- TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction
Kelvin Y Kwan
Department of Neurobiology and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Neuron 50:277-89. 2006
..TRPA1 is apparently not essential for hair-cell transduction but contributes to the transduction of mechanical, cold, and chemical stimuli in nociceptor sensory neurons...
- Touching a rubber hand: feeling of body ownership is associated with activity in multisensory brain areas
H Henrik Ehrsson
Wellcome Department of Cognitive Neurology, Institute of Neurology, London WC1N 3BG, United Kingdom
J Neurosci 25:10564-73. 2005
..We propose that this could be the mechanism for the feeling of body ownership...
- Central cancellation of self-produced tickle sensation
S J Blakemore
Wellcome Department of Cognitive Neurology, London, UK
Nat Neurosci 1:635-40. 1998
..This difference suggests that the cerebellum is involved in predicting the specific sensory consequences of movements, providing the signal that is used to cancel the sensory response to self-generated stimulation...
- Neural substrates of tactile imagery: a functional MRI study
Seung Schik Yoo
Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Neuroreport 14:581-5. 2003
..Our results suggest that the primary and secondary somatosensory areas are recruited during tactile imagery, and have partially overlapping neural substrates for the perception of tactile stimulation...
- Is that near my hand? Multisensory representation of peripersonal space in human intraparietal sulcus
Tamar R Makin
Neurobiology Department, Life Sciences Institute, Hebrew University, Jerusalem 91904, Israel
J Neurosci 27:731-40. 2007
..We therefore suggest that, whereas cortical regions within the posterior IPS and LOC represent hand-centered space in a predominantly visual manner, the anterior IPS uses multisensory information in representing perihand space...
- Thermosensory activation of insular cortex
A D Craig
Division of Neurosurgery, Barrow Neurological Institute, 350 West Thomas Rd, Phoenix, Arizona 85013, USA
Nat Neurosci 3:184-90. 2000
..Notably, perceived thermal intensity was well correlated with activation in the right (ipsilateral) anterior insular and orbitofrontal cortices...
- TRPA1 modulates mechanotransduction in cutaneous sensory neurons
Kelvin Y Kwan
Department of Neurobiology and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 29:4808-19. 2009
- Coding and use of tactile signals from the fingertips in object manipulation tasks
Roland S Johansson
Physiology Section, Department of Integrative Medical Biology, Umea University, SE 901 87 Umea, Sweden
Nat Rev Neurosci 10:345-59. 2009
..Analysis of signals in tactile afferent neurons and central processes in humans reveals how contact events are encoded and used to monitor and update task performance...
- A multisensory investigation of the functional significance of the "pain matrix"
Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, Oxford, UK
Neuroimage 54:2237-49. 2011
..Taken together, these findings suggest that the largest part of the fMRI responses elicited by phasic nociceptive stimuli reflects non nociceptive-specific cognitive processes...
- Unsupervised whisker tracking in unrestrained behaving animals
Undergraduate Program in Mathematics, University of Heidelberg, Heidelberg, Germany
J Neurophysiol 100:504-15. 2008
..e., speed, amplitude and duration) of whisker touch and finally show that whisker deprivation does not alter whisking kinematics during haptic exploration...
- Spontaneous pain, both neuropathic and inflammatory, is related to frequency of spontaneous firing in intact C-fiber nociceptors
Department of Physiology, Medical School, University of Bristol, Bristol BS8 1TD, United Kingdom
J Neurosci 26:1281-92. 2006
..Overall, SFL was related to SA rate in intact C-nociceptors. Both L5 degeneration and chromic gut cause inflammation. Therefore, both SA and SFL/spontaneous pain after nerve injury (mSNA) may result from cumulative neuroinflammation...
- Upper limb amputees can be induced to experience a rubber hand as their own
H Henrik Ehrsson
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
Brain 131:3443-52. 2008
- Similar electrophysiological changes in axotomized and neighboring intact dorsal root ganglion neurons
Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
J Neurophysiol 89:1588-602. 2003
- Individual differences in pain sensitivity: genetic and environmental contributions
Christopher S Nielsen
Division of Mental Health, Norwegian Institute of Public Health, P O Box 4404 Nydalen, NO 0403 Oslo, Norway
Pain 136:21-9. 2008
..It also indicates that differences in pain scale usage account for a minor portion of the variance, providing strong support for the validity of subjective pain ratings as measures of experienced pain...
- Receptive field plasticity profoundly alters the cutaneous parallel fiber synaptic input to cerebellar interneurons in vivo
Department of Physiological Sciences, Section for Neurophysiology, SE 221 84 Lund, Sweden
J Neurosci 23:9620-31. 2003
..The CF response, which is crucial for the induction of the PF synaptic potentiation, was strong but variable and very different from the conventional EPSPs evoked by PFs...
- Low-magnitude mechanical signals that stimulate bone formation in the ovariectomized rat are dependent on the applied frequency but not on the strain magnitude
Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY, USA
J Biomech 40:1333-9. 2007
..Ideally, such mechanical signals represent a non-pharmacologic means of controlling bone mass and morphology in spite of systemic pressures for bone resorption...
- The mechanical variables underlying object localization along the axis of the whisker
Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA
J Neurosci 33:6726-41. 2013
..More generally, our data imply that mice can measure the amplitudes of forces in the sensory follicles for tactile sensation...
- Treating pain with pain: supraspinal mechanisms of endogenous analgesia elicited by heterotopic noxious conditioning stimulation
Department of Systems Neuroscience, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Pain 152:428-39. 2011
..Functional magnetic resonance imaging shows how the human brain is involved in heterotopic noxious conditioning and reveals active supraspinal pain modulatory mechanisms during dual pain stimulation...
- A functional magnetic resonance imaging study on the neural mechanisms of hyperalgesic nocebo effect
Department of Psychiatry, Massachusetts General Hospital, Massachusetts General Hospital, Massachusetts Institute of Technology Harvard Medical School Athinoula A Martinos Center for Biomedical Imaging, Boston, Massachusetts 02215, USA
J Neurosci 28:13354-62. 2008
..In conclusion, we found evidence that nocebo hyperalgesia may be predominantly produced through an affective-cognitive pain pathway (medial pain system), and the left hippocampus may play an important role in this process...
- Neuronal basis for object location in the vibrissa scanning sensorimotor system
Department of Physics and Section of Neurobiology, University of California, San Diego, La Jolla, CA 92093, USA
Neuron 72:455-68. 2011
..Efferent signals in motor cortex report the range of the scan. Collectively, these signals allow the rodent to form a percept of object location...
- Individual sensitivity to pain expectancy is related to differential activation of the hippocampus and amygdala
Department of Psychology, University of Haifa, Mount Carmel, Haifa, Israel
Hum Brain Mapp 31:326-38. 2010
..Our findings suggest that the amygdala supports an innate tendency to approach or avoid pain as reflected in HA trait, whereas the hippocampus mediates the effect of context possibly via appraisal of the stimulus value...
- Fake hands in action: embodiment and control of supernumerary limbs
School of Psychology, University of Nottingham, University Park, Nottingham, NG7 2RD, UK
Exp Brain Res 204:385-95. 2010
..Thus, it would appear that fake limbs can be incorporated into the body schema as well as the body image, but while multiple limbs can be incorporated into the body image, the body schema can accommodate only one...
- Spinal GABA(A) and GABA(B) receptor pharmacology in a rat model of neuropathic pain
T Philip Malan
Department of Anesthesiology, The University of Arizona, Tucson, Arizona 85724 5114, USA
Anesthesiology 96:1161-7. 2002
..This study tests the hypothesis that loss of spinal activity of gamma-aminobutyric acid (GABA) contributes to the allodynia and hyperalgesia observed after peripheral nerve injury...
- Dynamic receptive fields of reconstructed pyramidal cells in layers 3 and 2 of rat somatosensory barrel cortex
Department of Cell Physiology, Max Planck Institute for Medical Research, Heidelberg, Germany
J Physiol 553:243-65. 2003
..We conclude that the lemniscal (barrel-related) and paralemniscal (septum-related) afferent inputs remain anatomically and functionally segregated in L2/3...
- Encoding of whisker vibration by rat barrel cortex neurons: implications for texture discrimination
Cognitive Neuroscience Sector, International School for Advanced Studies, 34014 Trieste, Italy
J Neurosci 23:9146-54. 2003
..We conclude that vibration kinetics are rapidly and reliably encoded in the firing rate of cortical ensembles. Therefore, the cortical representation of vibration speed could underlie texture discrimination...
- Activity-dependent development of tactile and nociceptive spinal cord circuits
Stephanie C Koch
Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom
Ann N Y Acad Sci 1279:97-102. 2013
- Cortical excitation and inhibition following focal traumatic brain injury
Ming chieh Ding
School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA
J Neurosci 31:14085-94. 2011
- Millisecond precision spike timing shapes tactile perception
Emily L Mackevicius
Department of Organismal Biology and Anatomy, University of Chicago, Chicago, Illinois 60637, USA
J Neurosci 32:15309-17. 2012
..In light of these results, the peripheral representation of complex skin vibrations draws a powerful analogy with the auditory and vibrissal systems...
- A sensory-labeled line for cold: TRPM8-expressing sensory neurons define the cellular basis for cold, cold pain, and cooling-mediated analgesia
Wendy M Knowlton
Neurobiology Section, Department of Biological Sciences, University of Southern California, Los Angeles, California 90089, USA
J Neurosci 33:2837-48. 2013
..Together, these data show that, although some limited cold sensitivity remains in Trpm8(-/-) mice, TRPM8 neurons are required for the breadth of behavioral responses evoked by cold temperatures...
- Fronto-parietal areas necessary for a multisensory representation of peripersonal space in humans: an rTMS study
Universita degli Studi di Bologna, Bologna, Italy
J Cogn Neurosci 23:2956-67. 2011
..These findings indicate that multisensory interaction around the hand depends on the functions of vPMc and PPc, thus pointing to the necessity of this human fronto-parietal network in multisensory representation of PPS...
- Excitability of Aβ sensory neurons is altered in an animal model of peripheral neuropathy
Yong Fang Zhu
Farncombe Family Digestive Health Research Institute, McMaster University, 1280 Main St West, HSC 3N5C, Hamilton, Ontario, Canada
BMC Neurosci 13:15. 2012
..Thus, the present study aimed at recording intracellularly from Aβ-fiber dorsal root ganglion (DRG) neurons and determining excitability of the peripheral receptive field, of the cell body and of the dorsal roots...
- Observing touch activates human primary somatosensory cortex
Brain Research Unit, Low Temperature Laboratory, Aalto University School of Science and Technology, 00076 Aalto, Espoo, Finland
Eur J Neurosci 31:1836-43. 2010
..The results suggest that when people observe somebody else being touched, activation of their own somatosensory circuitry may contribute to understanding of the other person's somatosensory experience...
- Augmented mechanical response of muscle thin-fiber sensory receptors recorded from rat muscle-nerve preparations in vitro after eccentric contraction
Department of Neural Regulation, Division of Regulation of Organ Function, Research Institute of Environmental Medicine, Nagoya, Japan
J Neurophysiol 94:2822-31. 2005
..These results suggest that augmentation of the mechanical response in muscle thin-fiber sensory receptors might be related to the muscle tenderness in DOMS after ECC...
- Absence of rapid sensory adaptation in neocortex during information processing states
Manuel A Castro-Alamancos
Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
Neuron 41:455-64. 2004
..The primary sensory thalamocortical pathway of alert and expectant animals is in the adapted state, which may be required for adequate sensory information processing...
- Behavioural and histological observations of sensory impairment caused by tight ligation of the trigeminal nerve in mice
Division of Dental Anaesthesiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
J Neurosci Methods 181:67-72. 2009
..Therefore, we suggest that our experimental mouse model could represent a new model for clarifying the mechanism of the sensory impairment caused by peripheral nerve injury...
- Functional MRI of working memory and selective attention in vibrotactile frequency discrimination
Imaging Research, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
BMC Neurosci 8:48. 2007
..To investigate selective attention, a distractor stimulus was occasionally presented contralaterally, simultaneous to the probe...
- The role of heterosynaptic facilitation in long-term potentiation (LTP) of human pain sensation
Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Mainz, Germany
Pain 139:507-19. 2008
..Because none of the changes in sensory parameters was unique for the site of conditioning stimulation, these data suggest that heterosynaptic interactions are the predominant mechanism of LTP in nociceptive pathways...
- Modulation of pain ratings by expectation and uncertainty: Behavioral characteristics and anticipatory neural correlates
Christopher A Brown
Human Pain Research Group, Clinical Sciences Building, Hope Hospital, Salford M6 8HD, United Kingdom
Pain 135:240-50. 2008
..This suggests that biasing of pain reports and LEPs by expectation involves temporally precise activity in specific cortical networks...
- Sensory stimulus evokes inhibition rather than excitation in cerebellar Purkinje cells in vivo in mice
Chun Ping Chu
College of Basic Medicine, Yanbian University, Yanji City, Jilin Province, China
Neurosci Lett 487:182-6. 2011
- Relief of itch by scratching: state-dependent inhibition of primate spinothalamic tract neurons
University of Minnesota, Minneapolis, USA
Nat Neurosci 12:544-6. 2009
- Test-retest and interobserver reliability of quantitative sensory testing according to the protocol of the German Research Network on Neuropathic Pain (DFNS): a multi-centre study
Klinik und Poliklinik fur Neurologie, Universitätsmedizin der Johannes Gutenberg Universität, Mainz, Germany
Pain 152:548-56. 2011
- VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch
Malin C Lagerström
Department of Neuroscience, Uppsala University, Box 593, 751 24 Uppsala, Sweden
Neuron 68:529-42. 2010
..This study establishes that VGLUT2 is a major player in TRPV1 thermal nociception and also serves to regulate a normal itch response...
- Fine detail of neurovascular coupling revealed by spatiotemporal analysis of the hemodynamic response to single whisker stimulation in rat barrel cortex
Department of Psychology, University of Sheffield, Sheffield S10 2TN, UK
J Neurophysiol 99:787-98. 2008
..These data confirm hemodynamics are capable of providing accurate "single-condition" maps of neural activity...
- Coordinate-based meta-analysis of experimentally induced and chronic persistent neuropathic pain
Functional Imaging Unit, Center for Diagnostic Radiology, University of Greifswald, Germany
Neuroimage 58:1070-80. 2011
..Activation clusters in the anterior cingulate cortex and caudal anterior insula suggest a strong emotional contribution to the processing of chronic neuropathic pain...
- Abnormal modulatory influence of diffuse noxious inhibitory controls in migraine and chronic tension-type headache patients
University Centre for Adaptive Disorders and Headache, IRCCS C Mondino Foundation, University of Pavia, Pavia, Italy
Cephalalgia 26:782-9. 2006
..Impairment of endogenous supraspinal pain modulation systems may contribute to the development and/or maintenance of central sensitization in primary headaches...
- Functional connectivity of the human insular cortex during noxious and innocuous thermal stimulation
Department of Neurology, University Hospital Erlangen, Erlangen, Germany
Neuroimage 54:1324-35. 2011
- The whole body receptive field of dorsal horn multireceptive neurones
Daniel Le Bars
INSERM, 2, rue d Alesia, 75014, Paris, France
Brain Res Brain Res Rev 40:29-44. 2002
- A Drosophila mechanosensory transduction channel
R G Walker
Department of Biology, Howard Hughes Medical Institute, University of California, San Diego, CA 92093 0649, USA
Science 287:2229-34. 2000
..nompC encodes a new ion channel that is essential for mechanosensory transduction. As expected for a transduction channel, D. melanogaster NOMPC and a Caenorhabditis elegans homolog were selectively expressed in mechanosensory organs...
- Evoked potentials generated by noxious stimulation in the human infant brain
Neuroscience, Physiology and Pharmacology, University College London, United Kingdom
Eur J Pain 14:321-6. 2010
..These results provide the first direct evidence of specific noxious-evoked neural activity in the infant brain and suggest that newborn infants are capable of the sensory-discriminative aspects of pain experience...
- Visual-vestibular interactive responses in the macaque ventral intraparietal area (VIP)
Laboratoire de Physiologie de la Perception et de l Action, CNRS College de France, 11 place Marcelin Berthelot, F 75231 Paris Cedex 05, France
Eur J Neurosci 16:1569-86. 2002
..These results, taken together with data on responses to optic flow stimuli obtained in a parallel study, strongly suggest an involvement of area VIP in the analysis and the encoding of self-motion...
- A combinatorial semaphorin code instructs the initial steps of sensory circuit assembly in the Drosophila CNS
The Solomon H Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Howard Hughes Medical Institute, Baltimore, MD 21205, USA
Neuron 70:281-98. 2011
..These results reveal that distinct semaphorin-mediated guidance functions converge at PlexB and are critical for functional neural circuit assembly...
- Effects of different viewing perspectives on somatosensory activations during observation of touch
Human Cortical Physiology Section and Stroke Neurorehabilitation Clinic, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
Hum Brain Mapp 30:2722-30. 2009
..Moreover, somatosensory responses differed depending on the perspective of the observed touch. We discuss the results in terms of a possible mirror neuron system for observed and experienced touch...
- An elegant mind: learning and memory in Caenorhabditis elegans
Evan L Ardiel
Brain Research Centre and Department of Psychology, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
Learn Mem 17:191-201. 2010
..Several genes have been identified with no known role other than mediating behavior plasticity...
- Hyper-responsivity in a subset of C-fiber nociceptors in a model of painful diabetic neuropathy in the rat
Departments of Anatomy, Medicine, and Oral and Maxillofacial Surgery, Division of Neuroscience, NIH Pain Center (UCSF, University of California, San Francisco 94143-0440, USA
Neuroscience 102:185-92. 2001
..The present findings suggest that study of individual neurons in vitro may allow elucidation of the ionic basis of enhanced nociception in diabetic neuropathy...
- Encoding of direction of fingertip forces by human tactile afferents
Department of Integrative Medical Biology, Physiology Section, Umea University, SE 901 87 Umea, Sweden
J Neurosci 21:8222-37. 2001
..We conclude that tactile afferents from the whole terminal phalanx potentially contribute to the encoding of direction of fingertip forces similar to those that occur when subjects manipulate objects under natural conditions...
- The influence of stimulus cue on the initiation of stepping in young and older adults
M W Rogers
Department of Physical Therapy and Human Movement Sciences, Northwestern University Medical School, Chicago, IL, USA
Arch Phys Med Rehabil 82:619-24. 2001
..The abilities of many older persons may be compromised in situations where rapid adjustments in the base of support through stepping are triggered by environmental stimuli...
- Synthesis of multiwhisker-receptive fields in subcortical stations of the vibrissa system
Centre de Recherche Universite Laval Robert Giffard, 2601 de la Canardiere, Quebec G1J 2G3, Canada
J Neurophysiol 91:1510-5. 2004
..07 whisker after the lesion. Together these results indicate that the synthesis of surround receptive fields in subcortical stations relies almost exclusively on intersubnuclear projections from the spinal trigeminal complex to the PrV...
- Tickling expectations: neural processing in anticipation of a sensory stimulus
Karolinska Institute Karolinska Hospital, Sweden
J Cogn Neurosci 12:691-703. 2000
..Moreover, this study indicates that activation of primary somatosensory cortex can be obtained without intra-modal sensory input. These findings suggest that anticipation may invoke a tonic top-down regulation of neural activity...
- Warm pleasant feelings in the brain
Edmund T Rolls
University of Oxford, Department of Experimental Psychology, South Parks Road, Oxford OX1 3UD, England, UK
Neuroimage 41:1504-13. 2008
..This conclusion appears to be the case for processing in a number of sensory modalities, and the finding with such prototypical stimuli as warm and cold provides strong support for this principle...
- Realignment of temporal simultaneity between vision and touch
Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan
Neuroreport 19:319-22. 2008
..No intermanual transfer of the adaptation effect was, however, found. These results indicate that the perceptual simultaneity between vision and touch is adaptive, and is determined separately for each hand...
- Governing role of primary afferent drive in increased excitation of spinal nociceptive neurons in a model of sciatic neuropathy
Graham M Pitcher
Departments of Physiology and Psychiatry, McGill University, 3655 Sir William Osler, Montreal, Quebec, Canada H3G 1Y6
Exp Neurol 214:219-28. 2008
..Our findings reveal that ectopic afferent activity from multiple regions along peripheral nerves may drive CNS changes and the symptoms of pain associated with peripheral neuropathy...
- Mechanical and heat sensitization of cutaneous nociceptors in rats with experimental peripheral neuropathy
Brain Research Institute, Brain Korea 21 Project for Medical Science, and Department of Physiology, Yonsei University College of Medicine, C P O Box 8044, 120 752, Seoul, South Korea
Neuroscience 132:193-201. 2005
..This nociceptor sensitization can contribute to neuropathic pain...
- Thalamic sensitization transforms localized pain into widespread allodynia
Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Boston, MA
Ann Neurol 68:81-91. 2010
- The role of fingerprints in the coding of tactile information probed with a biomimetic sensor
Laboratoire de Physique Statistique de l Ecole Normale Superieure, CNRS UMR 8550, Associé aux Universités Paris 6 et Paris 7, 24 rue Lhomond, 75231 Paris Cedex 05, France
Science 323:1503-6. 2009
..Thus, fingerprints may perform spectral selection and amplification of tactile information that facilitate its processing by specific mechanoreceptors...
- Role of primary afferent nerves in allodynia caused by diabetic neuropathy in rats
G M Khan
Department of Anesthesiology H187, Penn State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
Neuroscience 114:291-9. 2002
..Our electrophysiological data provide substantial new evidence that the abnormal sensory input from Adelta- and Abeta-fiber afferents may play an important role in diabetic neuropathic pain...
- Differential effect of steady versus oscillating flow on bone cells
C R Jacobs
Department of Orthopaedics and Rehabilitation, Penn State University, Hershey 17033, USA
J Biomech 31:969-76. 1998
..Thus. these findings support the hypothesis that the response of bone cells to fluid flow is dependent on chemotransport effects...
- Spatio-temporal prediction modulates the perception of self-produced stimuli
S J Blakemore
Wellcome Department of Cognitive Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
J Cogn Neurosci 11:551-9. 1999
..e., its tickliness) is proportional to the error between the sensory feedback predicted by an internal forward model of the motor system and the actual sensory feedback produced by the movement...
- Evidence of dysfunctional pain inhibition in Fibromyalgia reflected in rACC during provoked pain
Karin B Jensen
Stockholm Brain Institute, Osher Center for Integrative Medicine, Karolinska Institutet, Stockholm, Sweden
Pain 144:95-100. 2009
- Experimental and clinical applications of quantitative sensory testing applied to skin, muscles and viscera
Department of Health Sciences and Technology, Center for Sensory Motor Interaction, Aalborg University, Aalborg, Denmark
J Pain 10:556-72. 2009
..Assessing pain has become a question of solving a multi-input, multi-output problem, with the solution providing the possibility of teasing out which pain pathways and mechanisms are involved, impaired, or affected...
- Spike timing, spike count, and temporal information for the discrimination of tactile stimuli in the rat ventrobasal complex
Neurosignals Group, Hospital Nacional de Paraplejicos, Servicio de Salud de Castilla La Mancha, Toledo 45071, Spain
J Neurosci 29:5964-73. 2009
..We conclude that temporal information conveyed by spike timing can be higher than spike count information for the discrimination of somatosensory stimuli in the rat ventrobasal complex...
- Separate peripheral pathways for pruritus in man
Department of Physiology and Pathophysiology, University of Erlangen Nurnberg, Germany
J Neurophysiol 100:2062-9. 2008
..It is distinct from the pathway for histamine-mediated pruritus and does not involve the histamine-sensitive mechano-insensitive fibers...
- Formation of dendritic spines with GABAergic synapses induced by whisker stimulation in adult mice
Graham W Knott
Institut de Biologie Cellulaire et Morphologie, Universite de Lausanne, Rue du Bugnon 9, CH 1005, Lausanne, Switzerland
Neuron 34:265-73. 2002
..These results indicate activity-dependent alterations in synaptic circuitry in adulthood, modifying the flow of sensory information into the cerebral cortex...
- Discrimination of vibrotactile stimuli in the rat whisker system: behavior and neurometrics
Todor V Gerdjikov
Werner Reichardt Center for Integrative Neuroscience, University of Tubingen, 72076 Tübingen Germany
Neuron 65:530-40. 2010
..In conclusion, we suggest that stimulus mean absolute velocity, encoded in primary afferent spike counts, plays a prominent role for whisker-mediated perception...
- Mechanical, thermal and formalin-induced nociception is differentially altered in 5-HT1A-/-, 5-HT1B-/-, 5-HT2A-/-, 5-HT3A-/- and 5-HTT-/- knock-out male mice
University Pierre et Marie Curie Paris 6, Faculte de Medecine Pierre et Marie Curie, Site Pitié Salpêtrière, IFR 70 des Neurosciences, UMR S677, Paris, F 75013, France
Pain 130:235-48. 2007
..These results support the conclusion that the complex control of pain mechanisms by 5-HT, acting at multiple receptors, is physiologically relevant in mice...
- Somatosensory profiles in subgroups of patients with myogenic temporomandibular disorders and Fibromyalgia Syndrome
Doreen B Pfau
Department of Neurophysiology, Center of Biomedicine and Medical Technology Mannheim, Ruprecht Karls University Heidelberg, Mannheim, Germany
Pain 147:72-83. 2009
..g. a disturbance of central pain processing, in this subgroup of TMD patients. Those patients could be identified on the basis of their tender point count as an easy practicable screening tool...
- A common framework for perceptual learning
Aaron R Seitz
Department of Psychology, Boston University, 64 Cummington Street, Boston, MA 02215, USA
Curr Opin Neurobiol 17:148-53. 2007
- On the other hand: dummy hands and peripersonal space
Tamar R Makin
Department of Neurobiology, Life Sciences Institute, Hebrew University, Jerusalem 91904, Israel
Behav Brain Res 191:1-10. 2008
..Finally, we propose a simple model that situates the 'rubber hand illusion' in the neurophysiological framework of multisensory hand-centred representations of space...
- Perceptual correlate of nociceptive long-term potentiation (LTP) in humans shares the time course of early-LTP
Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Saarstrasse 21, D 55099 Mainz, Germany
J Neurophysiol 96:3551-5. 2006
..3 h. These findings suggest that a single HFS session induces nociceptive LTP in healthy subjects that corresponds to early-LTP (LTP1), implying primarily posttranslational mechanisms for this type of plasticity of human pain perception...
- A new model of sciatic inflammatory neuritis (SIN): induction of unilateral and bilateral mechanical allodynia following acute unilateral peri-sciatic immune activation in rats
Laboratory of Pathophysiology, Butantan Institute, Avenue Vital Brazil, 1500, 05503-900 Sao Paulo, SP, Brazil
Pain 94:231-44. 2001
..Since many clinical neuropathies result from inflammation/infection of peripheral nerves rather than frank physical trauma, understanding how immune activation alters pain processing may suggest novel approaches to pain control...
- Induction of Fos protein-like immunoreactivity in the trigeminal spinal nucleus caudalis and upper cervical cord following noxious and non-noxious mechanical stimulation of the whisker pad of the rat with an inferior alveolar nerve transection
Department of Anesthesiology, School of Dentistry, Nihon University, 1 8 13, Kanda Surugadai, Chiyoda ku, 101 8310, Tokyo, Japan
Pain 95:225-38. 2002
..These data suggest that the change in the numbers and spatial arrangement of nociceptive neurons in the Vc and C1 after IAN transection reflect the development of mechanical hyperalgesia in the area adjacent to the IAN innervated region...
- Differential effects of synchronous and asynchronous multifinger coactivation on human tactile performance
Department of Theoretical Biology, Institute for Neuroinformatics, Ruhr University Bochum, D 44780 Bochum Germany
BMC Neurosci 8:58. 2007
..Here we investigated the effect of different types of multifinger CA on the tactile performance of each finger of the right hand...
- Probing the human vestibular system with galvanic stimulation
Richard C Fitzpatrick
Prince of Wales Medical Research Institute, Easy St, Randwick, Sydney, NSW 2031, Australia
J Appl Physiol (1985) 96:2301-16. 2004
..Thus we propose the hypothesis that the otolithic component of the balance response originates from only the pars medialis of the utricular macula...
- Contribution of somatosensory cortex to responses in the rat cerebellar granule cell layer following peripheral tactile stimulation
Computation and Neural Systems Program, California Institute of Technology, Pasadena 91125, USA
Exp Brain Res 109:240-50. 1996
..Our results demonstrate that SI is the primary contributor to the cerebellar long-latency response to peripheral tactile stimulation. These results are discussed in the context of Purkinje cell responses to tactile input...
- The somatotopic organization of cytoarchitectonic areas on the human parietal operculum
Simon B Eickhoff
Institut fur Medizin, Forschungszentrum Julich, Julich, Germany
Cereb Cortex 17:1800-11. 2007
- Binding of movement, sound and touch: multimodal coordination dynamics
Laboratory Efficience Deficience Motrice, University Montpellier 1, 700 Avenue Pic Saint Loup, 34090 Montpellier, France
Exp Brain Res 173:673-88. 2006
..Because timing errors in multimodal coordination were systematically altered when compared to unimodal control conditions we are led to consider the role played by time delays in multimodal coordination dynamics...
- Tool use changes multisensory interactions in seconds: evidence from the crossmodal congruency task
Nicholas P Holmes
Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford OX1 3UD, UK
Exp Brain Res 183:465-76. 2007
..Such enhancements are likely due to the increased behavioural relevance of visual stimuli as each tool use action is prepared before execution...
- Parietal cortex involvement in the localization of tactile and noxious mechanical stimuli: a transcranial magnetic stimulation study
Carlo A Porro
Department of Biomedical Sciences, Section of Human Physiology, University of Modena and Reggio Emilia, Via Campi 287, 41100 Modena, Italy
Behav Brain Res 178:183-9. 2007
..On these grounds, our findings support the existence of overlapping cortical populations in the contralateral parietal lobe, exerting a role in spatial discriminative aspects of touch and mechanically induced pain...
- Dorsal root compression produces myelinated axonal degeneration near the biomechanical thresholds for mechanical behavioral hypersensitivity
Raymond D Hubbard
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA
Exp Neurol 212:482-9. 2008
..This study provides new evidence for threshold-mediated degenerative changes in the context of behavioral hypersensitivity following nerve root compression...
- Pain and tactile stimuli during arterial puncture in preterm neonates
Cláudia Maria Gaspardo
Department of Neurology, Psychiatry and Medical Psychology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil
Pain 140:58-64. 2008
..There was evidence of distress responses immediately before and after a painful event, quite apart from the pain reaction to the puncture procedure...
- Mechanical stretch promotes fetal type II epithelial cell differentiation via shedding of HB-EGF and TGF-alpha
Department of Pediatrics, Women and Infants Hospital of Rhode Island and the Warren Alpert Medical School of Brown University, Providence, RI 02905, USA
J Physiol 587:1739-53. 2009
..These studies provide novel mechanistic information potentially relevant to fetal lung development and to mechanical ventilation-induced lung injury...
- The effect of visual experience on the development of functional architecture in hMT+
Laboratory of Clinical Biochemistry and Molecular Biology, Department of Experimental Pathology, Medical Biotechnologies, Infectivology, and Epidemiology, University of Pisa Medical School, I 56126 Pisa, Italy
Cereb Cortex 17:2933-9. 2007
- Localization of sensorimotor cortical rhythms induced by tactile stimulation using spatially filtered MEG
Department of Diagnostic Imaging, Neuromagnetic Imaging Laboratory, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
Neuroimage 30:899-908. 2006
- Left tactile extinction following visual stimulation of a rubber hand
Department of Psychology, University of Bologna and S Camillo Hospital, Venezia, Italy
Brain 123:2350-60. 2000
- Neurovascular coupling is brain region-dependent
Ian M Devonshire
Department of Psychology, University of Sheffield, Western Bank, Sheffield, S10 2TN, United Kingdom
Neuroimage 59:1997-2006. 2012
..The findings have important implications for studies that use functional brain imaging to investigate sub-cortical function and caution against the use of simple, linear mapping of imaging signals onto neural activity...
- Optical imaging of a tactile illusion in area 3b of the primary somatosensory cortex
Li M Chen
Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06520, USA
Science 302:881-5. 2003
..Thus, in contrast to traditional views of the body map, topographic representation in the SI reflects the perceived rather than the physical location of peripheral stimulation...
- The effect of distraction strategies on pain perception and the nociceptive flexor reflex (RIII reflex)
Department of Neurology, University of Munster, Munster, Germany
Pain 152:2662-71. 2011
..In addition, pain reduction by distraction seems to preferentially affect mechanisms of basal nociceptive transmission, not of temporal summation...
- Working memory for vibrotactile frequencies: comparison of cortical activity in blind and sighted individuals
Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Hum Brain Mapp 31:1686-701. 2010
..However, these data suggest a role in sensory processing for tactile information in blind that parallels a similar contribution for visual stimuli in occipital cortex of sighted...
- The functional properties of barrel cortex neurons projecting to the primary motor cortex
Takashi R Sato
Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA
J Neurosci 30:4256-60. 2010
..Our findings support the view that intermingled neurons in primary sensory areas send specific stimulus features to different parts of the brain...
- Central origin of secondary mechanical hyperalgesia
Department of Physiology and Experimental Pathophysiology, University of Erlangen Nurnberg, 91054 Erlangen, Germany
J Neurophysiol 90:353-9. 2003
..We conclude that the development of allodynia and punctate hyperalgesia in human skin is centrally mediated, whereas the axon reflex vasodilation is of peripheral origin...
- Tactile-auditory shape learning engages the lateral occipital complex
Jung Kyong Kim
Montreal Neurological Institute, McGill University, and Laboratory for Brain, Music, and Sound Research, Montreal, Quebec H3A 2B4, Canada
J Neurosci 31:7848-56. 2011
- Combined contribution of tactile and proprioceptive feedback to hand movement perception
Departement de Neurosciences, Aix Marseille Université CNRS, Laboratoire de Neurobiologie Intégrative et Adaptative UMR 6149, 3 place V Hugo, 13331 Marseille, France
Brain Res 1382:219-29. 2011
..The kinesthetic illusions were copied by the subjects on-line with their left hand...