immunosuppression

Summary

Summary: Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.

Top Publications

  1. ncbi IDO expression by dendritic cells: tolerance and tryptophan catabolism
    Andrew L Mellor
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, Augusta, Georgia 30912, USA
    Nat Rev Immunol 4:762-74. 2004
  2. ncbi Mesenchymal stem cells: a new strategy for immunosuppression and tissue repair
    Yufang Shi
    Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Cell Res 20:510-8. 2010
  3. ncbi State of the art of clinical islet transplantation and novel protocols of immunosuppression
    A M James Shapiro
    Clinical Islet Transplant Program, University of Alberta, Edmonton, AB T6G 2C8, Canada
    Curr Diab Rep 11:345-54. 2011
  4. pmc Persistent inflammation and immunosuppression: a common syndrome and new horizon for surgical intensive care
    Lori F Gentile
    Department of Surgery, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    J Trauma Acute Care Surg 72:1491-501. 2012
  5. ncbi A phase III study of belatacept-based immunosuppression regimens versus cyclosporine in renal transplant recipients (BENEFIT study)
    F Vincenti
    Kidney Transplant Service, University of California San Francisco, San Francisco, CA, USA
    Am J Transplant 10:535-46. 2010
  6. ncbi Effect of HIV-1 and increasing immunosuppression on malaria parasitaemia and clinical episodes in adults in rural Uganda: a cohort study
    J Whitworth
    Medical Research Council Programme on AIDS, Uganda Virus Research Institute, Entebbe
    Lancet 356:1051-6. 2000
  7. pmc HLA-mismatched renal transplantation without maintenance immunosuppression
    Tatsuo Kawai
    Transplantation Unit, Massachusetts General Hospital, and Harvard Medical School, Boston, USA
    N Engl J Med 358:353-61. 2008
  8. ncbi The parallel lives of angiogenesis and immunosuppression: cancer and other tales
    Gregory T Motz
    Ovarian Cancer Research Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Immunol 11:702-11. 2011
  9. pmc Myeloid derived suppressor cells in human diseases
    Tim F Greten
    National Institutes of Health, National Cancer Institute, Medical Oncology Branch, 9000 Rockville Pike, Bethesda MD 20892, USA
    Int Immunopharmacol 11:802-7. 2011
  10. ncbi Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism
    David C Gondek
    Department of Microbiology and Immunology, Dartmouth Medical School and Norris Cotton Cancer Center, Lebanon, NH 03756, USA
    J Immunol 174:1783-6. 2005

Detail Information

Publications312 found, 100 shown here

  1. ncbi IDO expression by dendritic cells: tolerance and tryptophan catabolism
    Andrew L Mellor
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, Augusta, Georgia 30912, USA
    Nat Rev Immunol 4:762-74. 2004
    ..In this review, we summarize key recent developments and propose a unifying model for the role of IDO in tolerance induction...
  2. ncbi Mesenchymal stem cells: a new strategy for immunosuppression and tissue repair
    Yufang Shi
    Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Cell Res 20:510-8. 2010
    ..Our recent studies have shown that un-stimulated MSCs are indeed incapable of immunosuppression; they become potently immunosuppressive upon stimulation with the supernatant of activated lymphocytes, or ..
  3. ncbi State of the art of clinical islet transplantation and novel protocols of immunosuppression
    A M James Shapiro
    Clinical Islet Transplant Program, University of Alberta, Edmonton, AB T6G 2C8, Canada
    Curr Diab Rep 11:345-54. 2011
    ..We review the current status of islet transplantation, and discuss current and future immunosuppressive protocols that will pave the way to more broad application of cellular replacement in diabetes...
  4. pmc Persistent inflammation and immunosuppression: a common syndrome and new horizon for surgical intensive care
    Lori F Gentile
    Department of Surgery, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    J Trauma Acute Care Surg 72:1491-501. 2012
    ..number of patients who survive initial sepsis or surgical events and progress to a persistent inflammation, immunosuppression, and catabolism syndrome (PICS)...
  5. ncbi A phase III study of belatacept-based immunosuppression regimens versus cyclosporine in renal transplant recipients (BENEFIT study)
    F Vincenti
    Kidney Transplant Service, University of California San Francisco, San Francisco, CA, USA
    Am J Transplant 10:535-46. 2010
    ..This Phase III study (Belatacept Evaluation of Nephroprotection and Efficacy as First-line Immunosuppression Trial) assessed a more intensive (MI) or less intensive (LI) regimen of belatacept versus cyclosporine in ..
  6. ncbi Effect of HIV-1 and increasing immunosuppression on malaria parasitaemia and clinical episodes in adults in rural Uganda: a cohort study
    J Whitworth
    Medical Research Council Programme on AIDS, Uganda Virus Research Institute, Entebbe
    Lancet 356:1051-6. 2000
    An association between HIV-1 and malaria is expected in theory, but has not been convincingly shown in practice. We studied the effects of HIV-1 infection and advancing immunosuppression on falciparum parasitaemia and clinical malaria.
  7. pmc HLA-mismatched renal transplantation without maintenance immunosuppression
    Tatsuo Kawai
    Transplantation Unit, Massachusetts General Hospital, and Harvard Medical School, Boston, USA
    N Engl J Med 358:353-61. 2008
    ....
  8. ncbi The parallel lives of angiogenesis and immunosuppression: cancer and other tales
    Gregory T Motz
    Ovarian Cancer Research Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Immunol 11:702-11. 2011
    Emerging evidence indicates that angiogenesis and immunosuppression frequently occur simultaneously in response to diverse stimuli...
  9. pmc Myeloid derived suppressor cells in human diseases
    Tim F Greten
    National Institutes of Health, National Cancer Institute, Medical Oncology Branch, 9000 Rockville Pike, Bethesda MD 20892, USA
    Int Immunopharmacol 11:802-7. 2011
    ..Alternatively, MDSC can be targeted by treatment with the multi-targeted receptor tyrosine kinase inhibitor sunitinib. This review will provide a comprehensive summary of the recent literature on human MDSC...
  10. ncbi Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism
    David C Gondek
    Department of Microbiology and Immunology, Dartmouth Medical School and Norris Cotton Cancer Center, Lebanon, NH 03756, USA
    J Immunol 174:1783-6. 2005
    ..In summary, GZ-B is one of the key mechanisms through which CD4+CD25+ Treg induce cell contact-mediated suppression...
  11. pmc Immunosuppression by mesenchymal stem cells: mechanisms and clinical applications
    Soufiane Ghannam
    INSERM, U844, Montpellier F 34091, France
    Stem Cell Res Ther 1:2. 2010
    ..The present review aims at discussing the current knowledge on the targets and mechanisms of MSC-mediated immunosuppression as well as the potential use of MSCs as modulators of immune responses in a variety of diseases related to ..
  12. pmc Inflammatory cytokine-induced intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in mesenchymal stem cells are critical for immunosuppression
    Guangwen Ren
    Department of Molecular Genetics, Microbiology, and Immunology, Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey, USA
    J Immunol 184:2321-8. 2010
    ..However, we found that ICAM-1 and VCAM-1 were critical for mesenchymal stem cell (MSC)-mediated immunosuppression. When MSCs were cocultured with T cells in the presence of T cell Ag receptor activation, they significantly ..
  13. ncbi Interleukin-10-secreting type 1 regulatory T cells in rodents and humans
    Maria Grazia Roncarolo
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, San Raffaele Scientific Institute, Milan, Italy
    Immunol Rev 212:28-50. 2006
    ....
  14. ncbi CD8+ Foxp3+ regulatory T cells mediate immunosuppression in prostate cancer
    Yukiko Kiniwa
    Department of Pathology, The Center for Cell and Gene Therapy, Baylor Colleg of Medicine, Houston, Texas 77030, USA
    Clin Cancer Res 13:6947-58. 2007
    ..In this study, we investigated prostate tumor-derived CD8(+) Treg cells and their function...
  15. pmc Blockade of T-lymphocyte KCa3.1 and Kv1.3 channels as novel immunosuppression strategy to prevent kidney allograft rejection
    I Grgic
    Department of Internal Medicine and Nephrology, University Hospital, Philipps University, Marburg, Germany
    Transplant Proc 41:2601-6. 2009
    ..Thus, selective blockade of T-lymphocyte K(Ca)3.1 and K(v)1.3 channels may represent a novel alternative therapy for prevention of kidney allograft rejection...
  16. pmc Oncogenic BRAF(V600E) promotes stromal cell-mediated immunosuppression via induction of interleukin-1 in melanoma
    Jahan S Khalili
    Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Clin Cancer Res 18:5329-40. 2012
    ....
  17. pmc Identification of a CD11b(+)/Gr-1(+)/CD31(+) myeloid progenitor capable of activating or suppressing CD8(+) T cells
    V Bronte
    Department of Oncology and Surgical Sciences, Padua University, Padova, Italy
    Blood 96:3838-46. 2000
    ..These cells are responsible for the immunosuppression observed in pathologies as dissimilar as tumor growth and overwhelming infections, or after immunization ..
  18. ncbi Posttransplant lymphoproliferative disorders after renal transplantation in the United States in era of modern immunosuppression
    Sophie Caillard
    Nephrology Service, Walter Reed Army Medical Center, Washington, DC 20307 5001, and Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    Transplantation 80:1233-43. 2005
    ..Posttransplant lymphoproliferative disorders (PTLD) still represent a major preoccupation after renal transplantation, even in the most recent years...
  19. ncbi Incidence of cancers in people with HIV/AIDS compared with immunosuppressed transplant recipients: a meta-analysis
    Andrew E Grulich
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia
    Lancet 370:59-67. 2007
    ..Our aim was to compare cancer incidence in population-based cohort studies of people with HIV/AIDS and people immunosuppressed after solid organ transplantation...
  20. ncbi Antigen-specific inhibition of CD8+ T cell response by immature myeloid cells in cancer is mediated by reactive oxygen species
    Sergei Kusmartsev
    H Lee Moffitt Cancer Center, University of South Florida, 12902 Magnolia Drive, Tampa, FL 33612, USA
    J Immunol 172:989-99. 2004
    ..This study demonstrates a new mechanism of Ag-specific T cell inhibition mediated by ROS produced by ImCs in cancer...
  21. pmc Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes
    David H Munn
    Department of Pediatrics, Institute for Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Clin Invest 114:280-90. 2004
    ..We hypothesize that IDO-mediated suppression by pDCs in TDLNs creates a local microenvironment that is potently suppressive of host antitumor T cell responses...
  22. ncbi Dendritic cell dysfunction in cancer: a mechanism for immunosuppression
    Alberto Pinzon-Charry
    Dendritic Cell and Cancer Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Immunol Cell Biol 83:451-61. 2005
    ....
  23. ncbi Immunosuppression in cardiac graft rejection: a human in vitro model to study the potential use of new immunomodulatory drugs
    Clara Crescioli
    Center for Research Transfer and High Education DENOthe, University of Florence, Florence, Italy
    Exp Cell Res 314:1337-50. 2008
    ..plays a pivotal role in cardiac allograft rejection, so that targeting CXCL10 without inducing generalized immunosuppression may be of therapeutic significance in allotransplantation...
  24. pmc Inhibition of PPARγ in myeloid-lineage cells induces systemic inflammation, immunosuppression, and tumorigenesis
    Lingyan Wu
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202 5188, USA
    Blood 119:115-26. 2012
    ..BM transplantation revealed that a myeloid-autonomous defect was responsible for MDSC expansion, immunosuppression, and tumorigenesis in these mice...
  25. ncbi The consequences of UV-induced immunosuppression for human health
    Mary Norval
    Biomedical Sciences, University of Edinburgh, Edinburgh, Scotland
    Photochem Photobiol 87:965-77. 2011
    ....
  26. ncbi Reducing immunosuppression preserves allograft function in presumptive and definitive polyomavirus-associated nephropathy
    S Schaub
    Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Switzerland
    Am J Transplant 10:2615-23. 2010
    Early detection of polyomavirus BK (BKV) viremia and reduction of immunosuppression is recommended for preventing polyomavirus-associated nephropathy (PyVAN), but systematic histological evaluations were not performed in previous studies...
  27. ncbi Regulatory T-cell as orchestra leader in immunosuppression process of multiple sclerosis
    Farhad Jadidi-Niaragh
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Immunopharmacol Immunotoxicol 33:545-67. 2011
    ..In this review, we intend to submit the comprehensive information about the immunobiology of various subsets of Tregs and their roles and function in immunopathophysiology of MS and its animal model, EAE...
  28. pmc A ferret model of canine distemper virus virulence and immunosuppression
    Veronika von Messling
    Molecular Medicine Program, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Virol 77:12579-91. 2003
    ..Thus, virulence-inducing mutations have accumulated throughout the genome...
  29. ncbi Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration
    Mathias Heikenwalder
    Institute of Neuropathology, University Hospital of Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Nat Med 10:187-92. 2004
    ....
  30. ncbi MRI-visible polymeric vector bearing CD3 single chain antibody for gene delivery to T cells for immunosuppression
    Guihua Chen
    Liver Transplantation Center, The Third Affiliated Hospital, Sun Yat Sen University, Guangzhou 510630, China
    Biomaterials 30:1962-70. 2009
    ..Gene therapy mediated by nonviral vectors provides great advantages over conventional drug therapy in inducing immunosuppression after organ transplantation, yet it was rarely reported because T cells are normally difficult to transfect...
  31. ncbi Methamphetamine enhances histoplasmosis by immunosuppression of the host
    Luis R Martinez
    Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Infect Dis 200:131-41. 2009
    ..b>Immunosuppression by methamphetamine may be associated with deregulation of cytokines in the lungs of infected mice, aberrant ..
  32. ncbi Immunosuppression after traumatic or ischemic CNS damage: it is neuroprotective and illuminates the role of microglial cells
    Nils P Hailer
    Department of Orthopaedics, Institute for Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Prog Neurobiol 84:211-33. 2008
    ..view that microglial cells cause secondary damage have proposed that inhibition of microglial activation by immunosuppression is beneficial after acute CNS damage...
  33. ncbi Immunosuppression affects CD4+ mRNA expression and induces Th2 dominance in the microenvironment of cutaneous squamous cell carcinoma in organ transplant recipients
    Maria Kosmidis
    Department of Dermatology, University Hospital Zurich, Gloriastrasse, Zurich, Switzerland
    J Immunother 33:538-46. 2010
    ..CD4(+) mRNA was diminished in immunosuppression. Skin adjacent to SCC in OTRs showed Th2 expression pattern as compared with immunocompetent patients...
  34. pmc Yersinia V-antigen exploits toll-like receptor 2 and CD14 for interleukin 10-mediated immunosuppression
    Andreas Sing
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat Munchen, Pettenkoferstrasse 9a, Germany
    J Exp Med 196:1017-24. 2002
    ..report that recombinant LcrV signals in a CD14- and toll-like receptor 2 (TLR2)-dependent fashion leading to immunosuppression by interleukin 10 induction...
  35. pmc Liver xeno-repopulation with human hepatocytes in Fah-/-Rag2-/- mice after pharmacological immunosuppression
    Zhiying He
    Department of Cell Biology, Second Military Medical University, Shanghai, China
    Am J Pathol 177:1311-9. 2010
    ..Our new protocol for humanized liver could be applied in the study of human hepatitis virus infection in vivo, as well as the pharmacokinetics and efficacy of potential vaccines...
  36. ncbi Successful treatment of BK viremia using reduction in immunosuppression without antiviral therapy
    Ehab R Saad
    Department of Medicine, Division of Nephrology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Transplantation 85:850-4. 2008
    Treatment of BK virus (BKV) infection in renal transplant recipients remains controversial. This retrospective analysis evaluated efficacy and safety of reducing immunosuppression without antiviral therapy.
  37. ncbi Competition between immune function and lipid transport for the protein apolipophorin III leads to stress-induced immunosuppression in crickets
    S A Adamo
    Department of Psychology, Dalhousie University, Halifax, NS B3H 4J1, Canada
    J Exp Biol 211:531-8. 2008
    Intense physical activity results in transient immunosuppression in a wide range of animals...
  38. pmc The liver is a site for tumor-induced myeloid-derived suppressor cell accumulation and immunosuppression
    Dan Ilkovitch
    Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, Florida 33101, USA
    Cancer Res 69:5514-21. 2009
    Tumor-induced immunosuppression plays a key role in tumor evasion of the immune system. A key cell population recognized as myeloid-derived suppressor cells (MDSC) contributes and helps orchestrate this immunosuppression...
  39. pmc Transplantation-associated long-term immunosuppression promotes oral colonization by potentially opportunistic pathogens without impacting other members of the salivary bacteriome
    Patricia I Diaz
    Division of Periodontology, Department of Oral Health and Diagnostic Sciences, The University of Connecticut Health Center, Farmington, CT, USA
    Clin Vaccine Immunol 20:920-30. 2013
    Solid-organ transplant recipients rely on pharmacological immunosuppression to prevent allograft rejection. The effect of such chronic immunosuppression on the microflora at mucosal surfaces is not known...
  40. ncbi Corticosteroid-free immunosuppression with tacrolimus, mycophenolate mofetil, and daclizumab induction in renal transplantation
    Lionel Rostaing
    Multiorgan Transplant Unit, Rangueil University Hospital, 31059 Toulouse, France
    Transplantation 79:807-14. 2005
    Corticosteroid-free maintenance immunosuppression after organ transplantation eliminates the well-known corticosteroid-related side effects and may help to improve long-term outcome...
  41. pmc Mesenchymal stem cells prevent the rejection of fully allogenic islet grafts by the immunosuppressive activity of matrix metalloproteinase-2 and -9
    Yunchuan Ding
    Transplantation Research Immunology Group, Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Diabetes 58:1797-806. 2009
    ..Mesenchymal stem cells (MSCs) are known to be capable of suppressing immune responses, but the molecular mechanisms involved and the therapeutic potential of MSCs remain to be clarified...
  42. ncbi Corticosteroid-free immunosuppression in liver transplantation: a meta-analysis and meta-regression of outcomes
    George Sgourakis
    Second Surgical Department, Red Cross Hospital, Athens, Greece
    Transpl Int 22:892-905. 2009
    To examine the impact of steroid withdrawal from the immunosuppression protocols in liver transplantation. The electronic databases Medline, Embase, Pubmed and the Cochrane Library were searched...
  43. pmc Role of immunosuppression and tumor differentiation in predicting recurrence after liver transplantation for hepatocellular carcinoma: a multicenter study of 412 patients
    Thomas Decaens
    Service d hépatologie et de gastroentérologie, AP HP, Hopital Henri Mondor, Creteil, Unite INSERM 581, France
    World J Gastroenterol 12:7319-25. 2006
    ....
  44. ncbi Allergic airway inflammation inhibits pulmonary antibacterial host defense
    Christoph Beisswenger
    Department of Internal Medicine, Division for Pulmonary Diseases, Philipps Universitat Marburg, Germany
    J Immunol 177:1833-7. 2006
    ..These results show that an allergic airway inflammation suppresses the innate antimicrobial host defense. The adaptive immune system modulates the functions of the pulmonary innate immune system...
  45. pmc Risk factors for early-onset and late-onset post-transplant lymphoproliferative disorder in kidney recipients in the United States
    Scott C Quinlan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA
    Am J Hematol 86:206-9. 2011
    Solid-organ transplant recipients have an elevated risk for some malignancies because of the requirement for immunosuppression [1]...
  46. pmc Impaired lymphatic contraction associated with immunosuppression
    Shan Liao
    EL Steele Laboratory, Department of Radiation Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 108:18784-9. 2011
    ..Our unique method allows the study of lymphatic function and its molecular regulation during inflammation, lymphedema, and lymphatic metastasis...
  47. ncbi Sirolimus-based immunosuppression is associated with increased survival after liver transplantation for hepatocellular carcinoma
    Christian Toso
    Section of Hepatobiliary, Pancreatic and Transplant Surgery, University of Alberta, Edmonton, Canada
    Hepatology 51:1237-43. 2010
    ..with the use of sirolimus and a higher one with calcineurin inhibitors, but the selection of an ideal immunosuppression protocol is still a matter of debate...
  48. pmc Cigarette smoke extract suppresses the RIG-I-initiated innate immune response to influenza virus in the human lung
    Wenxin Wu
    Pulmonary and Critical Care Division, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, USA
    Am J Physiol Lung Cell Mol Physiol 300:L821-30. 2011
    ..This immunosuppressive effect of CSE may play a role in the enhanced susceptibility of smokers to serious influenza infection in the lung...
  49. ncbi Complete immunosuppression withdrawal and subsequent allograft function among pediatric recipients of parental living donor liver transplants
    Sandy Feng
    Division of Transplantation, Department of Surgery, University of California, San Francisco, CA 94143, USA
    JAMA 307:283-93. 2012
    Although life-saving, liver transplantation burdens children with lifelong immunosuppression and substantial potential for morbidity and mortality.
  50. ncbi Reversal of gastrointestinal carcinoma-induced immunosuppression and induction of antitumoural immunity by a combination of cyclophosphamide and gene transfer of IL-12
    Mariana Malvicini
    Gene Therapy Laboratory, Liver Unit, School of Medicine, Austral University, Derqui Pilar, Buenos Aires, Argentina
    Mol Oncol 5:242-55. 2011
    ..The results of this study support the hypothesis that Cy + AdIL-12 might be a valid immunotherapeutic strategy for advanced GIC...
  51. ncbi Immunotherapy for the adjunctive treatment of sepsis: from immunosuppression to immunostimulation. Time for a paradigm change?
    Jenneke Leentjens
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Am J Respir Crit Care Med 187:1287-93. 2013
    ..In addition, we present an appraisal of the recent advances in immunotherapy as an adjunctive treatment for sepsis...
  52. ncbi Managing the risks of immunosuppression
    D Sean Riminton
    Department of Immunology, Concord Hospital, Concord, Sydney, New South Wales, Australia
    Curr Opin Neurol 24:217-23. 2011
    ..We review recent data on immunosuppression in diverse settings to guide the assessment and prevention of adverse effects from these therapies with the ..
  53. pmc IFN-γ-induced iNOS expression in mouse regulatory macrophages prolongs allograft survival in fully immunocompetent recipients
    Paloma Riquelme
    Department of Surgery, Laboratory for Transplantation Research, University Hospital Regensburg, Regensburg, Germany
    Mol Ther 21:409-22. 2013
    ..Clinical applications of M reg therapy as an adjunct immunosuppressive therapy are currently being investigated within The ONE Study...
  54. ncbi Myeloid suppressor lines inhibit T cell responses by an NO-dependent mechanism
    Alessandra Mazzoni
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 Department of Oncology and Surgical Sciences, Oncology Section, Azienda Ospedaliera, Padova, Italy
    J Immunol 168:689-95. 2002
    ..The distinctive capacity of MSC to generate suppressive signals when encountering activated T cells defines a specialized subset of myeloid cells that most likely serve a regulatory function during times of heightened immune activity...
  55. ncbi A cell-based approach to the minimization of immunosuppression in renal transplantation
    James A Hutchinson
    Laboratory of Transplantation Research of the Clinic of General and Thoracic Surgery, University of Schleswig Holstein, Kiel, Germany
    Transpl Int 21:742-54. 2008
    ..patients received anti-thymocyte globulin induction therapy in combination with tacrolimus and steroid immunosuppression. Over the course of 12 weeks, steroids were withdrawn and tacrolimus therapy was minimized...
  56. ncbi Corticosteroid-free immunosuppression with daclizumab in HCV(+) liver transplant recipients: 1-year interim results of the HCV-3 study
    Goran B G Klintmalm
    Transplantation Services, Baylor University Medical Center, Dallas, TX 75246, USA
    Liver Transpl 13:1521-31. 2007
    ..analysis of a prospective, randomized, multicenter trial evaluating the effect of corticosteroid-free immunosuppression on hepatitis C virus-positive (HCV(+)) liver transplant recipients following liver transplantation (LT)...
  57. pmc TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells
    Julien C Marie
    Department of Immunology, University of Washington, Seattle, WA 98195, USA
    J Exp Med 201:1061-7. 2005
    ..Thus, our results establish an essential link between TGF-beta1 signaling in peripheral T reg cells and T reg cell maintenance in vivo...
  58. ncbi High-dose immunoablation with autologous haematopoietic stem cell transplantation in aggressive multiple sclerosis: a single centre 10-year experience
    Eva Krasulova
    Department of Neurology, Charles University in Prague, 1st Faculty of Medicine and General Teaching Hospital, Prague, Czech Republic
    Mult Scler 16:685-93. 2010
    ..There was no death within 100 days after ASCT. We conclude that ASCT represents a viable and effective treatment option for aggressive multiple sclerosis...
  59. ncbi High mobility group box-1 protein regulate immunosuppression of regulatory T cells through toll-like receptor 4
    Xiao Mei Zhu
    Department of Microbiology and Immunology, Burns Institute, First Hospital Affiliated to the Chinese PLA General Hospital, Beijing 100048, People s Republic of China
    Cytokine 54:296-304. 2011
    ..The present study was performed to clarify effects of HMGB1 on regulatory T cells (Tregs) and the involvement of toll-like receptor (TLR) 4 signaling...
  60. ncbi The osmolyte taurine protects against ultraviolet B radiation-induced immunosuppression
    Nicole Rockel
    Institut fur umweltmedizinische Forschung IUF an der Heinrich Heine Universitat Dusseldorf gGmbH, Dusseldorf, Germany
    J Immunol 179:3604-12. 2007
    ..model, lack of taurine in the skin was found to cause a significantly higher sensitivity to UVB-induced immunosuppression. This was not due to an increased generation or decreased repair of UVB-induced DNA photoproducts in the ..
  61. pmc Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection
    Scott N Mueller
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 104:15430-5. 2007
    Many chronic viral infections are marked by pathogen persistence and a generalized immunosuppression. The exact mechanisms by which this occurs are still unknown...
  62. ncbi Gender differences in UV-induced inflammation and immunosuppression in mice reveal male unresponsiveness to UVA radiation
    Vivienne E Reeve
    Faculty of Veterinary Science, University of Sydney, NSW 2006, Australia
    Photochem Photobiol Sci 11:173-9. 2012
    b>Immunosuppression attributed mainly to the UVB (290-320 nm) waveband is a prerequisite for skin cancer development in mice and humans...
  63. ncbi Long-term survival of limb allografts induced by pharmacologically conditioned, donor alloantigen-pulsed dendritic cells without maintenance immunosuppression
    Ryosuke Ikeguchi
    Department of Surgery, Division of Plastic and Reconstructive Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Transplantation 85:237-46. 2008
    ..Since indefinite graft survival was not achieved, we have further modified the DC by pharmacologic (rapamycin; Rapa) conditioning and ascertained their influence on graft survival, without continued immunosuppressive therapy...
  64. ncbi Autologous stem cell transplantation as rescue therapy in malignant forms of multiple sclerosis
    Giovanni Luigi Mancardi
    Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Genoa, Italy
    Mult Scler 11:367-71. 2005
    ..Recently, it has been demonstrated that intense immunosuppression followed by autologous stem cell transplantation (ASCT) can affect the clinical course of individuals with ..
  65. pmc Hypoxia-driven immunosuppression: a new reason to use thermal therapy in the treatment of cancer?
    Chen Ting Lee
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Int J Hyperthermia 26:232-46. 2010
    ....
  66. ncbi Face transplantation: outcomes, concerns, controversies, and future directions
    Maria Siemionow
    Dermatology and Plastic Surgery Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Craniofac Surg 23:254-9. 2012
    ..Since 2005, 17 facial allotransplantations have been performed worldwide. The brief summary of current cases with ongoing concerns is presented in this article...
  67. ncbi Immunosuppression and the risk of post-transplant malignancy among cadaveric first kidney transplant recipients
    Rami T Bustami
    Scientific Registry of Transplant Recipients University Renal Research and Education Association, Ann Arbor, MI, USA
    Am J Transplant 4:87-93. 2004
    The success of renal transplantation may be counterbalanced by serious adverse medical events. The effect of immunosuppression on the incidence of de novo neoplasms among kidney recipients should be monitored continuously...
  68. ncbi CD4+CD25+ regulatory T cells control the severity of viral immunoinflammatory lesions
    Susmit Suvas
    Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA
    J Immunol 172:4123-32. 2004
    ..Our results decipher the in vivo role of T(reg) in a virus-induced immunopathology and imply that manipulation of regulatory cell function represents a useful approach to control viral-induced immunoinflammatory disease...
  69. ncbi Mesenchymal stem cells prevent acute rejection and prolong graft function in pancreatic islet transplantation
    Biancamaria Longoni
    Department of Oncology, Transplantation and Advanced Technology in Medicine, University of Pisa, Pisa, Italy
    Diabetes Technol Ther 12:435-46. 2010
    ..Mesenchymal stem cells (MSCs) have recently been reported to modulate the immune response in allogeneic transplantation...
  70. ncbi Induction of chimerism in rhesus macaques through stem cell transplant and costimulation blockade-based immunosuppression
    L S Kean
    The Emory Transplant Center, Department of Surgery, Emory University School of Medicine, Atlanta, Georgia, USA
    Am J Transplant 7:320-35. 2007
    ..Nevertheless, this chimerism-induction regimen induced amongst the longest-lived stem cell chimerism reported to date for non-human primates and thus represents a platform upon which to evaluate emerging tolerance-induction strategies...
  71. pmc Identification of a B cell signature associated with renal transplant tolerance in humans
    Kenneth A Newell
    Emory University, Atlanta, Georgia, USA
    J Clin Invest 120:1836-47. 2010
    Establishing long-term allograft acceptance without the requirement for continuous immunosuppression, a condition known as allograft tolerance, is a highly desirable therapeutic goal in solid organ transplantation...
  72. ncbi Alginate macroencapsulation of pig islets allows correction of streptozotocin-induced diabetes in primates up to 6 months without immunosuppression
    Denis Dufrane
    Laboratory of Experimental Surgery, Universite Catholique de Louvain, Faculte de Medecine, Brussels, Belgium
    Transplantation 90:1054-62. 2010
    ..This study assessed the capacity of alginate-encapsulated islets to reverse diabetes in a pig-to-primate model...
  73. pmc Tolerogenic dendritic cells and their role in transplantation
    Mohamed Ezzelarab
    Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, 200 Lothrop Street, BST W1540, Pittsburgh, PA 15261, USA
    Semin Immunol 23:252-63. 2011
    ..Evaluation of technical and therapeutic logistic issues is an important next step prior to the application of tolerogenic DC in clinical organ transplantation...
  74. pmc Short-term immunosuppression promotes engraftment of embryonic and induced pluripotent stem cells
    Jeremy I Pearl
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell Stem Cell 8:309-17. 2011
    ....
  75. ncbi Autoantibody response to islet transplantation in type 1 diabetes
    E Bosi
    Medicine and Surgery, San Raffaele Hospital Scientific Institute, Milan, Italy
    Diabetes 50:2464-71. 2001
    ..transplantation in 36 patients (33 receiving islet plus kidney grafts with cyclosporin and steroid-based immunosuppression, and 3 receiving solitary islet transplants with mycophenolate but cyclosporin-free immunosuppression) ..
  76. pmc Successful attenuation of humoral immunity to viral capsid and transgenic protein following AAV-mediated gene transfer with a non-depleting CD4 antibody and cyclosporine
    J H McIntosh
    Department of Haematology, UCL Cancer Institute, University College London, Oxford, UK
    Gene Ther 19:78-85. 2012
    The ability of transient immunosuppression with a combination of a non-depleting anti-CD4 (NDCD4) antibody and cyclosporine (CyA) to abrogate immune reactivity to both adeno-associated viral vector (AAV) and its transgene product was ..
  77. ncbi Induction of tolerance by exosomes and short-term immunosuppression in a fully MHC-mismatched rat cardiac allograft model
    H Peche
    Institut National de la Santé et de la Recherche Médicale INSERM Unit 643 and Institut de Transplantation et de Recherche en Transplantation ITERT, Nantes, Cedex 1 France
    Am J Transplant 6:1541-50. 2006
    ..These results suggest that under LF treatment, presentation of donor-MHC antigens (from exosomes) can induce regulatory responses that are able to modulate allograft rejection and to induce donor-specific allograft tolerance...
  78. pmc Candida glabrata persistence in mice does not depend on host immunosuppression and is unaffected by fungal amino acid auxotrophy
    I D Jacobsen
    Department for Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, 07745 Jena, Germany
    Infect Immun 78:1066-77. 2010
    ..Notably, our work indicates that C. glabrata has successfully developed immune evasion strategies enabling it to survive, disseminate, and persist within mammalian hosts...
  79. ncbi A high-capacity quantitative mouse model of drug-mediated immunosuppression based on rejection of an allogeneic subcutaneous tumor
    D Hammond-McKibben
    Transplantation Research, Novartis Pharmaceuticals, Summit, New Jersey, USA
    J Pharmacol Exp Ther 297:1144-51. 2001
    We describe a high-capacity in vivo assay to measure drug-mediated transplant immunosuppression using a mouse model of Sa1 tumor rejection. Sa1 grew poorly and was rejected by 14 days in immunocompetent allogeneic recipient mice...
  80. pmc Effects of transient immunosuppression on adenoassociated, virus-mediated, liver-directed gene transfer in rhesus macaques and implications for human gene therapy
    Haiyan Jiang
    Bayer HealthCare Pharmaceuticals, 800 Dwight Way, Berkeley, CA 94710, USA
    Blood 108:3321-8. 2006
    ..Because the vector is incapable of synthesizing viral proteins, a short course of immunosuppression, until AAV capsid is cleared from the transduced cells, may mitigate the host T-cell response, allowing long-..
  81. ncbi Elevated portal vein drug levels of sirolimus and tacrolimus in islet transplant recipients: local immunosuppression or islet toxicity?
    Niraj M Desai
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Transplantation 76:1623-5. 2003
    ..transplantation using the Edmonton protocol involved the use of sirolimus, tacrolimus, and daclizumab for immunosuppression. Islets were infused into the portal circulation after transhepatic access...
  82. pmc Reduced frequency of FOXP3+ CD4+CD25+ regulatory T cells in patients with chronic graft-versus-host disease
    Emmanuel Zorn
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    Blood 106:2903-11. 2005
    ..These findings support the development of new strategies to increase the number of Tregs following allogeneic hematopoietic stem cell transplantation to prevent or correct cGVHD...
  83. ncbi Role of Toll-like receptors in lung innate defense against invasive aspergillosis. Distinct impact in immunocompetent and immunocompromized hosts
    Michel Chignard
    Institut Pasteur, Unité de Défense Innée et Inflammation, Paris, France INSERM, U874, Paris, France
    Clin Immunol 124:238-43. 2007
    ..Moreover, the literature clearly indicates that the type of immunosuppression is very important, as it influences whether or not Toll-like receptors contribute to infection...
  84. ncbi Invasive aspergillosis in allogeneic stem cell transplant recipients: changes in epidemiology and risk factors
    Kieren A Marr
    Fred Hutchinson Cancer Research Center Programs in Infectious Diseases and Long term Follow up, Seattle, WA 98109, USA
    Blood 100:4358-66. 2002
    ....
  85. pmc Ex vivo-expanded human regulatory T cells prevent the rejection of skin allografts in a humanized mouse model
    Fadi Issa
    Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Transplantation 90:1321-7. 2010
    ..transplantation effectively reconstructs the most complex defects, but its use is limited because of harmful immunosuppression and the high susceptibility of skin to rejection...
  86. ncbi Immune suppression in the tumor microenvironment
    Thomas F Gajewski
    Department of Pathology and Department of Medicine University of Chicago, Chicago, IL 60637, USA
    J Immunother 29:233-40. 2006
    ....
  87. pmc Identification of nitric oxide synthase as a protective locus against tuberculosis
    J D MacMicking
    Beatrice and Samuel A Seaver Laboratory, Department of Medicine, Cornell University Medical College, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 94:5243-8. 1997
    ..Progression of chronic tuberculosis in wild-type mice was accelerated by specifically inhibiting NOS2 via administration of N6-(1-iminoethyl)-L-lysine. Together these findings identify NOS2 as a critical host gene for tuberculostasis...
  88. pmc Tacrolimus versus ciclosporin as primary immunosuppression for kidney transplant recipients: meta-analysis and meta-regression of randomised trial data
    Angela C Webster
    Cochrane Renal Group, Centre for Kidney Research, Children s Hospital at Westmead, Westmead, NSW 2145, Australia
    BMJ 331:810. 2005
    ..To compare the positive and negative effects of tacrolimus and ciclosporin as initial treatment for renal transplant recipients...
  89. ncbi Peritoneal macrophage and blood monocyte functions after open and laparoscopic-assisted cecectomy in rats
    S W Lee
    Division of Colon and Rectal Surgery, New York Presbyterian Hospital, Cornell Weill University, New York, NY 10021, USA
    Surg Endosc 17:1996-2002. 2003
    It has been well established that open abdominal surgery results in systemic immunosuppression postoperatively; in contrast, laparoscopic surgery is associated with significantly better preserved systemic immune function...
  90. ncbi Immunosuppression by retroviruses: implications for xenotransplantation
    J Denner
    Paul Ehrlich Institut, Langen, Germany
    Ann N Y Acad Sci 862:75-86. 1998
    Retroviruses induce in the infected host an immunosuppression the severity of which depends on the viral load...
  91. ncbi Induction of a regulatory T cell type 1 response reduces the development of atherosclerosis in apolipoprotein E-knockout mice
    Ziad Mallat
    Institut National de la Sante et de la Recherche Medicale, INSERM U541, Institut Fédératif de Recherche Circulation Paris VII, Hopital Lariboisiere, Paris, France
    Circulation 108:1232-7. 2003
    ....
  92. ncbi Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells
    Katarina Le Blanc
    Division of Clinical Immunology and Centre for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Lancet 363:1439-41. 2004
    ..Clinical response was striking. The patient is now well after 1 year. We postulate that mesenchymal stem cells have a potent immunosuppressive effect in vivo...
  93. ncbi Protective effects of diallyl sulfide on N-nitrosodimethylamine-induced immunosuppression in mice
    H G Jeong
    Department of Biological Science, Chosun University, Kwangju, South Korea
    Cancer Lett 134:73-9. 1998
    ..In this study, we investigated the protective effect of DAS on the N-nitrosodimethylamine (NDMA)-induced immunosuppression of humoral and cellular responses in BALB/c mice and the possible mechanisms involved in this protection...
  94. ncbi Nonmelanoma skin cancer after renal transplantation: a single-center experience in 1736 transplantations
    George Zavos
    Transplantation Unit, Laiko General Hospital, Athens, Greece
    Int J Dermatol 50:1496-500. 2011
    Renal transplantation is associated with an increased incidence of nonmela-noma skin cancer (NMSC) caused by immunosuppression. Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), the two major histological types of NMSC, ..
  95. ncbi Dexamethasone-induced immunosuppression: a rabbit model
    Edita Jeklova
    Department of Immunology, Veterinary Research Institute, Hudcova 70, 621 00 Brno, Czech Republic
    Vet Immunol Immunopathol 122:231-40. 2008
    Rabbits are often used as animal models for experimental purposes; in many cases steroid-induced immunosuppression is necessary...
  96. ncbi Polyclonal rabbit antithymocyte globulin exhibits consistent immunosuppressive capabilities beyond cell depletion
    Gina Lacorcia
    Transplant and Immunology Research, Genzyme Corporation, Framingham, MA 01701, USA
    Transplantation 87:966-74. 2009
    ..However, nondepleting mechanisms may also be important mediators of graft survival. In the present study, 14 lots of thymoglobulin (rabbit ATG) were analyzed and compared for nondepletive immunomodulatory activities in vitro...
  97. ncbi Kidney transplantation: the ideal immunosuppression regimen
    Julie M Yabu
    Department of Medicine, Division of Nephrology, Stanford University Medical Center, Palo Alto, CA 94304, USA
    Adv Chronic Kidney Dis 16:226-33. 2009
    ..The emergence of new immunosuppressive agents and tolerance protocols appear promising as a means to deliver immunosuppression without long-term toxicity...
  98. ncbi Regulatory T cells as modulators of chronic allograft dysfunction
    Fadi Issa
    Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, United Kingdom
    Curr Opin Immunol 23:648-54. 2011
    ..The pathogenesis of CAD is largely secondary to chronic damage by the adaptive immune system and long-term immunosuppression. Manipulating these factors may be possible with the use of regulatory T cells (Treg), which have the ..
  99. ncbi Human anergic/suppressive CD4(+)CD25(+) T cells: a highly differentiated and apoptosis-prone population
    L S Taams
    Department of Clinical Immunology, Royal Free and University College Medical School, London, GB
    Eur J Immunol 31:1122-31. 2001
    ..Further studies into their role in normal and pathological situations in humans are clearly essential...
  100. pmc Canine distemper viruses expressing a hemagglutinin without N-glycans lose virulence but retain immunosuppression
    Bevan Sawatsky
    INRS Institut Armand Frappier, University of Quebec, Laval, Quebec H7V 1B7, Canada
    J Virol 84:2753-61. 2010
    ..expressing N-glycan-deficient H proteins no longer caused disease, even though their immunosuppressive capacities were retained, indicating that reduced N glycosylation contributes to attenuation without affecting immunosuppression.
  101. pmc BK-virus and the impact of pre-emptive immunosuppression reduction: 5-year results
    K L Hardinger
    Department of Pharmacy Practice, University of Missouri Kansas City, Kansas City, MO, USA
    Am J Transplant 10:407-15. 2010
    A 1-year, single-center, randomized trial demonstrated that the calcineurin inhibitor or adjuvant immunosuppression, independently, does not affect BK-viruria or viremia and that monitoring and pre-emptive withdrawal of immunosuppression ..

Research Grants120 found, 100 shown here

  1. Antiphospholipid antibodies and lupus: new molecular targets for treatment
    Emilio B Gonzalez; Fiscal Year: 2013
    ..These studies may help to devise new more specific and less harmful modalities than the anticoagulation or general immunosuppression currently used to treat and prevent thrombosis in patients with aPL Abs.
  2. Non-viral Genetic Modification of Antigen-presenting Cells in Allografts
    Wilson S Meng; Fiscal Year: 2011
    ..rationale for testing ex vivo IL-10 gene therapy in transplantation of DC-rich organs to achieve specific immunosuppression. PUBLIC HEALTH RELEVANCE: This project emphasizes the development of an ex vivo gene therapy approach to ..
  3. Immunomodulatory and regenerative effects of mesenchymal stem cells on allografts
    Norma S Kenyon; Fiscal Year: 2013
    ..However, broader application to the cure of type 1 diabetes has been limited by the requirement for chronic immunosuppression and the scarcity of organ donors...
  4. Targeting iNOS to inhibit myeloid-derived suppressor cells (MDSC) in melanoma
    ANDREW GREGORY SIKORA; Fiscal Year: 2013
    ..will significantly enhance our understanding of the relationship between inflammation and tumor-mediated immunosuppression, and provide a sound platform for establishing an independent research career in cancer immunology and ..
  5. Chemokine Decoy Receptor for Therapy of Autoimmune Arthritis
    Kanneganti Murthy; Fiscal Year: 2012
    ..arthritis ("RA") (corticosteroids, methotrexate, neutralization of TNF-?) rely upon broad-spectrum immunosuppression, an approach that is not uniformly effective and is frequently associated with significant side-effects...
  6. Neonatal Chemoselection Following Ex Vivo Gene Transfer For Hereditary Disorders
    KARIN L GAENSLER; Fiscal Year: 2012
    ..hematopoietic stem cells (HSC), the toxicity of necessary preparative regimens and post-transplant immunosuppression, and graft vs. host disease (GVHD)...
  7. CTL response to AAV Vector
    Richard J Samulski; Fiscal Year: 2013
    ..e. without immunosuppression addendums)...
  8. MIF AND THE HOST RESPONSE TO INFECTION
    RICHARD J BUCALA; Fiscal Year: 2013
    ..We defined MIF's ability to override glucocorticoid immunosuppression, induce sustained activation of the ERK1/2 MAP kinase, and inhibit activation-induced, monocyte/macrophage ..
  9. Deriving hepatocytes from disease specific iPS to treat metabolic liver disorders
    Namita Roy-Chowdhury; Fiscal Year: 2013
    ..this promising therapeutic modality are the scarcity of high quality donor organs and the need for prolonged immunosuppression to prevent allograft rejection...
  10. Bone Marrow Transplantation for Hematologic Malignancies using Novel Radioimmunot
    John M Pagel; Fiscal Year: 2013
    ..the demonstration of the ability of such an approach to: 1) ablate the marrow space, and 2) produce adequate immunosuppression. Thus, in aim 3 we will also evaluate the kinetics and durability of hematopoietic and immune cell ..
  11. Inflammation and Immunosuppression in Lung Cancer
    Cong Yan; Fiscal Year: 2013
    ..Indeed, ablation of the lal gene resulted in systemic increase of MDSCs and immunosuppression of T cell proliferation/function in LAL knockout (lal-/-) mice...
  12. Chemokine Decoy Receptor: a novel therapy of IBD
    Kanneganti Murthy; Fiscal Year: 2012
    ..approaches to Crohn's Disease (corticosteroids, neutralization of TNF-?) rely upon broad-spectrum immunosuppression, an approach that is not uniformly effective and is frequently associated with major side-effects...
  13. White matter changes in HIV models
    Pamela E Knapp; Fiscal Year: 2011
    ..Highly active, or combined, antiretroviral therapy (HAART or cART) has controlled viral replication and immunosuppression, and initially reduced the severity of neurologic disease...
  14. Non-Hodgkin lymphoma in women: reproductive, hormonal and genetic factors
    Paige M Bracci; Fiscal Year: 2011
    ..in men than in women and few risk factors have been established other than those associated with severe immunosuppression and some rare genetic conditions...
  15. COCHLEAR MACROPHAGES AND EPITHELIAL REPAIR
    Keiko Hirose; Fiscal Year: 2013
    ..the role of leukocytes in the inner ear after hair cell injury and will allow us to begin understanding how immunosuppression affects normal processes as well as pathological processes in the inner ear...
  16. HIFU-enhanced tumor vaccines
    Chandan Guha; Fiscal Year: 2012
    ..Furthermore, novel chemotherapeutic agents that suppress STAT3-mediated immunosuppression will be combined to examine whether inhibiting immunosuppressive pathways in tumor can augment the HIFU-..
  17. Bacterial Immunosuppression: Host Target Identification Through Chemical Probes
    Kim D Janda; Fiscal Year: 2013
    ..should provide great insight into a biochemical understanding of AHL-mediated mechanisms of bacterial immunosuppression and lead to the identification of new members of the pattern recognition receptor family...
  18. Virus interference with Toll like Receptor Response on Dendritic Cells
    Elina I Zuniga; Fiscal Year: 2010
    ..For instance, virus infections such as HIV or Measles are associated with immunosuppression and enhanced susceptibility to opportunistic infections, resulting in millions of death worldwide...
  19. Developing a New Therapeutic for the Treatment of Invasive Aspergillosis
    Mitchell W Mutz; Fiscal Year: 2013
    ..However, inhibition of HC causes severe immunosuppression and toxicity...
  20. Mac-1 (CR3) and Fc gamma receptors in immune-mediated neutrophil cytotoxicity
    Tanya N Mayadas; Fiscal Year: 2013
    ..have demonstrated marked therapeutic efficacy in autoimmune diseases, but also exhibited potentially fatal immunosuppression. In this application we propose to delineate signaling pathways that potentially promote microvascular ..
  21. Targeting Sirtuin-1 to enhance Foxp3+ regulatory T-cell function
    Ulf Beier; Fiscal Year: 2013
    ..Likewise, therapies for autoimmune diseases and organ transplantation face the challenge of achieving enough immunosuppression to prevent organ rejection or limit autoreactivity without impairing the host's ability to protect ..
  22. A Protein Biologic for the Treatment of Sepsis
    Rafal M Smigrodzki; Fiscal Year: 2010
    ..a reversible suppression of mitochondrial complex I, ATP production and oxygen consumption which result in immunosuppression and widespread organ failure...
  23. Genetic Epidemiology of Life-Threatening Influenza in Children
    Adrienne G Randolph; Fiscal Year: 2013
    ..Our preliminary data revealed that both cytokine storm and innate immunosuppression are associated with mortality in children with influenza infection...
  24. Vaccine Immunotoxin and Radioimmunotherapy of Primary and Metastatic CNS Tumors
    Darell D Bigner; Fiscal Year: 2013
    ..Project 2, led by John Sampson, and is entitled, "Targeting Immunosuppression Pathways to Enhance Brain Tumor Immunotherapy...
  25. Endothelial microparticles in patients with kidney transplants
    Sergey Brodsky; Fiscal Year: 2012
    ..With improved immunosuppression and surgical technique, graft survival has significantly increased...
  26. GRAFT REJECTION AND DIRECT VERSUS INDIRECT RECOGNITION
    PETER SCOTT HEEGER; Fiscal Year: 2013
    ..rejection, donor deficiency of complement component C3 or factor D (fD) synergizes with sub-therapeutic immunosuppression to markedly prolong allograft survival, and C3a receptor/C5a receptor double knockout T cells do no reject ..
  27. Innate and Adaptive Immune Mechanisms in Arthritis
    RICHARD J BUCALA; Fiscal Year: 2013
    ..is protective in experimental arthritis and we reported on MIF's ability to override glucocorticoid immunosuppression, induce sustained activation of ERK1/2 MAP kinases, and promote inflammation by inhibiting activation-..
  28. Epigenetic Control of T cell Autoimmunity
    Daniel L Mueller; Fiscal Year: 2010
    ..autoimmune diseases such as rheumatoid arthritis (RA) currently relies on the use of intense generalized immunosuppression, thus increasing the risk of infection and malignancy...
  29. Immunosuppression by Adult Stem Cells
    Yufang Shi; Fiscal Year: 2013
    ..in suppressing T cells and have a similar spectrum of chemokine production, they utilize IDO to affect immunosuppression. Thus, we hypothesize that proinflammatory cytokines induce MSCs to produce chemokines and NO (in mouse) or ..
  30. Acute Humoral Rejection of Renal Allografts
    Robert L Fairchild; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Current Immunosuppression has decreased the incidence of acute cellular rejection of renal allografts...
  31. Analyzing the Efficacy of Galectin-1 Ligand Inhibition in Adoptive T cell Therapy
    JENNA GEDDES SWEENEY; Fiscal Year: 2012
    ..on helper T cells has led to the hypothesis that Gal-1 elicits tumor-immune escape mechanisms by inducing immunosuppression on melanoma antigen-specific CD8+ T cells...
  32. Ursodeoxycholic Acid Therapy in Pediatric Primary Sclerosing CholangitisA pilot
    Benjamin L Shneider; Fiscal Year: 2012
    ..Biochemical control of childhood PSC with histologic features of AIH is dependent upon treatment with immunosuppression in addition to UDCA, therefore childhood PSC without histologic features of AIH will worsen significantly ..
  33. VIRAL INFECTION INFLUENCE ON TRANSPLANTATION TOLERANCE
    DALE LESLIE GREINER; Fiscal Year: 2013
    ..induction protocols have brought us closer to achieving allograft survival in the absence of chronic immunosuppression. However, virus infection poses a threat to the allotolerant state because it can disrupt immunoregulation ..
  34. HTS platform for identification of regulators of cell adhesion molecule signaling
    Darren G Woodside; Fiscal Year: 2013
    ..therapeutics has proven invaluable in the treatment of patients but is limited by side-effects related to immunosuppression and the induction of autoimmune reactions...
  35. Molecular Mechanisms of Rapamycin's effects on Health and longevity.
    Joseph A Baur; Fiscal Year: 2013
    ..Unfortunately, side effects including immunosuppression and the elevation of cardiovascular risk factors are likely to limit the utility of the drug in humans...
  36. Hematopoietic gene therapy for hemophilia A
    H Trent Spencer; Fiscal Year: 2013
    ..of BDDpfVIII-transduced HSCs following low-toxicity pre-transplantation conditioning with targeted immunosuppression, even in the context of pre-existing anti-human fVIII inhibitors...
  37. Role of innate immunity and injury in transplant-induced reactivation of MCMV
    Michael M Abecassis; Fiscal Year: 2013
    ..of reactivation in this model is similar to that observed in transplant recipients treated with standard immunosuppression protocols...
  38. Generation and Evaluation of KSHV VLPs as Vaccines
    GARY S contact HAYWARD; Fiscal Year: 2010
    ..uncommon, except in AIDS-patients with promiscuous life-style factors, where this combined with HIV-induced immunosuppression produces KS at high frequency...
  39. Neuropeptides and Regulatory T cells
    Doina Ganea; Fiscal Year: 2013
    ..Effective therapies should address both early and late stages, avoid generalized immunosuppression, and have local rather than systemic effects...
  40. Vitamin D Inhibition of HIV and M. Tuberculosis Coinfection in Macrophages
    Stephen A Spector; Fiscal Year: 2010
    ..Treatment of Mtb in the presence of HIV/AIDS is complicated by the immunosuppression associated with HIV infection and the pharmacologic interactions between drugs used for treatment of both ..
  41. Angiogenesis and Long-term Bone and Joint Allotransplant Survival
    Allen T Bishop; Fiscal Year: 2012
    ..Maintaining allogeneic tissue viability without immunosuppression would be an important advance, and is the goal of this grant renewal proposal...
  42. Functional impact of dendritic cell phenotype in a mouse model of myositis
    Dana P Ascherman; Fiscal Year: 2010
    ..The latter objective is relevant to the treatment of multiple autoimmune diseases for which global immunosuppression is the only therapeutic option.
  43. Phase 2 Study of Abatacept with Calcineurin Inhibition and Methotrexate for GVHD
    Leslie S Kean; Fiscal Year: 2013
    ..Importantl, the risks of aGVHD and infection are reciprocal: while potent immunosuppression can decrease the risk of aGVHD, it results in an increased risk of infection due to the attendant defects in ..
  44. Assay Development for Inhibitors of KSHV
    Paul M Lieberman; Fiscal Year: 2010
    ..KSHV-associated disease is significantly elevated in the context of HIV-AIDS, as well as in other forms of immunosuppression, including organ and bone-marrow transplant...
  45. Lentivirus-based positive/negative selection in minimally ablative transplants
    KARIN L GAENSLER; Fiscal Year: 2013
    ..the only treatment for many genetic disorders, is limited by the lack of donors, toxicity of conditioning/immunosuppression, and graft vs. host disease (GVHD)...
  46. Investigation of synergy between Rifampin and SQ109, a new anti-TB drug candidate
    VENKATA REDDY; Fiscal Year: 2009
    ..tuberculosis-infected individuals becomes even less in the setting of secondary immunosuppression caused by HIV and malnutrition, conditions that are rampant in developing countries...
  47. Estrogen and Immunoprotection in Experimental Stroke
    Patricia D Hurn; Fiscal Year: 2013
    ..lymphocytes that have a regulatory phenotype (CD4+CD25+FoxP3+ Treg cells) and ordinarily provide endogenous immunosuppression. Subsequently, there is a progressive apoptosis of the spleen, with broad destruction of most constituent ..
  48. EMBRYONIC STEM CELLS INDUCE SPECIFIC GRAFT TOLERANCE
    Nicholas Zavazava; Fiscal Year: 2012
    ..be used to induce mixed chimerism across major histocompatibility barriers with minimal requirement for immunosuppression. Here, we will utilize the homeodomain transcription factor HOXB4 that confers self-renewal and expansion ..
  49. Role of macrophages in pancreatic islet graft rejection
    Midhat H Abdulreda; Fiscal Year: 2013
    ..of transplanted islets and will minimize/prevent devastating systemic side effects associated with chronic immunosuppression. These findings will have implications in transplantation therapies in general, as well as in cancer and ..
  50. Predicting the burden of renal disease among liver transplant recipients
    Pratima Sharma; Fiscal Year: 2013
    ..liver transplant (LT) recipients have the second highest incidence of post-LT CRF despite the lower level of immunosuppression by calcineurin inhibitors, compared to heart and lung transplant recipients...
  51. Functional immuno-imaging of lymphocyte motility and cell interactions in lymph n
    Michael D Cahalan; Fiscal Year: 2013
    ..Tregs) interfere with naive T cell activation, and how ion channels in T cells can be targeted for in vivo immunosuppression. Studies will be based on 2P imaging of human and murine immune cells in experimental models of the immune ..
  52. Delayed Tolerance Induction in Living Related Donor Renal Transplant Recipients
    Suzanne T Ildstad; Fiscal Year: 2012
    ..Three subjects have been off all immunosuppression for 10 months, 2 months, and 1 month respectively and have remained chimeric with stable renal function...
  53. Engineered tumor-specific T cells Resist Hypoxic-Tumor Immunosuppressive Attacks.
    Patricia Yotnda; Fiscal Year: 2013
    ..2) H2O2 induced immunosuppression can be overcome by overexpressing antioxidant proteins in T cells...
  54. PERIPHERAL NEUROPATHY IN LENTIVIRUS INFECTIONS: EARLY VIRAL AND HOST DETERMINANTS
    Christopher Power; Fiscal Year: 2010
    ..Lentiviruses including HIV-1 and feline immunodeficiency virus (FIV) cause immunosuppression and neurological disease defined by the development of DSP...
  55. Activation of rapamycin-sensitive TORC1 by endomembrane amino acid transporters
    MARIA E CARDENAS-CORONA; Fiscal Year: 2013
    ..Based on its potent antiproliferative activity, rapamycin is in use in several clinical areas including immunosuppression, cancer chemotherapy, and interventional cardiology...
  56. Hepatocyte - Based Therapies of Primary Hyperoxaluria 1
    Namita Roy Chowdhury; Fiscal Year: 2010
    ..Also, transplantation of allogeneic hepatocytes requires immunosuppression to prevent graft rejection...
  57. Regulation of miRNA expression during helper T cell differentiation
    KARL MARK ANSEL; Fiscal Year: 2010
    ..of the molecular control of T cell responses, and may lead to novel strategies for immunomodulation or immunosuppression. PUBLIC HEALTH RELEVANCE: Helper T cells are the central coordinators of immune responses...
  58. Identification of Immune modulators associated with JC virus replication
    Jennifer Gordon; Fiscal Year: 2013
    ..It is believed that immunosuppression with potent new classes of immunosuppressive agents, including the anti-CD20 molecule, rituximab, allows JC ..
  59. Immunoregulation of Myelin Specific T Lymphocytes
    Arthur A Vandenbark; Fiscal Year: 2013
    ..acetate), but have greatly increased toxicity and risk of serious life- threatening infections due to global immunosuppression. A preferred treatment approach would be a safe and well-tolerated biologic with a potent ability to inhibit ..
  60. Bioprocess for cardiac cell generation from human induced pluripotent stem cells
    EMMANOUHL TZANAKAKIS; Fiscal Year: 2013
    ..is severely limited due to the scarcity of organ donors and complications associated with the required immunosuppression. Cell therapies aiming at replacing infracted heart muscle are highly desirable...
  61. Malaria treatment outcomes and pharmacokinetics in HIV-infected pregnant women
    MYAING MYAING NYUNT; Fiscal Year: 2010
    ..nevirapine), drug resistance, and acquired immunity (which may be modified by pregnancy- and HIV-related immunosuppression) in the treatment outcomes...
  62. The geriatric surgical patient: stress, anesthetics, and functional outcomes
    Stacie Deiner; Fiscal Year: 2012
    ..general anesthesia with TIVA will have less stress, induction of the oxidative damage response, and immunosuppression than patients who receive inhalational anesthesia...
  63. KSHV Lytic DNA Replication and its Control Mechanism
    Subhash C Verma; Fiscal Year: 2013
    ..This study is important because the incidence of immunosuppression is still a concern due to HIV infection and the use of immunosuppressive drugs in organ transplant/..
  64. Immune-based nutrient deprivation and neurodegenerative disease
    Carol Anne Colton; Fiscal Year: 2013
    ..b>Immunosuppression is a feature of acquired immune privilege that protects critical cells but reduces the ability of the tissue ..
  65. The role of Nox2 in CNI-induced renal fibrosis
    Arjang Djamali; Fiscal Year: 2013
    ....
  66. An Integrative Systems Genetics Approach to Nephrotic Syndrome
    MATTHEW GORDON SAMPSON; Fiscal Year: 2013
    ..Morbidity also results from side effects of nonspecific immunosuppression medications used to treat this disease...
  67. Renal and Cardiovascular Events in Patients with Chronic Kidney Disease
    Akinlolu O Ojo; Fiscal Year: 2013
    ..a) The Chronic Renal Insufficiency Cohort Study (CRIC);and (b) The Sirolimus-based, Steroid Avoidance Immunosuppression in Black de novo Kidney Transplant Recipients...
  68. IDO-silencing Salmonella therapy for the treatment of primary and metastatic PDAC
    Don J Diamond; Fiscal Year: 2013
    ..Current IDO inhibitors inadequately reverse immunosuppression while systemic off target effects contribute to their toxicity...
  69. EGFRvIII-targeted Bispecific T cell Engagers for brain tumors
    John H Sampson; Fiscal Year: 2013
    ..BBB) and accumulate in intracerebral tumors, and (3) may potentially overcome multiple mechanisms of immunosuppression present in patients with GBM...
  70. Interactions of smoking, PD-1 and IL-10 in HIV-associated lung disease
    Brent E Palmer; Fiscal Year: 2013
    ..consequences of increased IL-10 secretion from AMs, a dysfunctional T cell phenotype and HIV-1-induced immunosuppression combine to predispose the HIV-1-infected lung to infection and injury, thereby hastening the development of ..
  71. Effect of Chronic Alcohol on Liver APC and Ag-Specific T-Cells
    KATHERINE BREMPELIS; Fiscal Year: 2013
    ..Both chronic alcohol consumption and liver infection can lead to immunosuppression;however the interaction between the two is not well defined...
  72. Preserving Renal Function &Protective Immunity Via Anti-LFA1-Based CNI Avoidance
    Kenneth A Newell; Fiscal Year: 2013
    ..Our Collaborative will investigate efalizumab as an alternative to CNI-based immunosuppression (IS) in kidney and liver transplantation...
  73. Opioid selection and the risk of serious infections in older adults
    Carlos G Grijalva; Fiscal Year: 2013
    ..g. codeine) reduces immunosuppression, and substitution of a carbonyl group at C6 (e.g. hydromorphone) eliminates the immunosuppressive effects...
  74. Bioengineered siRNA/Nanoparticles to Prevent Human Transplant Rejection
    George Tellides; Fiscal Year: 2013
    ..Rejection remains an important cause of graft loss and current regimens of host immunosuppression produce significant complications...
  75. Human tissue-engineered blood vessels using induced pluripotent stem cells
    Yibing Qyang; Fiscal Year: 2013
    ..the rat model since other preferred large animals (dog or pig) might reject the human tissue even with immunosuppression due to a significant xenogenic response...
  76. JC Virus Primary Infection, Latency, and Reactivation
    CHEN SABRINA TAN; Fiscal Year: 2013
    ..In the context of immunosuppression, JCV can reactivate, causing a demyelinaing diseae of the brain called progressive multifocal ..
  77. Homeostasis and function of regulatory T cells in aging
    David A Hildeman; Fiscal Year: 2013
    ..Although Treg likely contribute to immunosuppression with age, the mechanisms underlying Treg accumulation in the elderly remain unclear...
  78. Adaptive immunity against Pneumocystis
    Chad Steele; Fiscal Year: 2013
    ..epidemic, yet this atypical fungal pathogen is becoming increasingly associated with pharmacologic-driven immunosuppression as well as patients with chronic lung diseases such as COPD...
  79. Novel indication for myeloid progenitor use: Induction of tolerance
    Timothy C Fong; Fiscal Year: 2013
    ..donor-specific immunological tolerance (DSIT), a condition in which a recipient accepts a transplant without immunosuppression, while retaining the ability to fight infections, would reduce graft loss...
  80. Novel Immunotherapeutic Approaches and Tools Utilizing Allogeneic T Cells
    HEATHER JILL SYMONS; Fiscal Year: 2013
    ..alloSCT after nonmyeloablative conditioning and to eliminate the requirement for prolonged pharmacologic immunosuppression after HLA-matched alloSCT...
  81. Novel Costimulation Blockers in Islet Transplantation
    Scott M Krummey; Fiscal Year: 2013
    ..independence by five years post transplantation, most likely as a result of insufficient and/or toxic immunosuppression. Current immunosuppressive agents, in particular calcineurin inhibitors (CNIs), induce significant renal ..
  82. Proteogenomics for Organ Transplantation: Prediction, Diagnosis, Intervention
    Michael M Abecassis; Fiscal Year: 2013
    ..There is a pressing medical need for a minimally invasive, objective metric of optimal immunosuppression to monitor therapy and insure long-term success...
  83. Intracellular oxygen sensing using 19F MRI
    Eric T Ahrens; Fiscal Year: 2013
    ..will test the hypothesis that macrophages localized at sites of inflammation will respond to pharmacological immunosuppression by altering intracellular pO2 levels...
  84. DC-ASGPR AS A NOVEL TARGET FOR CONTROLLING GVHD AND ALLOGRAFT REJECTION
    SangKon Oh; Fiscal Year: 2013
    ..However, immunosuppression does not guarantee the prevention of alloreaction over time in patients who receive organs, tissues, and ..
  85. Adult-to-Adult Living Donor Liver Transplantation Study Data Coordinating Center
    Robert M Merion; Fiscal Year: 2013
    ..determination of long-term LDLT donor outcomes, including health-related quality of life, 2) protocols for immunosuppression minimization in the LDLT setting, 3) continued focus on hepatitis C and hepatocellular carcinoma, 4) ..
  86. CEST/FLEX MRI for the Detection of the Host Immune Response to CNS Grafts
    Miroslaw Janowski; Fiscal Year: 2013
    ..techniques for the detection of the molecular signature of graft rejection and to monitor the effects of immunosuppression on graft infiltration with regard to behavioral outcomes and post mortem analysis of graft differentiation ..
  87. Novel serological biomarkers for BBB dysfunction during HIV-1 infection
    SERVIO HEYBERT RAMIREZ; Fiscal Year: 2013
    ..combined antiretroviral therapy (cART) has provided effective suppression of virus replication, prevented immunosuppression and increased lifespan...
  88. Cytokine regulation of JC virus latency and reactivation
    Martyn K White; Fiscal Year: 2013
    ..However, in the context of severe immunosuppression, especially HIV-1/AIDS, JCV becomes reactivated leadings to PML...
  89. Novel Pathogen Associated Cancers (PQ12)
    David Wang; Fiscal Year: 2013
    ..and there are other cancers that likely have a viral etiology because they too are increased following immunosuppression. Lymphoma, anogenital malignancies and lung cancer have been found to be increasingly common in a diverse ..
  90. NLRP1 activation induces deletion of hematopoietic progenitor cells
    BEN ADAM CROKER; Fiscal Year: 2013
    ..activation of NLRP1 in hematopoietic progenitor cells during infection can induce cytopenia resulting in immunosuppression. We also propose that (2) one of the physiological roles of NLRP1 is to induce Caspase-1-dependent death of ..
  91. Asymptomatic Cryptococcal Antigenemia in HIV-Infected Patients in the United Stat
    Michele W Tang; Fiscal Year: 2013
    ..cryptococcal infection, and use CrAg titers to monitor disease activity and quantify disease burden with immunosuppression and subsequent restoration of immune function...
  92. "Donor-Specific Regulatory T Cell Therapy in Liver Transplantation"
    Qizhi Tang; Fiscal Year: 2013
    ..However, the maintenance of the transplanted liver requires continuous immunosuppression to prevent rejection by the host immune system...
  93. Mayo Clinic SPORE in Ovarian Cancer
    Scott H Kaufmann; Fiscal Year: 2013
    ..Project 2, "Mechanisms of immunosuppression in ovarian cancer," our population sciences project, studies the components of microenvironmental ..
  94. Novel Therapies to Improve Renal and Cardiac Allograft Outcomes
    Anil Chandraker; Fiscal Year: 2013
    ..trial where 300 primary heart transplant recipients with a PRA of <10% will be randomized to conventional immunosuppression (tacrolimus, MMF and rapid steroid taper) versus induction therapy with anti-CD20 mAb (Rituxan) plus ..
  95. Suppression of the Immune Response in Spaceflight and Aging
    Millie Hughes-Fulford; Fiscal Year: 2013
    ..is that [unreadable]g regulates MiRNA in human T-cells and that weightlessness is a novel model to study the immunosuppression seen in aging...
  96. Targeting EGFRvIII in Brain Tumors with Bispecific Antibodies
    Bryan Choi; Fiscal Year: 2013
    ..the BBB and accumulate in intracerebral tumors, and (3) may potentially overcome multiple mechanisms of immunosuppression present in patients with GBM...
  97. Using FAP to Selectively Target Epithelial Cancers
    William W Bachovchin; Fiscal Year: 2013
    ..For instance, is FAP proteolytic activity involved in immunosuppression by FAP+ TAFs? Is FAP proteolytic activity involved in tumor promotion by non- immune effects? Indeed, it is ..
  98. Adult to Adult Living Donor Liver Transplantation
    Robert A Fisher; Fiscal Year: 2013
    ..marker of progression and recurrence of HCC, treatment protocols to prevent HCV recurrence, minimization of immunosuppression, the mechanism of hepatic regeneration and quality of life have the potential to answer fundamental ..
  99. Autoimmune Encephalomyelitis And Regulatory T Cells
    Youhai H Chen; Fiscal Year: 2013
    ..called regulatory T (Treg) cells that are used precisely by the immune system to perform antigen-specific immunosuppression. They play indispensable roles in maintaining health since their deficiency in mice and humans causes fatal ..
  100. Molecular and cellular mechanisms of Merkel Cell Carcinoma development
    Julien Sage; Fiscal Year: 2013
    ..The exact cause of MCC is still unclear, but its development may be linked to sun exposure and immunosuppression. MCC development also correlates very strongly with infection by MCPyV (Merkel Cell PolyomaVirus), a virus ..
  101. A Multidisciplinary and Translational Approach to Hepatobiliary Malignancy
    David R Nelson; Fiscal Year: 2013
    ..cleaved from T and NK cells on activation) and because recent evidence has suggested a role in tumor related immunosuppression. In this application, we will address the hypothesis that Tregs and CD25 are increased in peripheral blood ..