rheology

Summary

Summary: The study of the deformation and flow of matter, usually liquids or fluids, and of the plastic flow of solids. The concept covers consistency, dilatancy, liquefaction, resistance to flow, shearing, thixotrophy, and VISCOSITY.

Top Publications

  1. ncbi Rheology of gastric mucin exhibits a pH-dependent sol-gel transition
    Jonathan P Celli
    Department of Physics, Boston University, Boston, Massachusetts 02215, USA
    Biomacromolecules 8:1580-6. 2007
  2. ncbi Sickle red cell microrheology and sickle blood rheology
    Samir K Ballas
    Department of Medicine, Cardeza Foundation for Hematologic Research, Jefferson Medical College, Philadelphia, Pennsylvania, USA
    Microcirculation 11:209-25. 2004
  3. ncbi The rheology of liquids: a comparison of clinicians' subjective impressions and objective measurement
    Catriona M Steele
    Oral Dynamics Laboratory, Graduate Department of Speech Language Pathology, University of Toronto, Toronto, Ontario, Canada
    Dysphagia 18:182-95. 2003
  4. ncbi Compliant model of a coupled sequential coronary arterial bypass graft: effects of vessel wall elasticity and non-Newtonian rheology on blood flow regime and hemodynamic parameters distribution
    Foad Kabinejadian
    School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore
    Med Eng Phys 34:860-72. 2012
  5. ncbi Rheological characterization of hyaluronic acid derivatives as injectable materials toward nucleus pulposus regeneration
    Antonio Gloria
    Institute of Composite and Biomedical Materials, National Research Council, P le Tecchio 80, 80125, Naples, Italy
    J Biomater Appl 26:745-59. 2012
  6. ncbi Rheological properties of the vitreous and the role of hyaluronic acid
    Charles S Nickerson
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Chemical Engineering 210 41, Pasadena, CA 91125, USA
    J Biomech 41:1840-6. 2008
  7. ncbi Nonequilibrium mechanics of active cytoskeletal networks
    Daisuke Mizuno
    Department of Physics and Astronomy, Vrije Universiteit, 1081HV Amsterdam, Netherlands
    Science 315:370-3. 2007
  8. ncbi Rheology of heterotypic collagen networks
    Izabela K Piechocka
    Biological Soft Matter Group, FOM Institute AMOLF, Science Park 104, 1098 XG Amsterdam, The Netherlands
    Biomacromolecules 12:2797-805. 2011
  9. ncbi Wake structure and wing kinematics: the flight of the lesser dog-faced fruit bat, Cynopterus brachyotis
    Tatjana Y Hubel
    Division of Engineering, Brown University, Providence RI 02912, USA
    J Exp Biol 213:3427-40. 2010
  10. pmc Vaginal delivery of the recombinant HIV-1 clade-C trimeric gp140 envelope protein CN54gp140 within novel rheologically structured vehicles elicits specific immune responses
    Rhonda M Curran
    The School of Pharmacy, The Queen s University of Belfast, Belfast, BT9 7BL, Northern Ireland, UK
    Vaccine 27:6791-8. 2009

Detail Information

Publications328 found, 100 shown here

  1. ncbi Rheology of gastric mucin exhibits a pH-dependent sol-gel transition
    Jonathan P Celli
    Department of Physics, Boston University, Boston, Massachusetts 02215, USA
    Biomacromolecules 8:1580-6. 2007
    ..Bulk rheology measurements in the linear viscoelastic regime show that gastric mucin undergoes a pH-dependent sol-gel ..
  2. ncbi Sickle red cell microrheology and sickle blood rheology
    Samir K Ballas
    Department of Medicine, Cardeza Foundation for Hematologic Research, Jefferson Medical College, Philadelphia, Pennsylvania, USA
    Microcirculation 11:209-25. 2004
    ..Cellular dehydration, changes in sickle red blood cell rheology, adhesion of sickle red cells to vascular endothelium, inflammatory response, and tissue injury are some of the ..
  3. ncbi The rheology of liquids: a comparison of clinicians' subjective impressions and objective measurement
    Catriona M Steele
    Oral Dynamics Laboratory, Graduate Department of Speech Language Pathology, University of Toronto, Toronto, Ontario, Canada
    Dysphagia 18:182-95. 2003
    ..Physical sampling of these two products enabled clinicians to reliably perceive relative viscosity and density differences between the nectar- and honey-thick items...
  4. ncbi Compliant model of a coupled sequential coronary arterial bypass graft: effects of vessel wall elasticity and non-Newtonian rheology on blood flow regime and hemodynamic parameters distribution
    Foad Kabinejadian
    School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore
    Med Eng Phys 34:860-72. 2012
    ..present study has been carried out in order to (i) investigate the effects of wall compliance and non-Newtonian rheology on the local flow field and hemodynamic parameters distribution, and (ii) verify the advantages of the CABG ..
  5. ncbi Rheological characterization of hyaluronic acid derivatives as injectable materials toward nucleus pulposus regeneration
    Antonio Gloria
    Institute of Composite and Biomedical Materials, National Research Council, P le Tecchio 80, 80125, Naples, Italy
    J Biomater Appl 26:745-59. 2012
    ..Both HA derivatives showed a 'gel-like' rheological behavior similar to the native NP tissue and this behavior was not altered by injection...
  6. ncbi Rheological properties of the vitreous and the role of hyaluronic acid
    Charles S Nickerson
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Chemical Engineering 210 41, Pasadena, CA 91125, USA
    J Biomech 41:1840-6. 2008
    ..We hypothesize that hyaluronan plays a role in sustaining the "internal tension" by Donnan swelling...
  7. ncbi Nonequilibrium mechanics of active cytoskeletal networks
    Daisuke Mizuno
    Department of Physics and Astronomy, Vrije Universiteit, 1081HV Amsterdam, Netherlands
    Science 315:370-3. 2007
    ..We present a quantitative theoretical model connecting the large-scale properties of this active gel to molecular force generation...
  8. ncbi Rheology of heterotypic collagen networks
    Izabela K Piechocka
    Biological Soft Matter Group, FOM Institute AMOLF, Science Park 104, 1098 XG Amsterdam, The Netherlands
    Biomacromolecules 12:2797-805. 2011
    ..Here we investigate the influence of collagen composition on the structure and rheology of networks of purified collagen I and V, combining fluorescence and atomic force microscopy, turbidimetry, and ..
  9. ncbi Wake structure and wing kinematics: the flight of the lesser dog-faced fruit bat, Cynopterus brachyotis
    Tatjana Y Hubel
    Division of Engineering, Brown University, Providence RI 02912, USA
    J Exp Biol 213:3427-40. 2010
    ..We also investigated the degree of consistency within trials and looked at individual variation in flight parameters, and found distinct differences between individuals as well as within individuals...
  10. pmc Vaginal delivery of the recombinant HIV-1 clade-C trimeric gp140 envelope protein CN54gp140 within novel rheologically structured vehicles elicits specific immune responses
    Rhonda M Curran
    The School of Pharmacy, The Queen s University of Belfast, Belfast, BT9 7BL, Northern Ireland, UK
    Vaccine 27:6791-8. 2009
    ..Vaginal administration to rabbits induced specific serum IgG, and IgG and IgA in genital tract secretions. The RSVs are a viable delivery modality for vaginal immunization...
  11. pmc Rheology and confocal reflectance microscopy as probes of mechanical properties and structure during collagen and collagen/hyaluronan self-assembly
    Ya li Yang
    Department of Chemistry, Columbia University, New York, New York 10027, USA
    Biophys J 96:1566-85. 2009
    ..work, the gelation of three-dimensional collagen and collagen/hyaluronan (HA) composites is studied by time sweep rheology and time lapse confocal reflectance microscopy (CRM)...
  12. pmc Measurement of local viscoelasticity and forces in living cells by magnetic tweezers
    A R Bausch
    Physik Department E22 Biophysics group, Technische Universität M unchen, D 85748 Garching
    Biophys J 76:573-9. 1999
    ..Measuring the bead velocity parallel and perpendicular to the applied force showed that local active forces on the beads varied from 50 to 900 pN...
  13. ncbi The cell as a material
    Karen E Kasza
    Department of Physics and DEAS, Harvard University, Cambridge, MA 02138, USA
    Curr Opin Cell Biol 19:101-7. 2007
    ..These networks are highly nonlinear, with an elastic modulus that depends sensitively on applied stress. Theories can account for some of the measured properties, but a complete model remains elusive...
  14. ncbi Modeling passive mechanical interaction between aqueous humor and iris
    J J Heys
    Department of Chemical Engineering, University of Colorado, Boulder 80309-0424, USA
    J Biomech Eng 123:540-7. 2001
    ..The results compare favorably with clinical observations, supporting the hypothesis that passive iris deformation can produce the iris contours observed using ultrasound biomicroscopy...
  15. ncbi Structural deformation of bacterial biofilms caused by short-term fluctuations in fluid shear: an in situ investigation of biofilm rheology
    P Stoodley
    University of Exeter, Department of Biological Sciences, Hatherly Laboratories, Exeter, Devon EX4 4PS, UK
    Biotechnol Bioeng 65:83-92. 1999
    The physical properties (rheology) of biofilms will determine the shape and mechanical stability of the biofilm structure and consequently affect both mass transfer and detachment processes...
  16. ncbi "Whither flows the fluid in bone?" An osteocyte's perspective
    Melissa L Knothe Tate
    Department of Biomedical Engineering, ND 20, The Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Biomech 36:1409-24. 2003
    ....
  17. pmc Noninvasive cardiac flow assessment using high speed magnetic resonance fluid motion tracking
    Kelvin Kian Loong Wong
    Centre for Biomedical Engineering and School of Electrical and Electronic Engineering, University of Adelaide, Adelaide, South Australia
    PLoS ONE 4:e5688. 2009
    ....
  18. ncbi Effect of tea polyphenols on the dilational rheology of human whole saliva (HWS): part 2, polyphenols-HWS interaction
    Damiano Rossetti
    Unilever R and D Discover, Colworth Science Park, Sharnbrook, MK44 1LQ, UK
    Colloids Surf B Biointerfaces 110:474-9. 2013
    ..Using interfacial dilational rheology characterisation, we measure the variation in surface elasticity of a pre-adsorbed salivary film after exposure ..
  19. ncbi High frequency viscoelastic behaviour of low molecular weight hyaluronic acid water solutions
    Sabato Fusco
    Interdisciplinary Research Centre on Biomaterials CRIB and Department of Materials and Production Engineering, University of Naples Federico II, Naples, Italy
    Biorheology 44:403-18. 2007
    ....
  20. pmc Non-overlapping functions for Pyk2 and FAK in osteoblasts during fluid shear stress-induced mechanotransduction
    Suzanne R L Young
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
    PLoS ONE 6:e16026. 2011
    ..We determined that both methods of generating FF induced similar responses in both primary calvarial osteoblasts and immortalized calvarial osteoblasts...
  21. ncbi Spatial and temporal resolution of shear in an orbiting petri dish
    Jonathan Michael D Thomas
    Department of Chemical Engineering, University of Louisville, Louisville, KY 40292, USA
    Biotechnol Prog 27:460-5. 2011
    ....
  22. ncbi Desmin and vimentin intermediate filament networks: their viscoelastic properties investigated by mechanical rheometry
    Michael Schopferer
    Institute of Mechanical Process Engineering and Mechanics, University of Karlsruhe, 76131 Karlsruhe, Germany
    J Mol Biol 388:133-43. 2009
    ..These findings indicate that both IFs exhibit distinct mechanical properties that are adapted to their respective cellular surroundings [i.e., myocytes (desmin) and fibroblasts (vimentin)]...
  23. ncbi Rheological properties of synovial fluids
    H Fam
    Human Mobility Research Centre, Queen s University, Kingston General Hospital, Kingston, ON, Canada
    Biorheology 44:59-74. 2007
    ..Given its importance in the rheology of synovial fluid, an overview of the structure and rheology of HA (hyaluronic acid) is presented first...
  24. ncbi Visualization of irrigation fluid flow and calculation of its velocity distribution in the anterior chamber by particle image velocimetry
    Yuichi Kaji
    Department of Ophthalmology, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki, Japan
    Graefes Arch Clin Exp Ophthalmol 250:1023-7. 2012
    ..To visualize irrigation fluid flow and calculate its velocity distribution in the anterior chamber during phacoemulsification by particle image velocimetry...
  25. pmc Microfluidic enhancement of intramedullary pressure increases interstitial fluid flow and inhibits bone loss in hindlimb suspended mice
    Ronald Y Kwon
    La Jolla Bioengineering Institute, La Jolla, CA, USA
    J Bone Miner Res 25:1798-807. 2010
    ....
  26. pmc The role of lubricin in the mechanical behavior of synovial fluid
    G D Jay
    Division of Engineering and Department of Emergency Medicine, Brown University, Providence, RI 02912, USA
    Proc Natl Acad Sci U S A 104:6194-9. 2007
    Synovial fluid is a semidilute hyaluronate (HA) polymer solution, the rheology of which depends on HA-protein interactions, and lubricin is a HA-binding protein found in synovial fluid and at cartilage surfaces, where it contributes to ..
  27. ncbi Effect of concentration and molecular weight on the rheology of hyaluronic acid/bovine calf serum solutions
    H Fam
    Human Mobility Research Centre, Department of Chemical Engineering, Queen s University, Kingston General Hospital, Kingston, ON, Canada
    Biorheology 46:31-43. 2009
    ..The relevance of these results in the context of appropriate selection of a lubricating environment that mimics physiological conditions is discussed...
  28. pmc Shear stress induces osteogenic differentiation of human mesenchymal stem cells
    Gregory Yourek
    Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL 60612, USA
    Regen Med 5:713-24. 2010
    ..To determine whether fluid flow-induced shear stress affects the differentiation of bone marrow-derived human mesenchymal stem cells (hMSCs) into osteogenic cells...
  29. ncbi Irrigant flow within a prepared root canal using various flow rates: a Computational Fluid Dynamics study
    C Boutsioukis
    Department of Endodontology, Dental School, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Int Endod J 42:144-55. 2009
    ..To study using computer simulation the effect of irrigant flow rate on the flow pattern within a prepared root canal, during final irrigation with a syringe and needle...
  30. ncbi Direct measurement of the flow field around swimming microorganisms
    Knut Drescher
    Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge CB3 0WA, United Kingdom
    Phys Rev Lett 105:168101. 2010
    Swimming microorganisms create flows that influence their mutual interactions and modify the rheology of their suspensions...
  31. ncbi Oscillatory flows induced by microorganisms swimming in two dimensions
    Jeffrey S Guasto
    Department of Physics, Haverford College, Haverford, Pennsylvania 19041, USA
    Phys Rev Lett 105:168102. 2010
    ..The instantaneous mechanical power generated by the cells is measured from the velocity fields and peaks at 15 fW. The dissipation per cycle is more than 4 times what steady swimming would require...
  32. ncbi Micro-PIV measurements of blood flow in extraembryonic blood vessels of chicken embryos
    Jung Yeop Lee
    Department of Mechanical Engineering, Pohang University of Science and Technology, San 31, Hyoja Dong, Pohang, 790 784, Korea
    Physiol Meas 28:1149-62. 2007
    ..The measurement technique used here was useful in analyzing the hemodynamic characteristics of in vivo blood flow in chicken embryos...
  33. pmc A continuous-binding cross-linker model for passive airway smooth muscle
    Graham M Donovan
    Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand
    Biophys J 99:3164-71. 2010
    ..Furthermore, experiments in noncontractile tissue show qualitatively similar behavior, suggesting support for the protein-filament theory as a biomechanical basis for the behavior...
  34. ncbi Echocardiographic particle image velocimetry: a novel technique for quantification of left ventricular blood vorticity pattern
    Arash Kheradvar
    University of South Carolina, Columbia, SC 29208, USA
    J Am Soc Echocardiogr 23:86-94. 2010
    ..In addition, its capability was assessed in the clinical in vivo setting to obtain the ventricular flow pattern in normal subjects, in patients with dilated cardiomyopathy, and in patients with mechanical and bioprosthetic mitral valves...
  35. pmc Altering mucus rheology to "solidify" human mucus at the nanoscale
    Samuel K Lai
    Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, Maryland, USA
    PLoS ONE 4:e4294. 2009
    ..These findings provide important insight into the nanoscale structural and barrier properties of mucus, and how the penetration of foreign particles across mucus might be inhibited...
  36. ncbi Endothelium oriented differentiation of bone marrow mesenchymal stem cells under chemical and mechanical stimulations
    Ke Bai
    School of Biological Science and Medical Engineering, Beijing University of Aeronautics and Astronautics, No 37 Xueyuan Road, Beijing 100191, China
    J Biomech 43:1176-81. 2010
    ..e. at 48 hr, of shear stimulation. Our study demonstrates that chemical and mechanical stimulations work together in determining MSC differentiation dynamics...
  37. ncbi Dynamic recording of irrigating fluid distribution in root canals using thermal image analysis
    Y D Hsieh
    School of Dentistry, National Defense Medical Centre, Taipei, Taiwan
    Int Endod J 40:11-7. 2007
    ..To investigate the influence of the size and the depth of insertion of irrigating needles, and the diameter of the master apical file on flow distribution during fluid irrigation in root canals...
  38. pmc Mechanics of single cells: rheology, time dependence, and fluctuations
    Gladys Massiera
    Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biophys J 93:3703-13. 2007
    ..This approach is well suited for accurately determining the rheology of single cells, the study of temporal and cell-to-cell variations in the MTC signal amplitude, and assessing the ..
  39. ncbi Q10-loaded NLC versus nanoemulsions: stability, rheology and in vitro skin permeation
    Varaporn B Junyaprasert
    Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Thailand
    Int J Pharm 377:207-14. 2009
    ..From in vitro permeation studies, it could be stated that the amount of Q(10) released and occlusiveness were major keys to promote the deep penetration of Q(10) into the skin...
  40. pmc Micro-PTV measurement of the fluid shear stress acting on adherent leukocytes in vivo
    John E Pickard
    Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA
    Biophys J 96:4249-59. 2009
    ..The flow field around adherent leukocytes in vivo allows more accurate estimates of bond forces in rolling and adherent leukocytes and improved modeling studies...
  41. pmc Biomechanics: cell research and applications for the next decade
    Dennis Discher
    University of Pennsylvania, Philadelphia, PA, USA
    Ann Biomed Eng 37:847-59. 2009
    ..Such insights will no doubt inform basic biology and rational engineering of effective new approaches to clinical therapy...
  42. ncbi Direct measurements of the kinematics and dynamics of bat flight
    Xiaodong Tian
    Brown University, Providence, RI 02912, USA
    Bioinspir Biomim 1:S10-8. 2006
    ..Data synthesis of several discrete realizations suggests a 'cartoon' of the wake structure during the entire wing beat cycle. Considerable work remains to be done to confirm and amplify these results...
  43. pmc Differences in the microrheology of human embryonic stem cells and human induced pluripotent stem cells
    Brian R Daniels
    Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, Maryland, USA
    Biophys J 99:3563-70. 2010
    ....
  44. ncbi Modeling cell rheology with the Subcellular Element Model
    Sebastian A Sandersius
    Department of Physics, Arizona State University, Tempe, AZ 85287, USA
    Phys Biol 5:015002. 2008
    ..Employing virtual methods of bulk rheology and microrheology we find that the SEM successfully captures many cellular rheological properties at intermediate ..
  45. ncbi Enhanced viscoelasticity of human cystic fibrotic sputum correlates with increasing microheterogeneity in particle transport
    Michelle Dawson
    Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Biol Chem 278:50393-401. 2003
    ....
  46. ncbi The mechanical environment of bone marrow: a review
    Umut Atakan Gurkan
    Weldon School of Biomedical Engineering, Purdue University, 206 S Martin Jischke Drive, West Lafayette, IN 47907 2032, USA
    Ann Biomed Eng 36:1978-91. 2008
    ..The aim of this review is to highlight the marrow tissue within the context of its mechanical environment during normal physiology and underline perturbations during disease...
  47. ncbi Nano-microscale models of periosteocytic flow show differences in stresses imparted to cell body and processes
    Eric J Anderson
    Department of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, OH, USA
    Ann Biomed Eng 33:52-62. 2005
    ..Hence, this model simulates subcellular effects of fluid flow and suggests, for the first time to our knowledge, major differences in modes of loading between the domain of the cell body and that of the cell process...
  48. ncbi Influence of chondroitin sulfate on collagen gel structure and mechanical properties at physiologically relevant levels
    Kate Stuart
    Purdue University, Biomedical Engineering, 206 Martin Jischke Drive, West Lafayette, Indiana 47907, USA
    Biopolymers 89:841-51. 2008
    ..The results of this study demonstrate that collagen organization can be modified by the addition of GAG, leading to altered matrix mechanical properties...
  49. ncbi Fluid shear stress activation of focal adhesion kinase. Linking to mitogen-activated protein kinases
    S Li
    Department of Bioengineering and Institute for Biomedical Engineering, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 272:30455-62. 1997
    ..These results demonstrate that FAK signaling is critical in the shear stress-induced dual activation of ERK and JNK...
  50. ncbi Removal of the MDCK cell primary cilium abolishes flow sensing
    H A Praetorius
    Water and Salt Research Center, IEKF, University of Aarhus, Brendstrupgaardsvej, DK8200 Aarhus N, Denmark
    J Membr Biol 191:69-76. 2003
    ..We conclude that the primary cilium is the only sensor for the flow-induced Ca2+ response in MDCK cells and estimate that a single mechanically sensitive channel in the cilium could provide the requisite Ca2+ influx...
  51. ncbi Pore size variable type I collagen gels and their interaction with glioma cells
    Ya li Yang
    Department of Chemistry, Columbia University, New York, NY 10027, USA
    Biomaterials 31:5678-88. 2010
    ..Proof of principle studies of glioma invasion in these gels suggested pore size is a key determinant of glioma invasive speed in collagen gels...
  52. ncbi Advantages in using multi-frequency driving ultrasound for optimizing echo particle image velocimetry techniques
    Hairong Zheng
    Department of Mechanical Engineering, University of Colorado, Boulder, CO 80309 0427, USA
    Biomed Sci Instrum 40:371-6. 2004
    ....
  53. ncbi Two-compartment modelling of respiratory system mechanics at low frequencies: gas redistribution or tissue rheology?
    T Similowski
    Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    Eur Respir J 4:353-8. 1991
    ..Additional experimental data are required in order to identify such a model, and to quantify these two phenomena...
  54. ncbi Microvascular rheology of Definity microbubbles after intra-arterial and intravenous administration
    Jonathan R Lindner
    Cardiac Imaging Center, The Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, USA
    J Am Soc Echocardiogr 15:396-403. 2002
    The microvascular rheology and extent of pulmonary retention of second-generation microbubble ultrasound contrast agents has not previously been well characterized...
  55. ncbi Effect of hydroxyapatite morphology/surface area on the rheology and processability of hydroxyapatite filled polyethylene composites
    R Joseph
    IRC in Biomedical Materials, Queen Mary University of London, Mile End Road, London, E1 4NS, UK
    Biomaterials 23:4295-302. 2002
    ..This paper addresses the effect of morphological features of HA on the rheology and processability of an injection-moulding grade HA-HDPE composite...
  56. ncbi Scaling the microrheology of living cells
    B Fabry
    Physiology Program, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
    Phys Rev Lett 87:148102. 2001
    ..The practical implications are that the effective noise temperature is an easily quantified measure of the ability of the cytoskeleton to deform, flow, and reorganize...
  57. ncbi Rheological properties of contraceptive gels
    D H Owen
    Department of Biomedical Engineering, Duke University, Durham, NC, USA
    Contraception 62:321-6. 2000
    ..Conceptrol and Gynol II had no residual stress, while both KY Plus and Advantage-S did. The gels differed in their response to dilution with vaginal fluid simulant...
  58. pmc Time-resolved vortex wake of a common swift flying over a range of flight speeds
    P Henningsson
    Department of Theoretical Ecology, Lund University, 223 62 Lund, Sweden
    J R Soc Interface 8:807-16. 2011
    ..It is proposed that this is due to the body disrupting the lift distribution over the wing by generating less lift than the wings...
  59. ncbi The vortex wake of blackcaps (Sylvia atricapilla L.) measured using high-speed digital particle image velocimetry (DPIV)
    L C Johansson
    Department of Theoretical Ecology, Lund University, Ecology Building, SE 223 62 Lund, Sweden
    J Exp Biol 212:3365-76. 2009
    ..Neither did we find support for the hypothesis that the tail should reduce the drag of the bird. The function of the tail during steady flight thus remains unclear and calls for further investigation in future studies...
  60. pmc Characterization of the rheological, mucoadhesive, and drug release properties of highly structured gel platforms for intravaginal drug delivery
    Gavin P Andrews
    Drug Delivery and Biomaterials Group, The School of Pharmacy, The Queen s University of Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast, BT9 7BL, Northern Ireland, United Kingdom
    Biomacromolecules 10:2427-35. 2009
    ..It is considered that these semisolid drug delivery systems may be useful as site-retentive platforms for the sustained delivery of therapeutic agents to the vagina...
  61. pmc Measurements of the wall shear stress distribution in the outflow tract of an embryonic chicken heart
    C Poelma
    Laboratory for Aero and Hydrodynamics, Delft University of Technology, Leeghwaterstraat 21, 2628 CA Delft, The Netherlands
    J R Soc Interface 7:91-103. 2010
    ..The most significant error is the location of the wall, which results in an estimate of the uncertainty in the WSS values of 20 per cent...
  62. ncbi A model for strain amplification in the actin cytoskeleton of osteocytes due to fluid drag on pericellular matrix
    L You
    Department of Mechanical Engineering, The Center for Biomedical Engineering, City College of New York, The City University of New York, Convent Avenue at 140th Street, New York, NY 10031, USA
    J Biomech 34:1375-86. 2001
    ....
  63. pmc A multiscale red blood cell model with accurate mechanics, rheology, and dynamics
    Dmitry A Fedosov
    Division of Applied Mathematics, Brown University, Providence, Rhode Island, USA
    Biophys J 98:2215-25. 2010
    ..We present a multiscale RBC model that is able to predict RBC mechanics, rheology, and dynamics in agreement with experiments...
  64. ncbi Mechanical stress induces Interleukin-11 expression to stimulate osteoblast differentiation
    Shinsuke Kido
    Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Medical Sciences, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Bone 45:1125-32. 2009
    ....
  65. ncbi The genetic control of milling yield, dough rheology and baking quality of wheat
    H Kuchel
    Australian Grain Technologies Pty Ltd, University of Adelaide, Roseworthy Campus, 5371, Roseworthy, SA, Australia
    Theor Appl Genet 112:1487-95. 2006
    ..Molineux' is superior to 'Trident' for a number of milling, dough rheology and baking quality characteristics, although by international standards 'Trident' would still be regarded as ..
  66. pmc Structural hierarchy governs fibrin gel mechanics
    Izabela K Piechocka
    Biological Soft Matter Group, Foundation for Fundamental Research on Matter, Institute for Atomic and Molecular Physics, Amsterdam, The Netherlands
    Biophys J 98:2281-9. 2010
    ..Here we investigate the physical origin of this mechanical behavior by performing rheology measurements on reconstituted fibrin gels...
  67. pmc Rheological characterization of the bundling transition in F-actin solutions induced by methylcellulose
    Simone Köhler
    Lehrstuhl für Biophysik E27, Technische Universitat Munchen, Garching, Germany
    PLoS ONE 3:e2736. 2008
    ..As a consequence, the effect of methylcellulose on actin solutions has to be considered very carefully when MC is used in biochemical experiments...
  68. ncbi Dilution of microbicide gels with vaginal fluid and semen simulants: effect on rheological properties and coating flow
    Bonnie E Lai
    Department of Biomedical Engineering, Duke University, Box 90281 Durham, North Carolina 27708, USA
    J Pharm Sci 97:1030-8. 2008
    ..There were differences in the responses of the three materials to dilution. Even small dilutions altered the rank order of vaginal coating rates compared to the undiluted formulations...
  69. pmc Interstitial flow promotes vascular fibroblast, myofibroblast, and smooth muscle cell motility in 3-D collagen I via upregulation of MMP-1
    Zhong Dong Shi
    Department of Biomedical Engineering, City College of New York, City University of New York, New York 10031, USA
    Am J Physiol Heart Circ Physiol 297:H1225-34. 2009
    ..Our findings shed light on the mechanism by which vascular SMCs and FBs/MFBs contribute to intimal thickening in regions of vascular injury where interstitial flow is elevated...
  70. pmc Fluid shear stress promotes an endothelial-like phenotype during the early differentiation of embryonic stem cells
    TABASSUM AHSAN
    Department of Biomedical Engineering, Tulane University, New Orleans, Louisiana 70118, USA
    Tissue Eng Part A 16:3547-53. 2010
    ..Thus, shear stress may be used to direct differentiation of embryonic stem cells toward an endothelial-like phenotype, helping to address the cell sourcing issue in cardiovascular regenerative medicine and tissue engineering...
  71. ncbi Ultrasonic rheology of a monoclonal antibody (IgG2) solution: implications for physical stability of proteins in high concentration formulations
    Atul Saluja
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, CT 06269, USA
    J Pharm Sci 96:3181-95. 2007
    ..stability of a model monoclonal antibody (IgG(2)), as determined by extent of aggregation, was related to rheology of its solutions...
  72. pmc Local rheology of human neutrophils investigated using atomic force microscopy
    Yong J Lee
    School of Mechanical Engineering, Kyungpook National University, Daegu, South Korea
    Int J Biol Sci 7:102-11. 2011
    ..Using the Atomic Force Microscopy (AFM)-based micro-rheology, we have investigated rheological properties of the adherent human neutrophils on local nano-domains...
  73. ncbi Effects of oxidized fibrinogen on the functions of blood cells, blood clotting, and rheology
    O A Azizova
    Laboratory of Biophysical Bases of Pathology, Institute of Physicochemical Medicine, Federal Agency for Health Care and Social Development, Moscow
    Bull Exp Biol Med 144:397-407. 2007
    ..Hence, oxidized fibrinogen plays an important role in the development of atherosclerosis and its complications (thromboses)...
  74. ncbi Ex vivo rheology of spider silk
    N Kojic
    Hatsopoulos Microfluids Laboratory, Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Exp Biol 209:4355-62. 2006
    ..Quantifying the properties of native spinning solutions provides new guidance for adjusting the spinning processes of synthetic or genetically engineered silks to match those of the spider...
  75. ncbi Dealing with mechanics: mechanisms of force transduction in cells
    Paul A Janmey
    Departments of Physiology and Physics, University of Pennsylvania, Institute for Medicine and Engineering, 3340 Smith Walk, Philadelphia, PA 19104, USA
    Trends Biochem Sci 29:364-70. 2004
  76. pmc Focal adhesion kinase is important for fluid shear stress-induced mechanotransduction in osteoblasts
    Suzanne R L Young
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Bone Miner Res 24:411-24. 2009
    ..These data indicate the importance of FAK for both short and long periods of FSS-induced mechanotransduction in osteoblasts...
  77. ncbi Effect of barium sulfate contrast medium on rheology and sensory texture attributes in a model food
    O Ekberg
    Diagnostic Centre of Imaging and Functional Medicine, Department of Clinical Sciences Medical Radiology, Malmo University Hospital, Malmo, Sweden
    Acta Radiol 50:131-8. 2009
    ..The swallowing process can be visualized using videoradiography, by mixing food with contrast medium, e.g., barium sulfate (BaSO(4)), making it radiopaque. The sensory properties of foods may be affected by adding this medium...
  78. ncbi 3D computational modeling and simulation of leukocyte rolling adhesion and deformation
    Vijay Pappu
    Department of Mechanical and Aerospace Engineering, Rutgers University, The State University of New Jersey, 98 Brett Road, Piscataway, NJ 08854, USA
    Comput Biol Med 38:738-53. 2008
    ..The force loading on individual microvillus and selectin bond is not continuous, rather occurs in steps. Further, we find that the peak force on a tethered microvillus is much higher than that measured to cause tether extrusion...
  79. ncbi Long- and short-range electrostatic interactions affect the rheology of highly concentrated antibody solutions
    Ravi Chari
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, 69 North Eagleville Rd, U 3092, Storrs, Connecticut 06269, USA
    Pharm Res 26:2607-18. 2009
    ..To explain the differences in protein-protein interactions (PPI) of concentrated versus dilute formulations of a model antibody...
  80. ncbi Is red blood cell rheology preserved during routine blood bank storage?
    Sandra Henkelman
    Department of Biomedical Engineering, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Transfusion 50:941-8. 2010
    ..In this study, the rheologic properties and cell variables of leukoreduced RBC units, during routine blood bank storage in saline-adenine-glucose-mannitol, were investigated...
  81. pmc High-resolution fluid-structure interaction simulations of flow through a bi-leaflet mechanical heart valve in an anatomic aorta
    Iman Borazjani
    St Anthony Falls Laboratory, Department of Civil Engineering, University of Minnesota, Minneapolis, MN, USA
    Ann Biomed Eng 38:326-44. 2010
    ....
  82. ncbi Vector tomographic X-ray phase contrast velocimetry utilizing dynamic blood speckle
    Sarah C Irvine
    School of Physics, Monash University, Victoria 3800, Australia
    Opt Express 18:2368-79. 2010
    ..This vector tomographic phase-retrieval velocimetry was performed over the full pumping cycle, to completely characterize the velocity field of the pulsatile blood flow in both space and time...
  83. ncbi Analysis of early embryonic great-vessel microcirculation in zebrafish using high-speed confocal μPIV
    Chia Yuan Chen
    Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15219, USA
    Biorheology 48:305-21. 2011
    ....
  84. ncbi Development and in-vivo characterization of supramolecular hydrogels for intrarenal drug delivery
    Patricia Y W Dankers
    Department of Pathology and Medical Biology, Stem Cells and Tissue Engineering Group, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Biomaterials 33:5144-55. 2012
    ..The favourable biological behaviour of the supramolecular hydrogels makes them exquisite candidates for subcapsular drug delivery, and paves the way to various opportunities for intrarenal therapy...
  85. ncbi Simultaneous control of pH and ionic strength during interfacial rheology of β-lactoglobulin fibrils adsorbed at liquid/liquid Interfaces
    Patrick A Rühs
    Institute of Food, Nutrition and Health, ETH Zurich, Zurich, Switzerland
    Langmuir 28:12536-43. 2012
    ..The method developed in this study allows in situ subphase exchange during interfacial rheological measurements and the investigation of interfacial ordering...
  86. pmc Slip-flow and heat transfer of a non-newtonian nanofluid in a microtube
    Jun Niu
    State Key Laboratory for Turbulence and Complex Systems, College of Engineering, Peking University, Beijing, China
    PLoS ONE 7:e37274. 2012
    ..The slip-flow and heat transfer of a non-Newtonian nanofluid in a microtube is theoretically studied. The power-law rheology is adopted to describe the non-Newtonian characteristics of the flow, in which the fluid consistency coefficient ..
  87. ncbi Bat flight generates complex aerodynamic tracks
    A Hedenstrom
    Department of Theoretical Ecology, Lund University, SE 223 62 Lund, Sweden
    Science 316:894-7. 2007
    ..Our interpretations of the unsteady aerodynamic performance and function of membranous-winged, flapping flight should change modeling strategies for the study of equivalent natural and engineered flying devices...
  88. ncbi Dysphagia dietary guidelines and the rheology of nutritional feeds and barium test feeds
    Lindsay Strowd
    Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, NC 27157 1081, USA
    Chest 133:1397-401. 2008
    ..Dysphagia diet foods (DDF) are thickened as recommended by the National Dysphagia Diet (NDD) guidelines. To our knowledge, there are no published data evaluating if the viscosity of BTF or commercial DDF meet NDD guidelines...
  89. ncbi Colloidal interaction in ionic liquids: effects of ionic structures and surface chemistry on rheology of silica colloidal dispersions
    Kazuhide Ueno
    Department of Chemistry and Biotechnology, Yokohama National University 79 5 Tokiwadai, Hodogaya ku, Yokohama 240 8501, Japan
    Langmuir 25:825-31. 2009
    To understand the important factors that dominate colloidal stability in ionic liquids (ILs), rheology of the dispersions of hydrophilic and hydrophobic silica nanoparticles were investigated in ILs with different ionic structures...
  90. ncbi Interfacial rheology of surface-active biopolymers: Acacia senegal gum versus hydrophobically modified starch
    Philipp Erni
    Institute of Food Science and Nutrition and Materials Research Center, ETH Zurich, 7 Rue de la Bergère, Zurich, Switzerland
    Biomacromolecules 8:3458-66. 2007
    ..We study the interfacial rheology of its adsorption layers at the oil/water interface and compare it with adsorbed layers of hydrophobically ..
  91. pmc Fluid shear stress alters the hemostatic properties of endothelial outgrowth cells
    Ann E Ensley
    Parker H Petit Institute for Bioengineering and Bioscience and Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA
    Tissue Eng Part A 18:127-36. 2012
    ..Accordingly, manipulation of EOC phenotype by mechanical forces may be important for the development of thrombo-resistant surfaces on engineered vascular implants...
  92. ncbi Using in situ rheology to characterize the microstructure in photopolymerized polyacrylamide gels for DNA electrophoresis
    Jian Wang
    Artie McFerrin Department of Chemical Engineering, Texas A and M University, College Station, 77843 3122, USA
    Electrophoresis 27:3349-58. 2006
    ..photopolymerization of cross-linked polyacrylamide electrophoresis gels to investigate the relationship between rheology and parameters associated with the gelation environment including UV intensity, monomer and cross-linker ..
  93. ncbi Rheology and UV-protecting properties of complex suspensions of titanium dioxides and zinc oxides
    Akio Nasu
    Material Science Research Center, Shiseido Co, Ltd 2 2 1, Hayabuchi, Tsuzuki ku, Yokohama shi 224 8558, Japan
    J Colloid Interface Sci 310:617-23. 2007
    ....
  94. ncbi A power-law rheology-based finite element model for single cell deformation
    E H Zhou
    Program in Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Biomech Model Mechanobiol 11:1075-84. 2012
    ..as spring-dashpot viscoelastic materials, while broad experimental data are now lending support to the power-law rheology (PLR) model...
  95. ncbi Three-dimensional numeric simulation of root canal irrigant flow with different irrigation needles
    Ya Shen
    Division of Endodontics, Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, British Columbia, Canada
    J Endod 36:884-9. 2010
    ..The purpose of this study was to investigate, by using computational fluid dynamics (CFD), the effect of needle tip design on irrigant flow pattern...
  96. ncbi The rheology of colloidal and noncolloidal food dispersions
    D B Genovese
    PLAPIQUI UNS CONICET, Camino La Carrindanga Km 7, 8000 Bahia Blanca, Argentina
    J Food Sci 72:R11-20. 2007
    ..In this review, recent studies on colloidal and noncolloidal food dispersions in which theoretical models as well as structural analysis were employed are discussed...
  97. ncbi Rheology of the vitreous gel: effects of macromolecule organization on the viscoelastic properties
    Pooria Sharif-Kashani
    Department of Mechanical and Aerospace Engineering, University of California, Los Angeles, 420 Westwood Plaza, Los Angeles, CA 90095, USA
    J Biomech 44:419-23. 2011
    ..Consequently, we were able to differentiate the role of each main component from the overall viscoelastic properties...
  98. ncbi Development and validation of a three-dimensional computational fluid dynamics model of root canal irrigation
    Yuan Gao
    State Key Laboratory of Oral Diseases, West China College and Hospital of Stomatology, Sichuan University, Chengdu, China
    J Endod 35:1282-7. 2009
    ..The aim was to construct a three-dimensional computational fluid dynamics (CFD) model of root canal irrigation, with a suitable turbulence model, and validate it to provide a novel method for studying the root canal irrigation...
  99. ncbi Development of a custom-designed echo particle image velocimetry system for multi-component hemodynamic measurements: system characterization and initial experimental results
    Lingli Liu
    Department of Mechanical Engineering, University of Colorado, Boulder, CO 80309 0427, USA
    Phys Med Biol 53:1397-412. 2008
    ..The experimental results verified the accuracy of this technique and indicated the promise of the custom Echo PIV system in capturing complex flow fields non-invasively...
  100. pmc Dynamic role of cross-linking proteins in actin rheology
    Taeyoon Kim
    Institute for Biophysical Dynamics, University of Chicago, Chicago, Illinois, USA
    Biophys J 101:1597-603. 2011
    ..These results suggest that despite the possibility of unfolding, unbinding of ACPs is the major determinant for the rheology of the actin network.
  101. ncbi Thermosetting gels with modulated gelation temperature for ophthalmic use: the rheological and gamma scintigraphic studies
    Gang Wei
    School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
    J Control Release 83:65-74. 2002
    ..However, no further improvement in the ocular retention was observed when adding HA-Na into the thermosetting gel due to the substantially decreased gel strength...

Research Grants63

  1. Rheologic and Vascular Modulators in Sickle Vaso-occlusion
    Dhananjay K Kaul; Fiscal Year: 2012
    ..Chronic hypoxia is a predictable consequence of abnormal red cell rheology, sickling, hemolytic anemia and recurring vaso-occlusive episodes...
  2. 3D Differentiation of Mesenchymal Stem Cells in Peptide Amphiphile Matrices
    John B Matson; Fiscal Year: 2011
    ..Characterization of the gel will be accomplished using electron microscopy, small-angle X-ray scattering, rheology, and circular dichroism...
  3. Computational and Cell Culture Models for Mucus Clearance
    Richard Superfine; Fiscal Year: 2010
    ..to act as a sensitive as- say for environmental effectors that compromise mucus height regulation, mucus rheology, cilia density and co- ordination...
  4. Biomechanics of Blood Stream Infections
    John G Younger; Fiscal Year: 2012
    ..therapeutically? The clinical impact of this work will be to open new therapeutic avenues that address the rheology and mechanics of intravascular infection...
  5. Role of Surface Roughness in Regulating Tumor Cell Behavior
    Sarah C Glover; Fiscal Year: 2012
    ..colonic epithelial cell lines on ECMs of defined microtopography using standard molecular techniques, cell rheology, and advanced imaging...
  6. Inhaled aerosols for prevention and treatment of respiratory infections
    Robert W Clarke; Fiscal Year: 2013
    ..Specific Aims 1. Define the effect of salt aerosols on rheology and the formation of bioaerosols from airway lining fluid using an in vitro simulated cough system and ..
  7. Preventing fucose-dependent binding of aspergillus and pseudomonas to lung mucin
    John V Fahy; Fiscal Year: 2012
    ..b>Rheology will provide a measure of mucin cross-linking in the mucus samples so that we can determine the mucolytic effects ..
  8. LIPID AND PROTEIN EFFECTS ON MONOLAYER STABILITY
    JOSEPH ANTHONY ZASADZINSKI; Fiscal Year: 2013
    ..of clinical and model lung surfactants as a function of cholesterol composition using macro- and micro- rheology instruments unique to our laboratory...
  9. Development of a Biomimetic Vitreous Substitute
    Nathan Ravi; Fiscal Year: 2013
    ..resonance, Fourier transform infrared, raman, circular dichroism, and light- scattering spectroscopies, and rheology. Computational and macromolecular modeling techniques will be employed to study the relationship between the ..
  10. Multimodal biophysical markers of vascular disease in hemoglobinopathies
    Lonnie K Zeltzer; Fiscal Year: 2013
    ..will be made in human subjects with selected hematological disorders that differ in degree of anemia or blood rheology. We will also study SCD patients on chronic transfusion with varying percent hemoglobin S in order to separate ..
  11. Computer Integrated Systems for Microscopy and Manipulation
    Richard Superfine; Fiscal Year: 2013
    ..mucin, myosin, MutS) to macromolecular complexes (fibrin fibers, viruses), cells (Plexin, cell motility, cell division), tissue cultures (human lung cell cultures) and macroscopic biomaterial properties (mucus rheology).
  12. Airway mucus/mucin composition and proteome in COPD: A SPIROMICS ancillary study
    Mehmet Kesimer; Fiscal Year: 2013
    ..These alterations produce a mucus that has an aberrant rheology, that is poorly transportable by normal ciliary and cough clearance mechanisms...
  13. Mechanically Stable Blood Substitutes
    Andre Francis Palmer; Fiscal Year: 2010
    ..Determine the structure and mechanics of individual actin-hemoglobin containing liposomes, and relate this to the rheology and average bending elasticity of actin-hemoglobin containing liposome dispersions...
  14. Multiscale Modeling of Sickle Cell Anemia: Methods and Validation
    Peter G Vekilov; Fiscal Year: 2013
    ..and validated from comprehensive single-cell measurements, will be used to predict the collective dynamics and rheology of SCD blood flow...
  15. Disease States of Red Blood Cells in Vascular Microvessels
    PANAGIOTIS DIMITRAKOPOULOS; Fiscal Year: 2010
    ..situation in which a physiological deviation from homeostasis, such as a disease state, involves a change in the rheology of the microcirculation...
  16. Development of a method for in situ nanorheology of human airway mucus
    Amy L Oldenburg; Fiscal Year: 2013
    ..the DLS-OCT nanorheology technique in controlled complex fluids against standard bead microrheology and bulk rheology. Subsequently, we will validate this technique using non- muco-adherent GNRs in mucus harvested from human ..
  17. Clinical and Molecular Phenotypes of Severe Asthma
    John V Fahy; Fiscal Year: 2013
    ..Aim 2 will explore mechanisms of pathologic mucus in severe asthma in two sub-aims that will both use rheology to quantify the viscoelastic properties of induced sputum from patients with chronic severe asthma...
  18. Molecular Pathogenesis and Phenotype of Acquired CFTR Dysfunction in COPD
    STEVEN MARK ROWE; Fiscal Year: 2013
    ..effects of tobacco exposure and CFTR modulation on airway surface liquid regulation, mucus transport, and mucus rheology using novel methods we have developed to characterize basic properties of pulmonary epithelia...
  19. NORTHERN CALIFORNIA COMPREHENSIVE SICKLE CELL CENTERS
    ELLIOTT P VICHINKSY; Fiscal Year: 2010
    ..with the four sickle haplotypes: Benin, CAR, Senegal and Saudi Arabia, and to study their pathophysiology and rheology. E) Our network project's aim is to test hypothesis that a non-myeloablative conditioning regimen in young ..
  20. Tumor microenvironment, tissue liquidity, and cell interaction in prostate cancer
    Ramsey A Foty; Fiscal Year: 2012
    ..The information generated will establish a connection between tumor rheology and its molecular underpinnings...
  21. The Virtual Lung Project: Integrated Modeling of Epithelial Fluid Flows
    Richard Superfine; Fiscal Year: 2010
    ..and simulation have begun to tackle issues such as the basis for force production in biological molecules, the rheology of biological fluids and hydrodynamics of viscous, complex flows...
  22. Mucus Adhesion to Epithelial Cells and its Mobilization in COPD and CF
    Michael Rubinstein; Fiscal Year: 2012
    ..In Sp. Aim 1, we will develop experiments, such as peel tests and cavitation rheology technique (CRT) in cultured cell preparations, which would allow us for the first time to measure the adhesion ..
  23. Integrative colloidal gels for cranial defect repair
    Cory Berkland; Fiscal Year: 2013
    ..gels from the two major classes of scaffolding biomaterials (hydrogels and solid scaffolds) is their paste-like rheology, which in turn is attributed to electrostatic interaction of the nanoparticle constituents...
  24. Highly resilient, hydrophilic bioelastomers for engineering vocal fold tissue
    Kristi L Kiick; Fiscal Year: 2013
    ..stem cells (hMSCs) in these matrices under both static and dynamic conditions, and employ a suite of oscillatory rheology, tensile testing, and high-frequency torsional-wave methods to characterize the mechanical properties of cell-..
  25. Designing Optimal Microbicide Delivery Integrating Rheology and Acceptability
    GREGORY RAY ZIEGLER; Fiscal Year: 2012
    ....
  26. Biotechnology Research Partnerships Renewal: Aggregation of Therapeutic Proteins
    Theodore W Randolph; Fiscal Year: 2013
    ..energy transfer, small angle neutron scattering, small angle x-ray scattering micro-flow imaging, surface micro-rheology, chromatography, circular dichroism spectroscopy and infrared spectroscopy...
  27. Designing Optimal Microbicide Delivery Integrating Rheology and Acceptability
    JOHN EDWARD HAYES; Fiscal Year: 2013
    ..Critically, our product type is flexible - allowing for multiple textures, sizes, shapes and antiviral strategies - to accommodate a range of user preferences. ..
  28. Mechanism-based therapies for pancreatic cancer informed by stromal microrheology
    Jonathan P Celli; Fiscal Year: 2012
    ..3D model system informed by studies on ex vivo tumors from orthotopic PanCa mice, to assess the impact of matrix rheology (measured by FLTM and traditional bulk rheology) on growth and development of 3D in vitro tumors...
  29. Blood rheology: analytical approaches to sickle cell disease
    Lance Munn; Fiscal Year: 2009
    ..Unfortunately, many mechanisms contribute to the abnormal rheology of blood in sickle cell disease (SCD), and it is not clear which are the most promising targets for therapy...
  30. ECHOCARDIOGRAPHIC ASSESSMENT OF MYOCARDIAL PERFUSION
    Sanjiv Kaul; Fiscal Year: 2004
    ..Because microbubbles have an intravascular rheology similar to that of red blood cells, contrast-enhanced ultrasound can be used to measure microbubble (or red blood ..
  31. ECHOCARDIOGRAPHIC ASSESSMENT OF MYOCARDIAL PERFUSION
    Sanjiv Kaul; Fiscal Year: 2002
    ..Because microbubbles have an intravascular rheology similar to that of red blood cells, contrast-enhanced ultrasound can be used to measure microbubble (or red blood ..
  32. Injectable microgel for soft tissue repair
    Joseph C Salamone; Fiscal Year: 2013
    ..b>Rheology will be used to determine their viscoelastic properties to quantify solution properties, gel- like behavior, and ..
  33. IMMUNOPROBES FOR LUBRICIN FROM HUMAN SYNOVIAL FLUID
    Gregory Jay; Fiscal Year: 2003
    ..Most reports actually deal with the rheology of synovial fluid and may incorrectly assume that its viscosity is the basis for joint lubrication (5-10)...
  34. Food Rheology and Exercise in Aging Humans
    WAYNE CAMPBELL; Fiscal Year: 2009
    ..abstract_text> ..
  35. HEMORHEOLOGY IN SICKLE CELL ANEMIA AND RELATED DISORDERS
    HERBERT MEISELMAN; Fiscal Year: 1993
    This program is designed to provide a multifaceted approach to the study of in vitro blood and cell rheology in sickle cell disease; the long range goal of the program is a better comprehension of the physiological significance of ..
  36. Blood rheology, cell adhesion and endothelial activation
    Lance Munn; Fiscal Year: 2007
    ..A combination of in vivo experiments and mathematical modeling will be used to assess the combination of fluid forces and vessel geometries that lead to atherosclerotic lesions. ..
  37. ROLE OF ACTIN IN PURULENT SPUTUM MECHANICS
    THOMAS STOSSEL; Fiscal Year: 1999
    ..viscosity and therefore work synergistically with each other and with other candidate mucolytic agents to alter rheology of purulent sputum. 2...
  38. MICROVASCULAR ENDOTHELIAL FUNCTION WITH MICROBUBBLES
    Jonathan Lindner; Fiscal Year: 2002
    ..Microbubbles used to produce opacification during CEU are ideal flow tracers since they have a similar rheology as red blood cells and do not alter hemodynamics...
  39. H AND HC03 TRANSPORT BY AIRWAY EPITHELIA IN CF
    Terry Machen; Fiscal Year: 2004
    ..by airway epithelial cells likely play key roles in cystic fibrosis (CF) due to effects on mucus hydration and rheology, ciliary transport, bacterial binding and anti-microbial factors...
  40. MICRORHEOLOGIC MECHANISMS IN VASCULAR PATHOPHYSIOLOGY
    SALVATORE SUTERA; Fiscal Year: 1992
    ..In the longer term the applicability of the rheoscope to the study of white cell rheology will be tested...
  41. STRUCTURE INTERACTION AND MECHANISM IN SICKLE HEMOGLOBIN
    ROBIN BRIEHL; Fiscal Year: 2006
    ..4) The red cell. The deleterious effects of solid-like rheology and rapid kinetics operate through effects on the red cell...
  42. MUC19, a novel gel-forming mucin in salivary glands
    Yin Chen; Fiscal Year: 2005
    ..Changes in salivary mucus rheology may affect the phyological properties of saliva that is associated with various diseases...
  43. Ultra High-Speed Imaging System
    Pei Zhong; Fiscal Year: 2003
    ..and activation, DNA transport across the plasma and nuclei membranes of the cells during electroporation, and rheology of red blood cells in tumor microcirculation...
  44. IN VIVO MEASUREMENT OF WALL SHEAR STRESS IN THE AORTA
    Gerald Miller; Fiscal Year: 1980
    ..stress can then be computed from wall shear rate and viscosity data utilizing a constitutive model for blood rheology. Both peak and mean wall shear stress levels are to be determined for twenty dogs in order to correlate in vivo ..
  45. PROMOTION OF WOUND VASCULARIZATION AND CLOSURE
    Ronald Hill; Fiscal Year: 2005
    ..analysis will use FTIR and SEC-MALLS to determine the extent and nature of interactions within the co-polymer and rheology to examine the physical properties of E-Matrix (TM) ...
  46. SICKLE HEMOGLOBIN: PHYSICAL CHEMISTRY AND PATHOGENESIS
    ROBIN BRIEHL; Fiscal Year: 1992
    ..S gels, (c) the effects of shear, which can occur within red cells, in accelerating kinetics greatly and on rheology, and (d) the structural bases of each of these phenomena...
  47. 3D Force Microscopy for Microheology & Active Transport
    Richard Superfine; Fiscal Year: 2006
    ..We propose to develop magnetic bead manipulation into a new microscopic technology for studying forces and rheology in biological systems. There are three trends that make now the opportune time to make rapid progress...
  48. MBRS SCORE Program at Alabama A&M University
    PURUSHOTTAM KALE; Fiscal Year: 2006
    ..The subprojects are 1) Nonlinear optical study of blood rheology (Dr. Curley); 2) Optimization of the production of a fertile hypoallergenic peanut plant using A. tumefaciens (Dr...
  49. Hearing in Noise with Improved Noise Reduction Foam
    VASANT KOLPE; Fiscal Year: 2006
    ..Phase II will consist of defining the basic science, i.e., rheology of the enhanced viscoelastic foam material, to lay a foundation for the development of manufacturing processes ..
  50. Polymer nanoparticles that cross mucus
    Justin Hanes; Fiscal Year: 2009
    ..We will quantify the effects of these reagents on mucus rheology (e.g...
  51. Stereoselective Polymerization of Vinylethers
    ADRIEN LAVOIE; Fiscal Year: 2002
    A polymer's stereoregularity influences its rheology and thus, its potential as a useful material. As such, the next generation of biocompatible polymers is dependent upon the ability to precisely control stereoregularity...
  52. RESEARCH TRAINING IN DENTAL MATERIALS SCIENCE
    PHILLIP MESSERSMITH; Fiscal Year: 2001
    ..modern state of the art equipment for ultrastructure, corrosion, mechanical properties, cell culturing, rheology, spectral analysis, and specimen fabrication...
  53. Blood Rheology and Leukocyte Mechanics
    Lance Munn; Fiscal Year: 2005
    ..role in leukocyte-endothelial (L-E) interactions, both in vitro and in vivo through the unique suspension rheology characteristics that they impart to blood...
  54. MATHEMATICAL MODELS FOR STUDYING SICKLE-CELL DISEASE
    William King; Fiscal Year: 1980
    ..are to develop mathematical models and computer simulations to examine the interplay among microvasculature rheology, blood chemistry, oxygenation and red cell sickling, and to relate them to altered physiology of sickle-cell ..
  55. BLOOD SHUNT FOR ENZYMATIC MODIFICATION OF HEPARIN
    DEBRA TRANTOLO; Fiscal Year: 1991
    ..In this research, heparin is desulfated - a maneuver which alters the rheology and anticoagulant properties of the heparin...
  56. THE RHEOLOGY OF HUMAN CHORIOAMNIOTIC MEMBRANES
    J Lavery; Fiscal Year: 1980
    ..This will be an accumulative attempt to correlate physical and biochemical properties to appreciate the significant clinical problem of premature rupture of the human chorioamniotic sac...
  57. TUMOR TISSUES DURING HYPERTHERMIA AND HYPERGLYCEMIA
    Rakesh Jain; Fiscal Year: 1993
    ..In the proposed study, the role of red and white blood cell rheology in this flow modification will be determined...
  58. MSM-Multi-scale Analysis of Cellular Force Transmission and Biochemical Activatio
    Roger Kamm; Fiscal Year: 2007
    ..The prototypical problem is the simulation of cytoskeletal rheology and remodeling. Our specific aims are to: 1...
  59. Micromechanics of the airway smooth muscle cell
    Jeffrey Fredberg; Fiscal Year: 2009
    ..We propose to develop micromechanical technologies to measure cytoskeletal rheology, contractility, and remodeling...
  60. P20-Mediated Suppression of Vascular Force
    Christopher Rembold; Fiscal Year: 2004
    ..Many current treatments target smooth muscle to reduce tone. It is possible that targeting the force suppression pathway (i.e. p20) might provide comparable benefits. ..
  61. Effects of phosphoinositidies on cytoskeletal structure
    Paul Janmey; Fiscal Year: 2006
    ..abstract_text> ..
  62. MECHANICS OF ACUTE LUNG INJURY
    Jason Bates; Fiscal Year: 2009
    ..The results of our studies are expected to lead to the design of physiologically-based lung recruitment strategies that can be tailored to the individual patient with ALI. This will set the stage for future clinical trials. ..
  63. Novel antibacterial agents resistant to inactivation by polyelectrolytes
    Paul A Janmey; Fiscal Year: 2010
    ..The current proposal will create or retain 4 jobs. ..