methods

Summary

Top Publications

  1. ncbi Measurement of intestinal cholesterol absorption by plasma and fecal dual-isotope ratio, mass balance, and lymph fistula methods in the mouse: an analysis of direct versus indirect methodologies
    David Q H Wang
    Gastroenterology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Lipid Res 44:1042-59. 2003
  2. ncbi Suicide in Blantyre, Malawi (2000-2003)
    Charles P Dzamalala
    College of Medicine, University of Malawi, Private Bag 360, Blantyre 3, Malawi Mwanza District Hospital, Ministry of Health, Post Office Box 80, Mwanza, Malawi
    J Clin Forensic Med 13:65-9. 2006
  3. ncbi Epidemiology of suicide by hanging in Transkei, South Africa
    Bl Meel
    Dip HIV AIDS Management Stellenbosch, Faculty of Medicine and Health Sciences, University of Transkei, Umtata, South Africa
    Am J Forensic Med Pathol 27:75-8. 2006
  4. ncbi Toxicologic findings in suicide: a 10-year retrospective review of Kentucky medical examiner cases
    Lisa B E Shields
    Office of the Chief Medical Examiner, Louisville, Kentucky, USA
    Am J Forensic Med Pathol 27:106-12. 2006
  5. pmc Methods for the thematic synthesis of qualitative research in systematic reviews
    James Thomas
    EPPI Centre, Social Science Research Unit, Institute of Education, University of London, UK
    BMC Med Res Methodol 8:45. 2008
  6. ncbi The tandem affinity purification (TAP) method: a general procedure of protein complex purification
    O Puig
    European Molecular Biology Laboratory Meyerhofstrasse 1, Heidelberg, D-69117, Germany
    Methods 24:218-29. 2001
  7. ncbi Methods for exploring heterogeneity in meta-analysis
    F Song
    University of Birmingham
    Eval Health Prof 24:126-51. 2001
  8. pmc Comparative methods for association studies: a case study on metabolite variation in a Brassica rapa core collection
    Dunia Pino Del Carpio
    Laboratory of Plant Breeding, Wageningen University, Wageningen, The Netherlands
    PLoS ONE 6:e19624. 2011
  9. ncbi Methods of assessment of selenium status in humans: a systematic review
    Kate Ashton
    School of Medicine, Health Policy and Practice, The University of East Anglia, Norwich, United Kingdom
    Am J Clin Nutr 89:2025S-2039S. 2009
  10. pmc A comprehensive assessment of methods for de-novo reverse-engineering of genome-scale regulatory networks
    Varun Narendra
    Center for Health Informatics and Bioinformatics, New York University School of Medicine, New York, NY 10016, USA
    Genomics 97:7-18. 2011

Research Grants

  1. THE AGRICULTURAL HEALTH STUDY - FIELD STATIONS
    Charles Lynch; Fiscal Year: 2010
  2. NIEHS SUPPORT OF THE AHS COHORT STUDY AT NCI
    Charles Knott; Fiscal Year: 2010
  3. ED Disability Diagnostic Tool: An HIT Feasibility Study
    Lori Ann Post; Fiscal Year: 2013
  4. National Study of Disability Trends and Dynamics
    Judith Kasper; Fiscal Year: 2013
  5. EPIDEMIOLOGY OF ALCOHOL PROBLEMS
    Thomas K Greenfield; Fiscal Year: 2013
  6. A Novel Bayesian Model Averaging Approach for Genome Wide Association Studies
    Michael D Swartz; Fiscal Year: 2010
  7. ELDER PAIN--ASSESSMENT OF INTENSITY
    Keela Herr; Fiscal Year: 1999
  8. Comparative Effectiveness of Alcohol Treatments
    Georgiy Bobashev; Fiscal Year: 2011
  9. PERIODONTITIS AND SYSTEMIC DISEASE: CONFOUNDING?
    Philippe Hujoel; Fiscal Year: 2001
  10. Strategies for the Syntheses of Bioactive Targets
    Stephen Martin; Fiscal Year: 2010

Detail Information

Publications264 found, 100 shown here

  1. ncbi Measurement of intestinal cholesterol absorption by plasma and fecal dual-isotope ratio, mass balance, and lymph fistula methods in the mouse: an analysis of direct versus indirect methodologies
    David Q H Wang
    Gastroenterology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Lipid Res 44:1042-59. 2003
    ..In the present study, we adapted four standard methods, one direct (lymph collection) and three indirect (plasma and fecal dual-isotope ratio, and sterol balance) ..
  2. ncbi Suicide in Blantyre, Malawi (2000-2003)
    Charles P Dzamalala
    College of Medicine, University of Malawi, Private Bag 360, Blantyre 3, Malawi Mwanza District Hospital, Ministry of Health, Post Office Box 80, Mwanza, Malawi
    J Clin Forensic Med 13:65-9. 2006
    ..This audit highlights a need for investigations into the sale and use of agricultural pesticides. A prospective study of social and demographic factors around suicide should be undertaken to target groups at highest risk...
  3. ncbi Epidemiology of suicide by hanging in Transkei, South Africa
    Bl Meel
    Dip HIV AIDS Management Stellenbosch, Faculty of Medicine and Health Sciences, University of Transkei, Umtata, South Africa
    Am J Forensic Med Pathol 27:75-8. 2006
    ..4:1. The 2 youngest suicide victims were also males aged 9 years. Peak of these hangings is in May and November and least in September. There is increasing trend of hanging especially among young adults between 20 and 29 years old...
  4. ncbi Toxicologic findings in suicide: a 10-year retrospective review of Kentucky medical examiner cases
    Lisa B E Shields
    Office of the Chief Medical Examiner, Louisville, Kentucky, USA
    Am J Forensic Med Pathol 27:106-12. 2006
    ..4%, 37.4%, and 29.2% of the subjects, respectively. The collection of these data serves the goals of public health and clinicians in devising strategies for suicide prevention...
  5. pmc Methods for the thematic synthesis of qualitative research in systematic reviews
    James Thomas
    EPPI Centre, Social Science Research Unit, Institute of Education, University of London, UK
    BMC Med Res Methodol 8:45. 2008
    ..In response to this, methods for undertaking these syntheses are currently being developed...
  6. ncbi The tandem affinity purification (TAP) method: a general procedure of protein complex purification
    O Puig
    European Molecular Biology Laboratory Meyerhofstrasse 1, Heidelberg, D-69117, Germany
    Methods 24:218-29. 2001
    Identification of components present in biological complexes requires their purification to near homogeneity. Methods of purification vary from protein to protein, making it impossible to design a general purification strategy valid for ..
  7. ncbi Methods for exploring heterogeneity in meta-analysis
    F Song
    University of Birmingham
    Eval Health Prof 24:126-51. 2001
    ..This article reviews methods used in meta-analysis for exploring heterogeneity, including statistical tests for homogeneity, methods for ..
  8. pmc Comparative methods for association studies: a case study on metabolite variation in a Brassica rapa core collection
    Dunia Pino Del Carpio
    Laboratory of Plant Breeding, Wageningen University, Wageningen, The Netherlands
    PLoS ONE 6:e19624. 2011
    ..The rapid availability of large datasets makes it necessary to explore statistical methods that can be computationally less intensive and more flexible for data exploration.
  9. ncbi Methods of assessment of selenium status in humans: a systematic review
    Kate Ashton
    School of Medicine, Health Policy and Practice, The University of East Anglia, Norwich, United Kingdom
    Am J Clin Nutr 89:2025S-2039S. 2009
    ..To understand the effect of selenium intake on health, it is important to identify sensitive and population-specific biomarkers of selenium status...
  10. pmc A comprehensive assessment of methods for de-novo reverse-engineering of genome-scale regulatory networks
    Varun Narendra
    Center for Health Informatics and Bioinformatics, New York University School of Medicine, New York, NY 10016, USA
    Genomics 97:7-18. 2011
    ..While many methods have been recently developed for this task, their absolute and relative performance remains poorly understood...
  11. ncbi Global DNA methylation: comparison of enzymatic- and non-enzymatic-based methods
    Monica S Rocha
    Metabolism and Genetics Group Met and Gen Group, Institute for Medicines and Pharmaceutical Sciences iMed UL, Faculty of Pharmacy, University of Lisbon, Portugal
    Clin Chem Lab Med 48:1793-8. 2010
    The most frequently used methods for measuring global DNA methylation are based on two different principles: the use of methylation-sensitive restriction endonucleases followed by analysis of the obtained fragments, or the hydrolysis of ..
  12. ncbi Evaluation of different methods detecting intracellular generation of free radicals
    Jiri Wilhelm
    Department of Medical Chemistry and Biochemistry, Centre of Cardiovascular Research, Charles University, Prague, Czech Republic
    Mol Cell Biochem 328:167-76. 2009
    ..Superoxide production was confirmed by a specific histochemical method using Mn(2+). All methods demonstrated higher production of ROS in older cells...
  13. ncbi Oxidative degradations of reactive blue 4 dye by different advanced oxidation methods
    Belgin Gözmen
    Department of Chemistry, Arts and Sciences Faculty, Mersin University, Mersin, Turkey
    J Hazard Mater 168:129-36. 2009
    ..The most efficient method for mineralization of RB4 was WPO, but in all methods TOC removal efficiency was above 75% after 60 min of treatment.
  14. pmc Characterization of global yeast quantitative proteome data generated from the wild-type and glucose repression saccharomyces cerevisiae strains: the comparison of two quantitative methods
    Renata Usaite
    BioCentrum DTU, Technical University of Denmark, Kgs Lyngby, Denmark
    J Proteome Res 7:266-75. 2008
    ..The functional categorization of the relative protein expression differences that occur in Snf1-deficient strains uncovers a wide range of biological processes regulated by this important cellular kinase...
  15. pmc Methods for equivalence and noninferiority testing
    Gisela Tunes da Silva
    Department of Statistics, University of Sao Paulo, Sao Paulo, SP, Brazil
    Biol Blood Marrow Transplant 15:120-7. 2009
    ..The methods are illustrated on 2 recent studies in hematopoietic cell transplantation.
  16. ncbi Using population-based cancer registry data to assess the burden of human papillomavirus-associated cancers in the United States: overview of methods
    Meg Watson
    Division of Cancer Prevention and Control, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Cancer 113:2841-54. 2008
    ..This article describes methods used to assess the burden of HPV-associated cervical, vulvar, vaginal, penile, anal, and oral cavity/..
  17. ncbi The development of clinical practice guidelines and guidance statements of the American College of Physicians: summary of methods
    Amir Qaseem
    American College of Physicians, Philadelphia, Pennsylvania 19106, USA
    Ann Intern Med 153:194-9. 2010
    ..All ACP clinical practice guidelines and clinical guidance statements, if not updated, are considered automatically withdrawn or invalid 5 years after publication or once an update has been issued...
  18. pmc Identifying drugs that cause acute thrombocytopenia: an analysis using 3 distinct methods
    Jessica A Reese
    Department of Biostatistics and Epidemiology, College of Public Health, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
    Blood 116:2127-33. 2010
    ..To provide a resource for diagnosis of DITP and for drug safety surveillance, we analyzed 3 distinct methods for identifying drugs that may cause thrombocytopenia...
  19. ncbi Comparison of platelet aggregability and P-selectin surface expression on platelets isolated by different methods
    B Walkowiak
    Department of Biophysics, Medical University of Lodz, Poland
    Thromb Res 99:495-502. 2000
    Three methods commonly used for isolation of blood platelets from plasma were compared. Platelets were isolated by: 1) a washing method; 2) a method of metrizamide-gradient centrifugation; 3) a modified method of gel-filtration...
  20. ncbi Comparison of three methods for isolation of urinary microvesicles to identify biomarkers of nephrotic syndrome
    Ilse M Rood
    Department of Nephrology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Kidney Int 78:810-6. 2010
    ..or nanomembrane ultrafiltration from normal urine; however, little is known about the efficiency of these methods in isolating microvesicles from patients with nephrotic-range proteinuria...
  21. ncbi Methods of assessment of zinc status in humans: a systematic review
    Nicola M Lowe
    Centre for Applied Sport and Exercise Sciences, School of Psychology, The University of Central Lancashire, Preston, United Kingdom
    Am J Clin Nutr 89:2040S-2051S. 2009
    ..The search for a reliable, sensitive, and specific index of zinc status has been the subject of considerable research, which has resulted in the identification of a number of potentially useful biomarkers...
  22. ncbi Pretreatment methods to improve sludge anaerobic degradability: a review
    H Carrère
    INRA, UR50, Laboratoire de Biotechnologie de l Environnement, Avenue des Etangs, F 11100 Narbonne, France
    J Hazard Mater 183:1-15. 2010
    ..Mechanical treatment methods are comparable, and provide moderate performance improvements with moderate electrical input...
  23. ncbi Comparison of neutron activated and radiolabeled microsphere methods for measurement of transmural myocardial blood flow in dogs
    John G Kingma
    Institut Universitaire de Cardiologie et Pneumologie, Department of Medicine, Laval University, Quebec City, Quebec, G1K 7P4
    J Thromb Thrombolysis 19:201-8. 2005
    ..A new method using neutron activated microspheres (NAM) has recently been described...
  24. ncbi Comparison of three methods for estimating the standard error of the area under the curve in ROC analysis of quantitative data
    Karim O Hajian-Tilaki
    Acad Radiol 9:1278-85. 2002
    Several methods have been proposed for estimating the standard error (SE) of the area under the curve (AUC) in receiver operating characteristic analysis...
  25. ncbi Simultaneous elimination of dissolved and dispersed pollutants from cutting oil wastes using two aqueous phase extraction methods
    Z Talbi
    U S T Oran, Faculty of Sciences, Department of Chemistry, BP 1505, Elmnaouar, 31000 Oran, Algeria
    J Hazard Mater 163:748-55. 2009
    Oily wastewater experimental study has been accomplished using two aqueous phases extraction methods on the basis of phase separation properties of non-ionic surfactants above the so-called cloud point curve and the solubilization ..
  26. ncbi Treatment methods for the remediation of nitroaromatic explosives
    J D Rodgers
    School of Engineering, University of Guelph, Ontario, Canada
    Water Res 35:2101-11. 2001
    ..This paper reviews technologies that are available or under investigation to remediate areas contaminated with these compounds...
  27. pmc Overcoming the false-minima problem in direct methods: structure determination of the packaging enzyme P4 from bacteriophage phi13
    Christoph Meier
    Division of Structural Biology, The Henry Wellcome Building for Genomic Medicine, Oxford University, Roosevelt Drive, Oxford OX3 7BN, England
    Acta Crystallogr D Biol Crystallogr 61:1238-44. 2005
    ..Here, it is demonstrated how the difficulties in finding a correct phase solution arise from an intricate false-minima problem...
  28. ncbi Water transport across mammalian cell membranes
    A S Verkman
    Department of Medicine, University of California, San Francisco 94143, USA
    Am J Physiol 270:C12-30. 1996
    ..Further work should be directed at elucidation of the role of water channels in normal physiology and disease, molecular analysis of regulatory mechanisms, and water channel structure determination at atomic resolution...
  29. ncbi Measurement of converting enzyme activity by antibody-trapping of generated angiotensin II. Comparison with two other methods
    J Nussberger
    Division of Hypertension, University Hospital, Lausanne, Switzerland
    Am J Hypertens 5:393-8. 1992
    ..5 to 24 h after oral administration of 20 mg enalapril. The percentage of ACE inhibition indicated by both methods was almost identical (r = 0.93, n = 60, P less than .001)...
  30. ncbi Methods of assessment of iodine status in humans: a systematic review
    Danijela Ristić-Medić
    Institute for Medical Research, the Laboratory for Nutrition and Metabolism, The University of Belgrade, Belgrade, Serbia
    Am J Clin Nutr 89:2052S-2069S. 2009
    ..Biomarkers of iodine status are required to study iodine deficiency disorders in different parts of the world and to evaluate the effects of fortification strategies...
  31. ncbi Methods of assessment of n-3 long-chain polyunsaturated fatty acid status in humans: a systematic review
    Katalin Fekete
    Department of Pediatrics, University of Pecs, Pecs, Hungary
    Am J Clin Nutr 89:2070S-2084S. 2009
    ..The availability of reliable biomarkers of n-3 (omega-3) long-chain polyunsaturated fatty acid (LCPUFA) status is a prerequisite for linking dietary n-3 LCPUFA status to clinical outcomes...
  32. ncbi Critical bioethics: beyond the social science critique of applied ethics
    Adam M Hedgecoe
    Department of Sociology, School of Social Sciences, University of Sussex, Falmer, Brighton BN1 9QN, UK
    Bioethics 18:120-143. 2004
    ..The aim is to produce a rigorous normative analysis of lived moral experience...
  33. pmc Comparison of alternative weight recalibration methods for diagnosis-related groups
    J R Rogowski
    RAND Corporation, Washington, DC 20037
    Health Care Financ Rev 12:87-101. 1990
    ..At the provider level, charge weights result in higher payments to large urban hospitals and teaching hospitals, relative to cost weights...
  34. ncbi Evaluation of four rapid methods for hemoglobin screening of whole blood donors in mobile collection settings
    Antonia Gómez Simón
    Centro Regional de Hemodonacion, C Ronda de Garay s n, Unit of Hematology and Clinical Oncology, University of Murcia, 30003 Murcia, Spain
    Transfus Apher Sci 36:235-42. 2007
    ..Predonation hemoglobin measurement is a problematic requirement in mobile donation settings, where accurate determination of venous hemoglobin by hematology analyzers is not available...
  35. pmc Comparison of marine spatial planning methods in Madagascar demonstrates value of alternative approaches
    Thomas F Allnutt
    Department of Environmental Science, Policy and Management, University of California, Berkeley, Berkeley, California, United States of America
    PLoS ONE 7:e28969. 2012
    ..To assist this process, we compare four methods for marine spatial planning of Madagascar's west coast...
  36. ncbi Comparison of fixation disparities obtained by objective and subjective methods
    N Fogt
    Ohio State University College of Optometry, Columbus, USA
    Vision Res 38:411-21. 1998
    ..The remaining subjects who lacked this effect had "flat" FD curves indicative of high vergence adaptation...
  37. ncbi Comparison of different methods to assess body composition of weight loss in obese and diabetic patients
    P Ritz
    INSERM UMR 694, Angers, France
    Diabetes Res Clin Pract 77:405-11. 2007
    ..No effect of diabetes per se was observed. A 3- or 4-compartmental analysis is necessary to accurately estimate body composition and its changes during weight loss...
  38. ncbi Time-resolved biophysical methods in the study of protein folding
    K W Plaxco
    New Chemistry Laboratory, University of Oxford, UK
    Curr Opin Struct Biol 6:630-6. 1996
    ..Recent advances in these techniques, the use of novel methods of initiating refolding, and a convergence of theoretical and experimental approaches are leading to a detailed ..
  39. ncbi In vitro methods for measuring the dry matter digestibility of ruminant feedstuffs: comparison of methods and inoculum source
    S J Mabjeesh
    Department of Animal Sciences, The Faculty of Agricultural, Food, and Environmental Quality Sciences, Rehovot, Israel
    J Dairy Sci 83:2289-94. 2000
    ..The traditional method buffer was used for both methods. We also compared two sources of rumen inoculum from sheep and dairy cows...
  40. ncbi Assessing potential biomarkers of micronutrient status by using a systematic review methodology: methods
    Lee Hooper
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, United Kingdom
    Am J Clin Nutr 89:1953S-1959S. 2009
    ..To explore the relation between micronutrient status and health, it is important to understand which markers of micronutrient status can be relied on and under what circumstances...
  41. ncbi Comparison of methods for calculating serum osmolality: multivariate linear regression analysis
    Mehdi Rasouli
    Department of Clinical Biochemistry, Faculty of Medicine, Medical Sciences University of Mazandaran, Sari, Iran
    Clin Chem Lab Med 43:635-40. 2005
    There are several methods for calculating serum osmolality, and their accordance with measured osmolality is the subject of controversy.
  42. ncbi Unplanned versus planned suicide attempters, precipitants, methods, and an association with mental disorders in a Korea-based community sample
    Hong Jin Jeon
    Department of Psychiatry, Depression Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
    J Affect Disord 127:274-80. 2010
    Studies have consistently reported that a considerable proportion of suicidal attempts are unplanned. We have performed the first direct comparison between planned and unplanned attempts including associated methods and precipitants.
  43. pmc Competitive adsorption of thiolated polyethylene glycol and mercaptopropionic acid on gold nanoparticles measured by physical characterization methods
    De Hao Tsai
    Ceramics Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, USA
    Langmuir 26:10325-33. 2010
    ..The desorption rate constant of SH-PEG from the Au-NP surface by MPA displacement was strongly affected by the concentration of MPA and the excess SH-PEG in solution...
  44. pmc Comparison of two methods for calculating the frictional properties of articular cartilage using a simple pendulum and intact mouse knee joints
    Elizabeth I Drewniak
    Department of Orthopaedics, Bioengineering Laboratory, The Warren Alpert Medical School of Brown University RIH, Providence, RI, USA
    J Biomech 42:1996-9. 2009
    ..In this study, we examined two analysis methods for calculating the coefficient of friction (micro) using a simple pendulum system and BL6 murine knee joints (n=..
  45. ncbi Study on the toxic effects of diphenol compounds on soil microbial activity by a combination of methods
    Huilun Chen
    Key Laboratory of Biogeology and Environmental Geology Laboratory of Chinese Ministry of Education, School of Environmental Studies, Sino Hungarian Joint Laboratory of Environmental Science and Health, China University of Geosciences, No 388 Lu Mo Road, Wuhan, PR China
    J Hazard Mater 167:846-51. 2009
    ..The combination of the three methods is a more comprehensive toxicological investigation of a complex microbiological system...
  46. ncbi Evaluation of two methods for concentrating perrhenate (188 Re) eluates obtained from 188 W-188 Re generator
    Sishir Kumar Sarkar
    Board of Radiation and Isotope Technology BRIT, BARC Vashi Complex, Navi Mumbai 400 705, India
    Appl Radiat Isot 67:234-9. 2009
    Two novel and simple methods for post-elution concentration (PEC) of (188)Re-perrhenate, using (i) a single diethyl amino ethyl (DEAE) cellulose anion exchanger column and (ii) a combination of Dowex-1 x 8 and AgCl columns, are described ..
  47. ncbi The ten-year trend in suicide methods. Evidence from an Asian population
    Kuo Hsuan Chung
    Taipei Medical University Hospital, Department of Psychiatry, Taipei, Taiwan
    Can J Public Health 99:406-10. 2008
    Despite the wealth of studies investigating methods of committing suicide, very few studies have been undertaken in which the focus has been placed on the long-term trend in suicide methods...
  48. ncbi MOD-score analysis with simple pedigrees: an overview of likelihood-based linkage methods
    Konstantin Strauch
    Institute of Medical Biometry and Epidemiology, Philipps University Marburg, Marburg, Germany
    Hum Hered 64:192-202. 2007
    ....
  49. ncbi Calculation of lipophilicity for Pt(II) complexes: experimental comparison of several methods
    Igor V Tetko
    Helmholtz Zentrum Munchen German Research Center for Environmental Health GmbH, Institute of Bioinformatics and Systems Biology, Ingolstadter Landstrasse 1, 85764 Neuherberg, Germany
    J Inorg Biochem 102:1424-37. 2008
    ..is to a large extent determined by their lipophilicity, thus there is a strong interest to develop computational methods to predict this important property...
  50. ncbi Different preparation methods to obtain platelet components as a source of growth factors for local application
    R Zimmermann
    Department of Transfusion Medicine, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Transfusion 41:1217-24. 2001
    ..Various preparation methods were investigated to define standardized blood bank components and to collect data on the growth factor content ..
  51. pmc A benchmark of parametric methods for horizontal transfers detection
    Jennifer Becq
    Dynamique des Structures et Interactions des Macromolécules Biologiques, Institut National de la Santé et de la Recherche Médicale UMR S 665, Universite Paris Diderot, Institut National de la Transfusion Sanguine, Paris, France
    PLoS ONE 5:e9989. 2010
    ..As a consequence numerous parametric methods, using only the information embedded in the genomes, have been designed to detect HGTs...
  52. pmc Comparison of population-based association study methods correcting for population stratification
    Feng Zhang
    Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an, Shaanxi, China
    PLoS ONE 3:e3392. 2008
    ..Several statistical methods have been proposed to reduce the impact of population stratification on population-based association studies...
  53. pmc Method for determining molar concentrations of metabolites in complex solutions from two-dimensional 1H-13C NMR spectra
    Ian A Lewis
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, Wisconsin 53706, USA
    Anal Chem 79:9385-90. 2007
    ..2% technical error under nearly ideal conditions. We propose FMQ by NMR as a practical alternative to 1D (1)H NMR for metabolomics studies in which 50-mg (extract dry weight) samples can be obtained...
  54. ncbi Are seasonalities in suicide dependent on suicide methods? A reappraisal
    Vladeta Ajdacic-Gross
    Institute of Social and Preventive Medicine, University of Zurich, Sumatrastr 30, CH 8006 Zurich, Switzerland
    Soc Sci Med 57:1173-81. 2003
    ..ubiquitous phenomenon; however, recent studies have indicated that it is related particularly to violent suicide methods. We investigated differences in suicide seasonalities by suicide methods using Swiss mortality data...
  55. ncbi Different molecular methods for the identification of rarely isolated non-tuberculous mycobacteria and description of new hsp65 restriction fragment length polymorphism patterns
    Bernhard Häfner
    Department of Hygiene and Medical Microbiology, Hygiene Institute, University of Heidelberg, Im Neuenheimer Feld 324, D 69120 Heidelberg, Germany
    Mol Cell Probes 18:59-65. 2004
    ..Identification results obtained by applying different methods yielded conflicting results...
  56. ncbi Methods of choice in completed suicides: gender differences and review of literature
    Tanuj Kanchan
    Department of Forensic Medicine and Toxicology, Kasturba Medical College, Mangalore 575001, India
    J Forensic Sci 54:938-42. 2009
    ..A 4-year retrospective study from January 2000 to December 2003 was conducted to identify the favored methods in realized suicides among males and females in the west coastal region of India...
  57. ncbi A survey of formal methods for determining the centre of rotation of ball joints
    Rainald M Ehrig
    Research Laboratory, Center for Musculoskeletal Surgery, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
    J Biomech 39:2798-809. 2006
    ..For the first time in this survey of formal methods, we classify, analyse and compare different methods (geometric, algebraic, bias compensated algebraic, and Pratt ..
  58. ncbi A comparison of four methods of obtaining a negative impression of the foot
    Carrie Laughton
    Shriners Hospital, Philadelphia, PA, USA
    J Am Podiatr Med Assoc 92:261-8. 2002
    Four methods are currently available for taking a negative impression of the foot for the purpose of fabricating an orthotic device: nonweightbearing plaster casting, partial-weightbearing foam impressions, and partial-weightbearing and ..
  59. ncbi Methods for measuring proteasome activity: current limitations and future developments
    A Liggett
    Centre for Cancer Research and Cell Biology, Queen s University, Belfast, Belfast, UK
    Leuk Res 34:1403-9. 2010
    ..A wide range of methods have been developed to profile proteasome activity...
  60. pmc Comparison of classifier fusion methods for predicting response to anti HIV-1 therapy
    Andre Altmann
    Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, Saarbrucken, Germany
    PLoS ONE 3:e3470. 2008
    ..In this work we compare different classifier fusion methods for combining the individual classifiers.
  61. ncbi Alternative methods of extracting telomerase activity from human tumor samples
    L S Gollahon
    Department of Biological Sciences P O Box 43131, Texas Tech University and the Southwest Cancer Center, Texas Tech University Health Sciences Center, Lubbock, TX 79409 3131, USA
    Cancer Lett 159:141-9. 2000
    ..Our results provide alternative methods for telomerase extraction from solid tumors and small samples that are more convenient and accurate.
  62. ncbi Development of efficient protein extraction methods for shotgun proteome analysis of formalin-fixed tissues
    Xiaogang Jiang
    National Chromatographic R and A Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
    J Proteome Res 6:1038-47. 2007
    ..Valuable proteome information could be obtained by shotgun proteome analysis of formalin-fixed tissue, which presents a new approach for disease biomarker discovery...
  63. ncbi Health-related quality of life: methods of assessment
    I Barofsky
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    Horm Res 56:51-4. 2001
    ..The added value of doing an HRQOL assessment is also discussed...
  64. ncbi Comment on experimental methods and conclusions of impedance spectroscopy of solutions at physiological glucose concentrations by A. Tura, S. Sbrignadello, S. Barison, S. Conti, G. Pacini
    A Caduff
    Solianis Monitoring AG, 8050 Zurich, Switzerland
    Biophys Chem 132:165-6; discussion 167-8. 2008
  65. ncbi A generic protein purification method for protein complex characterization and proteome exploration
    G Rigaut
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Nat Biotechnol 17:1030-2. 1999
    ..Combined with mass spectrometry, the TAP strategy allows for the identification of proteins interacting with a given target protein. The TAP method has been tested in yeast but should be applicable to other cells or organisms...
  66. ncbi Methods: DNA methylation
    Osman El-Maarri
    Institute of experimental heamatology and transfusion medecine, Sigmund Freud strs 25, 53127 Bonn
    Adv Exp Med Biol 544:197-204. 2003
  67. ncbi Optimized protein extraction methods for proteomic analysis of Rhizoctonia solani
    Dilip K Lakshman
    Floral and Nursery Plants Research Unit, USDA ARS, 10300 Baltimore Avenue, Beltsville, Maryland 20705, USA
    Mycologia 100:867-75. 2008
    ..These results testify to the suitability of the two optimized protein extraction protocols for 2-D proteomic studies of R. solani...
  68. ncbi Physical methods of torture and their sequelae: a Sri Lankan perspective
    Priyanjith Perera
    University of Kelaniya, Department of Forensic Medicine, Faculty of Medicine, Thalagolla Road, Ragama, Sri Lanka
    J Forensic Leg Med 14:146-50. 2007
    b>Methods of torture vary from country to country and sometimes within regions in the same country. Knowing torture methods used in a country or region assists in evaluating injuries, scars and other chronic sequelae of torture...
  69. ncbi Evaluation of three methods to rate impairment in patients with complex regional pain syndrome I of one upper extremity
    H M Oerlemans
    Allied Health Services, University Medical Center Nijmegen, The Netherlands
    Clin Rehabil 14:331-9. 2000
    ..To gain insight into the best way of obtaining an impairment rating in complex regional pain syndrome I (CRPS I) of the upper extremity. This syndrome can potentially result in permanent impairment...
  70. pmc A simulation study of three methods for detecting disease clusters
    Geir Aamodt
    Akershus University Hospital, University of Oslo, Norway
    Int J Health Geogr 5:15. 2006
    ..In this article we study three methods suitable for detecting local spatial clusters: (1) a spatial scan statistic (SaTScan), (2) generalized additive ..
  71. ncbi A comparison of methods to detect recombination hotspots
    William Tapper
    Human Genetics Division, School of Medicine, Southampton General Hospital, University of Southampton, Southampton, UK
    Hum Hered 66:157-69. 2008
    A number of linkage disequilibrium (LD)-based methods have been developed to describe recombination and infer hotspots...
  72. pmc The SeqFEATURE library of 3D functional site models: comparison to existing methods and applications to protein function annotation
    Shirley Wu
    Program in Biomedical Informatics, Stanford University, Stanford, CA, 94305 USA
    Genome Biol 9:R8. 2008
    ..We built a library of models that shows good performance compared to other methods. In particular, SeqFEATURE demonstrates significant improvement over other methods when sequence and structural ..
  73. ncbi Multicenter study of homocysteine measurement--performance characteristics of different methods, influence of standards on interlaboratory agreement of results
    A Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, University and IRCCS Maggiore Hospital, Milano, Italy
    Thromb Haemost 85:291-5. 2001
    ..This prompted us to organize a collaborative study to investigate the performance of methods used in this setting and to assess the between-lab comparability of results...
  74. ncbi Evaluation of protein depletion methods for the analysis of total-, phospho- and glycoproteins in lumbar cerebrospinal fluid
    Yuko Ogata
    Mayo Proteomics Research Center and Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Proteome Res 4:837-45. 2005
    ..Two protein removal methods were evaluated: batch mode with avian IgY antibody microbeads using spin filters and HPLC multiple affinity ..
  75. pmc Discrimination of solvent from protein regions in native Fouriers as a means of evaluating heavy-atom solutions in the MIR and MAD methods
    T C Terwilliger
    Structural Biology Group, Mail Stop M888, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Acta Crystallogr D Biol Crystallogr 55:501-5. 1999
    ..examination of the native Fourier is tested as a means of evaluation of a heavy-atom solution in MAD and MIR methods for macromolecular crystallography...
  76. ncbi Core temperature measurement: methods and current insights
    Daniel S Moran
    Military Physiology Unit, Heller Institute of Medical Research, Sheba Medical Center, Tel Hashomer, Israel
    Sports Med 32:879-85. 2002
    ..Monitoring internal body T(c) accurately requires invasive methods of measurement...
  77. ncbi Comparisons of site- and haplotype-frequency methods for detecting positive selection
    Kai Zeng
    State Key Laboratory of Biocontrol and Key Laboratory of Gene Engineering of the Ministry of Education, Sun Yat Sen University, Guangzhou, China
    Mol Biol Evol 24:1562-74. 2007
    ..In the companion paper (Zeng K, Shi S, Wu C-I, in preparation), we use the EW test to devise 2 compound tests, which are more powerful in detecting positive selection than DH, but are also relatively insensitive to demography...
  78. ncbi A critical comparison of methods for the determination of the aging sensitivity in biomedical grade yttria-stabilized zirconia
    Sylvain Deville
    Materials Science Department, National Institute of Applied Sciences GEMPPM INSA, Associate Research Unit 5510, 20 av A Einstein, 69621 Villeurbanne Cedex, France
    J Biomed Mater Res B Appl Biomater 72:239-45. 2005
    ..The expected outputs of conventional methods, that is, X-ray diffraction and scanning electron microscopy are examined...
  79. ncbi Multi-list methods using incomplete lists in closed populations
    Jason Sutherland
    Department of Statistics and Actuarial Science, Simon Fraser University, Burnaby, British Columbia, V5A 1S6, Canada
    Biometrics 61:134-40. 2005
    Multi-list methods have become a common application of capture-recapture methodology to estimate the size of human populations, and have been successfully applied to estimating prevalence of diabetes, human immunodeficiency virus (HIV), ..
  80. ncbi Assessing health related quality of life in medicine. An overview over concepts, methods and applications in international research
    Monika Bullinger
    Department of Medical Psychology, University of Hamburg, Germany
    Restor Neurol Neurosci 20:93-101. 2002
    ..Focus of attention are conceptual, methodological and practical challenges as well as the contribution of quality of life research to evaluating the results of medical treatment...
  81. ncbi Methods for estimation of bone marrow plasma cell involvement in myeloma: predictive value for response and survival in patients undergoing autologous stem cell transplantation
    S V Rajkumar
    Division of Hematology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Hematol 68:269-75. 2001
    ..There was a significant correlation between the three methods, rho > 0.65, P < 0.001...
  82. pmc Threshold-free high-power methods for the ontological analysis of genome-wide gene-expression studies
    Bjorn Nilsson
    Department of Clinical Genetics, Lund University Hospital, SE 221 85 Lund, Sweden
    Genome Biol 8:R74. 2007
    Ontological analysis facilitates the interpretation of microarray data. Here we describe new ontological analysis methods which, unlike existing approaches, are threshold-free and statistically powerful...
  83. ncbi Timing the changes of cyclin E cell content in G1 in exponentially growing cells
    Daniela Tomasoni
    Biophysics Unit, Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    Exp Cell Res 288:158-67. 2003
    ..This way we could calculate the average cyclin E content of cells in each age cohort. Cyclin E values were low until age 3 h, after which they rose gradually, reaching six times the value of newborn cells at the end of G(1)...
  84. ncbi Comparison of two methods for predicting equilibrated Kt/V (eKt/V) using true eKt/V value
    O Marsenic
    Pediatr Nephrol 13:418-22. 1999
    Two methods have been suggested by Daugirdas and Schneditz (the rate equation), and Smye for predicting true equilibrated Kt/V (eKt/V) without the need for obtaining a blood sample 60 min after hemodialysis (HD)...
  85. ncbi Suicidal and homicidal deaths: a comparative and circumstantial approach
    Vipul Namdeorao Ambade
    Department of Forensic Medicine, Vasantrao Naik Medical College, Yeotmal 445 001, Maharashtra, India
    J Forensic Leg Med 14:253-60. 2007
    ..9/100,000 per year. Poisoning, burning, hanging and drowning forms the major methods of suicide in contrast to blunt trauma, sharp trauma, burning, and strangulation in homicide...
  86. ncbi Suicide in India: a four year retrospective study
    Sachidananda Mohanty
    Department of Forensic Medicine and Toxicology, MKCG Medical College, Berhampur, Orissa, India
    J Forensic Leg Med 14:185-9. 2007
    ..All the cases were analyzed as to sex, age, and methods of suicide, seasonal variation, diurnal variation and other sociological aspects...
  87. ncbi Suicides in Northern India: comparison of trends and review of literature
    B R Sharma
    Department of Forensic Medicine and Toxicology, Government Medical College and Hospital, 1156 B, Sector 32 B, Chandigarh, India
    J Forensic Leg Med 14:318-26. 2007
    ....
  88. ncbi Suicide - a statistical analysis by age, sex and method
    J P Henderson
    London South Bank University, Forensic Science Unit, School of Applied Science, Faculty of Engineering, Science and Technology, UK
    J Clin Forensic Med 12:305-9. 2005
    ..Good agreement was found between the results of this study and those of the Home Office Study...
  89. ncbi Nonnatural deaths of adolescents and teenagers: Fulton County, Georgia, 1985-2004
    Michael Heninger
    Fulton County Medical Examiner s Center and daggerEmory University School of Medicine, Atlanta, GA, USA
    Am J Forensic Med Pathol 29:208-13. 2008
    ..Characterizing the causes and circumstances of nonnatural childhood deaths may provide information that is useful for development of prevention strategies and programs...
  90. ncbi An unusual mechanical asphyxia in a homicide-suicide case by smothering and strangulation
    Emanuela Turillazzi
    From the Institute of Forensic Pathology, University of Foggia, Policlinico Ospedali Riuniti, Foggia, Italy
    Am J Forensic Med Pathol 27:166-8. 2006
    ....
  91. ncbi Youth suicide in New Mexico: a 26-year retrospective review
    Veena D Singh
    New Mexico Office of the Medical Investigator, MSC11 6030, 1 University of New Mexico, Albuquerque, NM 87131, USA
    J Forensic Sci 53:703-8. 2008
    ..With a solid understanding of the circumstances, it may be possible to predict, and hopefully prevent, future cases of child and adolescent death...
  92. ncbi Suicidal hanging: fatalities in Istanbul retrospective analysis of 761 autopsy cases
    Ibrahim Uzun
    The Ministry of Justice, Institute of Forensic Medicine, Istanbul, Turkey
    J Forensic Leg Med 14:406-9. 2007
    ..Hyperemic lines around the ligature were prominent in 620 of the cases and soft tissue ecchymoses in all cases. In 305 of the cases (40.07%) diagnosis was based only on the soft tissue hemorrhage...
  93. ncbi A study of suicides in Londonderry, Northern Ireland, for the year period spanning 2000-2005
    Amanda Burns
    University of Ulster, Rm W1057, CMB, Cromore Road, Coleraine, Northern Ireland BT52 1SA, UK
    J Forensic Leg Med 15:148-57. 2008
    ..The most frequent method of suicide recorded in this study was hanging (55%). The next most frequent methods were drowning (25%) and overdose (13.3%). Three times as many males (6) overdosed compared to females.
  94. ncbi Suicide methods in the elderly in South Australia 1981-2000
    R W Byard
    Forensic Science Centre, 21 Divett Place, Adelaide, SA 5000, Australia
    J Clin Forensic Med 11:71-4. 2004
    ..01). Female victims tended to avoid violent methods such as gunshot wounds in favour of drug overdose...
  95. ncbi Deaths among criminal suspects, law enforcement officers, civilians, and prison inmates: a coroner-based study
    Steven A Koehler
    Allegheny County Coroner s Office, Pittsburgh, PA 15219, USA
    Am J Forensic Med Pathol 24:334-8. 2003
    ....
  96. ncbi The risk factors of suicide by poisoning among psychiatry department outpatients
    Ken Inoue
    J Forensic Leg Med 15:65-7. 2008
  97. ncbi Suicide and the war in Croatia
    A Bosnar
    Institute of Forensic Medicine, Faculty of Medicine Rijeka, Brace Branchetta 20, 51000 Rijeka, Croatia
    Forensic Sci Int 147:S13-6. 2005
    ..The level of alcohol intoxication of perpetrators at the moment of suicide significantly increased in the wartime period. War had a direct impact on quantitative and qualitative characteristics of suicides in Croatia...
  98. ncbi Fatal suicide cases from 1991 to 2000 in Szeged, Hungary
    B Havasi
    Department of Forensic Medicine, University of Szeged, 6722 Szeged, Kossuth L sgt 40, Hungary
    Forensic Sci Int 147:S25-8. 2005
    ..8% of the 474 victims whose blood and/or urine alcohol concentration measurement were carried out consumed alcohol prior to the act. The presence of licit drugs in 12% of not drug-related cases were experienced...
  99. ncbi Suicide in children and adolescents: a 10-year retrospective review
    Danielle Shaw
    Department of Pathology and Laboratory Medicine, McMaster University Medical Center, Hamilton, Ontario, Canada
    Am J Forensic Med Pathol 26:309-15. 2005
    ..Overall, the method of suicide is dictated by what is convenient and readily available, though the acceptance of various suicide methods can change over time. Suicide prevention efforts should be tailored to address local trends.
  100. ncbi Presence of alcohol in suicide victims
    M Bilban
    Institute of Occupational Safety, SI 1000 Ljubljana, Chengdujska casta 25, Slovenia
    Forensic Sci Int 147:S9-12. 2005
    ..Simultaneously, due to an established link, the national alcohol policy and strategy for prevention of suicides should be professionally harmonized...
  101. ncbi Suicidal deaths in childhood and adolescence
    Hasan Agritmis
    Institute of Forensic Medicine, Ministry of Justice, 31243 Cerrahpaşa, Istanbul, Turkey
    Forensic Sci Int 142:25-31. 2004
    ....

Research Grants63

  1. THE AGRICULTURAL HEALTH STUDY - FIELD STATIONS
    Charles Lynch; Fiscal Year: 2010
    ..Several feasibility studies have been conducted among migrant and seasonal farm workers to determine appropriate methods for epidemiologic investigations in this understudied group...
  2. NIEHS SUPPORT OF THE AHS COHORT STUDY AT NCI
    Charles Knott; Fiscal Year: 2010
    ..Several feasibility studies have been conducted among migrant and seasonal farm workers to determine appropriate methods for epidemiologic investigations in this understudied group...
  3. ED Disability Diagnostic Tool: An HIT Feasibility Study
    Lori Ann Post; Fiscal Year: 2013
    ..abstract_text> ..
  4. National Study of Disability Trends and Dynamics
    Judith Kasper; Fiscal Year: 2013
    ..A high priority will be placed on timely distribution of high-quality, user-friendly, and well-documented data files and on building a broad user base. ..
  5. EPIDEMIOLOGY OF ALCOHOL PROBLEMS
    Thomas K Greenfield; Fiscal Year: 2013
    ..influences like family and friends, and regulations;c) gather and analyze research data in ways that advance methods and test competing hypotheses;d) disseminate this information and translate findings needed by target audiences ..
  6. A Novel Bayesian Model Averaging Approach for Genome Wide Association Studies
    Michael D Swartz; Fiscal Year: 2010
    ..To uncover the genetic etiology for cancers and other complex diseases or traits, it is necessary to use methods that jointly consider multiple genetic components underlying the disease...
  7. ELDER PAIN--ASSESSMENT OF INTENSITY
    Keela Herr; Fiscal Year: 1999
    ..The long term objectives of the P.I. are to establish accurate pain assessment methods for the elderly and ultimately, to test interventions used to relieve pain or its impact in the elderly...
  8. Comparative Effectiveness of Alcohol Treatments
    Georgiy Bobashev; Fiscal Year: 2011
    ..abstract_text> ..
  9. PERIODONTITIS AND SYSTEMIC DISEASE: CONFOUNDING?
    Philippe Hujoel; Fiscal Year: 2001
    ..The investigators believe the completion of these projects may play a pivotal role in determining whether the previously observed associations between periodontitis and systemic diseases are spurious or causal. ..
  10. Strategies for the Syntheses of Bioactive Targets
    Stephen Martin; Fiscal Year: 2010
    ..provided by applicant): The overall goal of this research program is to develop new and broadly useful methods and strategies and to apply these to the concise and efficient syntheses of biologically-active, heterocyclic ..
  11. COMPONENTS OF PRENATAL CARE AND LOW BIRTHWEIGHT
    Shirley Beresford; Fiscal Year: 1991
    ....
  12. PALLADIUM CATALYZED FORMATION OF ARYLAMINE AND ARYLETHER
    John Hartwig; Fiscal Year: 2000
    ..new reaction procedures, amide reagents, and palladium catalysts that significantly improve upon published methods. The research described in this proposal stems from these recent synthetic advances and includes the following ..
  13. ETHNOGRAPHY OF THERAPEUTIC PROCESS IN RELIGIOUS HEALING
    CSORDAS THOMAS; Fiscal Year: 2001
    ....
  14. Cross-Coupling Reactions of Organosilanols
    SCOTT DENMARK; Fiscal Year: 2009
    ..The first involves the development of new and general methods for the introduction of the silanol (or its surrogate) into organic structures using direct installation, cross- ..
  15. Testing Measures of Maternal and Infant Circadian Rhythm
    Karen Thomas; Fiscal Year: 2005
    ..Aims include determining the sensitivity threshold setting for computer scored actigraphy in infants, developing methods and protocols for performing actigraphy in mothers and infants collecting infant urinary 6-sulfatoxymelatonin in ..
  16. SYNTHESIS OF AMINO ACID-DERIVED NATURAL PRODUCTS
    David Evans; Fiscal Year: 2000
    ..of the cephalosporin, carbacephalosporin, and oxacephalosporin antibiotics through catalytic asymmetric synthesis methods. We will also determine the structure and develop an asymmetric synthesis of the hexapeptide complestatin, the ..
  17. Improving Alcohol Consumption Self-Report Measurement
    Thomas Greenfield; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  18. Tandem Cycloaddition Chemistry of 2-Azoniaheterodienes
    SCOTT DENMARK; Fiscal Year: 2007
    ..abstract_text> ..
  19. SYNTHESIS OF NITROGEN CONTAINING NATURAL PRODUCTS
    Stephen Martin; Fiscal Year: 2010
    ..provided by applicant): The goal of this proposed program is to develop new and broadly useful synthetic methods and strategies and apply these to preparing biologically active alkaloids and other nitrogen containing compounds ..
  20. CHILDREN'S MECHANISMS FOR VARYING VOCAL INTENSITY
    Elaine Stathopoulos; Fiscal Year: 1993
    ....
  21. STRESS AND BLOOD PRESSURE--LAB AND NATURAL SETTINGS
    David Shapiro; Fiscal Year: 1991
    ..variability indices, day-by-day and year- by-year consistency of ambulatory records, investigation of different methods of quantifying and analyzing pressure level and variability...
  22. COGNITIVE STRATEGIES USED TO RECALL HIGH RISK BEHAVIORS
    Laura Bogart; Fiscal Year: 2001
    ..Information about these cognitive strategies will ultimately be used to develop more reliable and valid assessments of sexual behavior that incorporate interviewers probes, cues, and contexts to aid recall. ..
  23. HOME CARE MONITORING OF HIV EXPOSED CHILDREN
    Mary Byrne; Fiscal Year: 2000
    ....
  24. ORGANOMANGANESE REAGENTS IN ORGANIC SYNTHESIS
    Philip DeShong; Fiscal Year: 1991
    ..The compounds synthesized during this investigation will serve as model compounds for the total synthesis of vineomycin B, pluramycin, chrysomycin B, lasolocid and monensin...
  25. GENDER DIFFERENCES IN PATTERNS OF CHRONIC ANGINAL PAIN
    Laura Kimble; Fiscal Year: 2001
    ..Secondary research questions address factors that influence nitroglycerin use. ..
  26. ASYMMETRIC SYNTHESIS OF IONOPHORE/MACROLIDE ANTIBIOTICS
    David Evans; Fiscal Year: 2005
    ..Our goal has been to set in place all of the reactions necessary for the rapid assemblage of any polyketide target structure. ..
  27. EPIDEMIOLOGY OF ALCOHOL PROBLEMS
    Thomas K Greenfield; Fiscal Year: 2010
    ..policy responses;c) to analyze person, alcohol intake, and environmental data in new ways that advance methods and test key hypotheses;d) to disseminate this information and systematically translate needed findings to reach ..
  28. Measurement & Use of Utilities in Ovarian Cancer CEA
    Deborah Dobrez; Fiscal Year: 2003
    ..This methodological study will focus on the improvement of cost- effectiveness methods through both the better measurement and use of utilities in CFAs, providing information that is generalizable ..
  29. NLS RESURVEY--OLDER MALE SURVIVORS & DECEDENTS WIDOWS
    HERBERT PARNES; Fiscal Year: 1991
    ..A summary report analyzing descriptive data on the topics described above will be completed by November 30,1991...
  30. BASAL FOREBRAIN ORGANIZATION
    Lennart Heimer; Fiscal Year: 1980
    ..previously employed in this research has been supplemented, and partly replaced by more sensitive experimental methods, some of which have been developed in our laboratory...
  31. NATURAL PRODUCT SYNTHESIS VIA CYCLOADDITION REACTIONS
    WILLIAM ROUSH; Fiscal Year: 2007
    ..Major sub-[unreadable] goals of this program are the development of strategies or methods for[unreadable] achieving high levels of stereochemical control i the IMDA reactions...
  32. ALTERNATIVE METHODS FOR CLINICAL RESEARCH
    Souraya Sidani; Fiscal Year: 2004
    ..Different research designs, treatment options, and measurement methods will be used to obtain a comprehensive data set...
  33. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2009
    ..Two new methods for accessing pyrans by simple one operation cycloaddition - like strategy relying on palladium and / or ..
  34. SYNTHESIS OF ANNONACEOUS ACETOGENINS AND ANALOGUES
    James Marshall; Fiscal Year: 2001
    ..The synthetic approach will employ chiral allylic and allenic organometal reagents to introduce stereogenic centers with concurrent formation of carbon-carbon bonds. ..
  35. Synthesis of Tumor Inhibitory Marine Natural Products
    James Marshall; Fiscal Year: 2004
    ..The main chemical issues to be addressed include the control of stereochemistry by means of chiral organometal chemistry and the design of new and efficient routes to structurally novel natural products. ..
  36. HEART IMAGING AGENTS--STRUCTURAL MECHANISTICS STUDY
    David Raffel; Fiscal Year: 2004
    ..Finally, [11C]- and [18F]-labeled polar derivatives of the psychostimulant methcathinone will be synthesized as potential NET markers and their in vitro NET affinities determined as the cloned human NET transporter. ..
  37. Protein arrays to profile cytokine expression in ovaria*
    Ruo Pan Huang; Fiscal Year: 2005
    ..The data will be analyzed using statistics and bioinformatics tool and correlated with pathological and clinical data. The successful outcome of this grant may impact on the development of new biomarkers for patient-care management. ..
  38. Hurricane Katrina Community Advisory Group
    Ronald C Kessler; Fiscal Year: 2010
    ....
  39. Signaling Pathways in Yeast Azole Response
    Thomas Edlind; Fiscal Year: 2005
    ..Finally, the signalling pathway responsible for azole-dependent upregulation of ERG expression will be elucidated with a focus on Rox1p and Haplp transcription factors. ..
  40. Enabling Technologies for Combinatorial Chemistry
    K Nicolaou; Fiscal Year: 2005
    ..abstract_text> ..
  41. TOTAL SYNTHESIS OF APOPTOLIDIN
    K Nicolaou; Fiscal Year: 2004
    ..The proposed work is expected to have significant impact in the area of cancer chemotherapy and should provide enabling technologies and tools for biology and medicine. ..
  42. Malt Liquor/Fortified Wine Use and Ethnicity in the U.S.
    Thomas Greenfield; Fiscal Year: 2003
    ..Last, we will explore spacial relationships between heavy use and alcohol-related victimization in communities as well as existing alcohol policies. Results inform culturally appropriate health messages and policy development. ..
  43. MENTAL DISORDERS AS RISK FACTORS FOR SUBSTANCE DISORDERS
    Ronald Kessler; Fiscal Year: 2003
    ....
  44. ADJUSTMENT OF INTERNATIONALLY ADOPTED CHILDREN
    Megan Gunnar; Fiscal Year: 2002
    ..This work will add significantly to our understanding of the health and behavioral sequelae of early adversity and th potential impact of early adversity on stress-sensitive limbic-hypothalamic processes. ..
  45. RADICAL REACTIONS FOR NATURAL PRODUCTS
    DENNIS CURRAN; Fiscal Year: 2002
    DESCRIPTION: (Applicant's Abstract) The development of new synthetic methods and reactions to synthesize drug candidates and other organic molecules of importance in health-related research is a continuing goal of great importance...
  46. The CFTR Degradation Pathway in Yeast
    JEFFREY BRODSKY; Fiscal Year: 2002
    ..pathway, CFTR-associated proteins will be identified by co-opting established yeast biochemical and proteomic methods. Analyzing the stability of CFTR in cells mutated or depleted for the corresponding genes will indicate which MR-..
  47. HEART IMAGING AGENTS--STRUCTURAL MECHANISTICS STUDY
    David Raffel; Fiscal Year: 2001
    ..Finally, [11C]- and [18F]-labeled polar derivatives of the psychostimulant methcathinone will be synthesized as potential NET markers and their in vitro NET affinities determined as the cloned human NET transporter. ..
  48. Tissue Engineering of Cartilage using Periosteum
    SHAWN O DRISCOLL; Fiscal Year: 2008
    ..In addition, by eliminating the need for cell culture expansion facilities and expertise, the cost of this approach should be considerably less thereby making cartilage repair more globally accessible. ..
  49. DIAGNOSTIC CRITERIA FOR ADOLESCENT ALCOHOL USE DISORDERS
    Tammy Chung; Fiscal Year: 2005
    ..The second area is advanced study of principles and methods of developmental psychopathology and developmental issues in psychiatric nosology...
  50. Paracrine Regulation of IGF-I in the Developing Ileum
    Phillip Gordon; Fiscal Year: 2006
    ..abstract_text> ..
  51. Developmental Psychobiology of Stress in Children
    Megan Gunnar; Fiscal Year: 2006
    ..Her career has been characterized by increasing integration of the literature on and methods of studying cortisol-behavior relations, with the literature and methods in the study of psychophysiological, ..
  52. Outreach and Treatment for Depression in the Labor Force
    Ronald Kessler; Fiscal Year: 2005
    ..The trial will be identical to others in outreach and care monitoring methods and in quality assurance...
  53. Psychobiological studies of stress in young children
    Megan Gunnar; Fiscal Year: 2005
    ..We argue that normative developmental research complements and provides basic data necessary for research and theory on developmental psychopathology. ..
  54. Statistical Methods for Identifying Genes Associated with Diabetes Development
    Yinglei Lai; Fiscal Year: 2007
    ..We will develop novel statistical methods based on the evaluations and comparisons of existing methods...
  55. Peptide Profiling Techniques to Detect Thyroid Carcinoma
    Paul Tempst; Fiscal Year: 2007
    ..of this project are to (i) automate our prototype serum peptide profiling platform and implement machine learning methods that use the resulting peptide patterns ('barcodes') for sample classification [R21]; and (ii) to test ..
  56. Micro-Thickness Collagen Membranes in Tissue Engineering
    Robert Vernon; Fiscal Year: 2007
    ..shorten TEBV fabrication times to a matter of days, rather than the weeks or months required by other methods. CMs populated with confluent, aligned human coronary artery SMCs (HCASMCs) will be wrapped around a mandrel to ..
  57. Skeletal Development in Clubfoot Treatment
    Sorin Siegler; Fiscal Year: 2007
    ..We view this proposal as the beginning of a longer term strategy to improve the nonoperative treatment of clubfoot and to explore the mechanisms by which these cartilage anlagen develop. [unreadable] [unreadable] [unreadable]..
  58. Yeast Gene Ontology by Phenotypic Profiling
    John Brown; Fiscal Year: 2007
    ..abstract_text> ..
  59. THE ROLE OF SULFATIDES IN ALZHEIMER'S DISEASE
    Xianlin Han; Fiscal Year: 2008
    ..abstract_text> ..
  60. Semiparametric ROC Curve Regression for Cancer Screening Studies
    Xiaofei Wang; Fiscal Year: 2008
    ..To fully accommodate the sampling schemes, we develop semi parametric methods to estimate the parameters of the covariate-specific ROC regression model for continuous screening tests...
  61. Identification of SV40 T Antigen Inhibitors: A Route to Novel Anti-Viral Reagent
    JEFFREY BRODSKY; Fiscal Year: 2008
    ..Through these efforts, a significant battery of in vitro methods have been developed that have been re-configured for a high throughput screen to identify new, more potent TAg ..
  62. Mutational Analysis of Fks1: Intrinsic Echinocandin Resistance
    Thomas D Edlind; Fiscal Year: 2010
    ..These studies will accelerate the development of second generation ECs that provide a broader spectrum of protection from fungal pathogens. ..