polarization microscopy

Summary

Summary: Microscopy using polarized light in which phenomena due to the preferential orientation of optical properties with respect to the vibration plane of the polarized light are made visible and correlated parameters are made measurable.

Top Publications

  1. ncbi Changes in spatial collagen content and collagen network architecture in porcine articular cartilage during growth and maturation
    J Rieppo
    Institute of Biomedicine, Anatomy, University of Kuopio, Kuopio, Finland
    Osteoarthritis Cartilage 17:448-55. 2009
  2. ncbi Structure-function relationships in enzymatically modified articular cartilage
    Jarno Rieppo
    Department of Anatomy, University of Kuopio, Kuopio, Finland
    Cells Tissues Organs 175:121-32. 2003
  3. pmc Detecting structural changes in early experimental osteoarthritis of tibial cartilage by microscopic magnetic resonance imaging and polarised light microscopy
    H A Alhadlaq
    Department of Physics and Center for Biomedical Research, Oakland University, Rochester, MI 48309, USA
    Ann Rheum Dis 63:709-17. 2004
  4. ncbi Maturation of collagen fibril network structure in tibial and femoral cartilage of rabbits
    P Julkunen
    Department of Clinical Neurophysiology, Kuopio University Hospital, Kuopio, Finland
    Osteoarthritis Cartilage 18:406-15. 2010
  5. ncbi Orthogonal polarization spectral imaging as a tool for the assessment of hepatic microcirculation: a validation study
    S Langer
    Institute for Surgical Research, Ludwig Maximilians University Munich, University Hospital Grosshadern, Germany
    Transplantation 71:1249-56. 2001
  6. pmc Measurement of single macromolecule orientation by total internal reflection fluorescence polarization microscopy
    Joseph N Forkey
    Pennsylvania Muscle Institute and Department of Physiology, University of Pennsylvania, Philadelphia, 19104 6083, USA
    Biophys J 89:1261-71. 2005
  7. ncbi Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock
    Yasser Sakr
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Crit Care Med 32:1825-31. 2004
  8. ncbi Polarization microscopy with stellated gold nanoparticles for robust monitoring of molecular assemblies and single biomolecules
    Jesse Aaron
    Dept Biomedical Engineering, University of Texas at Austin, Austin TX 78712, USA
    Opt Express 16:2153-67. 2008
  9. ncbi FRET by fluorescence polarization microscopy
    David W Piston
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Methods Cell Biol 85:415-30. 2008
  10. ncbi Microcirculation in distress: a new resuscitation end point?
    Can Ince
    Crit Care Med 32:1963-4. 2004

Detail Information

Publications228 found, 100 shown here

  1. ncbi Changes in spatial collagen content and collagen network architecture in porcine articular cartilage during growth and maturation
    J Rieppo
    Institute of Biomedicine, Anatomy, University of Kuopio, Kuopio, Finland
    Osteoarthritis Cartilage 17:448-55. 2009
    ..The present study was designed to reveal changes in the collagen network architecture and collagen content in cartilage during growth and maturation of pigs...
  2. ncbi Structure-function relationships in enzymatically modified articular cartilage
    Jarno Rieppo
    Department of Anatomy, University of Kuopio, Kuopio, Finland
    Cells Tissues Organs 175:121-32. 2003
    ....
  3. pmc Detecting structural changes in early experimental osteoarthritis of tibial cartilage by microscopic magnetic resonance imaging and polarised light microscopy
    H A Alhadlaq
    Department of Physics and Center for Biomedical Research, Oakland University, Rochester, MI 48309, USA
    Ann Rheum Dis 63:709-17. 2004
    ..To detect changes in the collagen fibril network in articular cartilage in a canine experimental model of early osteoarthritis (OA) using microscopic magnetic resonance imaging (microMRI) and polarised light microscopy (PLM)...
  4. ncbi Maturation of collagen fibril network structure in tibial and femoral cartilage of rabbits
    P Julkunen
    Department of Clinical Neurophysiology, Kuopio University Hospital, Kuopio, Finland
    Osteoarthritis Cartilage 18:406-15. 2010
    ..These changes modulate the functional properties of cartilage. We studied maturation-related changes in the collagen network organization of cartilage as a function of tissue depth...
  5. ncbi Orthogonal polarization spectral imaging as a tool for the assessment of hepatic microcirculation: a validation study
    S Langer
    Institute for Surgical Research, Ludwig Maximilians University Munich, University Hospital Grosshadern, Germany
    Transplantation 71:1249-56. 2001
    ..However, before implementation into clinical use its ability to quantitatively measure microcirculatory parameters must be validated...
  6. pmc Measurement of single macromolecule orientation by total internal reflection fluorescence polarization microscopy
    Joseph N Forkey
    Pennsylvania Muscle Institute and Department of Physiology, University of Pennsylvania, Philadelphia, 19104 6083, USA
    Biophys J 89:1261-71. 2005
    ..In addition to evaluating the technique, the data also provide a new measurement of the torsional rigidity of F-actin. These measurements support the smaller of two values of the torsional rigidity of F-actin previously reported...
  7. ncbi Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock
    Yasser Sakr
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Crit Care Med 32:1825-31. 2004
    ..To characterize the time course of microcirculatory alterations and their relation to outcome in patients with septic shock...
  8. ncbi Polarization microscopy with stellated gold nanoparticles for robust monitoring of molecular assemblies and single biomolecules
    Jesse Aaron
    Dept Biomedical Engineering, University of Texas at Austin, Austin TX 78712, USA
    Opt Express 16:2153-67. 2008
    ..The imaging can be carried out with single molecule sensitivity for essentially unlimited time with no signal degradation...
  9. ncbi FRET by fluorescence polarization microscopy
    David W Piston
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Methods Cell Biol 85:415-30. 2008
    ..In this chapter, we will discuss the theory behind AFRET imaging, calculation of FP anisotropies using fluorescent microscopes, and configuration of microscopes for AFRET experiments...
  10. ncbi Microcirculation in distress: a new resuscitation end point?
    Can Ince
    Crit Care Med 32:1963-4. 2004
  11. pmc High-contrast imaging of fluorescent protein FRET by fluorescence polarization microscopy
    Mark A Rizzo
    Biophys J 88:L14-6. 2005
    ..This approach is able to distinguish FRET between linked and unlinked Cerulean and Venus fluorescent proteins in living cells with a larger dynamic range than other approaches...
  12. ncbi Anisotropy of collagen fibre alignment in bovine cartilage: comparison of polarised light microscopy and spatially resolved diffusion-tensor measurements
    S K de Visser
    School of Physical and Chemical Sciences, Queensland University of Technology, Brisbane, QLD, Australia
    Osteoarthritis Cartilage 16:689-97. 2008
    ..To compare collagen fibre alignment angles obtained from polarised light microscopy (PLM) and diffusion-tensor imaging (DTI) in bovine articular cartilage...
  13. ncbi Modeling optical behavior of birefringent biological tissues for evaluation of quantitative polarized light microscopy
    Mark C van Turnhout
    Wageningen University, Department of Animal Sciences, Experimental Zoology Group, P O Box 338, Wageningen, 6700 AH, The Netherlands
    J Biomed Opt 14:054018. 2009
    ..Because collagen fiber orientation and anisotropy are important for tissue function, these results can improve the biological and medical relevance of qPLM results...
  14. ncbi Microvascular blood flow is altered in patients with sepsis
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium
    Am J Respir Crit Care Med 166:98-104. 2002
    ..The topical application of acetylcholine totally reversed these alterations. In conclusion, microvascular blood flow alterations are frequent in patients with sepsis and are more severe in patients with a worse outcome...
  15. pmc Long-term cyclical in vivo loading increases cartilage proteoglycan content in a spatially specific manner: an infrared microspectroscopic imaging and polarized light microscopy study
    Ehsan Saadat
    Department of Bioengineering, University of California, Berkeley, 459 Evans Hall 1762 Berkeley, CA 94720 1762, USA
    Arthritis Res Ther 8:R147. 2006
    ..Furthermore, stimulation is localized to cartilage regions of high hydrostatic pressure. These data may be useful in developing interventions to prevent overuse injuries or in developing therapies to improve joint function...
  16. ncbi Effect of loading on the organization of the collagen fibril network in juvenile equine articular cartilage
    Pieter A J Brama
    School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland
    J Orthop Res 27:1226-34. 2009
    ..The site differences in OI indicate that Benninghoff's classic predominantly perpendicular arcades appear not to be a consistent architectural feature, but adapt to local forces sustained...
  17. ncbi Age matters: collagen birefringence of superficial articular cartilage is increased in young guinea-pigs but decreased in older animals after identical physiological type of joint loading
    M M Hyttinen
    Department of Anatomy, University of Kuopio, Finland
    Osteoarthritis Cartilage 9:694-701. 2001
    ..It can be hypothesized further that with time the inferior property of the collagen network predisposes the older runners to earlier OA than in controls...
  18. pmc Orientation of the myosin light chain region by single molecule total internal reflection fluorescence polarization microscopy
    Margot E Quinlan
    Pennsylvania Muscle Institute, University of Pennsylvania, Philadelphia, 19104 6083, USA
    Biophys J 89:1132-42. 2005
    ....
  19. ncbi Articular cartilage collagen birefringence is altered concurrent with changes in proteoglycan synthesis during dynamic in vitro loading
    K Kiraly
    Department of Anatomy, University of Kuopio, Kuopio University Hospital, Finland
    Anat Rec 251:28-36. 1998
    ..In this study, we exposed articular cartilage plugs to cyclic loading and investigated the properties of collagen network and proteoglycans in different zones of the articular cartilage...
  20. ncbi Polarized light propagation in multiply scattering media exhibiting both linear birefringence and optical activity: Monte Carlo model and experimental methodology
    Michael F G Wood
    Ontario Cancer Institute, Division of Biophysics and Bioimaging, University Health Network, Toronto, Ontario M5G 2M9, Canada
    J Biomed Opt 12:014029. 2007
    ..Other scattering-independent polarization properties can be incorporated into the developed Jones N-matrix formalism, enabling quantification of the polarization effects via an accurate polarization-sensitive Monte Carlo model...
  21. ncbi Variables affecting polarization-sensitive optical coherence tomography imaging examined through the modeling of birefringent phantoms
    Bin Liu
    Department of Orthopedic Surgery, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Opt Soc Am A Opt Image Sci Vis 22:262-71. 2005
    ..A better understanding of the mechanisms that control PS-OCT imaging would be useful for interpretation of tissue images and ultimately useful to provide more diagnostic information...
  22. ncbi Perturbation and differential Monte Carlo methods for measurement of optical properties in a layered epithelial tissue model
    InSeok Seo
    University of California, Irvine, Department of Chemical Engineering and Materials Science, Irvine, California 92697, USA
    J Biomed Opt 12:014030. 2007
    ..These results provide some guidance for the design of compact fiber-based probes to determine and isolate optical properties from both epithelial and stromal layers of superficial tissues...
  23. ncbi Degree of polarization estimation in the presence of nonuniform illumination and additive Gaussian noise
    Arnaud Bénière
    Laboratoire Charles Fabry de l Institut d Optique, Univ Paris Sud, Palaiseau, France
    J Opt Soc Am A Opt Image Sci Vis 25:919-29. 2008
    ..We demonstrate the efficiency of this new estimator and compare its performance with other standard estimators as a function of the degree of nonuniformity of the illumination...
  24. ncbi Polarization-degree imaging contrast in turbid media: a quantitative study
    Hanrong Shao
    Laboratory of Optical Imaging and Sensing, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China
    Appl Opt 45:4491-6. 2006
    ..Different behaviors in contrast for linear and circular polarizations are compared. Contributions to the background of circular polarization degree images by backscattering, snake, and diffusive photons are examined carefully...
  25. ncbi Characterizing of tissue microstructure with single-detector polarization-sensitive optical coherence tomography
    Bin Liu
    Department of Orthopedic Surgery, Brigham and Women s Hospital, Massachusetts, USA
    Appl Opt 45:4464-79. 2006
    ..This study, along with the data in part I, advance the insights gained from PS-OCT images beyond simply determining the presence or absence of birefringence...
  26. ncbi High-visibility interferometric measurement of the diffraction phase
    Salvador Barraza-Lopez
    Department of Physics and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Opt Soc Am A Opt Image Sci Vis 24:1148-55. 2007
    ..The resulting optimized visibility allows for a precise phase determination. This setup is very stable, requiring no active elements...
  27. ncbi Characterization of dentin, enamel, and carious lesions by a polarization-sensitive optical coherence tomography system
    Yueli Chen
    Department of Electrical and Computer Engineering, University of Connecticut, Storrs, Connecticut 06269 1157, USA
    Appl Opt 44:2041-8. 2005
    ..e., the local textural features and the global structural features. This study indicates that PSOCT has the potential to be a powerful tool for research of dental formation and caries diagnosis...
  28. ncbi Corneal birefringence compensation for polarization sensitive optical coherence tomography of the human retina
    Michael Pircher
    Medical University of Vienna, Center for Biomedical Engineering and Physics, Wahringer Strasse 13, A 1090 Vienna, Austria
    J Biomed Opt 12:041210. 2007
    ..We implemented the method in a state of the art spectral domain PS-OCT system and demonstrate it in a test sample and human retina in vivo...
  29. ncbi Numerical study of the effects of scatterer sizes and distributions on multiple backscattered intensity patterns of polarized light
    Yong Deng
    Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, China
    Opt Lett 33:77-9. 2008
    ..The results show that the polarization patterns of dysplastic and normal cells have distinct differences, which might be used for identification of the morphological structure changes of cancer, dysplasia, and regeneration cells...
  30. ncbi Three-dimensional laparoscope based on the manipulation of polarized light by a cellophane half-wave plate
    Keigo Iizuka
    Department of Electrical and Computer Engineering, University of Toronto, 10 King s College Road, Toronto, Ontario, Canada M5S 3G4
    Appl Opt 44:7083-90. 2005
    ..The structure is simple, sturdy, lightweight, and its diameter is no bigger than a standard 10 mm diam laparoscope...
  31. ncbi Polarimetric imaging of subsurface tissue-numerical results
    Gnanou F Sudha
    Pondicherry Engineering College, Pondicherry 605 014, India
    J Biomed Opt 10:054014. 2005
    ..Monte Carlo simulations show that the resultant image has marked contrast up to 2.5 cm...
  32. ncbi Simultaneous false-colour imaging of birefringence, extinction and transmittance at camera speed
    W Kaminsky
    Department of Chemistry, University of Washington, Seattle, WA 98195, USA
    J Microsc 228:153-64. 2007
    ..The range of possible applications is demonstrated with examples from the fields of biology, medicine, forensics and material sciences...
  33. ncbi Complex degree of mutual polarization of biological tissue coherent images for the diagnostics of their physiological state
    Oleg V Angelsky
    J Biomed Opt 10:060502. 2005
    ..The ensemble of diagnostic criteria (skewness and kurtosis of two-dimensional distributions of complex degree of mutual polarization) of pathological changes of muscular and connective (skin derma) tissues is defined...
  34. ncbi Polarization-correlation mapping of biological tissue coherent images
    O V Angelsky
    Chernivtsi National University, 2 Kotsyubinsky Street, Chernivtsi 58012, Ukraine
    J Biomed Opt 10:064025. 2005
    ..Finally, we consider the diagnostic possibilities of investigating 2-D distributions of CDMP of images that correspond to physiologically normal and degeneratively and/or dystrophycally changed biological tissues that are being analyzed...
  35. ncbi Polarization multiplexing and demultiplexing for appearance-based modeling
    Oana G Cula
    Johnson and Johnson, CPCW, Skillman, NJ 08558, USA
    IEEE Trans Pattern Anal Mach Intell 29:362-7. 2007
    ..In addition to polarization multiplexing, we show that phase histograms from the intensity modulations can be used to estimate scene properties including the number of light sources...
  36. ncbi Utility of imaging mass spectrometry (IMS) by matrix-assisted laser desorption ionization (MALDI) on an ion trap mass spectrometer in the analysis of drugs and metabolites in biological tissues
    Dieter M Drexler
    Pharmaceutical Candidate Optimization Discovery Analytical Sciences, 5 Research Parkway, Wallingford, CT 06492, USA
    J Pharmacol Toxicol Methods 55:279-88. 2007
    ..However, the localization of test article or spatial identification of metabolites may be critical to the understanding of the mechanism of target-organ toxicity and its relevance to clinical safety...
  37. ncbi Mueller polarimetric imaging system with liquid crystals
    Blandine Laude-Boulesteix
    Laboratoire de Physique des Interfaces et des Couches Minces, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 7647, Ecole Polytechnique, 91128 Palaiseau Cedex, France
    Appl Opt 43:2824-32. 2004
    ..The optical properties of Picrosirius Red stained collagen (diattenuation, retardance, and polarizance) have been measured independently from each other between 500 and 700 nm...
  38. ncbi Remineralization of in vitro dental caries assessed with polarization-sensitive optical coherence tomography
    Robert S Jones
    University of California, Department of Preventive and Restorative Dental Sciences, San Francisco, California 94143, USA
    J Biomed Opt 11:014016. 2006
    ..This study determines that PS-OCT can image the effects of fluoride-enhanced remineralization of mild and severe early artificial in vitro caries...
  39. ncbi Transparent surface modeling from a pair of polarization images
    Daisuke Miyazaki
    Institute of Industrial Science, University of Tokyo, 4 6 1 Komaba, Meguro ku, Tokyo, Japan 153 8505
    IEEE Trans Pattern Anal Mach Intell 26:73-82. 2004
    ..e., normal position and tilted with small angle position. We also discuss the geometrical features of the object surface and propose a method for matching two sets of polarization data at identical points on the object surface...
  40. pmc Cell segmentation using coupled level sets and graph-vertex coloring
    Sumit K Nath
    MCVL, Department of Computer Science, University of Missouri Columbia, Columbia, MO 65211, USA
    Med Image Comput Comput Assist Interv 9:101-8. 2006
    ....
  41. ncbi Enhancement of hidden structures of early skin fibrosis using polarization degree patterns and Pearson correlation analysis
    Alexander P Sviridov
    National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biomed Opt 10:051706. 2005
    ..In addition, Pearson correlation analysis provides information about skin structural size and directionality...
  42. pmc Interpreting second-harmonic generation images of collagen I fibrils
    Rebecca M Williams
    Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA
    Biophys J 88:1377-86. 2005
    ..Fibrillogenesis can be resolved in immature tissue by directly imaging backward-propagating SHG. Such findings are crucial to the design and development of forthcoming diagnostic and research tools...
  43. ncbi Acousto-optic-tunable-filter-based spectropolarimetric imagers for medical diagnostic applications--instrument design point of view
    Neelam Gupta
    Army Research Laboratory, 2800 Powder Mill Road, Adelphi, Maryland 20783 1197, USA
    J Biomed Opt 10:051802. 2005
    ..We describe our concept in the development of these imagers and present new results obtained using the VNIR imager...
  44. ncbi Quantification of the wound healing using polarization-sensitive optical coherence tomography
    Jung Taek Oh
    Institute for Medical Engineering, Wonju, Kangwon, Korea 220 842
    J Biomed Opt 11:041124. 2006
    ..Our results suggest that PS-OCT may be a useful tool for visualization of collagen fiber regeneration and for quantification of various drug effects during the wound healing process...
  45. ncbi Constrained optimization of Drude's equations eliminates effects of confounding molecules for the polarimetric measurement of glucose
    Burak Güçlü
    Institute for Sensory Research, 621 Skytop Road, Syracuse, New York 13244 5290, USA
    J Biomed Opt 9:967-77. 2004
    ..The relative error was smaller than 1% in all except the low-glucose sample (1.4%). This method may prove useful in noninvasive glucose measurement in humans...
  46. ncbi Polarization contrast imaging of biological tissues by polarization-sensitive Fourier-domain optical coherence tomography
    Shuichi Makita
    Institute of Applied Physics, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8573, Japan
    Appl Opt 45:1142-7. 2006
    ..Local polarization properties are obtained by longitudinal differentiation of Jones matrix components. The layered structure of the bovine tendon and birefringence are revealed...
  47. ncbi Images of finite sized spherical particles in confocal and conventional microscopes when illuminated with arbitrary polarization
    Sanaz Alali
    Department of Electrical Engineering, Sharif University of Technology, Tehran, Iran
    Appl Opt 47:453-8. 2008
    ..Further, we find the limiting size of a particle for which it can be considered a point scatterer for a particular wavelength...
  48. ncbi Polarization color imaging system for on-line quantitative evaluation of facial skin lesions
    Heesung Kang
    Department of Biomedical Engineering, Yonsei University, Wonju, Korea
    Dermatol Surg 33:1350-6. 2007
    ..Quantitative methods have limitations for widely distributed skin lesions due to poor spatial resolution, potential skin blanching, and difficulty in relocating identical sites for subsequent measurements and analysis...
  49. ncbi Polarization effects on scatterer sizing accuracy analyzed with frequency-domain angle-resolved low-coherence interferometry
    John W Pyhtila
    Department of Biomedical Engineering, Duke University, North Carolina 27708, USA
    Appl Opt 46:1735-41. 2007
    ....
  50. ncbi Polarization-rich continuous wave direct imaging: modeling and visualization
    R S Umesh
    Department of Electrical Engineering, Indian Institute of Science, Bangalore, India
    Appl Opt 45:4344-54. 2006
    ..Simulation and experimental results verify the theoretical conclusions...
  51. ncbi Fluorescence polarization of tetracycline derivatives as a technique for mapping nonmelanoma skin cancers
    Anna N Yaroslavsky
    Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Biomed Opt 12:014005. 2007
    ..Therefore, the developed technique can provide an important new tool for image-guided cancer surgery...
  52. ncbi Polarization singularities of biological tissues images
    O V Angelsky
    Chernivtsi National University, 2 Kotsyubinsky Str, Chernivtsi, 58012, Ukraine
    J Biomed Opt 11:054030. 2006
    ..It was discovered that the process of the pathological change of the kidney tissue morphology leads to the formation of the self-similar (fractal) coordinate distribution of the polarization singularities of its image...
  53. ncbi Estimation of the degree of polarization in active coherent imagery by using the natural representation
    Philippe Refregier
    Physics and Image Processing Group, Fresnel Institute, Unité Mixte de Recherche Centre National de la Recherche Scientifique 6133, 13 397 Marseille cedex 20, France
    J Opt Soc Am A Opt Image Sci Vis 21:2292-300. 2004
    ....
  54. ncbi Comments on "A new algorithm for border description of polarized light surface microscopic images of pigmented skin lesions"
    Marco Burroni
    IEEE Trans Med Imaging 25:1655-6. 2006
    ....
  55. ncbi Improved scanning laser fundus imaging using polarimetry
    Juan M Bueno
    Laboratorio de Optica, Centro de Investigación en Otica y Nanofisica, Universidad de Murcia, Spain
    J Opt Soc Am A Opt Image Sci Vis 24:1337-48. 2007
    ..Improved visualization of features could aid in the detection, localization, and tracking of ocular disease and may be applicable in other biomedical imaging...
  56. ncbi Time-resolved backscattering of circularly and linearly polarized light in a turbid medium
    Xiaohui Ni
    Institute for Ultrafast Spectroscopy and Lasers, Department of Physics, City College of New York, Graduate School of the City University of New York, New York, New York 10031, USA
    Opt Lett 29:2773-5. 2004
    ....
  57. ncbi A new algorithm for border description of polarized light surface microscopic images of pigmented skin lesions
    Costantino Grana
    Department of Computer Engineering, University of Modena and Reggio Emilia, 41100 Modena, Italy
    IEEE Trans Med Imaging 22:959-64. 2003
    ..The efficacy of these new descriptors was tested on a data set of 510 pigmented skin lesions, composed by 85 melanomas and 425 nevi, by employing statistical methods for discrimination between the two populations...
  58. pmc Orientation-independent differential interference contrast microscopy and its combination with an orientation-independent polarization system
    Michael Shribak
    Marine Biological Laboratory, 7 MBL Street, Woods Hole, Massachusetts 02543, USA
    J Biomed Opt 13:014011. 2008
    ..Those images provide clear evidence that the proposed technique can reveal fine architecture and molecular organization in live cells without perturbation associated with staining or fluorescent labeling...
  59. ncbi Performance parameters for focusing of radial polarization
    Colin J R Sheppard
    Division of Bioengineering, National University of Singapore, Singapore
    Opt Lett 33:497-9. 2008
    ..Performance parameters are presented for high-aperture radially polarized focusing systems. These can be used for comparing the focusing performance of different optical systems, including the effect of pupil filters...
  60. ncbi Three-dimensional polarization control in microscopy
    Ayman F Abouraddy
    Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Phys Rev Lett 96:153901. 2006
    ..Controlling the relative complex weights of these azimuthal harmonics produces any desired three-dimensional state of polarization...
  61. ncbi Anisotropic properties of the enamel organic extracellular matrix
    Alexandre R do Espírito Santo
    Department of Morphology, Piracicaba Dental School, State University of Campinas, Piracicaba, Sao Paulo, Brazil
    Eur J Oral Sci 114:333-7; discussion 349-50, 382. 2006
    ..The analysis of enamel organic matrix birefringence may be used to detect the effects of genetic and environmental factors on the supramolecular orientation of enamel matrix and their effects on the structure of mature enamel...
  62. ncbi Polarized laser Doppler perfusion imaging--reduction of movement-induced artifacts
    M G D Karlsson
    Linkoping University, Department of Biomedical Engineering and Competence Centre for Non invasive Medical Measurements NIMED, Sweden
    J Biomed Opt 10:064002. 2005
    ..In conclusion, the polarized LDPI technique reduces movement artifacts and is particularly appropriate when assessing, e.g., ulcers and burns, where specular reflection is high...
  63. ncbi Influence of solid phase and formulation processing on stability of Abbott-232 tablet formulations
    J Wardrop
    Manufacturing Science and Technology, Global Pharmaceutical Operations, Abbott Laboratories, North Chicago, Illinois 60064, USA
    J Pharm Sci 95:2380-92. 2006
    ..Stability studies confirmed that both IR and extended release (ER) tablets of Abbott-232 were successfully developed for clinical trials using direct compression...
  64. ncbi The influence of povidone K17 on the storage stability of solid dispersions of nimodipine and polyethylene glycol
    Martina Maria Smikalla
    Institut fuer Pharmazeutische Technologie und Biopharmazie, Heinrich Heine Universität Duesseldorf, Germany
    Eur J Pharm Biopharm 66:106-12. 2007
    ..These results show clearly that dissolution of povidone in melted polyethylene glycol is a prerequisite in order to prevent recrystallization...
  65. ncbi Polymorphism on leflunomide: stability and crystal structures
    Daniel Vega
    Unidad de Actividad Fisica, Comision Nacional de Energia Atomica, Av Gral Paz 1499, 1650 San Martin, Buenos Aires, Argentina
    J Pharm Sci 95:1075-83. 2006
    ..pi interactions, while in form II it is given only by the former. The independent molecules in form I adopt different conformations thus allowing for a larger number of intermolecular interactions...
  66. ncbi Induced amphotropic and thermotropic ionic liquid crystallinity in phosphonium halides: "lubrication" by hydroxyl groups
    Kefeng Ma
    Department of Chemistry, Georgetown University, Washington, DC 20057 1227, USA
    Langmuir 24:2746-58. 2008
    ..Possible applications of such systems are suggested...
  67. ncbi Liquid crystal and crystal structure of octahomotetraoxacalix[4]arenes
    Shigeo Kohmoto
    Department of Applied Chemistry and Biotechnology, Faculty of Engineering, Chiba University, 1 33, Yayoi cho, Inage Ku, Chiba 263 8522, Japan
    J Org Chem 71:4509-15. 2006
    ..These phases were investigated with X-ray diffraction, differential scanning calorimetry, and polarized optical microscopy...
  68. ncbi Wavelet analysis of two-dimensional birefringence images of architectonics in biotissues for diagnosing pathological changes
    Oleg V Angelsky
    Chernivtsi National University, 2 Kotsyubinsky Street, Chernivtsi 58012, Ukraine
    J Biomed Opt 9:679-90. 2004
    ..A technique for early optical diagnosis of the appearance of these biological tissues and the course of their degenerative-dystrophic changes is proposed...
  69. ncbi Optical anisotropy of the human cornea determined with a polarizing microscope
    Richard A Bone
    Department of Physics, Florida International University, 11200 SW 8th Street, Miami, Florida 33199, USA
    Appl Opt 46:8351-7. 2007
    ..Both the angle between the optic axes and the retardance were fairly constant among the majority of samples, suggestive of uniformity in corneal structure...
  70. ncbi Vortex retarders produced from photo-aligned liquid crystal polymers
    Scott C McEldowney
    JDSU, 2789 Northpoint Parkway, Santa Rosa, CA 95407, USA
    Opt Express 16:7295-308. 2008
    ..The impact of aberrations and of vortex retarder misalignment on the PSM and OTM are presented...
  71. ncbi Crystal deposits in the human intervertebral disc: implications for disc degeneration
    Helen E Gruber
    Department of Orthopaedic Surgery, Orthopedic Research Biology, Carolinas Medical Center, Charlotte, NC 28232, USA
    Spine J 7:444-50. 2007
    ..In articular cartilage matrix, crystal deposits are associated with altered extracellular matrix (ECM) and cell phenotypic features, but crystal deposition in the human intervertebral disc has received much less attention...
  72. ncbi Polarized light imaging of white matter architecture
    Luiza Larsen
    Department of Computer Science, University College London, London WC1E 6BT, United Kingdom
    Microsc Res Tech 70:851-63. 2007
    ..The strengths and weaknesses of the method are set out...
  73. pmc Alignment maps of tissues: II. Fast harmonic analysis for imaging
    T T Tower
    Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Biophys J 81:2964-71. 2001
    ..The method is demonstrated for a porcine heart valve leaflet...
  74. ncbi Physical basis of colors seen in Congo red-stained amyloid in polarized light
    Alexander J Howie
    Department of Pathology, University College London, London, UK
    Lab Invest 88:232-42. 2008
    ..Rather than showing 'apple-green birefringence in polarized light' as often reported, Congo red-stained amyloid, when examined between crossed polarizer and analyzer, should more accurately be said to show anomalous colors...
  75. ncbi Observation of extraordinary optical activity in planar chiral photonic crystals
    Kuniaki Konishi
    Department of Applied Physics, University of Tokyo, Core Research for Evolutional Science and Technology, JST, Tokyo, Japan
    Opt Express 16:7189-96. 2008
    ..We demonstrate that in the planar chiral photonic crystal, the coupling of the normally incident light wave with low-loss waveguide and Fabry-Pérot resonance modes results in a dramatic enhancement of the optical activity...
  76. ncbi Compact spatial polariscope for light polarization state analysis
    Władysław A Woźniak
    Institute of Physics, Wrocław University of Technology, Wybrzeze Wyspiańskiego 2750 370 Wrocław, Poland
    Opt Express 16:10471-9. 2008
    ..Neither movable parts nor active elements are needed and no complicated analysis of output light should be made to calculate the desired quantities...
  77. pmc Inactivation of one allele of the type II collagen gene alters the collagen network in murine articular cartilage and makes cartilage softer
    M M Hyttinen
    Department of Anatomy, University of Kuopio, Finland
    Ann Rheum Dis 60:262-8. 2001
    ....
  78. ncbi Thirty-eight years of stone meetings in Europe
    K H Bichler
    Department of Urology, University Tübingen, Hoppe Seyler Str 3, 72076, Tubingen, Germany
    Urol Res 34:70-8. 2006
    ..in the 1970s and 1980s was focused on urinary stone analysis (X-ray diffraction, infrared spectroscopy, polarization microscopy) and standardization of these methods...
  79. ncbi Organization and distribution of intramuscular connective tissue in normal and immobilized skeletal muscles. An immunohistochemical, polarization and scanning electron microscopic study
    Tero A H Järvinen
    Department of Surgery, Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland
    J Muscle Res Cell Motil 23:245-54. 2002
    ..The structure of the intramuscular connective tissue was studied by immunohistochemistry, polarization microscopy (the crimp length and angle of the collagen fibers) and scanning electron microscope (SEM) in rat ..
  80. ncbi Improved detection of amyloid in fat pad aspiration: an evaluation of Congo red stain by fluorescent microscopy
    Tamar A Giorgadze
    Department of Pathology and Laboratory Medicine, Cytopathology and Cytometry Section, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    Diagn Cytopathol 31:300-6. 2004
    ..Congophilia with apple-green birefringence by polarization microscopy (PM) is considered diagnostic for amyloid...
  81. ncbi Fibrillogenesis in gelsolin-related familial amyloidosis
    C P Maury
    Department of Medicine, University of Helsinki, Kasarmikatu 11 13, FIN 00130 Helsinki, Finland
    Amyloid 10:21-5. 2003
    ..having sequence homology with wild-type or mutant gelsolins was monitored by Congo-red staining and polarization microscopy, negative staining electron microscopy and quantitative thioflavine-T fluorometry...
  82. ncbi Cutaneous plasma cell granuloma: report of a case with novel histologic and immunohistochemical findings
    Yu Fei Chen
    Department of Dermatology, Triservice General Hospital, Taipei Veterans General Hospital, and National Defense Medical Center, Taipei, Taiwan
    Int J Dermatol 48:409-11. 2009
    ..No vasculitis or emperipolesis was found. No foreign materials were observed by polarization microscopy, and no organisms could be identified by periodic acid-Schiff (PAS), Grocott methenamine silver (GMS), ..
  83. ncbi [Relationship between corneal neovascularization and various relevant biological factors in surrounding cornea stroma of rats]
    Ting Wang
    Shandong Eye Institute, Qingdao 266071, China
    Zhonghua Yan Ke Za Zhi 45:158-63. 2009
    ..To study the relationship between corneal neovascularization and various biological factors in corneal stroma of rats...
  84. ncbi Optical anisotropy of alcian blue-stained acid glycosaminoglycans
    Maria Luiza S Mello
    Department of Cell Biology, Institute of Biology, State University of Campinas UNICAMP, 13083 863 Campinas, Brazil
    Acta Histochem 109:78-85. 2007
    ..colors of alcian blue (AB)-stained glycosaminoglycans (GAG) and glycoconjugates observed with polarization microscopy have been found to vary, although their staining characteristics under unpolarized light are practically ..
  85. ncbi Sensitivity and specificity of Congo red staining according to Romhányi. Comparison with Puchtler's or Bennhold's methods
    Miklós Bély
    Department of Pathology, Policlinic of the Hospitaller Brothers of St John of God, Frankel L 17 19, H 1027 Budapest, Hungary
    Acta Histochem 108:175-80. 2006
    ..The binding of the oriented dye molecules is optimal for polarization microscopy. With this method, the polar hydrophilic mounting medium, gum Arabic is used...
  86. pmc Distinct structural and mechanical properties of the nuclear lamina in Hutchinson-Gilford progeria syndrome
    Kris Noel Dahl
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 103:10271-6. 2006
    ..Based on polarization microscopy results, we suggest that the lamins are disordered in the healthy nuclei, whereas the lamins in HGPS ..
  87. ncbi Detection of gold particles in the neck skin after lightning stroke with evaporation of an ornamental chain
    Ludwig Jonas
    Department of Pathology, Electron Microscopic Centre, Faculty of Medicine, University of Rostock, Germany
    Ultrastruct Pathol 26:153-9. 2002
    ..and elongated gold deposits represent crystals of gold salts, as detected by electron diffraction and polarization microscopy. Attempts to remove the gold particles from the skin to remove the tattoo should not be undertaken ..
  88. ncbi Prevalence and origin of amyloid in kidney biopsies
    Hanna von Hutten
    Department of Pathology, Charite University Hospital, D 10117 Berlin, Germany
    Am J Surg Pathol 33:1198-205. 2009
    ..Amyloid was identified by Congo red staining and polarization microscopy. Immunohistochemical classification was made with antibodies directed against AA amyloid, apolipoprotein ..
  89. ncbi Relationship between meiotic spindle location with regard to the polar body position and oocyte developmental potential after ICSI
    L Rienzi
    Centre for Reproductive Medicine, European Hospital, Rome, Italy
    Hum Reprod 18:1289-93. 2003
    The recent development of a computer-assisted polarization microscopy system (Polscope) with which the meiotic spindle can be visualized in living oocytes on the basis of its birefringence permits analysis of the meiotic spindles of ..
  90. pmc Management of hyperuricemia in gout: focus on febuxostat
    Mattheus K Reinders
    Clinical Pharmacy, Atrium Medisch Centrum Parkstad, Heerlen, The Netherlands
    Clin Interv Aging 5:7-18. 2010
    ..common inflammatory arthritis in an elderly population, and can be diagnosed with absolute certainty by polarization microscopy. However, diagnosis may be challenging because atypical presentations are more common in the elderly...
  91. pmc Chondrocyte phenotype and ectopic ossification in collagenase-induced tendon degeneration
    Pauline Po Yee Lui
    Department of Orthopaedics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
    J Histochem Cytochem 57:91-100. 2009
    ..viva CT imaging and polarization microscopy showed characteristic bony porous structures and collagen fiber arrangement, respectively, in the ..
  92. ncbi Impact of gentamicin-supplemented polyvinylidenfluoride mesh materials on MMP-2 expression and tissue integration in a transgenic mice model
    Marcel Binnebösel
    Department of Surgery, RWTH Aachen University Hospital, Pauwelsstr 30, 52074, Aachen, Germany
    Langenbecks Arch Surg 395:413-20. 2010
    ....
  93. ncbi Heteroplasmic conjugates formed by the fusion of starfish oocyte pairs with a 12 minute time difference in the maturation phase
    M Yoneda
    The Tateyama Marine Laboratory, Ochanomizu Univerity, Chiba, Japan
    Dev Growth Differ 42:121-8. 2000
    ..Under polarization microscopy two meiotic spindles emerged with a time difference of 10-11 min, which is close to the time difference ..
  94. ncbi Vascular endothelial growth factor induces extracellular matrix proteins and osteopontin in the umbilical artery
    Manfred Infanger
    Department of Trauma and Reconstructive Surgery, Charite Universitatsmedizin, Berlin, Germany
    Ann Vasc Surg 22:273-84. 2008
    ..Afterward, the vessels were analyzed applying morphometry, sirius red staining, polarization microscopy, Western blot analysis, and immunohistochemistry...
  95. ncbi Foreign material as a cause of choledocholithiasis
    V Prochazka
    2nd Internal Clinic, Palacky University, Olomouc, Czech Republic
    Endoscopy 31:383-5. 1999
    ..Gallstones obtained endoscopically from the biliary duct were analyzed to determine their structure and the presence of foreign material. The possible correlation between foreign material in gallstones and clinical data was investigated...
  96. ncbi Effect of low level laser therapy (830 nm) with different therapy regimes on the process of tissue repair in partial lesion calcaneous tendon
    Flávia Schlittler Oliveira
    Department of Plastic Surgery, Sao Paulo Federal University UNIFESP, Sao Paulo, SP 04024 900, Brazil
    Lasers Surg Med 41:271-6. 2009
    ..To assess the effect of low intensity laser therapy on the process of tissue repair in calcaneous tendon after undergoing a partial lesion...
  97. ncbi Dissolution improvement and the mechanism of the improvement from cocrystallization of poorly water-soluble compounds
    Koji Shiraki
    Discovery Platform Technology Department, Chugai Pharmaceutical Co Ltd, 1 135 Komakado, Gotemba, Shizuoka 412 8513, Japan
    Pharm Res 25:2581-92. 2008
    ..To demonstrate improvement in the dissolution of exemestane and megestrol acetate from cocrystallization using various particle sizes and to investigate the mechanism of the improved dissolution...
  98. ncbi Polarimetric analysis of the human cornea measured by polarization-sensitive optical coherence tomography
    Felix Fanjul-Velez
    University of Cantabria, Electronics Technology, Systems and Automation Engineering Department, Applied Optical Techniques Group, Avenida de los Castros s n, Santander, Cantabria 39005 Spain
    J Biomed Opt 15:056004. 2010
    ..like polarization-sensitive optical coherence tomography (PS-OCT), scanning laser polarimetry, or polarization microscopy are contradictory...
  99. pmc Laser-induced collagen remodeling and deposition within the basilar membrane of the mouse cochlea
    Gentiana I Wenzel
    Baylor College of Medicine, Bobby R Alford Department of Otolaryngology, Head and Neck Surgery, One Baylor Plaza, NA102, Houston, Texas 77030, USA
    J Biomed Opt 12:021007. 2007
    ..The mice were sacrificed 14 to 16 days later and collagen organization was studied. Polarization microscopy revealed that laser irradiation increased the birefringence within the basilar membrane in a dose-..
  100. ncbi Primary tooth ankylosis: report of case with histological analysis
    G Mancini
    Department of Human Anatomy and Histology, University of Florence, Italy
    ASDC J Dent Child 62:215-9. 1995
    ..and radiographic signs of ankylosis, were subject to histological examination by bright field and polarization microscopy. The roots revealed signs of ongoing resorptive and reparative processes and in some areas dentin with ..
  101. ncbi Amyloid in surgical pathology
    Christoph Rocken
    Department of Pathology, Otto von Guericke University, Leipziger Strasse 44, 39120, Magdeburg, Germany
    Virchows Arch 443:3-16. 2003
    ..Histological proof can be obtained using Congo-red staining and polarization microscopy. However, small deposits may be difficult to discern, and sensitivity can be improved using fluorescence ..

Research Grants52

  1. Orientation independent DIC and polarization microscopy
    Michael Shribak; Fiscal Year: 2011
    ....
  2. Orientation independent DIC and polarization microscopy
    Michael Shribak; Fiscal Year: 2013
    ..The polychromatic polscope will be able to provide sharp images of fast moving birefringent organelles, rapid birefringence propagation caused be nerve impulses, etc. ..
  3. Improved Automated Urinalysis
    Fatima Merchant; Fiscal Year: 2007
    ..Our approach is to use polarization microscopy to obtain new features to aid classification of crystals, casts and other particles...
  4. STRUCTURAL BASIS OF KINESIN MOTOR MOVEMENT
    Hernando Sosa; Fiscal Year: 2006
    ..be characterized at different points in the ATPase cycle using cryo- electron microscopy and fluorescence polarization microscopy on kinesin molecules fluorescently labeled on the motor domain...
  5. Quantitative Optical Phase, Amplitude, and Polarization Microscopy
    Remy Tumbar; Fiscal Year: 2010
    ....
  6. Polarization microscopy for three-dimensional imaging of biological microstructur
    Mircea Mujat; Fiscal Year: 2009
    ..A novel technique for imaging biological tissue without labeling or staining, called Mueller matrix polarization microscopy, is introduced for visualizing the distribution of the anisotropic complex refractive index, an intrinsic ..
  7. STRUCTURE, FUNCTION & MECHANISM OF CONTRACTILE PROTEINS
    YALE GOLDMAN; Fiscal Year: 2002
    ..motions of both single molecules and ordered arrays of contractile proteins, time-resolved fluorescence polarization microscopy, and ultra-rapid freezing electron microscopy synchronized to transient molecular events...
  8. COLLAGEN AND THE HYPERTROPHIED HEART
    KARL WEBER; Fiscal Year: 1993
    ..Picrosirius red and polarization microscopy will be used to identify the different patterns of FIB and the structural nature and composition of ..
  9. Mechanics and Mechanisms of HIV Reverse Transcriptase
    David Keller; Fiscal Year: 2003
    ..and carry out single-molecule kinetics measurements on individual REV RT molecules using fluorescence polarization microscopy. 4...
  10. Nanoscale Organization of the OHC Lateral Wall
    JENNIFER GREESON; Fiscal Year: 2007
    ..the behavior of membrane molecules under perturbation using an optical technique called fluorescence polarization microscopy (FPM)...
  11. PHYSICAL STRUCTURE OF VIRUSES, CHROMOSOMES & CELL NUCLEI
    MARCOS MAESTRE; Fiscal Year: 1993
    ..dichroism (CD) and flow oriented CD; b) circular dichroic microspectrophotometer; c) differential imaging polarization microscopy; d) fluorescence detected circular dichroism (FDCD); and e) scattered corrected CD by fluorscat and FDCD ..
  12. Quantitative molecular imaging in articular cartilage
    Yang Xia; Fiscal Year: 2009
    ....
  13. Towards In Situ Optical Pathology of Nonmelanoma Skin Cancers
    Anna Yaroslavsky; Fiscal Year: 2008
    ..The diagnostic application of this technology holds the potential to replace biopsy, thus reducing morbidity and time associated with that invasive procedure. ..
  14. Optical Mapping of Nonmelanoma Skin Cancers
    Anna Yaroslavsky; Fiscal Year: 2005
    ..v) Evaluate the clinical prototype and the developed imaging methods in a surgical practice environment. ..
  15. Probing Cell Division with Synthetic Chemistry
    Timothy Mitchison; Fiscal Year: 2008
    ..Having found small molecule tools that perturb cell division by novel mechanisms, we will test their ability to kill cancer cells in vitro. ..
  16. Laser Acupuncture
    Peter Whittaker; Fiscal Year: 2006
    ..Finally, with an established animal model, it will be possible to address mechanistic questions using pharmacological interventions in an attempt to block the benefits of laser acupuncture treatment. ..
  17. Optical detection of neural activity with phase sensitive interferometry
    BORIS PARK; Fiscal Year: 2008
    ..Park to combine expertise in physics and biomedical optics with neuroscience, substantially adding to his capabilities as an independent researcher. [unreadable] [unreadable] [unreadable] [unreadable]..
  18. IKSI: 2nd International Urolithiasis Research Symposium
    Andrew Evan; Fiscal Year: 2008
    ..This assumption was supported by the great success of the 1st International Urolithiasis Research symposium and the high level of interest in the 2nd symposium date. [unreadable] [unreadable] [unreadable]..
  19. High-Speed Label-Free Optical Detection System for Small-Molecule Microarrays
    Xiangdong Zhu; Fiscal Year: 2009
    ..abstract_text> ..
  20. GAP JUNCTIONAL COMMUNICATIONS IN WOUND HEALING
    H Ehrlich; Fiscal Year: 2009
    ..abstract_text> ..
  21. Dentin Fluoride as a Biomarker for Childhood Fluoride Intake
    JAMES STERN WEFEL; Fiscal Year: 2010
    ....
  22. Cytoskeleton polymerization dynamics in the cell cycle
    Timothy J Mitchison; Fiscal Year: 2010
    ..Understanding midbody assembles will reveal principles for generating asymmetric assemblies in the cytoplasm, and will tell us how the cleavage furrow is positioned. ..
  23. Fourier Domain Functional OCT
    Zhongping Chen; Fiscal Year: 2009
    ....
  24. Validation of New Diagnostic Technologies for Dental Caries
    JAMES STERN WEFEL; Fiscal Year: 2010
    ..The clinical data will be paired with the PLM for validity measurements and analyzed by the biostatisticians. ..
  25. Synovium-based articular cartilage tissue engineering
    Ernst B Hunziker; Fiscal Year: 2010
    ..We believe that this project is highly innovative and that the results of this research will have a significant impact on the future treatment of osteoarthritic lesions and on improvement of the health status of the US population. ..
  26. MUC-1 related cancer immunity: determinants and predictive significance
    Daniel Cramer; Fiscal Year: 2009
    ..The findings of our study could provide the basis for developing a safe cancer- preventing vaccine for ovarian cancer and perhaps other MUC1-expressing tumors. ..
  27. Genes, Hormones & Environment in an Ovarian Cancer Model
    Daniel Cramer; Fiscal Year: 2007
    ..Our continued goal is to identify modifiable risk factors and chemo preventive agents for a common and lethal cancer in women. ..
  28. A Request for support of 25th SPRSM Meeting
    James Wang; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  29. DEVELOPMENT OF AUTOMATED POLARIZED HIGHT MICROSCOPE
    Rudolf Oldenbourg; Fiscal Year: 2001
    ..abstract_text> ..
  30. DEVELOPMENT OF A TREATMENT FOR OSTEOGENESIS IMPERFECTA
    R Martin; Fiscal Year: 2002
    ..abstract_text> ..
  31. EPIDEMIOLOGIC AND BIOLOGIC PREDICTORS OF IVF SUCCESS
    Daniel Cramer; Fiscal Year: 2002
    ....
  32. TEM with Digital and Cryopreparation Systems
    Andrew Evan; Fiscal Year: 2003
    ..Dr. Richard Gregory will employ immunohistochemistry to examine the role of a Streptococcus mutans 65 kDa fimbrial protein binding as a mechanism for the induction of dental carries. ..
  33. 3-D Image Restoration for Polarized Light Microscopy
    Rudolf Oldenbourg; Fiscal Year: 2002
    ..The image restoration procedures will greatly enhance the utility of the P01-Scope for biological and medical applications to non-invasively analyze the architectural dynamics of living cells. ..
  34. HIGH SPEED HIGH RESOLUTION PHASE RESOLVED OCT/ODT
    Zhongping Chen; Fiscal Year: 2001
    ..abstract_text> ..
  35. 3-D Image Restoration for Polarized Light Microscopy
    Rudolf Oldenbourg; Fiscal Year: 2003
    ..The image restoration procedures will greatly enhance the utility of the P01-Scope for biological and medical applications to non-invasively analyze the architectural dynamics of living cells. ..
  36. MATH INTERVENTION FOR CHILDREN WITH LEUKEMIA
    Ida Moore; Fiscal Year: 2004
    ....
  37. ELECTRON MICROSCOPE
    Timothy Mitchison; Fiscal Year: 2004
    ..The automated controls and digital image acquisition will also be optimal for introducing new users to electron microscopy and for minimizing maintenance requirements that might arise from operator inexperience. ..
  38. ACTIN DYNAMICS AND CELL LOCOMOTION
    Timothy Mitchison; Fiscal Year: 2004
    ..For perturbation experiments we will use protein tools, and also cell permeable chemicals coming out of a screening effort at the Harvard Institute of Chemistry and Cell Biology (ICCB). ..
  39. Bringing Molecular Contrast to OCT
    BRIAN APPLEGATE; Fiscal Year: 2005
    ..We intend to couple proven nonlinear spectroscopic techniques to optical coherence tomography, in order to provide molecular contrast. ..
  40. Tissue protein imaging via second harmonic generaton
    Paul Campagnola; Fiscal Year: 2006
    ..iii) Determine ideal optical parameters for SHG imaging of tissues in vivo. ..
  41. MULTIPHOTON BIOMEDICAL NANOFABRICATION
    Paul Campagnola; Fiscal Year: 2001
    ..3) To fabricate dimensionally complex channels and structures for applications to microfluidics. 4) To fabricate composites and biomaterials for tissue engineering. ..
  42. An interdisciplinary and integrative study of tendinopathy
    James H C Wang; Fiscal Year: 2010
    ....
  43. ONLY NEURONS READ NEURAL CODES
    RAYMON GLANTZ; Fiscal Year: 2002
    ..The problem of neural coding has important implications for the design of prosthetic devices and the linkage between such devices and the nervous system. ..
  44. Low-Cost Device for Digital Retinal Imaging
    Ann E Elsner; Fiscal Year: 2010
    ..While this project focuses on diabetic retinopathy in humans, future applications include other retinal disorders in both humans and animal models. ..
  45. Optical Scatter Microscopy
    NADA BOUSTANY; Fiscal Year: 2002
    ..In this initial phase of development, the investigators will use OSM to study mitochondrial dysfunction during cell death. The long-term goal is to develop OSM as a tool for functional microscopy. ..
  46. Collagen Crosslinking Effects on Bone Fragility
    Deepak Vashishth; Fiscal Year: 2009
    ..abstract_text> ..
  47. Low-Cost Device for Digital Retinal Imaging
    ANN ELSNER; Fiscal Year: 2007
    ..We will investigate the key features considered necessary for early detection grading, and also more the serious damage that is typically discovered late in the rural and urban underserved. ..
  48. Risk for New onset of Depression in Perimenopausal Women
    Daniel Cramer; Fiscal Year: 2009
    ..abstract_text> ..
  49. MULTIPHOTON BIOMEDICAL NANOFABRICATION
    Paul Campagnola; Fiscal Year: 2003
    ..3) To fabricate dimensionally complex channels and structures for applications to microfluidics. 4) To fabricate composites and biomaterials for tissue engineering. ..
  50. IKSI: 1st Annual International Urolithiasis Research Symposium
    Andrew Evan; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  51. Optical Biopsy Using MEMs Technology
    Zhongping Chen; Fiscal Year: 2006
    ..Finally, the scanning probe technology developed in this proposal can also be used for endoscopic confocal and two-photon imaging. ..
  52. Risk for Renal Injury Caused by Shock Wave Lithotripsy
    Andrew Evan; Fiscal Year: 2008
    ..All of these proposed studies aim at understanding the adverse effects of shock waves and advancing the safety of all stone patients at a time when reports of adverse effects in SWL are on the rise. ..