drug stability

Summary

Top Publications

  1. ncbi Formulation and characterization of curcuminoids loaded solid lipid nanoparticles
    Waree Tiyaboonchai
    Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Naresuan University, Pitsanulok 65000, Thailand
    Int J Pharm 337:299-306. 2007
  2. ncbi Stability of protein pharmaceuticals: an update
    Mark Cornell Manning
    Legacy BioDesign LLC, Johnstown, Colorado 80534, USA
    Pharm Res 27:544-75. 2010
  3. ncbi Polymer-based nanocapsules for drug delivery
    C E Mora-Huertas
    Universite de Lyon, F 69622, Lyon, France
    Int J Pharm 385:113-42. 2010
  4. ncbi The in vitro stability and in vivo pharmacokinetics of curcumin prepared as an aqueous nanoparticulate formulation
    Chandana Mohanty
    Institute of Life Sciences, Nalco Square, Bhubaneswar, Orissa 751023, India
    Biomaterials 31:6597-611. 2010
  5. ncbi Protein drug stability: a formulation challenge
    Sven Frokjaer
    Department of Pharmaceutics, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK 2100 Copenhagen O, Denmark
    Nat Rev Drug Discov 4:298-306. 2005
  6. pmc Enhanced bioavailability of sirolimus via preparation of solid dispersion nanoparticles using a supercritical antisolvent process
    Min Soo Kim
    College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea
    Int J Nanomedicine 6:2997-3009. 2011
  7. ncbi The mechanisms of drug release from solid dispersions in water-soluble polymers
    Duncan Q M Craig
    The School of Pharmacy, The Queens University of Belfast, Medical Biology Centre, 97 Lisburn Road, BT9 7BL, Belfast, UK
    Int J Pharm 231:131-44. 2002
  8. ncbi Development of multiple W/O/W emulsions as dermal carrier system for oligonucleotides: effect of additives on emulsion stability
    T Schmidts
    Institute of Biopharmaceutical Technology, University of Applied Sciences Giessen Friedberg, 35390 Giessen, Germany
    Int J Pharm 398:107-13. 2010
  9. ncbi Lipid nanocarriers for dermal delivery of lutein: preparation, characterization, stability and performance
    Khalil Mitri
    Department of Pharmaceutics, Biopharmaceutics and NutriCosmetics, Freie Universitat Berlin, Institute of Pharmacy, Kelchstr 31, 12169 Berlin, Germany
    Int J Pharm 414:267-75. 2011
  10. ncbi Forced degradation of therapeutic proteins
    Andrea Hawe
    Division of Drug Delivery Technology, Leiden Amsterdam Center for Drug Research, 2300 RA Leiden, The Netherlands
    J Pharm Sci 101:895-913. 2012

Detail Information

Publications274 found, 100 shown here

  1. ncbi Formulation and characterization of curcuminoids loaded solid lipid nanoparticles
    Waree Tiyaboonchai
    Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Naresuan University, Pitsanulok 65000, Thailand
    Int J Pharm 337:299-306. 2007
    ..The results revealed that after storage in the absence of sunlight for 6 months, the percentages of the remaining curcumin, bisdemethoxycurcumin and demethoxycurcumin were 91, 96 and 88, respectively...
  2. ncbi Stability of protein pharmaceuticals: an update
    Mark Cornell Manning
    Legacy BioDesign LLC, Johnstown, Colorado 80534, USA
    Pharm Res 27:544-75. 2010
    ....
  3. ncbi Polymer-based nanocapsules for drug delivery
    C E Mora-Huertas
    Universite de Lyon, F 69622, Lyon, France
    Int J Pharm 385:113-42. 2010
    ..Consequently, the information obtained allows establishing criteria for selecting a method for preparation of nanocapsules according to its advantages, limitations and behaviours as a drug carrier...
  4. ncbi The in vitro stability and in vivo pharmacokinetics of curcumin prepared as an aqueous nanoparticulate formulation
    Chandana Mohanty
    Institute of Life Sciences, Nalco Square, Bhubaneswar, Orissa 751023, India
    Biomaterials 31:6597-611. 2010
    ..Thus, the results demonstrated nanoparticulate curcumin may be useful as a potential anticancer drug for treatment of various malignant tumors...
  5. ncbi Protein drug stability: a formulation challenge
    Sven Frokjaer
    Department of Pharmaceutics, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK 2100 Copenhagen O, Denmark
    Nat Rev Drug Discov 4:298-306. 2005
    ..This might in turn lead to generally accepted guidelines and tests to avoid unforeseen adverse effects in drug delivery...
  6. pmc Enhanced bioavailability of sirolimus via preparation of solid dispersion nanoparticles using a supercritical antisolvent process
    Min Soo Kim
    College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea
    Int J Nanomedicine 6:2997-3009. 2011
    ..The aim of this study was to improve the physicochemical properties and bioavailability of poorly water-soluble sirolimus via preparation of a solid dispersion of nanoparticles using a supercritical antisolvent (SAS) process...
  7. ncbi The mechanisms of drug release from solid dispersions in water-soluble polymers
    Duncan Q M Craig
    The School of Pharmacy, The Queens University of Belfast, Medical Biology Centre, 97 Lisburn Road, BT9 7BL, Belfast, UK
    Int J Pharm 231:131-44. 2002
    ..The implications of a deeper understanding of the dissolution mechanisms are discussed, with particular emphasis on optimising the choice of carrier and manufacturing method and the prediction of stability problems...
  8. ncbi Development of multiple W/O/W emulsions as dermal carrier system for oligonucleotides: effect of additives on emulsion stability
    T Schmidts
    Institute of Biopharmaceutical Technology, University of Applied Sciences Giessen Friedberg, 35390 Giessen, Germany
    Int J Pharm 398:107-13. 2010
    ..The most promising emulsions were chosen and further evaluated for their suitability and compatibility to incorporate a DNAzyme oligonucleotide as active pharmaceutical ingredient...
  9. ncbi Lipid nanocarriers for dermal delivery of lutein: preparation, characterization, stability and performance
    Khalil Mitri
    Department of Pharmaceutics, Biopharmaceutics and NutriCosmetics, Freie Universitat Berlin, Institute of Pharmacy, Kelchstr 31, 12169 Berlin, Germany
    Int J Pharm 414:267-75. 2011
    ..Based on size, stability and release/permeation data, and considering the chemical protection of the lutein prior to its absorption into the skin, the lipid nanoparticles are potential dermal nanocarriers for lutein...
  10. ncbi Forced degradation of therapeutic proteins
    Andrea Hawe
    Division of Drug Delivery Technology, Leiden Amsterdam Center for Drug Research, 2300 RA Leiden, The Netherlands
    J Pharm Sci 101:895-913. 2012
    ..Possible selection criteria to identify appropriate stress conditions and recommendations for setting up forced degradation studies for the different phases of development of therapeutic proteins are presented...
  11. ncbi Physical stability of proteins in aqueous solution: mechanism and driving forces in nonnative protein aggregation
    Eva Y Chi
    Department of Chemical Engineering, Center for Pharmaceutical Biotechnology, ECCH 111, Campus Box 424, University of Colorado, Boulder, Colorado, USA
    Pharm Res 20:1325-36. 2003
    ....
  12. ncbi Enhancement of oral bioavailability of atorvastatin calcium by self-emulsifying drug delivery systems (SEDDS)
    Pawan J Kadu
    R C Patel Institute of Pharmaceutical Education and Research, Shirpur, Dhule, Maharashtra, India
    Pharm Dev Technol 16:65-74. 2011
    ..The formulation significantly reduced serum lipid levels as compared with atorvastatin calcium. Thus studies illustrated the potential use for the delivery of hydrophobic drug such as atorvastatin calcium by oral route...
  13. ncbi Self-protecting core-shell magnetic nanoparticles for targeted, traceable, long half-life delivery of BCNU to gliomas
    Hung Wei Yang
    Molecular Medicine Research Center, Department of Chemical and Materials Engineering, Chang Gung University, 259 Wen Hwa 1st Road, Kuei Shan, Tao Yuan 33302, Taiwan, ROC
    Biomaterials 32:6523-32. 2011
    ..5 mg BCNU/kg carried by the nanocarrier versus 50 days for those that received 13.5 mg of free-BCNU). This improvement could enhance the potential of magnetic targeting therapy in clinical applications of cancer treatments...
  14. pmc Surgical wound healing using hemostatic gauze scaffold loaded with nanoparticles containing sustained-release granulocyte colony-stimulating factor
    Weien Yuan
    Department of Neurology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People s Republic of China
    Int J Nanomedicine 6:3139-49. 2011
    ....
  15. ncbi Design and ocular tolerance of flurbiprofen loaded ultrasound-engineered NLC
    E Gonzalez-Mira
    Department of Physical Chemistry, Faculty of Pharmacy, Institute of Nanoscience and Nanotechnology, University of Barcelona, Av Joan XXIII s n, 08028 Barcelona, Spain
    Colloids Surf B Biointerfaces 81:412-21. 2010
    ..The developed systems were shown physico-chemically stable with high tolerance for eye instillation...
  16. ncbi Production and characterization of Hesperetin nanosuspensions for dermal delivery
    Prabhat R Mishra
    Pharmaceutics Division, Central Drug Research Institute, Lucknow 226 001, India
    Int J Pharm 371:182-9. 2009
    ..Slight increases in size were found for the Poloxamer and the Tween stabilized nanosuspensions, which is not considered to impair their use in dermal formulations...
  17. ncbi Cremophor-free intravenous microemulsions for paclitaxel II. Stability, in vitro release and pharmacokinetics
    Adwoa O Nornoo
    Department of Pharmaceutical Sciences, Albany College of Pharmacy, Albany, NY 12208, USA
    Int J Pharm 349:117-23. 2008
    ....
  18. ncbi Cyclodextrins in drug delivery
    Thorsteinn Loftsson
    University of Iceland, Faculty of Pharmacy, Hagi, Reykjavik
    Expert Opin Drug Deliv 2:335-51. 2005
    ..Currently there are approximately 30 different pharmaceutical products worldwide containing drug/cyclodextrin complexes on the market...
  19. ncbi Preparation and evaluation of reverse-phase evaporation and multilamellar niosomes as ophthalmic carriers of acetazolamide
    Ahmed S Guinedi
    Department of Pharmaceutics, Faculty of Pharmacy, Ain Shams University, Monazamet El Wehda El Afrikia St, El Abbassia, Cairo, Egypt
    Int J Pharm 306:71-82. 2005
    ..Histological examination of corneal tissues after instillation of niosomal formulation for 40 days showed slight irritation in the substantia propria of the eye which is reversible and no major changes in tissues were observed...
  20. pmc Processing difficulties and instability of carbohydrate microneedle arrays
    Ryan F Donnelly
    Medical Biology Centre, School of Pharmacy, Queen s University Belfast, Belfast, UK
    Drug Dev Ind Pharm 35:1242-54. 2009
    ....
  21. ncbi Delivery of zoledronic acid encapsulated in folate-targeted liposome results in potent in vitro cytotoxic activity on tumor cells
    Hilary Shmeeda
    Experimental Oncology Laboratory, Shaare Zedek Medical Center, Jerusalem, Israel
    J Control Release 146:76-83. 2010
    ..The purpose of this study was to investigate whether liposomes targeted to the folate receptor (FR) can effectively deliver ZOL to tumor cells and enhance its in vitro cytotoxicity...
  22. ncbi Poly(ethylene oxide)-poly(propylene oxide) block copolymer micelles as drug delivery agents: improved hydrosolubility, stability and bioavailability of drugs
    Diego A Chiappetta
    Department of Pharmaceutical Technology, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
    Eur J Pharm Biopharm 66:303-17. 2007
    ....
  23. ncbi Nanostructured lipid matrices for improved microencapsulation of drugs
    R H Muller
    Department of Pharmaceutics, Biopharmaceutics and Biotechnology, Free University of Berlin, Kelchstr 31, 12169, Berlin, Germany
    Int J Pharm 242:121-8. 2002
    ..A special preparation process-applicable to NLC but also SLN-allows the production of highly concentrated particle dispersions (>30-95%). Potential applications as drug delivery system are described...
  24. ncbi Ethosomes - novel vesicular carriers for enhanced delivery: characterization and skin penetration properties
    E Touitou
    Department of Pharmaceutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, POB 12065, Jerusalem, Israel
    J Control Release 65:403-18. 2000
    ..Experiments using fluorescent probes and ultracentrifugation showed that the ethosomes had a high entrapment capacity for molecules of various lyophilicities...
  25. ncbi Secreted production of a custom-designed, highly hydrophilic gelatin in Pichia pastoris
    M W Werten
    Agrotechnological Research Institute ATO BV, Bornsesteeg 59, 6708 PD Wageningen, The Netherlands
    Protein Eng 14:447-54. 2001
    ..The spectrum was even more representative of the random coil conformation than the spectrum of natural non-hydroxylated gelatins...
  26. ncbi The effect of formulation excipients on protein stability and aerosol performance of spray-dried powders of a recombinant humanized anti-IgE monoclonal antibody
    J D Andya
    Pharmaceutical Research and Development, Genentech, Inc, South San Francisco, California 94080, USA
    Pharm Res 16:350-8. 1999
    ..To study the effect of trehalose, lactose, and mannitol on the biochemical stability and aerosol performance of spray-dried powders of an anti-IgE humanized monoclonal antibody...
  27. ncbi Anti-inflammatory activity of gel containing novel elastic niosomes entrapped with diclofenac diethylammonium
    A Manosroi
    Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand
    Int J Pharm 360:156-63. 2008
    ..This result has not only demonstrated the enhancement of transdermal absorption through rat skin, but also the in vivo anti-inflammatory effect of DCFD when entrapped in the developed novel elastic Tween 61 niosomes, as well...
  28. ncbi Enhanced oral bioavailability of puerarin using microemulsion vehicle
    Hongfei Wu
    Department of Pharmaceutics, Anhui University of Traditional Chinese Medicine, Anhui Province Key Laboratory of R and D of Chinese Medicine, Hefei, P R China
    Drug Dev Ind Pharm 35:138-44. 2009
    ..Puerarin microemulsion also showed good stability. These studies showed that microemulsion system of puerarin might be promising vehicles for the peroral delivery of puerarin...
  29. pmc Lipid-coated nano-calcium-phosphate (LNCP) for gene delivery
    Chenguang Zhou
    Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
    Int J Pharm 392:201-8. 2010
    ....
  30. ncbi Solid lipid nanoparticles for enhancing vinpocetine's oral bioavailability
    Yifan Luo
    School of Pharmacy, Department of Pharmaceutics, Mailbox 42, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016 Liaoning, P R China
    J Control Release 114:53-9. 2006
    ..These results indicated that VIN absorption is enhanced significantly by employing SLN formulations. SLNs offer a new approach to improve the oral bioavailability of poorly soluble drugs...
  31. ncbi Antibody structure, instability, and formulation
    Wei Wang
    Pfizer, Inc, Global Biologics, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017, USA
    J Pharm Sci 96:1-26. 2007
    ..Various aspects of formulation development have been examined to identify the critical attributes for the stabilization of antibodies...
  32. ncbi Preparation, characterization and biodistribution of the lactone form of 10-hydroxycamptothecin (HCPT)-loaded bovine serum albumin (BSA) nanoparticles
    Lei Yang
    School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang City, Liaoning, China
    Int J Pharm 340:163-72. 2007
    ..These results suggest that the HCPT-BSA nanoparticles seem to be a stable delivery system for poorly soluble HCPT or its derivatives...
  33. ncbi Polymer microneedles for controlled-release drug delivery
    Jung Hwan Park
    Wallace H Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    Pharm Res 23:1008-19. 2006
    ....
  34. ncbi Hydrophobically modified glycol chitosan nanoparticles-encapsulated camptothecin enhance the drug stability and tumor targeting in cancer therapy
    Kyung Hyun Min
    Biomedical Research Center, Korea Institute of Science and Technology, 39 1 Hawolgok Dong, Seongbuk gu, Seoul 136 791, Republic of Korea
    J Control Release 127:208-18. 2008
    ..These results reveal the promising potential of HGC nanoparticles-encapsulated CPT as a stable and effective drug delivery system in cancer therapy...
  35. ncbi The trehalose myth revisited: introduction to a symposium on stabilization of cells in the dry state
    J H Crowe
    Biostabilization Program, University of California, Davis, CA 95616, USA
    Cryobiology 43:89-105. 2001
    ..We review the available mechanisms for introducing trehalose into the cytoplasm of living cells as an introduction to the papers that follow...
  36. ncbi Enhanced solubility and stability of PEGylated liposomal paclitaxel: in vitro and in vivo evaluation
    Tao Yang
    College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
    Int J Pharm 338:317-26. 2007
    ..Therefore, our PEGylated liposomal formulation of paclitaxel could serve as a better alternative for the passive targeting of human breast tumors...
  37. ncbi Doxorubicin loaded pH-sensitive polymeric micelles for reversal of resistant MCF-7 tumor
    Eun Seong Lee
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, 421 Wakara Way, Suite 315, Salt Lake City, Utah 84108, USA
    J Control Release 103:405-18. 2005
    ..The results demonstrate that PHSM/f is a viable means for treating drug resistant tumors...
  38. ncbi Long-term physico-chemical stability of standard parenteral nutritions for neonates
    Lucie Bouchoud
    Pharmacy, Geneva University Hospitals, Gabrielle Perret Gentil 4, 1211 Geneva 14, Switzerland
    Clin Nutr 29:808-12. 2010
    ..Long-term physico-chemical stability for storage in wards was assessed...
  39. pmc Cyclotides, a novel ultrastable polypeptide scaffold for drug discovery
    Andrew Gould
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA
    Curr Pharm Des 17:4294-307. 2011
    ..The present review reports recent findings in the biological diversity and therapeutic potential of natural and engineered cyclotides...
  40. ncbi Preparation and the in vitro evaluation of nanoemulsion system for the transdermal delivery of granisetron hydrochloride
    Wen wu Zheng
    Department of Cardiology, People s Hospital of Luzhou, No 61 Zhongxiao Road, Luzhou, Sichuan Province, P R China
    Chem Pharm Bull (Tokyo) 58:1015-9. 2010
    ....
  41. ncbi A neural-network-based method for predicting protein stability changes upon single point mutations
    Emidio Capriotti
    Laboratory of Biocomputing, CIRB Department of Biology, University of Bologna, Bologna, Italy
    Bioinformatics 20:i63-8. 2004
    ..This allows the application of machine learning techniques to predicting free energy stability changes upon mutation starting from the protein sequence...
  42. ncbi Preparation and evaluation of alginate-chitosan microspheres for oral delivery of insulin
    Yueling Zhang
    National Key Lab of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, PR China
    Eur J Pharm Biopharm 77:11-9. 2011
    ..Therefore, the alginate-chitosan microspheres were found to be promising vectors showing a good efficiency in oral administration of protein or peptide drugs...
  43. pmc Stability-indicating HPLC-DAD/UV-ESI/MS impurity profiling of the anti-malarial drug lumefantrine
    Mathieu Verbeken
    Drug Quality and Registration group, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B 9000 Ghent, Belgium
    Malar J 10:51. 2011
    ..However, until now, no exhaustive impurity profile of lumefantrine has been established, encompassing process-related and degradation impurities in active pharmaceutical ingredients (APIs) and finished pharmaceutical products (FPPs)...
  44. ncbi Surface charged temoporfin-loaded flexible vesicles: in vitro skin penetration studies and stability
    Nina Dragicevic-Curic
    Department of Pharmaceutical Technology, Friedrich Schiller University Jena, Lessingstrasse 8, 07743 Jena, Germany
    Int J Pharm 384:100-8. 2010
    ..In conclusion, mTHPC-loaded cationic flexosomes could be a promising tool for delivering mTHPC to the skin, which would be beneficial for the photodynamic therapy of cutaneous malignant or non-malignant diseases...
  45. ncbi Enhancement of stability and skin permeation by sucrose stearate and cyclodextrins in progesterone nanoemulsions
    Victoria Klang
    University of Vienna, Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Life Sciences, Althanstrasse 14, 1090 Vienna, Austria
    Int J Pharm 393:152-60. 2010
    ....
  46. ncbi Resveratrol-loaded calcium-pectinate beads: effects of formulation parameters on drug release and bead characteristics
    Surajit Das
    Faculty of Science, Department of Pharmacy, National University of Singapore, Singapore
    J Pharm Sci 99:840-60. 2010
    ..5%) and can be used for delayed release and site-specific delivery to the lower GI tract. Depending on the formulation parameters, release of resveratrol after 10 h incubation in the intestinal media was 80-100%...
  47. ncbi Quantitative determination of imatinib in human plasma with high-performance liquid chromatography and ultraviolet detection
    Masatomo Miura
    Department of Pharmacy, Akita University Hospital, 1 1 1 Hondo, Akita 010 8543, Japan
    J Chromatogr Sci 49:412-5. 2011
    ..This method can be applied effectively to measure imatinib concentrations in clinical samples...
  48. pmc Polyanionic carbohydrate doxorubicin-dextran nanocomplex as a delivery system for anticancer drugs: in vitro analysis and evaluations
    Parisa Yousefpour
    Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    Int J Nanomedicine 6:1487-96. 2011
    ..DOX-DS nanocomplexes may serve as a drug delivery system with efficient drug encapsulation and also may be taken into consideration in designing DOX controlled-release systems...
  49. ncbi Surfactant dependent toxicity of lipid nanocapsules in HaCaT cells
    Caroline Maupas
    Laboratory of Pharmaceutical Engineering, University Franche Comté, Besancon, France
    Int J Pharm 411:136-41. 2011
    ..LNC appear to be appropriate as carrier for cutaneous delivery however toxicity can vary distinctly depending on the surfactant used for the preparation...
  50. ncbi Application of different methods to formulate PEG-liposomes of oxaliplatin: evaluation in vitro and in vivo
    Sara Zalba
    Department of Pharmacy and Pharmaceutical Technology, University of Navarra, Pamplona, Spain
    Eur J Pharm Biopharm 81:273-80. 2012
    ..In conclusion, the FM was the simplest method in comparison with REV and HM to develop in vivo stable and efficient PEG-coated liposomes of oxaliplatin with a loading higher than those reported for REV...
  51. ncbi Development and evaluation of self-microemulsifying liquid and pellet formulations of curcumin, and absorption studies in rats
    Saipin Setthacheewakul
    Department of Pharmaceutical Technology, Prince of Songkla University, Songkhla, Thailand
    Eur J Pharm Biopharm 76:475-85. 2010
    ..These studies demonstrate that the new self-microemulsifying systems in liquid and pellet forms are promising strategies for the formulation of poorly soluble lipophilic compounds with low oral bioavailability...
  52. ncbi Stabilization and encapsulation of recombinant human erythropoietin into PLGA microspheres using human serum albumin as a stabilizer
    Jintian He
    Hebei Normal University, Hebei Province, People s Republic of China he
    Int J Pharm 416:69-76. 2011
    ..The results suggested that the integrity of rhEPO was successfully protected during the encapsulation process and the release period from polymeric matrices...
  53. pmc A novel tropically stable oral amphotericin B formulation (iCo-010) exhibits efficacy against visceral Leishmaniasis in a murine model
    Ellen K Wasan
    School of Health Sciences, British Columbia Institute of Technology, Burnaby, Canada
    PLoS Negl Trop Dis 4:e913. 2010
    ..To develop an oral formulation of amphotericin B (AmB) that is stable at the temperatures of WHO Climatic Zones 3 and 4 (30-43 °C) and to evaluate its efficacy in a murine model of visceral leishmaniasis (VL)...
  54. ncbi Preparation and characterization of solid lipid nanoparticles loaded with doxorubicin
    Robhash Kusam Subedi
    BK21 Project Team, College of Pharmacy, Chosun University, 375 Seosuk dong, Dong Gu, Gwangju 501 759, South Korea
    Eur J Pharm Sci 37:508-13. 2009
    ..05) after 1 year of storage at 4 degrees C. In conclusion, SLN with small particle size, high EE, and relatively high DL for doxorubicin can be obtained by this method...
  55. ncbi Development and characterization of oral lipid-based amphotericin B formulations with enhanced drug solubility, stability and antifungal activity in rats infected with Aspergillus fumigatus or Candida albicans
    Ellen K Wasan
    School of Health Sciences, British Columbia Institute of Technology, 3700 Willingdon Avenue, Burnaby, BC, Canada
    Int J Pharm 372:76-84. 2009
    ....
  56. ncbi Review: physical chemistry of solid dispersions
    Sandrien Janssens
    Laboratorium voor Farmacotechnologie en Biofarmacie, Katholieke Universiteit Leuven, Leuven, Belgium
    J Pharm Pharmacol 61:1571-86. 2009
    ..Nevertheless, some issues have to be considered regarding thermodynamic instability, as well in supersaturated solutions that are formed upon dissolution as in the solid state...
  57. pmc Towards heat-stable oxytocin formulations: analysis of degradation kinetics and identification of degradation products
    Andrea Hawe
    Division of Drug Delivery Technology, Leiden Amsterdam Center for Drug Research LACDR, Leiden University, P O Box 9502, 2300 RA Leiden, The Netherlands
    Pharm Res 26:1679-88. 2009
    ..To investigate degradation kinetics of oxytocin as a function of temperature and pH, and identify the degradation products...
  58. ncbi Drug delivery systems: entering the mainstream
    Theresa M Allen
    Department of Pharmacology, University of Alberta, Edmonton T6G 2H7, Canada
    Science 303:1818-22. 2004
    ..Furthermore, there is considerable interest in exploiting the advantages of DDS for in vivo delivery of new drugs derived from proteomics or genomics research and for their use in ligand-targeted therapeutics...
  59. ncbi Oral immunization against hepatitis B using bile salt stabilized vesicles (bilosomes)
    Anshuman Shukla
    Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, India
    J Pharm Pharm Sci 11:59-66. 2008
    ..Another purpose of this study was to determine the dose that could produce serum antibody titres against hepatitis B via the oral route compared to those following intramuscular immunization...
  60. ncbi Lung-targeting microspheres of carboplatin
    B Lu
    West China School of Pharmacy, Sichuan University, 17, 3rd Block, Renmin South Road, Chengdu 610041, China
    Int J Pharm 265:1-11. 2003
    ....
  61. ncbi Lipid nanocapsules: ready-to-use nanovectors for the aerosol delivery of paclitaxel
    Jose Hureaux
    Pulmonology Department, Academic Hospital, Angers, France
    Eur J Pharm Biopharm 73:239-46. 2009
    ..Chemical parameters, such as acidity and osmolarity, were optimised, and a storage procedure for PTX-LNC batches was set-up. Animal studies are now needed to determine the tolerance and therapeutic potential of LNC dispersion aerosols...
  62. ncbi Ofloxacin targeting to lungs by way of microspheres
    Sree Harsha
    Department of Pharmaceutics, College of Clinical Pharmacy, King Faisal University, Al Ahsa, Hufof, Saudi Arabia
    Int J Pharm 380:127-32. 2009
    ..32 microg g(-1) ALOME found to release the drug to a maximum extent in the target tissue, lung. Histopathological studies proved the tissue compatibility of ALOME to be safe...
  63. ncbi Nano-sized water-in-oil-in-water emulsion enhances intestinal absorption of calcein, a high solubility and low permeability compound
    Kenjiro Koga
    Department of Clinical Pharmaceutics, Hokuriku University, Kanazawa, Japan
    Eur J Pharm Biopharm 74:223-32. 2010
    ..These results suggested that HS-11 or Gelucire 44/14+PVA are safe outer water phase additives and that 0.1-microm pore-sized SPGs are important for preparing w/o/w emulsions that enhanced intestinal calcein absorption...
  64. ncbi Tamoxifen in topical liposomes: development, characterization and in-vitro evaluation
    Amit Bhatia
    Sun Pharma Advanced Research Centre, Vadodara, Gujrat, India
    J Pharm Pharm Sci 7:252-9. 2004
    ..With this objective, tamoxifen loaded liposomal systems have been prepared and their topical performance has been compared with non-liposomal systems containing tamoxifen...
  65. ncbi Amoxicillin-loaded polyethylcyanoacrylate nanoparticles: influence of PEG coating on the particle size, drug release rate and phagocytic uptake
    G Fontana
    Dipartimento di Chimica e Tecnologie Farmaceutiche, Universita di Palermo, Italy
    Biomaterials 22:2857-65. 2001
    ..pylori by peroral administration...
  66. ncbi Preparation of camptothecin-loaded polymeric micelles and evaluation of their incorporation and circulation stability
    Masato Watanabe
    Institute of Medicinal Chemistry, Hoshi University, Ebara 2 4 41, Shinagawa ku, Tokyo 142 8501, Japan
    Int J Pharm 308:183-9. 2006
    ..This CPT-loaded micelles showed about a 17-fold lower blood clearance value than unstable micelles. The CPT-loaded micelles are potentially delivered to tumor sites owing to an extended circulation in the blood stream...
  67. ncbi Formation of nano/micro-dispersions with improved dissolution properties upon dispersion of ritonavir melt extrudate in aqueous media
    Ingunn Tho
    Drug Transport and Delivery Group, Dept of Pharmacy, University of Tromsoe, N 9037 Tromsoe, Norway
    Eur J Pharm Sci 40:25-32. 2010
    ....
  68. ncbi PEGylated nanostructured lipid carriers loaded with 10-hydroxycamptothecin: an efficient carrier with enhanced anti-tumour effects against lung cancer
    Xinxin Zhang
    School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, P O Box 122, Shenyang 110016, PR China
    J Pharm Pharmacol 60:1077-87. 2008
    ..These results suggest that PEG-NLCs is a promising delivery system for HCPT in the treatment of lung cancer...
  69. ncbi An overview of liposome lyophilization and its future potential
    Chengjun Chen
    College of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, No 103, Shenyang, 110016, PR China
    J Control Release 142:299-311. 2010
    ..Finally, the major areas and future potential of research on lyophilized liposomes are highlighted...
  70. ncbi Risk factors for improper vaccine storage and handling in private provider offices
    K N Bell
    Women s and Children s Center, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
    Pediatrics 107:E100. 2001
    ....
  71. ncbi Formulation and in vitro evaluation of a cosmetic emulsion from almond oil
    Naveed Akhtar
    Faculty of Pharmacy and Alternative Medicine, Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
    Pak J Pharm Sci 21:430-7. 2008
    ....
  72. ncbi Novel crystalline solid dispersion of tranilast with high photostability and improved oral bioavailability
    Yohei Kawabata
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Eur J Pharm Sci 39:256-62. 2010
    ..According to these observations, taken together with dissolution and pharmacokinetic behaviors, crystalline solid dispersion strategy would be efficacious to enhance bioavailability of TL with high photochemical stability...
  73. ncbi The effect of PEG coating on in vitro cytotoxicity and in vivo disposition of topotecan loaded liposomes in rats
    S Dadashzadeh
    Department of Pharmaceutics, School of Pharmacy, Shaheed Beheshti Medical University, Tehran, Iran
    Int J Pharm 353:251-9. 2008
    ..PEGylated liposome resulted in a 52-fold and 2-fold increases in AUC(0-infinity) compared with that of free topotecan and CL, respectively. These results indicated that PEG modified liposome might be an effective carrier for topotecan...
  74. ncbi Preparation of polysaccharide glassy microparticles with stabilization of proteins
    Weien Yuan
    Shanghai Jiaotong University, School of Pharmacy, Shanghai, 200240, China
    Int J Pharm 366:154-9. 2009
    ....
  75. ncbi NGR-modified micelles enhance their interaction with CD13-overexpressing tumor and endothelial cells
    Xun Wang
    State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, People s Republic of China
    J Control Release 139:56-62. 2009
    ..Therefore, it was concluded that NGR-PM could be a potential vehicle for delivering hydrophobic chemotherapeutic agents to CD13-overexpressing tumors...
  76. ncbi Stabilization and encapsulation of photosensitive resveratrol within yeast cell
    Guorong Shi
    College of Biological and Technology, Hunan Agricultural University, Changsha 410128, PR China
    Int J Pharm 349:83-93. 2008
    ..In addition, the yeast-encapsulated resveratrol exhibited good stability, and its bioavailability was enhanced as a result of increased solubility of resveratrol and sustained releasing...
  77. ncbi Formulation of sirolimus eye drops and corneal permeation studies
    Guido Buech
    Institute of Pharmacy, Free University of Berlin, Berlin, Germany
    J Ocul Pharmacol Ther 23:292-303. 2007
    ..They are not suitable to achieve therapeutic concentrations in the aqueous humour of patients with intact cornea...
  78. ncbi In-vitro release kinetics and stability of anticardiovascular drugs-intercalated layered double hydroxide nanohybrids
    H S Panda
    Department of Metallurgical Engineering and Materials Science, Indian Institute of Technology, Bombay, Mumbai 400076, India
    J Phys Chem B 113:15090-100. 2009
    ....
  79. ncbi Q10-loaded NLC versus nanoemulsions: stability, rheology and in vitro skin permeation
    Varaporn B Junyaprasert
    Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Thailand
    Int J Pharm 377:207-14. 2009
    ..From in vitro permeation studies, it could be stated that the amount of Q(10) released and occlusiveness were major keys to promote the deep penetration of Q(10) into the skin...
  80. ncbi Recent advances in the stabilization of proteins encapsulated in injectable PLGA delivery systems
    Steven P Schwendeman
    Department of Pharmaceutical Sciences, The University of Michigan, Ann Arbor 48109 1065, USA
    Crit Rev Ther Drug Carrier Syst 19:73-98. 2002
    ..Described here are recent advances in the stabilization of proteins encapsulated in PLGA delivery systems...
  81. ncbi BCNU-loaded PEG-PLLA ultrafine fibers and their in vitro antitumor activity against Glioma C6 cells
    Xiuling Xu
    State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
    J Control Release 114:307-16. 2006
    ..These results strongly suggest that the BCNU/PEG-PLLA fibers have an effect of controlled release of BCNU and are suitable for postoperative chemotherapy of cancers...
  82. ncbi Encapsulation of proteins in biodegradable polymeric microparticles using electrospray in the Taylor cone-jet mode
    Jingwei Xie
    Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117576
    Biotechnol Bioeng 97:1278-90. 2007
    ..Findings of the present study demonstrate that this novel electrospray method is a promising approach to encapsulate bioactive materials such as proteins, enzymes, antibiotics, and DNA fragments in biodegradable polymeric particles...
  83. pmc Freeze drying of peptide drugs self-associated with long-circulating, biocompatible and biodegradable sterically stabilized phospholipid nanomicelles
    Sok Bee Lim
    Department of Biopharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL 60612 7231, USA
    Int J Pharm 356:345-50. 2008
    ..In conclusion, we found that peptide drug-SSM interactions are conserved during lyophilization...
  84. ncbi Feasibility of microneedles for percutaneous absorption of insulin
    Yukako Ito
    Department of Pharmacokinetics, Kyoto Pharmaceutical University, Kyoto, Japan
    Eur J Pharm Sci 29:82-8. 2006
    ..The wound formed by the administration of microneedle was cured at 72 h after administration. Those results suggest the usefulness of a self-dissolving microneedle for the percutaneous delivery of peptide/protein drugs like insulin...
  85. ncbi Beta-carotene-loaded nanostructured lipid carriers
    A Hentschel
    Dept of Food Process Engineering, Technische Univ Berlin, Faculty of Process Sciences, Amrumer Str 32, 13353 Berlin, Germany
    J Food Sci 73:N1-6. 2008
    ..Furthermore, stability of the beta-carotene in water dependent on NLC concentration and tocopherol content was measured photospectrometrically to get an estimation of the behavior of NLC in beverages...
  86. ncbi Camptothecin in sterically stabilized phospholipid micelles: a novel nanomedicine
    Otilia M Koo
    Department of Biopharmaceutical Sciences, University of Illinois, Chicago, Illinois, USA
    Nanomedicine 1:77-84. 2005
    ..It was the aim of this study to develop and evaluate in vitro camptothecin-containing SSM (CPT-SSM) as a novel nanomedicine for parenteral administration...
  87. ncbi Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication
    David V Morrissey
    Sirna Therapeutics, Inc, Boulder, CO 80301, USA
    Hepatology 41:1349-56. 2005
    ..In conclusion, these experiments establish the strong impact that siRNAs can have on the extent of HBV infection and underscore the importance of stabilization of siRNA against nuclease degradation...
  88. ncbi Cyclodextrins as pharmaceutical solubilizers
    Marcus E Brewster
    Chemical and Pharmaceutical Development, Johnson and Johnson Pharmaceutical Research and Development, Janssen Pharmaceutica, Turnhoutseweg 30, B 2340 Beerse, Belgium
    Adv Drug Deliv Rev 59:645-66. 2007
    ..This review is intended to give a general background to the use of cyclodextrin as solubilizers as well as highlight kinetic and thermodynamic tools and parameters useful in the study of drug solubilization by cyclodextrins...
  89. ncbi Preparation and characterization of stearic acid nanostructured lipid carriers by solvent diffusion method in an aqueous system
    Fu Qiang Hu
    School of Pharmaceutical Science, Zhejiang University, 353, Yanan Road, Hangzhou 310031, PR China
    Colloids Surf B Biointerfaces 45:167-73. 2005
    ....
  90. ncbi Strategic approaches for overcoming peptide and protein instability within biodegradable nano- and microparticles
    Ugo Bilati
    School of Pharmacy, University of Geneva, Geneva, Switzerland
    Eur J Pharm Biopharm 59:375-88. 2005
    ..Artefacts that might occur during sampling and analytical procedures and which might hinder critical interpretation of results are discussed...
  91. ncbi Quantification of imatinib in human plasma by high-performance liquid chromatography-tandem mass spectrometry
    Karine Titier
    Department of Clinical Pharmacology and Toxicology, Pellegrin Hospital and University Victor Segalen, 33076 Bordeaux, France
    Ther Drug Monit 27:634-40. 2005
    ..It can be used to evaluate patient adherence to daily oral therapy, drug-drug interactions, or pharmacokinetic/pharmacodynamic relationships...
  92. pmc Modification of composition of a nanoemulsion with different cholesteryl ester molecular species: effects on stability, peroxidation, and cell uptake
    Cristina P Almeida
    Lipid Metabolism Laboratory, Heart Institute InCor, Medical School Hospital, University of Sao Paulo, Sao Paulo, Brazil
    Int J Nanomedicine 5:679-86. 2010
    ..Here, it was tested whether modifications of core particle constitution could affect the characteristics and biologic properties of lipid nanoemulsions...
  93. ncbi Self-nanoemulsifying drug delivery systems of tamoxifen citrate: design and optimization
    Yosra S R Elnaggar
    Department of Pharmaceutics, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt yosra
    Int J Pharm 380:133-41. 2009
    ..Realizing drug incorporation into an optimized nano-sized SNEDD system that encompasses a bioactive surfactant, our results proposed that the prepared system could be promising to improve oral efficacy of the tamoxifen citrate...
  94. pmc Liposomes containing glycocholate as potential oral insulin delivery systems: preparation, in vitro characterization, and improved protection against enzymatic degradation
    Mengmeng Niu
    School of Pharmacy, Fudan University, Shanghai, People s Republic of China
    Int J Nanomedicine 6:1155-66. 2011
    ..The present study aimed to develop a liposomal delivery system containing glycocholate as an enzyme inhibitor and permeation enhancer for oral insulin delivery...
  95. ncbi Cholesterol as a bilayer anchor for PEGylation and targeting ligand in folate-receptor-targeted liposomes
    Xiaobin B Zhao
    Division of Pharmaceutics, NCI OSU Comprehensive Cancer Center, NSF Nanoscales Science and Engineering Center NSEC, College of Pharmacy, The Ohio State University, 542 LM Parks Hall, 500 W 12th Ave, Columbus, Ohio 43210, USA
    J Pharm Sci 96:2424-35. 2007
    ..In addition, in vivo circulation of cholesterol-anchored liposomes was prolonged compared to non-PEGylated liposomes. These studies suggest that cholesterol is a viable bilayer anchor for synthesis of PEGylated and FR-targeted liposomes...
  96. pmc A novel Doxorubicin prodrug with controllable photolysis activation for cancer chemotherapy
    Stuart Ibsen
    Department of Bioengineering, Moores Cancer Center, University of California San Diego, 3855 Health Sciences Dr 0815, La Jolla, California 92093 0815, USA
    Pharm Res 27:1848-60. 2010
    ..The purpose of this study was to develop a controllably activatable chemotherapy prodrug of DOX created by blocking its free amine group with a biotinylated photocleavable blocking group (PCB)...
  97. ncbi Nanoscale thermal analysis of pharmaceutical solid dispersions
    Jianxin Zhang
    Molecular Profiles Ltd, 8 Orchard Place, Nottingham Business Park, Nottingham, UK
    Int J Pharm 380:170-3. 2009
    ..and detecting the state of the drug inside such a polymer matrix is critically important since issues such as drug stability, safety and efficacy can be greatly affected...
  98. pmc Preparation and in vitro characterization of 9-nitrocamptothecin-loaded long circulating nanoparticles for delivery in cancer patients
    Katayoun Derakhshandeh
    Department of Pharmaceutics, Faculty of Pharmacy, University of Medical Science, Kermanshah 67145 1673, Iran
    Int J Nanomedicine 5:463-71. 2010
    ..These experimental results indicate that PLGA-PEG-NPs (versus PLGA-NPs) have a better physicochemical characterization and can be developed as a drug carrier in order to treat different malignancies...
  99. ncbi Protect from light: photodegradation and protein biologics
    Bruce A Kerwin
    Department of Protein Pharmaceutics, Amgen, Inc, One Amgen Center Drive, Thousand Oaks, California 91320, USA
    J Pharm Sci 96:1468-79. 2007
    ..It is our intent to spur additional research in this area for increasing the safety and effectiveness of biopharmaceutical products...
  100. ncbi Effect of resveratrol incorporated in liposomes on proliferation and UV-B protection of cells
    C Caddeo
    University of Ljubljana, Faculty of Pharmacy, Ljubljana, Slovenia
    Int J Pharm 363:183-91. 2008
    ....
  101. ncbi Pluronic block copolymers in drug delivery: from micellar nanocontainers to biological response modifiers
    Alexander V Kabanov
    College of Pharmacy, Department of Pharmaceutical Sciences, Nebraska Medical Center, Omaha 68198 6025, USA
    Crit Rev Ther Drug Carrier Syst 19:1-72. 2002
    ..Finally, Pluronic formulations were shown to enhance transgene expression in the body. This opens new possibilities for the use of Pluronic in gene therapies...

Research Grants41

  1. N-methanocarbathymidine (N-MCT) for the Treatment of Herpes and Pox Virus Infecti
    Aquilur Rahman; Fiscal Year: 2013
    ..11) High drug stability at room temperature over one year with no decomposition SPECIFIC AIMS N&N proposes to develop the first of ..
  2. SQUAMOUS CELL CARCINOMAS - EFFECTS OF RETINOIDS
    Lorraine J Gudas; Fiscal Year: 2013
    ..We will test zebularine, a potent inhibitor of DNMTases, which exhibits excellent drug stability and has shown positive results in other cancer prevention models...
  3. Pre-clinical Development of a Broad Spectrum Antiviral Compound to Treat Human Pa
    Christopher Fisher; Fiscal Year: 2012
    ..includes 1) initial chemical scale up, non-GLP toxicology and pharmacokinetic studies;2) Pre-formulation and drug stability studies, and development of 25 initial topical formulations using ingredients approved or ingredients ..
  4. Development of an HIV-1 entry inhibitor pre-drug as a microbicide
    Min Lu; Fiscal Year: 2012
    ..b) Evaluate their toxicity, immunogenicity and drug stability in the rabbit model...
  5. Self-microencapsulation in polymer delivery systems without organic solvents
    Steven P Schwendeman; Fiscal Year: 2010
    ..can be prepared reproducibly by self-microencapsulation, and the resulting polymer will exhibit excellent drug stability and release performance both in vitro and in vivo...
  6. PEPTIDE DEGRADATION IN POLYMER MATRICES
    Elizabeth Topp; Fiscal Year: 2001
    ..revolution, are now entering the marketplace and presenting pharmaceutical science with challenges in drug stability and delivery that range from basic science to developmental technology...
  7. Rapid, Bedside, Liquification of Solid Drugs
    BRUCE MORTIMER; Fiscal Year: 2002
    ..device optimized to liquify solid medications, and examine the processing variables to maximize efficiency and drug stability. The Phase II study would complete the processing variable study, consider methods of direct administration, ..
  8. PEPTIDE DEGRADATION IN POLYMER MATRICES
    Elizabeth Topp; Fiscal Year: 2003
    ..revolution, are now entering the marketplace and presenting pharmaceutical science with challenges in drug stability and delivery that range from basic science to developmental technology...
  9. TUMOR-TARGETED RADIOSENSITIZERS IN CANCER THERAPY
    MARTIN SCHNEIDERMAN; Fiscal Year: 2001
    ..When compared to free metronidazole, conjugates yield improved tumor-plasma ratios, increased drug stability, and reduced toxicity in mice...
  10. LTQ-FT MS System for On-line Protein and Glycan Analysis
    Catherine Costello; Fiscal Year: 2009
    ..wound healing in the eye (Trinkaus-Randall) and protein remodeling that accompanies aging and that affects drug stability (O'Connor)...
  11. DEVELOPMENT OF DRUG INHIBITORS OF SRC
    Victor Levin; Fiscal Year: 2000
    ..The Fourth Program will determine basic drug stability, potential for gastrointestinal absorption, and basic animal bioavailability and biodistribution for selected ..
  12. PHARMACEUTICAL SUPPORT FOR PRECLINICAL DRUG DEVELOPMENT
    CHARLES SPARACINO; Fiscal Year: 1999
    ..development may involve chemical analyses, analytical methods development, efficacy and toxicity evaluations, drug stability studies, and development of the pharmaceutical dosage form...
  13. FORMULATION DEVELOPMENT OF PHARMACEUTICAL DOSAGE FORMS
    VALENTINO STELLA; Fiscal Year: 1999
    ..of drugs identified for formulation development, and identify potential drug-excipient interactions. Determine drug stability alone and in dosage formulation, and define drug release properties.
  14. New Ligands for Radioimmunotherapy and MRI of Cancer
    Hyun Soon Chong; Fiscal Year: 2006
    ..The results of the proposed research will contribute to the development of better drugs for both MRI and RIT, which will greatly enhance clinical exploration of both modalities, and directly benefit cancer patients. ..
  15. Localized modulation of RPE P-gp/MRP activity for back-of-the-eye drug delivery
    Soumyajit Majumdar; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  16. Medication Adherence in Adolescents with Hypertension
    Renee Robinson; Fiscal Year: 2005
    ..effective assessment methods to identify risk factors for non-adherence and to improve long-term medication adherence in children and adolescents suffering from chronic renal diseases, such as hypertension or solid organ transplantation ..
  17. Dock and Lock: novel protein engineering
    Chien Hsing Chang; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  18. Ab Alphavirus Replicon Vaccine against Cytomegalovirus
    Robert Esch; Fiscal Year: 2005
    ..PROPOSED COMMERCIAL APPLICATIONS: An effective CMV vaccine will prevent mental retardation and hearing loss associated with congenital CMV disease, thereby addressing an important unmet public health problem. ..
  19. Bioengineering of the blood-brain barrier permeability
    Serguei Vinogradov; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  20. Passivating Proteins in Implantable Glucose Sensors
    W Ward; Fiscal Year: 2004
    ..8. A histologic evaluation will be performed to assess the effect of passivating proteins and antibody blocked fibrinogen on the nature of the foreign body capsule. ..
  21. Assesment of a Chronic Subcutaneous Glucose Sensor
    W Ward; Fiscal Year: 2003
    ..ether-based polymer. We will compare their long term function in studies using rabbits, which will be also be used to ascertain the effect of the growth factors and the real-time data processing. ..
  22. Novel RNase-based Immunotoxin for CD74-positive B-cell Malignancies
    Chien Hsing Chang; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  23. Polymer-Nucleotide Complexes with Cytotoxic Activity
    Serguei Vinogradov; Fiscal Year: 2007
    ..Application of the drug forms may help to prevent many of the known chemotherapy side effects. Data accumulated in these studies can be directly used for design of better systemic formulations of cytotoxic nucleotide drugs. ..
  24. Bicarbonate Enhances Peroxidation of SOD/ALS Mutants
    Balaraman Kalyanaraman; Fiscal Year: 2008
    ....
  25. Chemical Mechanism of Guanine Deamination
    Rainer Glaser; Fiscal Year: 2003
    ..5. The computational studies will include studies of the bimolecular reaction mechanisms for dediazoniation of the nucleobase diazonium ions. ..
  26. Platelet Liposomal Drug Delivery--Thrombosis /Restenosis
    Shuwu Wang; Fiscal Year: 2006
    ..The targeted liposomal system proposed could reduce the costs in both treatment areas with a 5% reduction in revascularizations alone leading to >$60 million annual medical cost savings. ..
  27. Peroxide, NO and Iron Signaling in Endothelial Damage
    Balaraman Kalyanaraman; Fiscal Year: 2007
    ..Novelty: This proposal presents a new insight on peroxide-induced iron signaling in endothelial apoptosis and on the role of NO and antioxidants in mitigating these effects. ..
  28. BIOCHEMICAL STUDIES OF 14 KDA PHOSPHOLIPASES A2
    Michael Gelb; Fiscal Year: 2006
    ..These studies will contribute to our fundamental understanding of how mammalian cells initiate the eicosanoid cascade. ..
  29. Joint Action Analysis of Poly-drug Withdrawal
    Robert Raffa; Fiscal Year: 2006
    ..g., electrophysiologic or molecular biology techniques. An improved understanding of how withdrawal is influenced by poly-drug abuse could lead to development of enhanced clinical treatment. ..
  30. VITAMIN K INSUFFICIENCY--A RISK FACTOR FOR OSTEOPOROSIS
    Sarah Booth; Fiscal Year: 2001
    ..Results of the studies proposed could lead to effective intervention programs that reduce bone loss resulting in a decreased risk and incidence of osteoporosis. ..
  31. Vitamin K: vascular calcification and age-related bone *
    Sarah Booth; Fiscal Year: 2004
    ..The proposed ancillary trial provides a unique opportunity to determine if vitamin K supplementation will reduce progression of vascular calcification in older men and women...
  32. Dietary & non-dietary components of vitamin K metabolism
    Sarah Booth; Fiscal Year: 2008
    ..The findings of the proposed study are critical for the interpretation of the epidemiologic and clinical data used to determine optimal intakes at which vitamin K may have a protective role in bone health. ..
  33. Effect of Vitamin K on Age-Related Bone Loss
    Sarah Booth; Fiscal Year: 2005
    ..The proposed trial provides a unique opportunity to determine if supplemental vitamin K will reduce age-related bone loss in elderly men and women, above that achieved by supplemental calcium and vitamin D alone. ..
  34. Struc Determin of Supramolec Machines by Hybrid Methods
    PAMELA BJORKMAN; Fiscal Year: 2004
    ..The Workshop is being extensively advertised and will be as inclusive and diversity-sensitive as the organizers can achieve and the 120-participant will allow. ..
  35. Targeted Liposomal Doxorubicin Delivery to Leukemia
    Robert Lee; Fiscal Year: 2007
    ..abstract_text> ..
  36. HFE/Transferrin Receptor/Transferrin Interactions
    PAMELA BJORKMAN; Fiscal Year: 2006
    ..4) and binds to HFE with the opposite pH dependence. Results from these studies will be critical for understanding how interactions between TfR, HFE, and Fe-Tf are involved in regulating iron homeostasis. ..
  37. PERMEATION OF IRRITANT MIXTURES THRU PROTECTIVE MATERIAL
    SHANE QUE HEE; Fiscal Year: 2002
    ..The relationship of the fundamental independent variables to the kinetic parameters of permeation and to the Corrositex rating as the index of irritation will be determined and compared. ..
  38. Inductively Coupled Plasma- Mass Spectrometer
    SHANE QUE HEE; Fiscal Year: 2003
    ..A team of researchers has been assembled whose research needs for elemental analyses are in the broad areas of environmental health, nutrition, biomedical and behavioral research. ..
  39. NEONATAL FC RECEPTOR/IGG INTERACTION
    PAMELA BJORKMAN; Fiscal Year: 2001
    ..5 to address the possibility of pH-dependent conformational changes. To answer the third question, mutants of FcRn with an open, MHC-like peptide-binding groove will be constructed and characterized. ..
  40. ACOUSTICALLY ACTIVATED MICELLAR DRUG DELIVERY
    Natalya Rapoport; Fiscal Year: 2001
    ....
  41. HTS assays for discovery of novel beta-lactamase inhibitors via click chemistry
    Peter Hodder; Fiscal Year: 2008
    ..In consort with Prof. Barry Sharpless (TSRI: Dept of Chemistry), we will screen "click-chemistry" libraries for a synergistic and novel approach to the rapid synthesis and discovery of beta-lactamase inhibitors. [unreadable]..