electric stimulation

Summary

Summary: Use of electric potential or currents to elicit biological responses.

Top Publications

  1. ncbi Learning induces long-term potentiation in the hippocampus
    Jonathan R Whitlock
    Howard Hughes Medical Institute, Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 313:1093-7. 2006
  2. ncbi Lateral habenula as a source of negative reward signals in dopamine neurons
    Masayuki Matsumoto
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 4435, USA
    Nature 447:1111-5. 2007
  3. ncbi Facilitation of implicit motor learning by weak transcranial direct current stimulation of the primary motor cortex in the human
    Michael A Nitsche
    Department of Clinical Neurophysiology, University of Goettingen, Goettingen, Germany
    J Cogn Neurosci 15:619-26. 2003
  4. pmc Basal forebrain activation enhances cortical coding of natural scenes
    Michael Goard
    Howard Hughes Medical Institute, Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, University of California, Berkeley, California, USA
    Nat Neurosci 12:1444-9. 2009
  5. ncbi Storage of spatial information by the maintenance mechanism of LTP
    Eva Pastalkova
    Departments of Physiology, Pharmacology, and Neurology, Robert F Furchgott Center for Neural and Behavioral Science, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    Science 313:1141-4. 2006
  6. pmc Modulating parameters of excitability during and after transcranial direct current stimulation of the human motor cortex
    Michael A Nitsche
    Department of Clinical Neurophysiology, University of Gottingen, Robert Koch Str 40, 37075 Gottingen, Germany
    J Physiol 568:291-303. 2005
  7. ncbi Boosting slow oscillations during sleep potentiates memory
    Lisa Marshall
    University of Lubeck, Department of Neuroendocrinology, Haus 23a, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Nature 444:610-3. 2006
  8. ncbi Shaping the effects of transcranial direct current stimulation of the human motor cortex
    M A Nitsche
    Department for Clinical Neurophysiology, Georg August University, Goettingen, Germany
    J Neurophysiol 97:3109-17. 2007
  9. doi Local dendritic activity sets release probability at hippocampal synapses
    Tiago Branco
    MRC Laboratory for Molecular Cell Biology and Cell Biology Unit, University College London, Gower Street, London WC1E6BT, UK
    Neuron 59:475-85. 2008
  10. ncbi Dendritic hyperpolarization-activated currents modify the integrative properties of hippocampal CA1 pyramidal neurons
    J C Magee
    Neuroscience Center, Louisiana State University Medical Center, New Orleans, Louisiana 70112, USA
    J Neurosci 18:7613-24. 1998

Detail Information

Publications399 found, 100 shown here

  1. ncbi Learning induces long-term potentiation in the hippocampus
    Jonathan R Whitlock
    Howard Hughes Medical Institute, Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 313:1093-7. 2006
    ..Because the learning-induced synaptic potentiation occluded HFS-induced LTP, we conclude that inhibitory avoidance training induces LTP in CA1...
  2. ncbi Lateral habenula as a source of negative reward signals in dopamine neurons
    Masayuki Matsumoto
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 4435, USA
    Nature 447:1111-5. 2007
    ..These results suggest that the inhibitory input from the lateral habenula plays an important role in determining the reward-related activity of dopamine neurons...
  3. ncbi Facilitation of implicit motor learning by weak transcranial direct current stimulation of the primary motor cortex in the human
    Michael A Nitsche
    Department of Clinical Neurophysiology, University of Goettingen, Goettingen, Germany
    J Cogn Neurosci 15:619-26. 2003
    ..We conclude that the primary motor cortex is involved in the acquisition and early consolidation phase of implicit motor learning...
  4. pmc Basal forebrain activation enhances cortical coding of natural scenes
    Michael Goard
    Howard Hughes Medical Institute, Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, University of California, Berkeley, California, USA
    Nat Neurosci 12:1444-9. 2009
    ..Thus, the basal forebrain neuromodulatory circuit, which is known to be activated during aroused and attentive states, acts through both local and distributed mechanisms to improve sensory coding...
  5. ncbi Storage of spatial information by the maintenance mechanism of LTP
    Eva Pastalkova
    Departments of Physiology, Pharmacology, and Neurology, Robert F Furchgott Center for Neural and Behavioral Science, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    Science 313:1141-4. 2006
    ..Thus, the mechanism maintaining LTP sustains spatial memory...
  6. pmc Modulating parameters of excitability during and after transcranial direct current stimulation of the human motor cortex
    Michael A Nitsche
    Department of Clinical Neurophysiology, University of Gottingen, Robert Koch Str 40, 37075 Gottingen, Germany
    J Physiol 568:291-303. 2005
    ..In contrast, the after-effects of tDCS are due to shifts in intracortical inhibition and facilitation, and at least partly also to facilitatory I-wave interaction, which is controlled by synaptic activity...
  7. ncbi Boosting slow oscillations during sleep potentiates memory
    Lisa Marshall
    University of Lubeck, Department of Neuroendocrinology, Haus 23a, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Nature 444:610-3. 2006
    ..Our findings indicate that endogenous slow potential oscillations have a causal role in the sleep-associated consolidation of memory, and that this role is enhanced by field effects in cortical extracellular space...
  8. ncbi Shaping the effects of transcranial direct current stimulation of the human motor cortex
    M A Nitsche
    Department for Clinical Neurophysiology, Georg August University, Goettingen, Germany
    J Neurophysiol 97:3109-17. 2007
    ..For future applications of tDCS, such paradigms may help to achieve more selective tDCS effects...
  9. doi Local dendritic activity sets release probability at hippocampal synapses
    Tiago Branco
    MRC Laboratory for Molecular Cell Biology and Cell Biology Unit, University College London, Gower Street, London WC1E6BT, UK
    Neuron 59:475-85. 2008
    ..Our results indicate that local dendritic activity is the major determinant of basal release probability, and we suggest that this feedback regulation might be required to maintain synapses in their operational range...
  10. ncbi Dendritic hyperpolarization-activated currents modify the integrative properties of hippocampal CA1 pyramidal neurons
    J C Magee
    Neuroscience Center, Louisiana State University Medical Center, New Orleans, Louisiana 70112, USA
    J Neurosci 18:7613-24. 1998
    ..Overall, Ih acts to dampen dendritic excitability, but its largest impact is on the subthreshold range of membrane potentials where the integration of inhibitory and excitatory synaptic inputs takes place...
  11. ncbi Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN
    Min Zhao
    School of Medical Sciences and Department of Ophthalmology, University of Aberdeen, Aberdeen AB25 2ZD, UK
    Nature 442:457-60. 2006
    ..Manipulation of endogenous wound electric fields affects wound healing in vivo. Electric stimulation triggers activation of Src and inositol-phospholipid signalling, which polarizes in the direction of cell ..
  12. ncbi Synaptic tagging and long-term potentiation
    U Frey
    Federal Institute for Neurobiology, Gene Regulation and Plasticity, Magdeburg, Germany
    Nature 385:533-6. 1997
    ..The synaptic tag decays in less than three hours. These findings indicate that the persistence of LTP depends not only on local events during its induction, but also on the prior activity of the neuron...
  13. pmc Pharmacological modulation of cortical excitability shifts induced by transcranial direct current stimulation in humans
    M A Nitsche
    Department of Clinical Neurophysiology, Georg August University, Goettingen, Germany
    J Physiol 553:293-301. 2003
    ..The selective elimination of tDCS-driven excitability enhancements by carbamazepine proposes a role for this drug in focussing the effects of cathodal tDCS, which may have important future clinical applications...
  14. ncbi Receptive field plasticity profoundly alters the cutaneous parallel fiber synaptic input to cerebellar interneurons in vivo
    Henrik Jörntell
    Department of Physiological Sciences, Section for Neurophysiology, SE 221 84 Lund, Sweden
    J Neurosci 23:9620-31. 2003
    ..The CF response, which is crucial for the induction of the PF synaptic potentiation, was strong but variable and very different from the conventional EPSPs evoked by PFs...
  15. ncbi NMDA receptor subunit composition controls synaptic plasticity by regulating binding to CaMKII
    Andres Barria
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Neuron 48:289-301. 2005
    ..The switch from NR2B to NR2A content in synaptic NMDA-Rs normally observed in many brain regions may contribute to reduced plasticity by controlling the binding of active CaMKII...
  16. ncbi Millisecond-timescale, genetically targeted optical control of neural activity
    Edward S Boyden
    Department of Bioengineering, Stanford University, 318 Campus Drive West, Stanford, California 94305, USA
    Nat Neurosci 8:1263-8. 2005
    ..This technology allows the use of light to alter neural processing at the level of single spikes and synaptic events, yielding a widely applicable tool for neuroscientists and biomedical engineers...
  17. ncbi A temporally asymmetric Hebbian rule governing plasticity in the human motor cortex
    Alexander Wolters
    Human Cortical Physiology Laboratory, Department of Neurology, University of Rostock, Germany
    J Neurophysiol 89:2339-45. 2003
    ..Together with earlier findings, this study suggests that strict temporal Hebbian rules govern the induction of long-term potentiation/long-term depression-like phenomena in vivo in the human primary motor cortex...
  18. ncbi Rapid and persistent modulation of actin dynamics regulates postsynaptic reorganization underlying bidirectional plasticity
    Ken ichi Okamoto
    RIKEN MIT Neuroscience Research Center, The Picower Center for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Neurosci 7:1104-12. 2004
    ..This bidirectional regulation of actin is actively involved in protein assembly and disassembly and provides a substrate for bidirectional synaptic plasticity...
  19. ncbi Properties of somatosensory synaptic integration in cerebellar granule cells in vivo
    Henrik Jörntell
    Department of Experimental Medical Sciences, Section for Neuroscience, Biomedical Center F10, SE 221 84 Lund, Sweden
    J Neurosci 26:11786-97. 2006
    ....
  20. ncbi Frontal lobe inputs to the digit representations of the motor areas on the lateral surface of the hemisphere
    Richard P Dum
    Center for the Neural Basis of Cognition and Department of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 25:1375-86. 2005
    ..Overall, the laminar origins of neurons that interconnect the three cortical areas are typical of "lateral" interactions. Thus, from an anatomical perspective, this cortical network lacks a clear hierarchical organization...
  21. pmc An extremely rich repertoire of bursting patterns during the development of cortical cultures
    Daniel A Wagenaar
    Department of Physics, California Institute of Technology, Caltech 103 33, Pasadena, CA 91125, USA
    BMC Neurosci 7:11. 2006
    ..We followed 58 cultures of different densities--3000 to 50,000 neurons on areas of 30 to 75 mm2--growing on multi-electrode arrays (MEAs) during the first five weeks of their development...
  22. doi The effects of electrical microstimulation on cortical signal propagation
    Nikos K Logothetis
    Max Planck Institute for Biological Cybernetics, Tubingen, Germany
    Nat Neurosci 13:1283-91. 2010
    ..Taken together, our findings suggest that electrical stimulation disrupts cortico-cortical signal propagation by silencing the output of any neocortical area whose afferents are electrically stimulated...
  23. ncbi Excitability changes induced in the human primary visual cortex by transcranial direct current stimulation: direct electrophysiological evidence
    Andrea Antal
    Department of Clinical Neurophysiology, Georg August University, Gottingen, Germany
    Invest Ophthalmol Vis Sci 45:702-7. 2004
    ....
  24. doi The effects of motor cortex rTMS on corticospinal descending activity
    V Di Lazzaro
    Institute of Neurology, Universita Cattolica, L go A Gemelli 8, 00168 Rome, Italy
    Clin Neurophysiol 121:464-73. 2010
    ..These recordings provided insight into the physiological basis of the effects of rTMS and the specific motor cortical circuits involved...
  25. pmc Dissociating the roles of the cerebellum and motor cortex during adaptive learning: the motor cortex retains what the cerebellum learns
    Joseph M Galea
    Department of Physical Medicine and Rehabilitation, Johns Hopkins Medical Institution, Baltimore, MD 21231, USA
    Cereb Cortex 21:1761-70. 2011
    ..Furthermore, they show that is possible to enhance cerebellar function using tDCS...
  26. ncbi Effects of transcranial direct current stimulation over the human motor cortex on corticospinal and transcallosal excitability
    N Lang
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    Exp Brain Res 156:439-43. 2004
    ....
  27. pmc Direct control of paralysed muscles by cortical neurons
    Chet T Moritz
    Department of Physiology and Biophysics and Washington National Primate Research Center, University of Washington, Seattle, Washington 98195, USA
    Nature 456:639-42. 2008
    ..These results are the first demonstration that direct artificial connections between cortical cells and muscles can compensate for interrupted physiological pathways and restore volitional control of movement to paralysed limbs...
  28. pmc Odor representations in olfactory cortex: "sparse" coding, global inhibition, and oscillations
    Cindy Poo
    Department of Neuroscience, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Neuron 62:850-61. 2009
    ..Together, our results reveal that global inhibition and oscillations are major synaptic mechanisms shaping odor representations in olfactory cortex...
  29. ncbi Mechanisms of amygdala modulation of hippocampal plasticity
    Irit Akirav
    Laboratory of Behavioral Neuroscience, Department of Psychology, University of Haifa, Haifa 31905, Israel
    J Neurosci 22:9912-21. 2002
    ..Possibly, at the onset of an emotional event the stress hormones permissively mediate plasticity. However, their prolonged presence in the system may suppress the cognitive response to stress...
  30. doi Electrified minds: transcranial direct current stimulation (tDCS) and galvanic vestibular stimulation (GVS) as methods of non-invasive brain stimulation in neuropsychology--a review of current data and future implications
    Kathrin S Utz
    Clinical Neuropsychology Unit, Saarland University, Saarbruecken, Germany
    Neuropsychologia 48:2789-810. 2010
    ..We conclude that the literature suggests that tDCS and GVS are exciting and easily applicable research tools for neuropsychological as well as clinical-therapeutic investigations...
  31. ncbi Single granule cells reliably discharge targets in the hippocampal CA3 network in vivo
    Darrell A Henze
    Center for Molecular and Behavioral Neuroscience, Rutgers University, The State University of New Jersey, 197 University Avenue, Newark, New Jersey 07102, USA
    Nat Neurosci 5:790-5. 2002
    ..In addition, we suggest that information in single granule cells is converted into a temporal delay code in target CA3 pyramidal cells and interneurons. These data demonstrate how a neural circuit of the CNS may process information...
  32. pmc Restoration of grasp following paralysis through brain-controlled stimulation of muscles
    C Ethier
    Department of Physiology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, Illinois 60611, USA
    Nature 485:368-71. 2012
    ..We anticipate that in human patients, this neuroprosthesis would allow much more flexible and dexterous use of the hand than is possible with existing FES systems...
  33. pmc Boosting cortical activity at Beta-band frequencies slows movement in humans
    Alek Pogosyan
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London WC1N 3BG, UK
    Curr Biol 19:1637-41. 2009
    ....
  34. pmc Phasic excitation of dopamine neurons in ventral VTA by noxious stimuli
    Frédéric Brischoux
    Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom
    Proc Natl Acad Sci U S A 106:4894-9. 2009
    ..Taken together, our results indicate that there are 2 functionally and anatomically distinct VTA dopamine systems...
  35. ncbi Bistability of cerebellar Purkinje cells modulated by sensory stimulation
    Yonatan Loewenstein
    Department of Neurobiology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Nat Neurosci 8:202-11. 2005
    ..Purkinje cell bistability may have a key role in the short-term processing and storage of sensory information in the cerebellar cortex...
  36. doi Astrocytes display complex and localized calcium responses to single-neuron stimulation in the hippocampus
    Yann Bernardinelli
    Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada, H3G 1A4
    J Neurosci 31:8905-19. 2011
    ..This study provides a new perspective on the dynamic response property of astrocyte ensembles to neuronal activity...
  37. ncbi Neurogliaform neurons form a novel inhibitory network in the hippocampal CA1 area
    Christopher J Price
    Anatomical Neuropharmacology Unit, Medical Research Council, Oxford OX1 3TH, United Kingdom
    J Neurosci 25:6775-86. 2005
    ..Our data disclose a novel interneuronal network well suited for modulating the flow of information between the entorhinal cortex and CA1 hippocampus...
  38. doi Direct measurement of somatic voltage clamp errors in central neurons
    Stephen R Williams
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nat Neurosci 11:790-8. 2008
    ..These errors question the use of the somatic voltage clamp as a quantitative tool in dendritic neurons...
  39. ncbi Learning modifies subsequent induction of long-term potentiation-like and long-term depression-like plasticity in human motor cortex
    Ulf Ziemann
    Motor Cortex Laboratory, Clinic of Neurology, Johann Wolfgang Goethe University, D 60528 Frankfurt am Main, Germany
    J Neurosci 24:1666-72. 2004
    ..The same number of repeated slow thumb abduction movements did not result in learning and had no effects on PAS-induced plasticity. Findings support the view that learning in human M1 occurs through LTP-like mechanisms...
  40. ncbi Internal dynamics determine the cortical response to thalamic stimulation
    Jason N MacLean
    Howard Hughes Medical Institute, Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Neuron 48:811-23. 2005
    ..Our data demonstrate that precise spatiotemporal activity patterns can be triggered by thalamic inputs and indicate that the thalamus serves to release intrinsic cortical dynamics...
  41. pmc Direct current stimulation promotes BDNF-dependent synaptic plasticity: potential implications for motor learning
    Brita Fritsch
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 66:198-204. 2010
    ..We propose that tDCS may improve motor skill learning through augmentation of synaptic plasticity that requires BDNF secretion and TrkB activation within M1...
  42. ncbi The lower limb flexion reflex in humans
    Giorgio Sandrini
    University Center for Adaptive Disorders and Headache, IRCCS C Mondino Institute of Neurology Foundation, University of Pavia, Via Mondino 2, 27100 Pavia, Italy
    Prog Neurobiol 77:353-95. 2005
    ....
  43. doi Action potential generation requires a high sodium channel density in the axon initial segment
    Maarten H P Kole
    Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Garran Road, Canberra ACT 0200, Australia
    Nat Neurosci 11:178-86. 2008
    ..In conclusion, action potential generation requires a high Na(+) channel density at the AIS, which is maintained by tight anchoring to the actin cytoskeleton...
  44. ncbi Direct current stimulation over V5 enhances visuomotor coordination by improving motion perception in humans
    Andrea Antal
    Department of Clinical Neurophysiology, Georg August University of Gottingen, Goettingen, Germany
    J Cogn Neurosci 16:521-7. 2004
    ..The results also raise the possibility of the usefulness of tDCS in rehabilitation strategies for neurological patients with visuomotor disorders...
  45. ncbi Level of action of cathodal DC polarisation induced inhibition of the human motor cortex
    Michael A Nitsche
    Department of Clinical Neurophysiology, University of Goettingen, Robert Koch Str 40, 37075, Goettingen, Germany
    Clin Neurophysiol 114:600-4. 2003
    ..To induce prolonged motor cortical excitability reductions by transcranial direct current stimulation in the human...
  46. ncbi Short-term depression at thalamocortical synapses contributes to rapid adaptation of cortical sensory responses in vivo
    Sooyoung Chung
    Department of Biology and, Volen Center for Complex Systems, Brandeis University, Mailstop 008, 415 South Street, Waltham, MA 02454, USA
    Neuron 34:437-46. 2002
    ..These data strongly suggest that synaptic depression of thalamic input to the cortex contributes to the dynamic regulation of neuronal sensitivity during rapid changes in sensory input...
  47. ncbi Lateral habenula stimulation inhibits rat midbrain dopamine neurons through a GABA(A) receptor-mediated mechanism
    Huifang Ji
    Maryland Psychiatric Research Center and Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland 21228, USA
    J Neurosci 27:6923-30. 2007
    ..The habenulomesencephalic pathway, which is capable of transiently suppressing the activity of dopamine neurons at a population level, may represent an important component of the circuitry involved in encoding reward expectancy...
  48. ncbi Synaptic amplifier of inflammatory pain in the spinal dorsal horn
    Hiroshi Ikeda
    Department of Neurophysiology, Center for Brain Research, Medical University of Vienna, Vienna, Austria
    Science 312:1659-62. 2006
    ..This model integrates known signal transduction pathways of hyperalgesia without contradiction...
  49. doi Electrical fields in wound healing-An overriding signal that directs cell migration
    Min Zhao
    Department of Dermatology, University of California Davis, School of Medicine, Center for Neurosciences, 1515 Newton Ct, Davis, CA 95618 4859, USA
    Semin Cell Dev Biol 20:674-82. 2009
    ..One of the most challenging question is: How do cells sense the very weak electric signals? Clinically, it is highly desirable to develop practical and reliable technologies for wound healing management exploiting the electric signaling...
  50. pmc In vivo two-photon calcium imaging of neuronal networks
    Christoph Stosiek
    Physiologisches Institut, Ludwig Maximilians Universitat Munchen, Pettenkoferstrasse 12, 80336 Munich, Germany
    Proc Natl Acad Sci U S A 100:7319-24. 2003
    ..Thus, our results demonstrate the suitability of this technique for real-time analyses of intact neuronal circuits with the resolution of individual cells...
  51. pmc Physiology and anatomy of synaptic connections between thick tufted pyramidal neurones in the developing rat neocortex
    H Markram
    Max Planck Institut fur medizinische Forschung, Abteilung Zellphysiologie, Germany
    J Physiol 500:409-40. 1997
    ..neurones, which have their synaptic contacts preferentially located on basal and apical oblique dendrites, was due to differences in transmitter release probability of the projecting neurones and, to a lesser extent, to differenc..
  52. pmc Transcranial electric stimulation entrains cortical neuronal populations in rats
    Simal Ozen
    Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, New Jersey 07102, USA
    J Neurosci 30:11476-85. 2010
    ..8, 1.25 or 1.7 Hz) via electrodes placed on the surface of the skull or the dura. Transcranial electric stimulation (TES) reliably entrained neurons in widespread cortical areas, including the hippocampus...
  53. pmc CDK5 serves as a major control point in neurotransmitter release
    Sung Hyun Kim
    Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065, USA
    Neuron 67:797-809. 2010
    ..These studies thus pinpoint CDK5 as a major control point for modulation of neurotransmitter release in mammalian neurons...
  54. ncbi Dopamine D1/D5 receptors gate the acquisition of novel information through hippocampal long-term potentiation and long-term depression
    Neal Lemon
    Learning and Memory Research, Medical Faculty, and International Graduate School for Neuroscience, Ruhr University Bochum, 44780 Bochum, Germany
    J Neurosci 26:7723-9. 2006
    ..These findings suggest that the dopaminergic system, acting via D1/D5 receptors, gates long-term changes in synaptic strength and that these changes are a critical factor in the acquisition of novel information...
  55. ncbi Cellular effects of deep brain stimulation: model-based analysis of activation and inhibition
    Cameron C McIntyre
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21218, USA
    J Neurophysiol 91:1457-69. 2004
    ..In turn, the results of this study support the hypothesis of stimulation-induced modulation of pathological network activity as a therapeutic mechanism of DBS...
  56. doi Noninvasive brain stimulation improves language learning
    Agnes Floel
    Department of Neurology, University of Munster, Munster, Germany
    J Cogn Neurosci 20:1415-22. 2008
    ..Our results demonstrate that anodal tDCS is a promising technique to enhance language learning in healthy adults and may also have the potential to improve language reacquisition after stroke...
  57. ncbi Gain modulation from background synaptic input
    Frances S Chance
    Center for Neural Science, New York University, New York, NY 10003, USA
    Neuron 35:773-82. 2002
    ..These results suggest that, within active cortical circuits, the overall level of synaptic input to a neuron acts as a gain control signal that modulates responsiveness to excitatory drive...
  58. doi Frequency-dependent electrical stimulation of the visual cortex
    Ryota Kanai
    Institute of Cognitive Neuroscience and Dept of Psychology, University College London, 17 Queen Square, WC1N 3AR, London, UK
    Curr Biol 18:1839-43. 2008
    ..Our results suggest that tACS can be used as a noninvasive tool for establishing a causal link between rhythmic cortical activities and their functions...
  59. ncbi Probing the human vestibular system with galvanic stimulation
    Richard C Fitzpatrick
    Prince of Wales Medical Research Institute, Easy St, Randwick, Sydney, NSW 2031, Australia
    J Appl Physiol (1985) 96:2301-16. 2004
    ..Thus we propose the hypothesis that the otolithic component of the balance response originates from only the pars medialis of the utricular macula...
  60. doi Transcranial direct current stimulation (tDCS) in a realistic head model
    ROSALIND J SADLEIR
    J Crayton Pruitt Department of Biomedical Engineering, University of Florida, Box 116131, Gainesville, FL 32611 6131, USA
    Neuroimage 51:1310-8. 2010
    ..The modeling also suggests that more targeted stimulations might be achieved by different electrode topologies...
  61. ncbi GABAergic modulation of DC stimulation-induced motor cortex excitability shifts in humans
    Michael A Nitsche
    Department of Clinical Neurophysiology, University of Goettingen, Robert Koch Str 40, 37075 Goettingen, Germany
    Eur J Neurosci 19:2720-6. 2004
    ..Because intracortical inhibition and facilitation are not changed in this phase compared with pre-tDCS values, excitability changes originating from remote cortical or subcortical areas could be involved...
  62. ncbi Synaptic basis for intense thalamocortical activation of feedforward inhibitory cells in neocortex
    Scott J Cruikshank
    Department of Neuroscience, Division of Biology and Medicine, Box G LN, Brown University, Providence, Rhode Island 02912, USA
    Nat Neurosci 10:462-8. 2007
    ..These results demonstrate the importance of selective synaptic targeting and precise timing in the initial stages of neocortical processing...
  63. ncbi Modulation of synaptic plasticity by physiological activation of M1 muscarinic acetylcholine receptors in the mouse hippocampus
    Toru Shinoe
    Division of Neuronal Network, Department of Basic Medical Sciences, Institute of Medical Science, University of Tokyo, Tokyo, 108 8639, Japan
    J Neurosci 25:11194-200. 2005
    ..These results suggest that physiologically released ACh from cholinergic fibers modulates hippocampal synaptic plasticity through the postsynaptic M1 mAChR activation...
  64. pmc Activity-dependent gating of lateral inhibition in the mouse olfactory bulb
    ARMEN C AREVIAN
    Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Nat Neurosci 11:80-7. 2008
    ..These results show that this previously unknown mechanism for specifying lateral inhibitory connections allows functional inhibitory connectivity to be dynamically remapped to relevant populations of neurons...
  65. ncbi Alternative to hand-tuning conductance-based models: construction and analysis of databases of model neurons
    Astrid A Prinz
    Volen Center and Biology Department, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurophysiol 90:3998-4015. 2003
    ..In all cases, database searches can provide insight into how neuronal and network properties depend on the values of the parameters in the models...
  66. ncbi Somatosensory integration controlled by dynamic thalamocortical feed-forward inhibition
    Laetitia Gabernet
    Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland
    Neuron 48:315-27. 2005
    ..Hence, feed-forward inhibitory circuits, classically known to sharpen spatial contrast of tactile inputs, also increase the temporal resolution in the somatosensory cortex...
  67. ncbi Dynamics of sparsely connected networks of excitatory and inhibitory spiking neurons
    N Brunel
    LPS, Ecole Normale Superieure, Paris, France
    J Comput Neurosci 8:183-208. 2000
    ..In the slow oscillatory state, the network frequency depends mostly on the membrane time constant. Finite size effects in the asynchronous state are also discussed...
  68. doi Effects of electric stimulation-assisted cycling training in people with chronic stroke
    Thomas W Janssen
    Faculty of Human Movement Sciences, Research Institute MOVE, VU University Amsterdam, The Netherlands
    Arch Phys Med Rehabil 89:463-9. 2008
    ..can improve cycling performance, aerobic capacity, muscle strength, and functional performance and to determine if electric stimulation (ES) to the contralateral (paretic) leg during cycling has additional effects over cycling without ES.
  69. pmc How does transcranial DC stimulation of the primary motor cortex alter regional neuronal activity in the human brain?
    Nicolas Lang
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, United Kingdom
    Eur J Neurosci 22:495-504. 2005
    ..The extensive spatial and temporal effects of tDCS need to be taken into account when tDCS is used to modify brain function...
  70. ncbi Olfactory representations by Drosophila mushroom body neurons
    Glenn C Turner
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    J Neurophysiol 99:734-46. 2008
    ..By comparing activity patterns evoked by the same odors across olfactory receptor neurons and across KCs, we show that representations of different odors do indeed become less correlated as they progress through the olfactory system...
  71. doi Contribution of hippocampal and extra-hippocampal NR2B-containing NMDA receptors to performance on spatial learning tasks
    Jakob von Engelhardt
    Department of Clinical Neurobiology, University of Heidelberg, D 69120 Heidelberg, Germany
    Neuron 60:846-60. 2008
    ..Thus, both hippocampal and extra-hippocampal NR2B containing NMDA receptors critically contribute to spatial performance...
  72. pmc Endogenous electric fields may guide neocortical network activity
    Flavio Frohlich
    Department of Neurobiology, Kavli Institute of Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA
    Neuron 67:129-43. 2010
    ..This significant susceptibility of active networks to EFs that only cause small changes in membrane potential in individual neurons suggests that endogenous EFs could guide neocortical network activity...
  73. doi Enhancement of planning ability by transcranial direct current stimulation
    Colleen A Dockery
    Max Planck Graduate School of Neural and Behavioral Sciences, University of Tuebingen, D 72074 Tuebingen, Germany
    J Neurosci 29:7271-7. 2009
    ..In conclusion, the specific coupling of stimulation and training phase interventions may support the treatment of cognitive disorders involving frontal lobe functions...
  74. ncbi Recruitment patterns in human skeletal muscle during electrical stimulation
    Chris M Gregory
    Department of Physical Therapy, University of Florida, Room 1142, HPNP Bldg, 101 S Newell Dr, Gainesville, FL 32610, USA
    Phys Ther 85:358-64. 2005
    ..The authors believe the majority of evidence suggests that EMS-induced motor unit recruitment is nonselective and that muscle fibers are recruited without obvious sequencing related to fiber types...
  75. pmc Topographic spread of inferior colliculus activation in response to acoustic and intracochlear electric stimulation
    Russell L Snyder
    Epstein Laboratory, Department of Otolaryngology, University of California, San Francisco, CA 94143 0526, USA
    J Assoc Res Otolaryngol 5:305-22. 2004
    ..Bipolar stimulation with longitudinally oriented VP electrodes produced broad activation that tended to broaden as the separation between electrodes increased...
  76. ncbi Electrical stimulation of the midbrain for hearing restoration: insight into the functional organization of the human central auditory system
    Hubert H Lim
    Otorhinolaryngology Department, Hannover Medical University, 30625 Hannover, Germany
    J Neurosci 27:13541-51. 2007
    ..These findings provide some insight into how we may need to stimulate the midbrain to improve hearing performance with the AMI...
  77. pmc Controlling bursting in cortical cultures with closed-loop multi-electrode stimulation
    Daniel A Wagenaar
    Department of Physics, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 25:680-8. 2005
    ..This nonpharmacological method of controlling bursts will be a critical tool for exploring the information processing capacities of neuronal ensembles in vitro and has potential applications for the treatment of epilepsy...
  78. pmc Gating of sensory input at spinal and cortical levels during preparation and execution of voluntary movement
    Kazuhiko Seki
    Department of Neurophysiology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo 187 8502, Japan
    J Neurosci 32:890-902. 2012
    ..This suppression could be induced by a top-down gating mechanism to facilitate the preparation and execution of upcoming movement...
  79. ncbi Turning on and off recurrent balanced cortical activity
    Yousheng Shu
    Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA
    Nature 423:288-93. 2003
    ..These results confirm the long-hypothesized role of recurrent activity as a basic operation of the cerebral cortex...
  80. doi Randomised clinical trial: pregabalin attenuates experimental visceral pain through sub-cortical mechanisms in patients with painful chronic pancreatitis
    S S Olesen
    Mech Sense, Department of Gastroenterology, Aalborg Hospital, Aarhus University Hospital, Denmark
    Aliment Pharmacol Ther 34:878-87. 2011
    ..Pregabalin has a broad spectrum of analgesic and antihyperalgesic activity in both basic and clinical studies. However, its mechanisms and sites of action have yet to be determined in humans...
  81. ncbi Motor and phosphene thresholds: a transcranial magnetic stimulation correlation study
    L M Stewart
    Institute of Cognitive Neuroscience, 17 Queen Square, London WC1N 3AR, UK
    Neuropsychologia 39:415-9. 2001
    ..To investigate the stability of visual phosphene thresholds and to assess whether they correlate with motor thresholds...
  82. doi Neurophysiological correlates of nociceptive heterosynaptic long-term potentiation in humans
    Emanuel N van den Broeke
    The Department of Anesthesiology, Pain and Palliative Medicine, Pain and Nociception Neuroscience Research Group, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Neurophysiol 103:2107-13. 2010
    ..These findings suggest that HFS is capable of producing heterosynaptic spinal LTP that can be measured not only behaviorally but also using ERPs...
  83. pmc Input-specific GABAergic signaling to newborn neurons in adult dentate gyrus
    Sean J Markwardt
    Department of Neurobiology and Evelyn McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Neurosci 29:15063-72. 2009
    ....
  84. ncbi Three myosin heavy chain isoforms in type 2 skeletal muscle fibres
    S Schiaffino
    Institute of General Pathology, University of Padova, Italy
    J Muscle Res Cell Motil 10:197-205. 1989
    ..Muscles containing predominantly 2X-MHC display a velocity of shortening intermediate between that of slow muscles and that of fast muscles composed predominantly of 2B fibres...
  85. ncbi Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity
    Petti T Pang
    Section on Neural Development and Plasticity, Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development NICHD, Bethesda, MD 20892, USA
    Science 306:487-91. 2004
    ..Moreover, application of mBDNF is sufficient to rescue L-LTP when protein synthesis is inhibited, which suggests that mBDNF is a key protein synthesis product for L-LTP expression...
  86. ncbi A comprehensive review of the effects of rTMS on motor cortical excitability and inhibition
    Paul B Fitzgerald
    Alfred Psychiatry Research Centre, The Alfred and Monash University School of Psychiatry, Psychology and Psychological Medicine, Commercial Rd Melbourne, VIC 3004, Australia
    Clin Neurophysiol 117:2584-96. 2006
    ..Further research is required, however, before these paradigms can be more widely adopted...
  87. ncbi Modulation of cortical excitability by weak direct current stimulation--technical, safety and functional aspects
    Michael A Nitsche
    Department of Clinical Neurophysiology, University of Gottingen, Robert Koch Strasse 40, D 37075 Gotingen, Germany
    Suppl Clin Neurophysiol 56:255-76. 2003
  88. doi Network plasticity in cortical assemblies
    Michela Chiappalone
    Department of Neuroscience and Brain Technology, Italian Institute of Technology, Via Morego 30, Genova, Italy
    Eur J Neurosci 28:221-37. 2008
    ..This pilot study could represent a relevant step towards understanding plastic properties at the neuronal population level...
  89. pmc Determinants of the induction of cortical plasticity by non-invasive brain stimulation in healthy subjects
    M C Ridding
    The Robinson Institute, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, Australia
    J Physiol 588:2291-304. 2010
    ..A greater understanding of these determinants is critical for optimising the therapeutic applications of non-invasive brain stimulation techniques...
  90. ncbi Comparison of descending volleys evoked by transcranial magnetic and electric stimulation in conscious humans
    V Di Lazzaro
    Istituto di Neurologia, Universita Cattolica, Rome, Italy
    Electroencephalogr Clin Neurophysiol 109:397-401. 1998
    ..The present experiments were designed to compare the understanding of the transcranial electric and magnetic stimulation of the human motorcortex...
  91. ncbi Changes in corticomotor representations induced by prolonged peripheral nerve stimulation in humans
    M C Ridding
    University Department of Medicine and Department of Neurology, Royal Adelaide Hospital, South Australia 5000, Adelaide, Australia
    Clin Neurophysiol 112:1461-9. 2001
    ..Here we investigate whether prolonged peripheral nerve stimulation can induce reorganization within the human motor cortex...
  92. pmc The sites of neural adaptation induced by resistance training in humans
    Timothy J Carroll
    Perception and Motor Systems Laboratory, The School of Human Movement Studies, The University of Queensland, Brisbane, Queensland 4072, Australia
    J Physiol 544:641-52. 2002
    ..These results suggest that resistance training changes the functional properties of spinal cord circuitry in humans, but does not substantially affect the organisation of the motor cortex...
  93. ncbi Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996
    E M Wassermann
    Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1428, USA
    Electroencephalogr Clin Neurophysiol 108:1-16. 1998
    ....
  94. pmc Ivy cells: a population of nitric-oxide-producing, slow-spiking GABAergic neurons and their involvement in hippocampal network activity
    Pablo Fuentealba
    MRC Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, UK
    Neuron 57:917-29. 2008
    ....
  95. ncbi Fine-scale specificity of cortical networks depends on inhibitory cell type and connectivity
    Yumiko Yoshimura
    Systems Neurobiology Laboratories, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037 USA
    Nat Neurosci 8:1552-9. 2005
    ..Furthermore, fine-scale specificity depends on the type of inhibitory neuron and on direct connectivity between neighboring pyramidal-inhibitory neuron pairs...
  96. ncbi Acoustic environment determines phosphorylation state of the Kv3.1 potassium channel in auditory neurons
    Ping Song
    Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Neurosci 8:1335-42. 2005
    ..1 current, facilitating high-frequency spiking. Our results indicate that the intrinsic electrical properties of auditory neurons are rapidly modified to adjust to the ambient acoustic environment...
  97. ncbi Intracellular acidosis enhances the excitability of working muscle
    Thomas H Pedersen
    Department of Physiology, University of Aarhus, DK 8000, Denmark
    Science 305:1144-7. 2004
    ..These results implicate chloride ion channels in muscle function and emphasize that intracellular acidosis of muscle has protective effects during muscle fatigue...
  98. ncbi Modeling the current distribution during transcranial direct current stimulation
    Pedro Cavaleiro Miranda
    Faculty of Sciences, Institute of Biophysics and Biomedical Engineering, University of Lisbon, Campo Grande, 1749 016 Lisbon, Portugal
    Clin Neurophysiol 117:1623-9. 2006
    ..To investigate the spatial distribution of the magnitude and direction of the current density in the human head during transcranial direct current stimulation (tDCS)...
  99. pmc Bottom-up dependent gating of frontal signals in early visual cortex
    Leeland B Ekstrom
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Science 321:414-7. 2008
    ..We conclude that bottom-up activation is needed to enable top-down modulation of early visual cortex and that stimulus saliency determines the strength of this modulation...
  100. ncbi Exposure to acute stress blocks the induction of long-term potentiation of the amygdala-prefrontal cortex pathway in vivo
    Mouna Maroun
    The Brain and Behavior Center, Faculty of Science and Science Education, University of Haifa, Haifa, 31905, Israel
    J Neurosci 23:4406-9. 2003
    ....
  101. ncbi Changes in synaptic structure underlie the developmental speeding of AMPA receptor-mediated EPSCs
    Laurence Cathala
    1 Department of Pharmacology, University College London, UK
    Nat Neurosci 8:1310-8. 2005
    ..Our findings raise the possibility that structural alterations could be a general mechanism underlying the change in the time course of AMPAR-mediated synaptic transmission...

Research Grants81

  1. Electrical Stimulation for Hemiplegic Shoulder Pain
    John Chae; Fiscal Year: 2010
    ..We further postulate that ES improves glenohumeral stability by facilitating motor recovery. Thus we will evaluate the effects of these treatments on objective measures of poststroke motor recovery. ..
  2. Effects of Evoked Resistance Training and Testosterone after Spinal Cord Injury
    Ashraf Gorgey; Fiscal Year: 2012
    ..The completion of the proposed experiment will allow the candidate to compete as an independent research investigator. ..
  3. Autonomic and Antihypertensive Actions of Neuronal CGRP/RAMP1 Receptors
    Mark W Chapleau; Fiscal Year: 2013
    ..Inhibition of Ang II-mediated effects by activation of CGRP/RAMP1 receptors has widespread implications in hypertension and heart failure. ..
  4. Chronic Electrical Stimulation to Reduce Bladder Hyperreflexia after SCI
    Kenneth J Gustafson; Fiscal Year: 2012
    ..This approach is less invasive than existing devices and is expected to expand the population of individuals able to benefit from neural stimulation systems to restore bladder function. ..
  5. Virus-Host Interactions that Lead to Epilepsy
    Robert S Fujinami; Fiscal Year: 2013
    ..Therefore, new and novel approaches to this disease are warranted. ..
  6. Neural Representation of Reach-to-Grasp for Cortical FES Neuroprostheses
    Abidemi Bolu Ajiboye; Fiscal Year: 2012
    ..Advancements towards this end resulting from the proposed work could significantly improve the quality of life and care of Veterans that is expected after one experiences an impairment resulting in severe paralysis. ..
  7. Community Ambulation Following Hip Fracture
    Jay Magaziner; Fiscal Year: 2013
    ..This study will evaluate a 16-week multi-component exercise program provided to patients in their homes to determine if it is effective in improving the ability to walk independently in the community (i.e., community ambulation). ..
  8. Improving ambulatory community access after paralysis
    Rudi Kobetic; Fiscal Year: 2012
    ..Being able to walk should significantly improve their quality of life by reducing their disability. ..
  9. Hypothalamic Deep Brain Stimulation for Morbid Obesity:Development of a Pig Model
    William P Melega; Fiscal Year: 2010
    ..Electrical stimulation of the specific brain regions involved in feeding behavior will result in modulation of food intake and body weight. We will show that this intervention method is safe and effective for long term weight control. ..
  10. CRCNS: Computation-Enabled Adaptive Ventilatory Control System
    Ranu Jung; Fiscal Year: 2013
    ....
  11. Excitation-contraction Coupling in Normal and Dystrophic Mammalian Muscle
    Julio L Vergara; Fiscal Year: 2013
    ..The results will significantly broaden our understanding of muscle disease mechanisms and will potentially provide therapeutic molecular tools which are deemed necessary for further advances in gene therapy. ..
  12. DEPOLARIZATION-SECRETION COUPLING IN NERVE TERMINALS
    Jose R Lemos; Fiscal Year: 2012
    ..Only then can therapeutic drugs be targeted to physiologically relevant purinergic receptors to alleviate such diseases. ..
  13. Transcutaneous vagus nerve stimulation in cerebral ischemia
    Ilknur Ay; Fiscal Year: 2013
    ..If successful, the findings of these exploratory studies will be used in near future translational studies designed to optimize tVNS treatment for acute ischemic stroke in humans. ..
  14. Neurotransplantation and Training to Promote Recovery of Chronic SCI Cats
    Michel A Lemay; Fiscal Year: 2013
    ..This will be a novel application of neuroregeneration and neurorehabilitation techniques to increase our understanding of the potential for repair after SCI. ..
  15. Stimuli promoting the survival of spiral ganglion neurons
    Steven H Green; Fiscal Year: 2011
    ..Our research focuses on improving the survival and function of surviving neurons in order to improve the long-term efficacy of cochlear implants, currently used by over 40,000 Americans. ..
  16. Dorsal Column Stimulation as a New Therapy for Motor Disorders
    Miguel A L Nicolelis; Fiscal Year: 2013
    ..abstract_text> ..
  17. Wireless Implantable Monitor for Improved Neuromodulation
    Margot S Damaser; Fiscal Year: 2012
    ..Veterans constitute one quarter of the 250,000 people with SCI in the U.S. and there are 10,000 new SCI patients each year. Therefore this proposal is of high relevance to the VA. ..
  18. Response of aging intrinsic laryngeal muscles to chronic electrical stimulation
    Colleen A McMullen; Fiscal Year: 2013
    ....
  19. Prediction of Physiological Events in People with Sleep Disordered Breathing
    Jonathan A Waxman; Fiscal Year: 2011
    ..The capability to predict its adverse consequences will be an invaluable tool to improve the quality of life of people with SDB, reduce the associated costs, and improve public health ..
  20. Advanced technology for neural interfaces based on microstimulation
    DOUGLAS BUCHANAN MCCREERY; Fiscal Year: 2013
    ..This work also will serve as a test bed for the long-lived microstimulation arrays we will develop. ..
  21. Furlow Palatoplasty with Tensor Tenopexy for Otitis Media
    Joseph E Losee; Fiscal Year: 2013
    ..abstract_text> ..
  22. Role of MEF2 and neural activity in cortical synaptic weakening and elimination
    Kimberly M Huber; Fiscal Year: 2013
    ..In Aim 4 we will use optogenetics and electrical stimulation to establish an in vitro model of novelty-induced priming of LTD to reveal cellular mechanisms. ..
  23. STIMULATION-AUGMENTED EXERCISE AND NEUROMOTOR THERAPY
    Eric C Hartman; Fiscal Year: 2010
    ....
  24. Producing micturition by combined afferent and effernet electrical stimulation
    Kenneth J Gustafson; Fiscal Year: 2010
    ....
  25. Imaging cellular energy metabolism in brain slices using fluorescent biosensors
    REBECCA ANNE MONGEON; Fiscal Year: 2013
    ....
  26. Cross-modal re-organization in children with cochlear implants
    Julia Dee Campbell; Fiscal Year: 2013
    ..abstract_text> ..
  27. Synaptic regulation of single substantia nigra pars reticulata neurons
    STEVEN WILLIAM JOHNSON; Fiscal Year: 2012
    ..By characterizing how synaptic connections and modulatory transmitter systems regulate this pathway, our studies may provide useful information to improve the therapy of these human disorders. ..
  28. Concurrent Upper/Lower Extremity SCI Exercise with Stimulation
    LEE BARNETT; Fiscal Year: 2010
    ....
  29. Real-time imaging of tPA fluorescent hybrids in hippocampal neurons
    Janis E Lochner; Fiscal Year: 2011
    ..tPA-mediated extracellular proteolysis is also implicated in excitotoxic cell death and the neuronal degeneration associated with Alzheimer<s disease. ..
  30. Retraining Spinal Circuits With Robot-Assisted Functional Electrical Stimulation
    Deborah Won; Fiscal Year: 2013
    ..The proposed research is expected to lead to a more effective and useable technology for rehabilitating locomotor skills. ..
  31. Towards the neuronal correlates of visual awareness
    Gabriel Kreiman; Fiscal Year: 2009
    ..Our research efforts will investigate the types of neurons, locations, circuits, interactions and dynamics that give rise to visual perception. ..
  32. Electrical Stimulation to Restore Three Dimensional Vestibular Sensation
    Charles C Della Santina; Fiscal Year: 2012
    ....
  33. Bladder and Sphincter Control after Spinal Cord Injury
    Changfeng Tai; Fiscal Year: 2012
    ..Our new approach also preserves the spinal reflex functions for bowel and sexual organ, and more importantly provides people with SCI the opportunity to benefit from advances in neural regeneration and repair techniques in the future. ..
  34. CENTRAL THALAMIC DEEP BRAIN STIMULATION MODELS
    Nicholas D Schiff; Fiscal Year: 2013
    ..The studies proposed here will help to advance the necessary knowledge to advance and further develop a novel application of electrical brain stimulation aimed at improving the lives of patients suffering with these lifelong challenges. ..
  35. Identification of Responders to the FES Interventions in Stroke Population
    Rakesh Pilkar; Fiscal Year: 2013
    ....
  36. Auditory Processing of Stochastic FM in Relationship to Speech Perception
    STANLEY E SHEFT; Fiscal Year: 2011
    ..The long-term goal of this work is to develop a clinically feasible psychoacoustic measure of FM processing ability to assess, diagnosis, and aid in the remediation of difficulties with speech perception. ..
  37. Cranial Stimulation for Chemotherapy Symptoms in Breast Cancer
    Deborah B McGuire; Fiscal Year: 2013
    ..Results from this study may also help to identify more clearly the biological causes for common, distressing symptoms. ..
  38. Muscle Weakness and Post-Traumatic Knee OA
    Terese L Chmielewski; Fiscal Year: 2011
    ..UF provides an excellent training environment with state-of-the-art facilities and a large number of faculties with an expertise in rehabilitation research. ..
  39. Advancing Diagnosis and Functional Localization in Focal Epilepsy with Oxygen-Enh
    GIRIDHAR PADMANABHAN KALAMANGALAM; Fiscal Year: 2013
    ..In doing so, I will be firmly on the path of my long-term goal of a clinical research career in academic epileptology. ..
  40. Advanced Engineering Development of a Chronic Retinal Implant
    JOHN L contact WYATT; Fiscal Year: 2010
    ..abstract_text> ..
  41. STATIC AND DYNAMIC ORGANIZATION OF PRIMATE MOTOR CORTEX
    John P Donoghue; Fiscal Year: 2013
    ..Such signals could allow people with paralysis to regain complex functions like reach and grasp through robotic limbs that could operate usefully across a range of contexts. ..
  42. Effects of dietary obesity on midbrain dopamine systems
    EMMANUEL POTHOS; Fiscal Year: 2009
    ..neurons from inbred dietary obesity-prone and obesity-resistant neonatal rats to consider whether dopamine quantal release is higher in obesity-resistant animals before actual exposure to palatable diets and excessive weight gain ..
  43. The Role of Small Ankyrin 1 in the Sarcoplasmic Reticulum in Skeletal Muscle
    Andrew P Ziman; Fiscal Year: 2011
    ..My studies should provide insights into the mechanisms underlying the organization of the calcium stores, changes in which have been implicated in a range of diseases in heart and skeletal muscle. ..
  44. Neural Interface and Control Design to Restore Sensation in Amputees
    MATTHEW ANTHONY SCHIEFER; Fiscal Year: 2012
    ..The goal is for the amputee to feel where the prosthesis is in space as well as pressure that the prosthesis exerts on objects that the user manipulates. ..
  45. Insulin effects in the vagal complex
    Camille Bond Blake; Fiscal Year: 2013
    ..to the DMV by "uncaging" glutamate in these neurons and examining paired-pulse responses in the DMV to electric stimulation of the NTS...
  46. Motion-Specific Toy Controllers for Upper Extremity Rehabilitation in Children
    Joseph J Crisco; Fiscal Year: 2013
    ....
  47. Electrophysiological mapping of corticocollicular projections involved with tonot
    HUBERT HYUNGIL LIM; Fiscal Year: 2013
    ..Thus the clinical goal of our proposed studies is to better understand how to acoustically and/or electrically activate the auditory system to improve frequency coding properties important for speech perception or tinnitus suppression. ..
  48. Synaptic Mechanisms of Vestibular Efferent Responses
    JOSEPH CHRISTOPHER HOLT; Fiscal Year: 2012
    ..Deciphering how and when the vestibular efferent system modifies the initial stages of vestibular processing are crucial to understanding its role in vestibular physiology. ..
  49. Delivery of Channel Rhodopsin for Optogenetic Control of Neurons in the Cochlea
    Daniel J Lee; Fiscal Year: 2013
    ..We propose that photosensitization of SGCs and insertion of an optical electrode for controlled stimulation of the inner ear may provide the basis for future CI technology based on light. ..
  50. Evaluation of Wire Electrodes to Activate the Expiratory Muscles to Restore Cough
    Anthony F DiMarco; Fiscal Year: 2010
    ....
  51. Mechanisms of fusion and transmitter release in neurosecretion
    Manfred Lindau; Fiscal Year: 2012
    ..This project is aimed at elucidating the molecular structure and dynamics of the fusion pore and mechanism by which transmitters are released through the fusion pore. ..
  52. Deep Brain Stimulation in the Parkinsonian Monkey
    Jerrold L Vitek; Fiscal Year: 2012
    ....
  53. Non-contact Diffuse Optical Assessment of Pressure Ulcer and Therapy
    Guoqiang Yu; Fiscal Year: 2013
    ....
  54. Applying a Multidimensional Algorithm for Motor Control
    Emilio Bizzi; Fiscal Year: 2010
    ....
  55. Functional Electrical Stimulation Mediated Neuroplasticity
    Lynne R Sheffler; Fiscal Year: 2013
    ....
  56. Novel Treatment Strategies for Constipation and Role of Brain-Gut axis
    SATISH SC RAO; Fiscal Year: 2011
    ..These studies aim to define the mechanisms of, and evaluate new therapies for dyssynergia, rectal hyposensitivity and rectal hypersensitivity, and could significantly impact constipation treatments. ..
  57. Assessment and evaluation of Hill-type muscle models for predicting in vivo force
    Andrew A Biewener; Fiscal Year: 2011
    ....
  58. Fatigability, Gender, and Optimal Stimulation Parameters after Spinal Cord Injury
    CHRISTOPHER S BICKEL; Fiscal Year: 2010
    ..The overarching aim of this application is to improve NMES protocols for all patients with disabilities, with special attention to gender related differences in muscle fatigue. ..
  59. Neural Prosthetic Control of Continence and Micturition
    Warren M Grill; Fiscal Year: 2013
    ..Successful completion of this project will advance the development of an effective neural prosthetic system for restoration of bladder function. ..
  60. DBS of the pedunculopontine nucleus in Parkinsonian primate
    Jerrold L Vitek; Fiscal Year: 2010
    ..As a treatment of gait dysfunction, the utility of PPN DBS may extend beyond the PD population to other movement disorders, including progressive supranuclear palsy and multiple systems atrophy. ..
  61. Cellular mechanisms of dietary therapy for epilepsy
    GARY I YELLEN; Fiscal Year: 2013
    ....
  62. Stimulation Thresholds of Ganglion Cells in the Degenerate Retina
    Ralph J Jensen; Fiscal Year: 2011
    ....
  63. Functional Invitro CNS and PNS Myelination Model
    Stephen Lambert; Fiscal Year: 2013
    ..The results will provide a new foundation for understanding the pathologies associated with myelin disorders and for developing therapeutics aimed at alleviating these pathologies. ..
  64. Adaptive High Intensity Electrical Stimulation for Post-Surgical Rehabilitation
    Eric Hartman; Fiscal Year: 2009
    ..Quadriceps strengthening has been shown to improve gait and improve performance of activities of daily living (ADLs). There are approximately 100,000 ACLR and 400,000 TKA surgeries per year in the United States. ..
  65. 5 HYDROXTRYPTAMINE MECHANISMS OF HALLUCINOGENIC DRUGS
    DAVID MOKLER; Fiscal Year: 1992
    ....
  66. Dual-pulse electrical stimulation for gastroparesis
    Jiande Chen; Fiscal Year: 2004
    ..Once the efficacy of the proposed method is proven, an implantable stimulator will be developed and its long-term efficacy for the treatment of gastroparesis will be evaluated in a Phase II project. ..
  67. Applications of FES Artificial Walking for Cerebral Palsy
    Jessica Rose; Fiscal Year: 2009
    ....
  68. LIGHT STIMULATED CARDIAC PACING AND DEFIBRILLATION
    JULIET MORGAN; Fiscal Year: 1991
    ..to develop a cardiac pacemaker and an internal and external cardiac defibrillator using light instead of electric stimulation. This idea is based on the observation that light can increase the beating rate of neonatal rat and ..
  69. Neural Mechanisms of Reinforcement Learning in the Basal Ganglia
    Kareem Zaghloul; Fiscal Year: 2009
    ....
  70. Complex pitch perception in very-early implanted children
    Rosalie Uchanski; Fiscal Year: 2007
    ..The results of this research could affect the design of cochlear implants and the speech perception benefits that cochlear implant users receive. [unreadable] [unreadable] [unreadable]..
  71. CEREBRAL VESSEL INNERVATION IN HYPERTENSION
    Tony Lee; Fiscal Year: 2002
    ..This research is a step toward our long-term goal to define the transmitter mechanisms in cerebral vasodilation and constriction, and their alterations in cerebral vascular diseases. ..
  72. Anticonvulsant effects of novel concentric ring electrode electrical stimulation
    WALTER GRANT BESIO; Fiscal Year: 2010
    ..A non-invasive therapeutic strategy for bedside and/or out-of-hospital intervention can significantly improve morbidity and mortality, as well as reduce risk and cost of treatment. ..
  73. PRESERVING MOBILITY OF JRA CHILDREN USING NOCTURNAL TES
    MICHELLE URBAN; Fiscal Year: 1999
    ..If the efficacy of this intervention in preserving mobility is demonstrated, future research would explore the underlying neuromuscular and neuroendocrine mechanisms responsible for the clinical effect. ..
  74. PRESERVING MOBILITY OF JRA CHILDREN USING NOCTURNAL TES
    John McGuire; Fiscal Year: 2001
    ..If the efficacy of this intervention in preserving mobility is demonstrated, future research would explore the underlying neuromuscular and neuroendocrine mechanisms responsible for the clinical effect. ..
  75. DORSAL SPINAL CORD STIMULATION--VASODILATOR MECHANISMS
    Robert Foreman; Fiscal Year: 2001
    ....
  76. VIRAL-AUTONOMIC INTERACTIONS IN THE TRACHEA
    Cheryl Killingsworth; Fiscal Year: 1991
    ..Investigations of mechanisms will involve the use of specific blockers of arachidonic acid and metabolites. Airway reactivity in feline "asthma" will also be studied...
  77. Two-photon calcium imaging of the effects of cortical microstimulation
    R Reid; Fiscal Year: 2009
    ..Measuring how neurons respond to electrical stimulation will help devise better treatments for diseases of the brain. ..
  78. Deep Brain Stimulation Array for Neuromodulation
    RIO VETTER; Fiscal Year: 2007
    ..DBS is a common therapeutic approach for the treatment of Parkinson's Disease, and potentially other movement related disorders. [unreadable] [unreadable] [unreadable]..
  79. Dual Pulse Electrical Stimulation for Gastroparesis
    Jiande Chen; Fiscal Year: 2007
    ..A number of innovative ideas are incorporated into the proposed method to tackle abnormalities related to gastroparesis. [unreadable] [unreadable] [unreadable]..
  80. Neural Prosthetic Control of Continence and Micturition
    WARREN GRILL; Fiscal Year: 2003
    ..Successful completion of this project will lead to the development of an effective neural prosthetic system for restoration of bladder function. ..
  81. Novel Treatment for the Relief of Chronic Orofacial Pain
    Richard Weiner; Fiscal Year: 2009
    ..The innovation holds promise for vastly heightened efficacy while reducing the majority of safety risks and side- effects compared to existing pain management solutions. ..