radiation dose response relationship

Summary

Summary: The relationship between the dose of administered radiation and the response of the organism or tissue to the radiation.

Top Publications

  1. ncbi Radiation-induced second cancers: the impact of 3D-CRT and IMRT
    Eric J Hall
    Center for Radiological Research, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Int J Radiat Oncol Biol Phys 56:83-8. 2003
  2. pmc Cancer risks attributable to low doses of ionizing radiation: assessing what we really know
    David J Brenner
    Center for Radiological Research, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 100:13761-6. 2003
  3. ncbi Intensity-modulated radiation therapy, protons, and the risk of second cancers
    Eric J Hall
    Center for Radiological Research, Columbia University Medical Center, College of Physicians and Surgeons, New York, NY 10032, USA
    Int J Radiat Oncol Biol Phys 65:1-7. 2006
  4. ncbi Studies of mortality of atomic bomb survivors. Report 13: Solid cancer and noncancer disease mortality: 1950-1997
    Dale L Preston
    Department of Statistics, Radiation Effects Research Foundation, Hiroshima, Japan
    Radiat Res 160:381-407. 2003
  5. ncbi Dynamics of the p53-Mdm2 feedback loop in individual cells
    Galit Lahav
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Genet 36:147-50. 2004
  6. ncbi Is alpha/beta for prostate tumors really low?
    J Fowler
    Department of Human Oncology, University of Wisconsin Madison, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 50:1021-31. 2001
  7. ncbi Risk of thyroid cancer after exposure to 131I in childhood
    Elisabeth Cardis
    International Agency for Research on Cancer, Lyon, France
    J Natl Cancer Inst 97:724-32. 2005
  8. pmc Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses
    Kai Rothkamm
    Fachrichtung Biophysik, Universitat des Saarlandes, 66421 Homburg, Germany
    Proc Natl Acad Sci U S A 100:5057-62. 2003
  9. ncbi Primary thyroid cancer after a first tumour in childhood (the Childhood Cancer Survivor Study): a nested case-control study
    Alice J Sigurdson
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7238, USA
    Lancet 365:2014-23. 2005
  10. ncbi Cell adhesion-mediated radioresistance (CAM-RR). Extracellular matrix-dependent improvement of cell survival in human tumor and normal cells in vitro
    Nils Cordes
    Institute of Radiology, Medical Academy of German Armed Forces, Munich, Germany
    Strahlenther Onkol 179:337-44. 2003

Research Grants

  1. Cancer Risks Attributable To Radiation from Pediatric CT
    David Brenner; Fiscal Year: 2006
  2. High Stability Accelerator for Sub-Cellular Microbeam
    David Brenner; Fiscal Year: 2003
  3. RADIOLOGICAL RESEARCH ACCELERATOR FACILITY (RARAF)
    David Brenner; Fiscal Year: 2002
  4. Targeted Alpha-Particle Emitter Therapy of Metastases
    George Sgouros; Fiscal Year: 2009
  5. Behavioral and Neural Effects of High Magnetic Fields
    THOMAS HOUPT; Fiscal Year: 2009
  6. MODELING AND DOSIMETRY FOR RADIOLABELED ANTIBODY THERAPY
    George Sgouros; Fiscal Year: 2002
  7. The Risk of Cancer in Fanconi Anemia Heterozygotes
    Marianne Berwick; Fiscal Year: 2005
  8. Solar Exposure and Melanoma Survival
    Marianne Berwick; Fiscal Year: 2009
  9. MOLECULAR MECHANISMS OF CONDITIONED TASTE AVERSION
    THOMAS HOUPT; Fiscal Year: 2004
  10. High Throughput Radiation Biodosimetry
    Stephen Dertinger; Fiscal Year: 2007

Detail Information

Publications296 found, 100 shown here

  1. ncbi Radiation-induced second cancers: the impact of 3D-CRT and IMRT
    Eric J Hall
    Center for Radiological Research, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Int J Radiat Oncol Biol Phys 56:83-8. 2003
    ..75% for patients surviving 10 years. The numbers may be larger for longer survival (or for younger patients), but the ratio should remain the same...
  2. pmc Cancer risks attributable to low doses of ionizing radiation: assessing what we really know
    David J Brenner
    Center for Radiological Research, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 100:13761-6. 2003
    ..This linearity assumption is not necessarily the most conservative approach, and it is likely that it will result in an underestimate of some radiation-induced cancer risks and an overestimate of others...
  3. ncbi Intensity-modulated radiation therapy, protons, and the risk of second cancers
    Eric J Hall
    Center for Radiological Research, Columbia University Medical Center, College of Physicians and Surgeons, New York, NY 10032, USA
    Int J Radiat Oncol Biol Phys 65:1-7. 2006
    ..The benefit of protons is only achieved if a scanning beam is used in which the doses are 10 times lower than with IMRT...
  4. ncbi Studies of mortality of atomic bomb survivors. Report 13: Solid cancer and noncancer disease mortality: 1950-1997
    Dale L Preston
    Department of Statistics, Radiation Effects Research Foundation, Hiroshima, Japan
    Radiat Res 160:381-407. 2003
    ..Lifetime risk summaries are used to examine uncertainties of the LSS noncancer disease findings...
  5. ncbi Dynamics of the p53-Mdm2 feedback loop in individual cells
    Galit Lahav
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Genet 36:147-50. 2004
    ..This approach can be used to study other signaling systems and suggests that the p53-Mdm2 feedback loop generates a 'digital' clock that releases well-timed quanta of p53 until damage is repaired or the cell dies...
  6. ncbi Is alpha/beta for prostate tumors really low?
    J Fowler
    Department of Human Oncology, University of Wisconsin Madison, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 50:1021-31. 2001
    ..The implications for possibly treating prostatic cancer using fewer and larger fractions are important. In this paper we review updated clinical data and present somewhat different calculations to estimate alpha/beta...
  7. ncbi Risk of thyroid cancer after exposure to 131I in childhood
    Elisabeth Cardis
    International Agency for Research on Cancer, Lyon, France
    J Natl Cancer Inst 97:724-32. 2005
    ....
  8. pmc Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses
    Kai Rothkamm
    Fachrichtung Biophysik, Universitat des Saarlandes, 66421 Homburg, Germany
    Proc Natl Acad Sci U S A 100:5057-62. 2003
    ....
  9. ncbi Primary thyroid cancer after a first tumour in childhood (the Childhood Cancer Survivor Study): a nested case-control study
    Alice J Sigurdson
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7238, USA
    Lancet 365:2014-23. 2005
    ..We aimed to quantify the long-term risk of thyroid cancer after radiotherapy and chemotherapy...
  10. ncbi Cell adhesion-mediated radioresistance (CAM-RR). Extracellular matrix-dependent improvement of cell survival in human tumor and normal cells in vitro
    Nils Cordes
    Institute of Radiology, Medical Academy of German Armed Forces, Munich, Germany
    Strahlenther Onkol 179:337-44. 2003
    ....
  11. ncbi DNA damage response pathway in radioadaptive response
    Masao S Sasaki
    Radiation Biology Center, Kyoto University, Yoshida Konoecho, Sakyo ku, Kyoto, Japan
    Mutat Res 504:101-18. 2002
    ..A possible molecular mechanism of adaptive response to low-dose ionizing irradiation has been discussed in relation to the repair of DSBs and implicated to the current controversial observations on the expression of adaptive response...
  12. ncbi Feasibility of using intensity-modulated radiotherapy to improve lung sparing in treatment planning for distal esophageal cancer
    Anurag Chandra
    Department of Radiation Oncology, University of Texas, M D Anderson Cancer Center, Houston, USA
    Radiother Oncol 77:247-53. 2005
    ..To evaluate the feasibility whether intensity-modulated radiotherapy (IMRT) can be used to reduce doses to normal lung than three-dimensional conformal radiotherapy (3 DCRT) in treating distal esophageal malignancies...
  13. pmc Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response
    Gary D Kao
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Cell Biol 160:1017-27. 2003
    ..Our combined results suggest that HDAC4 is a critical component of the DNA damage response pathway that acts through 53BP1 and perhaps contributes in maintaining the G2 cell cycle checkpoint...
  14. ncbi Does radiation dose to the salivary glands and oral cavity predict patient-rated xerostomia and sticky saliva in head and neck cancer patients treated with curative radiotherapy?
    Anke Petra Jellema
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Radiother Oncol 77:164-71. 2005
    ..To investigate the association between the mean salivary gland and oral cavity dose, with patient-rated moderate and severe xerostomia and sticky saliva...
  15. ncbi Analysis of radiation-induced chromosomal aberrations using telomeric and centromeric PNA probes
    J J Boei
    MGC, Department of Radiation Genetics and Chemical Mutagenesis, Leiden University Medical Center, The Netherlands
    Int J Radiat Biol 76:163-7. 2000
    ..To generate dose-response curves for X-ray-induced chromosomal aberrations analysed in human blood lymphocytes using telomeric and centromeric peptide nucleic acid (PNA) probes...
  16. pmc Radiation-induced release of transforming growth factor alpha activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell dea
    P Dent
    Department of Radiation Oncology, Massey Cancer Center, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Mol Biol Cell 10:2493-506. 1999
    ..These data demonstrate that disruption of the TGFalpha-EGFR-MAPK signaling module represents a strategy to decrease carcinoma cell growth and survival after irradiation...
  17. ncbi Preliminary results of a randomized radiotherapy dose-escalation study comparing 70 Gy with 78 Gy for prostate cancer
    A Pollack
    Departments of Radiation Oncology, Biostatistics, Urology, and Radiation Physics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 18:3904-11. 2000
    ..To determine the effect of radiotherapy dose on prostate cancer patient outcome and biopsy positivity in a phase III trial...
  18. ncbi Radiation therapy for choroidal melanoma
    P T Finger
    Department of Ophthalmology, New York Eye and Ear Infirmary, New York, USA
    Surv Ophthalmol 42:215-32. 1997
    ..8%) of cases. The purpose of this review is to present the world's experience with radiotherapy for choroidal melanoma, information that will contribute to patient education and informed consent...
  19. ncbi Precise radiochromic film dosimetry using a flat-bed document scanner
    Slobodan Devic
    Medical Physics Department, McGill University Health Centre, Montreal, Quebec H3G IA4, Canada
    Med Phys 32:2245-53. 2005
    ..4 Gy in the case of the EBT (Prototype A), and for doses above 5 Gy in the case of the HS model GafChromic film using a region of interest 2 X 2 mm2 in size...
  20. ncbi Cancer mortality risk among workers at the Mayak nuclear complex
    N S Shilnikova
    Southern Urals Biophysics Institute, Ozyorsk, Russia
    Radiat Res 159:787-98. 2003
    ..As dose estimates for the Mayak workers are improved, it should be possible to obtain more precise estimates of solid cancer and leukemia risks from protracted external radiation exposure in this cohort...
  21. ncbi Intensity-modulated radiation therapy for head and neck carcinoma
    Vincent Gregoire
    Radiation Oncology Department, Universite Catholique de Louvain, St Luc University Hospital, B 1200 Brussels, Belgium
    Oncologist 12:555-64. 2007
    ..Therefore, patient referral to those institutions is recommended...
  22. ncbi A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci
    Enriqueta Riballo
    Genome Damage and Stability Centre, University of Sussex, East Sussex, BN1 9RQ, United Kingdom
    Mol Cell 16:715-24. 2004
    ..The significant radiosensitivity of Artemis-deficient cells demonstrates the importance of this component of DSB repair to survival...
  23. ncbi Effect of recent changes in atomic bomb survivor dosimetry on cancer mortality risk estimates
    Dale L Preston
    Department of Statistics, Radiation Effects Research Foundation, Hiroshima, Japan
    Radiat Res 162:377-89. 2004
    ..Whether or not one makes allowance for this, there is no statistically significant city difference in the estimated cancer risk...
  24. ncbi Meta-analysis of dose-fractionation radiotherapy trials for the palliation of painful bone metastases
    Jackson Sai Yiu Wu
    Division of Radiation Oncology, Hamilton Regional Cancer Centre, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Int J Radiat Oncol Biol Phys 55:594-605. 2003
    ..To compare pain relief among various dose-fractionation schedules of localized radiotherapy (RT) in the treatment of painful bone metastases...
  25. ncbi A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome
    Mark O'Driscoll
    Genome Damage and Stability Centre, University of Sussex, East Sussex, BN1 9RQ, UK
    Nat Genet 33:497-501. 2003
    ..d. below the mean) and dwarfism (5 s.d. below the mean). Our analysis shows that UV-induced ATR activation can occur in non-replicating cells following processing by nucleotide excision repair...
  26. ncbi Tolerance of organs at risk in small-volume, hypofractionated, image-guided radiotherapy for primary and metastatic lung cancers
    Rikiya Onimaru
    Department of Radiology, Hokkaido University School of Medicine, Sapporo, Japan
    Int J Radiat Oncol Biol Phys 56:126-35. 2003
    ..To determine the organ at risk and the maximum tolerated dose (MTD) of radiation that could be delivered to lung cancer using small-volume, image-guided radiotherapy (IGRT) using hypofractionated, coplanar, and noncoplanar multiple fields...
  27. ncbi Repair of DNA damage induced by accelerated heavy ions in mammalian cells proficient and deficient in the non-homologous end-joining pathway
    Ryuichi Okayasu
    International Space Radiation Laboratory, National Institute of Radiological Sciences, Inage Ku, Chiba shi 263 8555, Japan
    Radiat Res 165:59-67. 2006
    ..This delay was further emphasized in NHEJ-defective 180BR cells. Our results indicate that high-LET radiation induces complex DNA damage that is not easily repaired or is not repaired by NHEJ even at low radiation doses such as 2 Gy...
  28. pmc Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells
    Timothy F Burns
    Laboratory of Molecular Oncology and Cell Cycle Regulation, Howard Hughes Medical Institute, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 23:5556-71. 2003
    ..Finally, these studies suggest that disruption of Snk/Plk2 may be of therapeutic value in sensitizing paclitaxel-resistant tumors...
  29. ncbi Second malignancy after Hodgkin disease treated with radiation therapy with or without chemotherapy: long-term risks and risk factors
    Andrea K Ng
    Department of Radiation Oncology and the Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Blood 100:1989-96. 2002
    ..Our analysis suggests that the risk may be reduced with smaller radiation fields, as are used in current trials of abbreviated chemotherapy and limited-field radiation therapy...
  30. ncbi Atm-deficient mice: a paradigm of ataxia telangiectasia
    C Barlow
    Laboratory of Genetic Disease Research, National Center for Human Genome Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell 86:159-71. 1996
    ..Atm-disrupted mice recapitulate the ataxia telangiectasia phenotype in humans, providing a mammalian model in which to study the pathophysiology of this pleiotropic disorder...
  31. ncbi Ionizing radiation-induced apoptosis of proliferating stem cells in the dentate gyrus of the adult rat hippocampus
    W Peissner
    Max Planck Institute for Neurological Research, Department for Experimental Neurology, Gleueler Strasse 50, 50931, Cologne, Germany
    Brain Res Mol Brain Res 71:61-8. 1999
    ....
  32. pmc Low-dose radiation: thresholds, bystander effects, and adaptive responses
    William M Bonner
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 37, Room 5050A, MSC 4255, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:4973-5. 2003
  33. ncbi Factors predicting radiation pneumonitis in lung cancer patients: a retrospective study
    Tiziana Rancati
    Physics Department, University of Milano, Via Celoria 16, 20133, Milan, Italy
    Radiother Oncol 67:275-83. 2003
    ..To evaluate clinical and lung dose-volume histogram based factors as predictors of radiation pneumonitis (RP) in lung cancer patients (PTs) treated with thoracic irradiation...
  34. pmc NF-kappa B-mediated adaptive resistance to ionizing radiation
    Kazi Mokim Ahmed
    Division of Molecular Radiobiology and Graduate Program of Radiation and Cancer Biology, Purdue University School of Health Sciences, West Lafayette, IN 47907, USA
    Free Radic Biol Med 44:1-13. 2008
    ..Further elucidation of the key elements in this prosurvival network may generate novel targets for resensitizing the radioresistant tumor cells...
  35. ncbi Osteoradionecrosis of the mandible: minimized risk profile following intensity-modulated radiation therapy (IMRT)
    Gabriela Studer
    Department of Radiation Oncology, University Hospital, Zurich, Switzerland
    Strahlenther Onkol 182:283-8. 2006
    ..The aim of this descriptive study was to assess absolute and relative bone volumes exposed to high IMRT doses, related to observed bone tolerance...
  36. ncbi Radiobiological mechanisms in inflammatory diseases of low-dose radiation therapy
    F Rodel
    Department of Radiotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Int J Radiat Biol 83:357-66. 2007
    ..Experimental studies to confirm the effectiveness, the empirical dose and fractionation schemes, and the underlying radiobiological mechanisms are still fragmentary...
  37. ncbi A comprehensive study of p53 transcriptional activity in thymus and spleen of gamma irradiated mouse: high sensitivity of genes involved in the two main apoptotic pathways
    Sandra Alvarez
    Commissariat a l Energie Atomique CEA, Centre National de la Recherche Scientifique CNRS, Laboratoire de Cancérogenèse Moléculaire, 92265 Fontenay aux Roses Cedex, France
    Int J Radiat Biol 82:761-70. 2006
    ..Most in vivo published data referred to high (lethal) irradiation doses. The present study was performed to analyse the p53-dependent response to more relevant low irradiation doses...
  38. ncbi Action spectrum for melatonin regulation in humans: evidence for a novel circadian photoreceptor
    G C Brainard
    Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Neurosci 21:6405-12. 2001
    ..The data also suggest that this new photopigment is retinaldehyde based. These findings suggest that there is a novel opsin photopigment in the human eye that mediates circadian photoreception...
  39. ncbi Partial volume tolerance of the spinal cord and complications of single-dose radiosurgery
    Samuel Ryu
    Department of Radiation Oncology, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Cancer 109:628-36. 2007
    ..The tolerance of partial volume of the spinal cord may determine the extent of clinical application. The study analyzed the partial volume tolerance of the human spinal cord to single fraction radiosurgery...
  40. pmc Azathioprine and UVA light generate mutagenic oxidative DNA damage
    Peter O'Donovan
    Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK
    Science 309:1871-4. 2005
    ..These findings may partly explain the prevalence of skin cancer in long-term survivors of organ transplantation...
  41. ncbi Inhibition of homologous recombination repair in irradiated tumor cells pretreated with Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin
    Miho Noguchi
    Graduate School of Science and Technology, Chiba University, Inage Ku, Chiba 263 8522, Japan
    Biochem Biophys Res Commun 351:658-63. 2006
    ..Our data demonstrate for the first time that 17-AAG inhibits the HR repair process and could provide a new therapeutic strategy to selectively result in higher tumor cell killing...
  42. ncbi Enhanced cell killing induced by the combination of radiation and the heat shock protein 90 inhibitor 17-allylamino-17- demethoxygeldanamycin: a multitarget approach to radiosensitization
    Jeffery S Russell
    Molecular Radiation Therapeutics Branch, Radiation Oncology Science Program, National Cancer Institute, Bethesda, Maryland 20892, USA
    Clin Cancer Res 9:3749-55. 2003
    ..Therefore, in an attempt to increase the probability and/or degree of radiosensitization, we have begun to investigate a multitarget approach using the heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17AAG)...
  43. ncbi Bystander effect and adaptive response in C3H 10T(1/2) cells
    S A Mitchell
    Center for Radiological Research, Columbia University, New York, NY 10032, USA
    Int J Radiat Biol 80:465-72. 2004
    ..To address the relationship between the bystander effect and the adaptive response that can compete to impact on the dose-response curve at low doses...
  44. ncbi Evaluation of five radiation schedules and prognostic factors for metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg, Martinistr 52, D 20246 Hamburg, Germany
    J Clin Oncol 23:3366-75. 2005
    ..To study five radiotherapy (RT) schedules and potential prognostic factors for functional outcome in metastatic spinal cord compression (MSCC)...
  45. ncbi Loss of biological effect in prolonged fraction delivery
    Jack F Fowler
    Department of Human Oncology, Medical School, University of Wisconsin, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 59:242-9. 2004
    ..In this article, we model repair rates for a range of doses per fraction and draw conclusions...
  46. ncbi Ex vivo culture rescues hematopoietic stem cells with long-term repopulating capacity following harvest from lethally irradiated mice
    John P Chute
    Large Scale Biology Corporation, Vacaville, Calif, USA
    Exp Hematol 32:308-17. 2004
    ..High-dose ionizing radiation can cause lethal myeloablation in exposed individuals. We examined whether ex vivo culture could rescue hematopoietic stem cells with repopulating capacity following harvest from lethally irradiated animals...
  47. ncbi Risk of radiation-induced subcutaneous fibrosis in relation to single nucleotide polymorphisms in TGFB1, SOD2, XRCC1, XRCC3, APEX and ATM--a study based on DNA from formalin fixed paraffin embedded tissue samples
    C N Andreassen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    Int J Radiat Biol 82:577-86. 2006
    ..The present study was conducted to seek a confirmation of these findings...
  48. ncbi Relative biological effectiveness of 280 keV neutrons for apoptosis in human lymphocytes
    L A Ryan
    McMaster University, Medical Physics and Applied Radiation Sciences Unit, 1280 Main St West, Hamilton, Ontario, Canada L8S 4K1
    Health Phys 91:68-75. 2006
    ..As apoptosis is a major process that influences the consequences of radiation exposure, our results indicate that biological effect and the corresponding weighting factors for 280 keV neutrons may be lower in some cell types and tissues...
  49. ncbi Rectal sequelae after conformal radiotherapy of prostate cancer: dose-volume histograms as predictive factors
    S Wachter
    Department of Radiotherapy and Radiobiology, University Hospital of Vienna, Vienna, Austria
    Radiother Oncol 59:65-70. 2001
    ..The rV90 seems to be the most useful and easily obtained parameter when comparing treatment plans to evaluate the risk of rectal morbidity...
  50. ncbi Low dose hypersensitivity in the T98G human glioblastoma cell line
    S Short
    Gray Laboratory Cancer Research Trust, Mount Vernon Hospital, Northwood, UK
    Int J Radiat Biol 75:847-55. 1999
    ..To examine the low dose-response of a human radioresistant glioblastoma cell line (T98G) using two different methods to measure surviving fraction and to define the influence of cell cycle phase on this response...
  51. ncbi Organ-specific gene expressions in C57BL/6 mice after exposure to low-dose radiation
    Woo Jung Lee
    Laboratory of Radiation Effect, Korea Institute of Radiological and Medical Sciences, Seoul 139 06, Korea
    Radiat Res 165:562-9. 2006
    ..These data suggested possible tissue-specific markers of low-dose radiation exposure and suggested potential novel genetic modifiers of radiation response...
  52. ncbi Tumor radiosensitivity (SF2) is a prognostic factor for local control in head and neck cancers
    T Björk-Eriksson
    Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden
    Int J Radiat Oncol Biol Phys 46:13-9. 2000
    ..To evaluate prospectively the prognostic value of SF2 for local control and survival in patients undergoing radiation therapy for head and neck cancers...
  53. ncbi Late rectal toxicity after conformal radiotherapy of prostate cancer (I): multivariate analysis and dose-response
    M W Skwarchuk
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA
    Int J Radiat Oncol Biol Phys 47:103-13. 2000
    ....
  54. ncbi The linear-quadratic model is inappropriate to model high dose per fraction effects in radiosurgery
    John P Kirkpatrick
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Semin Radiat Oncol 18:240-3. 2008
    ....
  55. ncbi Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus
    Thomas E Bartlett
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK
    Neuropharmacology 52:60-70. 2007
    ..4 microM. The lack of effect of 0.1 microM NVP on LTD contrasts with its marked effect on LTP and raises the possibility that different NVP-sensitive NR2 subunit-containing NMDA receptors are required for LTP and LTD in this preparation...
  56. ncbi Prediction of normal tissue radiosensitivity from polymorphisms in candidate genes
    Christian Nicolaj Andreassen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Noerrebrogade 44, Aarhus C DK 8000, Denmark
    Radiother Oncol 69:127-35. 2003
    ..This study investigates whether seven selected SNPs in five candidate genes influence risk of subcutaneous fibrosis and telangiectasia after radiotherapy...
  57. ncbi Enhanced tumor cell radiosensitivity and abrogation of G2 and S phase arrest by the Hsp90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin
    Elizabeth E A Bull
    Molecular Radiation Therapeutics Branch, Radiation Oncology Branch, Developmental Therapeutics Program, National Cancer Institute, Bethesda, Maryland, USA
    Clin Cancer Res 10:8077-84. 2004
    ..Therefore, we have investigated the effects of the orally bioavailable Hsp90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG) on the radiosensitivity of human tumor cells in vitro and grown as tumor xenografts...
  58. pmc Transcriptional response of lymphoblastoid cells to ionizing radiation
    Kuang Yu Jen
    Departments of Pediatrics and Genetics, University of Pennsylvania, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Genome Res 13:2092-100. 2003
    ..These findings will allow a better understanding of complex processes such as radiation-induced carcinogenesis and the development of biomarkers for radiation exposure...
  59. ncbi The calculated risk of fatal secondary malignancies from intensity-modulated radiation therapy
    Stephen F Kry
    Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 62:1195-203. 2005
    ..Step-and-shoot intensity-modulated radiation therapy (IMRT), an increasingly popular treatment modality, yields higher out-of-field doses than do conventional treatments, because of an increase in required monitor units (beam-on time)...
  60. ncbi Ultraviolet B radiation-induced cell death: critical role of ultraviolet dose in inflammation and lupus autoantigen redistribution
    Roberto Caricchio
    Department of Medicine, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 171:5778-86. 2003
    ..The key importance of the UV dose on the fate of apoptotic keratinocytes and on their potential immunogenicity should help clarify the role of UVB in inducing systemic lupus erythematosus autoimmunity...
  61. ncbi P53 plays a protective role against UV- and cisplatin-induced apoptosis in transcription-coupled repair proficient fibroblasts
    B C McKay
    Centre for Cancer Therapeutics, Ottawa Regional Cancer Centre, 503 Smyth Road, Ottawa, Ontario K1H 1C4, Canada
    Oncogene 20:6805-8. 2001
    ..Therefore, we propose that p53 protects against UV- and cisplatin-induced apoptosis in a TCR-dependent manner and that p53 does not contribute strongly to the induction of apoptosis in TCR-deficient fibroblasts...
  62. ncbi The bystander effect
    Eric J Hall
    Columbia University, Center for Radiological Research, 630 West 168th Street, New York, NY 10032, USA
    Health Phys 85:31-5. 2003
    ..Bystander studies imply that the target for the biological effects of radiation is larger than the cell and this could make a simple linear extrapolation of radiation risks from high to low doses of questionable validity...
  63. ncbi Spontaneous radiation-induced rib fractures in breast cancer patients treated with postmastectomy irradiation. A clinical radiobiological analysis of the influence of fraction size and dose-response relationships on late bone damage
    M Overgaard
    Department of Oncology and Radiotherapy, Radiumstationen, Aarhus, Denmark
    Acta Oncol 27:117-22. 1988
    ..Using the linear quadratic model, alpha/beta ratios for late bone damage were estimated to be within the range of 1.8-2.8 Gy, i.e. similar to those reported for other late responding normal tissues...
  64. ncbi Concomitant cisplatin significantly improves locoregional control in advanced head and neck cancers treated with hyperfractionated radiotherapy
    Pia Huguenin
    Department of Radiation Oncology, University Hospital Zurich, Zurich, Switzerland
    J Clin Oncol 22:4665-73. 2004
    ....
  65. ncbi The alkaline Comet assay as biomarker in assessment of DNA damage in medical personnel occupationally exposed to ionizing radiation
    Vera Garaj-Vrhovac
    Laboratory of Mutagenesis, Institute for Medical Research and Occupational Health, HR 10 000 Zagreb, Croatia
    Mutagenesis 18:265-71. 2003
    ..By detection of momentary DNA damage and/or repair activity, it reflects the concurrent exposure and the actual levels of DNA damage present in peripheral blood leukocytes of the radiological workers at the moment of blood sampling...
  66. ncbi Geldanamycin, an inhibitor of Hsp90, sensitizes human tumour cells to radiation
    H Machida
    Department of Radiological Sciences, Ibaraki Prefectural University of Health Sciences, Ami Machi, Ibaraki 300 0394, Japan
    Int J Radiat Biol 79:973-80. 2003
    ..The effects of the heat shock protein 90 (Hsp90) inhibitor geldanamycin (GA) were examined on the radiosensitivity and signal transduction pathways in human tumour cell lines...
  67. ncbi 50-Hz extremely low frequency electromagnetic fields enhance cell proliferation and DNA damage: possible involvement of a redox mechanism
    Federica I Wolf
    Institute of General Pathology and Giovanni XXIII Cancer Research Center, L go F Vito, 1 00168 Rome, Italy
    Biochim Biophys Acta 1743:120-9. 2005
    ..This information may be of value for appraising the pathophysiologic consequences of an exposure to ELF-EMF...
  68. ncbi Evidence for beneficial low level radiation effects and radiation hormesis
    L E Feinendegen
    Heinrich Heine University Dusseldorf, Germany
    Br J Radiol 78:3-7. 2005
    ..The LNT hypothesis should be abandoned and be replaced by a hypothesis that is scientifically justified and causes less unreasonable fear and unnecessary expenditure...
  69. ncbi Cancer risk estimates from the combined Japanese A-bomb and Hodgkin cohorts for doses relevant to radiotherapy
    Uwe Schneider
    Division of Medical Physics, Department of Radiation Oncology and Nuclear Medicine, The Triemli Hospital Zürich, 8063 Zurich, Switzerland
    Radiat Environ Biophys 47:253-63. 2008
    ..The work presented here also provides the first direct evidence that the bending over of the solid cancer excess risk dose response curve for the A-bomb survivors, generally observed above 2 Gy, is due to cell killing effects...
  70. ncbi How low is the alpha/beta ratio for prostate cancer?
    Jian Z Wang
    Department of Radiation Oncology, University of Maryland, Baltimore, MD 21201, USA
    Int J Radiat Oncol Biol Phys 55:194-203. 2003
    ..In this paper, we present a comprehensive analysis of the updated clinical data to derive a self-consistent set of parameters for the linear-quadratic (LQ) model...
  71. ncbi Can we reduce the incidence of second primary malignancies occurring after radiotherapy? A critical review
    Maurice Tubiana
    Institute Gustave Roussy, Villejuif, France
    Radiother Oncol 91:4-15; discussion 1-3. 2009
    ..In parallel, radiation therapy philosophy must evolve, and the aim of treatment should be to deliver the minimal effective radiation therapy rather than the maximal tolerable dose...
  72. ncbi H2AX phosphorylation after UV irradiation is triggered by DNA repair intermediates and is mediated by the ATR kinase
    Sheela Hanasoge
    Department of Radiation Oncology, Division of Radiation and Cancer Biology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109 2200, USA
    Carcinogenesis 28:2298-304. 2007
    ..We suggest a model for UV light-induced phosphorylation of H2AX where in addition to replication blockage, DNA repair intermediates trigger H2AX phosphorylation via the ATR kinase...
  73. ncbi Inhibition of Chk1-dependent G2 DNA damage checkpoint radiosensitizes p53 mutant human cells
    K Koniaras
    Trescowthick Research Laboratories, Peter MacCallum Cancer Institute, A'Beckett St, Melbourne, VIC 8006 Australia
    Oncogene 20:7453-63. 2001
    ..Importantly, inhibition of Chk1 in p53 deficient cells greatly sensitizes them to radiation, validating the hypothesis of targeting Chk1 in rational drug design and development for anti-cancer therapies...
  74. ncbi Low-dose of ionizing radiation enhances cell proliferation via transient ERK1/2 and p38 activation in normal human lung fibroblasts
    Cha Soon Kim
    Radiation Health Research Institute, Korea Hydro and Nuclear Power Co, Ltd, Seoul, Republic of Korea
    J Radiat Res 48:407-15. 2007
    ..05 Gy of ionizing radiation. These results suggest that 0.05 Gy of ionizing radiation enhances cell proliferation through the activation of ERK1/2 and p38 in normal human lung fibroblasts...
  75. ncbi Radiation-induced cardiovascular diseases: is the epidemiologic evidence compatible with the radiobiologic data?
    Susanne Schultz-Hector
    Helmholtz Gemeinschaft, Berlin, Germany
    Int J Radiat Oncol Biol Phys 67:10-8. 2007
    ....
  76. ncbi Intensity modulated radiation therapy (IMRT) decreases acute skin toxicity for women receiving radiation for breast cancer
    Gary M Freedman
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Am J Clin Oncol 29:66-70. 2006
    ..Our hypothesis is that measures to decrease dose inhomogeneity within the breast and skin with IMRT will improve acute skin toxicity...
  77. ncbi TP53 and TP53-related genes associated with protection from apoptosis in the radioadaptive response
    Ryuji Okazaki
    Department of Radiation Biology and Health, School of Medicine, University of Occupational and Environmental Health, Japan, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Radiat Res 167:51-7. 2007
    ..We conclude that TP53 plays a critical role in the radioadaptive response and that TP53 and TP53-related genes might protect cells from apoptosis through activation of the intracellular repair system...
  78. ncbi Activation of multiple DNA repair pathways by sub-nuclear damage induction methods
    Christoffel Dinant
    Department of Pathology, Josephine Nefkens Institute, ErasmusMC, Rotterdam, The Netherlands
    J Cell Sci 120:2731-40. 2007
    ..Whereas, application of low-dose 266 nm laser irradiation induced only UV-specific DNA photo-lesions allowing the study of the UV-C-induced DNA damage response in a user-defined area in cultured cells...
  79. ncbi The effect of fraction time in intensity modulated radiotherapy: theoretical and experimental evaluation of an optimisation problem
    Xiangkui Mu
    Department of Radiation Sciences, Oncology, Umea University, SE 901 87 Umea, Sweden
    Radiother Oncol 68:181-7. 2003
    ..In this paper the effect of changes in fraction delivery time was studied by in vitro irradiation of mammalian cells...
  80. ncbi Tumors of the nervous system and pituitary gland associated with atomic bomb radiation exposure
    Dale L Preston
    Department of Statistics, Radiation Effects Research Foundation, Hiroshima, Japan
    J Natl Cancer Inst 94:1555-63. 2002
    ..The risk of developing nervous system tumors following exposure to ionizing radiation is not well quantified. We characterized the incidence of nervous system tumors among atomic bomb survivors as a function of radiation dose...
  81. pmc An Arabidopsis photolyase mutant is hypersensitive to ultraviolet-B radiation
    L G Landry
    The Boyce Thompson Institute for Plant Research, Cornell University, Ithaca, NY 14853 1801, USA
    Proc Natl Acad Sci U S A 94:328-32. 1997
    ..This mutant provides evidence that CPD photolyase is required for plant survival in the presence of UV-B light...
  82. ncbi Cyclobutane pyrimidine dimers are responsible for the vast majority of mutations induced by UVB irradiation in mammalian cells
    Y H You
    Department of Biology, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA
    J Biol Chem 276:44688-94. 2001
    ..We conclude that CPDs are responsible for at least 80% of the UVB-induced mutations in this mammalian cell model...
  83. pmc The non-cancer mortality experience of male workers at British Nuclear Fuels plc, 1946-2005
    Dave McGeoghegan
    Westlakes Scientific Consulting, Moor Row, Cumbria CA24 3LN, UK
    Int J Epidemiol 37:506-18. 2008
    ..The aim of this study was to establish whether such a trend could be found in a large cohort of employees in the UK nuclear industry...
  84. pmc An action spectrum for melatonin suppression: evidence for a novel non-rod, non-cone photoreceptor system in humans
    K Thapan
    Centre for Chronobiology, School of Biomedical and Life Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK
    J Physiol 535:261-7. 2001
    ..74). 5. Our data strongly support a primary role for a novel short-wavelength photopigment in light-induced melatonin suppression and provide the first direct evidence of a non-rod, non-cone photoreceptive system in humans...
  85. pmc Stereotactic, single-dose irradiation of stage I non-small cell lung cancer and lung metastases
    Peter Fritz
    St Marien Krankenhaus, Medical Education Hospital of the University of Marburg, Department of Radiotherapy, D 57072 Siegen, Germany
    Radiat Oncol 1:30. 2006
    ..We prospectively reviewed response rates, local control, and side effects after non-fractionated stereotactic high single-dose body radiation therapy for lung tumors...
  86. ncbi Simple spike and complex spike activity of floccular Purkinje cells during the optokinetic reflex in mice lacking cerebellar long-term depression
    H H L M Goossens
    Department of Neuroscience, Erasmus MC, Dr Molewaterplein 50, 3000 DR Rotterdam, The Netherlands
    Eur J Neurosci 19:687-97. 2004
    ..The data thus strengthen the evidence that cerebellar LTD is implicated in rapid VOR learning but not in the development of normal default response patterns...
  87. ncbi Evidence behind use of intensity-modulated radiotherapy: a systematic review of comparative clinical studies
    Liv Veldeman
    Department of Radiotherapy, Ghent University Hospital, Ghent, Belgium
    Lancet Oncol 9:367-75. 2008
    ..This review shows evidence of reduced toxicity for various tumour sites by use of IMRT. The findings regarding local control and overall survival are generally inconclusive...
  88. ncbi A review of the bystander effect and its implications for low-dose exposure
    K M Prise
    Gray Cancer Institute, PO Box 100, Mount Vernon Hospital, Northwood, Middlesex HA6 2JR, UK
    Radiat Prot Dosimetry 104:347-55. 2003
    ..The involvement of competing processes at low doses may have important consequences for understanding the effects of low-dose exposure...
  89. ncbi Analysis by alkaline comet assay of cancer patients with severe reactions to radiotherapy: defective rejoining of radioinduced DNA strand breaks in lymphocytes of breast cancer patients
    C Alapetite
    UMR 218 CNRS IC, Institut Curie Recherche, Paris, France
    Int J Cancer 83:83-90. 1999
    ..Thus, the alkaline comet assay appears to be useful for documenting the DNA repair phenotype in cancer patients...
  90. ncbi Characterization and real-time optical measurements of the ionizing radiation dose response for a new radiochromic medium
    Alexandra Rink
    Princess Margaret Hospital Ontario Cancer Institute, Department of Medical Biophysics aind Radiation Oncology, University of Toronto, Toronto, Ontario Canada
    Med Phys 32:2510-6. 2005
    ..8% over a sixfold variation in dose rate. Overall, GafChromic EBT has increased sensitivity and decreased postexposure darkening, and this bodes well for its potential role as a radiation dosimeter, including real-time applications...
  91. ncbi Time dependence of the activity concentration ratio of red marrow to blood and implications for red marrow dosimetry
    Cecilia Hindorf
    Department of Radiation Physics, Lund University, Lund, Sweden
    Cancer 94:1235-9. 2002
    ..The activity concentration ratio of red marrow to blood is then assumed to be constant. The aim of the current study was to determine whether this ratio varies with time after injection...
  92. ncbi Absorption spectra variations of EBT radiochromic film from radiation exposure
    M J Butson
    Department of Physics and Materials Science, City University of Hong Kong, Kowloon Tong, Hong Kong
    Phys Med Biol 50:N135-40. 2005
    ..The film provides adequate relative absorbed dose measurement for clinical radiotherapy x-ray assessment in the 1-2 Gy dose range which with further investigation may be useful for fractionated radiotherapy dose assessment...
  93. ncbi A systematic review of epidemiological associations between low and moderate doses of ionizing radiation and late cardiovascular effects, and their possible mechanisms
    M P Little
    Department of Epidemiology and Public Health, Imperial College Faculty of Medicine, London W2 1PG, United Kingdom
    Radiat Res 169:99-109. 2008
    ..Further epidemiological and biological evidence will allow a firmer conclusion to be drawn...
  94. ncbi Radiation dose, chemotherapy and risk of lung cancer after breast cancer treatment
    Carole Rubino
    Unit of Cancer Epidemiology, National Institute of Health and Medical Research U521 INSERM, Institut Gustave Roussy, Villejuif, France
    Breast Cancer Res Treat 75:15-24. 2002
    ..10) per gray delivered to the site of lung cancer was evidenced. Our results agree with previous studies in favor of an increased risk of lung cancer after radiation therapy for breast cancer...
  95. ncbi Radioadaptive response: efficient repair of radiation-induced DNA damage in adapted cells
    T Ikushima
    Biology Division, Kyoto University of Education, Japan
    Mutat Res 358:193-8. 1996
    ....
  96. ncbi Low-dose hypersensitivity: current status and possible mechanisms
    M C Joiner
    Gray Laboratory Cancer Research Trust, Mount Vernon Hospital, Northwood, Middlesex, UK
    Int J Radiat Oncol Biol Phys 49:379-89. 2001
    ..In this paper, we propose possible mechanisms to explain this phenomenon based on our data accumulated over the last decade and a review of the literature...
  97. ncbi "Edge Effect" of (32)p radioactive stents is caused by the combination of chronic stent injury and radioactive dose falloff
    W J van der Giessen
    Department of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands
    Circulation 104:2236-41. 2001
    ....
  98. ncbi Mononuclear cell adhesion and cell adhesion molecule liberation after X-irradiation of activated endothelial cells in vitro
    G Hildebrandt
    Department of Radiotherapy and Radiooncology, University of Leipzig, Liebigstrasse 20a, 04103 Leipzig, Germany
    Int J Radiat Biol 78:315-25. 2002
    ..The hypothesis that it may act by modulation of cell adhesion molecule expression in activated endothelial cells and the subsequent adhesion of mononuclear cells onto the activated endothelial cells was tested...
  99. ncbi Relative roles of ICAM-1 and VCAM-1 in the pathogenesis of experimental radiation-induced intestinal inflammation
    Meritxell Molla
    Department of Gastroenterology, Hospital Clinic, Institut de Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Int J Radiat Oncol Biol Phys 57:264-73. 2003
    ..Our objective was to characterize the requirement for intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) in intestinal inflammatory response after abdominal irradiation...
  100. ncbi Stillbirths among offspring of male radiation workers at Sellafield nuclear reprocessing plant
    L Parker
    Department of Child Health, University of Newcastle upon Tyne, UK
    Lancet 354:1407-14. 1999
    ....
  101. pmc The ratio of initial/residual DNA damage predicts intrinsic radiosensitivity in seven cervix carcinoma cell lines
    B Marples
    Cancer Research Campaign Department of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK
    Br J Cancer 77:1108-14. 1998
    ..99), representing the fraction of DNA damage remaining. These results indicate that the neutral comet assay can be used to predict radiosensitivity of cervical tumour cell lines by assessing the ratio of initial and residual DNA dsbs...

Research Grants65

  1. Cancer Risks Attributable To Radiation from Pediatric CT
    David Brenner; Fiscal Year: 2006
    ..The target audiences will be radiologists, pediatricians, family physicians, and the CT industry. We will use telephone interviews supplemented with survey questions, to aid in web content decisions. ..
  2. High Stability Accelerator for Sub-Cellular Microbeam
    David Brenner; Fiscal Year: 2003
    ..We have considerably more demand for microbeam time than we can cope with, primarily because of limited physicist manpower. ..
  3. RADIOLOGICAL RESEARCH ACCELERATOR FACILITY (RARAF)
    David Brenner; Fiscal Year: 2002
    ..abstract_text> ..
  4. Targeted Alpha-Particle Emitter Therapy of Metastases
    George Sgouros; Fiscal Year: 2009
    ..The work described in this application is intended to develop and evaluate such an approach. ..
  5. Behavioral and Neural Effects of High Magnetic Fields
    THOMAS HOUPT; Fiscal Year: 2009
    ..Secondly, vestibular dysfunction is a common complaint and cause of injury (e.g. falling in the elderly), and this proposal contains novel approaches to investigating the inner ear and vestibular system ..
  6. MODELING AND DOSIMETRY FOR RADIOLABELED ANTIBODY THERAPY
    George Sgouros; Fiscal Year: 2002
    ....
  7. The Risk of Cancer in Fanconi Anemia Heterozygotes
    Marianne Berwick; Fiscal Year: 2005
    ..Analyses will be undertaken to evaluate the role of Fanconi anemia heterozygosity for cancer. If carriers are found to be at increased risk, this information can be used to target individuals for cancer prevention strategies. ..
  8. Solar Exposure and Melanoma Survival
    Marianne Berwick; Fiscal Year: 2009
    ..2. Determine whether functional polymorphic variants in the vitamin D receptor affect survival from melanoma. 3. Investigate the interaction of lifetime solar exposure and polymorphisms in VDR and its effect on survival. ..
  9. MOLECULAR MECHANISMS OF CONDITIONED TASTE AVERSION
    THOMAS HOUPT; Fiscal Year: 2004
    ..These experiments will contribute to an understanding of the neural pathways and molecular mechanisms underlying changes in food preferences that occur in eating disorders such as obesity and anorexia nervosa. ..
  10. High Throughput Radiation Biodosimetry
    Stephen Dertinger; Fiscal Year: 2007
    ..We propose to develop such a radiation biodosimetry assay based on the extremely high analysis rates that are possible with flow cytometry instrumentation. [unreadable] [unreadable] [unreadable]..
  11. Versatile Mutation Assay Platform
    Stephen Dertinger; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  12. MECHANISM OF PAIN IN PATIENTS WITH FIBROMYALGIA SYNDROME
    Roland Staud; Fiscal Year: 2008
    ..In addition, our findings may contribute to the understanding of pain mechanisms related to other chronic pain disorders. ..
  13. In vivo mutation assay based on pig-a locus
    Stephen Dertinger; Fiscal Year: 2004
    ....
  14. MECHANISMS OF ARSENIC CARCINOGENESIS
    TOM HEI; Fiscal Year: 2005
    ..abstract_text> ..
  15. Rapid Screen for Genotoxicants, Chemoprotectors, and Radioprotectors
    Stephen Dertinger; Fiscal Year: 2008
    ..In addition, this assay can be used to investigate agents designed to ameliorate the effects of radiation exposure, e.g. biological response modifiers. [unreadable] [unreadable] [unreadable] [unreadable]..
  16. MECHANISMS OF FIBER CARCINOGENESIS
    TOM HEI; Fiscal Year: 2001
    ..Cytogenetic and molecular alterations at the gene level will be analyzed from tumors and intermediate transformation stages to provide a mechanistic basis for tumor induction by mineral fibers. ..
  17. Using light to increase visual and perceptual cues and decrease falls risk
    MARIANA FIGUEIRO; Fiscal Year: 2010
    ....
  18. Non-Invasive Localization of Vulnerable Plaques
    Cynthia McCollough; Fiscal Year: 2009
    ....
  19. Peripheral and Central Mechanism of Pain in Patients with Fibromyalgia
    ROLAND M STAUD; Fiscal Year: 2010
    ..Either way, we will provide evidence that will characterize the role of local anesthesia, placebo analgesia, or both. Thus patients with FM and other similar pain syndromes may strongly benefit from the results of our study. ..
  20. THE MUTAGENICITY OF MINERAL FIBERS
    TOM HEI; Fiscal Year: 2006
    ..By using specific DNA probes of other genes that have been regionally mapped to various sites on chromosome 11, the molecular spectrum of mutations induced by either asbestos or glass fiber control will be compared. ..
  21. Measuring Cytogenetic Damage in Human Blood
    Stephen Dertinger; Fiscal Year: 2003
    ..abstract_text> ..
  22. Automation of the vitro Micronucleus Assay
    Stephen Dertinger; Fiscal Year: 2004
    ..abstract_text> ..
  23. Optical stimulation of the auditory nerve
    AGNELLA IZZO; Fiscal Year: 2006
    ..Aim (2) will utilize the variable-wavelength, variable-repetition rate Free Electron Laser to demonstrate optical stimulation of auditory neurons at high repetition rates. [unreadable] [unreadable] [unreadable]..
  24. Indexical and Semantic Cues
    ROBERT HIENZ; Fiscal Year: 2006
    ..The proposed research will extend our knowledge of the acoustic communication abilities of baboons and their relationships to the evolution of human communication. ..
  25. MECHANISMS OF LOCAL SYNAPTIC TRANSMISSION IN DORSAL HORN
    Stephen Schneider; Fiscal Year: 2007
    ..The studies will provide essential information about dynamic modulation of synaptic function underlying spinal integration of innocuous and noxious sensory information. ..
  26. FUNCTIONAL AND HEALTH CHANGES OF THE ELDERLY
    Kenneth Manton; Fiscal Year: 2006
    ..The disability and health sections of this survey will form a consistent time series comprised of the 1982, 1984, 1989, 1994, 1999 and now 2004 NLTCS. The 2004 NLTCS data will be released rapidly to other researchers. ..
  27. Non-invasive beta-cell imaging using a Ga-68-labeled glucagone-like peptide-1 ana
    Martin Gotthardt; Fiscal Year: 2008
    ..Apart from proof-of-principle studies in healthy volunteers and diabetes type I and II patients, a dosimetric method will be established to simply and reliably quantify beta-cell mass by PET imaging. [unreadable] [unreadable]..
  28. Quality of Life of Testicular Cancer Survivors
    Yawei Zhang; Fiscal Year: 2008
    ..The increasing incidence of TC in young men, and the high survival rate, makes understanding the morbidity associated with TC survival a public health priority. [unreadable] [unreadable] [unreadable]..
  29. ENHANCED APOPTOSIS BY TARGETING PROTEIN REDOX STATUS
    Mohan Natarajan; Fiscal Year: 2009
    ..abstract_text> ..
  30. MECHANISMS OF CANNABINOID'S ANTIEMETIC ACTIONS
    NISSAR DARMANI; Fiscal Year: 2007
    ..The results will have important implications for the therapeutic utility of these "agonist antiemetics". [unreadable] [unreadable]..
  31. BYSTANDER EFFECTS AND X RAY INDUCED GENOMIC INSTABILITY
    William Morgan; Fiscal Year: 2004
    ..Identifying the BSEF would enhance our understanding of how radiation exerts its deleterious effects and could directly impact risk estimation for radiation exposure. ..
  32. IN VIVO RADIATION DOSIMETRY WITH AN IMPLANTABLE DEVICE
    Charles Scarantino; Fiscal Year: 2004
    ..This telemetric implantable technology is designed to serve as a platform for additional novel oncologic applications (i.e., radiolabeled drug uptake, pH, etc.). ..
  33. THE ROLE OF A NOVEL GENE, NNAL, IN NEURONAL REGENERATION
    PETER MACLEISH; Fiscal Year: 2004
    ..The health relatedness is to understand the molecular cascades required for successful regeneration so that effective treatment strategies can be designed to treat patients suffering from neural injury. ..
  34. GROWTH PLATE CELLULAR FUNCTION FOLLOWING RADIOTHERAPY
    Timothy Damron; Fiscal Year: 2008
    ..abstract_text> ..
  35. Imaging neural networks in mouse somatosensory cortex
    JOSHUA BRUMBERG; Fiscal Year: 2003
    ..g. schizophrenia) works, and thus possibly lead towards the development of new therapeutic interventions. ..
  36. Tanning bed use among UI Students
    Leslie Dennis; Fiscal Year: 2003
    ..abstract_text> ..
  37. FUNCTIONAL AND HEALTH CHANGES OF THE ELDERLY
    Kenneth Manton; Fiscal Year: 2002
    ....
  38. Conditioning-specific reflex modification
    BERNARD SCHREURS; Fiscal Year: 2004
    ..abstract_text> ..
  39. Conference on Photodynamic Therapy
    David Kessel; Fiscal Year: 2002
    ..The most recent PDT meeting, sponsored by the International Photodynamic Assn, has more than 600 participants. ..
  40. Use of Clenbuterol for Enhancement of Stem Cell Therapy
    Richard Zeman; Fiscal Year: 2002
    ..The method will be patented, licensed and marketed as a new therapy. ..
  41. Mechanisms of Radiation-Induced Genomic Istability
    William Morgan; Fiscal Year: 2005
    ....
  42. Improved MRI Contrast Agents
    James Hainfeld; Fiscal Year: 2002
    ..Furthermore, the development of targeted agents could functionally distinguish between benign and malignant tumors and be used to diagnose many other conditions...
  43. Use of Albuterol in Spinal Cord Injury
    Richard Zeman; Fiscal Year: 2002
    ..PROPOSED COMMERCIAL APPLICATION: Use of beta 2-agonists like albuterol alone or together with x-irradiation maybe useful therapies for spinal cord injuries. ..
  44. 2003 Genetic Toxicology Gordon Conference
    Penny Jeggo; Fiscal Year: 2003
    ..We particularly air to obtain funding to support applications from minority groupings and younger scientists. We have already identified a significant participation of women amongst our list of speakers. ..
  45. Electromagnetic Tracking of Tumors for Radiotherapy
    Martin Murphy; Fiscal Year: 2006
    ..The augmented Calypso targeting system will be designed for integration into existing radiation therapy systems to provide enhanced beam targeting capability. [unreadable] [unreadable]..
  46. RADIATION INDUCED THYROID CANCER
    ARTHUR SCHNEIDER; Fiscal Year: 2002
    ..These studies will focus on rearrangements of the ret protooncogene in thyroid neoplasms and the NF2 tumor suppressor gene in neural tumors. ..
  47. Interaction of AIDS-associated microbes with radiation
    Ekaterina Dadachova; Fiscal Year: 2009
    ..Such knowledge will contribute to development of a novel therapeutic modality based on radioimmunotherapy for treatment of currently incurable or multidrug-resistant AIDS-associated opportunistic infections. ..
  48. DEMOGRAPHIC STUDY OF MULTIPLE CAUSES OF DEATH
    Kenneth Manton; Fiscal Year: 2008
    ..S. population ages and the numbers of nonagenarians and centenarians increase. This is important in forecasting life expectancy and the growth of he extreme elderly U.S. population. ..
  49. MONTE CARLO SIMULATION OF HIGH ENERGY PHOTON IMAGING
    Yuni Dewaraja; Fiscal Year: 2001
    ..Apart from quantification, this work will have applications in the design of future imaging systems for high energy photons. ..
  50. DBS and Rodent Antidepressant- Screen Models
    Ziad Nahas; Fiscal Year: 2008
    ..Future work will bridge between validating these findings in more comprehensive models of depression and clinical investigations of the DBS antidepressant effect in patients with treatment resistant depression. ..
  51. 2007 Oculomotor System Biology Gordon Research Conference
    Neeraj Gandhi; Fiscal Year: 2007
    ..Other disorders such as congenital fibrosis can also alter mechanistic properties of the extraocular muscle itself. Hence, the oculomotor system is of immense relevance to health. [unreadable] [unreadable] [unreadable] [unreadable]..
  52. Telomere-Mediated Protective Responses in Skin
    Barbara Gilchrest; Fiscal Year: 2007
    ..The studies will also explore the possible therapeutic potential of T-oligos that comparably induce these responses in the absence of actual DNA damage or telomere disruption. ..
  53. Thyroid Disease in People Exposed to Radioactive Fallout
    JOSEPH LYON; Fiscal Year: 2004
    ..Abstract not provided ..
  54. Use of Tempol for Spinal Cord Injury
    Richard Zeman; Fiscal Year: 2004
    ..Optimization of tempol treatment may lead to a therapeutic modality for SCI. ..
  55. 2005 (Oculomotor System Biology) Gordon Conference
    Neeraj Gandhi; Fiscal Year: 2005
    ..Hence, we seek to bring together ideas and investigators that are not often at the same venue. ..
  56. Motor Unit Activity and Force Steadiness Changes w Aging
    Lisa Griffin; Fiscal Year: 2007
    ..This elucidation of the neuromuscular mechanisms that enable hand steadiness will provide the foundation for the design of advanced rehabilitation systems. ..
  57. Role of NTS POMC neurons in energy homeostasis
    SUZANNE APPLEYARD; Fiscal Year: 2008
    ..abstract_text> ..
  58. MELANOMA CONTROL FOR SIBLING OF MELANOMA PATIENTS
    Barbara Gilchrest; Fiscal Year: 2001
    ....
  59. Barrels XX
    JOSHUA BRUMBERG; Fiscal Year: 2007
    ..The meeting program is composed if long talks (30 min) by established researchers and shorter talks by more junior individuals (15 min) and a poster session. [unreadable] [unreadable] [unreadable]..
  60. Telomere homolog oligonucleotides for cancer therapy
    Barbara Gilchrest; Fiscal Year: 2004
    ..abstract_text> ..
  61. Protein Biomarkers of Cancer Risk in Older Persons
    Christopher Li; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  62. c-erbB-2 and Risk of Contralateral Breast Cancer
    Christopher Li; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  63. Depo-Provera and Breast Cancer: Epidemiology/Pathology
    Christopher Li; Fiscal Year: 2009
    ..such as parity and body mass index, modify this association?;and (3) Does the association between DMPA and breast cancer risk vary by histologic type or by the expression of steroid receptors including ERq, ERft, and PR? ..
  64. Outcomes Research and Training in Oncology
    James Talcott; Fiscal Year: 2005
    ..One approach to these issues is to identify differences in outcomes based on the mode of diagnosis (screening vs. investigation of symptoms). ..