radiation dosage

Summary

Top Publications

  1. ncbi Computed tomography--an increasing source of radiation exposure
    David J Brenner
    Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA
    N Engl J Med 357:2277-84. 2007
  2. ncbi Adaptive statistical iterative reconstruction: assessment of image noise and image quality in coronary CT angiography
    Jonathon Leipsic
    Department of Radiology and Department of Medicine, Division of Cardiology, University of British Columbia, St Paul s Hospital, 1081 Burrard St, Vancouver, BC V6N 2N7, Canada
    AJR Am J Roentgenol 195:649-54. 2010
  3. ncbi Risk of cancer from diagnostic X-rays: estimates for the UK and 14 other countries
    Amy Berrington de Gonzalez
    Cancer Research UK Epidemiology Unit, University of Oxford, Radcliffe Infirmary, Oxford, UK
    Lancet 363:345-51. 2004
  4. ncbi Projected cancer risks from computed tomographic scans performed in the United States in 2007
    Amy Berrington de Gonzalez
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Arch Intern Med 169:2071-7. 2009
  5. ncbi Estimated radiation dose associated with cardiac CT angiography
    Jorg Hausleiter
    Department of Cardiology, Deutsches Herzzentrum Munchen, Klinik an der Technischen Universität München, Lazarettstrasse 36, 80636 München, Germany
    JAMA 301:500-7. 2009
  6. pmc Exposure to low-dose ionizing radiation from medical imaging procedures
    Reza Fazel
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30306, USA
    N Engl J Med 361:849-57. 2009
  7. pmc The effect of adaptive iterative dose reduction on image quality in 320-detector row CT coronary angiography
    F Tatsugami
    Department of Radiology, Osaka Medical College, Takatsuki City, Osaka, Japan
    Br J Radiol 85:e378-82. 2012
  8. pmc CT radiation dose optimization and estimation: an update for radiologists
    Hyun Woo Goo
    Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138 736, Korea
    Korean J Radiol 13:1-11. 2012
  9. ncbi OLINDA/EXM: the second-generation personal computer software for internal dose assessment in nuclear medicine
    Michael G Stabin
    Department of Radiology and Radiological Sciences, Vanderbilt University, 1161 21st Avenue S, Nashville, TN 37232 2675, USA
    J Nucl Med 46:1023-7. 2005
  10. ncbi Dose reduction in abdominal computed tomography: intraindividual comparison of image quality of full-dose standard and half-dose iterative reconstructions with dual-source computed tomography
    Matthias S May
    Department of Radiology, University of Erlangen, Erlangen, Germany
    Invest Radiol 46:465-70. 2011

Detail Information

Publications286 found, 100 shown here

  1. ncbi Computed tomography--an increasing source of radiation exposure
    David J Brenner
    Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA
    N Engl J Med 357:2277-84. 2007
  2. ncbi Adaptive statistical iterative reconstruction: assessment of image noise and image quality in coronary CT angiography
    Jonathon Leipsic
    Department of Radiology and Department of Medicine, Division of Cardiology, University of British Columbia, St Paul s Hospital, 1081 Burrard St, Vancouver, BC V6N 2N7, Canada
    AJR Am J Roentgenol 195:649-54. 2010
    ..The purpose of our study was to determine the effect of Adaptive Statistical Iterative Reconstruction (ASIR) on cardiac CT angiography (CTA) signal, noise, and image quality...
  3. ncbi Risk of cancer from diagnostic X-rays: estimates for the UK and 14 other countries
    Amy Berrington de Gonzalez
    Cancer Research UK Epidemiology Unit, University of Oxford, Radcliffe Infirmary, Oxford, UK
    Lancet 363:345-51. 2004
    ..Our aim was to estimate the extent of this risk on the basis of the annual number of diagnostic X-rays undertaken in the UK and in 14 other developed countries...
  4. ncbi Projected cancer risks from computed tomographic scans performed in the United States in 2007
    Amy Berrington de Gonzalez
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Arch Intern Med 169:2071-7. 2009
    ..Despite the great medical benefits, there is concern about the potential radiation-related cancer risk. We conducted detailed estimates of the future cancer risks from current CT scan use in the US according to age, sex, and scan type...
  5. ncbi Estimated radiation dose associated with cardiac CT angiography
    Jorg Hausleiter
    Department of Cardiology, Deutsches Herzzentrum Munchen, Klinik an der Technischen Universität München, Lazarettstrasse 36, 80636 München, Germany
    JAMA 301:500-7. 2009
    ..However, the potential risks due to exposure to ionizing radiation associated with CCTA have raised concerns...
  6. pmc Exposure to low-dose ionizing radiation from medical imaging procedures
    Reza Fazel
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30306, USA
    N Engl J Med 361:849-57. 2009
    ..The growing use of imaging procedures in the United States has raised concerns about exposure to low-dose ionizing radiation in the general population...
  7. pmc The effect of adaptive iterative dose reduction on image quality in 320-detector row CT coronary angiography
    F Tatsugami
    Department of Radiology, Osaka Medical College, Takatsuki City, Osaka, Japan
    Br J Radiol 85:e378-82. 2012
    ..To evaluate the effect of adaptive iterative dose reduction (AIDR) on image noise and image quality as compared with standard filtered back projection (FBP) in 320-detector row CT coronary angiography (CTCA)...
  8. pmc CT radiation dose optimization and estimation: an update for radiologists
    Hyun Woo Goo
    Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138 736, Korea
    Korean J Radiol 13:1-11. 2012
    ..This review article will provide an update on how we can optimize CT dose in order to maximize the benefit-to-risk ratio of this clinically useful diagnostic imaging method...
  9. ncbi OLINDA/EXM: the second-generation personal computer software for internal dose assessment in nuclear medicine
    Michael G Stabin
    Department of Radiology and Radiological Sciences, Vanderbilt University, 1161 21st Avenue S, Nashville, TN 37232 2675, USA
    J Nucl Med 46:1023-7. 2005
    ..The OLINDA/EXM version 1.0 personal computer code was created as a replacement for the widely used MIRDOSE3.1 code. This paper documents the basic function of the code and how it is similar to and different from the MIRDOSE software...
  10. ncbi Dose reduction in abdominal computed tomography: intraindividual comparison of image quality of full-dose standard and half-dose iterative reconstructions with dual-source computed tomography
    Matthias S May
    Department of Radiology, University of Erlangen, Erlangen, Germany
    Invest Radiol 46:465-70. 2011
    ..We sought to evaluate the image quality of iterative reconstruction in image space (IRIS) in half-dose (HD) datasets compared with full-dose (FD) and HD filtered back projection (FBP) reconstruction in abdominal computed tomography (CT)...
  11. pmc Cancer risks attributable to low doses of ionizing radiation: assessing what we really know
    David J Brenner
    Center for Radiological Research, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 100:13761-6. 2003
    ..This linearity assumption is not necessarily the most conservative approach, and it is likely that it will result in an underestimate of some radiation-induced cancer risks and an overestimate of others...
  12. ncbi Radiation dose associated with common computed tomography examinations and the associated lifetime attributable risk of cancer
    Rebecca Smith-Bindman
    Department of Radiology, University of California, San Francisco, 94115, USA
    Arch Intern Med 169:2078-86. 2009
    ..We sought to estimate the radiation dose associated with common CT studies in clinical practice and quantify the potential cancer risk associated with these examinations...
  13. ncbi Multisection CT protocols: sex- and age-specific conversion factors used to determine effective dose from dose-length product
    Paul D Deak
    Institute of Medical Physics, University Erlangen Nurnberg, Henkestr 91, Erlangen, Germany
    Radiology 257:158-66. 2010
    ....
  14. ncbi Computed tomography and radiation risks: what pediatric health care providers should know
    Donald P Frush
    Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Pediatrics 112:951-7. 2003
    ..For this reason, this article will summarize the issues with CT patterns of use and radiation risk, and provide dose reduction strategies pertinent to pediatric health care providers...
  15. ncbi Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group
    Jamie K Waselenko
    Walter Reed Army Medical Center and Catholic University of America, Washington, DC 20307, USA
    Ann Intern Med 140:1037-51. 2004
    ..For terrorist or accidental events involving exposure to radioiodines, prophylaxis against malignant disease of the thyroid is also recommended, particularly for children and adolescents...
  16. ncbi Adaptive statistical iterative reconstruction versus filtered back projection in the same patient: 64 channel liver CT image quality and patient radiation dose
    Lee M Mitsumori
    Department of Radiology, University of Washington School of Medicine, 1959 NE Pacific Street, Box 357115, Seattle, WA 98195, USA
    Eur Radiol 22:138-43. 2012
    ..To compare routine dose liver CT reconstructed with filtered back projection (FBP) versus low dose images reconstructed with FBP and adaptive statistical iterative reconstruction (ASIR)...
  17. ncbi Estimated radiation dose reduction using adaptive statistical iterative reconstruction in coronary CT angiography: the ERASIR study
    Jonathon Leipsic
    Department of Radiology and Department of Medicine, Division of Cardiology, University of British Columbia, Vancouver, BC, Canada
    AJR Am J Roentgenol 195:655-60. 2010
    ..The objective of our study was to assess the impact of Adaptive Statistical Iterative Reconstruction (ASIR) on radiation dose and study quality for coronary CT angiography (CTA)...
  18. ncbi Chest computed tomography using iterative reconstruction vs filtered back projection (Part 2): image quality of low-dose CT examinations in 80 patients
    Francois Pontana
    Department of Thoracic Imaging, Hospital Calmette EA 2694, University Lille Nord de France, F 59000, Lille, France
    Eur Radiol 21:636-43. 2011
    ..To evaluate the image quality of an iterative reconstruction algorithm (IRIS) in low-dose chest CT in comparison with standard-dose filtered back projection (FBP) CT...
  19. ncbi Innovations in CT dose reduction strategy: application of the adaptive statistical iterative reconstruction algorithm
    Alvin C Silva
    Department of Radiology, Mayo Clinic Arizona, 13400 E Shea Blvd, Scottsdale, AZ 85259, USA
    AJR Am J Roentgenol 194:191-9. 2010
    ....
  20. ncbi Aorto-iliac multidetector-row CT angiography with low kV settings: improved vessel enhancement and simultaneous reduction of radiation dose
    B Wintersperger
    Department of Clinical Radiology, University of Munich, Marchioninistrasse 15, 81377, Munich, Germany
    Eur Radiol 15:334-41. 2005
    ..7+/-0.4 vs 10.1+/-1.2 mSv; P<0.0001). Tube kVp reduction from 120 to 100 kVp allows for significant reduction of patient dose in abdominal CT angiography, without significant change in SNR,CNR and image quality...
  21. ncbi Raw data-based iterative reconstruction in body CTA: evaluation of radiation dose saving potential
    Anna Winklehner
    Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Raemistrasse 100, CH 8091 Zurich, Switzerland
    Eur Radiol 21:2521-6. 2011
    ..To evaluate prospectively, in patients undergoing body CTA, the radiation dose saving potential of raw data-based iterative reconstruction as compared to filtered back projection (FBP)...
  22. ncbi Iterative reconstruction in image space (IRIS) in cardiac computed tomography: initial experience
    Marcio Sommer Bittencourt
    Internal Medicine Division, University Hospital, University of Sao Paulo Medical School, Av Lineu Prestes, 2565, Butanta, Sao Paulo, 05508 000, Brazil
    Int J Cardiovasc Imaging 27:1081-7. 2011
    ..1 HU) and higher signal to noise and image to noise ratios in the proximal coronary arteries. IRIS reduces image noise and contrast-to-noise ratio in coronary CT angiography, thus providing potential for reducing radiation exposure...
  23. pmc Radiation dose reduction of chest CT with iterative reconstruction in image space - Part I: studies on image quality using dual source CT
    Hye Jeon Hwang
    Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138 736, Korea
    Korean J Radiol 13:711-9. 2012
    ..To determine whether the image quality (IQ) is improved with iterative reconstruction in image space (IRIS), and whether IRIS can be used for radiation reduction in chest CT...
  24. pmc SCCT guidelines on radiation dose and dose-optimization strategies in cardiovascular CT
    Sandra S Halliburton
    Imaging Institute, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Avenue, J1 4, Cleveland, OH 44195, USA
    J Cardiovasc Comput Tomogr 5:198-224. 2011
    ....
  25. ncbi CT angiography of pulmonary arteries to detect pulmonary embolism: improvement of vascular enhancement with low kilovoltage settings
    Claudia Schueller-Weidekamm
    Department of Radiology, University Hospital of Vienna, Vienna, Austria
    Radiology 241:899-907. 2006
    ....
  26. ncbi Effective doses in radiology and diagnostic nuclear medicine: a catalog
    Fred A Mettler
    Department of Radiology and Nuclear Medicine, New Mexico Veterans Administration Healthcare System, 1501 San Pedro Blvd, Albuquerque, NM 87108, USA
    Radiology 248:254-63. 2008
    ..Average effective dose for most nuclear medicine procedures varies between 0.3 and 20 mSv. These doses can be compared with the average annual effective dose from background radiation of about 3 mSv...
  27. ncbi Repair of DNA damage induced by accelerated heavy ions in mammalian cells proficient and deficient in the non-homologous end-joining pathway
    Ryuichi Okayasu
    International Space Radiation Laboratory, National Institute of Radiological Sciences, Inage Ku, Chiba shi 263 8555, Japan
    Radiat Res 165:59-67. 2006
    ..This delay was further emphasized in NHEJ-defective 180BR cells. Our results indicate that high-LET radiation induces complex DNA damage that is not easily repaired or is not repaired by NHEJ even at low radiation doses such as 2 Gy...
  28. ncbi Automatic selection of tube potential for radiation dose reduction in CT: a general strategy
    Lifeng Yu
    Department of Radiology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Med Phys 37:234-43. 2010
    ..The purpose of this work was to develop a general strategy that allows for automatic tube potential selection for each individual patient and each diagnostic task...
  29. pmc Strategies for reducing radiation dose in CT
    Cynthia H McCollough
    Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Radiol Clin North Am 47:27-40. 2009
    ..To satisfy the ALARA principle, the dose reduction strategies described in this article must be well understood and properly used. The use of CT must also be justified for the specific diagnostic task...
  30. ncbi Radiologic and nuclear medicine studies in the United States and worldwide: frequency, radiation dose, and comparison with other radiation sources--1950-2007
    Fred A Mettler
    Radiology and Nuclear Medicine Service, New Mexico VA Health Care System, 1501 San Pedro Blvd SE, Albuquerque, NM 87108, USA
    Radiology 253:520-31. 2009
    ..Worldwide, the average annual per-capita effective dose from medicine (about 0.6 mSv of the total 3.0 mSv received from all sources) has approximately doubled in the past 10-15 years...
  31. ncbi Feasibility of low-dose coronary CT angiography: first experience with prospective ECG-gating
    Lars Husmann
    Department of Medical Radiology and Cardiovascular Center, University Hospital Zurich, Raemistr 100, CH 8091 Zurich, Switzerland
    Eur Heart J 29:191-7. 2008
    ..To determine the feasibility of prospective electrocardiogram (ECG)-gating to achieve low-dose computed tomography coronary angiography (CTCA)...
  32. ncbi Noncancer disease incidence in atomic bomb survivors, 1958-1998
    Michiko Yamada
    Department of Clinical Studies, Radiation Effects Research Foundation, Hiroshima, Japan
    Radiat Res 161:622-32. 2004
    ..These results attest to the need for continued follow-up of the aging A-bomb survivors to fully elucidate the effects of radiation exposure on the occurrence of noncancer diseases...
  33. ncbi Learning and activity after irradiation of the young mouse brain analyzed in adulthood using unbiased monitoring in a home cage environment
    Niklas Karlsson
    Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, SE 405 30, Sweden
    Radiat Res 175:336-46. 2011
    ....
  34. ncbi Measurements of energetic particle radiation in transit to Mars on the Mars Science Laboratory
    C Zeitlin
    Southwest Research Institute, Boulder, CO, USA
    Science 340:1080-4. 2013
    ..The dose equivalent for even the shortest round-trip with current propulsion systems and comparable shielding is found to be 0.66 ± 0.12 sievert...
  35. ncbi The 15-Country Collaborative Study of Cancer Risk among Radiation Workers in the Nuclear Industry: estimates of radiation-related cancer risks
    E Cardis
    International Agency for Research on Cancer, Lyon, France
    Radiat Res 167:396-416. 2007
    ..Further studies will be important to better assess the role of tobacco and other occupational exposures in our risk estimates...
  36. pmc Radiation dose reduction of chest CT with iterative reconstruction in image space - Part II: assessment of radiologists' preferences using dual source CT
    Hye Jeon Hwang
    Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138 736, Korea
    Korean J Radiol 13:720-7. 2012
    ..To evaluate the impact of radiation dose and reconstruction algorithms on radiologists' preferences, and whether an iterative reconstruction in image space (IRIS) can be used for dose reduction in chest CT...
  37. ncbi Comparison of hybrid and pure iterative reconstruction techniques with conventional filtered back projection: dose reduction potential in the abdomen
    Sarabjeet Singh
    Massachusetts General Hospital Imaging, Massachusetts General Hospital, Boston, MA 02114, USA
    J Comput Assist Tomogr 36:347-53. 2012
    ....
  38. ncbi Radiation dose reduction with Sinogram Affirmed Iterative Reconstruction technique for abdominal computed tomography
    Mannudeep K Kalra
    Department of Radiology, Massachusetts General Hospital, Boston, MA, USA
    J Comput Assist Tomogr 36:339-46. 2012
    ....
  39. ncbi Radiocesium contaminations of 20 wood species and the corresponding gamma-ray dose rates around the canopies at 5 months after the Fukushima nuclear power plant accident
    Toshihiro Yoshihara
    Plant Molecular Biology, Laboratory of Environmental Science, Central Research Institute of Electric Power Industry CRIEPI, 1646 Abiko, Chiba 270 1194, Japan
    J Environ Radioact 115:60-8. 2013
    ..This may be due to differences in the balance between the attenuation resulting from a shielding effect of the plant bodies and the higher radiocesium accumulation in the leaves...
  40. ncbi A generalized linear-quadratic model incorporating reciprocal time pattern of radiation damage repair
    Zhibin Huang
    Department of Radiation Oncology, East Carolina University, Greenville, North Carolina 27834, USA
    Med Phys 39:224-30. 2012
    ..As a result, the purpose of this study was to investigate a new generalized linear-quadratic (LQ) model incorporating a repair pattern with reciprocal time. The new formulas were tested with published experimental data...
  41. pmc Radiation exposure and circulatory disease risk: Hiroshima and Nagasaki atomic bomb survivor data, 1950-2003
    Yukiko Shimizu
    Department of Epidemiology, Radiation Effects Research Foundation, 5 2 Hijiyama Park, Minami Ku, Hiroshima 732 0815, Japan
    BMJ 340:b5349. 2010
    ..To investigate the degree to which ionising radiation confers risk of mortality from heart disease and stroke...
  42. ncbi CT dose reduction and dose management tools: overview of available options
    Cynthia H McCollough
    Department of Radiology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Radiographics 26:503-12. 2006
    ..Modulation both angularly around the patient and along the z-axis is optimal, but the tube current must be appropriately adapted to patient size for diagnostic image quality to be achieved...
  43. ncbi The disaster at Japan's Fukushima-Daiichi nuclear power plant after the March 11, 2011 earthquake and tsunami, and the resulting spread of radioisotope contamination
    Takeo Ohnishi
    Department of Radiation Oncology, School of Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
    Radiat Res 177:1-14. 2012
    ....
  44. pmc Strategies for optimizing the response of cancer and normal tissues to radiation
    Everett J Moding
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham 27710, North Carolina, USA
    Nat Rev Drug Discov 12:526-42. 2013
    ..Here, we review efforts to develop approaches that could improve outcomes with radiation therapy by increasing the probability of tumour cure or by decreasing normal tissue toxicity. ..
  45. ncbi Short-term exposure to a 1439-MHz TDMA signal exerts no estrogenic effect in rats
    Hiroharu Yamashita
    Department of Surgical Oncology, The University of Tokyo, Graduate School of Medicine, Tokyo, Japan
    Bioelectromagnetics 31:573-5. 2010
    ....
  46. pmc Effects of proton radiation dose, dose rate and dose fractionation on hematopoietic cells in mice
    J H Ware
    Department of Radiation Oncology, Division of Oncology Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6072, USA
    Radiat Res 174:325-30. 2010
    ....
  47. ncbi Pulmonary mycobacterial disease: diagnostic performance of low-dose digital tomosynthesis as compared with chest radiography
    Eun Young Kim
    Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Radiology 257:269-77. 2010
    ..To compare the diagnostic performance of a low-radiation-dose digital tomosynthesis (DTS) technique with that of conventional radiography in the detection of lung lesions in patients with pulmonary mycobacterial disease...
  48. pmc Converting dose-length product to effective dose at CT
    Walter Huda
    Department of Radiology, Medical University of South Carolina, PO Box 250322, 169 Ashley Ave, Charleston, SC 29425, USA
    Radiology 248:995-1003. 2008
    ..To determine effective dose (ED) per unit dose-length product (DLP) conversion factors for computed tomographic (CT) dosimetry...
  49. ncbi Dosimetric analysis of 177Lu-cG250 radioimmunotherapy in renal cell carcinoma patients: correlation with myelotoxicity and pretherapeutic absorbed dose predictions based on 111In-cG250 imaging
    Alexander B Stillebroer
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Nucl Med 53:82-9. 2012
    ..The estimated radiation doses were correlated with observed hematologic toxicity. In addition, the accuracy of the predicted therapeutic absorbed doses, based on diagnostic (111)In-cG250 data, were determined...
  50. ncbi Retrospective gating vs. prospective triggering for noninvasive coronary angiography: Assessment of image quality and radiation dose using a 256-slice CT scanner with 270 ms gantry rotation
    Wei Yip Law
    Department of Radiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan, ROC
    Acad Radiol 18:31-9. 2011
    ....
  51. ncbi Low kilovoltage cardiac dual-source CT: attenuation, noise, and radiation dose
    Sebastian Leschka
    Institute of Radiology, Kantonsspital St Gallen, St Gallen, Switzerland
    Eur Radiol 18:1809-17. 2008
    ..4 +/- 0.6 mSv, P < 0.001) protocols. Dual-source CTCA with 100 kV is feasible in patients of normal weight, results in a diagnostic image quality with a higher CNR, and at the same time significantly reduces the radiation dose...
  52. ncbi Abdominal CT: comparison of low-dose CT with adaptive statistical iterative reconstruction and routine-dose CT with filtered back projection in 53 patients
    Yoshiko Sagara
    Department of Radiology, Oita University Faculty of Medicine, Idaigaoka Hasama machi, Yufu Shi, Oita, Japan
    AJR Am J Roentgenol 195:713-9. 2010
    ....
  53. ncbi Megakaryocytopoiesis and thrombopoiesis in hematopoietic stem cells exposed to ionizing radiation
    Satoru Monzen
    Department of Radiological Life Sciences, Hirosaki University Graduate School of Health Sciences, 66 1 Hon cho, Hirosaki, Aomori 036 8564, Japan
    Radiat Res 176:716-24. 2011
    ..Ionizing radiation may have the potential to promote both megakaryocytopoiesis and thrombopoiesis...
  54. pmc Effect of low doses of ionising radiation in infancy on cognitive function in adulthood: Swedish population based cohort study
    Per Hall
    Department of Medical Epidemiology and Biostatistics, Karolinska Institute, PO Box 281, SE 171 77 Stockholm, Sweden
    BMJ 328:19. 2004
    ..To determine whether exposure to low doses of ionising radiation in infancy affects cognitive function in adulthood...
  55. pmc The National Lung Screening Trial: overview and study design
    Denise R Aberle
    Center for Statistical Sciences, Brown University, Box G S121, 121 S Main St, 7th Floor, Providence, RI 02912, USA
    Radiology 258:243-53. 2011
    ..The NLST is such a trial. The rationale for and design of the NLST are presented...
  56. ncbi Evaluation of geometric changes of parotid glands during head and neck cancer radiotherapy using daily MVCT and automatic deformable registration
    Choonik Lee
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Radiother Oncol 89:81-8. 2008
    ..To assess and evaluate geometrical changes in parotid glands using deformable image registration and megavoltage CT (MVCT) images...
  57. ncbi Low doses of very low-dose-rate low-LET radiation suppress radiation-induced neoplastic transformation in vitro and induce an adaptive response
    E Elmore
    Department of Radiation Oncology and Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, California 92697, USA
    Radiat Res 169:311-8. 2008
    ..When the dose rate drops below approximately 1 mGy/day, this suppression is apparently lost, suggesting a possible dose-rate-dependent threshold for this process...
  58. pmc The time variation of dose rate artificially increased by the Fukushima nuclear crisis
    Masahiro Hosoda
    Hirosaki University, Graduate School of Health Sciences, 66 1 Hon cho, Hirosaki, Aomori 036 8564, Japan
    Sci Rep 1:87. 2011
    ..g. Fukushima, Koriyama and Nihonmatsu Cities) was 68 mSv. The evacuation is justified from the viewpoint of radiation protection...
  59. ncbi Terahertz radiation increases genomic instability in human lymphocytes
    Avital Korenstein-Ilan
    Department of Physiology and Pharmacology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Radiat Res 170:224-34. 2008
    ..Our results demonstrate that exposure of lymphocytes in vitro to a low power density of 0.1 THz radiation induces genomic instability. These findings, if verified, may suggest that such exposure may result in an increased risk of cancer...
  60. ncbi Circle of Willis at CT angiography: dose reduction and image quality--reducing tube voltage and increasing tube current settings
    Annet Waaijer
    Department of Radiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Radiology 242:832-9. 2007
    ..To prospectively assess the effects of lower tube voltage and various effective tube currents on image quality for computed tomographic (CT) angiography of the circle of Willis...
  61. ncbi Radiation-induced adaptive responses and bystander effects
    Hideki Matsumoto
    Department of Experimental Radiology and Health Physics, Faculty of Medical Science, University of Fukui, Matsuoka, Fukui, Japan
    Biol Sci Space 18:247-54. 2004
    ..This review focuses on the radiation-induced bystander effect and the adaptive response, provides a description of the two phenomena, and discusses the contribution of the former to the latter...
  62. ncbi Low-dose prospective ECG-triggering dual-source CT angiography in infants and children with complex congenital heart disease: first experience
    Zhaoping Cheng
    Shandong Medical Imaging Research Institute, Shandong University, No 324, Jingwu Road, Jinan, Shandong, 250021, China
    Eur Radiol 20:2503-11. 2010
    ..To explore the clinical value of low-dose prospective ECG-triggering dual-source CT (DSCT) angiography in infants and children with complex congenital heart disease (CHD) compared with transthoracic echocardiography (TTE)...
  63. ncbi Informatics in radiology: sliding-thin-slab averaging for improved depiction of low-contrast lesions with radiation dose savings at thin-section CT
    Christian von Falck
    Department of Radiology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Radiographics 30:317-26. 2010
    ..Supplemental material available at http://radiographics.rsna.org/lookup/suppl/doi:10.1148/rg.302096007/-/DC1...
  64. ncbi PCC-ring induction in human lymphocytes exposed to gamma and neutron irradiation
    Ana I Lamadrid
    Centro de Protección e Higiene de las Radiaciones, La Habana, Cuba
    J Radiat Res (Tokyo) 48:1-6. 2007
    ..In conclusion, with this technique it is possible to set up dose effect curves up to 25 or 10 Gy according to the gamma or neutron radiation...
  65. pmc Dual-source dual-energy CT with additional tin filtration: Dose and image quality evaluation in phantoms and in vivo
    Andrew N Primak
    Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
    AJR Am J Roentgenol 195:1164-74. 2010
    ..The objective of this study was to investigate the effect on radiation dose and image quality of the use of additional spectral filtration for dual-energy CT using dual-source CT (DSCT)...
  66. ncbi Improving low-dose abdominal CT images by Weighted Intensity Averaging over Large-scale Neighborhoods
    Yang Chen
    The Laboratory of Image Science and Technology, Southeast University, China
    Eur J Radiol 80:e42-9. 2011
    ..The purpose of this paper is to improve the abdominal LDCT images by the approach of Weighted Intensity Averaging over Large-scale Neighborhoods (WIA-LN)...
  67. ncbi Biomarkers for human radiation exposure
    M Ahmad Chaudhry
    Department of Medical Laboratory and Radiation Sciences, College of Nursing and Health Sciences, University of Vermont, 302 Rowell Building, Burlington, VT 05405, USA
    J Biomed Sci 15:557-63. 2008
    ..Microarray based studies are identifying new radiation responsive genes that could potentially be used as biomarkers of human exposure to radiation after an accident...
  68. ncbi CT with a computer-simulated dose reduction technique for detection of pediatric nephroureterolithiasis: comparison of standard and reduced radiation doses
    Boaz Karmazyn
    Department of Pediatric Radiology, Indiana University School of Medicine, Riley Hospital for Children, 702 Barnhill Dr, Rm 1053, Indianapolis, IN 46202, USA
    AJR Am J Roentgenol 192:143-9. 2009
    ..The purpose of this study was to compare the diagnostic capabilities of standard- and reduced-dose CT in the detection of nephroureterolithiasis in children...
  69. pmc Analysis of gene expression in normal and cancer cells exposed to gamma-radiation
    M Ahmad Chaudhry
    Department of Medical Laboratory and Radiation Sciences, University of Vermont, 302 Rowell Building, Burlington, 05405 VT, USA
    J Biomed Biotechnol 2008:541678. 2008
    ..These results indicate cell specific modulation of gene expression and suggest the involvement of different pathways in cellular response to radiation treatment in different cells...
  70. ncbi Image quality and radiation exposure at pulmonary CT angiography with 100- or 120-kVp protocol: prospective randomized study
    Christoph M Heyer
    Institute of Diagnostic Radiology, Interventional Radiology and Nuclear Medicine, BG Clinics Bergmannsheil, Ruhr University of Bochum, Buerkle de la Camp Platz 1, D 44789, Bochum, Germany
    Radiology 245:577-83. 2007
    ..To prospectively compare 16-section multidetector computed tomography (CT) at 100 and 120 kVp for image quality and radiation dose...
  71. ncbi Low-dose binary behavior of bystander cell killing after microbeam irradiation of a single cell with focused c(k) x rays
    Giuseppe Schettino
    Gray Cancer Institute, Mount Vernon Hospital, Northwood, Middlesex, United Kingdom
    Radiat Res 163:332-6. 2005
    ..3% that the cell will emit the bystander signal. The data presented in this paper have also been analyzed statistically to test the possibility that complex DNA double-strand breaks may be the initial critical event...
  72. ncbi X-ray dose training: are we exposed to enough?
    K Jacob
    Department of Medicine, Derriford Hospital, Plymouth, UK
    Clin Radiol 59:928-34; discussion 926-7. 2004
    ..To study knowledge of radiation exposure among doctors of various grades and specialties in a large district general hospital...
  73. ncbi Radiation dose reduction and coronary assessability of prospective electrocardiogram-gated computed tomography coronary angiography: comparison with retrospective electrocardiogram-gated helical scan
    Takao Maruyama
    Department of Cardiology, Kawasaki Hospital, Kobe, Japan
    J Am Coll Cardiol 52:1450-5. 2008
    ....
  74. ncbi Radiation exposure to the surgeon during fluoroscopically assisted percutaneous vertebroplasty: a prospective study
    Roger Harstall
    Department of Orthopaedic Surgery, Inselspital, University of Berne, Switzerland
    Spine (Phila Pa 1976) 30:1893-8. 2005
    ..A prospective case control study design was conducted...
  75. pmc Radiation exposure to premature infants in a neonatal intensive care unit in Turkey
    Turan Olgar
    Ankara University, Institute of Nuclear Science, Tandogan, Ankara, Turkey
    Korean J Radiol 9:416-9. 2008
    ..The aim of this work was to determine the radiation dose received by infants from radiographic exposure and the contribution from scatter radiation due to radiographic exposure of other infants in the same room...
  76. ncbi [Awareness of radiation exposure of thoracic CT scans and conventional radiographs: what do non-radiologists know?]
    C M Heyer
    Institut für Diagnostische Radiologie, Interventionelle Radiologie und Nuklearmedizin, BG Kliniken Bergmannsheil, Ruhr Universitat Bochum
    Rofo 179:261-7. 2007
    ..Assessment of the knowledge of non-radiological physicians concerning radiation exposure during radiological procedures on the thorax...
  77. ncbi Hypervascular liver tumors: low tube voltage, high tube current multi-detector row CT for enhanced detection--phantom study
    Sebastian T Schindera
    Department of Radiology, Duke University Medical Center, Box 3808, Erwin Rd, Durham, NC 27710, USA
    Radiology 246:125-32. 2008
    ....
  78. ncbi Major radiation exposure--what to expect and how to respond
    Fred A Mettler
    Department of Radiology, University of New Mexico Health Sciences Center, Albuquerque 87131, USA
    N Engl J Med 346:1554-61. 2002
  79. ncbi Peer assessment of pediatric surgeons for potential risks of radiation exposure from computed tomography scans
    Henry E Rice
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    J Pediatr Surg 42:1157-64. 2007
    ..Radiology literature reports potential cancer risk from radiation exposure from computed tomography (CT). We hypothesized that pediatric surgeons' knowledge of potential risks of radiation exposure from CT scan is limited...
  80. ncbi Contribution of indirect action to radiation-induced mammalian cell inactivation: dependence on photon energy and heavy-ion LET
    Atsushi Ito
    Course of Energy Engineering, Department of Applied Science, School of Engineering, Tokai University, Hiratsuka shi, Kanagawa 259 1292, Japan
    Radiat Res 165:703-12. 2006
    ..A significant contribution of direct action was also found for the increased RBE in the low photon energy region...
  81. ncbi Estimating cancer risks from pediatric CT: going from the qualitative to the quantitative
    David J Brenner
    Center for Radiological Research, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Pediatr Radiol 32:228-3; discussion 242-4. 2002
  82. ncbi Genome-wide gene expression changes in normal human fibroblasts in response to low-LET gamma-radiation and high-LET-like 125IUdR exposures
    M Sokolov
    Department of Nuclear Medicine, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892 1180, USA
    Radiat Prot Dosimetry 122:195-201. 2006
    ....
  83. ncbi Radiation exposure during fluoroscopically assisted pedicle screw insertion in the lumbar spine
    D P Jones
    Christchurch Hospital, New Zealand
    Spine (Phila Pa 1976) 25:1538-41. 2000
    ..CONCLUSIONS: The source-superior position is the preferred position for pedicle screw screening if a working space is required. Patient exposure is minimized, and surgeon dose is well within current recommendations...
  84. ncbi Detection and characterization of lesions on low-radiation-dose abdominal CT images postprocessed with noise reduction filters
    Mannudeep K Kalra
    Division of Abdominal Imaging and Intervention, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, White 270E, Boston, MA 02114, USA
    Radiology 232:791-7. 2004
    ..To assess the effect of noise reduction filters on detection and characterization of lesions on low-radiation-dose abdominal computed tomographic (CT) images...
  85. ncbi Radiation dose reduction with chest computed tomography using adaptive statistical iterative reconstruction technique: initial experience
    Priyanka Prakash
    Division of Thoracic Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Comput Assist Tomogr 34:40-5. 2010
    ..To assess radiation dose reduction and image quality for weight-based chest computed tomographic (CT) examination results reconstructed using adaptive statistical iterative reconstruction (ASIR) technique...
  86. ncbi Neuropathology of ablation of rat gliosarcomas and contiguous brain tissues using a microplanar beam of synchrotron-wiggler-generated X rays
    J A Laissue
    Institute of Pathology, University of Bern, Switzerland
    Int J Cancer 78:654-60. 1998
    ..Correlation of those grades with radiation doses shows that loss of tissue structure was confined to beam-crossing regions and that only minor damage was done to zones of the brain irradiated unidirectionally...
  87. pmc Method for automatic tube current selection for obtaining a consistent image quality and dose optimization in a cardiac multidetector CT
    Weiwei Qi
    Department of Radiology, Peking University People s Hospital, Beijing, China
    Korean J Radiol 10:568-74. 2009
    ..To evaluate a quantitative method for individually adjusting the tube current to obtain images with consistent noise in electrocardiogram (ECG)-gated CT cardiac scans...
  88. ncbi A comparison of (111)In-DOTATOC and (111)In-DOTATATE: biodistribution and dosimetry in the same patients with metastatic neuroendocrine tumours
    F Forrer
    Institute of Nuclear Medicine, University Hospital, Petersgraben 4, 4031, Basel, Switzerland
    Eur J Nucl Med Mol Imaging 31:1257-62. 2004
    ....
  89. ncbi Suppression of thymic lymphoma induction by life-long low-dose-rate irradiation accompanied by immune activation in C57BL/6 mice
    Yasuhiro Ina
    Low Dose Radiation Research Center, Central Research Institute of Electric Power Industry, 2 11 1 Iwado Kita, Komae, Tokyo, 201 8511, Japan
    Radiat Res 163:153-8. 2005
    ....
  90. ncbi Multi-detector row CT systems and image-reconstruction techniques
    Thomas G Flohr
    Siemens Medical Solutions, CT Division, Forchheim, Germany
    Radiology 235:756-73. 2005
    ..Finally, the evolutionary steps from traditional single-section spiral image-reconstruction algorithms to the most recent approaches toward multisection spiral reconstruction are traced...
  91. ncbi Out-of-field photon and neutron dose equivalents from step-and-shoot intensity-modulated radiation therapy
    Stephen F Kry
    Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 62:1204-16. 2005
    ..intensity-modulated radiation therapy [IMRT]) at different treatment energies and delivered by different accelerators...
  92. ncbi Small-animal X-ray dose from micro-CT
    John M Boone
    Department of Radiology, UC Davis Medical Center, 4701 X Street, X ray Imaging Laboratory Sacramento, CA 95817, USA
    Mol Imaging 3:149-58. 2004
    ..80, 0.63, 0.52, and 0.44 mGy/mGy for mouse diameters of 10, 20, 30, and 40 mm, respectively. A number of tables and figures are provided for dose estimation over a range of mouse imaging geometries...
  93. ncbi Gene expression profiles of normal human fibroblasts after exposure to ionizing radiation: a comparative study of low and high doses
    Liang Hao Ding
    Lawrence Berkeley National Laboratory, Life Sciences Division, Berkeley, California, 94720, USA
    Radiat Res 164:17-26. 2005
    ..These quantitative and qualitative differences in gene expression changes may help explain the non-linear correlation of biological effects of ionizing radiation from low dose to high dose...
  94. ncbi Visual field preservation after multisession cyberknife radiosurgery for perioptic lesions
    John R Adler
    Department of Neurosurgery, Stanford University Medical School, Stanford, California, USA
    Neurosurgery 59:244-54; discussion 244-54. 2006
    ..The current retrospective study is intended to help address these shortcomings...
  95. ncbi Radiation exposure to the surgeon and the patient during kyphoplasty
    Thomas E Mroz
    Spine Institute, Cleveland Clinic Foundation, Cleveland, OH, USA
    J Spinal Disord Tech 21:96-100. 2008
    ..Prospective study of patients who underwent single or multilevel kyphoplasty for vertebral fractures...
  96. ncbi Diagnostic CT scans: assessment of patient, physician, and radiologist awareness of radiation dose and possible risks
    Christoph I Lee
    Department of Diagnostic Radiology, Yale University, 333 Cedar St, TE 2, New Haven, CT 06520, USA
    Radiology 231:393-8. 2004
    ..To determine the awareness level concerning radiation dose and possible risks associated with computed tomographic (CT) scans among patients, emergency department (ED) physicians, and radiologists...
  97. ncbi Treatment of salivary gland neoplasms with fast neutron radiotherapy
    James G Douglas
    Department of Radiation Oncology, University of Washington Cancer Center, Seattle, USA
    Arch Otolaryngol Head Neck Surg 129:944-8. 2003
    ..To evaluate the efficacy of fast neutron radiotherapy for the treatment of salivary gland neoplasms...
  98. ncbi Long-term effects of radiation dose on inflammatory markers in atomic bomb survivors
    Tomonori Hayashi
    Department of Radiobiology Molecular Epidemiology, Hiroshima University Faculty of Dentistry, Hiroshima, Japan
    Am J Med 118:83-6. 2005
  99. pmc Doctors' knowledge of radiation exposure: questionnaire study
    S Shiralkar
    Russells Hall Hospital, Dudley, West Midlands DY1 2HQ
    BMJ 327:371-2. 2003
  100. ncbi Radiation dose of cardiac computed tomography - what has been achieved and what needs to be done
    Hatem Alkadhi
    Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Raemistr 100, 8091, Zurich, Switzerland
    Eur Radiol 21:505-9. 2011
    ..It also briefly discusses two further methods of dose reduction, namely minimisation of the x-y anatomical coverage and adaptive statistical iterative reconstruction...
  101. ncbi Image quality and radiation exposure with a low tube voltage protocol for coronary CT angiography results of the PROTECTION II Trial
    Jorg Hausleiter
    Klinik für Herz und Kreislauferkrankungen, Deutsches Herzzentrum Munchen, Klinik an der Technischen Universität München, Munich, Germany
    JACC Cardiovasc Imaging 3:1113-23. 2010
    ..The purpose of this study was to evaluate image quality and radiation dose using a 100 kVp tube voltage scan protocol compared with standard 120 kVp for coronary computed tomography angiography (CTA)...

Research Grants75

  1. MECHANISMS OF FIBER CARCINOGENESIS
    TOM HEI; Fiscal Year: 2001
    ..Cytogenetic and molecular alterations at the gene level will be analyzed from tumors and intermediate transformation stages to provide a mechanistic basis for tumor induction by mineral fibers. ..
  2. Function domains of Ku proteins as molecular targets
    Fanqing Chen; Fiscal Year: 2003
    ..However, cytotoxicity induced by ionizing radiation limits the radiation dosage that can be administrated to patients...
  3. AUTOMATIC CORRECTION OF MOTION ARTIFACTS IN MR IMAGES
    Armando Manduca; Fiscal Year: 2007
    ..They represent perhaps the most flexible and universally applicable techniques for the correction of motion (and other) artifacts in MR imaging. ..
  4. INTRACAVITARY HYPERTHERM & RADIATN OF ESOPHAGEAL CANCER
    C Chou; Fiscal Year: 1993
    ..Intracavitary radiation has the advantage of localizing radiation but also causes ulceration due to high radiation dosage. Hyperthermia can potentiate the radiation effects and therefore reduces the required dose...
  5. EFFECT OF LASER RADIATION ON PERIODONTOPATHIC BACTERIA
    CLAY HENRY; Fiscal Year: 1990
    ..The effect of laser radiation will be assessed as a function of radiation wavelength, radiation dosage, and bacterial cell concentration, both in growth and non-growth environments...
  6. X-Ray Scattering Bone Densitometry
    MIODRAG KRMAR; Fiscal Year: 2006
    ..can offer a high quality in-vivo measurement of BMD by overcoming prior CCSR limitations, such as high radiation dosage, high system cost and long examining time...
  7. Micro Computerized Tomography Imaging System
    PETER CONTI; Fiscal Year: 2004
    ..ultra-high (10 fm) spatial resolution and sophisticated analysis software for bone studies, acceptable radiation dosage for serial scanning applications in living animals, physiologic gating capability for high resolution in vivo ..
  8. Non-Invasive Localization of Vulnerable Plaques
    Cynthia McCollough; Fiscal Year: 2009
    ....
  9. Neonatal Chest Phantom for Computed Radiography Testing
    Steven Don; Fiscal Year: 2006
    ..abstract_text> ..
  10. Cancer Risks Attributable To Radiation from Pediatric CT
    David Brenner; Fiscal Year: 2006
    ..The target audiences will be radiologists, pediatricians, family physicians, and the CT industry. We will use telephone interviews supplemented with survey questions, to aid in web content decisions. ..
  11. High Stability Accelerator for Sub-Cellular Microbeam
    David Brenner; Fiscal Year: 2003
    ..We have considerably more demand for microbeam time than we can cope with, primarily because of limited physicist manpower. ..
  12. Bi-Plane Correlation Imaging: Detection of Lung Cancer
    Ehsan Samei; Fiscal Year: 2007
    ..The findings will be used to substantiate the capability of BCI for improving the early detection of lung nodules and to optimize its performance on actual clinical cases. ..
  13. RADIOLOGICAL RESEARCH ACCELERATOR FACILITY (RARAF)
    David Brenner; Fiscal Year: 2002
    ..abstract_text> ..
  14. Early Detection of Lung Cancer via Bi Plane Correlation
    Ehsan Samei; Fiscal Year: 2002
    ..The findings will be used to demonstrate the capability of the approach for improving the detection of lung nodules, and thus the prognosis of lung cancer. ..
  15. Resolution requirements for mammographic displays
    Ehsan Samei; Fiscal Year: 2004
    ..The results will be used to formulate recommendations to the breast imaging community concerning display resolution criteria for safe and optimized soft-copy display of digital mammograms. ..
  16. Investigation of Monte Carlo Tools for IMRT
    Chang Ming Ma; Fiscal Year: 2005
    ..The results will be used as reference materials in retrospective studies as well as ongoing clinical trials. ..
  17. Spinal Cord Tolerance to Radiosurgical Dose Delivery
    Paul M Medin; Fiscal Year: 2010
    ....
  18. Immune Reconstitution in Nonhuman Primates
    Thomas Macvittie; Fiscal Year: 2005
    ..Clearly the ability to colonize mucosal surfaces in the respiratory, intestinal, and genital tracts also require the orchestrated synthesis of fimbriae for adherence and flagella for motility. ..
  19. Prostate Edema in Permanent Interstitial Brachytherapy
    Zhe Chen; Fiscal Year: 2010
    ..The primary objective of this project is to develop a new method to consider the effects of edema in radiation dosimetry and treatment planning so that the efficacy of this therapy can be optimized for each patient. ..
  20. THE MUTAGENICITY OF MINERAL FIBERS
    TOM HEI; Fiscal Year: 2006
    ..By using specific DNA probes of other genes that have been regionally mapped to various sites on chromosome 11, the molecular spectrum of mutations induced by either asbestos or glass fiber control will be compared. ..
  21. MECHANISMS OF ARSENIC CARCINOGENESIS
    TOM HEI; Fiscal Year: 2005
    ..abstract_text> ..
  22. Occupational exposures and brain cancer
    Elisabeth Cardis; Fiscal Year: 2010
    ..Further analyses of possible interactions between EMF and specific chemicals will also be conducted. ..
  23. Interaction of Radiation, BRCA1/2, and Breast Cancer
    Jonine Bernstein; Fiscal Year: 2006
    ..Once our study has been completed, we will have established an outstanding resource for future studies of other putative breast cancer genes and environmental exposures, with a particular focus on radiation exposure. ..
  24. Language, Literacy, Culture: Communication of Health Concepts
    DOUGLAS BRUGGE; Fiscal Year: 2006
    ....
  25. Assessment of Variance Structure in ROC Studies
    David Gur; Fiscal Year: 2006
    ..e., those that are the less demanding of the expensive resources of gathering patient cases and expanding radiologists reading time. ..
  26. Mouse Modeling Techniques for Bioluminescence Tomography
    Wenxiang Cong; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  27. Molecular Change and Thyroid Cancer Risk After Chernobyl
    Scott Davis; Fiscal Year: 2006
    ..g. recurrence) and individual thyroid radiation dose, patient characteristics, and molecular markers of genetic change. [unreadable] [unreadable]..
  28. Delayed Radioprotection by Thiols
    DAVID GRDINA; Fiscal Year: 2006
    ..Two, elevation in MnSOD level without a concomitant increase in enzymatic activity can result from nitration of MnSOD by peroxynitrite (ONOO-). ..
  29. Prediction of Second Cancer Risks for Children Treated with Proton - vs. - Photon
    Wayne D Newhauser; Fiscal Year: 2010
    ..In the future, we expect that the lower-risk treatments will result in fewer second cancers and this will translate into longer, higher-quality lives for survivors of childhood cancer (presently 270,000 persons in the United States). ..
  30. Phase Contrast Computed Tomography Scanner
    Edwin Donnelly; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  31. Heat Activated Gene Therapy Using Radiomimetic CdtB
    Michael Borrelli; Fiscal Year: 2007
    ..Consequently, complementary therapies that can improve local control for primary and recurrent cancers are needed. The proposed study will test the potential of heat-activated CdtB gene therapy to help satisfy this need. ..
  32. NIGHT SHIFT WORKERS AND HORMONE LEVELS IN WOMEN
    Scott Davis; Fiscal Year: 2006
    ..Urine samples will be assayed for the primary urinary metabolite of melatonin, 6-sulphatoxymelatonin, and levels of LH, FSH, and estradiol. ..
  33. Impact of Comorbidities on Outcomes of Allogeneic Transplantation
    Mohamed Sorror; Fiscal Year: 2008
    ..abstract_text> ..
  34. Comparing Performance Under FROC Paradigm - A Non Parametirc Approach
    David Gur; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  35. Breast Cancer, Radiation and the ATM-CHEK2 Pathway
    Jonine Bernstein; Fiscal Year: 2008
    ..Conduct a population-based case-control association study of 6 genes involved in the ATM-CHEK2 pathway to determine whether they are associated with an increased risk of radiation-induced contralateral breast cancer. ..
  36. Positron Emission Tomography in Prostate Cancer
    Farrokh Dehdashti; Fiscal Year: 2008
    ..PET may also contribute significant prognostic information that may affect the decision to administer early adjuvant therapy to delay or prevent recurrence. [unreadable] [unreadable]..
  37. ROC Analysis of Imaging System Evaluations
    David Gur; Fiscal Year: 2009
    ..We will develop closed-form solutions for the ANOVA procedure conducted on all possible bootstrap values. ..
  38. High End Computing for PET/SPECT
    DEAN WONG; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  39. Temporal Variation of Organ Dose Distribution in RT
    Di Yan; Fiscal Year: 2007
    ..Explore practical methods to include temporal variation of organ dose distribution, estimated from image feedback, in treatment planning optimization. ..
  40. Advances in Skeletal Dosimetry Through Microimaging
    Wesley Bolch; Fiscal Year: 2006
    ..abstract_text> ..
  41. Genetic Consequences of Therapies for Cancer
    John Boice; Fiscal Year: 2009
    ..abstract_text> ..
  42. Image Reconstruction with Solid Srate SPECR
    LAWRENCE ZENG; Fiscal Year: 2005
    ..abstract_text> ..
  43. Bone Marrow Fat and Osteopenia in HIV Lipodystrophy
    Jeannie Huang; Fiscal Year: 2006
    ....
  44. OBSERVER PERFORMANCE STUDIES-READER SELECTION & TRAINING
    David Gur; Fiscal Year: 2002
    ..While they proposed to continue to investigate several aspects in this regard, the current proposal would focus on the possible effects of observer (reader) selection and training on study design and results. ..
  45. 131 I-MIBG Escalating Dose Rapid Sequence Double Infusi*
    Katherine Matthay; Fiscal Year: 2004
    ..Significance: The higher tumor-specific radiation doses possible with this protocol may provide a treatment to improve response and survival in children with resistant neuroblastoma. ..
  46. Radio-Immunotherapy (RIT) Planning Using SPECT
    LAWRENCE ZENG; Fiscal Year: 2004
    ..Novel image reconstruction algorithms will be developed to provided quantitative SPECT images. Our hypothesis will be verified through human observer studies and Channelized Hotelling observer studies. ..
  47. ROC Analysis of Imaging System Evaluations
    David Gur; Fiscal Year: 2002
    ..abstract_text> ..
  48. CHILDRENS CANCER GROUP
    Katherine Matthay; Fiscal Year: 2002
    ..Our strong biology research laboratories in brain tumors, neuroblastoma and myeloproliferative disorders are conducting multiple biology studies in the Group and providing new information for future studies. ..
  49. Dedicated High Performance Human Brain/Preclinical PET
    DEAN WONG; Fiscal Year: 2004
    ..abstract_text> ..
  50. MECHANISMS OF DOPAMINE & SEROTONIN IN TOURETTE SYNDROME
    DEAN WONG; Fiscal Year: 2003
    ..We propose to carry out experiments using PET to establish a more complete understanding of the neurotransmission in TS. This will also help establish new ationales for improved therapeutics in TS. ..
  51. EXPERIMENTAL RADIOTHERAPY--CARCINOGENESIS, AND PROTECTOR
    DAVID GRDINA; Fiscal Year: 2003
    ..abstract_text> ..
  52. TOMOGRAPHIC DOSIMETRY PHANTOMS FOR PEDIATRIC RADIOLOGY
    Wesley Bolch; Fiscal Year: 2002
    ....
  53. Eliciting Truly Informed Consent
    William Hendee; Fiscal Year: 2003
    ..abstract_text> ..
  54. PREVALENCE EFFECT IN IMAGING SYSTEMS EVALUATIONS
    David Gur; Fiscal Year: 2001
    ..abstract_text> ..
  55. TOMOGRAPHIC DOSIMETRY PHANTOMS FOR PEDIATRIC RADIOLOGY
    Wesley Bolch; Fiscal Year: 2001
    ....
  56. IMAGING DOPAMINE/SEROTONIN MECHANISMS IN COCAINE CRAVING
    DEAN WONG; Fiscal Year: 2003
    ..Testing of these hypotheses will provide novel and fundamental answers to craving mechanisms. ..
  57. Antiproliferative Rx for venous neointimal hyperplasia
    Prabir Roy Chaudhury; Fiscal Year: 2005
    ..We believe that the results from this study could transform the clinical care of hemodialysis patients and at the same time result in the successful clinical application of local therapy for the treatment of neointimal hyperplasia...
  58. Monochromatic Phase-Contrast Breast Cancer Radiography
    Edwin Donnelly; Fiscal Year: 2005
    ..Image quality of all images will be judged by an experienced mammographer. ..
  59. Bisphosphonate therapy for HIV-Associated osteopenia
    Jeannie Huang; Fiscal Year: 2005
    ..Finally, data generated by this pilot study will lay the foundation for future studies of bisphosphonate therapy in HIV-infected persons with bone disease. ..
  60. Breast Cancer Imaging Using a Solid-State SPECT Camera
    G Zeng; Fiscal Year: 2005
    ..abstract_text> ..
  61. CONSTITUTIVE STRESS PROTEINS AND STRESS TOLERANCE
    Michael Borrelli; Fiscal Year: 2002
    ....
  62. Specificity/Sensitivity in Mammographic Screening
    Daniel Kopans; Fiscal Year: 2006
    ..Tomosynthesis may result in improved detection, characterization and visualization of breast lesions which may ultimately reduce mortality from breast cancer, while dramatically reducing callback imaging studies. ..
  63. Role of EETs in Growth of Human Endothelial Cells
    Meetha Medhora; Fiscal Year: 2006
    ..It will impact on the potential for development of EETs as therapeutic agents during and after cardiac ischemia and acute lung injury. ..
  64. Cardiac MDCT for Early Triage of Patients with ACS
    Udo Hoffmann; Fiscal Year: 2008
    ..abstract_text> ..
  65. Small Field of View Gamma Camera for Scintimammography
    Michael O Connor; Fiscal Year: 2005
    ..abstract_text> ..
  66. CONTROL SELECTION METHODS FOR CHILDHOOD CANCER STUDIES
    Greta Bunin; Fiscal Year: 2009
    ..A feasible and valid control group is needed to ensure that studies of childhood cancer are scientifically valid and therefore, will provide results that can eventually lead to prevention of these cancers. ..
  67. IMAGING DOPAMINE RELEASE/ENDOCRINE CHANGES IN ALCOHOLISM
    DEAN WONG; Fiscal Year: 2004
    ..If the initial D2 receptor deficits are exacerbated by alcohol abuse one can envision a positive feedback loop hard to break. ..
  68. Radiopharmaceutical Dosimetry Symposium
    Michael Stabin; Fiscal Year: 2002
    ..abstract_text> ..
  69. Realistic Phantom Series for OLINDA/EXM Version 2
    Michael Stabin; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  70. VIRTUAL STROKE MODEL FOR STUDY OF BLADDER HYPERREFLEXIA
    Victor Pikov; Fiscal Year: 2005
    ..We hope that this project can lead to development of a better treatment of stroke-related bladder dysfunction. ..
  71. New Methods for Improved Image-based Dosimetry
    Michael Stabin; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  72. GENETICS AND INTERMITTENT MYOCARDIAL HYPOXIA
    John Baker; Fiscal Year: 2003
    ....
  73. Cardiovascular Risk 50 Years After Thymic Irradiation
    Michael Adams; Fiscal Year: 2007
    ..This group of individuals, if shown to be at high risk, constitutes a potentially huge number of persons who may benefit from additional preventive measures. ..
  74. AUTOMATIC CORRECTION OF MOTION ARTIFACTS IN MR IMAGES
    Armando Manduca; Fiscal Year: 2001
    ..They are applicable to both conventional and fast scan applications, and may be adaptable to many non- motion sources of artifacts as well. ..