lymphocyte depletion

Summary

Summary: Immunosuppression by reduction of circulating lymphocytes or by T-cell depletion of bone marrow. The former may be accomplished in vivo by thoracic duct drainage or administration of antilymphocyte serum. The latter is performed ex vivo on bone marrow before its transplantation.

Top Publications

  1. ncbi Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    S Sakaguchi
    Precursory Research for Embryonic Science and Technology PRESTO, Research and Development Corporation of Japan JRDC, Tsukuba Life Science Center
    J Immunol 155:1151-64. 1995
  2. ncbi Cutting edge: depletion of Foxp3+ cells leads to induction of autoimmunity by specific ablation of regulatory T cells in genetically targeted mice
    Jeong Kim
    Department of Immunology, University of Washington, Seattle, WA 98195, USA
    J Immunol 183:7631-4. 2009
  3. pmc Transient depletion of regulatory T cells in transgenic mice reactivates virus-specific CD8+ T cells and reduces chronic retroviral set points
    Kirsten K Dietze
    Institute for Virology, University Clinics Essen, University of Duisburg Essen, 45122 Essen, Germany
    Proc Natl Acad Sci U S A 108:2420-5. 2011
  4. ncbi The regulatory T-cell response during acute retroviral infection is locally defined and controls the magnitude and duration of the virus-specific cytotoxic T-cell response
    Gennadiy Zelinskyy
    Institute for Virology, University Clinics in Essen, University of Duisburg Essen, Essen, Germany
    Blood 114:3199-207. 2009
  5. pmc Failure to suppress the expansion of the activated CD4 T cell population in interferon gamma-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis
    C Q Chu
    Trudeau Institute, Saranac Lake, New York 12983, USA
    J Exp Med 192:123-8. 2000
  6. pmc Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice
    Chang yun Hu
    Section of Endocrinology, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Invest 117:3857-67. 2007
  7. ncbi Maintenance of long-lived plasma cells and serological memory despite mature and memory B cell depletion during CD20 immunotherapy in mice
    David J DiLillo
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 180:361-71. 2008
  8. ncbi Clinical use of anti-CD25 antibody daclizumab to enhance immune responses to tumor antigen vaccination by targeting regulatory T cells
    Andrew J Rech
    Abramson Family Cancer Research Institute and the University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Ann N Y Acad Sci 1174:99-106. 2009
  9. ncbi Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma
    Katjana Klages
    Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Cancer Res 70:7788-99. 2010
  10. ncbi CD4+CD25+ regulatory T cells control the severity of viral immunoinflammatory lesions
    Susmit Suvas
    Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA
    J Immunol 172:4123-32. 2004

Detail Information

Publications341 found, 100 shown here

  1. ncbi Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    S Sakaguchi
    Precursory Research for Embryonic Science and Technology PRESTO, Research and Development Corporation of Japan JRDC, Tsukuba Life Science Center
    J Immunol 155:1151-64. 1995
    ..Abnormality of this T cell-mediated mechanism of peripheral tolerance can be a possible cause of various autoimmune diseases...
  2. ncbi Cutting edge: depletion of Foxp3+ cells leads to induction of autoimmunity by specific ablation of regulatory T cells in genetically targeted mice
    Jeong Kim
    Department of Immunology, University of Washington, Seattle, WA 98195, USA
    J Immunol 183:7631-4. 2009
    ..Autoimmunity can be reversed by the adoptive transfer of Tregs into depleted hosts, and the transfer of Foxp3-deficient bone marrow into T cell-deficient irradiated recipients leads to full-blown disease development...
  3. pmc Transient depletion of regulatory T cells in transgenic mice reactivates virus-specific CD8+ T cells and reduces chronic retroviral set points
    Kirsten K Dietze
    Institute for Virology, University Clinics Essen, University of Duisburg Essen, 45122 Essen, Germany
    Proc Natl Acad Sci U S A 108:2420-5. 2011
    ....
  4. ncbi The regulatory T-cell response during acute retroviral infection is locally defined and controls the magnitude and duration of the virus-specific cytotoxic T-cell response
    Gennadiy Zelinskyy
    Institute for Virology, University Clinics in Essen, University of Duisburg Essen, Essen, Germany
    Blood 114:3199-207. 2009
    ....
  5. pmc Failure to suppress the expansion of the activated CD4 T cell population in interferon gamma-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis
    C Q Chu
    Trudeau Institute, Saranac Lake, New York 12983, USA
    J Exp Med 192:123-8. 2000
    ..We thus present novel in vivo and in vitro evidence that IFN-gamma may limit the extent of EAE by suppressing expansion of activated CD4 T cells...
  6. pmc Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice
    Chang yun Hu
    Section of Endocrinology, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Invest 117:3857-67. 2007
    ..Our results demonstrate clinical efficacy even in established disease and identify mechanisms for therapeutic action that will guide design and evaluation of parallel studies in patients...
  7. ncbi Maintenance of long-lived plasma cells and serological memory despite mature and memory B cell depletion during CD20 immunotherapy in mice
    David J DiLillo
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 180:361-71. 2008
    ..Thereby, depleting mature and memory B cells does not have a dramatic negative effect on preexisting Ab levels...
  8. ncbi Clinical use of anti-CD25 antibody daclizumab to enhance immune responses to tumor antigen vaccination by targeting regulatory T cells
    Andrew J Rech
    Abramson Family Cancer Research Institute and the University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Ann N Y Acad Sci 1174:99-106. 2009
    ..If confirmed in additional patients, these observations suggest that daclizumab may be an effective and available therapeutic agent for Treg modulation in patients with cancer...
  9. ncbi Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma
    Katjana Klages
    Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Cancer Res 70:7788-99. 2010
    ..These findings might have implications for future therapeutic interventions in cancer patients...
  10. ncbi CD4+CD25+ regulatory T cells control the severity of viral immunoinflammatory lesions
    Susmit Suvas
    Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA
    J Immunol 172:4123-32. 2004
    ..Our results decipher the in vivo role of T(reg) in a virus-induced immunopathology and imply that manipulation of regulatory cell function represents a useful approach to control viral-induced immunoinflammatory disease...
  11. ncbi In vivo depletion of CD4+FOXP3+ Treg cells by the PC61 anti-CD25 monoclonal antibody is mediated by FcgammaRIII+ phagocytes
    Yulius Y Setiady
    ImmunoGen, Inc, Waltham, MA 02451, USA
    Eur J Immunol 40:780-6. 2010
    ..Altogether these data demonstrate the critical role of FcgammaRIII(+) phagocytes in mediating Treg depletion by PC61 mAb. This finding may be useful in guiding the development of human Treg targeting therapy...
  12. pmc Benefit from B-lymphocyte depletion using the anti-CD20 antibody rituximab in chronic fatigue syndrome. A double-blind and placebo-controlled study
    Øystein Fluge
    Department of Oncology and Medical Physics, Haukeland University Hospital, Bergen, Norway
    PLoS ONE 6:e26358. 2011
    ..relief during cancer chemotherapy in a patient with synchronous CFS and lymphoma spurred a pilot study of B-lymphocyte depletion using the anti-CD20 antibody Rituximab, which demonstrated significant clinical response in three CFS ..
  13. ncbi Efficient Treg depletion induces T-cell infiltration and rejection of large tumors
    Xingrui Li
    Division of Molecular Immunology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Eur J Immunol 40:3325-35. 2010
    ....
  14. pmc Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines
    Michael A Morse
    Department ofMedicine, Duke University Medical Center, Durham, NC 27710, USA
    Blood 112:610-8. 2008
    ....
  15. ncbi Conditional regulatory T-cell depletion releases adaptive immunity preventing carcinogenesis and suppressing established tumor growth
    Michele W L Teng
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Cancer Res 70:7800-9. 2010
    ..Tumor rejection occurred in the absence of overt autoimmunity, suggesting that effective transient Treg depletion strategies may be therapeutic in at least a proportion of spontaneous tumors developing in the host...
  16. ncbi NK cells stimulate recruitment of CXCR3+ T cells to the brain during Plasmodium berghei-mediated cerebral malaria
    Diana S Hansen
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Immunol 178:5779-88. 2007
    ....
  17. ncbi Circulating levels of B lymphocyte stimulator in patients with rheumatoid arthritis following rituximab treatment: relationships with B cell depletion, circulating antibodies, and clinical relapse
    Geraldine Cambridge
    University College London, London, UK
    Arthritis Rheum 54:723-32. 2006
    To assess the effects of B lymphocyte depletion on serum B lymphocyte stimulator (BLyS; trademark of Human Genome Sciences, Rockville, MD) levels in patients with rheumatoid arthritis (RA), and to assess the relationship of serum BLyS ..
  18. pmc FoxP3+CD4+ regulatory T cells play an important role in acute HIV-1 infection in humanized Rag2-/-gammaC-/- mice in vivo
    Qi Jiang
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, USA
    Blood 112:2858-68. 2008
    ..The DKO-hu HSC mouse will be a valuable model to study human Treg functions and their role in HIV-1 pathogenesis in vivo...
  19. ncbi Lymphocyte homeostasis following therapeutic lymphocyte depletion in multiple sclerosis
    Amanda L Cox
    Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
    Eur J Immunol 35:3332-42. 2005
    Following lymphocyte depletion, homeostatic mechanisms drive the reconstitution of lymphocytes...
  20. pmc Antibody isotype-specific engagement of Fcgamma receptors regulates B lymphocyte depletion during CD20 immunotherapy
    Yasuhito Hamaguchi
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Exp Med 203:743-53. 2006
    ..Thus, isotype-specific mAb interactions with distinct FcgammaRs contribute significantly to the effectiveness of CD20 mAbs in vivo, which may have important clinical implications for CD20 and other mAb-based therapies...
  21. ncbi Differential in vivo effects of rituximab on two B-cell subsets in cynomolgus monkeys
    Yulia Vugmeyster
    Bioanalytical Research and Development Department, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Int Immunopharmacol 3:1477-81. 2003
    ....
  22. ncbi CD25+ cell depletion hastens the onset of severe disease in collagen-induced arthritis
    Mary E Morgan
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 48:1452-60. 2003
    ..We wished to evaluate their potential for influencing systemic and chronic joint inflammation by investigating their involvement in collagen-induced arthritis (CIA)...
  23. pmc A predominant role for antibody in acquired immunity to chlamydial genital tract reinfection
    Sandra G Morrison
    Division of Infectious Diseases, Department of Medicine, University of Alabama, Birmingham 35294 0007, USA
    J Immunol 175:7536-42. 2005
    ..These results impact our understanding of immunity to chlamydial genital infection and may provide important insight into vaccine development...
  24. pmc CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function
    Ian P Lewkowich
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Exp Med 202:1549-61. 2005
    ..These data suggest that resistance to allergen-driven AHR is mediated in part by CD4+CD25+ T reg cell suppression of DC activation and that the absence of this regulatory pathway contributes to susceptibility...
  25. ncbi Soluble type II transforming growth factor-beta receptor inhibits established murine malignant mesothelioma tumor growth by augmenting host antitumor immunity
    Eiji Suzuki
    Thoracic Oncology Research Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Clin Cancer Res 10:5907-18. 2004
    ..The purpose of this study was to explore the possible therapeutic utility of TGF-beta blockade on MM...
  26. pmc Changes in macrophage function after rituximab treatment in patients with rheumatoid arthritis
    E Toubi
    Division of Clinical Immunology and Allergy, Bnai Zion Medical Center, P O Box 4940, Haifa 31048, Israel
    Ann Rheum Dis 66:818-20. 2007
    ..To assess changes in macrophage phenotype and function after rituximab-induced B cell depletion in patients with rheumatoid arthritis (RA)...
  27. pmc Do CD4+ CD25+ immunoregulatory T cells hinder tumor immunotherapy?
    Paul Andrew Antony
    Surgery Branch, National Cancer Institute, Building 10, Room 2B42, 9000 Rockville Pike, Bethesda, MD 20892, USA
    J Immunother 25:202-6. 2002
    ..The challenge for immunotherapists now is to overcome immunosuppression using the knowledge gained through the understanding of T regulatory cell function...
  28. pmc A novel adoptive transfer model of chronic lymphocytic leukemia suggests a key role for T lymphocytes in the disease
    Davide Bagnara
    The Feinstein Institute for Medical Research, North Shore LIJ Health System, 350 Community Drive, Manhasset, NY 11030, USA
    Blood 117:5463-72. 2011
    ....
  29. ncbi Depletion of B cells in murine lupus: efficacy and resistance
    Anupama Ahuja
    Department of Laboratory Medicine, Yale University, New Haven, CT 06510, USA
    J Immunol 179:3351-61. 2007
    ..Thus, whereas successful B cell depletion is a promising therapy for lupus, at least some patients might be resistant to the therapy as a byproduct of the autoimmune condition itself...
  30. ncbi Interleukin-7: master regulator of peripheral T-cell homeostasis?
    T J Fry
    Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 13N240, 10 Center Drive, MSC 1928, Bethesda, MD 20892 1928, USA
    Trends Immunol 22:564-71. 2001
    ....
  31. ncbi Selective depletion of Foxp3+ Treg during sensitization phase aggravates experimental allergic airway inflammation
    Abdul Mannan Baru
    Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research a joint venture between the Helmholtz Centre for Infection Research HZI Braunschweig and the Hannover Medical School MHH, Germany
    Eur J Immunol 40:2259-66. 2010
    ....
  32. ncbi Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells
    C A Chambers
    Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, University of California, Berkeley 94720, USA
    Immunity 7:885-95. 1997
    ..These results demonstrate that CD4+ T cells initiate the phenotype in the CTLA-4(-/-) mice. Further, these results suggest that the role of CTLA-4 in peripheral CD4+ versus CD8+ T cell homeostasis is distinct...
  33. ncbi Mechanisms of action of antithymocyte globulin: T-cell depletion and beyond
    M Mohty
    Unité de Transplantation et de Thérapie Cellulaire UTTC, Institut Paoli Calmettes, Marseille, France
    Leukemia 21:1387-94. 2007
    ....
  34. ncbi Comment on "Cutting edge: anti-CD25 monoclonal antibody injection results in the functional inactivation, not depletion, of CD4+CD25+ T regulatory cells"
    Santiago Zelenay
    J Immunol 177:2036-7; author reply 2037-8. 2006
  35. pmc Experience with rituximab in scleroderma: results from a 1-year, proof-of-principle study
    Dimitrios Daoussis
    Division of Rheumatology, Department of Internal Medicine, Patras University Hospital, 26504 Rion, Patras, Greece
    Rheumatology (Oxford) 49:271-80. 2010
    ..To assess the efficacy of rituximab (RTX) in SSc...
  36. pmc Comparative methodologies of regulatory T cell depletion in a murine melanoma model
    Norimasa Matsushita
    H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, SRB 23244, Tampa, Florida 33612, United States
    J Immunol Methods 333:167-79. 2008
    ..We therefore conclude that PC61 administration was the most effective method of reducing Tregs in a murine melanoma model in addition to providing evidence of a synergistic effect when combined with DC-based immunotherapy...
  37. ncbi Combination of tumor site-located CTL-associated antigen-4 blockade and systemic regulatory T-cell depletion induces tumor-destructive immune responses
    Sebastian Tuve
    Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Cancer Res 67:5929-39. 2007
    ..Importantly, no signs of autoimmunity were detected in mice that received local CTLA-4 blockade alone or in combination with Treg depletion...
  38. pmc The role of T cells in the enhancement of respiratory syncytial virus infection severity during adult reinfection of neonatally sensitized mice
    John S Tregoning
    Section of Respiratory Infections, Centre for Respiratory Infections Research, National Heart and Lung Institute, St Mary s Campus of Imperial College, Norfolk Place, Paddington, London W2 1PG, United Kingdom
    J Virol 82:4115-24. 2008
    ..These findings demonstrate a crucial role for T cells in the regulation of immune responses after neonatal infection...
  39. pmc Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes
    Mark E Dudley
    Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20902, USA
    Science 298:850-4. 2002
    ..This approach presents new possibilities for the treatment of patients with cancer as well as patients with human immunodeficiency virus-related acquired immunodeficiency syndrome and other infectious diseases...
  40. ncbi A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses
    Koichi Yanaba
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Immunity 28:639-50. 2008
    ..Thereby, CD1d(hi)CD5(+) B cells represent a unique subset of potent regulatory B cells...
  41. pmc Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumor in vivo
    A Cerwenka
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, CA 94143-0414, USA
    Proc Natl Acad Sci U S A 98:11521-6. 2001
    ..Therefore, NK cells are able to reject a tumor expressing RAE-1 molecules, despite expression of self MHC class I on the tumor, demonstrating the potential for NK cells to participate in immunity against class I-bearing malignancies...
  42. pmc Profound CD4+/CCR5+ T cell expansion is induced by CD8+ lymphocyte depletion but does not account for accelerated SIV pathogenesis
    Afam Okoye
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006, USA
    J Exp Med 206:1575-88. 2009
    ..However, we report that CD8(+) lymphocyte depletion is also associated with a dramatic induction of proliferation among CD4(+) effector memory T (T(EM)) cells ..
  43. pmc In vivo natural killer cell depletion during primary simian immunodeficiency virus infection in rhesus monkeys
    Elisa I Choi
    Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    J Virol 82:6758-61. 2008
    ..These findings are consistent with a limited role for cytotoxic CD16(+) NK cells in the control of primary SIV viremia...
  44. pmc Novel human transitional B cell populations revealed by B cell depletion therapy
    Arumugam Palanichamy
    Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 182:5982-93. 2009
    ..The characterization of multiple transitional B cell subpopulations provides important insights into human B cell development...
  45. ncbi Depletion of regulatory T cells by anti-GITR mAb as a novel mechanism for cancer immunotherapy
    David Coe
    Department of Immunology, Imperial College London, Hammersmith Hospital, London, UK
    Cancer Immunol Immunother 59:1367-77. 2010
    ..Thus, depletion of Treg cells represents a previously unrecognised in vivo activity of DTA-1 which has important implications for the application of anti-GITR antibodies in cancer immunotherapy...
  46. pmc Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8+ T cells via TLR4 signaling
    Chrystal M Paulos
    National Cancer Institute NCI, NIH, Bethesda, Maryland 20892 1502, USA
    J Clin Invest 117:2197-204. 2007
    ..Thus, disruption of the homeostatic balance between the host and microbes can enhance cell-based tumor immunotherapy...
  47. ncbi Regulatory T cells suppress CD8+ T cell responses induced by direct priming and cross-priming and moderate immunodominance disparities
    S M Mansour Haeryfar
    Laboratory of Viral Diseases, National Institute of Allergies and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 174:3344-51. 2005
    ..Therefore, Treg influence TCD8 immunodominance hierarchies by moderating disparities in responses to different determinants...
  48. ncbi Damage control, rather than unresponsiveness, effected by protective DX5+ T cells in autoimmune diabetes
    A Gonzalez
    Institut de Genetique et de Biologie Moleculaire et Cellulaire CNRS INSERM ULP, Strasbourg, France
    Nat Immunol 2:1117-25. 2001
    ..5 cells, permitting their full activation and attack of pancreatic islets; rather, it tempered the aggressiveness of the insulitic lesion and the extent of beta cell destruction...
  49. ncbi Antigenic modulation limits the efficacy of anti-CD20 antibodies: implications for antibody selection
    Stephen A Beers
    Tenovus Laboratory, Cancer Sciences Division, The Netherlands
    Blood 115:5191-201. 2010
    ..We postulate that differences in CD20 modulation may play a central role in determining the relative efficacy of rituximab in treating these diseases and strengthen the case for focusing on type II anti-CD20 mAb in the clinic...
  50. ncbi Regulatory T cells in immune surveillance and treatment of cancer
    Tomoyuki Yamaguchi
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, 53 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Semin Cancer Biol 16:115-23. 2006
    ..A combination of depletion or attenuation of T(R) cells and concomitant stimulation of effector T cells, systemically or locally in tumors, may be a feasible immunotherapy for cancer...
  51. ncbi IL-2 immunotoxin therapy modulates tumor-associated regulatory T cells and leads to lasting immune-mediated rejection of breast cancers in neu-transgenic mice
    Keith L Knutson
    Department of Immunology, Mayo Clinic College of Medicine, 342C Guggenheim, 200 First Street SW, Rochester, MN 55905, USA
    J Immunol 177:84-91. 2006
    ....
  52. pmc T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosis
    Zhenyue Hao
    620 University Ave, Toronto, ON, M5G 2C1, Canada
    J Exp Med 199:1355-65. 2004
    ....
  53. ncbi T regulatory cells contribute to the attenuated primary CD8+ and CD4+ T cell responses to herpes simplex virus type 2 in neonatal mice
    Marian A Fernandez
    Centre for Perinatal Infection Research, The Children s Hospital at Westmead, Westmead, New South Wales 2145, Australia
    J Immunol 180:1556-64. 2008
    ..i. compared with uninfected neonates, but IL-10 was increased in infected adults alone. These experiments support the notion that the newborn primary T cell effector responses to HSV are suppressed by Tregs...
  54. ncbi B cell depletion as a novel treatment for systemic lupus erythematosus: a phase I/II dose-escalation trial of rituximab
    R John Looney
    University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Arthritis Rheum 50:2580-9. 2004
    ..B lymphocytes have been shown to play fundamental pathogenic roles in SLE, and therefore, elimination of B cells with the use of rituximab may represent a new therapy for SLE...
  55. ncbi Therapy-induced antitumor vaccination by targeting tumor necrosis factor alpha to tumor vessels in combination with melphalan
    Lorenzo Mortara
    Department of Clinical and Biological Sciences, School of Medicine, University of Insubria, Varese, Italy
    Eur J Immunol 37:3381-92. 2007
    ....
  56. ncbi Complement activation determines the therapeutic activity of rituximab in vivo
    Nicola Di Gaetano
    Department of Immunology and Cell Biology, Istituto Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Immunol 171:1581-7. 2003
    ..These data demonstrate that C activation is fundamental for rituximab therapeutic activity in vivo...
  57. pmc Rituximab induces sustained reduction of pathogenic B cells in patients with peripheral nervous system autoimmunity
    Michael A Maurer
    Institute of Experimental Immunology, Department of Neuroinflammation, University of Zurich, Zurich, Switzerland
    J Clin Invest 122:1393-402. 2012
    ..These findings support the continued development of B cell-depleting therapies for autoimmune diseases...
  58. ncbi CD4+ T Lymphocytes, especially Th2 cells, contribute to the progress of renal fibrosis
    Lili Liu
    Division of Nephrology, Department of Internal Medicine, Tongji Hospital, PR China
    Am J Nephrol 36:386-96. 2012
    ..But the role of CD4+ T lymphocytes in renal fibrosis is controversial and its cellular mechanism needs to be further investigated...
  59. ncbi Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes
    J E Schmitz
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Science 283:857-60. 1999
    ..These results confirm the importance of cell-mediated immunity in controlling HIV-1 infection and support the exploration of vaccination approaches for preventing infection that will elicit these immune responses...
  60. pmc IL-21 drives secondary autoimmunity in patients with multiple sclerosis, following therapeutic lymphocyte depletion with alemtuzumab (Campath-1H)
    Joanne L Jones
    Department of Clinical Neuroscience, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Clin Invest 119:2052-61. 2009
    ..arose in those patients with greater T cell apoptosis and cell cycling in response to alemtuzumab-induced lymphocyte depletion, a phenomenon that is driven by higher levels of IL-21...
  61. ncbi The rationale for B lymphocyte depletion in Graves' disease. Monoclonal anti-CD20 antibody therapy as a novel treatment option
    Daniel El Fassi
    Department of Endocrinology and Metabolism, Odense University Hospital, Denmark
    Eur J Endocrinol 154:623-32. 2006
    ....
  62. ncbi Depletion of CD4+CD25+ regulatory T cells promotes a tumor-specific immune response in pancreas cancer-bearing mice
    Carsten T Viehl
    Department of Surgery, Washington University School of Medicine, Box 8109, 660 S Euclid Ave, St Louis, Missouri 63110, USA
    Ann Surg Oncol 13:1252-8. 2006
    ..Depletion of T(reg) results in smaller tumors and prolonged host survival. The objective of this study was to evaluate the tumor-specific immune response after depletion of T(reg) alone or in combination with a cancer vaccine...
  63. pmc Cell-intrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo
    Roberto Tinoco
    Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093 0322, USA
    Immunity 31:145-57. 2009
    ..Our findings reveal persisting TGF-beta-Smad signaling as a hallmark and key regulator of CD8(+) T cell responses during chronic viral infections in vivo...
  64. ncbi Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: implications for T-cell homeostasis
    L A Napolitano
    Gladstone Institute of Virology and Immunology, San Francisco General Hospital, and Department of Medicine, University of California at San Francisco, San Francisco, California 94110-9100, USA
    Nat Med 7:73-9. 2001
    ..We propose that IL-7 production increases as part of a homeostatic response to T-cell depletion...
  65. ncbi Role of CD4 T cell help and costimulation in CD8 T cell responses during Listeria monocytogenes infection
    Devon J Shedlock
    Department of Microbiology, School of Medicine, University of Pennsylvania, 3610 Hamilton Walk, Philadelphia, PA 19104 6076, USA
    J Immunol 170:2053-63. 2003
    ....
  66. pmc Depletion of CD4+CD25+ regulatory T cells enhances natural killer T cell-mediated anti-tumour immunity in a murine mammary breast cancer model
    H Hong
    School of Pharmaceutical Science, Sun Yet Sen University, Guangzhou, China
    Clin Exp Immunol 159:93-9. 2010
    ..Our results imply a potential application of combining T(reg) cell depletion with alpha-GalCer to stimulate NK T cells for cancer therapy...
  67. ncbi CD8 T cells inhibit respiratory syncytial virus (RSV) vaccine-enhanced disease
    Matthew R Olson
    Department of Microbiology, University of Iowa, IA 52242, USA
    J Immunol 179:5415-24. 2007
    ..Our results suggest that the failure of the FI-RSV vaccine to induce a CD8 T cell response may have contributed to the development of pulmonary eosinophilia and augmented disease that occurred in vaccinated individuals...
  68. ncbi CD4+CD25+ T cells regulate airway eosinophilic inflammation by modulating the Th2 cell phenotype
    Zeina Jaffar
    Center for Environmental Health Sciences, University of Montana, Missoula, MT 59812, USA
    J Immunol 172:3842-9. 2004
    ..Conceivably, this is partly a consequence of regulatory T cells facilitating the production of IL-10...
  69. ncbi Late-onset neutropenia following rituximab therapy in rheumatic diseases: association with B lymphocyte depletion and infections
    Daniel Tesfa
    Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden
    Arthritis Rheum 63:2209-14. 2011
    ..The purpose of this study was to define the incidence, clinical features, and some of the underlying mechanisms of late-onset neutropenia in relation to rituximab use in several rheumatic diseases...
  70. pmc B cell depletion in diffuse progressive systemic sclerosis: safety, skin score modification and IL-6 modulation in an up to thirty-six months follow-up open-label trial
    Silvia Bosello
    Division of Rheumatology, Catholic University, Medical School, Via G, Moscati, 31 Rome, 00168, Italy
    Arthritis Res Ther 12:R54. 2010
    ....
  71. pmc Induction of self-antigen-specific Foxp3+ regulatory T cells in the periphery by lymphodepletion treatment with anti-mouse thymocyte globulin in mice
    Yan Lu
    Department of Microbiology and Immunology Diabetes Research Institute Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Immunology 134:50-9. 2011
    ..This study provides in vivo evidence for clonal conversion from a pathogenic self-antigen-specific Teff cell to a Treg cell in the setting of immunodepletion therapies...
  72. pmc Lymphocyte depletion with fludarabine in patients with psoriatic arthritis: clinical and immunological effects
    K Takada
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Ann Rheum Dis 62:1112-5. 2003
    ..To obtain preliminary information on the safety and efficacy of fludarabine in PsA and analyse its immunomodulatory effects in peripheral blood and synovial tissue...
  73. ncbi Essential role for natural killer cells in the lethal lipopolysaccharide-induced Shwartzman-like reaction in mice
    H Heremans
    Laboratory of Immunobiology, Rega Institute, University of Leuven, Medical School, Belgium
    Eur J Immunol 24:1155-60. 1994
    ..Our data suggest that NK cells may be the most important source of endogenous IFN-gamma which mediates the LPS-induced lethal reactions in mice...
  74. pmc Regulatory T cells promote early influx of CD8+ T cells in the lungs of respiratory syncytial virus-infected mice and diminish immunodominance disparities
    Tracy J Ruckwardt
    Viral Pathogenesis Laboratory, Vaccine Research Center, National Institute of Allergy and Infections Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 83:3019-28. 2009
    ....
  75. pmc Limited ability of humoral immune responses in control of viremia during infection with SIVsmmD215 strain
    Thaidra Gaufin
    Division of Microbiology, Tulane National Primate Research Center, Covington, LA 70433, USA
    Blood 113:4250-61. 2009
    ..Our data suggest that a deficiency of Ab responses did not markedly affect viral replication or disease progression and that they may be compensated by more robust cellular responses...
  76. ncbi Depletion of natural CD4+CD25+ T regulatory cells with anti-CD25 antibody does not change the course of Pseudomonas aeruginosa-induced acute lung infection in mice
    Svetlana O Carrigan
    Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada
    Immunobiology 214:211-22. 2009
    ..These data demonstrate that although P. aeruginosa lung infection causes an increase of Tregs, the endogenous natural CD4+CD25+ Treg cells do not contribute significantly to the host response to this bacterium...
  77. ncbi Rapid TNFR1-dependent lymphocyte depletion in vivo with a selective chemical inhibitor of IKKbeta
    Kumiko Nagashima
    Millennium Pharmaceuticals Inc, 35 Landsdowne St, Cambridge, MA 02139, USA
    Blood 107:4266-73. 2006
    ..This observation has several implications for potential use of IKKbeta inhibitors for the treatment of inflammatory disease and cancer...
  78. pmc Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy
    Michael R Ehrenstein
    Dept of Medicine, Centre for Rheumatology, Windeyer Institute, University College London, London W1T 4JF, England, UK
    J Exp Med 200:277-85. 2004
    ....
  79. pmc Effects of T-lymphocyte depletion on muscle fibrosis in the mdx mouse
    Jamie Morrison
    Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Am J Pathol 166:1701-10. 2005
    ....
  80. pmc Immune failure in the absence of profound CD4+ T-lymphocyte depletion in simian immunodeficiency virus-infected rapid progressor macaques
    Vanessa M Hirsch
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Rockville, Maryland 20852, USA
    J Virol 78:275-84. 2004
    ..The lack of CD4 depletion and loss of humoral and cellular immune responses suggest that their immune defect may be due to an early loss in T helper function...
  81. ncbi Increased expression of the FoxP3 functional marker of regulatory T cells following B cell depletion with rituximab in patients with lupus nephritis
    P P Sfikakis
    First Department of Propedeutic and Internal Medicine, Athens University Medical School, 3, Amaryllidos Str, 15452, Athens, Greece
    Clin Immunol 123:66-73. 2007
    ..Further studies should examine whether modulation of Tregs by therapeutic B cell depletion contributes and/or predicts lupus disease remission...
  82. pmc B cell depletion reduces the development of atherosclerosis in mice
    Hafid Ait-Oufella
    Institut National de la Sante et de la Recherche Medicale INSERM, Unit 970, Paris Cardiovascular Research Center, 75015 Paris, France
    J Exp Med 207:1579-87. 2010
    ..These results challenge the current paradigm that B cell activation plays an overall protective role in atherogenesis and identify new antiatherogenic strategies based on B cell modulation...
  83. pmc Metronomic chemotherapy enhances antitumor effects of cancer vaccine by depleting regulatory T lymphocytes and inhibiting tumor angiogenesis
    Chi An Chen
    Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan
    Mol Ther 18:1233-43. 2010
    ..This provides an immunologic basis for further testing in cancer patients...
  84. ncbi CD8+ T cells are required for primary immunity in C57BL/6 mice following low-dose, intradermal challenge with Leishmania major
    Yasmine Belkaid
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, and Dermatology Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 168:3992-4000. 2002
    ..The low dose, intradermal challenge model reveals that CD8(+) T cells play an essential role in both pathogenesis of and immunity to primary infection with L. major in the skin...
  85. pmc Resolution of secondary Chlamydia trachomatis genital tract infection in immune mice with depletion of both CD4+ and CD8+ T cells
    S G Morrison
    Department of Microbiology, Montana State University, Bozeman, Montana 59717, USA
    Infect Immun 69:2643-9. 2001
    ....
  86. ncbi CD25 is a marker for CD4+ thymocytes that prevent autoimmune diabetes in rats, but peripheral T cells with this function are found in both CD25+ and CD25- subpopulations
    L A Stephens
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    J Immunol 165:3105-10. 2000
    ..Phenotypic analysis of human thymocytes showed the presence of CD25+ cells in the same proportions as in rat thymus. The possible developmental relationship between CD25+ and CD25- regulatory T cells is discussed...
  87. pmc CD4(+)CD25(+) T-cells control autoimmunity in the absence of B-cells
    Eliana Marino
    Immunology and Inflammation Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
    Diabetes 58:1568-77. 2009
    ..We examined the effect of blocking BAFF and APRIL on the development of autoimmune diabetes...
  88. pmc Natural killer cells trigger osteoclastogenesis and bone destruction in arthritis
    Kalle Soderstrom
    Department of Pathology, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Proc Natl Acad Sci U S A 107:13028-33. 2010
    ..These results suggest that NK cells may play an important role in the destruction of bone associated with inflammatory arthritis...
  89. pmc CD8(+)-T-cell depletion ameliorates circulatory shock in Plasmodium berghei-infected mice
    W L Chang
    Department of Medicine, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    Infect Immun 69:7341-8. 2001
    ..berghei malaria, (ii) respiratory distress with lactic acidosis occurs during P. berghei malaria, and (iii) most components of circulatory shock are ameliorated by depletion of CD8(+) T cells...
  90. pmc Apoptosis of uninfected cells induced by HIV envelope glycoproteins
    Barbara Ahr
    Laboratoire Infections Retrovirales et Signalisation Cellulaire, CNRS UMR 5121 UM1, Institut de Biologie, 4, Bd Henri IV, CS 89508, 34960 Montpellier Cedex 2, France
    Retrovirology 1:12. 2004
    ..This review summarizes current knowledge of Env-mediated cell death leading to T cell depletion and clinical complications and covers the sometimes conflicting studies that address the possible mechanisms of T cell death...
  91. pmc Protective immunity against secondary poxvirus infection is dependent on antibody but not on CD4 or CD8 T-cell function
    Vijay Panchanathan
    Infection and Immunology Group, Division of Immunology and Genetics, The John Curtin School of Medical Research, Australian National University, Mills Road, Acton, ACT 0200, Australia
    J Virol 80:6333-8. 2006
    ..Thus, antibody is essential, but CD4 or CD8 T cells are not required for recovery from secondary poxvirus infection...
  92. ncbi B lymphocyte depletion by CD20 monoclonal antibody prevents diabetes in nonobese diabetic mice despite isotype-specific differences in Fc gamma R effector functions
    Yan Xiu
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 180:2863-75. 2008
    ..Moreover, this study defines a new, clinically relevant approach whereby B cell depletion early in the course of disease development may prevent diabetes or delay progression of disease...
  93. pmc Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses
    R P Sutmuller
    Department of Immunohematology and Blood Transfusion, Tumor Immunology Lab, E3-Q, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    J Exp Med 194:823-32. 2001
    ..Simultaneous intervention with both regulatory mechanisms is therefore a promising concept for the induction of therapeutic antitumor immunity...
  94. ncbi Administration of herpes simplex-thymidine kinase-expressing donor T cells with a T-cell-depleted allogeneic marrow graft
    P Tiberghien
    Etablissement Français du Sang, Bourgogne Franche Comté, and Service d Anatomie Pathologique and Service d Hématologie, Centre Hospitolier Universitoire CHU Besançon, Besancon, France
    Blood 97:63-72. 2001
    ..Such findings open the way to the infusion of higher numbers of gene-modified donor T cells to enhance post-BMT immune competence while preserving GCV-sensitive alloreactivity...
  95. ncbi Cytomegalovirus in hematopoietic stem cell transplant recipients: Current status, known challenges, and future strategies
    Michael Boeckh
    University of Washington, Seattle, WA 81009, USA
    Biol Blood Marrow Transplant 9:543-58. 2003
    ....
  96. ncbi Isolation and enrichment of urologic tumor cells in blood samples by a semi-automated CD45 depletion autoMACS protocol
    Axel Meye
    Department of Urology, Faculty of Medicine, Technical University Dresden, Fetscherstrasse 74, D 01307 Dresden, Germany
    Int J Oncol 21:521-30. 2002
    ..The improved sensitivity and specificity might be of importance when applying the protocol to BS in future clinical studies...
  97. pmc Comparative study of brain CD8+ T cells induced by sporozoites and those induced by blood-stage Plasmodium berghei ANKA involved in the development of cerebral malaria
    Sébastien Bagot
    Unité d Immunophysiopathologie Infectieuse, CNRS URA 1961, Universite Pierre et Marie Curie, Paris, France
    Infect Immun 72:2817-26. 2004
    ..These CD8(+) T cells display an activated phenotype, do not undergo apoptosis, secrete gamma interferon or tumor necrosis factor alpha, and are associated with the development of the neurological syndrome...
  98. ncbi CD4+CD25+ T regulatory cells dominate multiple immune evasion mechanisms in early but not late phases of tumor development in a B cell lymphoma model
    Kutlu G Elpek
    Institute for Cellular Therapeutics and Department of Microbiology and Immunology, University of Louisville, Louisville, KY 40202, USA
    J Immunol 178:6840-8. 2007
    ....
  99. pmc Lineage-specific T-cell reconstitution following in vivo CD4+ and CD8+ lymphocyte depletion in nonhuman primates
    Jessica C Engram
    Department of Pathology, University of Pennsylvania, Philadelphia, USA
    Blood 116:748-58. 2010
    ..Here, we performed experiments of in vivo CD4(+) or CD8(+) lymphocyte depletion in 2 nonhuman primate species, rhesus macaques (RMs) and sooty mangabeys (SMs)...
  100. pmc In vivo depletion of CD4(+)CD25(hi) regulatory T cells is associated with improved antiviral responses in cats chronically infected with feline immunodeficiency virus
    S Rochelle Mikkelsen
    College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    Virology 403:163-72. 2010
    ..We propose that short-term in vivo Treg cell depletion during chronic HIV-1 infection could provide a window of opportunity for therapeutic vaccination in individuals with controlled viral replication...
  101. pmc Characterization of molecularly cloned simian-human immunodeficiency viruses causing rapid CD4+ lymphocyte depletion in rhesus monkeys
    G B Karlsson
    Division of Human Retrovirology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Virol 71:4218-25. 1997
    ..6P) inducing rapid CD4+ lymphocyte depletion and AIDS-like illness in rhesus monkeys (K. Reimann, J. T. Li, R. Veazey, M. Halloran, I.-W. Park, G. B...

Research Grants64

  1. The Role of Alcohol in HIV Therapy Hepatotoxicity
    Craig J McClain; Fiscal Year: 2012
    ..provided by applicant): It is clear that alcohol abuse can alter/suppress immune function, including CD4 T-lymphocyte depletion, which can accelerate HIV progression...
  2. Effect of chromatin remodelers/modifiers on HIV-1 Tat activated transcription
    Fatah Kashanchi; Fiscal Year: 2010
    ..AIDS is characterized by CD4+ T lymphocyte depletion. Tat, the viral trans-activator encoded by the HIV-1 genome, is responsible for HIV-1 replication at the ..
  3. ISLET CELL MEMBRANE ANTIBODIES IN DIABETES
    Christiane S Hampe; Fiscal Year: 2013
    ..in T1D has been suggested in animal studies, and the recent Rituximab trial demonstrated that global B lymphocyte depletion has a beneficial effect on the preservation of beta cell function...
  4. T and B cell Homeostasis After Induction Therapy in Kidney Transplantation
    Fadi G Lakkis; Fiscal Year: 2013
    ....
  5. Mechanisms of SIV suppression by CD8+ lymphocytes
    Guido Silvestri; Fiscal Year: 2013
    ..Here we propose to conduct a series of experiments of in vivo CD8+ lymphocyte depletion aimed at better elucidating the antiviral effects of these cells during chronic SIV mac239 infection of RMs...
  6. Regulatory B-cells Limit CNS Inflammation and Infarct in Experimental Stroke
    Halina Offner; Fiscal Year: 2013
    ..The aims of this application are: 1) Determine the effects of B lymphocyte depletion and regulatory B10 cell restoration and treatment on infarct size, immune cellular composition and ..
  7. Mechanisms for SIV evasion of vaccine immunity: Role of FasL-mediated cell death
    CHARLES PAUZA; Fiscal Year: 2009
    ..We believe that FasL, whose expression increases during viral infection, is a principal mediator of lymphocyte depletion, especially within the Fas receptor expressing memory cell population, and may also influence the acute ..
  8. B Cell immunomodulation in islet transplantation
    Ali Naji; Fiscal Year: 2006
    ..Furthermore, our pilot studies in non-human primate recipients suggest that transient B lymphocyte depletion using an anti-CD20 mAb (i.e...
  9. TOPOLOGICAL ANALYSIS OF HIV-1 ENVELOPE GLYCOPROTEINS
    Joseph Sodroski; Fiscal Year: 2004
    ..of a laboratory-adapted HIV-1 isolate, HXBc2, resulted in a virus that caused rapid CD4-positive T-lymphocyte depletion and AIDS in rhesus monkeys. A molecularly cloned virus, SHIV-HXBc2P 3...
  10. gp100 Peptide Immunization after Lymphocyte Depletion
    Walter Urba; Fiscal Year: 2004
    ..Similar results were achieved whether lymphocyte depletion was accomplished with radiation or chemotherapy...
  11. Predictors for drug selection and minimization in pediatric liver transplantation
    Rakesh Sindhi; Fiscal Year: 2009
    ..Pre-LTx lymphocyte depletion permits steroid avoidance and lowers need for Tacrolimus immunosuppression...
  12. Biology and Pathogenesis of Primate Lentiviruses
    Mario Stevenson; Fiscal Year: 2002
    ..In an attempt to establish the underlying basis for lymphocyte depletion in HIV-1 infection, investigators are taking various approaches to evaluate various aspects of the ..
  13. HIV FITNESS, VIRULENCE AND EVOLUTION
    Warner Greene; Fiscal Year: 2003
    ..work, the investigator and his colleagues have been able to study the molecular and cellular aspects of lymphocyte depletion by HIV...
  14. NOVEL IMMUNOTHERAPY FOR HIV
    JAMES LARRICK; Fiscal Year: 2000
    ..the rhesus monkeys had no evidence of lymphocyte dysfunction, lymphocyte depletion or immunosuppression (Reiman et al, 1997)...
  15. THYMUS PATHOPHYSIOLOGY POST-FETAL/NEONATAL FIV INFECTION
    Calvin Johnson; Fiscal Year: 2000
    ..The potential for thymus regeneration to enhance productive infection and to support centralized T-lymphocyte depletion will be determined after the pharmacologic induction of thymus atrophy in conjunction with neonatal FIV ..
  16. Studies of the HIV-associated cell cycle disease
    Guido Silvestri; Fiscal Year: 2006
    ..we have found that CCD is most prominent in vivo in the subset of patients who manifest persistent lymphocyte depletion despite HAART-induced suppression of viral replication...
  17. REPLICATION AND PATHOGENICITY OF HIV/SIV CHIMERAE
    Joseph Sodroski; Fiscal Year: 2004
    Animal models represent essential tools for dissecting the molecular mechanisms of CD4+ T-lymphocyte depletion, a process central to immunopathogenesis in HIV-1-infected humans...
  18. Induction of allograft tolerance in non-human primates
    Anthony Monaco; Fiscal Year: 2006
    ..ALS and rapamycin is an extremely effective immuno-suppressive combination; ALS induces tissue lymphocyte depletion and T cell apoptosis while rapamycin promotes activation-induced T cell apoptosis...
  19. REGULATION OF THYMOPOIESIS IN HIV1 DISEASE
    Laura Napolitano; Fiscal Year: 2003
    ..and intensive chemotherapy are states of profound immune depression marked by peripheral T- lymphocyte depletion and deficiencies in cell-mediated immunity...
  20. RETROVIRAL INFECTION OF THE THYMUS IN AIDS PATHOGENESIS
    Michael Rosenzweig; Fiscal Year: 2000
    DESCRIPTION: (Adapted from investigator's abstract) CD4 lymphocyte depletion associated with HIV infection is a dynamic process, reflecting both the destruction of peripheral T lymphocytes as well as a reduced output of lymphocyte ..
  21. HIV INFECTION IN CHILDREN OF IV DRUG ABUSERS
    Savita Pahwa; Fiscal Year: 1999
    ..synthesis, indicates that this could be a highly significant mechanism for functional unresponsiveness and lymphocyte depletion in HIV infection...
  22. Clinical system for depletion of alloreactive T cells
    James Bender; Fiscal Year: 2001
    ..Recipient monocytes will be enriched by T and B lymphocyte depletion using the automated Isolex magnetic cell separator...
  23. ACETABULAR BONE LOSS AFTER PROSTHETIC HIP ARTHROPLASTY
    R Looney; Fiscal Year: 2005
    ..In addition, DNA and serum samples from all subjects studied in this proposal will be banked. ..
  24. BLys inhibition using TACI-Fc in patients with B-bell non-Hodgkins' Lymphoma
    Stephen Ansell; Fiscal Year: 2008
    ..abstract_text> ..
  25. B CELL SUPERANTIGENS AND IMMUNE REGULATION
    Gregg Silverman; Fiscal Year: 2008
    ..In addition, these studies will lead to a better understanding of the immunobiologic activities of a virulence factor from one of the most important causes of life-threatening infection in the US. ..
  26. Arthritis Research Conference 2007
    Gregg Silverman; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  27. Arthritis Research Conference 2005
    Gregg Silverman; Fiscal Year: 2005
    ..abstract_text> ..
  28. Immune control of SIVagm replication in vivo
    JOERN SCHMITZ; Fiscal Year: 2009
    ..3. Assess whether abolishing both cellular and humoral adaptive immune responses will affect the course of SIVagm infection of African green monkeys. ..
  29. CD8 LYMPHOCYTE RESPONSES IN SIV PATHOGENESIS
    JOERN SCHMITZ; Fiscal Year: 2004
    ..Determine the contribution of CD8+ lymphocytes to the loss of CD4+ Tcells following infection by SIVmac or the rapidly CD4+T cell-depleting virus SHIV-KB9. ..
  30. Cell Death and Antibody-Mediated Protection from Autoimmunity
    GREGG JOSHUA SILVERMAN; Fiscal Year: 2010
    ....
  31. alpha4beta1 Intergrin Signaling In Immunity And Arthritis
    GREGG JOSHUA SILVERMAN; Fiscal Year: 2010
    ..Collectively, this work will provide insight into the role of the ct4-paxillin interaction in inflammation and immunity, and whether this interaction is a potential bona fide therapeutic target for arthritis. ..
  32. Mechanisms to Induce Protective Natural Autoimmunity
    Gregg Silverman; Fiscal Year: 2004
    ..abstract_text> ..
  33. RHEUMATIC DISEASES CORE CENTER
    Gregg Silverman; Fiscal Year: 2006
    ..An Administrative Core (PI-G.J. Silverman, Center Director) will provide overall direction and supervision to all Center programs through an Executive Committee, which will be assisted by an Outside Advisory Committee. ..
  34. Mycophenylate mofetil for treatment of chronic GVHD
    Paul Martin; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  35. Becton Dickinson LSR-II Analytical Cytometer (BD-LSR-II)
    David Serreze; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  36. Identification of Biomarkers in Sjogren's Syndrome
    IGNACIO E SANZ; Fiscal Year: 2010
    ....
  37. The Basis of Functional Variation in Gamma/Delta T cells
    REBECCA O BRIEN; Fiscal Year: 2009
    ..We will also examine the importance to disease outcome of the ability of each subset to produce particular cytokines, induce the death of other cells, and undergo apoptosis. ..
  38. ANTIGEN PRESENTING CELL DEFECTS IN AUTOIMMUNE DIABETES
    David Serreze; Fiscal Year: 2009
    ..Successful completion of our proposed studies might ultimately provide means for preventing the development of this devastating disease. ..
  39. Function & Fate of Alloantigen-specific CD8 Cell in GVHD
    Paul Martin; Fiscal Year: 2005
    ..The studies proposed in this application will help clarify the critical functions and fate of specific donor CD8 cell population that cause GVHD. ..
  40. Campath-1H & Calcineurin-Inhibitors in Renal Transplant
    Stuart Knechtle; Fiscal Year: 2007
    ..abstract_text> ..
  41. A PHASE ll TRIAL OF RITUXAN IN MULTIPLE SCLEROSIS
    DOROTHY CROSS; Fiscal Year: 2007
    ..Parks and Naismith, and PI will be able to focus 30% more time on investigator-initiated trials and mentoring junior colleagues. ..
  42. EFFECTOR MOLECULES IN DEMYELINATING DISEASE
    Anne Cross; Fiscal Year: 2001
    ..Since there now have been identified pharmaceutic agents which can inhibit the production of PN, our findings from these studies may indicate an area with therapeutic potential for MS. ..
  43. TRANSPLANTATION TOLERANCE USING IMMUNOTOXIN
    Stuart Knechtle; Fiscal Year: 2001
    ..The goal of this proposal would be to develop adequate preclinical data to permit phase I and II clinical trials in organ transplant recipients. ..
  44. Renal Transplantation Using Campath1H/Rapamycin
    Stuart Knechtle; Fiscal Year: 2003
    ..This data will be correlated with histopathology of protocol biopsies. ..
  45. TEMPORALLY CONTROLLED DEPLETION OF ALLOREACTIVE T CELLS
    Paul Martin; Fiscal Year: 2002
    ..Results of these preclinical studies will help to assess the potential risks and benefits of using similar approaches to prevent GVHD in human marrow transplantation. ..
  46. THE ROLE OF B CELLS IN EAE PATHOGENESIS
    Anne Cross; Fiscal Year: 2004
    ..Methods to alter in humans the number and function of B cells and Abs already exist, making our results potentially applicable to MS therapy. ..
  47. Body size, physical activity, and Hodgkin's disease risk
    Sally Glaser; Fiscal Year: 2004
    ..abstract_text> ..
  48. Study of Human B-cell Tolerance by Functional Genomics
    Ignacio Sanz; Fiscal Year: 2005
    ..In addition, although the questions asked are hypothesis-driven, the approach proposed is highly exploratory and, as such, is responsive to this RFA. ..
  49. Spontaneous Corneal Inflammation in gd T cell absence
    REBECCA O BRIEN; Fiscal Year: 2005
    ..In addition, we will carryout experiments designed to examine whether the disease is autoimmune, results from bacterial infection, or stems from damage caused by a chemical released from dirty cage litter. ..
  50. B cell functional and signaling abnormalities in SLE
    Jennifer Anolik; Fiscal Year: 2006
    ..abstract_text> ..
  51. A Model System for the Study of Human B-cell Tolerance
    Ignacio Sanz; Fiscal Year: 2007
    ..Furthermore, we believe that our results will improve our ability to treat patients with SLE and similar diseases. [unreadable] [unreadable]..
  52. Composite Tissue Transplantation
    Thomas Tung; Fiscal Year: 2006
    ..The broad objective of this proposal is to improve the quality of reconstructive options and the quality of life for patients with devastating deformities. ..
  53. CXCR3 Chemokine Receptor in Non-Human Primate Allograft
    Stuart Knechtle; Fiscal Year: 2006
    ..We plan to take advantage of the combined experience of the Hancock and Knechtle labs to address the research questions posed herein. ..
  54. U. of Wisconsin Transplant Research Training Program
    Stuart Knechtle; Fiscal Year: 2006
    ....
  55. Identifying Ligands with Soluble Gamma/Delta TCRs
    REBECCA O BRIEN; Fiscal Year: 2006
    ..3 sTCR. The backup approach involves generation of ligand specific mAbs, identified by their ability to block sTCR/ligand binding, as reagents to affinity-purify the ligand. ..
  56. CD22 AND B CELL RECEPTOR INDUCED DEATH
    Edward Clark; Fiscal Year: 2003
    ..This work will provide new insights into how the fate of B lymphocytes is regulated, which may be pertinent to understanding origins of leukemias, lymphomas and autoimmune diseases. ..
  57. IN VITRO/IN VIVO ACTIVATED DENDRITIC CELLS FOR MELANOMA
    Jeffrey Weber; Fiscal Year: 2003
    ....
  58. ADHESION MOLECULES MEDIATING SKIN TROPISM IN ACUTE GVHD
    Robert Sackstein; Fiscal Year: 2003
    ....
  59. ROLE OF NOTCH IN T CELL IMMUNE RESPONSES
    Scott Adler; Fiscal Year: 2003
    ..In Aim 3 antigen presenting cells will be engineered to express Notch ligands to explore the role of physiologic Notch signaling on T cell immune responses. ..
  60. ISLET OF LANGERHANS GRAFT MONITORING BY MAGNETIC RESONANCE IMAGING
    Thierry Berney; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  61. Distinct functional phases in innate reconstitution
    Jeffery Auletta; Fiscal Year: 2008
    ..Sound mentorship and established infrastructure will combine with the applicant's personal commitment in fostering his development into a fully funded independent investigator. ..
  62. Formation and Function of Human CD28-Negative T Cells
    Dorothy Lewis; Fiscal Year: 2004
    ..These studies are important for understanding the biology of human memory T cells especially for vaccine design. ..
  63. T Cell Expansion and Colitis in Immunodeficient Mice
    Charles Surh; Fiscal Year: 2009
    ..Third, cellular mechanisms involved in regulating potentially pathogenic CD4 cells will be better defined. Results from these investigations may be useful in designing better approaches for preventing or treating IBDs in humans. ..
  64. Ex vivo expansion of HER-2/neu specific T helper cells
    Keith Knutson; Fiscal Year: 2008
    ..abstract_text> ..