- Fluid flow increases mineralized matrix deposition in 3D perfusion culture of marrow stromal osteoblasts in a dose-dependent manner
Gregory N Bancroft
Department of Bioengineering, Rice University, 6100 Main, Houston, TX 77005, USA
Proc Natl Acad Sci U S A 99:12600-5. 2002
..To investigate this phenomenon in vitro, marrow stromal osteoblasts were cultured on 3D scaffolds under flow perfusion with different rates of flow for an extended period to permit osteoblast differentiation and significant matrix ..
- Microfluidic local perfusion chambers for the visualization and manipulation of synapses
Anne M Taylor
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
Neuron 66:57-68. 2010
..Here we developed a microfluidic local perfusion (microLP) chamber to access and manipulate synaptic regions and presynaptic and postsynaptic compartments in ..
- Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart
Harald C Ott
Department of Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
Nat Med 14:213-21. 2008
..We decellularized hearts by coronary perfusion with detergents, preserved the underlying extracellular matrix, and produced an acellular, perfusable vascular ..
- Normothermic ex vivo lung perfusion in clinical lung transplantation
Toronto Lung Transplant Program, University of Toronto, ON, Canada
N Engl J Med 364:1431-40. 2011
..With the use of normothermic ex vivo lung perfusion (EVLP), the retrieved donor lung can be perfused in an ex vivo circuit, providing an opportunity to reassess its ..
- Effects of topical hypotensive drugs on circadian IOP, blood pressure, and calculated diastolic ocular perfusion pressure in patients with glaucoma
Clinica Oculistica, Universita degli Studi di Brescia, Brescia, Italy
Invest Ophthalmol Vis Sci 47:2917-23. 2006
..2%, dorzolamide 2%, and latanoprost 0.005% on intraocular pressure (IOP), blood pressure (BP), and diastolic ocular perfusion pressure (DOPP), calculated as the difference between the diastolic blood pressure (DBP) and IOP.
- Pittfalls of MRI measurement of white matter perfusion based on arterial spin labeling
P van Gelderen
Advanced MRI, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1065, USA
Magn Reson Med 59:788-95. 2008
Although arterial spin labeling (ASL) MRI has been successfully applied to measure gray matter (GM) perfusion in vivo, accurate detection of white matter (WM) perfusion has proven difficult...
- Retrograde and antegrade cerebral perfusion: results in short elective arch reconstructive times
Rita Karianna Milewski
Division of Cardiovascular Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Ann Thorac Surg 89:1448-57. 2010
..Both retrograde cerebral perfusion with deep hypothermic circulatory arrest (RCP/DHCA) and antegrade cerebral perfusion with moderate hypothermic ..
- Role of perfusion CT in assessing tumor blood flow and malignancy level of gastric cancer
Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chuo Ku, Chiba, Japan
Dig Surg 27:253-60. 2010
Intratumoral hemodynamics or tumor perfusion is useful in understanding the pathological background of the cancer. A parameter for a non-invasive, preoperative assessment of tumor perfusion has yet to be developed.
- Computed tomography and magnetic resonance perfusion imaging in ischemic stroke: definitions and thresholds
Krishna A Dani
Department of Neurology, Institute of Neurological Sciences, University of Glasgow Southern General Hospital, Glasgow, Scotland
Ann Neurol 70:384-401. 2011
Cerebral perfusion imaging with computed tomography (CT) or magnetic resonance (MR) is widely available. The optimum perfusion values to identify tissue at risk of infarction in acute stroke are unclear...
- Video rate optoacoustic tomography of mouse kidney perfusion
Institute for Biological and Medical Imaging, Technische Universität München und Helmholtz Zentrum München, Ingoldstädter Landstrasse 1, 85764 Neuherberg, Germany
Opt Lett 35:2475-7. 2010
..The previously undocumented capacity of whole-body optoacoustic tomography at a video rate has been demonstrated by visualizing mouse kidney perfusion using Indocyanine Green in vivo.
- Myocardial perfusion imaging is feasible for infarct size quantification in mice using a clinical single-photon emission computed tomography system equipped with pinhole collimators
Department of Nuclear Medicine, University of Munich, Munich, Germany
Mol Imaging Biol 12:427-34. 2010
The aim of this study is to evaluate a non-invasive method for measuring myocardial perfusion defect size in mice using a clinical single-photon emission computed tomography system equipped with pinhole collimators (pinhole SPECT).
- In vivo Gd-DTPA concentration for MR lung perfusion measurements: assessment with computed tomography in a porcine model
Department of Radiology, German Cancer Research Center, Heidelberg, Germany
Eur Radiol 18:2102-7. 2008
..MR signal and contrast-agent concentration (CAC) of the arterial-input function (AIF) is crucial for MR lung-perfusion quantification...
- Assessment of differential pulmonary blood flow using perfusion magnetic resonance imaging: comparison with radionuclide perfusion scintigraphy
Department of Radiological Sciences, Catholic University of Rome, Rome, Italy
Invest Radiol 41:624-30. 2006
We sought to assess the agreement between lung perfusion ratios calculated from pulmonary perfusion magnetic resonance imaging (MRI) and those calculated from radionuclide (RN) perfusion scintigraphy.
- Do acute diffusion- and perfusion-weighted MRI lesions identify final infarct volume in ischemic stroke?
C S Rivers
Division of Clinical Neurosciences, Western General Hospital, Edinburgh, EH4 2XU, UK
Stroke 37:98-104. 2006
An acute mismatch on diffusion-weighted MRI (DWI) and perfusion-weighted MRI (PWI) may represent the "tissue-at-risk...
- Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion
Jeffrey S Scehnet
Department of Pathology, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA, USA
Blood 109:4753-60. 2007
..thin caliber, a markedly reduced vessel lumen, markedly reduced pericyte recruitment, and deficient vascular perfusion. sDll4 similarly induced defective vascular response in tumor implants leading to reduced tumor growth...
- Implementation of quantitative perfusion imaging techniques for functional brain mapping using pulsed arterial spin labeling
E C Wong
Department of Radiology, University of California, San Diego, La Jolla 92037 7756, USA
NMR Biomed 10:237-49. 1997
We describe here experimental considerations in the implementation of quantitative perfusion imaging techniques for functional MRI using pulsed arterial spin labeling...
- Perfusion CT: a worthwhile enhancement?
K A Miles
Southernex Imaging Group, Wesley Hospital, Chasely Street, Auchenflower, Queensland 4066, Australia
Br J Radiol 76:220-31. 2003
- EANM/ESC procedural guidelines for myocardial perfusion imaging in nuclear cardiology
Department of Clinical Physiology and Nuclear Medicine, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark
Eur J Nucl Med Mol Imaging 32:855-97. 2005
The European procedural guidelines for radionuclide imaging of myocardial perfusion and viability are presented in 13 sections covering patient information, radiopharmaceuticals, injected activities and dosimetry, stress tests, imaging ..
- Magnetic resonance quantification of the myocardial perfusion reserve with a Fermi function model for constrained deconvolution
Department of Radiology, University of Minnesota Medical School, Minneapolis 55455, USA
Med Phys 25:73-84. 1998
The myocardial perfusion reserve, defined as the ratio of hyperemic and basal myocardial blood flow, is a useful indicator of the functional significance of a coronary artery lesion...
- Machine perfusion or cold storage in deceased-donor kidney transplantation
Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
N Engl J Med 360:7-19. 2009
Static cold storage is generally used to preserve kidney allografts from deceased donors. Hypothermic machine perfusion may improve outcomes after transplantation, but few sufficiently powered prospective studies have addressed this ..
- Longitudinal MRI study of cortical thickness, perfusion, and metabolite levels in major depressive disorder
Department of Radiology, Aalborg Hospital Aarhus University Hospital, Denmark
Acta Psychiatr Scand 124:435-46. 2011
- Hypothermic machine preservation in human liver transplantation: the first clinical series
J V Guarrera
Center for Liver Disease and Transplantation, Department of Surgery, Columbia University Medical Center, New York, NY, USA
Am J Transplant 10:372-81. 2010
Hypothermic machine perfusion (HMP) is widely used to preserve kidneys for transplantation with improved results over cold storage (CS)...
- Regeneration and orthotopic transplantation of a bioartificial lung
Harald C Ott
Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Nat Med 16:927-33. 2010
..Creation of a bioartificial lung requires engineering of viable lung architecture enabling ventilation, perfusion and gas exchange...
- Perfusion-based microfluidic device for three-dimensional dynamic primary human hepatocyte cell culture in the absence of biological or synthetic matrices or coagulants
Vasiliy N Goral
Science and Technology, Corning Incorporated, Corning, New York 14831 0001, USA
Lab Chip 10:3380-6. 2010
We describe a perfusion-based microfluidic device for three-dimensional (3D) dynamic primary human hepatocyte cell culture...
- Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix
Basak E Uygun
Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Nat Med 16:814-20. 2010
..network, allowing efficient recellularization of the liver matrix with adult hepatocytes and subsequent perfusion for in vitro culture...
- Comparing kidney perfusion using noncontrast arterial spin labeling MRI and microsphere methods in an interventional swine model
Nathan S Artz
Department of Medical Physics, Wisconsin Institute for Medical Research, University of Wisconsin Madison, 1111 Highland Ave, Madison, WI 53705, USA
Invest Radiol 46:124-31. 2011
..of a flow-sensitive alternating inversion recovery-arterial spin labeling (FAIR-ASL) technique to track renal perfusion changes during pharmacologic and physiologic alterations in renal blood flow using microspheres as a gold ..
- Protective mechanisms of end-ischemic cold machine perfusion in DCD liver grafts
Swiss HPB and Transplant Center, Department of Surgery, University Hospital Zurich, Switzerland
J Hepatol 58:278-86. 2013
The aim of this study was to identify protective mechanisms of cold machine perfusion in liver grafts donated after cardiac death.
- Perfusion network shift during seizures in medial temporal lobe epilepsy
Karen M Sequeira
Comprehensive Epilepsy Center, Division of Neurology, Department of Neurosciences, Medical University of South Carolina, Charleston, SC, USA
PLoS ONE 8:e53204. 2013
..to static structural limbic compromise, it is unknown whether the limbic system undergoes dynamic regional perfusion network alterations during seizures. In this study, we aimed to investigate state specific (i.e...
- Influence of perfusion on hepatic MR diffusion measurement
K G Hollingsworth
University Department of Radiology, University of Cambridge, Addenbrookes Hospital, Cambridge CB2 2QQ, UK
NMR Biomed 19:231-5. 2006
..The factors that influence hepatic diffusion measurements are complex and are thought to include hepatic perfusion. This study assesses whether hepatic diffusion measurements are influenced by hepatic perfusion changes as this ..
- Bolus delay and dispersion in perfusion MRI: implications for tissue predictor models in stroke
Radiology and Physics Unit, UCL Institute of Child Health, University College London, London, UK
Magn Reson Med 55:1180-5. 2006
b>Perfusion maps, which are calculated from dynamic-susceptibility contrast (DSC)-MRI data by deconvolution of the arterial input function (AIF), are commonly used to predict tissue infarction in acute stroke...
- Autologous bone marrow cell transplantation increases leg perfusion and reduces amputations in patients with advanced critical limb ischemia due to peripheral artery disease
Department of Medicine, Franziskuskrankenhaus, Berlin Vascular Center, Berlin, Germany
Cell Transplant 18:371-80. 2009
..7 x 10(9)). Limb salvage was 59% at 6 months and 53% at last follow-up (mean 411 +/- 261 days, range 175-1186). Perfusion measured with ankle-brachial index (ABI) and transcutaneous oxygen tension (tcpO(2)) at baseline and after 6 ..
- Cerebral blood perfusion changes in multiple sclerosis
Institute of Neuroimmunology, Charite Universitatsmedizin Berlin, Germany
J Neurol Sci 259:16-20. 2007
..Until recently, the detection of cerebral blood perfusion changes was technically challenging, and perfusion studies in multiple sclerosis patients yielded contradictory ..
- Diffusion-weighted imaging of the prostate and rectal wall: comparison of biexponential and monoexponential modelled diffusion and associated perfusion coefficients
S F Riches
MRI Unit, Royal Marsden NHS Foundation Trust, Surrey, UK
NMR Biomed 22:318-25. 2009
..giving an apparent diffusion coefficient (ADC) from the monoexponential model and a diffusion coefficient, perfusion coefficient and perfusion fraction from the biexponential model...
- Mild therapeutic hypothermia for postischemic vasoconstriction in the perfused rat liver
H A Zar
Safar Center for Resuscitation Research and the Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh School of Medicine, Pennsylvania, USA
Anesthesiology 90:1103-11. 1999
..a promising therapy being evaluated for various clinical situations, may suppress the formation of reactive oxygen species during reperfusion and may ameliorate microcirculatory perfusion failure (the "no-reflow phenomenon").
- First-pass perfusion CMR two days after infarction predicts severity of functional impairment six weeks later in the rat heart
Daniel J Stuckey
Department of Physiology, Anatomy and Genetics, University of Oxford, UK
J Cardiovasc Magn Reson 13:38. 2011
..In order to identify perfusion delays in the infarcted rat heart, here we present a method in which a T1 weighted MR image has been acquired ..
- Diagnostic performance of noninvasive myocardial perfusion imaging using single-photon emission computed tomography, cardiac magnetic resonance, and positron emission tomography imaging for the detection of obstructive coronary artery disease: a meta-anal
Department of Cardiology, Maastricht University Medical Center, Maastricht, The Netherlands
J Am Coll Cardiol 59:1719-28. 2012
This study aimed to determine the diagnostic accuracy of the 3 most commonly used noninvasive myocardial perfusion imaging modalities, single-photon emission computed tomography (SPECT), cardiac magnetic resonance (CMR), and positron ..
- Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing
Rui M Tostões
ITQB UNL, Oeiras, Portugal
Hepatology 55:1227-36. 2012
..In this work, an automated perfusion bioreactor was used to obtain and maintain human hepatocyte spheroids...
- Quantitative MR evaluation of atrophy, as well as perfusion and diffusion alterations within hippocampi in patients with Alzheimer's disease and mild cognitive impairment
Department of General and Interventional Radiology, and Neuroradiology, Wroclaw Medical University, Wroclaw, Poland
Med Sci Monit 19:86-94. 2013
The aim of this study was to evaluate atrophy rates, perfusion, and diffusion disturbances within the hippocampus, which is the site of characteristic changes in Alzheimer's disease (AD) and mild cognitive impairment (MCI).
- Bilateral versus unilateral antegrade cerebral perfusion in arch reconstruction for aortic dissection
Shanghai Institute of Cardiovascular Disease, Department of Cardiovascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
Ann Thorac Surg 93:1917-20. 2012
The superiority of bilateral versus unilateral antegrade cerebral perfusion (ACP) has been the subject of much debate. This study aimed to compare the two methods of cerebral perfusion.
- Quantitation of renal perfusion using arterial spin labeling with FAIR-UFLARE
Klinikum an der CAU zu Kiel, Klinik für Diagnostische Radiologie, Michaelisstr 9, 24105, Kiel, Germany
Magn Reson Imaging 18:641-7. 2000
Quantitative perfusion imaging of human kidneys was performed using arterial spin labeling MRI with a fast spin echo readout-sequence. Perfusion maps of centrally located single slices were obtained in axial and coronal orientations...
- Autonomic modulation of electrical restitution, alternans and ventricular fibrillation initiation in the isolated heart
G Andre Ng
Cardiology Group, Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom
Cardiovasc Res 73:750-60. 2007
..We examined the effects of direct sympathetic (SS) and vagus (VS) nerve stimulation on electrical restitution, alternans and VF threshold (VFT) in a novel isolated rabbit heart preparation with intact dual autonomic innervation...
- Pulsed star labeling of arterial regions (PULSAR): a robust regional perfusion technique for high field imaging
Department of Neuroradiology, National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore 308433
Magn Reson Med 53:15-21. 2005
Regional perfusion imaging (RPI) has recently been introduced as a potentially powerful technique to map the perfusion territories of patients with vascular diseases in a fully noninvasive manner...
- Arterial spin labeling perfusion fMRI with very low task frequency
Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Magn Reson Med 49:796-802. 2003
..By contrast, drift effects are minimized in arterial spin labeling (ASL) perfusion contrast, primarily as a result of successive pairwise subtraction between images acquired with and without ..
- The role of dynamic instability and wavelength in arrhythmia maintenance as revealed by panoramic imaging with blebbistatin vs. 2,3-butanedione monoxime
Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130 4899, USA
Am J Physiol Heart Circ Physiol 302:H262-9. 2012
..This relatively high dynamic instability leads to the self-termination of arrhythmia because of the sufficiently long wavelength under blebbistatin...
- Pediatric perfusion imaging using pulsed arterial spin labeling
Department of Radiology, University of Pennsylvania, Philadelphia 19104, USA
J Magn Reson Imaging 18:404-13. 2003
To test the feasibility of pediatric perfusion imaging using a pulsed arterial spin labeling (ASL) technique at 1.5 T.
- Heterogeneity of pulmonary perfusion as a mechanistic image-based phenotype in emphysema susceptible smokers
Sara K Alford
Departmentsof Radiology, University of Iowa, Iowa City, IA 52242, USA
Proc Natl Acad Sci U S A 107:7485-90. 2010
..We sought to test the hypothesis, via multidetector row CT (MDCT) perfusion imaging, that smokers showing early signs of emphysema susceptibility have a greater heterogeneity in regional ..
- Ex-vivo normothermic liver perfusion: an update
Nuffield Department of Surgery, Oxford Transplant Centre, University of Oxford, Oxford, UK
Curr Opin Organ Transplant 15:167-72. 2010
..In the case of the liver, a substantial number of organs are discarded because of a risk of primary nonfunction...
- Atrioventricular conduction with and without AV nodal delay: two pathways to the bundle of His in the rabbit heart
William J Hucker
Biomedical Engineering Department, Washington University, 1 Brookings Drive, St Louis, MO 63130, USA
Am J Physiol Heart Circ Physiol 293:H1122-30. 2007
..In conclusion, optical maps and S-H intervals for SP/His activation suggest that AV conduction via SP bypasses the compact AV node via the lower nodal bundle, which may be utilized to achieve long-term ventricular synchronization...
- Application of perfusion culture system improves in vitro and in vivo osteogenesis of bone marrow-derived osteoblastic cells in porous ceramic materials
Age Dimension Research Center, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki, Japan
Tissue Eng 9:1205-14. 2003
..b>Perfusion culture has potential utility for many cell types in three-dimensional (3D) culture...
- 3-D computational modeling of media flow through scaffolds in a perfusion bioreactor
Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 315 Ferst Dr NW, Atlanta, GA 30332, USA
J Biomech 38:543-9. 2005
Media perfusion bioreactor systems have been developed to improve mass transport throughout three-dimensional (3-D) tissue-engineered constructs cultured in vitro...
- Chronic mild reduction of cerebral perfusion pressure induces ischemic tolerance in focal cerebral ischemia
Division of Strokology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
Stroke 36:2270-4. 2005
..We focused on collateral development after mild reduction of perfusion pressure to find an endogenous response of the vascular system that contributes to development of ischemic ..
- The potential of ferumoxytol nanoparticle magnetic resonance imaging, perfusion, and angiography in central nervous system malignancy: a pilot study
Edward A Neuwelt
Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
Neurosurgery 60:601-11; discussion 611-2. 2007
..Our objectives were to determine the optimum time of delayed contrast enhancement of ferumoxytol, and to compare ferumoxytol and gadolinium contrast agents for magnetic resonance angiography and perfusion.
- Determination of comprehensive arterial blood inflow in abdominal-pelvic organs: impact of respiration and posture on organ perfusion
Department of Sports Medicine for Health Promotion, Tokyo Medical University, Tokyo, Japan
Med Sci Monit 17:CR57-66. 2011
..However, little information exists regarding the influence of respiration (interplay between inspiration and expiration) and posture on BFAP...
- Preservation of steatotic livers: a comparison between cold storage and machine perfusion preservation
Surgical Laboratory, Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands
Liver Transpl 13:497-504. 2007
..Hypothermic machine perfusion (MP) has been introduced for preservation of donor livers instead of cold storage (CS), resulting in superior ..
- Subnormothermic machine perfusion protects steatotic livers against preservation injury: a potential for donor pool increase?
Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
Liver Transpl 15:20-9. 2009
We tested whether rat liver preservation performed by machine perfusion (MP) at 20 degrees C can enhance the functional integrity of steatotic livers versus simple cold storage...
- Perfusion CT of the brain using 40-mm-wide detector and toggling table technique for initial imaging of acute stroke
Sung Won Youn
Department of Radiology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam si 463 707, Korea
AJR Am J Roentgenol 191:W120-6. 2008
Limited coverage of the brain in the z-axis has been a drawback of perfusion CT...
- Convection perfusion of glucocerebrosidase for neuronopathic Gaucher's disease
Russell R Lonser
Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
Ann Neurol 57:542-8. 2005
..Primates underwent serial magnetic resonance imaging during enzyme perfusion of the right frontal lobe or brainstem, were observed and then sacrificed after infusion completion...
- Retrograde heart perfusion: the Langendorff technique of isolated heart perfusion
Robert M Bell
The Hatter Cardiovascular Institute, University College London Hospital and Medical School, 67 Chenies Mews, London WC1E 6HX, UK
J Mol Cell Cardiol 50:940-50. 2011
..The Langendorff perfusion apparatus is highly adaptable and this is reflected not only in the procedure's longevity but also in the number ..
- Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion-diffusion weighted imaging or perfusion CT (DIAS-2): a prospective, randomised, double-blind, placebo-controlled study
Department of Neurology, University of Heidelberg, Heidelberg, Germany
Lancet Neurol 8:141-50. 2009
..activator, has clinical benefit when given 3-9 h after the onset of the symptoms of stroke in patients with presumptive tissue at risk that is identified by magnetic resonance perfusion imaging (PI) and diffusion-weighted imaging (DWI).
- Three-dimensional perfusion culture of human adipose tissue-derived endothelial and osteoblastic progenitors generates osteogenic constructs with intrinsic vascularization capacity
Department of Surgery and Research, Institute for Surgical Research and Hospital Management, University Hospital Basel, Hebelstrasse 20, CH 4031 Basel, Switzerland
Stem Cells 25:1823-9. 2007
..from human lipoaspirates were seeded and cultured for 5 days in porous hydroxyapatite scaffolds by alternate perfusion through the scaffold pores, eliminating standard monolayer (two-dimensional [2D]) culture...
- Oscillatory shear stress stimulates endothelial production of O2- from p47phox-dependent NAD(P)H oxidases, leading to monocyte adhesion
Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30322, USA
J Biol Chem 278:47291-8. 2003
- Machine perfusion versus cold storage for preservation of kidneys from expanded criteria donors after brain death
Clinic for General, Visceral and Transplantation Surgery, University Hospital Essen, Hufelandstrasse 55, Germany
Transpl Int 24:548-54. 2011
The purpose of this study was to analyze the possible effects of machine perfusion (MP) versus cold storage (CS) on delayed graft function (DGF) and early graft survival in expanded criteria donor kidneys (ECD)...
- Advantages of normothermic perfusion over cold storage in liver preservation
Charles J Imber
Nuffield Department of Surgery, Oxford University, Oxford, United Kingdom
Transplantation 73:701-9. 2002
..we have used an extracorporeal circuit to preserve the liver with normothermic, oxygenated, sanguineous perfusion. In this study, we directly compared preservation by the standard method of simple cold storage in University of ..
- The third gas: H2S regulates perfusion pressure in both the isolated and perfused normal rat liver and in cirrhosis
Dipartimento di Medicina Clinica, Patologia, Clinica di Gastroenterologia ed Endoscopia Digestiva, University of Perugia, Perugia, Italy
Hepatology 42:539-48. 2005
..The reduction of CSE expression in the liver with cirrhosis contributes to the development of increased intrahepatic resistance and portal hypertension...
- Penetrating arterioles are a bottleneck in the perfusion of neocortex
Department of Physics, University of California at San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 104:365-70. 2007
..We conclude that penetrating arterioles are a bottleneck in the supply of blood to neocortex, at least to superficial layers...
- Evidence for intestinal and liver epithelial cell injury in the early phase of sepsis
Joep P M Derikx
Department of Surgery, University Hospital Maastricht and Nutrition and Toxicology Research Institute NUTRIM, Maastricht University, Maastricht, The Netherlands
Shock 28:544-8. 2007
..Our aim was to study (1) the relation between intramucosal perfusion and intestinal and hepatic cell damage in an early phase of sepsis and (2) the correlation of these parameters ..
- Diffusion and perfusion MRI: basic physics
MR-Centre, Academisch Ziekenhuis, , Laarbeeklaan 101, 1090, Brussels, Belgium
Eur J Radiol 38:19-27. 2001
Diffusion and perfusion MR imaging are now being used increasingly in neuro-vascular clinical applications...
- Isolated heart perfusion according to Langendorff---still viable in the new millennium
Department of Pharmacology, Medical University Wroclaw, Wroclaw, Poland
J Pharmacol Toxicol Methods 55:113-26. 2007
..In the last decade the method has brought many important advances in many areas including ischemia-reperfusion injury, cell-based therapy and donor heart preservation for transplant...
- Maintaining network activity in submerged hippocampal slices: importance of oxygen supply
Department of Cellular and Network Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u 43, 1083 Budapest, Hungary
Eur J Neurosci 29:319-27. 2009
..These improvements to the recording conditions enable detailed studies of neurons under more realistic conditions of network activity, which are essential for a better understanding of neuronal network operation...
- Advanced hepatocellular carcinoma: CT perfusion of liver and tumor tissue--initial experience
Dushyant V Sahani
Department of Abdominal Imaging and Interventional Radiology, Massachusetts General Hospital, 55 Fruit St, White 270, Boston, MA 02114, USA
Radiology 243:736-43. 2007
To prospectively assess computed tomographic (CT) perfusion for evaluation of tumor vascularity of advanced hepatocellular carcinoma (HCC) and to correlate CT perfusion parameters with tumor grade and serum markers.
- Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood-brain barrier: An in situ cerebral perfusion study
Laval University, Quebec, QC, Canada
Neurochem Int 55:476-82. 2009
..Here, using an in situ brain perfusion technique in mice, we show that [(14)C]-DHA and [(14)C]-EPA readily cross the mouse blood-brain barrier (BBB) ..
- Decellularized tissue-engineered blood vessel as an arterial conduit
Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA
Proc Natl Acad Sci U S A 108:9214-9. 2011
..grown from banked porcine smooth muscle cells that were allogeneic to the intended recipient, using a biomimetic perfusion system...
- Hemorrhagic transformation of ischemic stroke: prediction with CT perfusion
Richard I Aviv
Division of Neuroradiology, Sunnybrook Health Science Centre, Toronto, Ontario, Canada
Radiology 250:867-77. 2009
To determine whether admission computed tomography (CT) perfusion-derived permeability-surface area product (PS) maps differ between patients with hemorrhagic acute stroke and those with nonhemorrhagic acute stroke.
- Intestinal permeability of chlorpyrifos using the single-pass intestinal perfusion method in the rat
Thomas J Cook
Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
Toxicology 184:125-33. 2003
..of chlorpyrifos (CPF), an organothiophosphate pesticide, was investigated using the single-pass intestinal perfusion (SPIP) technique in male, Sprague-Dawley rats...
- Glucose-stimulated insulin secretion is coupled to the interaction of actin with the t-SNARE (target membrane soluble N-ethylmaleimide-sensitive factor attachment protein receptor protein) complex
Debbie C Thurmond
Department of Biochemistry and Molecular Biology, Center for Diabetes Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Mol Endocrinol 17:732-42. 2003
- Effects of medium perfusion rate on cell-seeded three-dimensional bone constructs in vitro
Sarah H Cartmell
School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
Tissue Eng 9:1197-203. 2003
..This study examined the effects of medium perfusion rate on cell viability, proliferation, and gene expression within cell-seeded 3D bone scaffolds...
- Evidence that hypoxia markers detect oxygen gradients in liver: pimonidazole and retrograde perfusion of rat liver
G E Arteel
Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill 27599, USA
Br J Cancer 72:889-95. 1995
..To answer this question, the binding patterns of the 2-nitroimidazole, pimonidazole, were compared following perfusion of surgically isolated rat livers in anterograde and retrograde directions...
- A working heart-brainstem preparation of the mouse
J F Paton
Department of Physiology, School of Medical Sciences, University of Bristol, UK
J Neurosci Methods 65:63-8. 1996
..The WH-BP may provide an advantaged environment for analysis of both synaptic and cellular mechanisms within the medulla that regulate cardio-respiratory activity...
- Arterial spin labeling in combination with a look-locker sampling strategy: inflow turbo-sampling EPI-FAIR (ITS-FAIR)
Deutsches Krebsforschungszentrum DKFZ, Forschungsschwerpunkt Radiologische Diagnostik und Therapie E0201, Heidelberg, Germany
Magn Reson Med 46:974-84. 2001
Arterial spin labeling (ASL) permits quantification of tissue perfusion without the use of MR contrast agents...
- Tissue-engineered vascular grafts composed of marine collagen and PLGA fibers using pulsatile perfusion bioreactors
Sung In Jeong
School of Chemical Engineering, College of Engineering, Hanyang University, Seoul 133 791, Republic of Korea
Biomaterials 28:1115-22. 2007
..The pulsatile perfusion system enhanced the SMCs and ECs proliferation...
- Spatiotemporal dynamics of diffusional kurtosis, mean diffusivity and perfusion changes in experimental stroke
Edward S Hui
Research Imaging Institute, University of Texas Health Science Center at San Antonio, TX, USA
Brain Res 1451:100-9. 2012
..The current study showed that DKI has the potential to complement existing stroke imaging techniques, particularly in the assessment of subacute to early chronic stroke evolution...
- Reproducibility of renal perfusion MR imaging in native and transplanted kidneys using non-contrast arterial spin labeling
Nathan S Artz
Department of Medical Physics, University of Wisconsin Madison, Wisconsin Institute for Medical Research, Madison, Wisconsin 53705 2275, USA
J Magn Reson Imaging 33:1414-21. 2011
To examine both inter-visit and intra-visit reproducibility of a MR arterial spin labeling (ASL) perfusion technique in native and transplanted kidneys over a broad range of renal function.
- Perfused multiwell plate for 3D liver tissue engineering
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
Lab Chip 10:51-8. 2010
..To address this, we have developed a bioreactor that fosters maintenance of 3D tissue cultures under constant perfusion and we have integrated multiple bioreactors into an array in a multiwell plate format...
- Reliability and precision of pseudo-continuous arterial spin labeling perfusion MRI on 3.0 T and comparison with 15O-water PET in elderly subjects at risk for Alzheimer's disease
GRECC, Madison VA Hospital, Madison, WI, USA
NMR Biomed 23:286-93. 2010
..The ICCs were greater than 0.90 in pcASL global perfusion measurements for both the young and the elderly groups...
- Development of a perfusion fed bioreactor for embryonic stem cell-derived cardiomyocyte generation: oxygen-mediated enhancement of cardiomyocyte output
Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada
Biotechnol Bioeng 90:452-61. 2005
..We developed a single-step bioprocess for ES cell-derived cardiomyocyte production that enables both medium perfusion and direct monitoring and control of dissolved oxygen...
- Quantitative analysis of transmural gradients in myocardial perfusion magnetic resonance images
G L T F Hautvast
Philips Healthcare, Imaging Systems, MR, Best, The Netherlands
Magn Reson Med 66:1477-87. 2011
Conventional quantitative assessments of myocardial perfusion analyze the temporal relation between the arterial input function and the myocardial signal intensity curves, thereby neglecting the important spatial relation between the ..
- Assessment of the severity of liver disease and fibrotic change: the usefulness of hepatic CT perfusion imaging
Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan
Oncol Rep 16:677-83. 2006
This study assessed the utility of CT perfusion for quantitative assessment of liver function and fibrosis...
- Measurement of cerebral perfusion with arterial spin labeling: Part 1. Methods
Thomas T Liu
Department of Radiology, University of California San Diego, San Diego, California 92037, USA
J Int Neuropsychol Soc 13:517-25. 2007
..Recent advances in acquisition and analysis methods have improved the somewhat limited sensitivity of ASL to perfusion changes associated with neural activity...
- Chondrogenic differentiation of human bone marrow mesenchymal stem cells in chitosan-based scaffolds using a flow-perfusion bioreactor
M L Alves da Silva
3Bs Research Group Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Avepark, Zona Industrial da Gandra, S Cláudio do Barco, 4806 909 Caldas das Taipas, Guimaraes, Portugal
J Tissue Eng Regen Med 5:722-32. 2011
..We intended to find out whether the shear stress caused by perfusion of the medium through the constructs was capable of augmenting the differentiation process...
- Clinical value of absolute quantification of myocardial perfusion with (15)O-water in coronary artery disease
Sami A Kajander
Turku PET Centre, University of Turku, Turku, Finland
Circ Cardiovasc Imaging 4:678-84. 2011
The standard interpretation of perfusion imaging is based on the assessment of relative perfusion distribution. The limitations of that approach have been recognized in patients with multivessel disease and endothelial dysfunction...
- A multiphase model for tissue construct growth in a perfusion bioreactor
R D O'Dea
School of Mathematical Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK
Math Med Biol 27:95-127. 2010
The growth of a cell population within a rigid porous scaffold in a perfusion bioreactor is studied, using a three-phase continuum model of the type presented by Lemon et al...
- Comparative effects of combretastatin A-4 disodium phosphate and 5,6-dimethylxanthenone-4-acetic acid on blood perfusion in a murine tumour and normal tissues
Danish Cancer Society, Department of Experimental Clinical Oncology, Aarhus University Hospital
Int J Radiat Biol 77:195-204. 2001
To compare the ability of combretastatin A-4 disodium phosphate (CA4DP) and 5,6-dimethylxanthenone-4-acetic acid (DMXAA) to change tissue blood perfusion.
- Optimal location for arterial input function measurements near the middle cerebral artery in first-pass perfusion MRI
Egbert J W Bleeker
Department of Radiology, C J Gorter Center for High Field MRI, Leiden University Medical Center, Leiden, The Netherlands
J Cereb Blood Flow Metab 29:840-52. 2009
One of the main difficulties in obtaining quantitative perfusion values from dynamic susceptibility contrast-magnetic resonance imaging is a correct arterial input function (AIF) measurement, as partial volume effects can lead to an ..
- Prognostic value of normal regadenoson stress perfusion cardiovascular magnetic resonance
Benjamin H Freed
Department of Medicine, University of Chicago, Chicago, IL, USA
J Cardiovasc Magn Reson 15:108. 2013
..Although extensively studied in patients undergoing nuclear perfusion imaging (MPI), its use for perfusion cardiovascular magnetic resonance (CMR) is not well described...
- A novel porous mechanical framework for modelling the interaction between coronary perfusion and myocardial mechanics
A N Cookson
Imaging Sciences and Biomedical Engineering Division, St Thomas Hospital, King s College London, SE1 7EH, UK
J Biomech 45:850-5. 2012
..tissue is a central feature of cardiac physiology and must therefore be accounted for by models of coronary perfusion. Currently available geometrically explicit vascular models fail to capture this interaction satisfactorily, are ..
- Identification of penumbra and infarct in acute ischemic stroke using computed tomography perfusion-derived blood flow and blood volume measurements
B D Murphy
University of Western Ontario, London, ON, Canada
Stroke 37:1771-7. 2006
We investigated whether computed tomography (CT) perfusion-derived cerebral blood flow (CBF) and cerebral blood volume (CBV) could be used to differentiate between penumbra and infarcted gray matter in a limited, exploratory sample of ..
- Optimization of culture conditions for osteogenically-induced mesenchymal stem cells in β-tricalcium phosphate ceramics with large interconnected channels
Max Bergmann Centre of Biomaterials and Institute for Materials Science, Technische Universitat Dresden, Germany
J Tissue Eng Regen Med 5:444-53. 2011
..bone marrow-derived MSCs were seeded into the scaffolds and cultivated for up to 3 weeks in both static and perfusion culture in the presence of osteogenic supplements (dexamethasone, β-glycerophosphate, ascorbate)...
- "Dynamic spot sign" on CT perfusion source images predicts haematoma expansion in acute intracerebral haemorrhage
Sheng jun Sun
Department of Neuroradiology, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
Eur Radiol 23:1846-54. 2013
To evaluate the association between dynamic progressive enhancing foci ("dynamic spot sign") in acute haematoma on CT perfusion source images (CTP-SI) and haematoma expansion.
- Arterial spin labelling reveals an abnormal cerebral perfusion pattern in Parkinson's disease
Tracy R Melzer
Van der Veer Institute for Parkinson s and Brain Research, Christchurch 8011, New Zealand
Brain 134:845-55. 2011
..tomography and single photon emission computed tomography studies have suggested patterns of abnormal cerebral perfusion in Parkinson's disease as potential functional biomarkers...
- Multislice perfusion of the kidneys using parallel imaging: image acquisition and analysis strategies
Alexander G Gardener
Sir Peter Mansfield Magnetic Resonance Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, UK
Magn Reson Med 63:1627-36. 2010
..recovery arterial spin labeling with parallel imaging acquisition is used to acquire single-shot, multislice perfusion maps of the kidney...
- A novel Schlemm's Canal scaffold increases outflow facility in a human anterior segment perfusion model
Lucinda J Camras
Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198 5840, USA
Invest Ophthalmol Vis Sci 53:6115-21. 2012
..An intracanalicular scaffold (Hydrus microstent) designed to reduce intraocular pressure as a glaucoma treatment was tested in human anterior segments to determine changes in outflow facility (C)...