image enhancement

Summary

Summary: Improvement of the quality of a picture by various techniques, including computer processing, digital filtering, echocardiographic techniques, light and ultrastructural microscopy, fluorescence spectrometry and microscopy, scintigraphy, and in vitro image processing at the molecular level.

Top Publications

  1. ncbi High-resolution maps of magnetization transfer with inherent correction for RF inhomogeneity and T1 relaxation obtained from 3D FLASH MRI
    Gunther Helms
    MR Forschung in der Neurologie und Psychiatrie, Universitatsmedizin Gottingen, Gottingen, Germany
    Magn Reson Med 60:1396-407. 2008
  2. ncbi Mapping complex tissue architecture with diffusion spectrum magnetic resonance imaging
    Van J Wedeen
    Department of Radiology, MGH Martinos Center for Biomedical Imaging, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Magn Reson Med 54:1377-86. 2005
  3. pmc Phase-sensitive inversion recovery for detecting myocardial infarction using gadolinium-delayed hyperenhancement
    Peter Kellman
    Laboratory of Cardiac Energetics, National Institutes of Health, National Heart, Lung and Blood Institute, Bethesda, Maryland 20892 1061, USA
    Magn Reson Med 47:372-83. 2002
  4. ncbi Three-dimensional sub-100 nm resolution fluorescence microscopy of thick samples
    Manuel F Juette
    Institute for Molecular Biophysics, The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Nat Methods 5:527-9. 2008
  5. pmc Ultrahigh speed spectral / Fourier domain OCT ophthalmic imaging at 70,000 to 312,500 axial scans per second
    Benjamin Potsaid
    Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Opt Express 16:15149-69. 2008
  6. pmc Quantification of diffuse myocardial fibrosis and its association with myocardial dysfunction in congenital heart disease
    Craig S Broberg
    Adult Congenital Heart Disease Program, Oregon Health and Science University, Portland, Ore, USA
    Circ Cardiovasc Imaging 3:727-34. 2010
  7. ncbi Distortion correction and robust tensor estimation for MR diffusion imaging
    J F Mangin
    Service Hospitalier Frederic Joliot, CEA, 91401 Orsay, France
    Med Image Anal 6:191-8. 2002
  8. ncbi Detection and characterization of focal liver lesions: a Japanese phase III, multicenter comparison between gadoxetic acid disodium-enhanced magnetic resonance imaging and contrast-enhanced computed tomography predominantly in patients with hepatocellular
    Tomoaki Ichikawa
    Department of Radiology, University of Yamanashi, School of Medicine, Yamanashi, Japan
    Invest Radiol 45:133-41. 2010
  9. ncbi Effects of noise, image resolution, and ROI definition on the accuracy of standard uptake values: a simulation study
    Ronald Boellaard
    PET Center, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Med 45:1519-27. 2004
  10. ncbi Diffusion-weighted MRI in the body: applications and challenges in oncology
    Dow Mu Koh
    Cancer Research UK Clinical Magnetic Resonance Research Group, Institute of Cancer Research, Sutton, Surrey, United Kingdom
    AJR Am J Roentgenol 188:1622-35. 2007

Detail Information

Publications303 found, 100 shown here

  1. ncbi High-resolution maps of magnetization transfer with inherent correction for RF inhomogeneity and T1 relaxation obtained from 3D FLASH MRI
    Gunther Helms
    MR Forschung in der Neurologie und Psychiatrie, Universitatsmedizin Gottingen, Gottingen, Germany
    Magn Reson Med 60:1396-407. 2008
    ..It is inherently compensated for inhomogeneities of receive and transmit RF fields. The MT saturation appeared to be a sensitive parameter to depict MS lesions and alterations of normal-appearing white matter...
  2. ncbi Mapping complex tissue architecture with diffusion spectrum magnetic resonance imaging
    Van J Wedeen
    Department of Radiology, MGH Martinos Center for Biomedical Imaging, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Magn Reson Med 54:1377-86. 2005
    ..Finally, the relation between the presented model-free imaging technique and other available diffusion MRI schemes is discussed...
  3. pmc Phase-sensitive inversion recovery for detecting myocardial infarction using gadolinium-delayed hyperenhancement
    Peter Kellman
    Laboratory of Cardiac Energetics, National Institutes of Health, National Heart, Lung and Blood Institute, Bethesda, Maryland 20892 1061, USA
    Magn Reson Med 47:372-83. 2002
    ..Phase-sensitive detection also has the advantage of decreasing the sensitivity to changes in tissue T(1) with increasing delay from contrast agent injection...
  4. ncbi Three-dimensional sub-100 nm resolution fluorescence microscopy of thick samples
    Manuel F Juette
    Institute for Molecular Biophysics, The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Nat Methods 5:527-9. 2008
    ..This method, named biplane (BP) FPALM, combines a double-plane detection scheme with fluorescence photoactivation localization microscopy (FPALM) enabling 3D sub-diffraction resolution without compromising speed or sensitivity...
  5. pmc Ultrahigh speed spectral / Fourier domain OCT ophthalmic imaging at 70,000 to 312,500 axial scans per second
    Benjamin Potsaid
    Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Opt Express 16:15149-69. 2008
    ....
  6. pmc Quantification of diffuse myocardial fibrosis and its association with myocardial dysfunction in congenital heart disease
    Craig S Broberg
    Adult Congenital Heart Disease Program, Oregon Health and Science University, Portland, Ore, USA
    Circ Cardiovasc Imaging 3:727-34. 2010
    ..the etiology of ventricular dysfunction in adult congenital heart disease (ACHD) is not well understood. Diffuse fibrosis is a likely common final pathway and is quantifiable using MRI...
  7. ncbi Distortion correction and robust tensor estimation for MR diffusion imaging
    J F Mangin
    Service Hospitalier Frederic Joliot, CEA, 91401 Orsay, France
    Med Image Anal 6:191-8. 2002
    ..Several experiments prove that the whole procedure highly improves the quality of the final diffusion maps...
  8. ncbi Detection and characterization of focal liver lesions: a Japanese phase III, multicenter comparison between gadoxetic acid disodium-enhanced magnetic resonance imaging and contrast-enhanced computed tomography predominantly in patients with hepatocellular
    Tomoaki Ichikawa
    Department of Radiology, University of Yamanashi, School of Medicine, Yamanashi, Japan
    Invest Radiol 45:133-41. 2010
    ....
  9. ncbi Effects of noise, image resolution, and ROI definition on the accuracy of standard uptake values: a simulation study
    Ronald Boellaard
    PET Center, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Med 45:1519-27. 2004
    ..Therefore, an experimental and simulation study was performed to determine the effects of noise, image resolution, and region-of-interest (ROI) definition on the accuracy of SUVs...
  10. ncbi Diffusion-weighted MRI in the body: applications and challenges in oncology
    Dow Mu Koh
    Cancer Research UK Clinical Magnetic Resonance Research Group, Institute of Cancer Research, Sutton, Surrey, United Kingdom
    AJR Am J Roentgenol 188:1622-35. 2007
    ..The challenges to widespread adoption of the technique for cancer imaging in the body are discussed...
  11. pmc Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging
    Benjamin J Vakoc
    Wellman Center for Photomedicine, Department of Dermatology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, USA
    Nat Med 15:1219-23. 2009
    ....
  12. ncbi Second-harmonic imaging microscopy for visualizing biomolecular arrays in cells, tissues and organisms
    Paul J Campagnola
    Center for Biomedical Imaging Technology, Department of Physiology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Nat Biotechnol 21:1356-60. 2003
    ..Better dyes and optimized microscope optics could ultimately lead to the imaging of neuronal electrical activity with SHIM...
  13. ncbi Appearance of enhanced tissue features in narrow-band endoscopic imaging
    Kazuhiro Gono
    Olympus Co, Ishikawa cho, Hachioji shi, Tokyo 192 8507, Japan
    J Biomed Opt 9:568-77. 2004
    ..The results of clinical tests in colonoscopy and esophagoscopy indicated that NBI will be useful as a supporting method for observation of the endoscopic findings of early cancer...
  14. ncbi Diffusion weighted whole body imaging with background body signal suppression (DWIBS): technical improvement using free breathing, STIR and high resolution 3D display
    Taro Takahara
    Department of Radiology, Tokai University School of Medicine, Bouseidai, Isehara shi, Kanagawa 259 1193, Japan
    Radiat Med 22:275-82. 2004
    ....
  15. pmc Whole-cell 3D STORM reveals interactions between cellular structures with nanometer-scale resolution
    Bo Huang
    Howard Hughes Medical Institute, Harvard University, 12 Oxford St Cambridge, Massachusetts 02138, USA
    Nat Methods 5:1047-52. 2008
    ..The 3D STORM images resolved mitochondrial morphologies as well as mitochondria-microtubule contacts that were obscured in conventional fluorescence images...
  16. ncbi Manganese-enhanced magnetic resonance imaging (MEMRI): methodological and practical considerations
    Afonso C Silva
    Laboratory of Functional and Molecular Imaging, National Institutes of Neurological Disorders and Stroke, Bethesda, MD 20892 1065, USA
    NMR Biomed 17:532-43. 2004
    ..In the present work the different approaches to MEMRI are reviewed from a practical standpoint. Emphasis is given to the experimental methodology of how to achieve significant, yet safe, amounts of Mn2+ to the target areas of interest...
  17. ncbi Reproducibility of chronic infarct size measurement by contrast-enhanced magnetic resonance imaging
    Heiko Mahrholdt
    Northwestern University Medical School Feinberg Cardiovascular Research Institute, Chicago, Ill, USA
    Circulation 106:2322-7. 2002
    ..The reproducibility of contrast-enhanced MRI has not been established. We compared MRI reproducibility for infarct size determination with that of (99m)Tc-sestamibi (MIBI) single photon emission computed tomography (SPECT)...
  18. ncbi Intravoxel incoherent motion in body diffusion-weighted MRI: reality and challenges
    Dow Mu Koh
    Department of Radiology, Royal Marsden Hospital, Downs Rd, Sutton SM2 5PT, UK
    AJR Am J Roentgenol 196:1351-61. 2011
    ....
  19. pmc An open-source software tool for the generation of relaxation time maps in magnetic resonance imaging
    Daniel R Messroghli
    Cardiac MRI Unit, Franz Volhard Klinik, Charite University Medicine, Berlin, Germany
    BMC Med Imaging 10:16. 2010
    ..Such a software program would allow researchers to test and compare new imaging strategies and thus would significantly facilitate research in the area of quantitative tissue characterization...
  20. ncbi Resolution scaling in STED microscopy
    Benjamin Harke
    Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Gottingen, Germany
    Opt Express 16:4154-62. 2008
    ..For relevant saturation values, the generalized square-root law is shown to predict the practical resolution with high accuracy...
  21. ncbi Tissue classification as a potential approach for attenuation correction in whole-body PET/MRI: evaluation with PET/CT data
    Axel Martínez-Möller
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 50:520-6. 2009
    ..In this study, a potential solution based on a segmented attenuation map is proposed and evaluated in clinical PET/CT cases...
  22. ncbi A multicenter validation of an endoscopic classification with narrow band imaging for gastric precancerous and cancerous lesions
    P Pimentel-Nunes
    Department of Gastroenterology, Portuguese Oncology Institute of Porto, Rua Dr Bernardino de Almeida, Porto, Portugal
    Endoscopy 44:236-46. 2012
    ..The aim of the current study was to describe and estimate the accuracy and reliability of a simplified classification system for NBI in the diagnosis of gastric lesions...
  23. ncbi Textural analysis of contrast-enhanced MR images of the breast
    Peter Gibbs
    Academic Department of Radiology, University of Hull, Hull, United Kingdom
    Magn Reson Med 50:92-8. 2003
    ..On combining features obtained using textural analysis with lesion size, time to maximum enhancement, and patient age, a diagnostic accuracy of A(z) = 0.92 +/- 0.05 was demonstrated...
  24. ncbi Hepatocellular carcinoma: detection with diffusion-weighted versus contrast-enhanced magnetic resonance imaging in pretransplant patients
    Mi Suk Park
    Departments of Radiology, New York University Langone Medical Center, New York, NY, USA
    Hepatology 56:140-8. 2012
    ..0% for DW-set versus 74.0% for CE-set; P = 0.001). The addition of DWI to CET1WI improved sensitivity for the more experienced observer...
  25. ncbi Medical image segmentation by combining graph cuts and oriented active appearance models
    Xinjian Chen
    Department of Radiology and Imaging Sciences, Clinical Center, National Institute of Health, Bethesda, MD 20814, USA
    IEEE Trans Image Process 21:2035-46. 2012
    ..The executable version of the 3-D shape-constrained GC method with a user interface can be downloaded from http://xinjianchen.wordpress.com/research/...
  26. ncbi Diffusion-weighted MRI in renal cell carcinoma: a surrogate marker for predicting nuclear grade and histological subtype
    Ankur Goyal
    Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, India
    Acta Radiol 53:349-58. 2012
    ....
  27. pmc Noninvasive imaging of oral neoplasia with a high-resolution fiber-optic microendoscope
    Timothy J Muldoon
    Rice University Department of Bioengineering, 6100 Main Street, Houston, Texas 77005, USA
    Head Neck 34:305-12. 2012
    ..The purpose of this study was to evaluate the ability of high-resolution microendoscopy to image and quantify changes in cellular and architectural features seen in early oral neoplasia in vivo...
  28. ncbi Liver diffusion-weighted MR imaging: the tower of Babel?
    Boris Guiu
    Eur Radiol 21:463-7. 2011
    ..Here, we review the main principles of DWI of the liver, the limits of the ADC, and the exciting capabilities of multi-parametric DWI. We also insisted on the need for a common language for DWI of the liver...
  29. ncbi Cardiac SSFP imaging at 3 Tesla
    Michael Schar
    Institute for Biomedical Engineering, University of Zurich and Swiss Federal Institute of Technology, Zurich, Switzerland
    Magn Reson Med 51:799-806. 2004
    ..Short-axis, long-axis, and four-chamber cine views obtained in healthy adult subjects are presented, and three different types of artifacts are discussed along with potential methods for reducing them...
  30. ncbi GRAPPA-based susceptibility-weighted imaging of normal volunteers and patients with brain tumor at 7 T
    Janine M Lupo
    Department of Radiology, Surbeck Laboratory of Advanced Imaging, University of California, San Francisco, CA 94158 2532, USA
    Magn Reson Imaging 27:480-8. 2009
    ..GRAPPA-based SWI at 7 T revealed regions of microvascularity, hemorrhage and calcification within heterogeneous brain tumors that may aid in characterizing active or necrotic tumor and monitoring treatment effects...
  31. ncbi Velocity-selective arterial spin labeling
    Eric C Wong
    Department of Radiology, University of California San Diego, La Jolla, 92093, USA
    Magn Reson Med 55:1334-41. 2006
    ..The technical considerations described here include the design of VS pulses, background suppression, anisotropy with respect to velocity-encoding directions, and CBF quantitation issues...
  32. ncbi Optimisation of the 3D MDEFT sequence for anatomical brain imaging: technical implications at 1.5 and 3 T
    R Deichmann
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London WC1N 3BG, UK
    Neuroimage 21:757-67. 2004
    ..It is shown both theoretically and experimentally that these problems can be avoided by using spin tagging and fat saturation...
  33. ncbi Ultrasound contrast imaging research
    Michalakis Averkiou
    Philips Medical Systems Philips Ultrasound, Bothell, Washington 98041 3003, USA
    Ultrasound Q 19:27-37. 2003
    ..A connection is made between the aforementioned imaging techniques and the different contrast agents available. The blood flow appearance of different liver tumors in the presence of contrast agents is demonstrated with examples...
  34. ncbi CT substitute derived from MRI sequences with ultrashort echo time
    Adam Johansson
    Department of Radiation Sciences, Umea University, Umea, Sweden
    Med Phys 38:2708-14. 2011
    ..This study presents a method for generating a drop in substitute for a CT image from a set of magnetic resonance (MR)images...
  35. ncbi In vivo biochemical 7.0 Tesla magnetic resonance: preliminary results of dGEMRIC, zonal T2, and T2* mapping of articular cartilage
    Goetz H Welsch
    MR Center, Department of Radiology, Medical University of Vienna, Vienna, Austria
    Invest Radiol 43:619-26. 2008
    ..0 T MRI; and to evaluate the potential of T2 and T2* measurements in an initial patient study after matrix-associated autologous chondrocyte transplantation (MACT) in the knee...
  36. ncbi Diffusion tensor MRI: preliminary anisotropy measures and mapping of breast tumors
    Savannah C Partridge
    Department of Radiology, University of Washington, Seattle, Washington, USA
    J Magn Reson Imaging 31:339-47. 2010
    ..To investigate whether diffusion tensor imaging (DTI) measures of anisotropy in breast tumors are different from normal breast tissue and can improve the discrimination between benign and malignant lesions...
  37. pmc Improved arterial spin labeling after myocardial infarction in mice using cardiac and respiratory gated look-locker imaging with fuzzy C-means clustering
    Moriel H Vandsburger
    Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA
    Magn Reson Med 63:648-57. 2010
    ..This technique, when applied to genetically engineered mice, will allow for the investigation of the roles of specific genes in myocardial perfusion during infarct healing...
  38. ncbi Circumferential and longitudinal strain in 3 myocardial layers in normal subjects and in patients with regional left ventricular dysfunction
    Marina Leitman
    Department of Cardiology, Assaf Harofeh Medical Center, Zerifin, Israel
    J Am Soc Echocardiogr 23:64-70. 2010
    ..The aim of this study was to analyze strain in 3 myocardial layers using speckle-tracking echocardiography...
  39. ncbi Diffusion-weighted imaging of normal fibroglandular breast tissue: influence of microperfusion and fat suppression technique on the apparent diffusion coefficient
    Paul Baron
    University Medical Center Groningen, Department of Radiology, Groningen, The Netherlands
    NMR Biomed 23:399-405. 2010
    ..These factors may be crucial in the differentiation between benign and malignant lesions...
  40. ncbi Automatic segmentation of the prostate in 3D MR images by atlas matching using localized mutual information
    Stefan Klein
    Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    Med Phys 35:1407-17. 2008
    ..87. The segmentation quality is especially good at the prostate-rectum interface, where the segmentation error remains below 1 mm in 50% of the cases and below 1.5 mm in 75% of the cases...
  41. ncbi Two-dimensional PCA: a new approach to appearance-based face representation and recognition
    Jian Yang
    Department of Computing, Hong Kong Polytechnic University, Kowloon, Hong Kong
    IEEE Trans Pattern Anal Mach Intell 26:131-7. 2004
    ..The recognition rate across all trials was higher using 2DPCA than PCA. The experimental results also indicated that the extraction of image features is computationally more efficient using 2DPCA than PCA...
  42. pmc Topological FDR for neuroimaging
    J Chumbley
    Wellcome Trust Centre for Neuroimaging, London, UK
    Neuroimage 49:3057-64. 2010
    ..Finally, we present an illustrative application using an fMRI study of visual attention...
  43. ncbi Optimization of b-value sampling for diffusion-weighted imaging of the kidney
    Jeff L Zhang
    Department of Radiology, New York University, New York, New York, USA
    Magn Reson Med 67:89-97. 2012
    ..In conclusion, the proposed method has the potential of maximizing the precision and accuracy of the biexponential analysis of renal DWI...
  44. ncbi Orthogonal laplacianfaces for face recognition
    Deng Cai
    IEEE Trans Image Process 15:3608-14. 2006
    ..Experimental results on three face databases demonstrate the effectiveness of our proposed algorithm...
  45. ncbi Diffusion-weighted MR imaging in the evaluation of renal infection: preliminary results
    G Verswijvel
    Department of Radiology, Ziekenhuis Oost Limburg ZOL, Genk, Belgium
    JBR-BTR 85:100-3. 2002
    ..This manuscripts shows preliminary findings of DW imaging in patients with renal infectious disease...
  46. pmc Optimal k-space sampling for dynamic contrast-enhanced MRI with an application to MR renography
    Ting Song
    Department of Radiology, New York University School of Medicine, New York, New York 10016, USA
    Magn Reson Med 61:1242-8. 2009
    ..4 sec temporal resolution. The proposed method can be generalized to other dynamic contrast-enhanced MRI applications, e.g., MR angiography or cancer imaging...
  47. ncbi Quantification of renal perfusion: comparison of arterial spin labeling and dynamic contrast-enhanced MRI
    Jeff D Winter
    Research Institute, Diagnostic Imaging, Hospital for Sick Children, Toronto, Canada
    J Magn Reson Imaging 34:608-15. 2011
    ..Moreover, we provide the first application of the dual bolus approach to quantitative DCE-MRI perfusion measurements in the kidney...
  48. ncbi High-resolution T1 and T2 mapping of the brain in a clinically acceptable time with DESPOT1 and DESPOT2
    Sean C L Deoni
    Imaging Research Laboratories, Robarts Research Institute, 100 Perth Drive, London, Ontario, Canada N6A 5K8
    Magn Reson Med 53:237-41. 2005
    ..7 ms and 6.7 ms. These results demonstrate the clinical feasibility of the methods in the study of neurologic disease...
  49. pmc Improved diagnostic accuracy of breast MRI through combined apparent diffusion coefficients and dynamic contrast-enhanced kinetics
    S C Partridge
    Department of Radiology, University of Washington, Seattle, Washington 98109 1023, USA
    Magn Reson Med 65:1759-67. 2011
    ..85 and 0.78 with 5-fold cross validation)...
  50. ncbi Segmentation and tracking of migrating cells in videomicroscopy with parametric active contours: a tool for cell-based drug testing
    Christophe Zimmer
    Quantitative Image Analysis Unit, Institut Pasteur, and also with the CNRS UMR 1947, 75724 Paris, France
    IEEE Trans Med Imaging 21:1212-21. 2002
    ..Our tracking technique was validated on a realistic data set by comparison with a manually defined ground-truth and was successfully applied to study the motility of amoebae in a biological research project...
  51. pmc Carotid plaque assessment using fast 3D isotropic resolution black-blood MRI
    Niranjan Balu
    Department of Radiology, University of Washington, Seattle, Washington 98019, USA
    Magn Reson Med 65:627-37. 2011
    ..3D-MERGE is a promising new tool for fast and accurate plaque burden assessment in patients with atherosclerotic plaque...
  52. ncbi A new supervised method for blood vessel segmentation in retinal images by using gray-level and moment invariants-based features
    Diego Marin
    Department of Electronic, Computer Science and Automatic Engineering, La Rábida Polytechnic School, University of Huelva, 21819 Palos de Frontera, Spain
    IEEE Trans Med Imaging 30:146-58. 2011
    ....
  53. ncbi A general framework for the analysis of vessel encoded arterial spin labeling for vascular territory mapping
    Michael A Chappell
    Oxford Centre for Functional MRI of the Brain, University of Oxford, John Radcliffe Hospital, Headington, Oxford, United Kingdom
    Magn Reson Med 64:1529-39. 2010
    ..Similar performance was found for data acquired using a pseudo-continuous labeling scheme both in the neck and above the Circle of Willis...
  54. ncbi fMRI at 1.5, 3 and 7 T: characterising BOLD signal changes
    Wietske van der Zwaag
    Sir Peter Mansfield Magnetic Resonance Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, UK
    Neuroimage 47:1425-34. 2009
    ..An earlier onset of the haemodynamic response at higher field provides some evidence for a reduced venous contribution to the BOLD signal at 7 T...
  55. ncbi Microstrip RF surface coil design for extremely high-field MRI and spectroscopy
    X Zhang
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota School of Medicine, Minneapolis, Minnesota 55455, USA
    Magn Reson Med 46:443-50. 2001
    ..The results reveal that the novel surface coil design based on the microstrip concept makes very high-field MRI/MRS more convenient and efficient in research and future clinics...
  56. ncbi Added value and diagnostic performance of intratumoral susceptibility signals in the differential diagnosis of solitary enhancing brain lesions: preliminary study
    H S Kim
    Department of Diagnostic Radiology, Ajou University School of Medicine, Suwon, Korea
    AJNR Am J Neuroradiol 30:1574-9. 2009
    ..The purpose of this study was to determine the added value and diagnostic performance of HR-SWI for differentiating solitary enhancing brain lesions (SELs) by assessing intratumoral susceptibility signals (ITSSs)...
  57. ncbi New proposal for the staging of nonalcoholic steatohepatitis: evaluation of liver fibrosis on Gd-EOB-DTPA-enhanced MRI
    Natsuko Tsuda
    Medical Affairs Diagnostic Imaging, Medical Affairs, Bayer Yakuhin, Ltd 2 4 9, Umeda, Kita ku, Osaka 530 0001, Japan
    Eur J Radiol 73:137-42. 2010
    ..We investigated whether the gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MRI was useful for nonalcoholic steatohepatitis (NASH) staging based on the severity of liver fibrosis...
  58. ncbi Retinal vessel segmentation using the 2-D Gabor wavelet and supervised classification
    João V B Soares
    Institute of Mathematics and Statistics, University of Sao Paulo, 05508 090 Brazil
    IEEE Trans Med Imaging 25:1214-22. 2006
    ..We are making our implementation available as open source MATLAB scripts for researchers interested in implementation details, evaluation, or development of methods...
  59. pmc Non-diffeomorphic registration of brain tumor images by simulating tissue loss and tumor growth
    Evangelia I Zacharaki
    Section of Biomedical Image Analysis, University of Pennsylvania, Philadelphia, PA, USA
    Neuroimage 46:762-74. 2009
    ....
  60. pmc An optimized blockwise nonlocal means denoising filter for 3-D magnetic resonance images
    P Coupe
    University of Rennes, I CNRSUMR6074, IRISA, F 35042 Rennes, France
    IEEE Trans Med Imaging 27:425-41. 2008
    ..1992) in terms of accuracy (measured by the peak signal-to-noise ratio) with low computation time. Finally, qualitative results on real data are presented ...
  61. ncbi Assessment of diffuse myocardial fibrosis in rats using small-animal Look-Locker inversion recovery T1 mapping
    Daniel R Messroghli
    Department of Congenital Heart Disease and Pediatric Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany
    Circ Cardiovasc Imaging 4:636-40. 2011
    ..We hypothesized that diffuse myocardial fibrosis in a small-animal model could be quantitatively assessed by measuring myocardial ECV using small-animal Look-Locker inversion recovery T1 mapping...
  62. ncbi Improved visibility of lesions of the small intestine via capsule endoscopy with computed virtual chromoendoscopy
    Hiroki Imagawa
    Department of Medicine and Molecular Science, Graduate School of Biomedical Science, Hiroshima University, and Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan
    Gastrointest Endosc 73:299-306. 2011
    ..We can now enhance video capsule endoscopy (CE) images in real time by means of a flexible spectral imaging color enhancement (FICE) digital processing system. Reports on the clinical usefulness of this system are few...
  63. ncbi Normalized cuts in 3-D for spinal MRI segmentation
    Julio Carballido-Gamio
    Joint Graduate Group in Bioengineering, University of California, San Francisco, 94143 1290, USA
    IEEE Trans Med Imaging 23:36-44. 2004
    ..Results of the segmentation as well as limitations and challenges in this area are presented...
  64. pmc Impact of [¹⁸F]FDG PET imaging parameters on automatic tumour delineation: need for improved tumour delineation methodology
    Patsuree Cheebsumon
    Department of Nuclear Medicine and PET Research, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 38:2136-44. 2011
    ..e. reconstruction parameters, noise levels and tumour characteristics, and thereby the need for standardization or inter-institute calibration...
  65. ncbi Contrast-enhanced ultrasound (CEUS) for the characterization of focal liver lesions in clinical practice (DEGUM Multicenter Trial): CEUS vs. MRI--a prospective comparison in 269 patients
    K Seitz
    Department of Internal Medicine, District Hospital Sigmaringen, Sigmaringen, Germany
    Ultraschall Med 31:492-9. 2010
    ..One important aspect is the comparison of CEUS with magnetic resonance imaging (MRI)...
  66. ncbi A fuzzy, nonparametric segmentation framework for DTI and MRI analysis: with applications to DTI-tract extraction
    Suyash P Awate
    Penn Image Computing and Science Laboratory PICSL, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104 USA
    IEEE Trans Med Imaging 26:1525-36. 2007
    ..The results demonstrate that the proposed method extracts this structure significantly more accurately as compared to tractography...
  67. ncbi Principles of diffusion tensor imaging and its applications to basic neuroscience research
    Susumu Mori
    Department of Radiology, Division of NMR, Johns Hopkins University, School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Neuron 51:527-39. 2006
    ..The strengths and limitations of DTI and key areas for future research and development are also discussed...
  68. ncbi Delayed enhancement magnetic resonance imaging predicts response to cardiac resynchronization therapy in patients with intraventricular dyssynchrony
    James A White
    Division of Cardiology, Department of Medicine, University of Western Ontario, London, Ontario, Canada
    J Am Coll Cardiol 48:1953-60. 2006
    ..We evaluated the ability of delayed enhancement magnetic resonance imaging (DE-MRI) to predict clinical response to cardiac resynchronization therapy (CRT)...
  69. ncbi Contrast-enhanced MR cholangiography with Gd-EOB-DTPA in patients with liver cirrhosis: visualization of the biliary ducts in comparison with patients with normal liver parenchyma
    Frank T C Tschirch
    Institute of Diagnostic Radiology, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    Eur Radiol 18:1577-86. 2008
    ..Consecutively, EOB-MRC in patients with liver cirrhosis resulted in a decreased or even non-visualization of the biliary tree in a substantial percentage of patients...
  70. ncbi The architecture of active zone material at the frog's neuromuscular junction
    M L Harlow
    Department of Neurobiology, Stanford University School of Medicine, California 94305, USA
    Nature 409:479-84. 2001
    ..The structural linkage may include proteins that mediate the calcium-triggered exocytosis of neurotransmitter by the synaptic vesicles during synaptic transmission...
  71. ncbi Gaussian approximations of fluorescence microscope point-spread function models
    Bo Zhang
    Unité d Analyse d Images Quantitative, Institut Pasteur, Cedex, France
    Appl Opt 46:1819-29. 2007
    ..All the Gaussian parameters derived in this study are in explicit analytical form, allowing their direct use in practical applications...
  72. ncbi Computing average shaped tissue probability templates
    John Ashburner
    Wellcome Trust Centre for Neuroimaging, 12 Queen Square, London, WC1N 3BG, UK
    Neuroimage 45:333-41. 2009
    ..g. grey and white matter) are registered simultaneously with the current template estimate. In order to generalise the resulting template to a broader range of subjects, a template blurriness prior is included within the model...
  73. ncbi Volumetric texture analysis of breast lesions on contrast-enhanced magnetic resonance images
    Weijie Chen
    Department of Radiology, Committee on Medical Physics, The University of Chicago, Chicago, Illinois 60637, USA
    Magn Reson Med 58:562-71. 2007
    ..Our investigations of the effects of various of parameters on the diagnostic accuracy provided means for the optimal use of the approach...
  74. ncbi Nonenhanced MR angiography
    Mitsue Miyazaki
    Department of MRI, Toshiba Medical Research Institute USA, 990 Corporate Woods Pkwy, Vernon Hills, IL 60061, USA
    Radiology 248:20-43. 2008
    ..Developments on the horizon include techniques that provide time-resolved imaging for assessment of flow dynamics by using nonenhanced approaches...
  75. ncbi Novel imaging techniques for diffuse myocardial fibrosis
    Daniel M Sado
    Department of Inherited Cardiac Disease, The Heart Hospital, 16 18 Westmoreland Street, London, W1G 8PH, UK
    Future Cardiol 7:643-50. 2011
    ..This review explores the basic biology of DMF and then discusses the ability of various cardiac imaging modalities to evaluate this variable, speculating on how this area of research may develop over the next few years...
  76. ncbi Segmentation of retinal blood vessels by combining the detection of centerlines and morphological reconstruction
    Ana Maria Mendonça
    Signal and Image Laboratory, Institute for Biomedical Engineering, University of Porto, Campus da FEUP DEEC, 4200 465 Porto, Portugal
    IEEE Trans Med Imaging 25:1200-13. 2006
    ..The results demonstrate that our algorithm outperforms other solutions and approximates the average accuracy of a human observer without a significant degradation of sensitivity and specificity...
  77. ncbi Probabilistic Monte Carlo based mapping of cerebral connections utilising whole-brain crossing fibre information
    Geoff J M Parker
    Imaging Science and Biomedical Engineering, University of Manchester, Manchester M13 9PT, UK
    Inf Process Med Imaging 18:684-95. 2003
    ..This information is used for standard and Monte Carlo streamline methods. Deterministic and probabilistic maps of anatomical voxel scale connectivity between brain regions are generated...
  78. ncbi Iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL): application with fast spin-echo imaging
    Scott B Reeder
    Department of Radiology, Stanford University Medical Center, Stanford, California, USA
    Magn Reson Med 54:636-44. 2005
    ..Close agreement between theoretical and experimental results obtained from an oil-water phantom was observed, demonstrating that the iterative least-squares decomposition method is an efficient estimator...
  79. pmc Imaging three-dimensional myocardial mechanics using navigator-gated volumetric spiral cine DENSE MRI
    Xiaodong Zhong
    Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA
    Magn Reson Med 64:1089-97. 2010
    ..Also, the 3D strains, twist, and torsion results obtained by 3D cine DENSE were in good agreement with historical values measured by 3D myocardial tagging...
  80. ncbi Two-dimensional strain--a Doppler-independent ultrasound method for quantitation of regional deformation: validation in vitro and in vivo
    Josef Korinek
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    J Am Soc Echocardiogr 18:1247-53. 2005
    ..We compared strains measured in vitro and in vivo by 2DSE with those obtained by sonomicrometry...
  81. ncbi Narrow band imaging with magnification for the characterization of small and diminutive colonic polyps: pit pattern and vascular pattern intensity
    J E East
    Wolfson Unit for Endoscopy, St Mark s Hospital, Imperial College London, London, UK
    Endoscopy 40:811-7. 2008
    ..We aimed to assess whether the Kudo pit pattern classification is accurate when used with NBI (without dye-spray), and if microvascular appearances or NBI pit patterns maintain accuracy for polyp characterization at sizes < 10 mm...
  82. ncbi Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) in early knee osteoarthritis
    Carl Johan Tiderius
    Department of Orthopedics, Diagnostic Radiology and Radiation Physics, Malmo University Hospital, Lund University, Sweden
    Magn Reson Med 49:488-92. 2003
    ..5 than at 3 hr in the diseased but not in the reference compartment. In conclusion, dGEMRIC can identify GAG loss in early stage cartilage disease with a higher sensitivity at 1.5 than 3 hr...
  83. ncbi Diffusion tensor MR imaging and fiber tractography: technical considerations
    P Mukherjee
    Department of Radiology, University of California, San Francisco, San Francisco, CA 94143 0628, USA
    AJNR Am J Neuroradiol 29:843-52. 2008
    ..An overview of current methods for quantitative analysis of DTI data and fiber tractography in clinical research is also provided...
  84. ncbi On the nature of the BOLD fMRI contrast mechanism
    Nikos K Logothetis
    Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Spemannstrasse 38, 72076 Tubingen, Germany
    Magn Reson Imaging 22:1517-31. 2004
    ..We conclude by considering applications of invasive MRI, including injections of paramagnetic tracers for the study of connectivity in the living animal and simultaneous imaging and electrical microstimulation...
  85. ncbi Anatomically constrained region deformation for the automated segmentation of the hippocampus and the amygdala: Method and validation on controls and patients with Alzheimer's disease
    Marie Chupin
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, UCL, UK
    Neuroimage 34:996-1019. 2007
    ..The proposed approach provides a new framework for further developments in quantitative analyses of the pathological hippocampus and amygdala in MRI scans...
  86. pmc Retinal pigment epithelium segmentation by polarization sensitive optical coherence tomography
    Erich Gotzinger
    Center for Biomedical Engineering and Physics, Medical University of Vienna, Austria
    Opt Express 16:16410-22. 2008
    ..By using a state of the art spectral domain PS-OCT instrument, we demonstrate the method in healthy and diseased eyes...
  87. ncbi Cell refractive index tomography by digital holographic microscopy
    Florian Charrière
    Ecole Polytechnique Federale de Lausanne, Imaging and Applied Optics Institute, Switzerland
    Opt Lett 31:178-80. 2006
    ..A precision of 0.01 for the refractive index estimation and a spatial resolution in the micrometer range are demonstrated...
  88. ncbi BOLD contrast sensitivity enhancement and artifact reduction with multiecho EPI: parallel-acquired inhomogeneity-desensitized fMRI
    Benedikt A Poser
    FC Donders Centre for Cognitive Neuroimaging, Nijmegen, The Netherlands
    Magn Reson Med 55:1227-35. 2006
    ..The use of parallel imaging markedly reduces image distortion, and hence the method should find widespread application in functional brain imaging...
  89. ncbi Functional MR imaging of prostate cancer
    Young Jun Choi
    Department of Radiology, Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, 388 1 Poong nap dong, Songpa Gu, Seoul 138 736, South Korea
    Radiographics 27:63-75; discussion 75-7. 2007
    ....
  90. pmc Minimization of region-scalable fitting energy for image segmentation
    Chunming Li
    Institute of Imaging Science, Vanderbilt University, Nashville, TN 37232, USA
    IEEE Trans Image Process 17:1940-9. 2008
    ..Experimental results for synthetic and real images show desirable performances of our method...
  91. pmc Polarization maintaining fiber based ultra-high resolution spectral domain polarization sensitive optical coherence tomography
    Erich Gotzinger
    Center for Biomedical Engineering and Physics, Medical University of Vienna, Austria
    Opt Express 17:22704-17. 2009
    ..The latter is important for improved resolution of depolarization imaging. We demonstrate our instrument for high-resolution PS-OCT imaging of the healthy human retina...
  92. ncbi In vivo assessment of tumoral angiogenesis
    I Tropres
    Unité mixte INSERM 594 Université Joseph Fourier, Laboratoire de Recherche Conventionné du CEA No 30V, Hopital Albert Michallon, and European Synchrotron Radiation Facility, Grenoble, France
    Magn Reson Med 51:533-41. 2004
    ..74) between VSIhisto and VSIMRI with a linear regression coefficient of 1.17. The good correlation coefficient supports VSI imaging as a quantitative method for tumor vasculature characterization...
  93. ncbi Susceptibility weighted imaging at ultra high magnetic field strengths: theoretical considerations and experimental results
    Andreas Deistung
    Medical Physics Group, Institute for Diagnostic and Interventional Radiology, University Clinics, Friedrich Schiller University, Jena, Germany
    Magn Reson Med 60:1155-68. 2008
    ....
  94. ncbi Quantitative 2D and 3D phase contrast MRI: optimized analysis of blood flow and vessel wall parameters
    A F Stalder
    Department of Diagnostic Radiology, Medical Physics, University Hospital Freiburg, Freiburg, Germany
    Magn Reson Med 60:1218-31. 2008
    ..Initial results in a patient with atherosclerosis suggest the potential of the method for understanding the formation and progression of cardiovascular diseases...
  95. pmc The role of diffusion-weighted imaging and the apparent diffusion coefficient (ADC) values for breast tumors
    Mi Jung Park
    Department of Radiology, St Vincent s Hospital, The Catholic University of Korea, Suwon, Korea
    Korean J Radiol 8:390-6. 2007
    ..We wanted to evaluate the role of diffusion-weighted imaging (DWI) and the apparent diffusion coefficient (ADC) for detecting breast tumors, as compared with the T1- and T2-weighted images...
  96. ncbi Accuracy of fluorescent tomography in the presence of heterogeneities: study of the normalized Born ratio
    Antoine Soubret
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    IEEE Trans Med Imaging 24:1377-86. 2005
    ..Findings are further contrasted to images obtained with the standard Born expansion and with a normalized approach that divides the fluorescent field with excitation measurements through a homogeneous medium...
  97. ncbi The salvaged area at risk in reperfused acute myocardial infarction as visualized by cardiovascular magnetic resonance
    Matthias G Friedrich
    Stephenson Cardiovascular Magnetic Resonance Centre at the Libin Cardiovascular Institute of Alberta, Department of Cardiac Sciences, University of Calgary, Alberta, Canada
    J Am Coll Cardiol 51:1581-7. 2008
    ..We aimed to characterize the tissue changes within the perfusion bed of infarct-related vessels in patients with acutely reperfused myocardial infarction (MI) using cardiovascular magnetic resonance (CMR)...
  98. pmc Reliability of MRI-derived cortical and subcortical morphometric measures: effects of pulse sequence, voxel geometry, and parallel imaging
    J S Wonderlick
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuroimage 44:1324-33. 2009
    ..These results suggest that these improvements in MRI acquisition technology do not compromise data reproducibility, but that consistency should be maintained in choosing imaging parameters for structural MRI studies...
  99. ncbi STED with wavelengths closer to the emission maximum
    Giuseppe Vicidomini
    Department of NanoBiophotonics, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Gottingen, Germany
    Opt Express 20:5225-36. 2012
    ..The method is exemplified by imaging immunolabeled features in mammalian cells with an up to 3-fold increased STED efficiency compared to that encountered in standard STED nanoscopy implementations...
  100. ncbi PET-MRI fusion in head-and-neck oncology: current status and implications for hybrid PET/MRI
    Denys J Loeffelbein
    Department of Oral and Maxillofacial Surgery, Technische Universitat Munchen, Munchen, Germany
    J Oral Maxillofac Surg 70:473-83. 2012
    ..To review the current status and clinical effect of PET-MRI image fusion in the staging of head-and-neck cancer and to show its implications for imaging with future hybrid PET/MRI scanners...
  101. pmc High-resolution magnetic resonance imaging quantitatively detects individual pancreatic islets
    Smaragda Lamprianou
    Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland
    Diabetes 60:2853-60. 2011
    ..We studied whether manganese-enhanced high-field magnetic resonance (MR) imaging (MEHFMRI) could quantitatively detect individual islets in situ and in vivo and evaluate changes in a model of experimental diabetes...

Research Grants62

  1. aSi/CsI FP digital chest imaging with scatter rejection
    Chris Shaw; Fiscal Year: 2005
    ..study to compare the scanning equalization DR chest images with regular DR images with and without digital image enhancement processing...
  2. Noninvasive Functional and Cellular Imaging of Epilepsy
    Huabei Jiang; Fiscal Year: 2013
    ..and test a fast multispectral optical system for functional/cellular DOT imaging;(2) To develop a set of image enhancement schemes for improved DOT imaging of small animals, and To develop both linear and nonlinear models that ..
  3. Significant static &dynamic structures in natural scenes for visual recognition
    Jozsef Fiser; Fiscal Year: 2011
    ..directly applied to two visually-impaired populations with the overall goal of informing the development of image enhancement techniques, effective low cost visual aids and visual training strategies to maximize visual function in ..
  4. Modular Ultrasonic Beacon System (MUBS) for Ultrasound-guided Interventional Surg
    Jay Mung; Fiscal Year: 2013
    ..These applications extend to nerve block and line-placement, beyond image enhancement to imaging, tissue characterization, monitoring and therapy.
  5. Image Enhancement and Segmentation for Deep Tissue Microscopy
    Paul Salama; Fiscal Year: 2010
    ....
  6. Driving Simulator for Vision Research
    Eli Peli; Fiscal Year: 2010
    ..eye and head movement behaviors of drivers with vision impairment, and whether optical visual aids and image enhancement techniques can improve specific aspects of their driving performance...
  7. PHRENIC NERVE PACING: NONINVASIVE DIAPHRAGM ANALYSIS
    Sidney Levitsky; Fiscal Year: 1980
    ..to be well-suited for complete digitization of the television picture for the facilitation of diaphragm image enhancement techniques...
  8. Low-dose Myocardial Perfusion Imaging by CT
    Adam M Alessio; Fiscal Year: 2013
    ..This work proposes novel low-dose acquisition and data/image enhancement strategies to enable accurate quantitative estimates of blood flow in absolute units of ml/g/min...
  9. MODEL-BASED IMAGE ENHANCEMENT FOR THE VISUALLY IMPAIRED
    Eli Peli; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The long-term goal of this project is to design and evaluate practical image enhancement methods that would enable people with impaired vision, particularly those with central field loss due to age-..
  10. Pressure Ulcer Detection in Darkly Pigmented Skin
    Robin Felder; Fiscal Year: 2007
    ..g., red/green) and narrow-band visible imaging when coupled with image enhancement, even in the darkest skin tones...
  11. DETECTION OF OSTEOPOROSIS USING DENTAL RADIOGRAPHS
    KARIN SOUTHARD; Fiscal Year: 1992
    ..Digital image enhancement processing of the profiles will be studied followed by an exhaustive application of image feature extraction ..
  12. GUIDANCE OF MOTONEURON GROWTH CONES
    Kathryn Tosney; Fiscal Year: 1991
    ..are labeled with a non-toxin fluorescent dye that allows visualization of active growth cones with image enhancement technology...
  13. Enhancement of Dynamic Media for Visually-Impaired People
    PETER JOHN BEX; Fiscal Year: 2012
    ..These approaches are brought together in a novel, low cost image enhancement system that will operate on standard computers...
  14. ENERGY RESOLVED DIGITAL HPGE X OR Y-RAY IMAGING DETECTOR
    William Warburton; Fiscal Year: 2001
    ..Digital output is particularly useful since it allows image enhancement, analysis, transmission and storage...
  15. ANGIOGRAPHIC IMAGING OF CORONARY LESION MORPHOLOGY
    James Whiting; Fiscal Year: 1992
    ..to define the accuracy of morphological classification of coronary stenoses and how accuracy depends upon image enhancement and display; (3) to develop imaging and display techniques for maximizing this accuracy; and (4) to perform ..
  16. LOW VISION AID FOR OBSERVERS WITH CENTRAL VISION LOSSES
    TERI LAWTON; Fiscal Year: 1991
    ..device to help visually impaired persons maximize the use of their residual vision, using innovative image enhancement filters that will be available commercially as an option on current closed-circuit TV (CCTV) readers...
  17. AIDS AS A CAUSE FOR PRIMARY OPTIC NEUROPATHY
    Alfredo Sadun; Fiscal Year: 1991
    ..Additionally, the PPD method in conjunction with our computerized image enhancement system permits us to do quantitative analyses of total fiber counts, and the nerve fiber spectrum...
  18. Optimazed Quenched NIRF Probes for Optical Imaging
    Ronald Cook; Fiscal Year: 2004
    ..In a number of recent research reports, these agents have been shown to have remarkable value for selective image enhancement of tissues, and potentially for viewing biochemical events in the cell (Molecular Imaging)...
  19. NEW ALGORITHMS FOR HIGH RESOLUTION EIT
    DAVID MACENANY; Fiscal Year: 1992
    ..The proposed research aims at implementing numerical algorithms based on this formula and also employing new nonlinear image enhancement algorithms which yield optimal noise-reduction parametrized by resolution.
  20. MINORITY HIGH SCHOOL STUDENT RESEARCH APPRENTICE PROGRAM
    WILMA SAFFRAN; Fiscal Year: 1993
    ..The image enhancement capabilities of the IVS Image I system will be necessary to resolve small changes in hair cell length, while ..
  21. BIOEFFECTS OF GAS BODY ACTIVATION IN MEDICAL ULTRASOUND
    Douglas Miller; Fiscal Year: 2001
    ..bioeffects? Theoretical analysis and physical experiments will determine the relationships between the image enhancement process, gas body destabilization and bioeffects mechanisms. 2...
  22. MICROWAVE IMAGING FOR THERAPY MONITORING AND ASSESSMENT
    Keith Paulsen; Fiscal Year: 2001
    ..of a suite of three- dimensional image reconstruction algorithms which include the 3D analogs of the 2D image enhancement methods of dual meshing and total variation minimization, (3) evaluation and optimization of 3D microwave ..
  23. A 2048X2048 PIXEL CCD X-RAY IMAGE SENSOR SYSTEM
    A Cope; Fiscal Year: 1990
    ..and the camera will be designed to produce 16 bit per pixel digital video suitable for computer processing y image enhancement software and equipment...
  24. Superior Medical Scintillators by Vapor Deposition
    VINOD SARIN; Fiscal Year: 2007
    ..This will for the first time make the benefits of digital techniques in data management, image enhancement, and differential analysis widely available to the broad medical radiological community...
  25. Retinal Image Enhancement based on the Human Visual System
    Kamel Belkacem Boussaid; Fiscal Year: 2007
    ..The project will show that improvement can be realized for any existing fundus camera, thereby opening up the market to all future and existing instruments. ..
  26. NOVEL MINIMALLY INVASIVE METHOD TO IDENTIFY LUNG MALIGNANCIES BY MRI
    ANDREAS MUEHLER; Fiscal Year: 2006
    ..This proposal, in response to PA-04-094, proposes a strategy to optimize this novel in vivo image enhancement method to help diagnose lung cancer...
  27. LOW X-RAY DOSE DIGITAL MAMMOGRAPHY SYSTEM
    STEPHEN GAALEMA; Fiscal Year: 1993
    ..array is ideally suited for Computed Radiology including: electronic archiving and image transmission, image enhancement and analysis, and computer aided diagnosis...
  28. ENGINEERING APPROACHES TO LOW VISION REHABILITATION
    Eli Peli; Fiscal Year: 2005
    ..The three engineering approaches that we will explore are multiplexing dynamic control of display, and image enhancement. Also, we show that various combinations of these approaches are possible and likely to be beneficial...
  29. IRON CHELATES FOR CONTRAST ENHANCEMENT IN NMR IMAGING
    Barry Engelstad; Fiscal Year: 1990
    ..Practical agents for image enhancement in several organ systems will be introduced...
  30. TUMOR CELL PURGING USING FLUORESCENT ANTIBODIES
    ELIE HANANIA; Fiscal Year: 2000
    ..Fluorescent detection of tumor cells will be optimized using image enhancement software algorithms with a high performance cooled-CCD camera...
  31. SCINTILLATOR FOR HIGH RESOLUTION MAMMOGRAPHY
    Vivek Nagarkar; Fiscal Year: 2000
    ..film-screen, while the digital nature of the image would permit a wide dynamic range and the possibility of image enhancement. PROPOSED COMMERCIAL APPLICATION In addition to the enormous clinical x-ray imaging market, the proposed ..
  32. RETROVIRUS STRUCTURAL PROTEIN INTERACTIONS
    Eric Barklis; Fiscal Year: 2001
    ..Arrays will be analyzed to define Gag and RNA interactions by image enhancement-electron diffraction methods...
  33. DIAGNOSIS OF INTRACRANIAL DISEASE
    FRANCIS FRY; Fiscal Year: 1980
    ..This circumstance has been proven both in vitro and in vivo. These facts, along with signal processing and image enhancement schemes, will be used to design and construct a clinical ultrasonic system for the diagnosis of intracranial ..
  34. LASER SCANNING CONFOCAL MICROSCOPE WITH IMAGE PROCESSING
    Richard Altschuler; Fiscal Year: 1990
    ..Construction of 3-D images from optical sectioning and interactive tilting, rotating, slicing, and image enhancement is possible with an appropriately powerful computer workstation...
  35. Radiological Image Enhancement with Tantalum, a Heavy Z Atom
    MARC SCHRIER; Fiscal Year: 2008
    ..They can also provide better imaging for obese patients and an alternative contrast agent for patients allergic to iodine. [unreadable] [unreadable] [unreadable]..
  36. IMPROVING CRT DISPLAY OF DIGITAL MAMMOGRAMS
    Hans Roehrig; Fiscal Year: 2002
    ..Using our CRT evaluation system we will evaluate the image quality of the CRTs to be used for the project in order to find the MTF and other pertinent information for the image enhancement.
  37. Spectral-Encoding for Video-Rate Hemodynamic Tomography
    Brian Pogue; Fiscal Year: 2007
    ..abstract_text> ..
  38. Quantitative mapping of the intervertebral disc
    Walter Witschey; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  39. 3T Atherosclerotic MRI and Carotid Artery Scoring System
    Chun Yuan; Fiscal Year: 2009
    ....
  40. Alignments and Improved Refinements for High-Accuracy Protein Structure Modeling
    Patrice Koehl; Fiscal Year: 2009
    ..4) Organize all computer programs developed within this proposal into a user-centric package, including visual computing tools, to make it accessible to the biological community at large. ..
  41. Doppler Vascularity/Sonography--Breast Cancer Diagnosis
    Chandra Sehgal; Fiscal Year: 2005
    ..An integrated approach in which one mode represents tissue property and the other its function will result in a systematic and comprehensive diagnosis of breast cancers. ..
  42. IMPROVED QUANTITATIVE GA-65 SPECT IMAGING
    Stephen Moore; Fiscal Year: 2002
    ....
  43. RESEARCH TRAINING IN IMAGING METHODS FOR CANCER
    Stephen Moore; Fiscal Year: 2002
    ..Some didactic course work is offered at Harvard Medical School, Harvard School of Public Health, and Massachusetts Institute of Technology. The patient population includes those treated at Dana-Farber-Partners Cancer Care. ..
  44. INTEGRATING PHYSIOLOGY AND BEHAVIOR IN REAL TIME FMRI
    JAMES VOYVODIC; Fiscal Year: 2002
    ..Integrating the strategies addressed in this study will make fMRI a more sensitive and reliable brain imaging tool, thereby extending its capabilities for a wide range of both scientific and clinical applications. ..
  45. Radio-Immunotherapy (RIT) Planning Using SPECT
    LAWRENCE ZENG; Fiscal Year: 2004
    ..Novel image reconstruction algorithms will be developed to provided quantitative SPECT images. Our hypothesis will be verified through human observer studies and Channelized Hotelling observer studies. ..
  46. Contrast-Enhanced Ultrasound Detection of Angiogenesis
    Flemming Forsberg; Fiscal Year: 2004
    ..If successful, this project will permit non-invasive ultrasound evaluations of anti-angiogenic tumor therapies in animals as well as humans. ..
  47. Human Brain Protein MR Imaging and Spectroscopy at 3T
    Jinyuan Zhou; Fiscal Year: 2004
    ..The successful outcome of this application will offer a sensitive and specific modality in the clinical MRI examination of diseases. ..
  48. Image Reconstruction with Solid Srate SPECR
    LAWRENCE ZENG; Fiscal Year: 2005
    ..abstract_text> ..
  49. ADAPTIVE FUNCTIONAL MRI
    LAWRENCE PANYCH; Fiscal Year: 2002
    ....
  50. OPTIMIZING SOFTCOPY DISPLAYS FOR DIGITAL MAMMOGRAPHY
    Elizabeth Krupinski; Fiscal Year: 2002
    ..The JND metrix model will then be used to systematically explore and optimize CRT design tradeoffs for current and future digital-mammography display systems. ..
  51. fMRI Technique Development for Substance Abuse Research
    Blaise Frederick; Fiscal Year: 2005
    ..The long term goals of this research are to provide a better understanding of the phenomenon of cocaine abuse so that better prevention and treatment strategies can be developed and evaluated. ..
  52. Breast Cancer Imaging Using a Solid-State SPECT Camera
    G Zeng; Fiscal Year: 2005
    ..abstract_text> ..
  53. Quantifying Oxidative Metabolism in Diabetic Muscle
    BRUCE DAMON; Fiscal Year: 2005
    ..Moreover, these techniques will be suitable for future studies of the effects of exercise training or other interventions in diabetic animal models. ..
  54. Blood Flow in Small Animals by Ultrasound
    Chandra Sehgal; Fiscal Year: 2006
    ..abstract_text> ..
  55. Randomized Trial of EUS Neurolysis in Pancreas Cancer
    Michael Wallace; Fiscal Year: 2006
    ..The primary outcome will be a reduction in pain at 1 month. Secondary outcomes will include the durability of pain control, quality of life, narcotic use and narcotic side effects. [unreadable] [unreadable]..
  56. Conference--Medical Image Perception
    Elizabeth Krupinski; Fiscal Year: 2003
    ..This grant will be used to provide financial support for about 12 graduate students and residents, as well as logistic support for publicity and program printing. ..