relative biological effectiveness

Summary

Summary: The ratio of radiation dosages required to produce identical change based on a formula comparing other types of radiation with that of gamma or roentgen rays.

Top Publications

  1. ncbi Relative biological effectiveness of pulsed and continuous 20 MeV protons for micronucleus induction in 3D human reconstructed skin tissue
    Thomas E Schmid
    Department of Radiation Oncology, Technische Universitaet Muenchen, Germany
    Radiother Oncol 95:66-72. 2010
  2. ncbi Charged particles in radiation oncology
    Marco Durante
    Gesellschaft fur Schwerionenforschung GSI, Helmholtzzentrum für Schwerionenforschung, Biophysics Department, Plackstrasse 1, Darmstadt, Germany
    Nat Rev Clin Oncol 7:37-43. 2010
  3. ncbi Relative biological effectiveness (RBE) values for proton beam therapy
    Harald Paganetti
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 53:407-21. 2002
  4. ncbi LET-dependent survival of irradiated normal human fibroblasts and their descendents
    Nobuyuki Hamada
    Department of Quantum Biology, Division of Bioregulatory Medicine, Gunma University Graduate School of Medicine, Maebashi, Gunma 371 8511, Japan
    Radiat Res 166:24-30. 2006
  5. ncbi Quantification of the relative biological effectiveness for ion beam radiotherapy: direct experimental comparison of proton and carbon ion beams and a novel approach for treatment planning
    Thilo Elsasser
    Department of Biophysics, GSI Helmholtz Centre for Heavy Ion Research, Darmstadt, Germany
    Int J Radiat Oncol Biol Phys 78:1177-83. 2010
  6. ncbi RBE for carbon track-segment irradiation in cell lines of differing repair capacity
    W K Weyrather
    Gesellschaft fur Schwerionenforschung, Darmstadt, Germany
    Int J Radiat Biol 75:1357-64. 1999
  7. ncbi Relative biological effectiveness of the 235 MeV proton beams at the National Cancer Center Hospital East
    K Ando
    Clinical Radiation Biology and International Space Radiation Laboratory, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
    J Radiat Res 42:79-89. 2001
  8. ncbi Treatment planning for a scanned carbon beam with a modified microdosimetric kinetic model
    Taku Inaniwa
    Medical Physics Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
    Phys Med Biol 55:6721-37. 2010
  9. ncbi A mechanism-based approach to predict the relative biological effectiveness of protons and carbon ions in radiation therapy
    Malte C Frese
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Int J Radiat Oncol Biol Phys 83:442-50. 2012
  10. ncbi Relation between lineal energy distribution and relative biological effectiveness for photon beams according to the microdosimetric kinetic model
    Hiroyuki Okamoto
    Department of Energy Sciences, Tokyo Institute of Technology, Kanagawa, Japan
    J Radiat Res 52:75-81. 2011

Detail Information

Publications278 found, 100 shown here

  1. ncbi Relative biological effectiveness of pulsed and continuous 20 MeV protons for micronucleus induction in 3D human reconstructed skin tissue
    Thomas E Schmid
    Department of Radiation Oncology, Technische Universitaet Muenchen, Germany
    Radiother Oncol 95:66-72. 2010
    ....
  2. ncbi Charged particles in radiation oncology
    Marco Durante
    Gesellschaft fur Schwerionenforschung GSI, Helmholtzzentrum für Schwerionenforschung, Biophysics Department, Plackstrasse 1, Darmstadt, Germany
    Nat Rev Clin Oncol 7:37-43. 2010
    ..This Review considers the present clinical results in the field, and identifies and discusses the research questions that have resulted with this technique...
  3. ncbi Relative biological effectiveness (RBE) values for proton beam therapy
    Harald Paganetti
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 53:407-21. 2002
    Clinical proton beam therapy has been based on the use of a generic relative biological effectiveness (RBE) of 1.0 or 1...
  4. ncbi LET-dependent survival of irradiated normal human fibroblasts and their descendents
    Nobuyuki Hamada
    Department of Quantum Biology, Division of Bioregulatory Medicine, Gunma University Graduate School of Medicine, Maebashi, Gunma 371 8511, Japan
    Radiat Res 166:24-30. 2006
    ..confluent density-inhibited cultures were plated for primary colony formation, revealing that the relative biological effectiveness (RBE) based on the primary 10% survival dose peaked at 108 keV/microm and that the inactivation ..
  5. ncbi Quantification of the relative biological effectiveness for ion beam radiotherapy: direct experimental comparison of proton and carbon ion beams and a novel approach for treatment planning
    Thilo Elsasser
    Department of Biophysics, GSI Helmholtz Centre for Heavy Ion Research, Darmstadt, Germany
    Int J Radiat Oncol Biol Phys 78:1177-83. 2010
    ....
  6. ncbi RBE for carbon track-segment irradiation in cell lines of differing repair capacity
    W K Weyrather
    Gesellschaft fur Schwerionenforschung, Darmstadt, Germany
    Int J Radiat Biol 75:1357-64. 1999
    ..RBE values for cell inactivation at different survival levels were determined and the differences in the RBE-LET patterns were compared with the individual sensitivity to photon irradiation of the different cell lines...
  7. ncbi Relative biological effectiveness of the 235 MeV proton beams at the National Cancer Center Hospital East
    K Ando
    Clinical Radiation Biology and International Space Radiation Laboratory, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
    J Radiat Res 42:79-89. 2001
    ..The relative biological effectiveness (RBE) of protons obtained by comparing the D10 values between protons and X-rays ranged from 0...
  8. ncbi Treatment planning for a scanned carbon beam with a modified microdosimetric kinetic model
    Taku Inaniwa
    Medical Physics Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
    Phys Med Biol 55:6721-37. 2010
    We describe a method to calculate the relative biological effectiveness in mixed radiation fields of therapeutic ion beams based on the modified microdosimetric kinetic model (modified MKM)...
  9. ncbi A mechanism-based approach to predict the relative biological effectiveness of protons and carbon ions in radiation therapy
    Malte C Frese
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Int J Radiat Oncol Biol Phys 83:442-50. 2012
    ..In this work, an approach to predict proton and carbon ion relative biological effectiveness (RBE) in a representative spread-out Bragg peak (SOBP) is derived using the repair-misrepair-..
  10. ncbi Relation between lineal energy distribution and relative biological effectiveness for photon beams according to the microdosimetric kinetic model
    Hiroyuki Okamoto
    Department of Energy Sciences, Tokyo Institute of Technology, Kanagawa, Japan
    J Radiat Res 52:75-81. 2011
    ..As a result, the RBE of the photon beams (y(D): 2~5 keV/µm) in arbitrary conditions can be derived by the measurements only or the calculations only of the dose-mean lineal energy...
  11. ncbi LET dependency of heavy-ion induced apoptosis in V79 cells
    M Aoki
    Space and Particle Radiation Science Research Group, National Institute of Radiological Sciences, Chiba, Japan
    J Radiat Res 41:163-75. 2000
    ..13, and 0.24, respectively. A similar trend was found for the RBE values calculated from the initial slope for both apoptosis and reproductive death. These results strongly suggest that the target for both types of cell death is the same...
  12. ncbi Range uncertainty in proton therapy due to variable biological effectiveness
    Alejandro Carabe
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Phys Med Biol 57:1159-72. 2012
    ..The relative biological effectiveness (RBE) of protons is considered to vary with dose-averaged linear energy transfer (LET(d)), dose (d) ..
  13. pmc Phase I/II trial evaluating carbon ion radiotherapy for the treatment of recurrent rectal cancer: the PANDORA-01 trial
    Stephanie E Combs
    Deparment of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany
    BMC Cancer 12:137. 2012
    ..Moreover, in comparison to photons, carbon ions offer an increase relative biological effectiveness (RBE), which can be calculated between 2 and 5 depending on the cell line as well as the endpoint ..
  14. ncbi Comparison of biological effectiveness of carbon-ion beams in Japan and Germany
    Akiko Uzawa
    Heavy Ion Radiobiology Research Group, Research Center of Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 73:1545-51. 2009
    ..To compare the biological effectiveness of 290 MeV/amu carbon-ion beams in Chiba, Japan and in Darmstadt, Germany, given that different methods for beam delivery are used for each...
  15. pmc Randomized phase II study evaluating a carbon ion boost applied after combined radiochemotherapy with temozolomide versus a proton boost after radiochemotherapy with temozolomide in patients with primary glioblastoma: the CLEOPATRA trial
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    BMC Cancer 10:478. 2010
    ..Moreover, in comparison to photons, carbon ions offer an increase relative biological effectiveness (RBE), which can be calculated between 2 and 5 depending on the GBM cell line as well as the ..
  16. ncbi Effectiveness and safety of spot scanning proton radiation therapy for chordomas and chondrosarcomas of the skull base: first long-term report
    Carmen Ares
    Center for Proton Radiation Therapy, Paul Scherrer Institute, Villigen, Switzerland
    Int J Radiat Oncol Biol Phys 75:1111-8. 2009
    ..To evaluate effectiveness and safety of spot-scanning-based proton radiotherapy (PT) in skull-base chordomas and chondrosarcomas...
  17. ncbi Systematic review of experimental studies on the relative biological effectiveness of tritium
    M P Little
    Department of Epidemiology and Public Health, Imperial College, London W2 1PG, UK
    Radiat Environ Biophys 47:71-93. 2008
    ..review experimental data relating to tritium exposure with a view to assessing its low dose limiting relative biological effectiveness (RBE(max))...
  18. ncbi RBE of nearly monoenergetic neutrons at energies of 36 keV-14.6 MeV for induction of dicentrics in human lymphocytes
    E Schmid
    Institute of Radiobiology, GSF National Research Center for Environment and Health, P O Box 1129, 85764 Neuherberg, Germany
    Radiat Environ Biophys 42:87-94. 2003
    ..0 MeV. For the assessment of the relative biological effectiveness (RBE) both 220 kV x-rays and (60)Co gamma-rays were used as reference radiations...
  19. ncbi Biological characteristics of carbon-ion therapy
    Koichi Ando
    Medicine and Biology Division, Gunma University Heavy Ion Medical Center, Showa machi 3 39 22, Maebashi shi, Gunma, Japan
    Int J Radiat Biol 85:715-28. 2009
    ..A brief history of particle radiotherapy in the past half-century is followed by the reviewed biological effectiveness of high-LET charged particles...
  20. ncbi Accuracy of RBE: experimental and theoretical considerations
    T Friedrich
    GSI Helmholtzzentrum fur Schwerionenforschung, Planckstrasse 1, 64291 Darmstadt, Germany
    Radiat Environ Biophys 49:345-9. 2010
    The concept of the relative biological effectiveness (RBE) is essential for treatment planning in carbon ion therapy and for understanding the biological effects of high-LET radiation...
  21. ncbi Relative biological effectiveness of 280 keV neutrons for apoptosis in human lymphocytes
    L A Ryan
    McMaster University, Medical Physics and Applied Radiation Sciences Unit, 1280 Main St West, Hamilton, Ontario, Canada L8S 4K1
    Health Phys 91:68-75. 2006
    The relative biological effectiveness (RBE) of neutrons varies from unity to greater than ten depending upon neutron energy and the biological endpoint measured...
  22. ncbi Radiobiological evaluation and correlation with the local effect model (LEM) of carbon ion radiation therapy and temozolomide in glioblastoma cell lines
    Stephanie E Combs
    Department of Radiation Oncology, University of Heidelberg
    Int J Radiat Biol 85:126-37. 2009
    ..To investigate the cytotoxic effect of high linear-energy transfer (LET) carbon irradiation on glioblastoma cells lines in combination with temozolomide (TMZ)...
  23. ncbi Biologically effective dose values for prostate brachytherapy: effects on PSA failure and posttreatment biopsy results
    Richard G Stock
    Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Int J Radiat Oncol Biol Phys 64:527-33. 2006
    ..To analyze the effect of biologically effective dose (BED) values on prostate-specific antigen (PSA) failure and posttreatment biopsy...
  24. ncbi Relative biological effectiveness for cell-killing effect on various human cell lines irradiated with heavy-ion medical accelerator in Chiba (HIMAC) carbon-ion beams
    M Suzuki
    International Space Radiation Laboratory, National Institute of Radiological Sciences, Anagawa, Japan
    Int J Radiat Oncol Biol Phys 48:241-50. 2000
    To clarify the relative biological effectiveness (RBE) values of various human cell lines for carbon-ion beams with 2 different linear energy transfer (LET) beams and to investigate the relationship between the cell-killing effect and ..
  25. ncbi Toxicity and relative biological effectiveness of alpha emitting radioimmunoconjugates
    Jostein Dahle
    Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, 0310 Oslo, Norway
    Curr Radiopharm 4:321-8. 2011
    ..This review will provide a brief overview of the most promising radionuclides for targeted α-therapy and compare their relative biological effectiveness (RBE) and normal tissue toxicity.
  26. ncbi Induction and rejoining of DNA double-strand breaks in V79-4 mammalian cells following gamma- and alpha-irradiation
    T J Jenner
    Division of Radiobiological Mechanisms, MRC Radiobiology Unit, Chilton, Didcot, UK
    Int J Radiat Biol 64:265-73. 1993
    ..dependence of the initial yield of dsbs at 277 K on dose under aerobic conditions is linear with a relative biological effectiveness (RBE) for alpha-particles of 0.85 +/- 0.14 (sedimentation) and 0.68 +/- 0...
  27. ncbi Neutron energy-dependent initial DNA damage and chromosomal exchange
    K Tanaka
    International Radiation Information Center, Hiroshima University, Japan
    J Radiat Res 40:36-44. 1999
    ..RBE of low energy neutrons is higher than that of fission neutrons. Low energy neutrons containing Hiroshima atomic bomb radiation may have created a significantly higher incidence of biological effect in atomic bomb survivors...
  28. ncbi Preliminary calculation of RBE-weighted dose distribution for cerebral radionecrosis in carbon-ion treatment planning
    Yuki Kase
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba shi, Chiba 263 8555, Japan
    J Radiat Res 52:789-96. 2011
    ..The purpose of this study is to calculate the relative biological effectiveness (RBE) of carbon-ion beams on brain cells and to show RBE-weighted dose distributions for cerebral ..
  29. ncbi Differential effects of x-rays and high-energy 56Fe ions on human mesenchymal stem cells
    Kyle Kurpinski
    Department of Bioengineering, University of California Berkeley, Berkeley, CA, USA
    Int J Radiat Oncol Biol Phys 73:869-77. 2009
    ..This study was designed to compare the biological effects of X-rays and of high-linear energy transfer (LET) (56)Fe ions on human mesenchymal stem cells (hMSC)...
  30. ncbi Relative sensitivities of repair-deficient mammalian cells for clonogenic survival after alpha-particle irradiation
    Mark A Hill
    MRC Radiation and Genome Stability Unit, Harwell, Oxfordshire OX11 0RD, United Kingdom
    Radiat Res 162:667-76. 2004
    ....
  31. ncbi Biological effectiveness of (12)C and (20)Ne ions with very high LET
    Joanna Czub
    Institute of Physics, Jan Kochanowski University, ul Swietokrzyska 15, 25 406 Kielce, Poland
    Int J Radiat Biol 84:821-9. 2008
    To determine the relationship between the relative biological effectiveness (RBE) for cell inactivation and linear energy transfer (LET) in the Bragg peak region of (12)C and (20)Ne ions.
  32. ncbi LET and ion species dependence for cell killing in normal human skin fibroblasts
    Chizuru Tsuruoka
    International Space Radiation Laboratory, National Institute Radiological Sciences, Anagawa, Chiba, Japan
    Radiat Res 163:494-500. 2005
    ..These results suggest that the differences in the energy deposition track structures of the different ion sources have an effect on cell killing...
  33. ncbi Some implications of linear-quadratic-linear radiation dose-response with regard to hypofractionation
    Melvin Astrahan
    Department of Radiation Oncology, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, California 90033, USA
    Med Phys 35:4161-72. 2008
    ....
  34. ncbi Relative biological effectiveness of carbon ions for local tumor control of a radioresistant prostate carcinoma in the rat
    Peter Peschke
    Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center, Heidelberg, Germany
    Int J Radiat Oncol Biol Phys 79:239-46. 2011
    To study the relative biological effectiveness (RBE) of carbon ion beams relative to X-rays for local tumor control in a syngeneic rat prostate tumor (Dunning subline R3327-AT1).
  35. ncbi Changes of fibrosis-related parameters after high- and low-LET irradiation of fibroblasts
    C Fournier
    GSI Biophysics, Planckstrasse 1, D 64291 Darmstadt, Germany
    Int J Radiat Biol 77:713-22. 2001
    ..To investigate the radiation-induced, premature terminal differentiation and collagen production of fibroblasts after heavy ion irradiation. These endpoints are discussed as an underlying cellular mechanism of fibrosis...
  36. ncbi A microdosimetric-kinetic model for the effect of non-Poisson distribution of lethal lesions on the variation of RBE with LET
    Roland B Hawkins
    Radiation Oncology Center, Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
    Radiat Res 160:61-9. 2003
    ..An equation based on the MK model is presented which gives the dependence of the relative biological effectiveness in the limit of zero dose (RBE1) on the linear energy transfer (LET)...
  37. ncbi The increased biological effectiveness of heavy charged particles: from radiobiology to treatment planning
    M Kramer
    GSI Biophysics, Planckstrasse 1, D 64291 Darmstadt
    Technol Cancer Res Treat 2:427-36. 2003
    ..Finally, the implementation of the biophysical model in the treatment planning procedure is presented. The biological verification of the whole treatment planning procedure is explained and examples of patient treatment plans are given...
  38. ncbi Examination of GyE system for HIMAC carbon therapy
    Tatsuaki Kanai
    Department of Medical Physics, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 64:650-6. 2006
    ....
  39. ncbi A phenomenological model for the relative biological effectiveness in therapeutic proton beams
    J J Wilkens
    German Cancer Research Center DKFZ, Department of Medical Physics, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Phys Med Biol 49:2811-25. 2004
    To study the effects of a variable relative biological effectiveness (RBE) in inverse treatment planning for proton therapy, fast methods for three-dimensional RBE calculations are required...
  40. ncbi Radiobiological characterization of proton beam at the National Cancer Center in Korea
    Hye Jung Baek
    Radiation Medicine Branch, National Cancer Center, Goyang, Korea
    J Radiat Res 49:509-15. 2008
    Estimation of the relative biological effectiveness (RBE) of the proton beam at the National Cancer Center Proton Therapy Center in Korea (NCCPTC) is required clinically for the treatment of cancer...
  41. ncbi Radiobiology with heavy charged particles: a historical review
    L D Skarsgard
    Department of Medical Biophysics, B C Cancer Research Centre, Vancouver, Canada
    Phys Med 14:1-19. 1998
    ..One of the earliest systematic studies of the dependence of RBE (relative biological effectiveness) and OER (oxygen enhancement ratio) on LET (linear energy transfer) was that by Barendsen in the ..
  42. ncbi Spread-out antiproton beams deliver poor physical dose distributions for radiation therapy
    Harald Paganetti
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Radiother Oncol 95:79-86. 2010
    ..Previous studies have focused on small-diameter near-monoenergetic antiproton beams. The goal of this work was to study more clinically relevant beams...
  43. ncbi The relationship between the RBE of alpha particles and the radiosensitivity of different mutations of Chinese hamster cells
    N A Zyuzikov
    Department of Radiation Biology, St. Bartholomew's and the Royal London School of Medicine and Dentistry, UK
    Radiat Environ Biophys 40:243-8. 2001
    ..Since cells with different defects of repair or cell cycle control have different radiosensitivities, we conclude that the effects of x-ray irradiation and the RBE are mostly determined by the activity of repair processes...
  44. ncbi Relative biological effectiveness and cell-killing efficacy of continuous low-dose-rate 125I seeds on prostate carcinoma cells in vitro
    Anyan Liao
    Peking University 3rd Hospital Beijing, China
    Integr Cancer Ther 9:59-65. 2010
    ..The relative biological effectiveness of (125)I seeds on PC3 cells with respect to (60)Co gamma rays was 1.4...
  45. ncbi Relative biological effectiveness of accelerated heavy ions for induction of morphological transformation in Syrian hamster embryo cells
    Z B Han
    Radiation Biology Center, Kyoto University, Japan
    J Radiat Res 39:193-201. 1998
    ..The relative biological effectiveness (RBE) of the heavy ions relative to X-rays first increased with LET, reached a maximum value of ..
  46. ncbi Simultaneous exposure of mammalian cells to heavy ions and X-rays
    Y Furusawa
    National Institute of Radiological Sciences, Chiba, Japan
    Adv Space Res 30:877-84. 2002
    ..A small deviation from a simple additive function is observed with very high-LET iron ions combined to X-rays...
  47. ncbi How low is the alpha/beta ratio for prostate cancer? In regard to Wang et al., IJROBP 2003;55:194-203
    Jack F Fowler
    Int J Radiat Oncol Biol Phys 57:593-5; author reply 595-6. 2003
  48. ncbi Clinical consequences of relative biological effectiveness variations in proton radiotherapy of the prostate, brain and liver
    Alejandro Carabe
    Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA19104, USA
    Phys Med Biol 58:2103-17. 2013
    Proton relative biological effectiveness (RBE) is known to depend on the (α/β)x of irradiated tissues, with evidence of ∼60% variation over (α/β)x values from 1-10 Gy. The range of (α/β)x values reported for prostate tumors (1...
  49. ncbi Relative biological effectiveness of mammography X-rays at the level of DNA and chromosomes in lymphocytes
    Julie Depuydt
    Department of Basic Medical Sciences, University of Ghent, Belgium
    Int J Radiat Biol 89:532-8. 2013
    ..In order to assess the benefit/risk ratio of those programs the relative biological effectiveness (RBE) of mammography X-rays needs to be determined.
  50. ncbi Sensitivity analysis of the relative biological effectiveness predicted by the local effect model
    T Friedrich
    GSI Helmholtzzentrum fur Schwerionenforschung, Darmstadt, Germany
    Phys Med Biol 58:6827-49. 2013
    The relative biological effectiveness (RBE) is a central quantity in particle radiobiology and depends on many physical and biological factors...
  51. ncbi Comparison of optimized single and multifield irradiation plans of antiproton, proton and carbon ion beams
    Niels Bassler
    Dept of Experimental Clinical Oncology, Aarhus University Hospital, Arhus, Denmark
    Radiother Oncol 95:87-93. 2010
    ..However, concerns are expressed about the inferior lateral dose distribution caused by the annihilation products...
  52. ncbi Dose response and kinetics of foci disappearance following exposure to high- and low-LET ionizing radiation
    Rasa Ugenskiene
    Department of Radiation Biology, Centre for Cancer Research and Cell Biology, Queen s University Belfast, Belfast, UK
    Int J Radiat Biol 85:872-82. 2009
    ..The effect of different radiation qualities on (i) 53BP1 (p53 Binding Protein 1) and p-ATM (phosphorylated ataxia telangiectasia mutated) foci induction, and (ii) on the kinetics of foci disappearance was analysed...
  53. ncbi A radiobiological model for the relative biological effectiveness of high-dose-rate 252Cf brachytherapy
    Mark J Rivard
    Department of Radiation Oncology, Tufts New England Medical Center, Boston, MA 02111, USA
    Radiat Res 164:319-23. 2005
    ..low- and high-dose-rate 252Cf brachytherapy, there are minimal data regarding values for the neutron relative biological effectiveness (RBE) with both modalities...
  54. ncbi In vitro RBE-LET dependence for multiple particle types
    Brita Singers Sørensen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Acta Oncol 50:757-62. 2011
    ..The aim of the present study is to summarize the available data in the literature regarding the dependency of RBE on LET for different particles...
  55. ncbi Relative biological effectiveness of high linear energy transfer α-particles for the induction of DNA-double-strand breaks, chromosome aberrations and reproductive cell death in SW-1573 lung tumour cells
    Nicolaas A P Franken
    Department of Radiation Oncology, Laboratory for Experimental Oncology and Radiobiology LEXOR, Centre for Experimental Molecular Medicine, University of Amsterdam, P O Box 22700, 1100 DE Amsterdam, The Netherlands
    Oncol Rep 27:769-74. 2012
    ..This suggests possible relevance to assess RBE values for radiotherapy with high LET ions...
  56. ncbi Carbon-ion radiotherapy for locally advanced or unfavorably located choroidal melanoma: a Phase I/II dose-escalation study
    Hiroshi Tsuji
    Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 67:857-62. 2007
    ..To evaluate the applicability of carbon ion beams for the treatment of choroidal melanoma with regard to normal tissue morbidity and local tumor control...
  57. ncbi Relative biological effectiveness of 144 keV neutrons in producing dicentric chromosomes in human lymphocytes compared with 60Co gamma rays under head-to-head conditions
    E Schmid
    Institute of Radiobiology, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Radiat Res 157:453-60. 2002
    ..Consequently, alpha(dic) values cannot be shared between cytogenetic laboratories for the purpose of assessment of RBM(m) without verification of the comparability of the experimental conditions...
  58. ncbi Inactivation and mutation induction in V79 cells by low energy protons: re-evaluation of the results at the LNL facility
    M Belli
    Laboratori Nazionali di Legnaro INFN, Padova, Italy
    Int J Radiat Biol 63:331-7. 1993
    ..In spite of that, the extent of the changes is not such as to modify the general conclusion previously drawn, pointing out that there is a LET range where protons are more effective than alpha-particles...
  59. ncbi Relative biological effectiveness of 290 MeV/u carbon ions for the growth delay of a radioresistant murine fibrosarcoma
    Sachiko Koike
    Heavy Ion Radiobiology Research Group, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 5555, Japan
    J Radiat Res 43:247-55. 2002
    The relative biological effectiveness (RBE) for animal tumors treated with fractionated doses of 290 MeV/u carbon ions was studied...
  60. ncbi Relative biological effectiveness (RBE) of alpha radiation in cultured porcine aortic endothelial cells
    Patricia Thomas
    Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan
    Int J Radiat Biol 83:171-9. 2007
    ..The relative biological effectiveness (RBE) of alpha particles vs...
  61. ncbi Radiopharmaceuticals for nuclear cardiology: radiation dosimetry, uncertainties, and risk
    Michael G Stabin
    Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee 37232 2675, USA
    J Nucl Med 49:1555-63. 2008
    ..Also discussed is the issue of uncertainties in radiation dose estimates and how to compare the relative risks of studies...
  62. ncbi Early and delayed reproductive death in human cells exposed to high energy iron ion beams
    D Bettega
    Dipartimento di Fisica, Universita degli Studi di Milano and INFN Sezione di Milano, Milano, Italy
    Adv Space Res 35:280-5. 2005
    ..The relative biological effectiveness at low doses of the iron beams is highest for LET values between 140 and 200 keV/micrometers with ..
  63. ncbi The radiobiology of prostate cancer including new aspects of fractionated radiotherapy
    Jack F Fowler
    Emeritus of Medical School of Wisconsin University, Department of Human Oncology, University of Wisconsin Madison, USA
    Acta Oncol 44:265-76. 2005
    ..Monotherapy by brachytherapy for low-risk cancer prostate using two to four fractions in a few days can give even higher biological effects on the tumors...
  64. ncbi Relative biological effectiveness of boron ions on human melanoma cells
    L M Persson
    Medical Radiation Physics, Department of Oncology Pathology, Karolinska Institutet and Stockholm University, Box 260, SE 171 76 Stockholm, Sweden
    Int J Radiat Biol 78:743-8. 2002
    To compare the difference in relative biological effectiveness (RBE) between (10)B ions and a (60)Co gamma-ray beam for human melanoma cells using in vitro cell survival based on a clonogenic assay.
  65. ncbi Temporal lobe reactions after radiotherapy with carbon ions: incidence and estimation of the relative biological effectiveness by the local effect model
    Ingmar Schlampp
    Department of Radiation Oncology, University of Heidelberg, Germany
    Int J Radiat Oncol Biol Phys 80:815-23. 2011
    ....
  66. ncbi The general relation between tissue response to x-radiation (alpha/beta-values) and the relative biological effectiveness (RBE) of protons: prediction by the Katz track-structure model
    H Paganetti
    Department of Radiation Oncology, Massachusetts General Hospital, Boston 02114, USA
    Int J Radiat Biol 76:985-98. 2000
    Experimental data suggest that the relative biological effectiveness (RBE) of protons compared to x-rays may be determined by the alpha/beta-ratio of the x-ray survival curve...
  67. pmc Monte Carlo simulation of irradiation and killing in three-dimensional cell populations with lognormal cellular uptake of radioactivity
    Roger W Howell
    Department of Radiology, Division of Radiation Research, University of Medicine and Dentistry of New Jersey New Jersey Medical School Cancer Center, Newark, NJ 07103, USA
    Int J Radiat Biol 88:115-22. 2012
    ..The present work develops theoretical models to simulate these observations...
  68. ncbi Microdosimetric study on influence of low energy photons on relative biological effectiveness under therapeutic conditions using 6 MV linac
    Hiroyuki Okamoto
    Department of Energy Sciences, Tokyo Institute of Technology, Kanagawa 226 8502, Japan
    Med Phys 38:4714-22. 2011
    ..In this study, the changes of the relative biological effectiveness (RBE) values under the therapeutic conditions using a 6 MV linac were investigated with a ..
  69. pmc The apparent increase in the {beta}-parameter of the linear quadratic model with increased linear energy transfer during fast neutron irradiation
    B Jones
    Gray Institute for Radiation Oncology and Biology, University of Oxford, Headington, UK
    Br J Radiol 83:433-6. 2010
    ..These interesting findings after fast neutron exposure need to be studied further for applications in charged particle beam therapy using light ions, which is presently undergoing a worldwide expansion...
  70. ncbi Measurement of biological effects of high-energy carbon ions at low doses using a semi-automated cell detection system
    G Böhrnsen
    Radiobiology Section, Department of Radiotherapy, University of Heidelberg, In Neuenheimer Feld 400, D 69120 Heidelberg, Germany
    Int J Radiat Biol 78:259-66. 2002
    ..To study the effects of low-dose, high-LET irradiation in order to detect possible deviations from a linear-quadratic dose dependence...
  71. ncbi Microdosimetry spectra of the Loma Linda proton beam and relative biological effectiveness comparisons
    G Coutrakon
    Department of Radiation Medicine, Loma Linda University Medical Center, California 92354, USA
    Med Phys 24:1499-506. 1997
    ..However, a detailed account of LET (linear energy transfer) and RBE (relative biological effectiveness) changes with incident beam energy and depth in tissue is still unresolved...
  72. ncbi Preclinical biological assessment of proton and carbon ion beams at Hyogo Ion Beam Medical Center
    Kazufumi Kagawa
    Department of Radiology, Hyogo Ion Beam Medical Center, Hyogo, Japan
    Int J Radiat Oncol Biol Phys 54:928-38. 2002
    ..To assess the biologic effects of proton and carbon ion beams before clinical use...
  73. ncbi Field size effect of radiation quality in carbon therapy using passive method
    H Nose
    Advanced Applied Science Department, Research Laboratory, IHI Corporation, 1 Shin Nakahara Cho, Isogo ku, Yokohama 235 8501, Japan
    Med Phys 36:870-5. 2009
    ..Because such a tendency appeared to be more remarkable in the deeper region of the water phantom, it is likely that fragment particles that are born in a water phantom have a marked role in determining the field size effect...
  74. ncbi The impact of possible modifications to the DS86 dosimetry on neutron risk and relative biological effectiveness
    Nezahat Hunter
    National Radiological Protection Board, Chilton, Oxon OX11 0RQ, UK
    J Radiol Prot 22:357-70. 2002
    ..The impact on the evaluation of neutron relative biological effectiveness (RBE) and gamma radiation risk estimates has been assessed...
  75. ncbi Treatment planning intercomparison for spinal chordomas using intensity-modulated photon radiation therapy (IMRT) and carbon ions
    D Schulz-Ertner
    Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
    Phys Med Biol 48:2617-31. 2003
    ..A combination of carbon ions and photon IMRT might be preferable in order to profit by the physical advantages of carbon ions while ensuring a safe treatment...
  76. ncbi Dose-response and relative biological effectiveness of fast neutrons: induction of apoptosis and inhibition of neurogenesis in the hippocampus of adult mice
    Miyoung Yang
    Department of Veterinary Anatomy, College of Veterinary Medicine, Chonnam National University, Buk Gu, Gwangju, South Korea
    Int J Radiat Biol 86:476-85. 2010
    ..apoptosis and reduction of neurogenesis in the hippocampus of adult ICR mice with those of low-LET (60)Co gamma-rays, to evaluate the relative biological effectiveness (RBE) of fast neutrons in the adult hippocampal dentate gyrus (DG).
  77. ncbi Significance and implementation of RBE variations in proton beam therapy
    H Paganetti
    Massachusetts General Hospital, Department of Radiation Oncology and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Technol Cancer Res Treat 2:413-26. 2003
    ..To optimize treatment for ion therapy not the dose but the dose multiplied by the relative biological effectiveness (RBE) is decisive...
  78. ncbi The relative biological effectiveness of densely ionizing heavy-ion radiation for inducing ocular cataracts in wild type versus mice heterozygous for the ATM gene
    Eric J Hall
    Center for Radiological Research, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA
    Radiat Environ Biophys 45:99-104. 2006
    ..In this paper we derive quantitative estimates for the relative biological effectiveness (RBE) of high energy (56)Fe ions compared with X-rays, both for wild type and for mice ..
  79. ncbi Relative biological effectiveness (RBE) of 210Po alpha-particles versus X-rays on lethality in bovine endothelial cells
    P A Thomas
    Toxicology Centre, University of Saskatchewan, 44 Campus Drive, Saskatoon, Saskatchewan, Canada S7N 5B3
    Int J Radiat Biol 79:107-18. 2003
    ..This study examined the relative biological effectiveness (RBE) of (210)Po alpha-particles versus 250 kVp X-rays in producing injury to cultured bovine aortic ..
  80. ncbi AT cells show dissimilar hypersensitivity to heavy-ion and X-rays irradiation
    Shoichiro Kitajima
    Central Laboratory and Radiation Biology, Aichi Cancer Center Research Institute, Nagoya 464 8681, Japan
    J Radiat Res 51:251-5. 2010
    ..In normal cells the RBE (relative biological effectiveness) of carbon and iron ions increased from 1.19 to 1.81 in proportion to LET...
  81. ncbi Heavy-ion induced chromosomal aberrations: a review
    Sylvia Ritter
    GSI Helmholtzzentrum fur Schwerionenforschung, Biophysics Department, Planckstrasse 1, 64291 Darmstadt, Germany
    Mutat Res 701:38-46. 2010
    ..The relative biological effectiveness for the induction of cytogenetic damage is strongly dependent on the time between irradiation and ..
  82. ncbi The effectiveness of 20 mev protons at nanosecond pulse lengths in producing chromosome aberrations in human-hamster hybrid cells
    T E Schmid
    Klinikum rechts der Isar, Department of Radiation Oncology, Technische Universitat Munchen, D 81675 Munchen, Germany
    Radiat Res 175:719-27. 2011
    ....
  83. ncbi Effect of edema, relative biological effectiveness, and dose heterogeneity on prostate brachytherapy
    Jian Z Wang
    Department of Radiation Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Med Phys 33:1025-32. 2006
    ..Among them, edema, relative biological effectiveness (RBE), and dose heterogeneity have not been fully modeled previously...
  84. ncbi The U.S. National Research Council's views of the radiation hazards in space
    R B Setlow
    Biology Department, Brookhaven National Laboratory, Box 5000, Upton, NY 11973 5000, USA
    Mutat Res 430:169-75. 1999
    ....
  85. ncbi Experimental derivation of relative biological effectiveness of A-bomb neutrons in Hiroshima and Nagasaki and implications for risk assessment
    M S Sasaki
    Radiation Biology Center, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Radiat Res 170:101-17. 2008
    ..remains in the equivalent dose, because it is generally believed that direct derivation of the relative biological effectiveness (RBE) of neutrons from the epidemiological data on the survivors is difficult...
  86. ncbi The radiobiological effectiveness of carbon-ion beams on growing neurons
    Wael S Al-Jahdari
    Department of Radiation Oncology, Gunma University Graduate School of Medicine, Gunma, Japan
    Int J Radiat Biol 85:700-9. 2009
    ..However, the biological effect of carbon-ion beams arising on normal neuron remains unknown. Therefore, this study was undertaken to investigate the effect of carbon-ion beams on neurons by using both morphological and functional assays...
  87. ncbi Dose-response and large relative biological effectiveness of fast neutrons with regard to mouse fetal cerebral neuron apoptosis
    Yuka Ishida
    Low Dose Radiation Effects Research Project, National Institute of Radiological Sciences, Chiba, Japan
    J Radiat Res 47:41-7. 2006
    To evaluate the relative biological effectiveness (RBE) of low doses of neutrons on fetal nervous development, [C57BL/6J x C3H/He] hybrid (B6C3F1) mice were exposed to cyclotron-derived fast neutrons with peak energy of 10 MeV (0.02-1...
  88. pmc Conventional and CT angiography in children: dosimetry and dose comparisons
    Donald P Frush
    Division of Pediatric Radiology, Department of Radiology, Duke University Medical Center, 1905 McGovern Davison Children s Health Center, PO Box DUMC 3808, Durham 27710, NC, USA
    Pediatr Radiol 36:154-8. 2006
    ..It is with these dose data that assessment of risks, and ultimately the assessment of risk-benefit, can be better achieved...
  89. ncbi Relative biological effectiveness enhancement of a 125I brachytherapy seed with characteristic x rays from its constitutive materials
    Richard Taschereau
    Centre Hospitalier Universitaire de Quebec, Département de Radio Oncologie, Canada
    Med Phys 29:1397-402. 2002
    ..The purpose of this study is to investigate how characteristic x rays may be used to raise the relative biological effectiveness (RBE) of an iodine seed at short distances to increase the differential effect between tumor and ..
  90. ncbi Relative biological effectiveness of 103Pd and 125I photons for continuous low-dose-rate irradiation of Chinese hamster cells
    Ravinder Nath
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Radiat Res 163:501-9. 2005
    ..For the CCL-16 cells, the RBE of 103Pd at 19.0 cGy/h relative to that of 125I at 6.9 cGy/h was estimated to be 2.3 +/- 0.5...
  91. ncbi Rapid calculation of biological effects in ion radiotherapy
    M Kramer
    GSI Biophysik, Planck Str 1, D 64291 Darmstadt, Germany
    Phys Med Biol 51:1959-70. 2006
    ..This will allow sophisticated methods of treatment planning for ion irradiation, taking biological effects fully into account...
  92. ncbi Absolute and relative dose-surface and dose-volume histograms of the bladder: which one is the most representative for the actual treatment?
    Mischa S Hoogeman
    Department of Radiation Oncology, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Phys Med Biol 50:3589-97. 2005
    ..We found that the absolute dose-surface histogram was the most representative one for the actual treatment...
  93. ncbi Shielding of relativistic protons
    A Bertucci
    Department of Biology, University Federico II, Monte S Angelo, Via Cintia, 80126 Napoli, Italy
    Radiat Environ Biophys 46:107-11. 2007
    ..albeit secondary protons are slower than incident nuclei, the LET spectrum is still contained in the low-LET range (<10 keV/microm), which explains the approximately unitary value measured for the relative biological effectiveness.
  94. ncbi The EPRI EDE calculator--a software package for assessing effective dose equivalent from hot particles on the skin
    X George Xu
    Nuclear Engineering and Engineering Physics, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
    Health Phys 91:373-8. 2006
    ..1 MeV and 2 MeV for point sources at 74 locations on the skin. This technical note describes a software package called the EPRI EDE Calculator that allows a user to input exposure data and to calculate the EDE and ED automatically...
  95. ncbi Aircrew dosimetry using the Predictive Code for Aircrew Radiation Exposure (PCAIRE)
    B J Lewis
    Department of Chemistry and Chemical Engineering, Royal Military College of Canada, P O Box 17000, Stn Forces, Kingston, Ontario, Canada K7K 7B4
    Radiat Prot Dosimetry 116:320-6. 2005
    ..This model has been used to determine the significance of SEP exposure on a theoretical jet altitude flight during GLE 42...
  96. ncbi Investigation of geometrical and scoring grid resolution for Monte Carlo dose calculations for IMRT
    B De Smedt
    Department of Medical Physics, Ghent University, Proeftuinstraat 86, B 9000 Gent, Belgium
    Phys Med Biol 50:4005-19. 2005
    ..The scoring grid provides an additional degree of freedom for limiting calculation time and memory requirements by selecting optimized scoring and geometrical voxel dimensions in an independent way...
  97. ncbi Dosimetric and microdosimetric study of contrast-enhanced radiotherapy with kilovolt x-rays
    Frank Verhaegen
    Medical Physics Department, McGill University Health Centre, Montreal General Hospital, 1650 Cedar Avenue, Montreal, Quebec, H3G 1A4, Canada
    Phys Med Biol 50:3555-69. 2005
    ..It is concluded that kV-CERT is a promising radiotherapy technique, provided contrast medium can be delivered reliably to tumours...
  98. ncbi Improving IMRT delivery efficiency using intensity limits during inverse planning
    Martha M Coselmon
    Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Med Phys 32:1234-45. 2005
    ..Constraining the maximum intensity in an inverse IMRT plan is a simple way to improve delivery efficiency without compromising plan objectives...
  99. ncbi Advantages of inflatable multichannel endorectal applicator in the neo-adjuvant treatment of patients with locally advanced rectal cancer with HDR brachytherapy
    Slobodan Devic
    Medical Physics Department, McGill University Health Centre, Montreal, Quebec, H3G 1A4, Canada
    J Appl Clin Med Phys 6:44-9. 2005
    ..Our results justify the advantage of using a multichannel endorectal brachytherapy applicator as a neo-adjuvant treatment of patients with locally advanced rectal cancer...
  100. ncbi A Monte Carlo based method to estimate radiation dose from multidetector CT (MDCT): cylindrical and anthropomorphic phantoms
    J J DeMarco
    David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Phys Med Biol 50:3989-4004. 2005
    ..Future work will be extended to voxelized patient models of different sizes and to other MDCT scanners...
  101. ncbi A numerical evaluation of SAR distribution and temperature changes around a metallic plate in the head of a RF exposed worker
    Robert L McIntosh
    Telstra Research Laboratories, Clayton, Australia
    Bioelectromagnetics 26:377-88. 2005
    ....

Research Grants62

  1. Evaluation of Tritium: Relative Biological Effectiveness and Cancer Mortality
    David B Richardson; Fiscal Year: 2011
    ..Radiation protection standards assign a relative biological effectiveness (RBE) of 1 for beta-emitters compared to gamma-emitters...
  2. TOPAS: Fast and easy to use Monte Carlo system for proton therapy
    Harald Paganetti; Fiscal Year: 2013
    ..Provide a framework for cellular effect RBE modeling b. Validate by calculating the relative biological effectiveness f proton beams Specific Aim 3: Expand TOPAS to facilitate research on sub-cellular effect biology a...
  3. AM-241 APPLICATORS FOR INTRACAVITARY IRRADIATION
    Ravinder Nath; Fiscal Year: 1990
    ..b>Relative biological effectiveness (RBE) of Am-241 photons as compared with Ir-192 and I-125 photons will be determined in a rat solid ..
  4. Liposome Delivery of Boron for BNCT
    M Hawthorne; Fiscal Year: 2007
    ..of the three tumor models will be determined in irradiation experiments at the MIT Reactor; RBE (relative biological effectiveness) and CBE (compound biological effectiveness) factor values will be determined...
  5. MENTORED PATIENT ORIENTED RESEARCH CAREER DEVELOPMENT AW
    John Sampson; Fiscal Year: 2004
    ..biostability and the use of high linear energy transfer radioisotopes, such as (211)At, with greater relative biological effectiveness. The hypothesis to be tested in this proposal is that continuous microinfusion will widely deliver ..
  6. Intracerebral Infusion of Radiolabeled Specific Antibody
    John Sampson; Fiscal Year: 2006
    ..biostability and the use of high linear energy transfer radioisotopes, such as 211-At, with greater relative biological effectiveness.The hypothesis to be tested in this proposal is that continuous microinfusion will widely deliver ..
  7. EFFECTS OF LOW ENERGY ELECTRONS FROM AUGER PROCESSES
    DANDAMUDI RAO; Fiscal Year: 1990
    ..Comparison with the effects of beta-decaying radionuclides of the same element give the relative biological effectiveness (RBE) of the incorporated EC and IC radionuclides...
  8. RADIATION INDUCED CHROMOSOME DAMAGE IN VIVO
    ANTONE BROOKS; Fiscal Year: 1991
    ..First, what is the relative biological effectiveness of protracted high and low LET radiation for the induction of chromosome aberrations from internally ..
  9. RADIOLOGICAL STUDIES RELATED TO HIGH LET RADIOTHERAPY
    Eric Hall; Fiscal Year: 1990
    ..Well tried radiobiological systems will be employed to compare the relative biological effectiveness (RBE) of the new generation of hospital based neutron generators in the United States...
  10. CANCER AND INJURY RISK ASSESSMENT FOR RADIONUCLIDES
    OTTO RAABE; Fiscal Year: 1992
    ..and their inter-relationship, influence of radiation quality factor (Q) with respect to observed relative biological effectiveness (RBE), relative dose-rate effectiveness factor, route and mode of exposure including single acute, ..
  11. High Stability Accelerator for Sub-Cellular Microbeam
    David Brenner; Fiscal Year: 2003
    ..We have considerably more demand for microbeam time than we can cope with, primarily because of limited physicist manpower. ..
  12. Cancer Risks Attributable To Radiation from Pediatric CT
    David Brenner; Fiscal Year: 2006
    ..The target audiences will be radiologists, pediatricians, family physicians, and the CT industry. We will use telephone interviews supplemented with survey questions, to aid in web content decisions. ..
  13. RADIOLOGICAL RESEARCH ACCELERATOR FACILITY (RARAF)
    David Brenner; Fiscal Year: 2002
    ..abstract_text> ..
  14. 4D Visible Human Modeling for Radiation Dosimetry
    Xie George Xu; Fiscal Year: 2010
    ..4).To establish an internet-based information-sharing resource on virtual-human motion simulation and radiation dosimetry. ..
  15. Virtual Patients for Computing Radiation Doses
    Xie Xu; Fiscal Year: 2007
    ..These two cores then support four parallel clinical projects. [unreadable] [unreadable] [unreadable]..
  16. Targeted Alpha-Particle Emitter Therapy of Metastases
    George Sgouros; Fiscal Year: 2009
    ..The work described in this application is intended to develop and evaluate such an approach. ..
  17. MODELING AND DOSIMETRY FOR RADIOLABELED ANTIBODY THERAPY
    George Sgouros; Fiscal Year: 2002
    ....
  18. Non-Invasive Localization of Vulnerable Plaques
    Cynthia McCollough; Fiscal Year: 2009
    ....
  19. Radiopharmaceutical Dosimetry Symposium
    Michael Stabin; Fiscal Year: 2002
    ..abstract_text> ..
  20. Realistic Phantom Series for OLINDA/EXM Version 2
    Michael Stabin; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  21. New Methods for Improved Image-based Dosimetry
    Michael Stabin; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  22. Measurement of pO2 in tissues in vivo and in vitro
    Harold Swartz; Fiscal Year: 2006
    ....
  23. Advances in Skeletal Dosimetry Through Microimaging
    Wesley Bolch; Fiscal Year: 2006
    ..abstract_text> ..
  24. Determination of Clinical Feasibility of EPR Oximetry of Tumors
    Harold Swartz; Fiscal Year: 2007
    ..Determining the feasibility of continuous measurements for up to 120 minutes. [unreadable] [unreadable] [unreadable]..
  25. Chemotherapy with injectable microdroplets
    FRANCESCO D ERRICO; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  26. BioDose-08 Conference
    Harold Swartz; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  27. EFFECTS OF NONUNIFORM DISTRIBUTIONS OF RADIOACTIVITY
    Roger Howell; Fiscal Year: 2009
    ..Finally, to initiate transition of our multicellular dosimetry approach to in vivo, we will carry out bystander studies in mouse testis. ..
  28. Gamma Ray Spectroscopy for Dose Rate Constants
    Ravinder Nath; Fiscal Year: 2006
    ..abstract_text> ..
  29. DOSIMETRY OF BRACHYTHERAPY SOURCES IN MILLIMETER RANGE
    Ravinder Nath; Fiscal Year: 2003
    ..The goals of the project are to develop tools for the optimization of dose distributions produced within a target volume and uniformity of dose along and around a blood vessel. ..
  30. TOMOGRAPHIC DOSIMETRY PHANTOMS FOR PEDIATRIC RADIOLOGY
    Wesley Bolch; Fiscal Year: 2002
    ....
  31. Near infrared/MR system for imaging brain oxygenation
    Harold Swartz; Fiscal Year: 2004
    ..This grant will produce a novel imaging modality which can non-invasively monitor cerebral oxygenation, structure, and blood flow. ..
  32. SUPERHEATED DROP DETECTORS FOR DOSIMETRY IN RADIOTHERAPY
    Ravinder Nath; Fiscal Year: 2005
    ..A Petri-dish-like micro SEC will be developed for the determination of doses at the interface of high Z materials and tissues with capability of measuring doses averaged over layers of about 10 pm thickness. ..
  33. SUPERHEATED DROP DETECTORS FOR DOSIMETRY IN RADIOTHERAPY
    Ravinder Nath; Fiscal Year: 2001
    ..The research plan will attempt to exploit the many unique features of the SEC, namely its reusability, high sensitivity and LET discrimination. ..
  34. TOMOGRAPHIC DOSIMETRY PHANTOMS FOR PEDIATRIC RADIOLOGY
    Wesley Bolch; Fiscal Year: 2001
    ....
  35. NABTC (UCSF PROJECT LEADER) U OF WISCONSIN
    Minesh Mehta; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  36. IOWA AND MISSOURI RADON LUNG CANCER STUDIES
    R Field; Fiscal Year: 2007
    ..The pooling of data between two large-scale epidemiologic studies from a similar geographic area, Iowa and Missouri, will allow us to increase sample size and statistical power. ..
  37. Breast CT scanner for earlier cancer detection
    John Boone; Fiscal Year: 2002
    ..that particularly warrant screening using breast CT. The Phase II trial will shed more light on this issue. ..
  38. DEVELOPMENT OF A GERMANIUM PHOTON IMAGING DETECTOR
    AARON BRILL; Fiscal Year: 2001
    ..The team includes scientists, medical and industrial workers skilled in the relevant technology. ..
  39. 2008 Engineering in Medicine and Biology Conference (EMBC)
    Paolo Vicini; Fiscal Year: 2008
    ..The intent of this is to broaden participation by junior scientists in the scientific activities of this large international meeting. [unreadable] [unreadable] [unreadable]..
  40. MONTE CARLO SIMULATION OF HIGH ENERGY PHOTON IMAGING
    Yuni Dewaraja; Fiscal Year: 2001
    ..Apart from quantification, this work will have applications in the design of future imaging systems for high energy photons. ..
  41. Biological Predictors of Response to Antidepressants
    Ramin V Parsey; Fiscal Year: 2010
    ..Our overall goal is to reduce the trial and error associated with finding an effective antidepressant by using data from pre-treatment quantification of 5-HT1A receptors and 5-HTT to guide antidepressant treatment selection. ..
  42. Experimental Radiotherapy and Chemotherapy With a Potent New Hypoxic Cytotoxin
    JOHN MARTIN BROWN; Fiscal Year: 2010
    ....
  43. HIGH ENERGY IONS AND GENOMIC INSTABILITY
    Eric Hall; Fiscal Year: 2001
    ....
  44. Deformable image registration and reconstruction for radiotherapy applications
    Martin J Murphy; Fiscal Year: 2010
    ..The third aim of the project is to develop measurement and validation procedures to assess the accuracy and reliability of these novel image registration and reconstruction techniques. ..
  45. Prostate Edema in Permanent Interstitial Brachytherapy
    Zhe Chen; Fiscal Year: 2010
    ..The primary objective of this project is to develop a new method to consider the effects of edema in radiation dosimetry and treatment planning so that the efficacy of this therapy can be optimized for each patient. ..
  46. High-Energy Imaging in Support of Radionuclide Therapy
    AARON BRILL; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  47. EXPERIMENTAL RADIOTHERAPY--BASIS AND MODIFICATION
    John Brown; Fiscal Year: 2002
    ..To test this hypothesis we will employ inhibitors of the topo II catalytic cycle as well as cells induced to express high levels of topo II following TPZ treatment ..
  48. Improving Cancer Outcome--Adaptive Helical Tomotherapy
    Minesh Mehta; Fiscal Year: 2005
    ..Our Program Project will allow Tomotherapy to reach a level of scientific and technological maturity where, in the future, technological intercomparisons through Phase III trials may be undertaken. ..
  49. Imaging of Serotonin Transporters in Depression
    RAMIN PARSEY; Fiscal Year: 2005
    ..These goals will be met by a combination of didactic I course work and supervision. ..
  50. Molecular Targeting of EGFR for the Treatment of Gliomas
    ROLF BARTH; Fiscal Year: 2006
    ..second generation drugs BPA and BSH, produce a significant improvement in survival following BNCT compared to that which we have obtained with BSH and BPA in combination, using the F98EGFR and F98EGFRVIII glioma models?" ..
  51. Dose and image quality in adult and pediatric CT
    Walter Huda; Fiscal Year: 2006
    ..Determine the choice of kVp/mAs and PR/mAs that minimize patient doses with no loss of diagnostic performance. 3. Help the Radiology community to balance the confliciting requirements of image quality and patient doses in clinical CT. ..
  52. Ninth Symposium on Neutron Dosimetry
    Joseph McDonald; Fiscal Year: 2003
    ..S. researchers and those from other countries. The research results to be presented at the symposium will focus on the safe use of neutron radiation in health care and health protection. ..
  53. Feasibility of CT in high risk breast cancer patients
    John Boone; Fiscal Year: 2003
    ..The results of this investigation should provide a clear understanding of the potential of breast CT as a tool to reduce breast cancer mortality in the population of women with dire risk of breast cancer. ..
  54. Experimental Analysis of Advanced Radiotherapy Dosimetry
    JAMES DEMPSEY; Fiscal Year: 2007
    ..Results from this work will provide a paradigm for closing the loop between the clinical treatment planning system and the MLC IMRT delivery system. ..
  55. RESOURCE FACILITY FOR POPULATION KINETICS
    David Foster; Fiscal Year: 2007
    ..RFPK involves four major universities, all of which contribute unique expertise to the individual projects. Its Administrative Core is located at the University of Washington. ..
  56. DIRECT IONIZATION EFFECTS IN DNA
    William Nelson; Fiscal Year: 2002
    ..Final transfer of the results to DNA will be made by carefully selecting and employing the well-defined, DNA-like, systems provided by oligonucleotides. ..
  57. Yeast Gene Ontology by Phenotypic Profiling
    John Brown; Fiscal Year: 2007
    ..abstract_text> ..
  58. Real-Time PDT Dosimetry with Feedback Light Delivery
    Timothy Zhu; Fiscal Year: 2008
    ..abstract_text> ..