pulsatile flow

Summary

Summary: Rhythmic, intermittent propagation of a fluid through a BLOOD VESSEL or piping system, in contrast to constant, smooth propagation, which produces laminar flow.

Top Publications

  1. ncbi Plasma fatty acid composition as a predictor of arterial stiffness and mortality
    Simon G Anderson
    Division of Cardiovascular and Endocrine Sciences, University of Manchester Medical School, 46 Grafton St, Manchester, M13 9NT United Kingdom
    Hypertension 53:839-45. 2009
  2. ncbi Measurement of pulse wave velocity using pulse wave Doppler ultrasound: comparison with arterial tonometry
    Benyu Jiang
    King s College of London, Cardiovascular Division, Thomas s Hospital, London, UK
    Ultrasound Med Biol 34:509-12. 2008
  3. ncbi Aortic pulse wave velocity predicts cardiovascular mortality in subjects >70 years of age
    S Meaume
    Geriatrics Department of Charles-Foix Hospital, Limeil-Brevannes, France
    Arterioscler Thromb Vasc Biol 21:2046-50. 2001
  4. ncbi Determination of wave speed and wave separation in the arteries
    A W Khir
    Physiological Flow Studies Group, Department of Biological and Medical Systems, Imperial College of Science, Technology and Medicine, London SW7 2AZ, UK
    J Biomech 34:1145-55. 2001
  5. ncbi Age-associated elongation of the ascending aorta in adults
    Jun Sugawara
    Department of Kinesiology and Health Education, University of Texas at Austin, Austin, Texas 78712 1204, USA
    JACC Cardiovasc Imaging 1:739-48. 2008
  6. ncbi Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study
    Francesco U S Mattace-Raso
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Circulation 113:657-63. 2006
  7. ncbi Prognostic value of aortic pulse wave velocity as index of arterial stiffness in the general population
    Tine Willum-Hansen
    Research Center for Prevention and Health, Copenhagen, Denmark
    Circulation 113:664-70. 2006
  8. ncbi Impact of aortic stiffness attenuation on survival of patients in end-stage renal failure
    A P Guerin
    , , , , , Paris, France
    Circulation 103:987-92. 2001
  9. ncbi Stiffness of capacitive and conduit arteries: prognostic significance for end-stage renal disease patients
    Bruno Pannier
    Service d Hemodialyse, Hôpital F H Manhès, Paris, France
    Hypertension 45:592-6. 2005
  10. ncbi Influences of age and gender on results of noninvasive brachial-ankle pulse wave velocity measurement--a survey of 12517 subjects
    Hirofumi Tomiyama
    The Second Department of Internal Medicine, Tokyo Medical University, 6 7 1 Nishi shinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Atherosclerosis 166:303-9. 2003

Research Grants

Detail Information

Publications308 found, 100 shown here

  1. ncbi Plasma fatty acid composition as a predictor of arterial stiffness and mortality
    Simon G Anderson
    Division of Cardiovascular and Endocrine Sciences, University of Manchester Medical School, 46 Grafton St, Manchester, M13 9NT United Kingdom
    Hypertension 53:839-45. 2009
    ..The results are consistent with an effect of dietary sources of n-3 long-chain polyunsaturates influencing arterial stiffness and mortality...
  2. ncbi Measurement of pulse wave velocity using pulse wave Doppler ultrasound: comparison with arterial tonometry
    Benyu Jiang
    King s College of London, Cardiovascular Division, Thomas s Hospital, London, UK
    Ultrasound Med Biol 34:509-12. 2008
    ..8%. These results suggest a commercial ultrasound scanner can be used to measure PWV, giving results that are reproducible and closely correlated with those obtained by arterial tonometry. (E-mail: ben_yu.jiang@kcl.ac.uk)...
  3. ncbi Aortic pulse wave velocity predicts cardiovascular mortality in subjects >70 years of age
    S Meaume
    Geriatrics Department of Charles-Foix Hospital, Limeil-Brevannes, France
    Arterioscler Thromb Vasc Biol 21:2046-50. 2001
    ..In subjects 70 to 100 years old, aortic PWV is a strong, independent predictor of cardiovascular death, whereas systolic or pulse pressure was not. This prospective result will need to be confirmed in an intervention trial...
  4. ncbi Determination of wave speed and wave separation in the arteries
    A W Khir
    Physiological Flow Studies Group, Department of Biological and Medical Systems, Imperial College of Science, Technology and Medicine, London SW7 2AZ, UK
    J Biomech 34:1145-55. 2001
    ..In cases where reflected waves are prominent, this separation of waves can help clarify the pattern of waves in the arteries throughout the cardiac cycle...
  5. ncbi Age-associated elongation of the ascending aorta in adults
    Jun Sugawara
    Department of Kinesiology and Health Education, University of Texas at Austin, Austin, Texas 78712 1204, USA
    JACC Cardiovasc Imaging 1:739-48. 2008
    ..To determine whether human aorta lengthens with aging and to evaluate the impact of the hypothesized aortic elongation on pulse wave velocity (PWV) measurements...
  6. ncbi Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study
    Francesco U S Mattace-Raso
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Circulation 113:657-63. 2006
    ..We evaluated whether arterial stiffness is a predictor of coronary heart disease and stroke in a population-based study among apparently healthy subjects...
  7. ncbi Prognostic value of aortic pulse wave velocity as index of arterial stiffness in the general population
    Tine Willum-Hansen
    Research Center for Prevention and Health, Copenhagen, Denmark
    Circulation 113:664-70. 2006
    ..Few population studies addressed the prognostic significance of aortic pulse wave velocity (APWV) above and beyond other cardiovascular risk factors...
  8. ncbi Impact of aortic stiffness attenuation on survival of patients in end-stage renal failure
    A P Guerin
    , , , , , Paris, France
    Circulation 103:987-92. 2001
    ....
  9. ncbi Stiffness of capacitive and conduit arteries: prognostic significance for end-stage renal disease patients
    Bruno Pannier
    Service d Hemodialyse, Hôpital F H Manhès, Paris, France
    Hypertension 45:592-6. 2005
    ....
  10. ncbi Influences of age and gender on results of noninvasive brachial-ankle pulse wave velocity measurement--a survey of 12517 subjects
    Hirofumi Tomiyama
    The Second Department of Internal Medicine, Tokyo Medical University, 6 7 1 Nishi shinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Atherosclerosis 166:303-9. 2003
    ..Thus, aging influences baPWV, and its effect is more prominent in female. Menopause seems to be the crucial phenomenon to explain the augmented increase in arterial stiffness with aging in females...
  11. ncbi Dissociation of aortic pulse wave velocity with risk factors for cardiovascular disease other than hypertension: a systematic review
    Marina Cecelja
    King s College London British Heart Foundation Centre, Cardiovascular Division, Department of Clinical Pharmacology, St Thomas Hospital, London, United Kingdom
    Hypertension 54:1328-36. 2009
    ..The prognostic value of cfPWV may relate to a process of arterial ageing unrelated to classic risk factors other than hypertension...
  12. ncbi Brachial-ankle pulse wave velocity as a marker of atherosclerotic vascular damage and cardiovascular risk
    Akira Yamashina
    Second Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan
    Hypertens Res 26:615-22. 2003
    ..While the discriminating powers are not sufficiently high, a cutoff value of 14.0 m/s serves to screen subjects, especially in middle-aged ones, of either gender...
  13. ncbi Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults
    Kim Sutton-Tyrrell
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Circulation 111:3384-90. 2005
    ..The objective of this investigation was to determine whether aPWV is associated with total and cardiovascular (CV) mortality and CV events in a community-dwelling sample of older adults...
  14. ncbi Aortic pulse wave velocity index and mortality in end-stage renal disease
    Jacques Blacher
    Service de Medecine Interne, Hopital Broussais, AP HP, Paris, France
    Kidney Int 63:1852-60. 2003
    ..Nevertheless, because age, blood pressure, heart rate, and gender are strong determinants of both arterial stiffness and mortality, the individual relevance of PWV measurements remains controversial...
  15. ncbi The influence of out-of-plane geometry on pulsatile flow within a distal end-to-side anastomosis
    Y Papaharilaou
    Biomedical Flow Group, Aeronautics Department, Imperial College of Science, Technology and Medicine, Prince Consort Road, London SW7 2BY, UK
    J Biomech 35:1225-39. 2002
    ....
  16. ncbi Unsteady and three-dimensional simulation of blood flow in the human aortic arch
    N Shahcheraghi
    Department of Mechanical and Aeronautical Engineering, Institute for Theoretical Dynamics, University of California, Davis 95616, USA
    J Biomech Eng 124:378-87. 2002
    ..Comparison of our numerical results with the localization of early atherosclerotic lesions broadly suggests preferential development of these lesions in regions of extrema (either maxima or minima) in wall shear stress and pressure...
  17. pmc Influence of intracranial aneurysm-to-parent vessel size ratio on hemodynamics and implication for rupture: results from a virtual experimental study
    Markus Tremmel
    Department of Neurosurgery, University at Buffalo, State University of New York, Buffalo, New York, USA
    Neurosurgery 64:622-30; discussion 630-1. 2009
    ..As hemodynamics have been implicated in both IA development and rupture, we examine how varying SR influences intra-aneurysmal hemodynamics...
  18. pmc Arterial stiffness in mild-to-moderate CKD
    Ashish Upadhyay
    Renal Section, Boston Medical Center and Boston University School of Medicine, Boston, Massachusetts, USA
    J Am Soc Nephrol 20:2044-53. 2009
    ..Baseline arterial measures did not associate with incident CKD or incident microalbuminuria. In summary, arterial stiffness correlates with albuminuria but not with mild-to-moderate CKD...
  19. pmc High pulsatility flow induces adhesion molecule and cytokine mRNA expression in distal pulmonary artery endothelial cells
    Min Li
    Department of Pediatrics Cardiology, The Children s Hospital, University of Colorado at Denver, Aurora, CO 80045, USA
    Ann Biomed Eng 37:1082-92. 2009
    ..Thus, this study was designed to examine the responses of the microvascular pulmonary endothelium to changes in flow pulsatility...
  20. ncbi Finite element modeling of three-dimensional pulsatile flow in the abdominal aorta: relevance to atherosclerosis
    C A Taylor
    Department of Surgery, Stanford University, CA, USA
    Ann Biomed Eng 26:975-87. 1998
    ..Monogr. Atheroscler. 15:13-19, 1990). This numerical investigation provides detailed quantitative data on hemodynamic conditions in the abdominal aorta heretofore lacking in the study of the localization of atherosclerotic disease...
  21. ncbi Ethnic differences in aortic pulse wave velocity occur in the descending aorta and may be related to vitamin D
    Mohammad Reza Rezai
    Diabetes, Nutrition and Cardiovascular Medicine Research Group, Franklin Wilkins Building level 4, King s College University of London and King s Health Partners, 150 Stamford Street, London SE1 9NH, UK
    Hypertension 58:247-53. 2011
    ....
  22. ncbi Estimation of central pressure augmentation using automated radial artery tonometry
    Vojtech Melenovsky
    Department of Cardiology, IKEM, Prague, Czech Republic
    J Hypertens 25:1403-9. 2007
    ..However, carotid tonometry is technically challenging and difficult to standardize in practice. We tested whether automated radial pressure analysis provides a viable alternative...
  23. pmc Reduced ascending aortic strain and distensibility: earliest manifestations of vascular aging in humans
    Alban Redheuil
    Division of Cardiology, Johns Hopkins University, Baltimore, MD 21287, USA
    Hypertension 55:319-26. 2010
    ..In particular, compared with other measures of aortic function, the best markers of subclinical large artery stiffening, were AA distensibility in younger and aortic arch pulse wave velocity in older individuals...
  24. ncbi Reproducibility of derived central arterial waveforms in patients with chronic renal failure
    M Tessa Savage
    Department of Renal Medicine, The Richard Bright Renal Unit, Southmead Hospital, Westbury on Trym, Bristol BS10 5NB, UK
    Clin Sci (Lond) 103:59-65. 2002
    ....
  25. ncbi A general model for the origin of allometric scaling laws in biology
    G B West
    Theoretical Division, T 8, Mail Stop B285, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Science 276:122-6. 1997
    ..More generally, the model predicts structural and functional properties of vertebrate cardiovascular and respiratory systems, plant vascular systems, insect tracheal tubes, and other distribution networks...
  26. ncbi Hypertensive disorders in pregnancy: screening by biophysical and biochemical markers at 11-13 weeks
    L C Y Poon
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
    Ultrasound Obstet Gynecol 35:662-70. 2010
    ..To examine the performance of screening for pre-eclampsia (PE) and gestational hypertension (GH) by a combination of maternal factors and various biophysical and biochemical markers at 11-13 weeks' gestation...
  27. ncbi Comparison of aortic pulse wave velocity measured by three techniques: Complior, SphygmoCor and Arteriograph
    Marek W Rajzer
    1st Department of Cardiology and Hypertension, Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland
    J Hypertens 26:2001-7. 2008
    ..The aim of the study was to compare aortic pulse wave velocity measurements using Complior, SphygmoCor, and Arteriograph devices, and to assess the effect of pulse wave transit time and traveled distance on pulse wave velocity values...
  28. ncbi Heart rate: an important confounder of pulse wave velocity assessment
    Pierre Lantelme
    Service de cardiologie, Hopital de la Croix Rousse, Hospices Civils de Lyon, Faculté de Médecine Lyon Nord, Lyon, France
    Hypertension 39:1083-7. 2002
    ..This raises methodological concern about the measurement of this parameter. Standardizing PWV for HR level seems mandatory if one wants to interpret PWV changes in clinical trials or in the follow-up of patients...
  29. ncbi Albuminuria is strongly associated with arterial stiffness, especially in diabetic or hypertensive subjects--a population-based study (Taichung Community Health Study, TCHS)
    Chiu Shong Liu
    Department of Family Medicine, China Medical University Hospital, and Department of Family Medicine, China Medical University, Taichung, Taiwan
    Atherosclerosis 211:315-21. 2010
    ..Limited information is available for the association between albuminuria and arterial stiffness in Chinese. We aimed to assess the association between albuminuria and arterial stiffness in a middle-aged population-based study...
  30. ncbi Validation and reproducibility of aortic pulse wave velocity as assessed with velocity-encoded MRI
    Heynric B Grotenhuis
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    J Magn Reson Imaging 30:521-6. 2009
    ..To validate magnetic resonance imaging (MRI) assessment of aortic pulse wave velocity (PWV(MRI)) with PWV determined from invasive intra-aortic pressure measurements (PWV(INV)) and to test the reproducibility of the measurement by MRI...
  31. ncbi Heart rate dependency of pulse pressure amplification and arterial stiffness
    Ian B Wilkinson
    Clinical Pharmacology Unit, University of Edinburgh, Western General Hospital, United Kingdom
    Am J Hypertens 15:24-30. 2002
    ..The aim of the present study was to assess the effect of acute changes in heart rate on arterial stiffness and on peripheral and central pulse pressure in healthy subjects...
  32. ncbi Noninvasive determination of carotid-femoral pulse wave velocity depends critically on assessment of travel distance: a comparison with invasive measurement
    Thomas Weber
    Cardiology Department, Klinikum Wels Grieskirchen, Grieskirchnerstrasse 42, Wels 4600, Austria
    J Hypertens 27:1624-30. 2009
    ..The aim of our study was to compare cfPWV, calculated with commonly used noninvasive methods for travel distance assessment, against aortic PWV measured invasively...
  33. ncbi Multidetector-row computed tomography imaging characteristics of mechanical prosthetic valves
    Petr Symersky
    Department of Cardiothoracic Surgery, Isala Klinieken Zwolle, The Netherlands
    J Heart Valve Dis 20:216-22. 2011
    ..A pulsatile in vitro model was developed to study the MDCT imaging characteristics of mechanical heart valves (MHVs)...
  34. ncbi Brachial-ankle pulse wave velocity as an index of central arterial stiffness
    Shoko Tsuchikura
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    J Atheroscler Thromb 17:658-65. 2010
    ..An automated device for brachial-ankle (ba) PWV is available, although information is limited whether baPWV reflects the stiffness of central or peripheral arteries. We therefore addressed this question in the present study...
  35. ncbi Wall shear stress--an important determinant of endothelial cell function and structure--in the arterial system in vivo. Discrepancies with theory
    Robert S Reneman
    Department of Physiology, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands
    J Vasc Res 43:251-69. 2006
    ..Applications of wall shear stress as in flow-mediated arterial dilation, clinically in use to assess endothelial cell (dys)function, are also addressed. This review starts with some background considerations and some theoretical aspects...
  36. ncbi Transcranial Doppler pulsatility indices as a measure of diffuse small-vessel disease
    C S Kidwell
    Stroke Center, Department of Neurology, 710 Westwood Plaza, UCLA Medical Center, Los Angeles, CA 90095, USA
    J Neuroimaging 11:229-35. 2001
    ..Elevation in pulsatility indices (PIs) as measured by transcranial Doppler (TCD) have been postulated to reflect downstream increased vascular resistance caused by small-vessel ischemic disease...
  37. ncbi Vascular compliance in blood pressure
    Leopoldo Raij
    Division of Nephrology and Hypertension, University of Miami, Miami, Florida 33125 1624, USA
    Curr Opin Nephrol Hypertens 20:457-64. 2011
    ..Vascular stiffening is a hallmark of the aging process. Improvements in the methods used to measure central stiffness, particularly applanation tonometry, and their use as therapeutic targets have generated great interest...
  38. ncbi Simultaneous aortic and coronary assessment in abdominal aortic aneurysm patients by thoraco-abdominal 64-detector-row CT angiography: estimate of the impact on preoperative management: a pilot study
    R P J Budde
    Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Vasc Endovasc Surg 40:196-201. 2010
    ..To estimate the influence of information on the coronary arteries obtained from routine thoraco-abdominal CT angiography (CTA) on pre-operative clinical management in abdominal aortic aneurysm (AAA) patients...
  39. ncbi Magnetic resonance assessment of aortic pulse wave velocity, aortic distensibility, and cardiac function in uncomplicated type 2 diabetes mellitus
    Rutger W van der Meer
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    J Cardiovasc Magn Reson 9:645-51. 2007
    ..Furthermore, CMR is a reliable method for assessing left ventricular (LV) function. The purpose of this study was to assess LV function, PWV, and aortic distensibility in patients with DM2 using MR...
  40. ncbi Numerical simulation of blood pulsatile flow in a stenosed carotid artery using different rheological models
    A Razavi
    Department of Mechanical Engineering, Isfahan University of Technology, Isfahan 8415683111, Iran
    J Biomech 44:2021-30. 2011
    ..Increasing stenosis intensity causes flow patterns more disturbed downstream of the stenosis and WSS appear to develop remarkably at the stenosis throat...
  41. ncbi Hemodynamic factors at the distal end-to-side anastomosis of a bypass graft with different POS:DOS flow ratios
    X M Li
    Department of Biomedical Engineering, The University of Akron, OH 44325-0302, USA
    J Biomech Eng 123:270-6. 2001
    A pulsatile flow in vitro model of the distal end-to-side anastomosis of an arterial bypass graft was used to examine the effects that different flow ratios between the proximal outlet segment (POS) and the distal outlet segment (DOS) ..
  42. pmc Twelve hour reproducibility of choroidal blood flow parameters in healthy subjects
    E Polska
    Department of Clinical Pharmacology, University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Br J Ophthalmol 88:533-7. 2004
    ..Aims/background: To investigate the reproducibility and potential diurnal variation of choroidal blood flow parameters in healthy subjects over a period of 12 hours...
  43. ncbi Flow simulation studies in coronary arteries--impact of side-branches
    Ernst Wellnhofer
    Department of Internal Medicine Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany
    Atherosclerosis 213:475-81. 2010
    ..Wall shear stress (WSS) may induce local remodeling of the vascular wall and the WSS pattern in turn depends on vascular geometry. We aimed to elucidate the impact of side-branches on local WSS...
  44. ncbi Association of target organ damage with three arterial stiffness indexes according to blood pressure dipping status in untreated hypertensive patients
    Helen Triantafyllidi
    2nd Department of Cardiology, Attikon Hospital, Medical School, University of Athens, Athens, Greece
    Am J Hypertens 23:1265-72. 2010
    ....
  45. ncbi Dynamics of pulsatile flow in fractal models of vascular branching networks
    Anh Bui
    Division of Materials Science and Engineering, Commonwealth Scientific and Industrial Research Organisation CSIRO, PO Box 56, Highett, Vic, 3190, Australia
    Med Biol Eng Comput 47:763-72. 2009
    ....
  46. ncbi Improved aortic pulse wave velocity assessment from multislice two-directional in-plane velocity-encoded magnetic resonance imaging
    Jos J M Westenberg
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    J Magn Reson Imaging 32:1086-94. 2010
    ..To evaluate the accuracy and reproducibility of aortic pulse wave velocity (PWV) assessment by in-plane velocity-encoded magnetic resonance imaging (MRI)...
  47. ncbi Association between brachial-ankle pulse wave velocity and 3-year mortality in community-dwelling older adults
    Ichiro Miyano
    Department of Public Health, Kochi Medical School, Nankoku, Japan
    Hypertens Res 33:678-82. 2010
    ..Large longitudinal studies for extended periods of time are necessary to confirm the association...
  48. ncbi Brachial-ankle pulse wave velocity predicts all-cause mortality in the general population: findings from the Takashima study, Japan
    Tanvir Chowdhury Turin
    Department of Health Science, Shiga University of Medical Science, Shiga, Japan
    Hypertens Res 33:922-5. 2010
    ..8 (95% confidence interval: 1.4-32.8) as compared with the lowest tertile. The present study demonstrated that increased baPWV is an independent predictor of all-cause mortality in the Japanese population...
  49. ncbi 3-D numerical simulation of blood flow through models of the human aorta
    L Morris
    Centre for Applied Biomedical Engineering Research, Dept Mechanical and Aeronautical Eng and Material and Surface Science Institute, University of Limerick, Castletroy, Limerick, Ireland
    J Biomech Eng 127:767-75. 2005
    ..Flow patterns obtained from transient 3-D computational fluid dynamics are influenced by different reconstruction methods and the pulsatility of the flow. Caution is required when analyzing models based on CT scans...
  50. ncbi An analysis of prospective risk factors for aortic stiffness in men: 20-year follow-up from the Caerphilly prospective study
    Carmel M McEniery
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Box 110, Cambridge CB2 0QQ, UK
    Hypertension 56:36-43. 2010
    ..Adequate control of pulse pressure and heart rate, as well as reducing inflammation, may, in the long-term, retard aortic stiffening, although this remains to be tested directly...
  51. ncbi Numerical modeling of pulsatile turbulent flow in stenotic vessels
    Sonu S Varghese
    School of Mechanical Engineering, Purdue University, West Lafayette, IN 47907, USA
    J Biomech Eng 125:445-60. 2003
    ..Two different experiments were modeled involving pulsatile flow through axisymmetric stenoses...
  52. ncbi Influence of body height on pulsatile arterial hemodynamic data
    H Smulyan
    Department of Medicine, State University of New York Health Science Center, Syracuse 13210, USA
    J Am Coll Cardiol 31:1103-9. 1998
    ..This study sought to present evidence that short stature is a hemodynamic liability, which could explain in part the inverse relation between body height and cardiovascular risk...
  53. ncbi Age-related changes of regional pulse wave velocity in the descending aorta using Fourier velocity encoded M-mode
    Valentina Taviani
    Department of Radiology, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    Magn Reson Med 65:261-8. 2011
    ..There was a preferential stiffening of the thoracic aorta with age, which may be due to progressive fragmentation of elastin fibers in this region...
  54. ncbi Ambulatory arterial stiffness index, pulse wave velocity and augmentation index--interchangeable or mutually exclusive measures?
    Paula Jerrard-Dunne
    Department of Pharmacology and Therapeutics, Trinity College Dublin, Trinity Centre, St James s Hospital, Dublin, Ireland
    J Hypertens 26:529-34. 2008
    ..This index has prompted considerable controversy as to whether it is a true measure of arterial stiffness...
  55. ncbi Evaluation of arterial stiffness in morning hypertension under high-dose valsartan compared to valsartan plus low-dose diuretic
    Takeshi Takami
    Department of Internal Medicine, Clinic Jingumae, Kashihara, Japan
    Hypertens Res 32:1086-90. 2009
    ....
  56. pmc Wave reflection and arterial stiffness in the prediction of 15-year all-cause and cardiovascular mortalities: a community-based study
    Kang Ling Wang
    Departments of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Hypertension 55:799-805. 2010
    ..60 (all P<0.05). In conclusion, Pb, a transit time-independent measure of reflected wave magnitude, predicted long-term cardiovascular mortality in men and women independent of arterial stiffness...
  57. ncbi Numerical validation of a new method to assess aortic pulse wave velocity from a single recording of a brachial artery waveform with an occluding cuff
    B Trachet
    bioMMeda Institute Biomedical Technology, Ghent University, and Department of Pharmacology, Ghent University Hospital, De Pintelaan 185, Block B, 9000, Ghent, Belgium
    Ann Biomed Eng 38:876-88. 2010
    ..Our data indicate that the method picks up wave reflection phenomena confined to the brachial artery, and derived values of PWV rather reflect the stiffness of the brachial arteries...
  58. ncbi Independent prognostic value of the ambulatory arterial stiffness index and aortic pulse wave velocity in a general population
    T W Hansen
    J Hum Hypertens 22:214-6. 2008
  59. ncbi Pulse wave velocity assessment by external noninvasive devices and phase-contrast magnetic resonance imaging in the obese
    Laure Joly
    Centre de Geriatrie et Medecine Interne, CHU de Nancy, rue du Morvan, 54511 Vandoeuvre les Nancy, France
    Hypertension 54:421-6. 2009
    ..Our results indicate that, for body mass index values < or =35 kg m(-2), PWV measured externally with Complior or PulsePen validly reflect values obtained directly in the thoracic aorta through MRI...
  60. ncbi Increased central aortic stiffness and left ventricular mass in normotensive young subjects after successful coarctation repair
    Phalla Ou
    Department of Pediatric Radiology, Hopital Necker Enfants Malades, University Rene Descartes Paris 5, Paris, France
    Am Heart J 155:187-93. 2008
    ..Hypertension occurs in 20% to 40% of survivors of anatomically successful repair of aortic coarctation (CoA). The aim of the present study was to examine the role of central aortic function in this setting...
  61. ncbi Potential and limitations of wave intensity analysis in coronary arteries
    Maria Siebes
    Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Med Biol Eng Comput 47:233-9. 2009
    ..In conclusion, although SPc lacks accuracy in determining local coronary wave speed it is within limits still applicable for wave separation in coronary WIA...
  62. ncbi Comparison of arterial functional evaluations as a predictor of cardiovascular events in hypertensive patients: the Non-Invasive Atherosclerotic Evaluation in Hypertension (NOAH) study
    Minako Terai
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 31:1135-45. 2008
    ..In conclusion, increased aortic stiffness evaluated by PWV is more prognostic of cardiovascular events in hypertensive patients than several non-invasive atherosclerotic evaluations...
  63. ncbi Aortic pulse wave velocity: an independent marker of cardiovascular risk
    Michel E Safar
    Department of Internal Medicine and INSERM U337, Broussais Hospital, 75674 Paris, France
    Am J Geriatr Cardiol 11:295-8. 2002
    ..Since aortic pulse wave velocity is dominantly influenced by age, this finding may be of major importance for the evaluation of cardiovascular risk in geriatric populations...
  64. ncbi Maternal plasma soluble endoglin at 11-13 weeks' gestation in pre-eclampsia
    J M Foidart
    Department of Obstetrics and Gynecology, University of Liege, Liege, Belgium
    Ultrasound Obstet Gynecol 35:680-7. 2010
    ....
  65. ncbi Effects of inhibition of basal nitric oxide synthesis on carotid-femoral pulse wave velocity and augmentation index in humans
    Andrew D Stewart
    Department of Clinical Pharmacology, St Thomas Hospital, King s College, London, UK
    Hypertension 42:915-8. 2003
    ..01 vs norepinephrine and L-NMMA). Effects of inhibition of basal NO release on carotid-femoral PWV can be explained by the change in MAP that this causes rather than any specific effect of NO inhibition within the aorta...
  66. pmc Arterial pulse wave velocity and cognition with advancing age
    Merrill F Elias
    Department of Psychology and Graduate School of Biomedical Sciences, 5472 Little Hall, University of Maine, Orono, ME 04469, USA
    Hypertension 53:668-73. 2009
    ..Early interventions to prevent an increase in arterial stiffness could possibly play an important role in the preservation of cognitive ability...
  67. ncbi Association between resting heart rate and arterial stiffness in Korean adults
    Byoung Jin Park
    Department of Family Medicine, Yonsei University College of Medicine, Gangnam Gu, Seoul, Republic of Korea
    Arch Cardiovasc Dis 103:246-52. 2010
    ..Higher resting heart rate, a simple and useful indicator of autonomic balance and metabolic rate, has emerged as an independent predictor for atherosclerotic cardiovascular disease...
  68. ncbi Correlates of aortic stiffness in elderly individuals: a subgroup of the Cardiovascular Health Study
    Rachel H Mackey
    Department of Epidemiology, University of Pittsburgh, Graduate School of Public Health, PA 15261, USA
    Am J Hypertens 15:16-23. 2002
    ..Arterial stiffness has been associated with aging, hypertension, and diabetes; however, little data has been published examining risk factors associated with arterial stiffness in elderly individuals...
  69. pmc Sensitivity and specificity of pulse detection using a new deconvolution method
    Peter Y Liu
    Endocrine Research Unit, Department of Internal Medicine, Mayo Medical School, Mayo School of Graduate MedicalEducation, Center for Translational Science Activities, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Physiol Endocrinol Metab 297:E538-44. 2009
    ..We conclude that an objective automated pulse detection deconvolution procedure has high sensitivity and specificity, thus offering a platform for quantitative neuroendocrine analyses...
  70. ncbi Noninvasive (input) impedance, pulse wave velocity, and wave reflection in healthy middle-aged men and women
    Patrick Segers
    Cardiovascular Mechanics and Biofluid Dynamics, IBITECH, Ghent University, De Pintelaan 185, B 9000 Gent, Belgium
    Hypertension 49:1248-55. 2007
    ..Wave reflection increases with age and is not higher in women than in men...
  71. ncbi Ocular blood flow and systemic blood pressure in patients with primary open-angle glaucoma and ocular hypertension
    Gabriele Fuchsjager-Mayrl
    Departments of Clinical Pharmacology and Ophthalmology, and the Institute of Medical Physics, University of Vienna, Vienna, Austria
    Invest Ophthalmol Vis Sci 45:834-9. 2004
    ..In the present study, the baseline characteristics were examined in a study population participating in a clinical trial in which the ocular hemodynamic effects of timolol and dorzolamide were compared...
  72. pmc Wall shear stress as measured in vivo: consequences for the design of the arterial system
    Robert S Reneman
    Department of Physiology, Cardiovascular Research Institute Maastricht, University of Maastricht, POB 616, 6200 MD Maastricht, The Netherlands
    Med Biol Eng Comput 46:499-507. 2008
    ..The cells have to be studied under the shear stress conditions they are exposed to in real life...
  73. ncbi Feasibility of aortic pulse pressure and pressure wave velocity MRI measurement in young adults
    Eric Laffon
    Service de Medecine Nucleaire, Hopital du Haut leveque, Pessac, France
    J Magn Reson Imaging 21:53-8. 2005
    ..To investigate the feasibility of assessing, noninvasively, aortic pulse pressure (APP) and pulse wave velocity (PWV) in the ascending aorta of young adults by means of velocity-encoded magnetic resonance (MR) imaging...
  74. ncbi Pulsatile stretch and shear stress: physical stimuli determining the production of endothelium-derived relaxing factors
    R Busse
    Institut für Kardiovaskuläre Physiologie, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Deutschland, Germany
    J Vasc Res 35:73-84. 1998
    ..Rhythmic vessel distension is also able to elicit the synthesis of superoxide anions and the endothelium-derived hyperpolarizing factor which play a role in modulating arterial compliance in certain vascular beds...
  75. pmc Hemodynamic patterns of anterior communicating artery aneurysms: a possible association with rupture
    M A Castro
    Department of Computational and Data Sciences, College of Sciences, George Mason University, Fairfax, VA, USA
    AJNR Am J Neuroradiol 30:297-302. 2009
    ..The purpose of this study was to characterize the different flow types present in AcomA aneurysms and to investigate possible associations with rupture...
  76. ncbi Luteinizing hormone pulsatility is disrupted at a threshold of energy availability in regularly menstruating women
    Anne B Loucks
    Department of Biological Sciences, Ohio University, Athens, Ohio 45701, USA
    J Clin Endocrinol Metab 88:297-311. 2003
    ....
  77. ncbi First-trimester maternal serum pregnancy-associated plasma protein-A and pre-eclampsia
    L C Y Poon
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
    Ultrasound Obstet Gynecol 33:23-33. 2009
    ..To examine the relationship between low maternal serum pregnancy-associated plasma protein-A (PAPP-A) and uterine artery pulsatility index (UtA-PI) at 11+0 to 13+6 weeks with subsequent development of pre-eclampsia (PE)...
  78. ncbi Measures of obesity are associated with vascular stiffness in young and older adults
    Rachel P Wildman
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Hypertension 42:468-73. 2003
    ..The strength of the association, the early age at which it appears, and the prevalence of obesity among the young warn of substantially increased cardiovascular disease incidence as this cohort ages...
  79. ncbi The clinical and cost-effectiveness of pulsatile machine perfusion versus cold storage of kidneys for transplantation retrieved from heart-beating and non-heart-beating donors
    J Wight
    The School of Health and Related Research, University of Sheffield, UK
    Health Technol Assess 7:1-94. 2003
    ..Transplantation of kidneys from both heart-beating donors (HBDs) and non-heart-beating donors (NHBDs) is considered. Finally to review whether the use of MP can allow valid testing of kidney viability prior to transplantation...
  80. pmc Arterial destiffening with weight loss in overweight and obese middle-aged and older adults
    A Laura Dengo
    Human Integrative Physiology Laboratory, Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Hypertension 55:855-61. 2010
    ..In summary, our findings indicate that weight loss reduces arterial stiffness in overweight/obese middle-aged and older adults, and the magnitudes of these improvements are related to the loss of total and abdominal adiposity...
  81. ncbi Beat-to-beat noninvasive stroke volume from arterial pressure and Doppler ultrasound
    Johannes J van Lieshout
    Room F7 205, Academic Medical Center, Department of Internal Medicine and Cardiovascular Research Institute Amsterdam, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Eur J Appl Physiol 90:131-7. 2003
    ..Systematic differences appear during HUT30 and show opposite signs. The difference between the two methods upon a change in body position may be attributed to limitations in each method...
  82. pmc Measuring aortic pulse wave velocity using high-field cardiovascular magnetic resonance: comparison of techniques
    El Sayed H Ibrahim
    Department of Radiology, University of Florida College of Medicine, Jacksonville, Florida, USA
    J Cardiovasc Magn Reson 12:26. 2010
    ..However, assessment and comparison of these techniques at high field strength has not yet been performed. In this work, the TT, QA, and XC techniques were clinically tested at 3 Tesla and compared to each other...
  83. ncbi Numerical study of nonlinear pulsatile flow in S-shaped curved arteries
    A K Qiao
    Medical School of Shantou University, Shantou, Guangdong 515031, PR China
    Med Eng Phys 26:545-52. 2004
    ..The comprehensive theoretical foundation showed in the present study can be extended to approach problems of nonlinear pulsatile flow in curved arteries with more complex geometrical shape.
  84. ncbi Two-equation turbulence modeling of pulsatile flow in a stenosed tube
    J Ryval
    The Department of Mechanical and Materials Engineering, The University of Western Ontario, London, Ontario, Canada, N6A 5B9
    J Biomech Eng 126:625-35. 2004
    The study of pulsatile flow in stenosed vessels is of particular importance because of its significance in relation to blood flow in human pathophysiology...
  85. ncbi Pulsatile flow studies of a porcine bioprosthetic aortic valve in vitro: PIV measurements and shear-induced blood damage
    W L Lim
    Department of Mechanical Engineering, Faculty of Engineering, National University of Singapore, 9 Engineering Drive 1, 117576 Singapore, Singapore
    J Biomech 34:1417-27. 2001
    ..immediate downstream vicinity of a porcine bioprosthetic heart valve at the aortic root region in vitro under pulsatile flow conditions...
  86. ncbi The effect of proximal artery flow on the hemodynamics at the distal anastomosis of a vascular bypass graft: computational study
    S M Kute
    Department of Surgery, University of Pittsburgh, PA 15213, USA
    J Biomech Eng 123:277-83. 2001
    ..Since surgeons have some control over the flow condition in the proximal artery, results from this study could help determine which flow condition is clinically optimal...
  87. ncbi Vascular compliance is reduced in vascular dementia and not in Alzheimer's disease
    Sasha Dhoat
    Faculty of Medicine, Imperial College, London, UK
    Age Ageing 37:653-9. 2008
    ..to determine whether functional changes in the vasculature differ between Alzheimer's disease (AD) and vascular dementia (VAD)...
  88. ncbi The role of pulsatile flow in controlling microvascular retinal endothelial and pericyte cell apoptosis and proliferation
    Tony E Walshe
    Vascular Health Research Centre, Faculty of Science and Health, Dublin City University, Dublin 9, Ireland
    Cardiovasc Res 89:661-70. 2011
    ..We examined the effects of pulsatile flow on bovine retinal endothelial cell (BREC) and bovine retinal pericyte (BRP) apoptosis and proliferation.
  89. ncbi Cyclic changes in blood echogenicity under pulsatile flow are frequency dependent
    Linh Chi Nguyen
    Laboratory of Biorheology and Medical Ultrasonics, Centre hospitalier de l Université de Montréal CHUM Hôpital Notre Dame, Montreal, Quebec, Canada
    Ultrasound Med Biol 34:664-73. 2008
    Previous in vivo and in vitro studies have demonstrated that blood echogenicity varies under pulsatile flow, but such changes could not always be measured at physiological stroke rates...
  90. pmc Relationship between intima-media thickness of the common carotid artery and arterial stiffness in subjects with and without type 2 diabetes: a case-series report
    Manuel Angel Gómez-Marcos
    Primary Care Research Unit, La Alamedilla Health Center, Salamanca, Spain
    Cardiovasc Diabetol 10:3. 2011
    ....
  91. ncbi Detection of a relation between respiration and CSF pulsation with an echoplanar technique
    U Klose
    Section of Experimental MR of the CNS, Department of Neuroradiology, University of Tubingen, D 72076 Tubingen, Germany
    J Magn Reson Imaging 11:438-44. 2000
    ..In the late expiration phase the caudally directed flow was at its maximum, whereas the cranially directed flow was maximal in the post-inspiration phase...
  92. pmc Consistency of aortic distensibility and pulse wave velocity estimates with respect to the Bramwell-Hill theoretical model: a cardiovascular magnetic resonance study
    Anas Dogui
    INSERM U678, Paris, France
    J Cardiovasc Magn Reson 13:11. 2011
    ..This study aimed at evaluating the consistency of the automated estimation of regional and local aortic stiffness indices from cardiovascular magnetic resonance (CMR) data...
  93. ncbi Arterial stiffness, physical function, and functional limitation: the Whitehall II Study
    Eric J Brunner
    Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK
    Hypertension 57:1003-9. 2011
    ..The nature of the link between arterial stiffness and quality of life in older people merits attention...
  94. ncbi The respiratory modulation of intracranial cerebrospinal fluid pulsation observed on dynamic echo planar images
    Yi Hsuan Kao
    Department of Biomedical Imaging and Radiological Sciences, National Yang Ming University, Taipei 112, Taiwan, ROC
    Magn Reson Imaging 26:198-205. 2008
    ..In breath-holding experiments, respiratory rhythm suppression and vessel dilation were observed in 8 and 10 subjects, respectively. Information obtained from this study further elucidates the respiratory modulation of CSF in vivo...
  95. ncbi Pulse wave velocity reference values in healthy adults aged 26-75 years
    T Koivistoinen
    Department of Clinical Physiology, Medical School, University of Tampere, and Tampere University Hopsital, Tampere, Finland
    Clin Physiol Funct Imaging 27:191-6. 2007
    ..Reference values can be useful in the clinical management of patients, especially in detecting early vascular disease or an increased risk of cardiovascular complications...
  96. ncbi Physiologic pulsatile flow bioreactor conditioning of poly(ethylene glycol)-based tissue engineered vascular grafts
    Mariah S Hahn
    Rice University, Department of Bioengineering, Houston, TX, USA
    Ann Biomed Eng 35:190-200. 2007
    ..A pulsatile flow bioreactor was developed to allow shear and pulsatile stimulation of TEVGs...
  97. pmc Studies of isolated global brain ischaemia: III. Influence of pulsatile flow during cerebral perfusion and its link to consistent full neurological recovery with controlled reperfusion following 30 min of global brain ischaemia
    Bradley S Allen
    Department of Surgery, University of California, Los Angeles, CA, USA
    Eur J Cardiothorac Surg 41:1155-63. 2012
    ....
  98. ncbi Perfusion bioreactor for small diameter tissue-engineered arteries
    Chrysanthi Williams
    School of Chemical and Biomolecular Engineering, Wallace H Coulter Department of Biomedical Engineering, and Parker H Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, USA
    Tissue Eng 10:930-41. 2004
    ..were seeded onto porous tubular poly(glycolic acid) nonwoven scaffolds and cultured in the bioreactor under pulsatile flow conditions for up to 25 days...
  99. ncbi Time-resolved DPIV investigation of pulsatile flow in symmetric stenotic arteries--effects of phase angle
    Satyaprakash Karri
    School of Biomedical Engineering and Sciences, Virginia Tech, Blacksburg, VA 24061, USA
    J Biomech Eng 132:031010. 2010
    ....
  100. ncbi Arterial stiffness, wave reflections, and the risk of coronary artery disease
    Thomas Weber
    Cardiology Department of the General Hospital of the Kreuzschwestern, Wels, Austria
    Circulation 109:184-9. 2004
    ..Increased arterial stiffness, determined invasively, has been shown to predict a higher risk of coronary atherosclerosis. However, invasive techniques are of limited value for screening and risk stratification in larger patient groups...
  101. ncbi Doppler evaluation of peripheral vascular adaptations to transverse aortic banding in mice
    Yi Heng Li
    Section of Cardiovascular Sciences, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Ultrasound Med Biol 29:1281-9. 2003
    ..Additionally, we validated that the simplified Bernoulli equation (DeltaP=4V2) can be used to estimate the pressure drop across the aortic band in mice noninvasively...

Research Grants63

  1. Biotechnology Based Fetal Pulmonary Tissue Engineering
    Christine Finck; Fiscal Year: 2006
    ..system to enable the continuous bathing of these 3-D constructs with nutrients as well as subject them to pulsatile flow induced shear forces...
  2. Aldosterone, Autophagy, and Arterial Stiffness
    Jane A Leopold; Fiscal Year: 2013
    ..is also recognized that increased aorta stiffness, which exposes resistance vessels of the microvasculature to pulsatile flow, results in microvascular remodeling...
  3. Transcranial Sonothrombolysis with Diagnostic Ultrasound
    Thilo Hoelscher; Fiscal Year: 2013
    ..has been established which allows us to study thrombolysis of human whole blood clots exposed to circulating, pulsatile flow and to acquire the acoustic properties at the clot site simultaneously...
  4. Biomechanical Mechanisms of Artery Tortuosity
    Hai Chao Han; Fiscal Year: 2013
    ..Methods: Artery buckling will be examined using biomechanics-based modeling and experimental tests under pulsatile flow conditions...
  5. Compliant Thoracic Artificial Lungs
    KEITH ELLIOT COOK; Fiscal Year: 2012
    ..3) The selected design will be tested in-vitro under pulsatile flow to confirm hemodynamic performance...
  6. Improved stent design through hemodynamics and vascular biology
    Juan Miguel Jimenez; Fiscal Year: 2013
    ..Aim 2 will address the hypothesis that pulsatile flow characteristics in the vicinity of streamlined and conventional stent strut geometries influences endothelial ..
  7. Non-Contrast Magnetic Resonance Angiography of Peripheral Vascular Disease
    Robert R Edelman; Fiscal Year: 2013
    ..Ghost MRA uses the ghost artifacts generated by pulsatile flow to create an MRA with no signal contribution from background tissues...
  8. Synchronous Valveless Pulsatile Support Device for the Failing Heart
    RICHARD WARREN SMALLING; Fiscal Year: 2013
    ..of bench top and animal studies successfully demonstrated the feasibility and superiority of synchronized pulsatile flow as compared to continuous flow support...
  9. INTERSTITIAL FLUID FLOW IN BONE REMODELING
    John A Frangos; Fiscal Year: 2012
    ..2) Determine the mechanisms for the nitric oxide-related mechanochemical signal transduction pathways of pulsatile flow and ramped steady flow in osteoblasts and osteocytes...
  10. 3D Acellular Vascular Beds: Characterization and Re-endothelialization
    Christine E Schmidt; Fiscal Year: 2012
    ..Once seeded, these transdifferentiated hMSCs will be subjected to pulsatile flow, to precondition the cells for physiological stresses that are found in the native vascular system...
  11. Pulsatile Flow Regulation of Vascular Cell Fate
    DAVID JOHN MORROW; Fiscal Year: 2010
    ..The proposed study fits well with the NIH mission to "extend healthy life and reduce the burdens of illness and disability". ..
  12. Pulsatile Flow Regulation of Vascular Cell Fate
    DAVID JOHN MORROW; Fiscal Year: 2013
    ..of both Hh and Notch signaling components in SMC, our central hypothesis is that Hh mediates flow-induced changes in SMC growth (proliferation and apoptosis) and migration via regulation of VEGF/ Notch signaling ..
  13. Non-Contrast-Enhanced Peripheral MR Angiography
    Vivian S Lee; Fiscal Year: 2013
    ..Our aims are (1) To systematically develop, test, and refine peripheral vascular 3D VFA-FSE MRA using pulsatile flow phantoms and human subjects, (2) To develop and test dynamic 4D VFA-FSE imaging that incorporates variable ..
  14. Bioprinting With Cells from Adipose Stromal Vascular Fraction
    Benjamin Shepherd; Fiscal Year: 2010
    ..vessel fabrication results in a scaffold-free bioengineered blood vessel, which can be further matured under pulsatile flow conditions in a perfusion bioreactor to yield blood vessel constructs with appropriate cellular and matrix ..
  15. Development of a Pediatric Ventricular Assist Device
    WEISS WILLIAM J; Fiscal Year: 2009
    ..This approach is advantageous in pediatric applications because the system provides pulsatile flow, is relatively non-thrombogenic, is durable, and may be used for uni-ventricular or bi-ventricular support...
  16. MECHANISMS OF PROSTHETIC ARTERIAL GRAFT FAILURE
    Frank W LoGerfo; Fiscal Year: 2013
    ..determine optimal physical properties that it requires for effective siRNA delivery to the vasculature under pulsatile flow and operating room conditions and, 3) implant the graft prototype in a large canine animal model, after ..
  17. Engineered Artery Growth in Vitro Based on Cell-Remodeled Fibrin
    Robert T Tranquillo; Fiscal Year: 2010
    ..construct with the blood outgrowth endothelial cells (BOECs) noted above, including their adhesion strength in pulsatile flow at physiological shear stress and their state of activation...
  18. Bone Tissue Engineerig: Effect of Dynamic Perfusion
    Aaron Goldstein; Fiscal Year: 2009
    ..Therefore, the goals of this project are 1) to probe the mechanisms by which pulsatile flow induces expression of BMPs and VEGF-A, and 2) to implement a non-destructive imaging modality to monitor ..
  19. Quantification of Blood Volume Flow Using Ultrasound
    JEFFREY B FOWLKES; Fiscal Year: 2010
    ..This technique has already demonstrated volume flow measurements in steady state and pulsatile flow in phantoms and in arterial flow in a canine model...
  20. A Novel Pediatric Pulsatile Rotary Ventricular Pump
    DANIEL EDWARD MAZUR; Fiscal Year: 2010
    ..A physiologic pulsatile flow is created under constant RPM conditions through a novel lengthwise variation of the pumping chamber geometry...
  21. NEW METHODOLOGIES FOR THE DESIGN OF SMALL BLOOD PUMPS
    Gerson Rosenberg; Fiscal Year: 2013
    ..location, severity, and time course of thrombosis and embolization, 2) study the effect of pump speed and pulsatile flow, and 3) measure platelet activation, global coagulation, hemolysis, and biomarkers of renal ischemia...
  22. INTRATHORACIC ARTIFICIAL LUNGS
    LYLE MOCKROS; Fiscal Year: 2000
    ..In-vitro studies will examine, in a controlled setting, effect of pulsatile flow on gas transfer and hemodynamic characteristics of the device and of shear stress and various fiber surface ..
  23. Reduction of Thromboembolic Potential in Cardiac Devices Via Passive Flow Control
    Ajit P Yoganathan; Fiscal Year: 2010
    ..be implemented using miniature vortex generators in order to alleviate the instantaneous shear stresses of the pulsatile flow in between the leaflets and thereby significantly reduce shear-induced blood damage...
  24. SURGICAL CORDIOPULMONARY BYPASS AND CEREBRAL RESISTANCE
    William Johnston; Fiscal Year: 1993
    ..upon the duration of antecedent hypothermia and only partially resolves after 4 hours of normothermic pulsatile flow. Clinical studies of cardiopulmonary bypass are limited by the hemodynamic parameters which can be measured ..
  25. TECHNIQUES FOR DETECTION OF LESIONS IN CORONARY ARTERIES
    HOWARD KANTOR; Fiscal Year: 1991
    ..in the following systems: a) a phantom 2-5 mm polyvinyl chloride tubing model of coronary stenosis with pulsatile flow and associated with a model of respiratory related motion, b) a porcine model of coronary atherogenesis ..
  26. CARDIOPULMONARY GEOMETRY AND BLOOD FLOW
    Carol Lucas; Fiscal Year: 1991
    ..The similarity of animal velocity profiles in vivo to profiles obtained in pulsatile flow studies in curved tubes suggests that geometry plays a role as important as hemodynamics in determining ..
  27. Perfusion System for In Utero Cardiac Surgery
    SARAH MONTAG; Fiscal Year: 2007
    ..cardiac bypass circuit designed to minimize placental dysfunction by minimizing priming volume, delivering pulsatile flow, and providing adequate gas exchange when the placenta is excluded from the fetal circulation...
  28. MICRORHEOLOGIC MECHANISMS IN VASCULAR PATHOPHYSIOLOGY
    SALVATORE SUTERA; Fiscal Year: 1992
    ..deformability; to study mechanisms of shear-induced platelet alterations, particularly under conditions of pulsatile flow. In the longer term the applicability of the rheoscope to the study of white cell rheology will be tested...
  29. MAGNETIC RESONANCE CORONARY ANGIOGRAPHY
    John Oshinski; Fiscal Year: 2001
    ..study are: 1) Conduct model studies on realistic stenotic coronary flow phantoms with respiratory motion and pulsatile flow to: a) compare 2D and 3D acquisition methods and optimize the most promising approach, b) determine the impact ..
  30. INFLUENCE OF FLOW DYNAMICS ON THROMBOGENESIS
    RICHARD SCHOEPHOERSTER; Fiscal Year: 1991
    ..will be a fundamental approach by analyzing the flow in various geometries of flow chambers in both steady and pulsatile flow loops. These flow chambers will create different combinations of these flow phenomena...
  31. WALL SHEAR STRESS IN THE CARDIOVASCULAR SYSTEM
    JOHN TARBELL; Fiscal Year: 2003
    ..transport processes in a realistic 3-dimensional, elastic (moving wall) model of the carotid bifurcation under pulsatile flow conditions using a finite element code (FIDAP 8.5)...
  32. VASCULAR RESPONSE TO ALTERATION IN HEMODYNAMIC FLOW
    SHUNICHIRO OKADA; Fiscal Year: 2002
    ..co-culture in vitro system, we will determine if there is an EC influence on SIVIC migration in response to pulsatile flow. In specific aim 2, we will determine if pulsatile flow alters EC PAI-1 expression in the presence of SMC...
  33. Spectral-Encoding for Video-Rate Hemodynamic Tomography
    Brian Pogue; Fiscal Year: 2005
    ..The hemodynamic response in terms of pulsatile flow in the brain will be imaged in the rat brain, as well as indocyanine green kinetics...
  34. ULTRASONIC SCATTERING BY BIOLOGICAL TISSUES
    K Shung; Fiscal Year: 2001
    ..properties of whole blood and erthyrocyte suspensions under well-defined flow conditions under steady and pulsatile flow either in an in vitro mock flow loop or in vivo on pigs...
  35. Venoarterial ECMO and neonatal cerebrovascular injury
    Billie Short; Fiscal Year: 2004
    ..Aim I is to test the hypothesis that non-pulsatile flow in cerebral arteries impairs basal and stimulated release of NO...
  36. Spectral-Encoding for Video-Rate Hemodynamic Tomography
    Brian Pogue; Fiscal Year: 2007
    ..The hemodynamic response in terms of pulsatile flow in the brain will be imaged in the rat brain, as well as indocyanine green kinetics...
  37. FLOW-INDUCED NEAR-WALL EXCESS OF PLATELETS
    Eugene Eckstein; Fiscal Year: 1993
    ..are chosen to facilitate modelling with mass transport theory; these situations include axial development, pulsatile flow, and transient development of the local concentration...
  38. ENGINEERED CARDIAC MORPHOGENESIS--STEM CELLS & SCAFFOLDS
    Buddy Ratner; Fiscal Year: 2004
    ..The 'tube hearts' will be conditioned in pulsatile flow circuits, assessed for mechanical performance in vitro, and eventually grafted into aortas of syngeneic rats ..
  39. ALTERNATIVES TO ECMO FOR PEDIATRIC CIRCULATORY SUPPORT
    George Pantalos; Fiscal Year: 2002
    ..patients requiring circulatory support, efforts are being made to develop reliable continuous flow (CF) and pulsatile flow (PF) ventricular assist devices (VADs) appropriate for neonates and infants...
  40. FLOW VELOCITY QUANTITATION BY MRI
    David Saloner; Fiscal Year: 1993
    ..This will be accomplished by: Simulating the flow patterns and magnetization distribution for steady and pulsatile flow through regular and irregular vessels in response to velocity quantitation pulse sequences...
  41. ENHANCED CAROTID BIFURCATION PHANTOM FOR MRI/A
    Thomas Burke; Fiscal Year: 2000
    ..Branching vessels are anatomically accurate and will exhibit proper vessel distention and translation under pulsatile flow (Aim 3)...
  42. Gordon Research Conference on Assisted Circulation
    Harvey Borovetz; Fiscal Year: 2003
    ..Speakers will review the history of assisted circulation; evaluate the strengths and limitations of current pulsatile flow devices; critique the potential of rotary-based blood pumps as an alternative-to-cardiac transplantation and ..
  43. An Artificial Myocardium for Pediatric Support
    Robert Stewart; Fiscal Year: 2003
    ..centrifugal pumps, usually with extracorporeal membrane oxygenation (ECMO)). The design chosen will provide pulsatile flow without issues related to either blood volume or thrombus formation...
  44. Antithrombin targeting to HSPG & heparin coated surfaces
    Susan Bock; Fiscal Year: 2006
    ..1 will investigate mass transport effects on super-beta-ATIII surface delivery under low-vs-high and steady-vs-pulsatile flow, using simulations, an in vitro flow model, and lumenal surface analysis of rabbit blood vessels...
  45. ECAD:Enhanced Coronary Artery Disease Phantom for MRA
    Thomas Burke; Fiscal Year: 2006
    ..cardiac functionality, 3) verifying eCAD is anatomically accurate with proper flow patterns and motion under pulsatile flow conditions and 4) demonstrating prototype reproducibility, stability and commercial potential during extended ..
  46. REAL TIME DIGITAL ULTRASOUND IMAGE SPECKLE VELOCIMETRY
    Morteza Gharib; Fiscal Year: 2000
    ..Optical DPIV was pioneered in this group and has been used frequently for in vitro pulsatile flow studies...
  47. ENHANCED CAROTID BIFURCATION PHANTOM FOR MRI/A
    Thomas Burke; Fiscal Year: 2003
    ..3) image morphology, including two distinct layers with fibrous cap lesion and 4) fluid motion with custom pulsatile flow pump and experimental results compared to hemodynamic simulations...
  48. Retinal Hemodynamic Imaging with Tracking Doppler Flowmetry
    R Ferguson; Fiscal Year: 2006
    ..flow changes in relation to visual stimulus-evoked neuro-vascular coupling mechanisms; and 3) enable detailed pulsatile flow phase portraits across a range of vessel sizes and flow velocity by synchronization to the cardiac cycle...
  49. UNSTEADY FLOW IN ARTERIAL BIFURCATIONS
    C Dewey; Fiscal Year: 1980
    ..measurements of the wall shear stress, wall pressure, and detailed intralumenal flow patterns produced by pulsatile flow through models of arterial bifurcations...
  50. Pulsatile Pediatric Blood Pump Development-Phase II
    Mark Gartner; Fiscal Year: 2005
    ..0 Lpm through pediatric-sized cannulas. Increasingly, evidence suggests that pulsatile flow is more physiologic and may in fact be beneficial to pediatric patients as compared to continuous flow blood ..
  51. Tissue-engineering Valve from Cell-Remodeled Biopolymer
    Robert Tranquillo; Fiscal Year: 2007
    ..A coupled solid fluid mechanical model of valve function in pulsatile flow will be used to define what alignment-dependent mechanical properties of our "valve-equivalent" (VE)are ..
  52. Hemodynamic Assessment of Renal Artery Disease
    James Barry; Fiscal Year: 2006
    ..Two alternative model-based approaches for this evaluation will be developed in the proposed project. A pulsatile flow phantom will be constructed and tested to provide anatomic and flow/pressure data for model development and ..
  53. BIOENGINEERING-BIOLOGIC STUDY OF NON-PULSATILE PERFUSION
    Bartley Griffith; Fiscal Year: 2003
    ..Consequently, the proposed study is being undertaken to investigate chronic non-pulsatile flow from the point of view of physiologic endpoints which are known to be important in the clinical setting of ..
  54. Mechanical and Molecular Bases of Endothelial Remodeling
    Shu Chien; Fiscal Year: 2009
    ..characteristics in comparison to those in the straight parts of the arterial tree, which are exposed to pulsatile flow with a large net forward direction...
  55. HEMODYNAMIC REGULATION OF VASCULAR SMOOTH MUSCLE CELL
    Paul Cahill; Fiscal Year: 1999
    ..smooth muscle cells can be simultaneously chronically exposed to physiological shear stress and cyclic strain (pulsatile flow), we will define the acute and chronic effects of flow on: (i) endothelial release of anti-mitogenic ..
  56. SMALL AUTOMATED MECHANICAL HEART-LUNG SYSTEM
    JD MORTENSEN; Fiscal Year: 1993
    ..Incorporated within the proposed new device is a pulsatile flow, bladder type pump-reservoir in which is deployed a blood-on-the-outside/gas-on-the-inside hollow fiber ..
  57. HEMODYNAMIC REGULATION OF VASCULAR SMOOTH MUSCLE CELL
    EILEEN REDMOND; Fiscal Year: 2001
    ..smooth muscle cells can be simultaneously chronically exposed to physiological shear stress and cyclic strain (pulsatile flow), we will define the acute and chronic effects of flow on: (i) endothelial release of anti-mitogenic ..
  58. BIOENGINEERING-BIOLOGIC STUDY OF NON-PULSATILE PERFUSION
    Bartley Griffith; Fiscal Year: 2002
    ..Consequently, the proposed study is being undertaken to investigate chronic non-pulsatile flow from the point of view of physiologic endpoints which are known to be important in the clinical setting of ..
  59. THE AGING GH AXIS IN POSTMENOPAUSAL WOMEN
    Johannes Veldhuis; Fiscal Year: 2005
    ..An enhanced knowledge base should aid ultimately in formulating more innovative preventive and interventional strategies to limit hyposomatotropism in older and/or estrogen-deficient humans. ..
  60. A central aortic pulse wave velocity measurement device
    Gary Mitchell; Fiscal Year: 2005
    ..This innovative technology will enable accurate diagnosis and risk stratification in a primary care setting and will facilitate further research aimed at evaluating interventions that may reduce conduit vessel stiffness. ..
  61. INTERSTITIAL FLUID FLOW IN BONE REMODELING
    John Frangos; Fiscal Year: 2007
    ..2) Determine the mechanisms for the nitric oxiderelated mechanochemical signal transduction pathways of pulsatile flow and ramped steady flow in osteoblasts...
  62. Analytical Reconstruction of Feedback Signaling in Aging Men
    Johannes Veldhuis; Fiscal Year: 2008
    ..The present proposal develops a general biomathematical framework for dissecting otherwise observed pathways that control hormone output in aging, stress and disease. [unreadable] [unreadable] [unreadable]..
  63. Mechanistic bases for age-related androgen deficiency
    Johannes Veldhuis; Fiscal Year: 2007
    ..Knowing why testosterone falls should help foster new and safer ways to prevent the problem. [unreadable] [unreadable] [unreadable]..