenorphine
    David Fiellin; Fiscal Year: 2009
    ..The results of this study will help define the role of professional evidence-based drug counseling in expanding access to treatment with Bup. ..
  32. Effectiveness of Extended Telephone Monitoring
    James McKay; Fiscal Year: 2007
    ..Economic analyses will determine the cost-effectiveness and benefit-cost of TMC and TMF relative to TAU, andto ach other. ..
  33. Treatment System Impact & Outcomes of Proposition 36
    Yih Ing Hser; Fiscal Year: 2006
    ..The project will produce recommendations to improve treatment strategies and inform future policy and practice at the national, state, and local levels. ..
  34. Reducing Cocaine/Heroin Abuse with SR-Amphetamine and Buprenorphine
    Mark Greenwald; Fiscal Year: 2009
    ..The innovative aims, rigorous methods and clinical/public health significance of this project (i.e. whether SR-AMP has potential efficacy for reducing cocaine use) is highly concordant with this RFA. ..
  35. AFTERCARE FOR COCAINE PATIENTS--EFFECTIVENESS AND COSTS
    James McKay; Fiscal Year: 2001
    ..However, it is expected that MIN aftercare will be cost-effective for low problem severity ("good prognosis") patients, whereas IND aftercare will be cost-effective for high problem severity ("poor prognosis") patients. ..
  36. A THERAPEUTIC WORKPLACE FOR HOMELESS ALCOHOLICS
    Kenneth Silverman; Fiscal Year: 2004
    ..abstract_text> ..
  37. Effectiveness and Costs of Enhanced Cocaine Treatments
    James McKay; Fiscal Year: 2005
    ..voucher reinforcement. Additional analyses will identify predictors of response to the TAU+V and TAU+S conditions, and test predictions regarding possible mechanisms of action. ..
  38. Readiness for Implementation of Research to Practice
    Yih Ing Hser; Fiscal Year: 2004
    ..abstract_text> ..
  39. Sexual Orientation, Substance Use and Mental Health
    SEAN MCCABE; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  40. ADOLESCENT SMOKING CESSATION
    John Roll; Fiscal Year: 2002
    ..Secondarily, the proposed study will provide valuable information on the nicotine withdrawal syndrome in adolescents, a topic about which relatively little is known. ..
  41. THERAPEUTIC WORKPLACE TO PREVENT HIV TRANSMISSION
    Kenneth Silverman; Fiscal Year: 2003
    ..abstract_text> ..
  42. Nonmedical Prescription Drug Use among College Students
    SEAN MCCABE; Fiscal Year: 2005
    ..Findings from this research will have important implications for the understanding of the epidemiology, prevention and treatment of prescription drug abuse. ..
  43. A 12 YEAR FOLLOW UP OF A COCAINE DEPENDENT SAMPLE
    Yih Ing Hser; Fiscal Year: 2003
    ..abstract_text> ..
  44. A Long-term Follow-up Study of Drug-Dependent Mothers and Children
    Yih Ing Hser; Fiscal Year: 2010
    ..The study will also lay the foundation for future in-depth investigation of the children of these mothers with histories of substance abuse. ..
  45. Human Methamphetamine Use: A Model
    John Roll; Fiscal Year: 2002
    ..Studies using laboratory models of human drug use can inform subsequent clinical trials and help to focus them on those variables which are likely to be important. ..
  46. Human Behavorial Pharmacology of GHB
    John Roll; Fiscal Year: 2002
    ....
  47. DRUG ABUSE: EPIDEMIOLOGY, TREATMENT PROCESS, & OUTCOMES
    Yih Ing Hser; Fiscal Year: 2003
    ..The applicant also expects to grow professionally as Associate Director of the UCLA Drug Abuse Research Center. ..
  48. Reducing HIV/AIDS and Drug Abuse: Linking Compulsory Rehabilitation to Methadone
    Yih Ing Hser; Fiscal Year: 2008
    ..If proven effective, the program can be widely applied in China and in other parts of the world to reduce heroin use and related HIV risk behaviors. [unreadable] [unreadable] [unreadable]..
  49. Behavior Change: Reinforcemnt Schedule Effects
    John Roll; Fiscal Year: 2006
    ..Based on the widespread success of contingency management across many different applications, we believe that the results of the proposed study will have 9enerality beyond the field of substance abuse treatment. ..
  50. Human Laboratory Model of Cocaine Treatment: Behavioral Economic Analysis
    Mark K Greenwald; Fiscal Year: 2010
    ....
  51. Topiramate for alcohol and cocaine dependence
    Kyle Kampman; Fiscal Year: 2008
    ..abstract_text> ..
  52. TRANSFERRING DRUG ABUSE TREATMENT AND ASSESSMENT RESOURC
    D Simpson; Fiscal Year: 2008
    ..abstract_text> ..
  53. Prescription Drug Abuse Among College Students
    SEAN MCCABE; Fiscal Year: 2005
    ....
  54. Alcohol and Injury: New Knowledge from ER Studies
    Cheryl Cherpitel; Fiscal Year: 2005
    ....
  55. Effective Treatment for Prescription Opioid Abuse
    STACEY SIGMON; Fiscal Year: 2009
    ..Development of efficacious treatments for this emerging population will help to reduce the vast economic and societal costs associated with prescription opioid abuse. ..
  56. Trazodone for Sleep Disturbance - Early Alcohol Recovery
    Peter Friedmann; Fiscal Year: 2004
    ..Our extensive contacts with community agencies and substance abuse treatment facilities should enhance follow-up rates. ..
  57. Naltrexone for Bipolar Disorder and Alcohol Dependence
    E Sherwood Brown; Fiscal Year: 2006
    ..Alcohol use is the primary outcome, and alcohol craving is the secondary outcome. Manic and depressive symptom severity and the relationship between changes in alcohol use and changes in mood will be expIored. ..
  58. Consequences of Prenatal Cocaine Exposure in Adolescence
    Virginia Delaney Black; Fiscal Year: 2006
    ..The proposed research will provide data critical to understanding the impact of prenatal cocaine exposure in adolescence, and to shape future studies of problem behaviors in late adolescence and early adulthood. ..
  59. Diffusion of Drug Prevention Curricula Nationwide
    Christopher Ringwalt; Fiscal Year: 2007
    ..abstract_text> ..
  60. Promoting Fidelity Using Remote and Onsite Support
    Christopher Ringwalt; Fiscal Year: 2006
    ..Study results will inform the prevention field concerning the potential for personalized coaching and technical assistance to promote curriculum fidelity and affect key student-level mediating variables. ..
  61. Fetal and Infant Neurobehavior in Opiate Dependent Women
    Lauren Jansson; Fiscal Year: 2009
    ..Information gained from this proposal has the potential to significantly impact the way in which we treat the difficult and high-risk population of opiate dependent pregnant women. ..
  62. CHARACTERIZING PSYCHOACTIVE EFFECTS OF INHALANTS
    James Zacny; Fiscal Year: 2004
    ..In short, in our two proposed series of studies, we are developing a human laboratory model of inhalant abuse by studying potential determinants of abuse liability of inhalants (volatile and gaseous) in healthy volunteers. ..
  63. METHADONE, BUPRENORPHINE AND FETAL DEVELOPMENT
    Lauren Jansson; Fiscal Year: 2004
    ..Upon completing the 5-year funding period, Dr. Jansson plans to have written an RO1 grant application to pursue research ideas identified during KO8 funding. ..
  64. Abuse-Related Effects of Opioids and Adjuvant Drug Used by Chronic Pain Patients
    James P Zacny; Fiscal Year: 2010
    ..g., muscle relaxant B) would be the preferred drug to prescribe when treating chronic nonmalignant pain patients. ..
  65. "Engaging Moms." An Intervention for Family Drug Court
    GAYLE DAKOF; Fiscal Year: 2006
    ..abstract_text> ..
  66. Pathways From Subtypes of Aggression to Substance Use
    Paula Fite; Fiscal Year: 2007
    ....
  67. Behavior Therapy Development of Group CM in Methadone Tx
    Kimberly Kirby; Fiscal Year: 2008
    ..e., number of behaviors targeted, frequency of urine testing). While developing this Group CM intervention will not by itself result in improved dissemination of CM, it is a critical first step in this direction. ..