laser doppler flowmetry

Summary

Summary: A method of non-invasive, continuous measurement of microcirculation. The technique is based on the values of the Doppler effect of low-power laser light scattered randomly by static structures and moving tissue particulates.

Top Publications

  1. ncbi An audit of the use of laser Doppler imaging (LDI) in the assessment of burns of intermediate depth
    S A Pape
    Royal Victoria Infirmary, NE1 4LP, Newcastle upon Tyne, UK
    Burns 27:233-9. 2001
  2. ncbi Wavelet analysis of oscillations in the peripheral blood circulation measured by laser Doppler technique
    A Stefanovska
    Faculty of Electrical Engineering, University of Ljubljana, Slovenia
    IEEE Trans Biomed Eng 46:1230-9. 1999
  3. ncbi Human skin microcirculation after brachial plexus block evaluated by wavelet transform of the laser Doppler flowmetry signal
    Svein A Landsverk
    Department of Anesthesiology, Ulleval University Hospital, Oslo, Norway
    Anesthesiology 105:478-84. 2006
  4. ncbi Review of methodological developments in laser Doppler flowmetry
    Vinayakrishnan Rajan
    Institute of Biomedical Technology, Biophysical Engineering Group, University of Twente, P O Box 217, 7500AE, Enschede, The Netherlands
    Lasers Med Sci 24:269-83. 2009
  5. ncbi Effect of ischemic preconditioning on rat liver microcirculation monitored with laser Doppler flowmetry
    Attila Szijarto
    Department of Surgery, Semmelweis University, Budapest, Hungary
    J Surg Res 131:150-7. 2006
  6. pmc Pulse transit times to the capillary bed evaluated by laser Doppler flowmetry
    Alan Bernjak
    Faculty of Electrical Engineering, University of Ljubljana, Trzaska 25, 1000 Ljubljana, Slovenia Physics Department, Lancaster University, LA1 4YB, UK
    Physiol Meas 30:245-60. 2009
  7. ncbi Pulp revascularization of replanted immature dog teeth after treatment with minocycline and doxycycline assessed by laser Doppler flowmetry, radiography, and histology
    Alessandra Luisa de Souza Ritter
    Department of Endodontics, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7450, USA
    Dent Traumatol 20:75-84. 2004
  8. ncbi Comparison of near-infrared spectroscopy and laser Doppler flowmetry for detecting decreased hepatic inflow in the porcine liver
    Junichi Kaneko
    Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Invest Surg 22:268-74. 2009
  9. ncbi Dose-dependent vasodilatory effects of acetylcholine and local warming on skin microcirculation
    Samuel Christen
    Division of Clinical Pathophysiology, University Hospital, Lausanne, Switzerland
    J Cardiovasc Pharmacol 44:659-64. 2004
  10. ncbi Reproducibility and methodological issues of skin post-occlusive and thermal hyperemia assessed by single-point laser Doppler flowmetry
    M Roustit
    Inserm CIC3, Grenoble Clinical Research Center, Grenoble University Hospital, France
    Microvasc Res 79:102-8. 2010

Detail Information

Publications276 found, 100 shown here

  1. ncbi An audit of the use of laser Doppler imaging (LDI) in the assessment of burns of intermediate depth
    S A Pape
    Royal Victoria Infirmary, NE1 4LP, Newcastle upon Tyne, UK
    Burns 27:233-9. 2001
    ..We recommend that all burns of intermediate depth should be analysed in this way in order to ensure appropriate management of the burn, to avoid unnecessary surgery and to reduce hospital stay and costs...
  2. ncbi Wavelet analysis of oscillations in the peripheral blood circulation measured by laser Doppler technique
    A Stefanovska
    Faculty of Electrical Engineering, University of Ljubljana, Slovenia
    IEEE Trans Biomed Eng 46:1230-9. 1999
    ..frequency resolution, was used to analyze oscillations in human peripheral blood flow measured by laser Doppler flowmetry. The oscillations extended over a wide frequency scale and their periods varied in time...
  3. ncbi Human skin microcirculation after brachial plexus block evaluated by wavelet transform of the laser Doppler flowmetry signal
    Svein A Landsverk
    Department of Anesthesiology, Ulleval University Hospital, Oslo, Norway
    Anesthesiology 105:478-84. 2006
    The skin microcirculation may be evaluated noninvasively by laser Doppler flowmetry and iontophoresis with acetylcholine and sodium nitroprusside...
  4. ncbi Review of methodological developments in laser Doppler flowmetry
    Vinayakrishnan Rajan
    Institute of Biomedical Technology, Biophysical Engineering Group, University of Twente, P O Box 217, 7500AE, Enschede, The Netherlands
    Lasers Med Sci 24:269-83. 2009
    b>Laser Doppler flowmetry is a non-invasive method of measuring microcirculatory blood flow in tissue. In this review the technique is discussed in detail. The theoretical and experimental developments to improve the technique are reviewed...
  5. ncbi Effect of ischemic preconditioning on rat liver microcirculation monitored with laser Doppler flowmetry
    Attila Szijarto
    Department of Surgery, Semmelweis University, Budapest, Hungary
    J Surg Res 131:150-7. 2006
    ..This study investigated the effect of IP on hepatic microcirculation (HM) and analyzed the objective parameters of the HM using laser Doppler flowmetry (LDF).
  6. pmc Pulse transit times to the capillary bed evaluated by laser Doppler flowmetry
    Alan Bernjak
    Faculty of Electrical Engineering, University of Ljubljana, Trzaska 25, 1000 Ljubljana, Slovenia Physics Department, Lancaster University, LA1 4YB, UK
    Physiol Meas 30:245-60. 2009
    ..To do so, we detected cardiac-induced pulse waves in skin microcirculation using laser Doppler flowmetry (LDF)...
  7. ncbi Pulp revascularization of replanted immature dog teeth after treatment with minocycline and doxycycline assessed by laser Doppler flowmetry, radiography, and histology
    Alessandra Luisa de Souza Ritter
    Department of Endodontics, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7450, USA
    Dent Traumatol 20:75-84. 2004
    ..Thirty-four immature teeth were selected from three young dogs. Baseline radiographs and laser Doppler flowmetry (LDF) readings were obtained...
  8. ncbi Comparison of near-infrared spectroscopy and laser Doppler flowmetry for detecting decreased hepatic inflow in the porcine liver
    Junichi Kaneko
    Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Invest Surg 22:268-74. 2009
    ..Near-infrared spectroscopy or laser Doppler flowmetry can be used to detect tissue oxygenation or microcirculation on the liver surface...
  9. ncbi Dose-dependent vasodilatory effects of acetylcholine and local warming on skin microcirculation
    Samuel Christen
    Division of Clinical Pathophysiology, University Hospital, Lausanne, Switzerland
    J Cardiovasc Pharmacol 44:659-64. 2004
    ..These techniques represent a unique means to investigate noninvasively the functional vasodilatory capacity of the skin microvasculature...
  10. ncbi Reproducibility and methodological issues of skin post-occlusive and thermal hyperemia assessed by single-point laser Doppler flowmetry
    M Roustit
    Inserm CIC3, Grenoble Clinical Research Center, Grenoble University Hospital, France
    Microvasc Res 79:102-8. 2010
    ..We also evaluated spatial reproducibility of both tests on the forearm. Finally, we assessed the influence of mental stress and room temperature variations on PORH and LTH...
  11. ncbi Vascular evaluation in laryngeal diseases: comparison between contact endoscopy and laser Doppler flowmetry
    Michihiko Sone
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Arch Otolaryngol Head Neck Surg 132:1371-4. 2006
    ..To determine the efficacies of 2 methods for evaluating vascular changes in laryngeal diseases...
  12. ncbi Low-frequency oscillations of the laser Doppler perfusion signal in human skin
    Per Kvandal
    Department of Intensive Care Medicine, Ulleval University Hospital, 0407 Oslo, Norway
    Microvasc Res 72:120-7. 2006
    ..Thus, other endothelial mechanisms, such as endothelium-derived hyperpolarizing factor (EDHF), might be involved in the regulation of this sixth frequency interval (0.005-0.0095 Hz)...
  13. ncbi Involvement of sympathetic nerve activity in skin blood flow oscillations in humans
    Torbjörn Söderström
    Department of Plastic and Reconstructive Surgery, Malmo University Hospital, S 205 02 Malmo, Sweden
    Am J Physiol Heart Circ Physiol 284:H1638-46. 2003
    ..02-0.05 hz...
  14. ncbi Robust flow measurement with multi-exposure speckle imaging
    Ashwin B Parthasarathy
    Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA
    Opt Express 16:1975-89. 2008
    ..We also show that the new speckle model used with the MESI instrument can maintain the linearity of relative flow measurements in the presence of static scatterers...
  15. ncbi Abnormal endothelium-dependent microvascular reactivity in recently preeclamptic women
    Judith Blaauw
    Department of Obstetrics and Gynecology, Groningen University Medical Centre, Groningen, The Netherlands
    Obstet Gynecol 105:626-32. 2005
    ....
  16. ncbi Role of nitric oxide in the vascular effects of local warming of the skin in humans
    D L Kellogg
    Geriatric Research, Education, and Clinical Center, Department of Veterans Affairs, South Texas Veterans Health Care System, University of Texas Health Science Center at San Antonio, 78284, USA
    J Appl Physiol (1985) 86:1185-90. 1999
    ..Thus NOS inhibition attenuated, and sodium nitroprusside restored, the cutaneous vasodilation induced by elevation of Tloc; therefore, the mechanism of cutaneous vasodilation by local warming requires NOS generation of NO...
  17. ncbi Clinical significance of tissue blood flow during esophagectomy by laser Doppler flowmetry
    Y Ikeda
    First Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan
    J Thorac Cardiovasc Surg 122:1101-6. 2001
    ..We sought to investigate the effect of tissue blood flow on the incidence of anastomotic leakage during esophagectomy...
  18. ncbi Measurement depth and volume in laser Doppler flowmetry
    Ingemar Fredriksson
    Linkoping University, Department of Biomedical Engineering, University Hospital, S 581 85 Linkoping, Sweden
    Microvasc Res 78:4-13. 2009
    A new method for estimating the measurement depth and volume in laser Doppler flowmetry (LDF) is presented. The method is based on Monte Carlo simulations of light propagation in tissue...
  19. ncbi Noninvasive measure of microvascular nitric oxide function in humans using very low-frequency cutaneous laser Doppler flow spectra
    Julian M Stewart
    New York Medical College, Valhalla, New York, USA
    Microcirculation 14:169-80. 2007
    While higher frequency oscillations (0.021-0.6 Hz) in cutaneous blood flow measured by laser Doppler flowmetry (LDF) relate to oscillations in blood pressure and sympathetic nerve activity, very low-frequency oscillations (VLF, 0.0095-0...
  20. ncbi Relationship between post-occlusive forearm skin reactive hyperaemia and vascular disease in patients with Type 2 diabetes--a novel index for detecting micro- and macrovascular dysfunction using laser Doppler flowmetry
    R Yamamoto-Suganuma
    Department of Internal Medicine, Koshigaya Hospital, Dokkyo, Medical University, Saitama, Japan
    Diabet Med 26:83-8. 2009
    ....
  21. ncbi Blunted vasodilatory responses in the cutaneous microcirculation of cigarette smokers
    Cyril Pellaton
    Division of Clinical Pathophysiology and Medical Teaching, University Hospital, Lausanne, Switzerland
    Am Heart J 144:269-74. 2002
    ..The present study was undertaken to investigate whether chronic smoking alters the vasodilatory capacity in the microcirculation...
  22. ncbi Functional laser Doppler flowmetry of the optic nerve: physiological aspects and clinical applications
    Charles E Riva
    Dipartimento di Discipline Chirurgiche, Rianomatorie e dei Trapianti Antonio Valsalva, Universita di Bologna, Bologna, Italy
    Prog Brain Res 173:149-63. 2008
    The present paper reviews the methodology and clinical results of recording, by laser Doppler flowmetry, the hemodynamic response of the optic nerve head elicited by visual stimulation...
  23. ncbi He-Ne laser effects on blood microcirculation during wound healing: a method of in vivo study through laser Doppler flowmetry
    Silvia Cristina Nunez
    Centro de Lasers e aplicacoes Instituto de Pesquisas Energéticas e Nucleares, IPEN CNEN SP, Sao Paulo, Brazil 05508 000
    Lasers Surg Med 35:363-8. 2004
    ..The aim of this study was to evaluate blood flow alterations in a wound healing model, using laser Doppler flowmetry (LDF) associated with a normalized perfusion parameter.
  24. ncbi Transcutaneous delivery of prostaglandin E1: in vitro and laser doppler flowmetry study
    M Foldvari
    College of Pharmacy and Nutrition and Departments of Pharmacology, Surgery, and Medical Imaging, University of Saskatchewan, Saskatoon, SK, Canada S7N 5C9
    J Pharm Sci 87:721-5. 1998
    ..and nonliposomal (oil/water cream) delivery systems] in vitro using diffusion cells and in vivo using laser doppler flowmetry, to aid in the development of a topically active preparation for the treatment of male sexual dysfunction...
  25. ncbi The effect of intranasal budesonide spray on mucosal blood flow measured with laser Doppler flowmetry
    A Cervin
    Department of Oto-Rhino-Laryngology, Head and Neck Surgery, University of Lund, S-221 85 Lund, Sweden
    Rhinology 39:13-6. 2001
    ..Blood flow was measured on the nasal septum with Laser Doppler flowmetry up to 20 min after administration...
  26. ncbi Optic nerve head blood flow using scanning laser Doppler flowmetry after laser in situ keratomileusis
    Akif Ozdamar
    Department of Ophthalmology, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey
    J Refract Surg 19:433-7. 2003
    ..To investigate ocular blood flow changes following laser in situ keratomileusis (LASIK) in myopic eyes...
  27. pmc Multifractality in the peripheral cardiovascular system from pointwise holder exponents of laser Doppler flowmetry signals
    Anne Humeau
    Groupe ISAIP ESAIP, Saint Barthélémy d Anjou, France
    Biophys J 93:L59-61. 2007
    We study the dynamics of skin laser Doppler flowmetry signals giving a peripheral view of the cardiovascular system...
  28. ncbi Quantitative estimates of angiogenic and anti-angiogenic activity by laser Doppler flowmetry (LDF) and near infra-red spectroscopy (NIRS)
    M Kragh
    Institute of Molecular Pathology, University of Copenhagen, 11 Frederik V Vej, DK-2100, Copenhagen, Denmark
    Eur J Cancer 37:924-9. 2001
    The use of laser Doppler flowmetry (LDF) and near-infra-red spectroscopy (NIRS) for non-invasive in vivo measurements of angiogenic and anti-angiogenic activity in nude mice was evaluated...
  29. ncbi A method using laser Doppler flowmetry to study intestinal and pancreatic perfusion during an acute intestinal ischaemic injury in rats with pancreatitis
    A R Phillips
    Pancreatitis Research Group, Department of Surgery, School of Biological Science, University of Auckland, New Zealand
    Eur Surg Res 33:361-9. 2001
    ..of intestinal ischaemia and 30 min of reperfusion in rodents with acute pancreatitis, a model utilizing laser Doppler flowmetry was developed...
  30. ncbi The role of laser Doppler flowmetry in assessing the viability of bone fragments in an open fracture
    D E Hinsley
    Biomedical Sciences, CBD Porton Down, Salisbury, Wiltshire SP4 OJQ, UK
    Injury 33:435-8. 2002
    ..This study evaluated the applicability of laser Doppler flowmetry for the objective evaluation of fracture fragment viability in an experimental open ballistic fracture ..
  31. pmc Monitoring blood flow to colorectal liver metastases using laser Doppler flowmetry: the effect of angiotensin II
    D M Hemingway
    University Department of Surgery, Glasgow Royal Infirmary, UK
    Br J Cancer 66:958-60. 1992
    ..Using intraoperative laser Doppler flowmetry (LDF) we have assessed the effect of intraarterial angiotensin II (AI) on tumour blood flow in ten ..
  32. ncbi Free flap monitoring using simultaneous non-invasive laser Doppler flowmetry and tissue spectrophotometry
    Frank Holzle
    Department of Oral and Maxillofacial Plastic Surgery, Knappschaftskrankenhaus Bochum Langendreer, Ruhr University Bochum, Germany
    J Craniomaxillofac Surg 34:25-33. 2006
    ..The aim of this study was to investigate the benefits of the tissue oxygen analysis system O(2)C for monitoring patients undergoing maxillofacial reconstruction with fasciocutaneous radial forearm flaps...
  33. ncbi Sympathetic and parasympathetic neuropathy are frequent in both type 1 and type 2 diabetic patients
    Carolin Freccero
    Department of Plastic and Reconstructive Surgery, Malmo University Hospital, S 20502 Malmo, Sweden
    Diabetes Care 27:2936-41. 2004
    ..The aim of this study was to evaluate the frequency of sympathetic versus parasympathetic neuropathy among type 1 and type 2 diabetic patients...
  34. ncbi Continual measurement of intramedullary blood perfusion with laser Doppler flowmetry in intact and ostectomized tibiae of rabbits
    Ch Hackenbroich
    Small Animal Clinic, University of Veterinary Medicine Hannover, Foundation, Bischofsholer Damm 15, Hannover, Germany
    Lab Anim 42:305-19. 2008
    ..have been no publications on the daily, continual measurement of intramedullary blood perfusion using laser Doppler flowmetry (LDF) in the conscious animal...
  35. ncbi Scanning laser Doppler flowmetry shows reduced retinal capillary blood flow in CADASIL
    Mika Harju
    Glaucoma Service, Department of Ophthalmology, Helsinki University Central Hospital, PL 220, 00029 HUS, Helsinki, Finland
    Stroke 35:2449-52. 2004
    ..A cross-sectional study was performed to examine the retinal vascular caliber and blood flow in CADASIL...
  36. ncbi Reproducibility of cutaneous microvascular function assessment using laser Doppler flowmetry and acetylcholine iontophoresis
    K A Brocx
    School of Psychology, Murdoch University, Perth, W A, Australia
    Skin Pharmacol Physiol 22:313-21. 2009
    ..To investigate the reproducibility of direct and axon-reflex vasodilator responses to increasing doses of acetylcholine administered transcutaneously by iontophoresis...
  37. ncbi Interrelations of laser doppler flowmetry and brain tissue oxygen pressure during ischemia and reperfusion induced by an experimental mass lesion
    R Burger
    Department of Neurological Surgery, University of Würzberg, Germany
    J Neurotrauma 16:1149-64. 1999
    The objective of this study was to assess interrelations between bilateral changes of cortical laser doppler flowmetry and intraparenchymal, subcortical partial tissue oxygen tension in the course of an experimental trauma...
  38. pmc Reduced arteriovenous shunting capacity after local heating and redistribution of baseline skin blood flow in type 2 diabetes assessed with velocity-resolved quantitative laser Doppler flowmetry
    Ingemar Fredriksson
    Division of Biomedical Instrumentation, Department of Biomedical Engineering, Linkoping University, Linkoping, Sweden
    Diabetes 59:1578-84. 2010
    ..To compare the microcirculatory velocity distribution in type 2 diabetic patients and nondiabetic control subjects at baseline and after local heating...
  39. ncbi Comparison of continuous wave Doppler ultrasound of the radial artery and laser Doppler flowmetry of the fingertips with sympathetic stimulation
    Bernhard M Eicke
    Dept of Neurology, University Clinic of Mainz, Langenbeckstr 1, 55101 Mainz, Germany
    J Neurol 251:958-62. 2004
    ..the power of both methods, this study was performed with simultaneous assessment of cw Doppler and laser Doppler flowmetry in volunteers...
  40. ncbi Assessment of oxygenation and perfusion in the tongue and oral mucosa by visible spectrophotometry and laser Doppler flowmetry in healthy subjects
    D B Singh
    University Hospital of North Durham, Durham, UK
    Adv Exp Med Biol 614:227-33. 2008
    Use of Visible Light Spectrophotometry (VLS) and Laser Doppler Flowmetry (LDF) is currently being studied by the authors to assess the viability of tissue margins in colon resection and to assess mucosal oxygenation in the colon...
  41. ncbi Laser Doppler flowmetry predicts occlusion but not tPA-mediated reperfusion success after rat embolic stroke
    Nils Henninger
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Exp Neurol 215:290-7. 2009
    b>Laser Doppler flowmetry (LDF) is increasingly used to assess adequate occlusion after embolic stroke (ES) in rats.
  42. ncbi Methodological issues in the assessment of skin microvascular endothelial function in humans
    Jean Luc Cracowski
    Department of Human Physiology, University of Oregon, OR 97403 1240, USA
    Trends Pharmacol Sci 27:503-8. 2006
    The study of microvascular function can be performed in humans using laser Doppler flowmetry of the skin. This technology lends itself to a wide range of applications for studying the endothelial function of skin blood vessels...
  43. ncbi The effects of general anesthesia on human skin microcirculation evaluated by wavelet transform
    Svein Aslak Landsverk
    Department of Anesthesiology, Ulleval University Hospital, Oslo, Norway
    Anesth Analg 105:1012-9, table of contents. 2007
    Time-frequency analysis of the laser Doppler flowmetry signal, using wavelet transform, shows periodic oscillations at five characteristic frequencies related to the heart (0.6-2 Hz), respiration (0.15-0...
  44. ncbi Laser Doppler imaging prediction of burn wound outcome in children
    A J A Holland
    Department of Academic Surgery, Division of Surgery, The Children s Hospital at Westmead, Royal Alexandra Hospital for Children, The University of Sydney, Locked Bag 4001, NSW 2145, Westmead, Australia
    Burns 28:11-7. 2002
    ..The LDI was also more specific; correctly diagnosing 96% of superficial partial thickness burns as opposed to 71% on clinical examination. Moderate degrees of movement did not appear to limit the accuracy of the scan...
  45. ncbi A two-probe laser Doppler flowmetry assessment as an exclusive diagnostic device in a long-term follow-up of traumatised teeth: a case report
    Herman Roeykens
    Department of Operative Dentistry and Endodontology, University of Ghent, Belgium
    Dent Traumatol 18:86-91. 2002
    The reliability of laser Doppler flowmetry in a two-probe assessment of pulpal blood flow is well known...
  46. ncbi Statins enhance postischemic hyperemia in the skin circulation of hypercholesterolemic patients: a monitoring test of endothelial dysfunction for clinical practice?
    Christian Binggeli
    Cardiovascular Center, Division of Cardiology, University Hospital, CH 8091 Zurich, Switzerland
    J Am Coll Cardiol 42:71-7. 2003
    The present study aims to investigate whether laser Doppler flowmetry can be used to monitor improvements in vascular function during statin therapy.
  47. ncbi A comparison of laser Doppler imaging with other measurement techniques to assess burn depth
    S J Hemington-Gorse
    Plastic Surgery, Countess of Chester Hospital, Chester, UK
    J Wound Care 14:151-3. 2005
    ..This article reviews the literature to determine the advantages of laser Doppler imaging...
  48. ncbi Nitric oxide synthase inhibition does not alter the reactive hyperemic response in the cutaneous circulation
    Brett J Wong
    Department of Exercise and Movement Science, University of Oregon, Eugene, OR 97403 1240, USA
    J Appl Physiol 95:504-10. 2003
    ..9126 +/- 1088% CVC(max. s) after a 15-min arterial occlusion. These data suggest that NO does not directly mediate reactive hyperemia and that NO is not produced in response to an increase in shear stress in the cutaneous circulation...
  49. ncbi Laser Doppler flowmetry detection of endothelial dysfunction in end-stage renal disease patients: correlation with cardiovascular risk
    A Kruger
    Department of Medicine, New York Medical College, Valhalla, New York 10595, USA
    Kidney Int 70:157-64. 2006
    ..We have recently adapted a noninvasive laser Doppler flowmetry (LDF) functional testing of endothelium-dependent microvascular reactivity and demonstrated that end-..
  50. ncbi Individuals at increased coronary heart disease risk are characterized by an impaired microvascular function in skin
    R G Ijzerman
    Department of Medicine, VU University Medical Center, De Blelelaan 1117, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Eur J Clin Invest 33:536-42. 2003
    ....
  51. ncbi Statins, skin, and the search for a test of endothelial function
    David S Celermajer
    J Am Coll Cardiol 42:78-80. 2003
  52. ncbi Spectral components of laser Doppler flowmetry signals recorded in healthy and type 1 diabetic subjects at rest and during a local and progressive cutaneous pressure application: scalogram analyses
    Anne Humeau
    Groupe ISAIP ESAIP, 18 rue du 8 mai 1945, BP 80022, 49180 Saint Barthelemy d Anjou Cedex, France
    Phys Med Biol 49:3957-70. 2004
    A significant transient increase in laser Doppler flowmetry (LDF) signals is observed in response to a local and progressive cutaneous pressure application in healthy subjects. This reflex may be impaired in diabetic patients...
  53. pmc Rho-kinase inhibition acutely augments blood flow in focal cerebral ischemia via endothelial mechanisms
    Hwa Kyoung Shin
    Department of Radiology, Stroke and Neurovascular Regulation Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 27:998-1009. 2007
    ..Therefore, rapid nontranscriptional upregulation of eNOS activity by small molecule inhibitors of Rho-kinase may be a viable therapeutic approach in acute stroke...
  54. ncbi Noninvasive interrogation of microvasculature for signs of endothelial dysfunction in patients with chronic renal failure
    Julian Stewart
    Division of Nephrology and Renal Research Institute, New York Medical College, Center for Pediatric Hypotension, Suite 618, Munger Pavilion, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 287:H2687-96. 2004
    ..Therefore, we used laser Doppler flowmetry (LDF) and scanned laser Doppler imaging (LDI) to quantify parameters of the postocclusion reactive ..
  55. ncbi S-transform applied to laser Doppler flowmetry reactive hyperemia signals
    Said Assous
    Groupe ISAIP ESAIP, Saint Barthélémy d Anjou, France
    IEEE Trans Biomed Eng 53:1032-7. 2006
    b>Laser Doppler flowmetry signals give information about many physiological activities of the cardiovascular system. The activities manifest themselves in rhythmic cycles...
  56. ncbi Effect of anesthesia on the signal intensity in tumors using BOLD-MRI: comparison with flow measurements by Laser Doppler flowmetry and oxygen measurements by luminescence-based probes
    Christine Baudelet
    Laboratory of Medicinal Chemistry and Radiopharmacy, Universite Catholique de Louvain, Brussels, Belgium
    Magn Reson Imaging 22:905-12. 2004
    ..Our results emphasize the need for careful monitoring of the effects of anesthesia when trying to identify new therapeutic approaches that are aimed at modulating tumor hemodynamics...
  57. ncbi Microcirculatory characteristics of acupuncture points obtained by laser Doppler flowmetry
    Hsin Hsiu
    Department of Electrical Engineering, Yuan Ze University, Taoyuan, Taiwan, Republic of China
    Physiol Meas 28:N77-86. 2007
    ..In this study we employed laser Doppler flowmetry (LDF) to extract the microcirculatory characteristics of acupoints and their surrounding tissues, and we ..
  58. ncbi Methods for evaluation of peripheral neurovascular dysfunction
    A I Vinik
    The Leonard Strelitz Diabetes Research Institutes, Department of Internal Medicine, Eastern Virginia Medical School, Norfolk 23510, USA
    Diabetes Technol Ther 3:29-50. 2001
    ..A combination of microdialysis and iontophoresis techniques can be useful in assessment of the pharmacokinetics of polar and nonpolar agents and the physiology and pathophysiology of the skin neurovascular system...
  59. ncbi Effects of permanent magnets on resting skin blood perfusion in healthy persons assessed by laser Doppler flowmetry and imaging
    H N Mayrovitz
    College of Medical Sciences, Department of Physiology, Nova Southeastern University, Ft Lauderdale, Florida 33328, USA
    Bioelectromagnetics 22:494-502. 2001
    ..Blood perfusion was measured on the middle finger dorsum by laser Doppler flowmetry (LDF) and on the index finger by laser Doppler imaging (LDI)...
  60. ncbi Laser Doppler flowmetry for monitoring traumatized teeth
    J Y Lee
    Department of Health Policy and Administration, University of North Carolina at Chapel Hill, 27599 7450, USA
    Dent Traumatol 17:231-5. 2001
    b>Laser Doppler Flowmetry (LDF) has been shown to be valuable in monitoring revascularization of immature incisors following severe dental trauma...
  61. ncbi Clazosentan, an endothelin receptor antagonist, prevents early hypoperfusion during the acute phase of massive experimental subarachnoid hemorrhage: a laser Doppler flowmetry study in rats
    Gerrit A Schubert
    Department of Neurosurgery, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
    J Neurosurg 109:1134-40. 2008
    ..The purpose of this study was to further determine the role of ET in the first minutes to hours after massive experimental SAH induced by prophylactic treatment with the ET receptor antagonist clazosentan...
  62. ncbi Measurement of microcirculation in the optic nerve head by laser speckle flowgraphy and scanning laser Doppler flowmetry
    K Yaoeda
    Department of Ophthalmology, Niigata University School of Medicine, Niigata, Japan
    Am J Ophthalmol 129:734-9. 2000
    To evaluate and compare blood flow measurements by laser speckle flowgraphy and scanning laser Doppler flowmetry in the optic nerve head of normal volunteers.
  63. ncbi Intrarenal blood flow distribution in hyperdynamic septic shock: Effect of norepinephrine
    David Di Giantomasso
    Department of Medicine, Melbourne University Austin and Repatriation Medical Centre, Heidelberg, Australia
    Crit Care Med 31:2509-13. 2003
    ..To measure changes in medullary and cortical renal blood flow during experimental hyperdynamic sepsis and the effect of subsequent norepinephrine infusion on such flows. DESIGN Experimental animal study...
  64. ncbi Spectral analysis of laser Doppler skin blood flow oscillations in human essential arterial hypertension
    Marco Rossi
    University of Pisa
    Microvasc Res 72:34-41. 2006
    ..Forearm skin perfusion was measured by laser Doppler flowmetry (LDF) in conventional perfusion units (PU) before and after ischemia in 20 middle-age newly diagnosed EHT ..
  65. ncbi Evaluation of laser Doppler flowmetry for measurement of capillary blood flow in the stomach wall of dogs during gastric dilatation-volvulus
    Eric Monnet
    Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Vet Surg 35:198-205. 2006
    To validate laser doppler flowmetry (LDF) for measurement of blood flow in the stomach wall of dogs with gastric dilatation-volvulus (GDV).
  66. ncbi Spatiotemporal quantification of cerebral blood flow during functional activation in rat somatosensory cortex using laser-speckle flowmetry
    Turgut Durduran
    Departments of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cereb Blood Flow Metab 24:518-25. 2004
    ....
  67. ncbi Validation of laser Doppler flowmetry coupled with intra-dermal injection for investigating effects of vasoactive agents on the skin microcirculation in man
    Stephen J Leslie
    Clinical Pharmacology Unit and Research Centre, The University of Edinburgh, Western General Hospital, EH4 2XU, Edinburgh, UK
    Eur J Clin Pharmacol 59:99-102. 2003
    To determine the reproducibility of laser Doppler flowmetry coupled with intra-dermal saline delivery.
  68. ncbi Simultaneous measurement of local cortical blood flow and tissue oxygen saturation by Near infra-red Laser Doppler flowmetry and remission spectroscopy in the pig brain
    B Walter
    Friedrich Schiller University, Jena, Germany
    Acta Neurochir Suppl 81:197-9. 2002
    ..85, n = 67). Although the problem of spatial variability remains to be solved, the combined use of NiLDF and RS allows continuous and non-invasive monitoring of changes of key parameters of oxygen metabolism within the cerebral cortex...
  69. ncbi Non-invasive assessment of endothelial function - relation between vasodilatory responses in skin microcirculation and brachial artery
    Jimmy Hansell
    Department of Women and Child Health, Huddinge University Hospital, Stockholm, Sweden
    Clin Physiol Funct Imaging 24:317-22. 2004
    ..To compare different non-invasive methods for determination of human endothelial function in peripheral circulation...
  70. ncbi Perfusion of the femoral head during surgical dislocation of the hip. Monitoring by laser Doppler flowmetry
    H P Nötzli
    Department of Orthopaedic Surgery, University of Zurich, Switzerland
    J Bone Joint Surg Br 84:300-4. 2002
    We used laser Doppler flowmetry (LDF) with a high energy (20 mW) laser to measure perfusion of the femoral head intraoperatively in 32 hips. The surgical procedure was joint debridement requiring dislocation or subluxation of the hip...
  71. ncbi Instrument-independent flux units for laser Doppler perfusion monitoring assessed in a multi-device study on the renal cortex
    A L Petoukhova
    Faculty of Applied Physics, Biophysical Techniques Group, University of Twente, P O Box 217, 7500 AE Enschede, The Netherlands
    Microvasc Res 66:83-90. 2003
    To investigate the feasibility of instrument-independent perfusion units for laser Doppler flowmetry, a comparison was performed of two commercial fiberoptic laser Doppler perfusion monitors measuring the same flux situation for two ..
  72. ncbi Wavelet analysis of blood flow dynamics: effect on the individual oscillatory components of iontophoresis with pharmacologically neutral electrolytes
    Mitja Veber
    Group of Nonlinear Dynamics and Synergetics, Faculty of Electrical Engineering, University of Ljubljana, Trzaska 25, 1000 Ljubljana, Slovenia
    Phys Med Biol 49:N111-7. 2004
    ..The blood flow rate can be recorded by laser Doppler flowmetry (LDF), its average value and the amplitudes of its oscillatory components being used to evaluate the ..
  73. ncbi No effects of acute hyperglycaemia and hyperinsulinaemia on skin microcirculation and endothelial markers in Type II diabetes mellitus
    P H N Oomen
    Department of Internal Medicine, Division of General Internal Medicine, University Hospital, Groningen, The Netherlands
    Scand J Clin Lab Invest 64:119-27. 2004
    ....
  74. ncbi Reduced vasodilatory response to methylnicotinate in schizophrenia as assessed by laser Doppler flowmetry
    Brian M Ross
    Ness Foundation, UHI Millennium Institute, Ness House, Dochfour Business Centre, Dochgarroch, Inverness, IV3 8GY, UK
    Eur Neuropsychopharmacol 14:191-7. 2004
    ..Blood flow was monitored using laser Doppler flowmetry. Vasodilatory response to 1 and 10 mM methyl nicotinate was markedly and significantly reduced in ..
  75. ncbi Monitoring cerebral perfusion using near-infrared spectroscopy and laser Doppler flowmetry
    J H G M Klaessens
    Clinical Physics Laboratory, University Children s Hospital Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Physiol Meas 24:N35-40. 2003
    ..This result shows the additional value of LDF when combined with NIRS, preferably in one instrument. Development of pulsed LDF for regional blood flow measurement is indicated...
  76. ncbi The blood flow to the femoral head/neck junction during resurfacing arthroplasty: a comparison of two approaches using Laser Doppler flowmetry
    H W Amarasekera
    1Clinical Sciences Institute University of Warwick Medical School, Clinical Sciences Building, University Hospital, Clifford Bridge Road, Coventry CV2 2DX, UK
    J Bone Joint Surg Br 90:442-5. 2008
    We used Laser Doppler flowmetry to measure the effect on the blood flow to the femoral head/neck junction of two surgical approaches during resurfacing arthroplasty...
  77. ncbi Carbonic anhydrases and mucosal vanilloid receptors help mediate the hyperemic response to luminal CO2 in rat duodenum
    Yasutada Akiba
    Department of Medicine, School of Medicine, University of California Los Angeles, USA
    Gastroenterology 131:142-52. 2006
    ..We examined the hyperemic response to elevated luminal PCO(2) in the duodenum of anesthetized rats luminally exposed to high CO(2) saline to help elucidate luminal acid-sensing mechanisms...
  78. ncbi Decreasing gut wall glucose as an early marker of impaired intestinal perfusion
    Vladimir Krejci
    Department of Anesthesiology, Inselspital, Bern, Switzerland
    Crit Care Med 34:2406-14. 2006
    ..The aim of this study was to assess the microcirculatory and metabolic consequences of reduced mesenteric blood flow...
  79. ncbi Assessing revascularization of avulsed permanent maxillary incisors by laser Doppler flowmetry
    Heinrich Strobl
    Department of Oral and Maxillofacial Surgery, University of Innsbruck, Austria
    J Am Dent Assoc 134:1597-603. 2003
    b>Laser Doppler flowmetry, or LDF, is a noninvasive method used to assess pulpal blood flow, or PBF. Dental avulsion is associated with loss of pulpal sensitivity...
  80. pmc Endothelial nitric oxide synthase control mechanisms in the cutaneous vasculature of humans in vivo
    Dean L Kellogg
    Division of Geriatrics and Gerontology, Univ of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Am J Physiol Heart Circ Physiol 295:H123-9. 2008
    ..05). We conclude that eNOS is predominantly responsible for NO generation in skin during responses to increased T(loc), but not during reflex responses to whole body heat stress...
  81. ncbi The effect of nitric oxide synthase and cyclooxygenase inhibition on cutaneous microvascular reactivity
    Helena Lenasi
    Institute of Physiology, School of Medicine, University of Ljubljana, Zaloska 4, Ljubljana, Slovenia
    Eur J Appl Physiol 103:719-26. 2008
    ..8 +/- 70.5% in control vs. 733.5 +/- 54.6% in the treated site). These findings indicate that NO- and PGI(2)-independent mechanism plays an important role in the regulation of blood flow in the human skin microcirculation...
  82. ncbi The lamp effect of laser Doppler flowmetry on teeth
    S Polat
    Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Cumhuriyet University, 58140 Sivas, Turkey
    J Oral Rehabil 32:844-8. 2005
    ..The camera removing the charge coupled device's infrared cut filter was used for imaging the laser Doppler flowmetry light during pulpal blood flow measurement...
  83. ncbi A comparison of two laser-based methods for determination of burn scar perfusion: laser Doppler versus laser speckle imaging
    C J Stewart
    McCaig Centre for Joint Injury and Arthritis Research, Department of Surgery, University of Calgary, 3330 Hospital Drive NW, Calgary, Alta, Canada T2N 4N1
    Burns 31:744-52. 2005
    ..We have evaluated the ability of the LSPI instrument in determining and monitoring burn scar perfusion over time and compared it with the LDI instrument as a standard...
  84. ncbi Spectral analysis of blood perfusion in the free latissimus dorsi myocutaneous flap and in normal skin
    Xudong Liu
    Department of Orthopaedic Surgery, Shanghai No 6 People s Hospital, Shanghai Jiao Tong University, Shanghai 200233, People s Republic of China
    Phys Med Biol 51:173-83. 2006
    ..of the cutaneous blood flow on the successful free flap, a wavelet transform was applied to the laser Doppler flowmetry (LDF) signals which were measured simultaneously on the surfaces of the free latissimus dorsi ..
  85. ncbi Effect of an 8-week resistance training program on cutaneous perfusion in type 2 diabetes
    Sheri R Colberg
    ESPER Department, Old Dominion University, Norfolk, VA 23529, USA
    Microvasc Res 71:121-7. 2006
    ....
  86. ncbi [Evaluation of sympathicolysis after continuous brachial plexus analgesia using laser Doppler flowmetry in patients suffering from CRPS I]
    G Gradl
    Chirurgische Klinik und Poliklinik, Abteilung für Unfall und Wiederherstellungschirurgie der Universität Rostock
    Anasthesiol Intensivmed Notfallmed Schmerzther 40:345-9. 2005
    ..The aim of this study was to evaluate continuous brachial plexus analgesia in terms of pain relief and sympathicolysis in patients suffering from CRPS I...
  87. ncbi Laser Doppler flowmetry is valid for measurement of cerebral blood flow autoregulation lower limit in rats
    Jan Tonnesen
    Neurobiology Research Unit, N9201, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Exp Physiol 90:349-55. 2005
    b>Laser Doppler flowmetry (LDF) is a recent technique that is increasingly being used to monitor relative changes in cerebral blood flow whereas the intra-arterial 133xenon injection technique is a well-established method for repeated ..
  88. ncbi Laser Doppler flowmetry in asymmetric glaucoma
    Andrew Lam
    Scheie Eye Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19114, USA
    Curr Eye Res 30:221-7. 2005
    ....
  89. ncbi Maximum skin hyperaemia induced by local heating: possible mechanisms
    Kim M Gooding
    Institute of Biomedical and Clinical Sciences, Peninsula Medical School, Exeter, UK
    J Vasc Res 43:270-7. 2006
    ..Interpretation of these findings is hampered by the lack of clarity of the mechanisms involved in the attainment of MH...
  90. ncbi Ethnic differences in skin microvascular function and their relation to cardiac target-organ damage
    William D Strain
    International Centre for Circulatory Health, Faculty of Medicine, Imperial College London at St Mary s, London, UK
    J Hypertens 23:133-40. 2005
    ..People of Black African descent have increased risks of vascular target-organ damage not explained by greater blood pressures...
  91. ncbi A critical evaluation of the clinimetrics of laser Doppler as a method of burn assessment in clinical practice
    Justin S Chatterjee
    Department of Burns and Plastic Surgery, Ninewells Hospital and Medical School, Dundee, Scotland, United Kingdom
    J Burn Care Res 27:123-30. 2006
    ..Until such time, laser Doppler should remain as a research tool...
  92. ncbi Effects of vacuum-assisted closure therapy on inguinal wound edge microvascular blood flow
    Angelica Wackenfors
    Department of Internal Medicine, Lund University Hospital, Lund, Sweden
    Wound Repair Regen 12:600-6. 2004
    ..A low negative pressure during treatment may be beneficial, especially in soft tissue, to minimize possible ischemic effects. Intermittent VAC therapy may further increase blood flow...
  93. ncbi Measurement of blood flow in the rotator cuff using laser Doppler flowmetry
    O Levy
    Reading Shoulder Unit, Royal Berkshire Hospital, Reading RG1 5AN, UK
    J Bone Joint Surg Br 90:893-8. 2008
    ..Blood flow was measured intra-operatively by laser Doppler flowmetry. We investigated six different zones of each rotator cuff during the arthroscopic examination of 56 ..
  94. ncbi Imaging cerebral blood flow through the intact rat skull with temporal laser speckle imaging
    Pengcheng Li
    Key Laboratory of Biomedical Photonics of Ministry of Education Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, China
    Opt Lett 31:1824-6. 2006
    ....
  95. ncbi Effects of diode laser therapy on blood flow in axial pattern flaps in the rat model
    J Kubota
    Department of Plastic and Reconstructive Surgery, Kyorin University School of Medicine, Mitaka City, Japan
    Lasers Med Sci 17:146-53. 2002
    ..One possible mechanism of modulation of the autonomic nervous system is discussed...
  96. ncbi Hemodynamic assessment of local anesthetic administration by laser Doppler flowmetry
    E M Fernieini
    School of Dental Medicine, University of Connecticut, 263 Farmington Ave, Farmington, CT 06030, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 91:526-30. 2001
    ..effects of local anesthetic administration with and without a vasoconstrictor were compared by using laser Doppler flowmetry. STUDY DESIGN: Seventeen people participated in a single study session in which they were given 2 ..
  97. pmc Direct measurement of acid permeation into rat oesophagus
    S Tanaka
    West Los Angeles Veterans Affairs Medical Centre, CURE Digestive Diseases Research Centre, Los Angeles, CA 90073, USA
    Gut 52:775-83. 2003
    ..A novel confocal microscopic technique was used in vitro to measure pH(int) from defined cellular sites in response to luminal and basolateral acidification...
  98. ncbi Regulation of human cutaneous circulation evaluated by laser Doppler flowmetry, iontophoresis, and spectral analysis: importance of nitric oxide and prostaglandines
    Per Kvandal
    Department of Anesthesiology, Ulleval University Hospital, 0407 Oslo, Norway
    Microvasc Res 65:160-71. 2003
    ..ACh) and the endothelium-independent vasodilator sodium nitroprusside (SNP) were recorded by laser Doppler flowmetry (LDF). We performed wavelet transforms of the measured signals...
  99. ncbi Laser Doppler imaging of burn scars: a comparison of wavelength and scanning methods
    Robert Bray
    Department of Surgery, McCaig Center for Joint Injury and Arthritis Research, 3330 Hospital Dr NW, University of Calgary, Calgary, Alta, Canada
    Burns 29:199-206. 2003
    ..We have evaluated two commercially available laser Doppler imagers for the perfusion measurement of normal and burn scar tissue...
  100. ncbi Dermal neurovascular dysfunction in type 2 diabetes
    A I Vinik
    Department of Medicine and Pathology/Anatomy/Neurobiology, the Strelitz Diabetes Research Institutes, Eastern Virginia Medical School, Norfolk, Virginia, USA
    Diabetes Care 24:1468-75. 2001
    ..CONCLUSIONS: These observations suggest that dermal neurovascular function is largely regulated by peripheral C-fiber neurons and that dysregulation may be a component of the metabolic syndrome associated with type 2 diabetes...
  101. ncbi Reproducibility and clinical application of a newly developed stabilized retinal laser Doppler instrument
    Akitoshi Yoshida
    Department of Ophthalmology, Asahikawa Medical College, Asahikawa, Japan
    Am J Ophthalmol 135:356-61. 2003
    ..To describe a newly developed stabilized retinal laser Doppler instrument, to report the reproducibility of retinal blood flow measurements, and to present examples of its clinical application...

Research Grants62

  1. Mechanisms of Vasovagal Syncope
    Julian M Stewart; Fiscal Year: 2013
    ..Our approach is two-fold: 1) We will use intradermal microdialysis and laser Doppler flowmetry (LDF) to delineate the microvascular mechanisms of NO modulation of noradrenergic neurotransmission free ..
  2. Vascular effects of dietary salt in humans with salt-resistant BP
    William B Farquhar; Fiscal Year: 2013
    ..conduit endothelial- dependent dilation and cutaneous vasodilation in response to local heating using laser Doppler flowmetry and intradermal microdialysis will be assessed in the forearm to evaluate the microvasculature...
  3. Role of TRP Channels in Environmental Irritant-Induced Headache
    Gerry S Oxford; Fiscal Year: 2013
    ..Our experiments will combine Laser Doppler flowmetry, measurements of CGRP release, fluorescence imaging of intracellular calcium, cellular electrophysiology, ..
  4. Local Vasoconstriction in Postural Tachycardia Syndrome
    Julian M Stewart; Fiscal Year: 2013
    ..LFP caused by Ang-II/oxidase induced oxidative stress? Experiments use intradermal microdialysis probes, laser Doppler flowmetry, and the NO-dependent local heating response to measure Ang-II and Ang-(1-7) in the skin, and to examine ..
  5. African and European Descent, Ocular Blood Flow and Glaucoma Progression
    Alon Harris; Fiscal Year: 2013
    ..retina tomography III, color Doppler imaging of the retrobulbar blood vessels, confocal scanning laser Doppler flowmetry of retinal capillaries, ocular perfusion pressure calculations, refraction, Pascal applanation (ocular ..
  6. Exercise training and cognitive and physical function in CKD
    Daniel E Weiner; Fiscal Year: 2013
    ..strength, and short physical performance battery;4) HRQoL (Short Form-36);5) Microvascular function using laser Doppler flowmetry;6) Inflammation (hs-CRP and IL-6) and vascular risk factors (lipids, BP, insulin resistance)...
  7. Exercise and Vascular Function in Chronic Kidney Disease
    David G Edwards; Fiscal Year: 2013
    ..conduit endothelial-dependent dilation and cutaneous vasodilation in response to local heating using laser Doppler flowmetry and intradermal microdialysis will be assessed in the forearm to evaluate the microvasculature...
  8. Effects of obstructive sleep apnea on cerebral circulation
    Robert M Bryan; Fiscal Year: 2013
    ..pressurized cerebral arteries and arterioles and measurement of CBF with autoradiographic techniques and laser Doppler flowmetry. Completion of these studies will move us toward a better understanding of the underlying mechanisms of ..
  9. Cerebrovascular mechanisms in methamphetamine-mediated exacerbation of neuroAIDS
    Stephen Dewhurst; Fiscal Year: 2012
    ..show that acute MA exposure results in a significant decline in CBF in wild-type mice, as measured by laser doppler flowmetry. Thus, our central hypothesis is that: MA disrupts cerebral blood flow and elicits cerebrovascular ..
  10. Mechanisms of Vascular Protection after Acute Stroke
    Susan C Fagan; Fiscal Year: 2013
    ..and hyperglycemic rat models of temporary cerebral ischemia, continuous BP monitoring via telemetry, laser Doppler flowmetry, BP lowering and pharmacologic MMP and oxidative stress modulation...
  11. Phytoestrogens, insulin resistance and endothelial function
    NINA STACHENFELD; Fiscal Year: 2012
    ..and genistein directly into the skin using microdialysis while measuring microvascular blood flow with laser Doppler flowmetry. Our first Aim will use dose-response curves to determine the 172-estradiol and genistein effects on the ..
  12. TRPV1 mediation of local vasoconstrictor reflexes in spinal cord injured humans
    Dean L Kellogg; Fiscal Year: 2013
    ..Local anesthesia will be by EMLA and TRPV1 receptor blockade by local administration of capsazepine. Responses will be recorded by laser-Doppler flowmetry. ..
  13. Control of Cerebral Blood Flow by KCa2 and KCa3
    Robert M Bryan; Fiscal Year: 2013
    ..Increases in CBF will be measured from the cortical surface using laser Doppler flowmetry following direct stimulation of IKCa and SKCa channels or indirectly through ATP, an agonist for ..
  14. Muscle Perfusion and Protein Metabolism in Elderly
    Melinda Sheffield Moore; Fiscal Year: 2009
    ..e. laser Doppler flowmetry) and microvascular perfusion (i.e. capillary flow and volume) in skeletal muscle...
  15. Neurovascular Structure and Function, Diabetic Neuropathy and Wound Healing
    Alexandra Hovaguimian; Fiscal Year: 2012
    ..acetylcholine iontophoresis to elicit the vasomotor axon-reflex and blood flow will be measured using laser doppler flowmetry. Wound healing will be quantified with serial high-resolution magnified digital photography measuring ..
  16. Osteocyte reaction to decreased bone fluid flow
    Shijing Qiu; Fiscal Year: 2003
    ..The spatial relationship between osteoclastic resorption and osteocyte degeneration will be determined in the sections with toluidine blue and TUNEL stain. ..
  17. Development of fMRI Methods for Neuropharmacology
    Shi Jiang Li; Fiscal Year: 2007
    ..We will also conduct Laser Doppler Flowmetry and EEG experiments to validate this biophysical model.
  18. NITRIC OXIDE AND MEDIATING PRESSURE NATRIURESIS
    DEWAN MAJID; Fiscal Year: 2000
    ..The result of this study may clarify the mechanisms responsible for this pressure-natriuresis phenomenon and may be helpful in developing effective treatments for hypertension. ..
  19. Brain serotonin and angiotensin II systems in migraine
    JOSE TERRON; Fiscal Year: 2007
    ..5-HT content will be measured by HPLC in brain homogenates. ..
  20. Local Warming: Effects on Wound Infection and Healing
    JoAnne Whitney; Fiscal Year: 2007
    ..2.3. Perfusion (BF) in the surgical incision on postoperative days 3, 5 and 9 using Laser Doppler Flowmetry (LDF).
  21. Cannabinoid Receptors and Cerebrovascular Function
    Cecilia Hillard; Fiscal Year: 2006
    ..to measure endocannabinoids and the in vivo significance of these findings will be explored using laser Doppler flowmetry. The specific aims of this proposal are: (1) to characterize the role of the CB1 receptor in cerebral ..
  22. AUTONOMIC CONTROL OF OCULAR BLOOD FLOW
    Michael Koss; Fiscal Year: 1999
    ....
  23. CELLULAR CONTROL MECHANISMS OF CEREBROVASCULAR TONE
    David Harder; Fiscal Year: 1999
    ..It is essential to delineate the mechanisms which control normal cerebral blood flow before we can fully understand the etiology of cerebral vascular pathologies such as stroke and impaired cerebral blood flow during ischemia. ..
  24. OTIC PROBE FOR NEUROCOCHLEAR INTRAOPERATIVE MONITORING
    Rafael Delgado; Fiscal Year: 2003
    ..abstract_text> ..
  25. Cerebral Amyloid Angiopathy, Vascular Dysfunction & Ischemic Brain Injury
    Gregory J Zipfel; Fiscal Year: 2010
    ..Results from the proposed research project may lead to new treatment options for those individuals with CAA, Alzheimer's Disease, or both disorders. ..
  26. DOPPLER ULTRASOUND COCHLEAR BLOODFLOW MONITOR
    Arne Voie; Fiscal Year: 2000
    ..This device will help determine appropriate therapy for patients in both venues. ..
  27. ESTROGEN AND CEREBRAL VASODILATION
    Dale Pelligrino; Fiscal Year: 2000
    ..These results should provide important information about the cerebrovascular influences of estrogen. ..
  28. Retinal imaging tests for microvascular functions
    George King; Fiscal Year: 2003
    ..QST) and nerve axonal reflex (NAR) for measuring sensory fiber abnormalities and skin blood flow by laser Doppler flowmetry. The specific aims for this grant are: 1) to determine in control and non-diabetic subjects from 18-35 ..
  29. A New Device for Monitoring Diabetic Microcirculation
    CORNELIS DROST; Fiscal Year: 2003
    ..I we will build prototype hardware to demonstrate feasibility of our novel approach to high-resolution laser Doppler flowmetry under low flow conditions, and spectral analysis software optimized for low-frequency skin perfusion ..
  30. BLOOD FLOW AND METABOLIC CONTROLS IN THE FETAL BRAIN
    Gordon Power; Fiscal Year: 2005
    ..In the last two years, we have successfully adapted laser Doppler flowmetry to measure cerebral blood flow in the chronically prepared, near-term fetal sheep...
  31. MICROVASCULAR MONITORING USING OPTICAL TECHNOLOGY
    J Nelson; Fiscal Year: 2001
    ..Furthermore, in contrast to laser Doppler flowmetry, the overall ODT signal due to moving red blood cells (RBC) is almost entirely due to the Doppler shifted ..
  32. The hemodynamic response to neural activity in brain
    John Mayhew; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): The research will use optical imaging spectroscopy (OIS), laser Doppler flowmetry (LDF) and functional magnetic imaging (fMRI) to study the relationship between the hemodynamic responses to changes ..
  33. CONFOCAL LASER DOPPLER FLOWMETRY IN THE OPTIC NERVE
    ANDREAS DREHER; Fiscal Year: 1999
    ..Such an instrument would be very useful in the clinical areas of early detection and monitoring of disease processes and their treatment. ..
  34. MICROVASCULAR MONITORING USING OPTICAL TECHNOLOGY
    J Nelson; Fiscal Year: 2003
    ..Furthermore, in contrast to laser Doppler flowmetry, the overall ODT signal due to moving red blood cells (RBC) is almost entirely due to the Doppler shifted ..
  35. P450 EICOSANOIDS, CELL CALCIUM AND VASCULAR FUNCTION
    EARL ELLIS; Fiscal Year: 2002
    ..These studies will provide important basic information relevant to the role of P450 eicosanoids in the regulation of intra- and intercellular relationships of many cell types, including those which control brain blood flow. ..
  36. MECHANISMS OF CUTANEOUS ACTIVE VASODILATION
    Dean Kellogg; Fiscal Year: 2008
    ..In addition, intradermal microdialysis will be combined with measurements of bioavailable NO by NO-selective amperometric electrode to define further how the NO system functions in cutaneous active vasodilation. ..
  37. REAL TIME HIGH RESOLUTION IMAGING OF MICROVASCULATURE
    Thomas Milner; Fiscal Year: 2000
    Adapted from the applicant's abstract): ODT combines laser Doppler flowmetry (LDF) with optical coherence tomography to obtain high resolution tomographic images of static and moving constituents in highly scattering biological tissues...
  38. MICROELECTRODE AND BLOOD FLOW STUDIES IN OPTIC NERVE
    DONALD BUERK; Fiscal Year: 2000
    ..quenching will be incorporated into the existing microscope-based infrared laser system for laser Doppler flowmetry (LDF). This will allow simultaneous NO, PO2 and relative red blood cell flux (blood flow) to be measured...
  39. Micro-HemoDynamic Oximeter
    GREGORY ZELTSER; Fiscal Year: 2005
    ..in both venous and arterial blood and blood flow, based on a combination of reflectance oximetry and laser Doppler flowmetry (LDF)...
  40. Circulatory Dysfunction in Chronic Fatigue Syndrome
    Julian Stewart; Fiscal Year: 2004
    ....
  41. Detecting Endothelial Dysfunction in Renal Failure
    Julian Stewart; Fiscal Year: 2007
    ..These data will form the basis of future noninvasive prognostic testing and treatment of patients at risk for ECD and can provide a means to follow treatment modalities. [unreadable] [unreadable] [unreadable]..
  42. OCULAR HEMODYNAMICS IN GLAUCOMA
    Juan Grunwald; Fiscal Year: 2001
    ..To achieve this goal we will use laser Doppler flowmetry, a non-invasive technique that provides relative measurements of blood velocity, blood volume and blood ..
  43. ENHANCED THERAPY RESPONSE IN OSTEOSARCOMA
    GENE DIRESTA; Fiscal Year: 2001
    ..The MSKCC Therapeutics faculty believes that the ALS, if successful in this model, has promise as an adjunct for limb salvage procedures and in the treatment of many unresectable or disfiguring tumors. ..
  44. Skin Cooling to Improve Orthostatic Tolerance
    CRAIG CRANDALL; Fiscal Year: 2005
    ....
  45. Fetal and Neonatal Hemodynamics in IUGR Pregnancies
    Henry Galan; Fiscal Year: 2006
    ..abstract_text> ..
  46. Brain K+ Dynamics, BBB Breakdown & Hemorrhagic Transformation in Ischemic Stroke
    Stephen Jones; Fiscal Year: 2009
    ..This proposal's investigation of the relation of BBB breakdown to HT could lead directly to additional di- agnostic and therapeutic advances in the assessment and management of acute ischemic stroke. ..
  47. Retinopathy in Chronic Renal Insufficiency
    Juan E Grunwald; Fiscal Year: 2010
    ....
  48. Choroidal circulation in age related macular degeneration
    Juan Grunwald; Fiscal Year: 2008
    ..The main aim of these studies is to use the state-of-the-art, non-invasive technique of laser Doppler flowmetry to investigate whether choroidal blood flow and its regulation are abnormal in AMD...
  49. Neural and non-neural modulators of skin blood flow and sweating in humans
    CRAIG CRANDALL; Fiscal Year: 2009
    ..e. diabetes, heart failure, etc) and non-disease (i.e. aging) conditions. ..
  50. CONTROL OF MICROVASCULAR TONE IN TRAUMATIC BRAIN INJURY
    Jose Rafols; Fiscal Year: 2008
    ..unreadable]..
  51. TISSUE ENGINEERING IN THE INNER EAR
    JOSEF MILLER; Fiscal Year: 2005
    ....
  52. MRI MEASUREMENT OF RELATIVE CMR02-- VALIDATION USING PET
    JOSEPH MANDEVILLE; Fiscal Year: 2001
    ..Successful completion of the proposed studies will establish, a new tool for assessment of cerebral functional physiology and preface the application of these techniques to cerebral pathology. ..
  53. IMAGING OF INTRACRANIAL HEMATOMAS BY DIFFUSE TOMOGRAPHY
    David Boas; Fiscal Year: 2002
    ....
  54. ACTIVE THROMBOSIS, THROMBOLYSIS, AND STROKE OUTCOME
    Brant Watson; Fiscal Year: 2003
    ..Outcome at 3 days, monitored by histological evaluation of regions of frank and incomplete infarction, will be correlated with the time course of reperfusion-inducing treatments and associated molecular changes. ..
  55. Standards of Scientific Conduct
    Michael Kalichman; Fiscal Year: 2008
    ..Effective teaching about standards of the [unreadable] responsible conduct of research will help to promote public health by fostering integrity in the conduct of biomedical research. [unreadable] [unreadable] [unreadable]..
  56. REPERFUSION EFFECTS ON CEREBRAL ARTERY FUNCTION
    Marilyn Cipolla; Fiscal Year: 2003
    ..Therefore, Aim 3 will investigate the effects of two types of thrombolytic agents (tissue-type and urokinase) on cerebral artery function, including myogenic processes. ..
  57. Cerebral Arteriole Function during Hyperglycemic Stroke
    Marilyn Cipolla; Fiscal Year: 2009
    ....
  58. Neuropathology and Pathogenesis of Huntington's Disease
    Anton Reiner; Fiscal Year: 2008
    ..abstract_text> ..
  59. Supplemental Oxygen for Hypoxia-Related Retinal Deseases
    Quan Nguyen; Fiscal Year: 2005
    ....
  60. Neuroprotective Mechanisms of Neuroglobin in Stroke
    Xiaoying Wang; Fiscal Year: 2010
    ..These proposed experiments should provide new insight into how Ngb protects neurons from hypoxia/ischemia and may ultimately lead to novel therapeutic strategies for the acute treatment of stroke. ..
  61. INTERVENTIONS TO PREVENT NOISE INDUCED HEARING LOSS
    JOSEF MILLER; Fiscal Year: 2007
    ..We will also determine if reduced blood flow potentiates NIHL, in vivo. These studies will define new interventions and synergies at sites along the apoptotic pathway to optimize the prevention of NIHL. ..