body burden

Summary

Summary: The total amount of a chemical, metal or radioactive substance present at any time after absorption in the body of man or animal.

Top Publications

  1. pmc Multiple environmental chemical exposures to lead, mercury and polychlorinated biphenyls among childbearing-aged women (NHANES 1999-2004): Body burden and risk factors
    Marcella Remer Thompson
    Superfund Research Program, Brown University, Providence, Rhode Island, USA
    Environ Res 121:23-30. 2013
  2. pmc Polychlorinated biphenyl (PCB) exposure and diabetes: results from the Anniston Community Health Survey
    Allen E Silverstone
    State University of New York Upstate Medical University, Syracuse, New York 13210, USA
    Environ Health Perspect 120:727-32. 2012
  3. ncbi Environmental lead exposure and progressive renal insufficiency
    J L Lin
    Poison Center and Division of Nephrology, Chang Gung Memorial Hospital, 199, Tung Hwa North Road, Taipei, Taiwan, Republic of China
    Arch Intern Med 161:264-71. 2001
  4. pmc Impact of dust from multiple microenvironments and diet on PentaBDE body burden
    Deborah J Watkins
    Center for Environmental Health and Technology, Brown University, Providence, Rhode Island, United States
    Environ Sci Technol 46:1192-200. 2012
  5. pmc Prevalence of metabolic syndrome associated with body burden levels of dioxin and related compounds among Japan's general population
    Hirokazu Uemura
    Department of Preventive Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Environ Health Perspect 117:568-73. 2009
  6. pmc Renal effects of environmental and occupational lead exposure
    M Loghman-Adham
    Division of Nephrology and Hypertension, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Environ Health Perspect 105:928-38. 1997
  7. ncbi Comparative chlorpyrifos pharmacokinetics via multiple routes of exposure and vehicles of administration in the adult rat
    Jordan Ned Smith
    Battelle, Pacific Northwest Division, Richland, WA 99354, USA
    Toxicology 261:47-58. 2009
  8. ncbi Evaluation of (137)Cs body burden in inhabitants of Bryansk Oblast, Russian Federation, where a high incidence of thyroid cancer was observed after the accident at the Chernobyl nuclear power plant
    Yui Sekitani
    Department of Radiation Epidemiology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8523, Japan
    Radiat Prot Dosimetry 141:36-42. 2010
  9. ncbi Smoking-induced increase in urinary cadmium levels among Japanese women
    M Ikeda
    Kyoto Industrial Health Association, Nakagyo ku, Kyoto 604 8472, Japan
    Int Arch Occup Environ Health 78:533-40. 2005
  10. ncbi Long-term follow-up of the 137Cs body burden of individuals after the Chernobyl accident--a means for the determination of biological half-lives
    W Ruhm
    Federal Office for Radiation Protection, Institute for Radiation Hygiene, Oberschleissheim, Germany
    Health Phys 77:373-82. 1999

Detail Information

Publications286 found, 100 shown here

  1. pmc Multiple environmental chemical exposures to lead, mercury and polychlorinated biphenyls among childbearing-aged women (NHANES 1999-2004): Body burden and risk factors
    Marcella Remer Thompson
    Superfund Research Program, Brown University, Providence, Rhode Island, USA
    Environ Res 121:23-30. 2013
    ..and polychlorinated biphenyls (PCBs) are neurotoxicants with intergenerational health consequences from maternal body burden and gestational exposures. Little is known about multiple chemical exposures among childbearing-aged women.
  2. pmc Polychlorinated biphenyl (PCB) exposure and diabetes: results from the Anniston Community Health Survey
    Allen E Silverstone
    State University of New York Upstate Medical University, Syracuse, New York 13210, USA
    Environ Health Perspect 120:727-32. 2012
    ..Polychlorinated biphenyls (PCBs) manufactured in Anniston, Alabama, from 1929 to 1971 caused significant environmental contamination. The Anniston population remains one of the most highly exposed in the world...
  3. ncbi Environmental lead exposure and progressive renal insufficiency
    J L Lin
    Poison Center and Division of Nephrology, Chang Gung Memorial Hospital, 199, Tung Hwa North Road, Taipei, Taiwan, Republic of China
    Arch Intern Med 161:264-71. 2001
    ..Several recent studies show that serum creatinine level or creatinine clearance is inversely associated with blood lead levels. However, the studies did not allow direct inferences about causality...
  4. pmc Impact of dust from multiple microenvironments and diet on PentaBDE body burden
    Deborah J Watkins
    Center for Environmental Health and Technology, Brown University, Providence, Rhode Island, United States
    Environ Sci Technol 46:1192-200. 2012
    ..were to determine relative contributions of diet and dust exposure from multiple microenvironments to PentaBDE body burden, and to explore the role of handwipes as a measure of personal exposure to PentaBDE...
  5. pmc Prevalence of metabolic syndrome associated with body burden levels of dioxin and related compounds among Japan's general population
    Hirokazu Uemura
    Department of Preventive Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Environ Health Perspect 117:568-73. 2009
    ..Environmental exposure to some persistent organic pollutants has been reported to be associated with a metabolic syndrome in the U.S. population...
  6. pmc Renal effects of environmental and occupational lead exposure
    M Loghman-Adham
    Division of Nephrology and Hypertension, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Environ Health Perspect 105:928-38. 1997
    ..The EDTA lead mobilization test has been used extensively in the past to assess body lead burden. It is now replaced by the less invasive in vivo X-ray fluorescence for determination of bone lead content...
  7. ncbi Comparative chlorpyrifos pharmacokinetics via multiple routes of exposure and vehicles of administration in the adult rat
    Jordan Ned Smith
    Battelle, Pacific Northwest Division, Richland, WA 99354, USA
    Toxicology 261:47-58. 2009
    ..This is of particular importance when comparing studies that use varying exposure paradigms, which are then used for extrapolation of risk to humans...
  8. ncbi Evaluation of (137)Cs body burden in inhabitants of Bryansk Oblast, Russian Federation, where a high incidence of thyroid cancer was observed after the accident at the Chernobyl nuclear power plant
    Yui Sekitani
    Department of Radiation Epidemiology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8523, Japan
    Radiat Prot Dosimetry 141:36-42. 2010
    To determine the current risk of internal radiation exposure after the Chernobyl accident, the (137)Cs body burden of the inhabitants of Bryansk Oblast, Russian Federation was evaluated, from 1998 to 2008...
  9. ncbi Smoking-induced increase in urinary cadmium levels among Japanese women
    M Ikeda
    Kyoto Industrial Health Association, Nakagyo ku, Kyoto 604 8472, Japan
    Int Arch Occup Environ Health 78:533-40. 2005
    ..To examine if cigarette smoking will induce elevation in cadmium (Cd) in urine...
  10. ncbi Long-term follow-up of the 137Cs body burden of individuals after the Chernobyl accident--a means for the determination of biological half-lives
    W Ruhm
    Federal Office for Radiation Protection, Institute for Radiation Hygiene, Oberschleissheim, Germany
    Health Phys 77:373-82. 1999
    ..Since body mass, for example, is a parameter very simple to measure, the given correlations are useful for practical purposes...
  11. ncbi Background exposure to PCDDs/PCDFs/PCBs and its potential health effects: a review of epidemiologic studies
    Kokichi Arisawa
    Department of Preventive Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    J Med Invest 52:10-21. 2005
    Here we review epidemiologic studies dealing with the dietary intake and the body burden of polychlorinated dibenzo-p-dioxins (PCDDs)/polychlorinated dibenzo-furans (PCDFs)/ polychlorinated biphenyls (PCBs) in the general population, and ..
  12. pmc Association between hemochromatosis genotype and lead exposure among elderly men: the normative aging study
    Robert O Wright
    Department of Pediatrics, Children s Hospital, Boston, Massachusetts 02115, USA
    Environ Health Perspect 112:746-50. 2004
    ..Among elderly men, subjects with HFE variants had lower patella lead levels. These effects may be mediated by alterations in lead toxicokinetics via iron metabolic pathways regulated by the HFE gene product and body iron stores...
  13. pmc Diet contributes significantly to the body burden of PBDEs in the general U.S. population
    Alicia J Fraser
    Boston University School of Public Health, Department of Environmental Health, Boston, Massachusetts, USA
    Environ Health Perspect 117:1520-5. 2009
    ..Exposure of the U.S. population to polybrominated diphenyl ethers (PBDEs) is thought to be via exposure to dust and diet. However, little work has been done to empirically link body burdens of these compounds to either route of exposure...
  14. ncbi MIRD dose estimate report No. 20: radiation absorbed-dose estimates for 111In- and 90Y-ibritumomab tiuxetan
    Darrell R Fisher
    Radioisotopes Program, Pacific Northwest National Laboratory, Richland, Washington, USA
    J Nucl Med 50:644-52. 2009
    ..In this study, we evaluated the organ radiation absorbed doses from intravenously administered (111)In- and (90)Y-ibritumomab tiuxetan...
  15. ncbi Internal phthalate exposure over the last two decades--a retrospective human biomonitoring study
    Matthias Wittassek
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Germany
    Int J Hyg Environ Health 210:319-33. 2007
    ....
  16. pmc New evidence on variations of human body burden of methylmercury from fish consumption
    René Canuel
    Institute of Environmental Sciences, Universite du Quebec a Montreal, Montreal, Quebec, Canada
    Environ Health Perspect 114:302-6. 2006
    ..This finding could be explained by differences in specific genetic characteristics and/or interactive effects of other dietary components...
  17. ncbi American College of Radiology white paper on radiation dose in medicine
    E Stephen Amis
    Albert Einstein College of Medicine Montefiore Medical Center, Bronx, NY, USA
    J Am Coll Radiol 4:272-84. 2007
    ..This white paper details a proposed action plan for the college derived from the deliberations of that panel...
  18. ncbi Human exposure to PBDEs: associations of PBDE body burdens with food consumption and house dust concentrations
    Nerissa Wu
    Department of Environmental Health Talbot 2E, Boston University School of Public Health, 715 Albany Street, Boston, Massachusetts 02118, USA
    Environ Sci Technol 41:1584-9. 2007
    This study was designed to determine the body burden of polybrominated diphenyl ethers (PBDEs) among first-time mothers in the Greater Boston, Massachusetts area and to explore key routes of exposure...
  19. pmc Evaluating cumulative organophosphorus pesticide body burden of children: a national case study
    Devon Payne-Sturges
    National Center for Environmental Research, US Environmental Protection Agency, Washington, DC 20460 0001, USA
    Environ Sci Technol 43:7924-30. 2009
    ..a methodology for a health risk interpretation of biomonitoring data and to apply it using NHANES 1999-2002 body burden data fororganophosphorus (OP) pesticides...
  20. ncbi Towards an understanding of the link between environmental emissions and human body burdens of PCBs using CoZMoMAN
    Knut Breivik
    Norwegian Institute for Air Research, P O Box 100, NO 2027 Kjeller, Norway
    Environ Int 36:85-91. 2010
    ..An integrated, non-steady state model calculating human body burden from environmental emissions (CoZMoMAN) was created by linking the multi-compartment environmental fate model ..
  21. ncbi Creatinine versus specific gravity-adjusted urinary cadmium concentrations
    Y Suwazono
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Biomarkers 10:117-26. 2005
    ..When comparing individuals or populations with large differences in muscle mass or meat intake, such effects can be especially important. In such studies, specific gravity adjustment seems to be more appropriate...
  22. ncbi The toxicological response of Brazilian chrysotile asbestos: a multidose subchronic 90-day inhalation toxicology study with 92-day recovery to assess cellular and pathological response
    David M Bernstein
    Rogers Imaging Corporation, Needham, Massachusetts, USA
    Inhal Toxicol 18:313-32. 2006
    ..S. threshold limit value of 0.1 f(WHO)/cm3, chrysotile produces no significant pathological response...
  23. ncbi Prediction of the bioaccumulation factors and body burden of natural and synthetic estrogens in aquatic organisms in the river systems
    K M Lai
    Environmental Processes and Water Technology Group, T H Huxley School of the Environment, Earth Science and Engineering, Imperial College of Science, Technology and Medicine, London, UK
    Sci Total Environ 289:159-68. 2002
    This study undertakes an initial prediction of the bioaccumulation factors and body burden of the steroid estrogens, estrone, estradiol, estriol and ethinylestradiol in a range of aquatic organisms (plankton, benthic and free-living ..
  24. ncbi Potential exposure assessment errors associated with body-worn RF dosimeters
    Juan Blas
    CEDETEL, Edificio Solar, Parque Tecnologico de Boecillo, Boecillo, Valladolid, Spain
    Bioelectromagnetics 28:573-6. 2007
    ..We present several guidelines to address this issue and a useful insight into the overall problem based on finite-difference time-domain simulations and experimental verification...
  25. ncbi Body burden of metals and persistent organic pollutants among Inuit in the Canadian Arctic
    Brian D Laird
    Center for Advanced Research in Environmental Genomics, University of Ottawa, 20 Marie Curie, Ottawa, ON Canada
    Environ Int 59:33-40. 2013
    ..The body burden of metals (e.g. Cd, Pb) and persistent organic pollutants (e.g...
  26. ncbi Exposure of the Swiss population by radiodiagnostics: 2003 review
    A Aroua
    University Institute of Applied Radiation Physics, Grand pré 1, 1007 Lausanne, Switzerland
    Health Phys 92:442-8. 2007
    ..Both changes in the frequency and the effective dose per examination led to a 20% increase in the total collective dose...
  27. ncbi Evaluation of image quality and radiation dose of thoracic and coronary dual-source CT in 110 infants with congenital heart disease
    Moez Ben Saad
    Radiology Department, CC Marie Lannelongue, 133 av de la Résistance, Plessis Robinson, 92350, France
    Pediatr Radiol 39:668-76. 2009
    ..There are only a few reports on the diagnostic accuracy, and the technical and clinical feasibility, of multidetector CT (MDCT) in infants with congenital heart disease (CHD)...
  28. pmc Cadmium-related mortality and long-term secular trends in the cadmium body burden of an environmentally exposed population
    Tim S Nawrot
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Herestraat 49, Leuven, Belgium
    Environ Health Perspect 116:1620-8. 2008
    ..Few population studies have reported on the long-term changes in the internal cadmium dose and simultaneously occurring mortality...
  29. pmc Polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls in fishermen in Finland
    Hannu Kiviranta
    National Public Health Institute, Department of Environmental Health, Kuopio, Finland
    Environ Health Perspect 110:355-61. 2002
    ..The body burden of PCDD/Fs reached the median level of 170 pg/g toxic equivalents (I-TEq) in fat for Baltic Sea fishermen, with ..
  30. ncbi Environmental lead exposure and urate excretion in the general population
    Ja Liang Lin
    Poison Center, Chang Gung Memorial Hospital, Lin Kou Medical Center, Chang Gung Medical College and University, 199 Tung Hwa North Road, Taipei, Taiwan, ROC
    Am J Med 113:563-8. 2002
    ..However, whether chronic low-level environmental lead exposure influences urate excretion in the general population remains unknown...
  31. pmc Menopause and lead body burden among US women aged 45-55, NHANES 1999-2010
    Pauline Mendola
    Epidemiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6100 Executive Blvd, Rockville, MD 20852, USA
    Environ Res 121:110-3. 2013
    ..Environmental factors in menopause have received limited attention. Lead is a known reproductive toxicant associated with delayed puberty in girls that may also affect menopause...
  32. ncbi Individual variation in body burden, lipid status, and reproductive investment is related to maternal transfer of a brominated diphenyl ether (BDE-99) to eggs in the zebra finch
    Margaret L Eng
    Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia, Canada
    Environ Toxicol Chem 32:345-52. 2013
    ..transfer of contaminants within a species is influenced by individual variation in characteristics such as body burden, yolk precursor levels, or reproductive investment is not understood...
  33. ncbi The contribution of diet to total bisphenol A body burden in humans: results of a 48 hour fasting study
    K L Y Christensen
    National Center for Environmental Assessment, Office of Research and Development, United States Environmental Protection Agency, Washington, DC, USA
    Environ Int 50:7-14. 2012
    ..On day 2, non-dietary sources may still be present, such as from dust. Another hypothesis is that small reservoirs of BPA from past exposures are released from storage (lipid reservoirs, e.g.) and excreted...
  34. pmc Understanding differences in the body burden-age relationships of bioaccumulating contaminants based on population cross sections versus individuals
    Cristina L Quinn
    Department of Chemistry, University of Toronto Scarborough, Toronto, Ontario, Canada
    Environ Health Perspect 120:554-9. 2012
    ..Such relationships have previously been assumed to reflect the role of age in bioaccumulation...
  35. ncbi Screening for 137Cs body burden due to the Chernobyl accident in Korosten City, Zhitomir, Ukraine: 1996-2008
    Naomi Hayashida
    Department of Global Health, Medicine and Welfare, Nagasaki University Graduate School of Biomedical Sciences, Japan
    J Radiat Res 52:629-33. 2011
    ..The total number of participants was 144,972 (96,149 females and 48,823 males). The median body burden of (137)Cs per body weight decreased from 1996 to 2008...
  36. ncbi Body burden of aluminum in relation to central nervous system function among metal inert-gas welders
    V Riihimaki
    Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Helsinki
    Scand J Work Environ Health 26:118-30. 2000
    ..The relationship between elevated internal aluminum loads and central nervous system function was studied among aluminum welders, and the threshold level for adverse effect was defined...
  37. ncbi Exposure of populations to dioxins and related compounds
    A K Liem
    National Institute of Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Food Addit Contam 17:241-59. 2000
    ....
  38. ncbi Congener-specific body burden levels and possible determinants of polybrominated diphenyl ethers in the general Japanese population
    Hirokazu Uemura
    Department of Preventive Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770 8503, Japan
    Chemosphere 79:706-12. 2010
    Our objective was to investigate congener-specific body burden levels and possible determinants of polybrominated diphenyl ethers (PBDEs) in the Japanese human population.
  39. ncbi Dose estimation software for radiation biodosimetry
    Elizabeth A Ainsbury
    Health Protection Agency Centre for Radiation, Chemical and Environmental Hazards, Chilton, Didcot, Oxfordshire OX11 0RQ England
    Health Phys 98:290-5. 2010
    ..Proposals for improving the software through implementation of recently published Bayesian analysis techniques for cytogenetics are also outlined. An evaluation copy of the software is available on request from the authors...
  40. ncbi Di-n-butylphthalate and butylbenzylphthalate - urinary metabolite levels and estimated daily intakes: pilot study for the German Environmental Survey on children
    Holger M Koch
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Erlangen, Germany
    J Expo Sci Environ Epidemiol 17:378-87. 2007
    ..For both phthalates and independent of the model, we found increasing daily intakes with decreasing age. Between 25% (creatinine model) and 50% (volume model) of the 2-4-year old children had daily intakes for DnBP above the TDI...
  41. pmc Environmental exposure to polychlorinated biphenyls and placental CYP1A1 activity in Inuit women from northern Québec
    Daria Pereg
    Département de Biologie médicale, Faculte de Medecine, Université Laval et Unité de recherche en santé et environnement, Ste Foy, Quebec, Canada
    Environ Health Perspect 110:607-12. 2002
    ..The objective of this study was to determine if the body burden of PCBs is related to placental CYP1A1 activity in Inuit women from Nunavik (northern Québec), a population ..
  42. pmc Does long term residency near industry have an impact on the body burden of polychlorinated dibenzo-p-dioxins, furans, and polychlorinated biphenyls in older women?
    T Pless-Mulloli
    School of Population and Health Sciences, The Medical School, Newcastle upon Tyne, UK
    Occup Environ Med 62:895-901. 2005
    ..Polychlorinated dibenzo-dioxins and furans (PCDD/F) and polychlorinated biphenyls (PCBs) have been useful markers in some settings. This is the first study of PCDD/F body burden in a population based sample from the UK.
  43. ncbi Organ dose conversion coefficients for voxel models of the reference male and female from idealized photon exposures
    H Schlattl
    GSF National Research Center for Environment and Health, Institute of Radiation Protection, Ingolstadter Landstr 1, 85764 Neuherberg, Germany
    Phys Med Biol 52:2123-45. 2007
    ....
  44. ncbi Accounting for differing exposure patterns between laboratory tests and the field in the assessment of long-term risks of pesticides to terrestrial vertebrates
    David L Fischer
    Ecotoxicology Section, Research and Development Department, Bayer CropScience LLC, 17745 South Metcalf Avenue, Stilwell, Kansas 66085, USA
    Ecotoxicology 14:853-62. 2005
    ..Such tests may also be useful testing the validity of each of these assessment methods...
  45. ncbi Lactation and lead body burden turnover: a pilot study in Mexico
    J Moline
    Department of Community and Preventive Medicine, Mount Sinai Medical Center, New York, NY, USA
    J Occup Environ Med 42:1070-5. 2000
    A pilot study was conducted in Morelos, Mexico in March 1999 to assess the body burden of lead in 24 Mexican women of childbearing age...
  46. ncbi Radiopharmaceuticals for nuclear cardiology: radiation dosimetry, uncertainties, and risk
    Michael G Stabin
    Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee 37232 2675, USA
    J Nucl Med 49:1555-63. 2008
    ..Also discussed is the issue of uncertainties in radiation dose estimates and how to compare the relative risks of studies...
  47. ncbi Reduction in the body content of DDE in the Mongolian gerbil treated with sucrose polyester and caloric restriction
    L C Mutter
    Division of Clinical Toxicology and Environmental Medicine, Medical College of Virginia, Richmond 23298
    Toxicol Appl Pharmacol 92:428-35. 1988
    ..We conclude that stimulation of intestinal excretion may offer a new approach to treatment of patients exposed to lipophilic environmental contaminants...
  48. ncbi TEQ(S) and body burden for PCDDs, PCDFs, and dioxin-like PCBs in human adipose tissue
    Cinzia La Rocca
    Department of Food Safety and Veterinary Public Health, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Chemosphere 73:92-6. 2008
    ..The obese body burdens varied from 6 to 11 ng TEQ kg(-1) body weight (BW), exceeding the estimated steady-state body burden 5 ng TEQ kg(-1) BW, based on lipid adjusted serum concentrations from several populations in the mid-1990s, ..
  49. ncbi Radiation-absorbed dose from 201Tl-thallous chloride
    Stephen R Thomas
    Department of Radiology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267 0579, USA
    J Nucl Med 46:502-8. 2005
    ....
  50. ncbi Effects of variations in cadmium and lead levels in river sediments on local foods and body burden of local residents in non-polluted areas in Japan
    Masayuki Ikeda
    Kyoto Industrial Health Association, 67 Nishinokyo Kitatsuboicho, Nakagyo ku, Kyoto, 604 8472, Japan
    Biol Trace Elem Res 133:255-64. 2010
    ..concentrations of cadmium (Cd) and lead (Pb) in water environment may affect metal levels in local foods and body burden of local residents in non-polluted areas in Japan...
  51. ncbi Tissue-specific distribution and whole-body burden estimates of persistent organic pollutants in the bottlenose dolphin (Tursiops truncatus)
    Jennifer E Yordy
    Marine Biomedicine and Environmental Sciences Center, Medical University of South Carolina, 221 Fort Johnson Rd, Charleston, South Carolina 29412, USA
    Environ Toxicol Chem 29:1263-73. 2010
    ..This unique physiological adaptation should be taken into consideration when assessing contaminant-related health effects in wild cetacean populations...
  52. ncbi Body burden of POPs of Hong Kong residents, based on human milk, maternal and cord serum
    Hin L Tsang
    Croucher Institute for Environmental Sciences, and Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, PR China
    Environ Int 37:142-51. 2011
    ..Human milk is a reliable and comparatively non-invasive tool for monitoring body loading of POPs, which also allows health risk assessment of residual chemicals on our next generation...
  53. ncbi A role for the body burden of aluminium in vaccine-associated macrophagic myofasciitis and chronic fatigue syndrome
    Christopher Exley
    Birchall Centre for Inorganic Chemistry and Materials Science, Keele University, Staffordshire ST5 5BG, UK
    Med Hypotheses 72:135-9. 2009
    ....
  54. ncbi Neurosensory effects of chronic human exposure to arsenic associated with body burden and environmental measures
    D Otto
    Human Studies Division, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Hum Exp Toxicol 26:169-77. 2007
    ..Drinking water, urine and toenail samples were obtained to assess arsenic exposure and body burden. Regression analyses indicated significant associations of pinprick scores and vibration thresholds with all ..
  55. pmc Dose-response relationship of prenatal mercury exposure and IQ: an integrative analysis of epidemiologic data
    Daniel A Axelrad
    Office of Policy, Economics, and Innovation, U S Environmental Protection Agency, 1200 Pennsylvania Avenue NW, Washington, DC 20460, USA
    Environ Health Perspect 115:609-15. 2007
    ..Prenatal exposure to mercury has been associated with adverse childhood neurologic outcomes in epidemiologic studies. Dose-response information for this relationship is useful for estimating benefits of reduced mercury exposure...
  56. pmc Cancer risks following diagnostic and therapeutic radiation exposure in children
    Ruth A Kleinerman
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, EPS 7044, 6120 Executive Blvd, Rockville, MD 20852, USA
    Pediatr Radiol 36:121-5. 2006
    ..Risks of radiation-related cancer are greatest for those exposed early in life, and these risks appear to persist throughout life...
  57. ncbi Occupational radiation doses in interventional cardiology: a 15-year follow-up
    E Vano
    Department of Radiology, Complutense University Medical School 28040 Madrid, Spain
    Br J Radiol 79:383-8. 2006
    ....
  58. ncbi Prevalence of diabetes and body burdens of polychlorinated biphenyls, polybrominated diphenyl ethers, and p,p'-diphenyldichloroethene in Great Lakes sport fish consumers
    Mary Turyk
    University of Illinois at Chicago, 60612, United States
    Chemosphere 75:674-9. 2009
    ..The current study confirms previous cross sectional associations of DDE exposure with diabetes. Future studies should address biologic pathways by which selective POPs affect glucose homeostasis...
  59. ncbi Polybrominated diphenyl ether (PBDE) flame retardants: environmental contamination, human body burden and potential adverse health effects
    Lucio G Costa
    Department of Human Anatomy, Pharmacology, and Forensic Science, University of Parma Medical School, Parma, Italy
    Acta Biomed 79:172-83. 2008
    ..Infants and toddlers have the highest body burden, due to exposure via maternal milk and through house dust...
  60. ncbi A comparison of (111)In-DOTATOC and (111)In-DOTATATE: biodistribution and dosimetry in the same patients with metastatic neuroendocrine tumours
    F Forrer
    Institute of Nuclear Medicine, University Hospital, Petersgraben 4, 4031, Basel, Switzerland
    Eur J Nucl Med Mol Imaging 31:1257-62. 2004
    ....
  61. ncbi Human exposure to polybrominated diphenyl ethers (PBDE), as evidenced by data from a duplicate diet study, indoor air, house dust, and biomonitoring in Germany
    Hermann Fromme
    Department of Environmental Health, Bavarian Health and Food Safety Authority, Veterinärstrasse 2, D 85764 Oberschleissheim, Germany
    Environ Int 35:1125-35. 2009
    ..Using a simplified toxicokinetic model to predict the body burden from exposure doses led to results that were of the same order of magnitude as the measured blood ..
  62. pmc Pulmonary clearance of UICC amosite fibres inhaled by rats during chronic exposure at low concentration
    A D Jones
    Institute of Occupational Medicine, Edinburgh, UK
    Br J Ind Med 45:300-4. 1988
    ..The latest results reported here support the application of such a model to lower exposure concentrations closer to those of asbestos in workplaces...
  63. ncbi Pre-therapeutic dosimetry and biodistribution of 86Y-DOTA-Phe1-Tyr3-octreotide versus 111In-pentetreotide in patients with advanced neuroendocrine tumours
    Andreas Helisch
    Department of Nuclear Medicine, University of Mainz, Mainz, Germany
    Eur J Nucl Med Mol Imaging 31:1386-92. 2004
    ....
  64. ncbi Body burden of contaminants and biological effects in mussels: an integrated approach
    Phil Yeats
    Marine Chemistry Section, Ecosystem Research Division, Bedford Institute of Oceanography, Department of Fisheries and Oceans P O Box 1006, Dartmouth, Nova Scotia, Canada B2Y 4A2
    Environ Int 34:254-64. 2008
    ..The aim of the study was to compare the body burden of mussels in terms of polycyclic aromatic hydrocarbons (PAH), dichlorophenyltrichloroethane (DDT family), ..
  65. pmc A biopersistence study following exposure to chrysotile asbestos alone or in combination with fine particles
    D M Bernstein
    University of Edinburgh, ELEGI Colt Laboratory, Edinburgh, Scotland
    Inhal Toxicol 20:1009-28. 2008
    ..The increased number of macrophages in the chrysotile/sanded joint exposure group was confirmed histologically, with this being the only exposure-related histological finding reported...
  66. ncbi Radiation dose estimates in humans for (11)C-acetate whole-body PET
    Marc A Seltzer
    Department of Molecular and Medical Pharmacology, Ahmanson Biological Imaging Center, University of California at Los Angeles School of Medicine, Los Angeles, California, USA
    J Nucl Med 45:1233-6. 2004
    ..Dynamic whole-body (11)C-acetate PET was therefore performed on 6 healthy human volunteers. Measured dose estimates for all target organs were compared with the existing ORISE values...
  67. ncbi Body burden of mercury is associated with acute atopic eczema and total IgE in children from southern Germany
    Stephan Weidinger
    J Allergy Clin Immunol 114:457-9. 2004
  68. pmc PCDD/PCDF: human background data for Germany, a 10-year experience
    O Papke
    ERGO Forschungsgesellschaft mbH, Hamburg, Germany
    Environ Health Perspect 106:723-31. 1998
    ..of factors such as various eating habits, severe weight loss, age, and nursing (women only) on the human body burden is discussed...
  69. ncbi Asbestos content of omentum and mesentery in nonoccupationally exposed individuals
    R F Dodson
    The University of Texas Health Center at Tyler, Tyler, Texas 75708, USA
    Toxicol Ind Health 17:138-43. 2001
    ..The findings, when compared with previous data from occupationally exposed individuals, indicate extreme contrasts as to the level and types of fiber burden between individuals representing the groups...
  70. ncbi Tissue burden of asbestos in nonoccupationally exposed individuals from east Texas
    R F Dodson
    Department of Cell Biology and Environmental Sciences, University of Texas Health Center at Tyler 75708 3154, USA
    Am J Ind Med 35:281-6. 1999
    ..The potential for asbestos exposure among members of the general population is appreciable, considering its widespread use in many products. This study examined tissue burden of asbestos in such a population...
  71. ncbi Absorbed dose to the adult male and female brain from 18F-fluorodeoxyglucose
    E Niven
    Department of Nuclear Medicine, McMaster University of Medical Center, Hamilton, Ontario, Canada
    Health Phys 80:62-6. 2001
    ..The average variation in the self-dose for all 12 patients was found to be within 14%, suggesting that in most cases this method of obtaining a single dose estimate is precise...
  72. ncbi Fingernail may not be a reliable biomarker of fluoride body burden from dentifrice
    Ynara Bosco Oliveira Lima-Arsati
    São Leopoldo Mandic School of Dentistry and Research Center, Campinas, SP, Brazil
    Braz Dent J 21:91-7. 2010
    Fingernail has been suggested as a biomarker of fluoride (F) body burden, but there is no consensus if it would be a reliable indicator of F exposure from dentifrice...
  73. pmc Human biodistribution and radiation dosimetry of 82Rb
    Srinivasan Senthamizhchelvan
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology, Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Nucl Med 51:1592-9. 2010
    ..Prior estimates of radiation-absorbed doses from (82)Rb, a frequently used PET perfusion tracer, yielded discrepant results. We reevaluated (82)Rb dosimetry using human in vivo biokinetic measurements...
  74. ncbi PCDDs/PCDFs and dioxin-like PCBs: recent body burden levels and their determinants among general inhabitants in Japan
    Hirokazu Uemura
    Department of Preventive Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15, Kuramoto Cho, Tokushima 770 8503, Japan
    Chemosphere 73:30-7. 2008
    The objective was to grasp the recent body burden levels of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and dioxin-like polychlorinated biphenyls (DL-PCBs) and to investigate their determinants among ..
  75. ncbi New calculations for internal dosimetry of beta-emitting radiopharmaceuticals
    M Zankl
    Institute of Radiation Protection, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
    Radiat Prot Dosimetry 139:245-9. 2010
    ..Only for irradiation of the urinary bladder wall by activity in the contents, the ICRP 30 approach presents an overestimation of approximately 40-50%...
  76. pmc Developmental neurotoxicity of polybrominated diphenyl ether (PBDE) flame retardants
    Lucio G Costa
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, United States
    Neurotoxicology 28:1047-67. 2007
    ..Levels of PBDEs causing developmental neurotoxicity in animals are not much dissimilar from levels found in highly exposed infants and toddlers...
  77. ncbi Electromagnetic field measurements using personal exposimeters
    Urs Knafl
    Environment and Electromagnetic Compatibility, Swisscom Innovations, Bern, Switzerland
    Bioelectromagnetics 29:160-2. 2008
    ..One example of problematic handling of PEMs is presented in detail, whereas other possible error sources and other aspects to be considered using such devices are outlined only briefly...
  78. ncbi Influence of body iron store status and cigarette smoking on cadmium body burden of healthy Thai women and men
    Soisungwan Satarug
    National Research Centre for Environmental Toxicology, University of Queensland, 39 Kessels Road, Coopers Plains Brisbane, QLD 4108, Australia
    Toxicol Lett 148:177-85. 2004
    The influence of cigarette smoking, body iron store status and gender on cadmium (Cd) body burden was examined in a group of 197 healthy Thais with overall mean age of 30.5 year (19-47 year)...
  79. ncbi Fish consumption and other environmental exposures and their associations with serum PCB concentrations among Mohawk women at Akwesasne
    Edward F Fitzgerald
    Bureau of Environmental and Occupational Epidemiology, New York State Department of Health, 547 River Street, Room 200, Troy, NY 12180 2216, USA
    Environ Res 94:160-70. 2004
    ..how dietary, occupational, and residential exposures to polychlorinated biphenyls (PCBs) contribute to body burden among pregnant Mohawk women residing near three hazardous waste sites...
  80. ncbi Arterial structure and function and environmental exposure to cadmium
    R Schutte
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    Occup Environ Med 65:412-9. 2008
    ..Few studies have addressed the effect of cadmium toxicity on arterial properties...
  81. pmc Computed tomography dose assessment for a 160 mm wide, 320 detector row, cone beam CT scanner
    J Geleijns
    Radiology Department, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Phys Med Biol 54:3141-59. 2009
    ..A CT dose descriptor that is based on an integration length smaller than the actual beam width is preferably expressed as an (average) dose, such as D100 for the 160 mm wide cone beam CT scanner, and not as CTDI100...
  82. ncbi Personal exposure to mobile phone frequencies and well-being in adults: a cross-sectional study based on dosimetry
    Silke Thomas
    Unit for Occupational and Environmental Epidemiology and Net Teaching, Institute and Outpatient Clinic for Occupational and Environmental Medicine, Ludwig Maximilians University Munich, Munich, Germany
    Bioelectromagnetics 29:463-70. 2008
    ..We did not find any statistically significant association between the exposure and chronic symptoms or between the exposure and acute symptoms. Larger studies using mobile phone dosimetry are warranted to confirm these findings...
  83. ncbi Characterization of personal RF electromagnetic field exposure and actual absorption for the general public
    W Joseph
    Department of Information Technology, Ghent University IBBT, Gaston Crommenlaan 8, B 9050 Ghent, Belgium
    Health Phys 95:317-30. 2008
    ..The methodology of this paper enables epidemiological studies to make an analysis in combination with both electric field and actual whole-body SAR values and to compare exposure with basic restrictions...
  84. ncbi Biomonitoring: is body burden relevant to public health?
    Dennis Paustenbach
    ChemRisk, Inc, 25 Jessie Street at Ecker Square, Suite 1800, San Francisco, CA 94105, USA
    Regul Toxicol Pharmacol 44:249-61. 2006
    ..We present suggestions for contextualizing biomonitoring results in order to provide the public with the tools to distinguish genuine health risks from trivial ones...
  85. pmc Biomonitoring of industrial pollutants: health and policy implications of the chemical body burden
    Joseph W Thornton
    The Earth Institute and Department of Biological Sciences, Columbia University, New York, NY, USA
    Public Health Rep 117:315-23. 2002
  86. ncbi Dioxins, dioxin-like PCBs and non-dioxin-like PCBs in foodstuffs: occurrence and dietary intake in The Netherlands
    A J Baars
    National Institute for Public Health and the Environment RIVM, P O Box 1, NL 3720 BA Bilthoven, The Netherlands
    Toxicol Lett 151:51-61. 2004
    ..Monitoring the dietary intake of PCBs is just as important as monitoring the intake of dioxins and dioxin-like PCBs, and attempts to decrease the exposure to both compound classes need continuous attention...
  87. ncbi Temporal trends in human TCDD body burden: decreases over three decades and implications for exposure levels
    Lesa L Aylward
    Exponent, Inc, Alexandria, Virginia 22314, USA
    J Expo Anal Environ Epidemiol 12:319-28. 2002
    ..Food sampling data are limited, but support these trends...
  88. ncbi Influence of z overscanning on normalized effective doses calculated for pediatric patients undergoing multidetector CT examinations
    Antonis Tzedakis
    Department of Medical Physics, Faculty of Medicine, University of Crete, P O Box 2208, Iraklion 71003, Crete, Greece
    Med Phys 34:1163-75. 2007
    ....
  89. ncbi Body burden of dioxins and dioxin-like polychlorinated biphenyls in pregnant women residing in a contaminated area
    Jein Wen Chen
    Division of Environmental Health and Occupational Medicine, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County 350, Taiwan
    Chemosphere 65:1667-77. 2006
    ..The present study was conducted to ascertain whether an increased body burden of dioxins existed in pregnant women living in an area of Tainan city contaminated by chemicals from this plant...
  90. ncbi Effects of adaptive section collimation on patient radiation dose in multisection spiral CT
    Paul D Deak
    Institute of Medical Physics and Department of Radiology, University Erlangen Nurnberg, Henkestrasse 91, 91052 Erlangen, Germany
    Radiology 252:140-7. 2009
    ..To evaluate the potential effectiveness of adaptive collimation in reducing computed tomographic (CT) radiation dose owing to z-overscanning by using dose measurements and Monte Carlo (MC) dose simulations...
  91. ncbi Overranging in multisection CT: quantification and relative contribution to dose--comparison of four 16-section CT scanners
    Aart J van der Molen
    Department of Radiology C 2S, Leiden University Medical Center, Albinusdreef 2, NL 2333 ZA Leiden, The Netherlands
    Radiology 242:208-16. 2007
    ..To quantify the number of overrange rotations and to assess their relative contribution to organ and effective doses at 16-section body computed tomography (CT)...
  92. ncbi Urinary cadmium and mortality among inhabitants of a cadmium-polluted area in Japan
    Hideaki Nakagawa
    Department of Public Health, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    Environ Res 100:323-9. 2006
    The influence of cadmium (Cd) body burden on mortality remains controversial...
  93. pmc Determinants of serum concentrations of organochlorine compounds in Swedish pregnant women: a cross-sectional study
    Anders Glynn
    Swedish National Food Administration, Uppsala, Sweden
    Environ Health 6:2. 2007
    ....
  94. ncbi Measurements of asbestos burden in tissues
    Ronald F Dodson
    ERI Consulting, Inc, 2026 Republic Drive, SteA, Tyler, TX 75701, USA
    Ann N Y Acad Sci 1076:281-91. 2006
    ..The present article will discuss the significance of findings of tissue burden based on both these variables...
  95. pmc Body burdens of polybrominated diphenyl ethers among urban anglers
    Kimberly B Morland
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Environ Health Perspect 113:1689-92. 2005
    ..These findings suggest that consumption of locally caught fish is not a major route of human exposure for this study population...
  96. ncbi Oral benzo[a]pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required for immune damage independent of total-body burden and clearance rate
    Shigeyuki Uno
    Department of Environmental Health, University of Cincinnati Medical Center, P O Box 670056, Cincinnati, OH 45267 0056, USA
    Mol Pharmacol 69:1103-14. 2006
    ..of immune damage in Cyp1a1-/- and Cyp1a1/1b1-/- mice is independent of plasma benzo[a]pyrene and total-body burden and clearance...
  97. ncbi Direct detector radiography versus dual reading computed radiography: feasibility of dose reduction in chest radiography
    Michael Gruber
    Department of Radiology and Ludwig Boltzmann Institute for Clinical and Experimental Radiologic Research, Medical University of Vienna, Waehringer Guertel 18 20, 1090, Vienna, Austria
    Eur Radiol 16:1544-50. 2006
    ..A further dose reduction does not appear to be feasible for DR without significant loss of image quality...
  98. pmc Conventional and CT angiography in children: dosimetry and dose comparisons
    Donald P Frush
    Division of Pediatric Radiology, Department of Radiology, Duke University Medical Center, 1905 McGovern Davison Children s Health Center, PO Box DUMC 3808, Durham 27710, NC, USA
    Pediatr Radiol 36:154-8. 2006
    ..It is with these dose data that assessment of risks, and ultimately the assessment of risk-benefit, can be better achieved...
  99. ncbi Exposure of Americans to polybrominated diphenyl ethers
    Matthew Lorber
    Office of Research and Development, United States Environmental Protection Agency, 1200 Pennsylvania Ave, NW, Washington, DC, USA
    J Expo Sci Environ Epidemiol 18:2-19. 2008
    ..These intakes were converted to a body burden using a simple pharmacokinetic (PK) model...
  100. ncbi Consumption of fatty fish from the Baltic Sea and PCB in whole venous blood, plasma and cord blood from delivering women in the Aland/Turku archipelago
    L Hagmar
    Department of Occupational and Environmental Medicine, University Hospital, Lund, Sweden
    J Toxicol Environ Health A 53:581-91. 1998
    The present study aimed to assess the role of fish consumption for the body burden of polychlorinated biphenyls (PCBs) in mothers living in the Aland and Turku archipelago in Finland...
  101. ncbi Level of polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls (PCDD/Fs, PCBs) in human milk and the input to infant body burden
    H R Chao
    Division of Environmental Health and Occupational Medicine, National Health Research Institute, Kaohsiung, Taiwan
    Food Chem Toxicol 42:1299-308. 2004
    ..and PCB levels in human milk, examined factors associated with levels of contamination, and assessed the infant body burden from breast-feeding...

Research Grants62

  1. Low level exposure to PBDEs: testing the hormetic and epigenetic hypotheses
    Lucio G Costa; Fiscal Year: 2013
    ..b>Body burden of PBDEs in humans in North America is much higher than in the rest of the world, and it is highest in infants (..
  2. Early Disease Biomarkers of PCB-exposed Human Population
    Sisir K Dutta; Fiscal Year: 2010
    ..Epidemiological studies will include the current body burden, and time-dependent changes in congener profiles in longitudinal studies in newborn babies using Slovak ..
  3. Detection of engineered nanomaterials in drinking water, food, commercial product
    Paul K Westerhoff; Fiscal Year: 2010
    ..In addition to validating the procedures, this work will establish the present body burden in humans of NMs (or lack thereof) and will help to define what levels of these materials are required in order ..
  4. Bisphenol A: Urine flow disorder and prostate pathology
    FREDERICK S contact VOM SAAL; Fiscal Year: 2010
    ..The 1st hypothesis is that BPA contributes to expression of OVD and prostate disease by increasing the body burden of estrogen during aging...
  5. Body Burden of PAHs and Cardiovascular Disease in the United States
    JOHN DAVIS CLARK; Fiscal Year: 2010
    ..Results of this proposed study can be used to influence policy decisions and resource allocation for the prevention of cardiovascular disease. ..
  6. Transgenerational epigenetic effects of PCBs on neuroendocrine systems
    Andrea C Gore; Fiscal Year: 2010
    ..proposal, PCBs are a persistent and continuing problem, as virtually all living humans have a detectable body burden of PCBs...
  7. Circadian Clock Disruption: A Mechanism for Dioxin-induced Metabolic Syndrome
    Shelley A Tischkau; Fiscal Year: 2013
    ..studies indicate increased incidence of insulin resistance and type 2 diabetes in humans with elevated body burden of certain lipophilic xenobiotics such as dioxins...
  8. Neu5Gc and anti-Neu5Gc antibodies for detection of cancer and cancer risk
    Ajit P Varki; Fiscal Year: 2011
    ..We therefore propose to study total body burden of NeuSGc, NeuSGc-containing glycans on secreted glyconjugates and specific anti-NeuSGc-antibodies-as ..
  9. DERMATOREMEDIATION OF IRON OVERLOAD
    Leonard M Milstone; Fiscal Year: 2010
    ..is that if epidermis can be made to act as a sink for internal iron, then epidermal shedding might reduce the body burden of iron. AIM I...
  10. Environmental & Genetic Risk Factors for Renal Function
    Virginia Weaver; Fiscal Year: 2009
    ..This application is a competing renewal application of the study "Exposure, dose, body burden, and health effects of lead" (Schwartz BS, PI) conducted from 1997-2001...
  11. Bioactivation of PBDEs by Human Cytochrome P-450
    James R Olson; Fiscal Year: 2013
    ..genetic variability in the CYP-specific metabolism of PBDEs contributes to interindividual variability in the body burden of PBDEs and the formation of toxic metabolites...
  12. Urinary cadmium and risk of breast cancer
    Jaymie R Meliker; Fiscal Year: 2013
    ..S., are necessary to assess whether a single spot urine sample is a stable, reproducible estimate of cadmium body burden. A second aim will develop molecular biomarkers to help identify biological endpoints of exposure and possible ..
  13. Mechanisms of Oxalobacter-Induced Enteric Oxalate Excretion
    Marguerite Hatch; Fiscal Year: 2010
    ..Understanding oxalate handling in PH1 and the potential roles and interactions of PAT1 and Oxalobacter in modulating the excessive body burden of oxalate in this genetic disease are now possible.
  14. Bio-monitoring Methylene Diphenyl Diisocyanate (MDI) exposure and body burden
    ADAM WISNEWSKI; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: This application will develop two new immunoassays to bio-monitor MDI exposure in the workplace, thus, ensuring adequate safety in polyurethane manufacture, and protecting the health of the US workforce. ..
  15. Prenatal exposure to a mixture of EDCs, maternal thyroid function and child neuro
    Megan K Horton; Fiscal Year: 2012
    ..The proposed study attempts to address these limitations by developing a composite index of body burden to EDCs and by applying brain imaging methods to elucidate changes in brain structure and function following ..
  16. PBDE Body Burdens, House Dust Concentrations and Associations with Thyroid Hormon
    Lyndsey Darrow; Fiscal Year: 2012
    ..Study findings will contribute to our understanding of the body burden, endocrine effects and exposure routes of brominated flame retardants in early childhood, and will help guide ..
  17. Bio-monitoring Methylene Diphenyl Diisocyanate (MDI) exposure and body burden
    ADAM WISNEWSKI; Fiscal Year: 2012
    ..this new phase II application for the project "Biomonitoring Methylene Diphenyl Diisocyanate (MDI) exposure and body burden", we aim to develop innovative biomonitoring approaches to exposure surveillance for MDI...
  18. Complementary and Alternative Medicine Detoxification: Safety and Efficacy
    Jason Allen; Fiscal Year: 2010
    ..Currently no conventional clinical practice guidelines address body burden reduction (detoxification) for disease treatment or prevention...
  19. Complementary and Alternative Medicine Detoxification: Safety and Efficacy
    Jason Allen; Fiscal Year: 2013
    ..Currently no conventional clinical practice guidelines address body burden reduction (detoxification) for disease treatment or prevention...
  20. Prenatal exposure to a mixture of EDCs, maternal thyroid function and child neuro
    Megan K Horton; Fiscal Year: 2013
    ..The proposed study attempts to address these limitations by developing a composite index of body burden to EDCs and by applying brain imaging methods to elucidate changes in brain structure and function following ..
  21. In Situ Sampling Tool for Assessing Bioavailability and Toxicity of Sediments
    Rolf U Halden; Fiscal Year: 2013
    ..be measured in fish using DNA microarray analysis to evaluate effects that may not be predicted solely based on body burden of parent compounds...
  22. Ancestral Exposures/Modern Responses to EDCs
    Andrea C Gore; Fiscal Year: 2013
    ..germ cells (transgenerational), together with exposures experienced during the individual's own lifetime (body burden) that cause molecular epigenetic changes to that individual...
  23. Trace Elements in Autopsy Tissues from World Trade Center Decedents
    Michael Marmor; Fiscal Year: 2013
    ..Etiologic studies of diseases observed among WTC survivors and medical treatments might be improved with better understanding of the body burden of WTC contaminants.
  24. Neuropsychological & Thyroid Effects of Perfluorinated Compounds in Older Adults
    Edward Fitzgerald; Fiscal Year: 2009
    ..By utilizing an existing surveillance cohort and building upon body burden and outcome data already collected, the proposed project is a more efficient way of contributing to the ..
  25. Serum Organochlorine Levels and Primary Liver Cancer: A Nested Case-Control Study
    Lawrence Engel; Fiscal Year: 2009
    ..To our knowledge, this study would be the first to examine liver cancer risk in relation to body burden of PCBs...
  26. EFFECTS OF LEAD ON THE IMMUNE SYSTEM OF CHILDREN
    Paula Lutz; Fiscal Year: 1990
    ..to identify nutritional deficiencies as well as possible sources of lead and to encourage efforts to reduce body burden. This group of children, together with appropriately matched controls identified during the same screening ..
  27. BEHAVIORAL TOXICITY OF LEAD--A PHARMACOLOGICAL ANALYSIS
    Deborah Cory Slechta; Fiscal Year: 2004
    DESCRIPTION: (Adapted from the Investigator's Abstract) Elevated lead (Pb) body burden still impacts almost 9% of U.S. children and >40% of children in some underdeveloped countries...
  28. CADMIUM TOXICOLOGY
    Curtis Klaassen; Fiscal Year: 2000
    ..Over half of the body burden of Cd is concentrated in liver and kidney and bound to metallothionein (MT)...
  29. HG METABOLIZING BACTERIA IN SUBJECTS WITH DENTAL AMALGAM
    Anne Summers; Fiscal Year: 1990
    ..and fecal microbial flora of his animal and human subjects and to correlate this phenomenon with amalgam mass, body burden of Hg, and excretion rate of Hg (as measured by Lorscheiders group)...
  30. EPIDEMIOLOGICAL RISK FACTORS FOR PARKINSONS DISEASE
    Jay Gorell; Fiscal Year: 2001
    ..Moreover, future research in chelation chemotherapy may then be considered as a means of reducing the body burden of lead...
  31. CENTRAL NERVOUS SYSTEM EFFECTS OF PCE EXPOSURE IN HUMANS
    Diana Echeverria; Fiscal Year: 1992
    ..A pre-exposure alveolar breath sample will be measured to control for variation in PCE body burden, supplementing 8-hour air monitoring for each exposed and 1:8 non-exposed worker...
  32. Advanced Reproductive Age and Environmental Health
    Stephanie Engel; Fiscal Year: 2007
    ..cytokine concentrations; the impact of genetic polymorphisms in key metabolizing enzymes on EA chemical body burden; and the association between EA chemical levels and biomarkers of oxidative stress...
  33. N-Acetylcysteine as a Biomonitoring Agent of Methylmercury Exposure
    DAVID AREMU; Fiscal Year: 2007
    ..of N-Acetylcysteine (NAC) challenge is optimally effective for monitoring various levels of MeHg exposure and body burden? (2) How do various routes of MeHg exposure influence the efficacy of the NAC challenge? (3) Is NAC challenge ..
  34. BIOMARKERS FOR TOTAL BODY BURDEN OF FLUORIDE
    Kirsten Lampi; Fiscal Year: 2004
    ..The fluoride content of bone appears to reflect total body burden of fluoride and is an appropriate "gold standard" for a fluoride biomarker...
  35. REACTIONS OF HEAVY METALS WITH EPITHELIAL CELLS
    ERNEST FOULKES; Fiscal Year: 1991
    ..In the non-industrial environment, the major source of the human body burden of heavy metals is ingestion through food and water; the problem with metal absorption resolves itself ..
  36. THE METABOLIC FATE OF MUTAGENIC AMINES IN ANIMALS & MAN
    DONALD DAVIES; Fiscal Year: 1991
    ..5. To assess the body burden of MeIQx and DiMeIQx in volunteers eating typical British and American diets. 6...
  37. CONTRIBUTION OF AMALGAM RESTORATION TO TOTAL BODY BURDEN
    Sybil Crawford; Fiscal Year: 2000
    ..objective of this project is to determine the contribution that dental amalgam restorations make to the total body burden of mercury in children...
  38. ENVIRONMENTAL AND GENETIC DETERMINANTS OF BREAST CANCER
    Mary Wolff; Fiscal Year: 1993
    Preliminary research conducted by our group has found a powerful association between female breast cancer and body burden of DDE, the principal metabolite of DDT...
  39. Cadmium Exposure and Breast Cancer Risk
    Jane McElroy; Fiscal Year: 2005
    ..The main hypothesis of interest is that higher body burden levels of Cd as measured in urine are associated with an increased risk of breast cancer...
  40. UTILITY OF BIOMARKERS AS EXOSURE AND DOSE MEASURES
    Elaine Symanski; Fiscal Year: 1999
    ..The proposed study will also investigate whether systematic changes in the underlying body burden distribution have taken place and, if so, account for such changes in the analyses...
  41. PCBs, CYP1A1 Polymorphism and Breast Cancer Risk in CT
    Tongzhang Zheng; Fiscal Year: 2002
    ..epidemiological studies suggest that women are at increased risk of breast cancer if they have an elevated body burden of PCBs and a CYP1A1 m2 genotype...
  42. ENVIRONMENTAL LEAD, REPRODUCTION, AND INFANT DEVELOPMENT
    Joseph Graziano; Fiscal Year: 1999
    ..We also propose to repeat the above analyses at ages 10-12 using K-XRF bone Pb, a more refined measure of body burden, to estimate associations. K-XRF bone Pb measurements will be conducted on site by Dr...
  43. PERI MENOPAUSAL MOBILIZATION OF LEAD FROM BONE
    Susan Muldoon; Fiscal Year: 1999
    ..Lead is accumulated in bone and as much as 95 percent of the body burden of lead is located within the skeleton...
  44. PCB Congener/Metabolite Patterns in Akwesasne Mohawks
    Anthony DeCaprio; Fiscal Year: 2006
    ..of research in this laboratory is to identify individual determinants of polychlorinated biphenyl (PCB) body burden, including those related to consumption of contaminated biota, in the Akwesasne Mohawks and in other exposed ..
  45. INNOVATIVE BIOMONITORING FOR LEAD IN SALIVA
    Charles Timchalk; Fiscal Year: 2006
    ..a salivary gland compartment that will be utilized to quantitatively predict blood Pb concentration and total body burden based on the amount of Pb detected in saliva specimens...
  46. TREATMENT OUTCOMES IN MODERATELY LEAD TOXIC CHILDREN
    John Rosen; Fiscal Year: 1993
    ..Our multidisciplinary approach focuses on the relationships between body burden of Pb and three types of outcomes...
  47. PEDIATRIC BODY LEAD BURDEN BY X-RAY FLUORESCENCE
    Robert Hart; Fiscal Year: 1993
    ..Yet, there is no tool available for measuring total pediatric body burden of lead...
  48. PEDIATRIC XRF BONE LEAD WITH AN X-RAY GENERATOR
    FREDRIC MILDER; Fiscal Year: 1991
    ..Adapted from applicant's abstract): X-ray fluorescence is an established technology for measuring the body burden of lead via the bone lead concentration...
  49. A GFP-based HTS Assay for HIV-1 Reactivating Agents
    Olaf Kutsch; Fiscal Year: 2007
    ..Remarkably, estimates of the total body burden of latently-infected cells are in the range of only 106, a notably small number that would seem to represent a ..
  50. Radiopharmaceutical Dosimetry Symposium
    Michael Stabin; Fiscal Year: 2002
    ..abstract_text> ..
  51. New Methods for Improved Image-based Dosimetry
    Michael Stabin; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  52. Non-Invasive Localization of Vulnerable Plaques
    Cynthia McCollough; Fiscal Year: 2009
    ....
  53. Realistic Phantom Series for OLINDA/EXM Version 2
    Michael Stabin; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  54. Virtual Patients for Computing Radiation Doses
    Xie Xu; Fiscal Year: 2007
    ..These two cores then support four parallel clinical projects. [unreadable] [unreadable] [unreadable]..
  55. 4D Visible Human Modeling for Radiation Dosimetry
    Xie George Xu; Fiscal Year: 2010
    ..4).To establish an internet-based information-sharing resource on virtual-human motion simulation and radiation dosimetry. ..
  56. Genetic Consequences of Therapies for Cancer
    John Boice; Fiscal Year: 2009
    ..abstract_text> ..
  57. Chemotherapy with injectable microdroplets
    FRANCESCO D ERRICO; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  58. High Stability Accelerator for Sub-Cellular Microbeam
    David Brenner; Fiscal Year: 2003
    ..We have considerably more demand for microbeam time than we can cope with, primarily because of limited physicist manpower. ..
  59. Measurement of pO2 in tissues in vivo and in vitro
    Harold Swartz; Fiscal Year: 2006
    ....
  60. Determination of Clinical Feasibility of EPR Oximetry of Tumors
    Harold Swartz; Fiscal Year: 2007
    ..Determining the feasibility of continuous measurements for up to 120 minutes. [unreadable] [unreadable] [unreadable]..