Genomes and Genes
immunologic cytotoxicity tests
Summary: The demonstration of the cytotoxic effect on a target cell of a lymphocyte, a mediator released by a sensitized lymphocyte, an antibody, or complement.
Publications213 found, 100 shown here
- A role for IFN-gamma in primary and secondary immunity generated by NK cell-sensitive tumor-expressing CD80 in vivoJanice M Kelly
Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Institute, East Melbourne, Victoria, Australia
J Immunol 168:4472-9. 2002..Our findings demonstrate a key role for IFN-gamma in innate and adaptive immunity triggered by CD80 expression on tumor cells...
- Distinct role of lymphocyte function-associated antigen-1 in mediating effective cytolytic activity by cytotoxic T lymphocytesNadia Anikeeva
Department of Microbiology and Immunology and Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA
Proc Natl Acad Sci U S A 102:6437-42. 2005..These data provide evidence that LFA-1 delivers a distinct signal essential for directing released cytolytic granules to the surface of antigen-bearing target cells to mediate the effective destruction of these cells by CTL...
- A direct role for NKG2D/MICA interaction in villous atrophy during celiac diseaseSophie Hue
Equipe Avenir Inserm, Hopital Necker Enfants Malades, 75015 Paris, France
Immunity 21:367-77. 2004..This supports a key role for MIC/NKG2D in the activation of intraepithelial immunity in response to danger...
- Final steps of natural killer cell maturation: a model for type 1-type 2 differentiation?M J Loza
Kimmel Cancer Center, Jefferson Medical College, Department of Microbiology and Immunology, Philadelphia, PA, USA
Nat Immunol 2:917-24. 2001..We propose that the cytokine environment regulates a type 2-->0-->1 developmental progression, with IL-12 needed for terminal differentiation and IL-4 delaying this process, rather than a type 1 versus type 2 decision of a type 0 cell...
- Innate direct anticancer effector function of human immature dendritic cells. I. Involvement of an apoptosis-inducing pathwayBratislav M Janjic
University of Pittsburgh Cancer Institute, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15231, USA
J Immunol 168:1823-30. 2002..Overall, our data demonstrate that human immature DCs are capable of inducing apoptosis in cancer cells and thus to both directly mediate anticancer activity and initiate processing of cellular tumor Ags...
- Immature CD4- CD103+ rat dendritic cells induce rapid caspase-independent apoptosis-like cell death in various tumor and nontumor cells and phagocytose their victimsBenjamin Trinité
Institut National de la Santé et de la Recherche Médicale Unité 643, Institut de Transplantation et de Recherche en Transplantation, Nantes University Hospital, Nantes, France
J Immunol 175:2408-17. 2005..Taken together, these data indicate that rat immature CD4- CD103+ DC mediate an unusual cytotoxic activity and can use this function to efficiently acquire Ag from live cells...
- LFA-1 contributes an early signal for NK cell cytotoxicityDomingo F Barber
Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
J Immunol 173:3653-9. 2004..Thus, in contrast to T cells, in which even adhesion through LFA-1 is dependent on signals from other receptors, NK cells receive early activation signals directly through LFA-1...
- Perforin and interferon-gamma activities independently control tumor initiation, growth, and metastasisS E Street
Cancer Immunology, Peter MacCallum Cancer Institute, Victoria, Australia
Blood 97:192-7. 2001....
- NK cell activation by dendritic cells is dependent on LFA-1-mediated induction of calcium-calmodulin kinase II: inhibition by HIV-1 Tat C-terminal domainAlessandro Poggi
Laboratory of Immunology, National Institute for Cancer Research, Genoa, Italy
J Immunol 168:95-101. 2002..These data provide evidence that exogenous Tat inhibits NK cell activation occurring upon contact with DC: this mechanism might contribute to the impairment of natural immunity in HIV-1 infection...
- Cutting edge: rapid in vivo killing by memory CD8 T cellsDaniel L Barber
Emory Vaccine Center and Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA
J Immunol 171:27-31. 2003..These data indicate that virus specific memory CD8 T cells can rapidly acquire cytotoxic function upon re-exposure to Ag and are much more efficient killers in vivo than previously appreciated...
- Vav1 dephosphorylation by the tyrosine phosphatase SHP-1 as a mechanism for inhibition of cellular cytotoxicityChristopher C Stebbins
Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
Mol Cell Biol 23:6291-9. 2003..Such a mechanism explains how inhibitory receptors can block activating signals induced by different receptors...
- Cutting edge: rapid in vivo CTL activity by polyoma virus-specific effector and memory CD8+ T cellsAnthony M Byers
Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA
J Immunol 171:17-21. 2003..These findings strongly support the concept that a cytotoxic effector-memory CD8(+) T cell population operates in vivo to control this persistent viral infection...
- Multiple HLA class II-restricted melanocyte differentiation antigens are recognized by tumor-infiltrating lymphocytes from a patient with melanomaPaul F Robbins
Surgery Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 2B42, Bethesda, MD 20892 7502, USA
J Immunol 169:6036-47. 2002..These observations provide an impetus to develop strategies directed toward generating HLA class II-restricted tumor-reactive T cells...
- Recognition of vaccinia virus-infected cells by human natural killer cells depends on natural cytotoxicity receptorsSusan E Chisholm
Division of Immunology, Department of Pathology, University of Cambridge, UK
J Virol 80:2225-33. 2006..The more general implications of these data for the processes of innate immune recognition are discussed...
- The fluorolysis assay, a highly sensitive method for measuring the cytolytic activity of T cells at very low numbersNorbert Kienzle
The Queensland Institute of Medical Research and the Cooperative Research Centre for Vaccine Technology, University of Queensland, Brisbane QLD 4029, Australia
J Immunol Methods 267:99-108. 2002....
- Beyond 51Cr release: New methods for assessing HIV-1-specific CD8+ T cell responses in peripheral blood and mucosal tissuesB L Shacklett
Gladstone Institute of Virology and Immunology, University of California San Francisco, 94103, USA
Clin Exp Immunol 130:172-82. 2002..This review focuses on recent developments in the assessment of HIV-1-specific T cell responses in peripheral blood and tissues, with a particular emphasis on flow cytometry-based approaches...
- A Structural basis for the association of DAP12 with mouse, but not human, NKG2DDavid B Rosen
Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, CA 94143, USA
J Immunol 173:2470-8. 2004..Further, we show that human NKG2D is incapable of associating with DAP12 and provide evidence that structural differences in the transmembrane of mouse and human NKG2D account for the species-specific difference for this immune receptor...
- SV40 Immortalization of feline fibroblasts as targets for MHC-restricted cytotoxic T-cell assaysS Koksoy
Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Rd, Columbus, OH 43210, USA
Vet Immunol Immunopathol 79:285-95. 2001....
- Fluorescent antigen-transfected target cell cytotoxic T lymphocyte assay for ex vivo detection of antigen-specific cell-mediated cytotoxicityCarel A van Baalen
Department of Virology, Erasmus MC, University Medical Center and Postgraduate School of Molecular Medicine, Rotterdam, The Netherlands
J Infect Dis 192:1183-90. 2005..The FATT-CTL assay provides a versatile tool that will advance our understanding of cell-mediated immunity...
- FL-CTL assay: fluorolysometric determination of cell-mediated cytotoxicity using green fluorescent protein and red fluorescent protein expressing target cellsKong Chen
Louisiana State University Health Sciences Center, Gene Therapy Program, Department of Genetics and Medicine, 533 Bolivar Street, New Orleans, LA 70112, USA
J Immunol Methods 300:100-14. 2005..Thus, this FL-CTL assay is highly sensitive, reliable, reproducible, economical, convenience and supports broad applications compared to conventional CTL assays...
- Expression of the interleukin-21 gene in murine colon carcinoma cells generates systemic immunity in the inoculated hostsShin ichi Ugai
Department of Pathology, Chiba Cancer Centre Research Institute, Japan
Cancer Gene Ther 10:187-92. 2003..Spleen cells from Colon 26/IL-21-tumor- but not parent-tumor-bearing mice had lytic activity to YAC-1 cells. These data suggest that expression of IL-21 in tumors induces T- and NK-cell-dependent antitumor effects...
- Induction of natural killer cell responses by ectromelia virus controls infectionApril Keim Parker
Department of Molecular Microbiology and Immunology, Saint Louis University Health Sciences Center, 1402 South Grand Blvd, St Louis, MO 63104, USA
J Virol 81:4070-9. 2007..These results confirm a crucial role for NK cells in controlling an ECTV infection...
- Cutting edge: predetermined avidity of human CD8 T cells expanded on calibrated MHC/anti-CD28-coated microspheresSteffen Walter
Department of Immunology, Institute for Cell Biology, Division of Hematology and Oncology, University of Tubingen, Tubingen, Germany
J Immunol 171:4974-8. 2003..We believe that the possibility to raise Ag-specific T cells with predetermined avidity will be crucial for the future use of aAPCs in immunotherapeutical settings...
- A ligand for the murine NK activation receptor Ly-49D: activation of tolerized NK cells from beta 2-microglobulin-deficient miceHiroshi Furukawa
Howard Hughes Medical Institute, Rheumatology Division, Barnes Jewish Hospital and Washington University School of Medicine, St Louis, MO 63110 1093, USA
J Immunol 169:126-36. 2002....
- Induction of polyclonal prostate cancer-specific CTL using dendritic cells transfected with amplified tumor RNAA Heiser
Department of Surgery, Division of Urology, Duke University Medical Center, Durham, NC 27710, USA
J Immunol 166:2953-60. 2001....
- Innate direct anticancer effector function of human immature dendritic cells. II. Role of TNF, lymphotoxin-alpha(1)beta(2), Fas ligand, and TNF-related apoptosis-inducing ligandGanwei Lu
University of Pittsburgh Cancer Institute, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15231, USA
J Immunol 168:1831-9. 2002..Overall, our data demonstrate that DCs are fully equipped for an efficient direct apoptotic killing of cancer cells and suggest that this mechanism may play a critical role in both afferent and efferent anti-tumor immunity...
- CD40-activated human B cells: an alternative source of highly efficient antigen presenting cells to generate autologous antigen-specific T cells for adoptive immunotherapyJ L Schultze
Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Invest 100:2757-65. 1997..We, therefore, contend that CD40-activated B cells are an alternative source of highly efficient APCs with which to generate antigen-specific T cells ex vivo for autologous adoptive immunotherapy...
- Interleukin-21 activates cytotoxic T lymphocytes and natural killer cells to generate antitumor response in mouse renal cell carcinomaMasafumi Kumano
Division of Urology, Kobe University Graduate School of Medicine, Kobe, Japan
J Urol 178:1504-9. 2007..We evaluated the antitumor effects of IL-21 gene transfer into mouse RenCa renal cell carcinoma cells, so that cells could spontaneously secrete IL-21. We also investigated the mechanisms underlying this antitumor effect...
- A sensitive flow cytometry-based cytotoxic T-lymphocyte assay through detection of cleaved caspase 3 in target cellsLiwei He
Immunology Platform, Aventis Pasteur Research and Development, Connaught Campus Toronto, Ontario, Canada M2R 3T4
J Immunol Methods 304:43-59. 2005....
- The gp49B1 inhibitory receptor regulates the IFN-gamma responses of T cells and NK cellsXiaogang Gu
Center for Blood Research and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
J Immunol 170:4095-101. 2003..We conclude that gp49B1 is a unique inhibitory receptor that is induced in multiple lineages of innate and adaptive immune cells during an infection and controls their IFN-gamma, but not cytotoxic responses...
- Tolerance induction by veto CTLs in the TCR transgenic 2C mouse model. I. Relative reactivity of different veto cellsShlomit Reich-Zeliger
Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
J Immunol 173:6654-9. 2004..The latter cells as well as nonactivated CD4(+) or NK cells were shown to be completely devoid of veto activity...
- Selective induction of high avidity CTL by altering the balance of signals from APCSangKon Oh
Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 170:2523-30. 2003..Our data also suggested that dendritic cells play an important role in induction of high avidity CD8(+) CTL in vivo. This strategy to selectively induce higher avidity CTL may lead to more effective vaccines for viruses and cancer...
- Enhanced induction of anti-tumor immunity in human and mouse by dendritic cells pulsed with recombinant TAT fused human survivin proteinHyun Il Cho
Department of Microbiology, College of Medicine, Catholic University of Korea, 505 Banpo Dong, Seocho Gu, Seoul 137 701, South Korea
Cancer Lett 258:189-98. 2007..These results suggest that vaccination with DCs pulsed with tatSVV is an effective way for the SVV-targeting cancer vaccine to induce an effective anti-tumor responses...
- The role of T cell antagonism and original antigenic sin in genetic immunizationRana A K Singh
Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA
J Immunol 169:6779-86. 2002....
- Syngeneic mixed lymphocyte reaction (SMLR) with dendritic cells: direct visualization of dividing T cell subsets in SMLRToshimasa Aranami
Division of Immunobiology, Research Section of Pathophysiology, Institute for Genetic Medicine, Hokkaido University, Kita 15 Nishi 7 Kita ku, Sapporo 060 0815, Japan
Cell Immunol 217:67-77. 2002....
- Identification of effector-memory CMV-specific T lymphocytes that kill CMV-infected target cells in an HLA-E-restricted fashionPaola Mazzarino
Dipartimento di Oncologia, Biologia e Genetica, Universita degli Studi di Genova, Genova, Italy
Eur J Immunol 35:3240-7. 2005..Our data suggest that HLA-E-restricted CTL may represent an additional effector cell type involved in defenses against HCMV, a virus which escapes the control exerted by conventional CTL or NK cells...
- The adjuvant effects of Mycobacterium tuberculosis heat shock protein 70 result from the rapid and prolonged activation of antigen-specific CD8+ T cells in vivoLisa A E Harmala
Department of Laboratory Medicine and Pathology, Center for Immunology, Cancer Center, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
J Immunol 169:5622-9. 2002..These studies demonstrate that the potent adjuvant effect of M. tuberculosis hsp70 results from the relatively complete, rapid, and durable activation of Ag-specific CD8(+) T cells...
- High-affinity HLA-A(*)02.01 peptides from parathyroid hormone-related protein generate in vitro and in vivo antitumor CTL response without autoimmune side effectsGuido Francini
Division of Medical Oncology, Institut National de la Santé et de la Recherche Médicale Unité d Immunité Cellulaire Antivirale, Institut Pasteur, Paris, France
J Immunol 169:4840-9. 2002..In this study we describe two immunogenic and toxic-free PTH-rP peptides as valid candidates for the design of peptide-based vaccination strategies against prostate cancer and bone metastases from the most common epithelial malignancies...
- Most murine CD8+ intestinal intraepithelial lymphocytes are partially but not fully activated T cellsHeuy Ching Wang
Dental Branch, Department of Basic Sciences, University of Texas Health Science Center, Houston 77030, USA
J Immunol 169:4717-22. 2002..These data also imply that under appropriate conditions it is possible for T cells to be sustained in a state of partial activation...
- Targeting positive regulatory domain I-binding factor 1 and X box-binding protein 1 transcription factors by multiple myeloma-reactive CTLCarina Lotz
Department of Hematology and Oncology, Johannes Gutenberg University, Mainz, Germany
J Immunol 175:1301-9. 2005..We conclude that transcription factors governing terminal cellular differentiation may provide MM- and tumor-associated CTL epitopes...
- Thy-1 signaling in the context of costimulation provided by dendritic cells provides signal 1 for T cell proliferation and cytotoxic effector molecule expression, but fails to trigger delivery of the lethal hitS M Mansour Haeryfar
Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
J Immunol 171:69-77. 2003....
- Langerhans cells derived from genetically modified human CD34+ hemopoietic progenitors are more potent than peptide-pulsed Langerhans cells for inducing antigen-specific CD8+ cytolytic T lymphocyte responsesJianda Yuan
Laboratory of Cellular Immunobiology, Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
J Immunol 174:758-66. 2005..LCs genetically modified to express fluMP are also more potent stimulators of Ag-specific CD8(+) T cell responses than are peptide-pulsed LCs...
- Enhanced antilymphoma efficacy of CD19-redirected influenza MP1-specific CTLs by cotransfer of T cells modified to present influenza MP1Laurence J N Cooper
Beckman Research Institute, Division of Pediatric Hematology Oncology, City of Hope National Medical Center, Duarte, CA 91010 3000, USA
Blood 105:1622-31. 2005..Engineered T-APCs are a novel and versatile antigen-delivery system for generating antigen-specific T cells in vitro and enhancing the in vivo effector functioning of CAR-redirected antitumor effector cells...
- Antigen-specific T cells maintain an effector memory phenotype during persistent Trypanosoma cruzi infectionDiana L Martin
Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA
J Immunol 174:1594-601. 2005..These results suggest that T cells maintained in mice with chronic T. cruzi infection are fully functional memory cells that cannot be easily categorized in the current central/effector memory paradigm...
- Rapid conversion of effector mechanisms from NK to T cells during virus-induced lysis of allogeneic implants in vivoMichael A Brehm
Department of Pathology, University of Massachusetts Medical School, Worcester, 01655, USA
J Immunol 174:6663-71. 2005..This rapid generation of allospecific CTL activity during a viral infection preceded the peak of viral epitope-specific T cell responses, as detected by in vivo or in vitro cytotoxicity assays...
- Generation of potent antitumor CTL from patients with multiple myeloma directed against HM1.24Steven B Rew
Department of Haematology, Royal Free and University College Medical School, London, United Kingdom
Clin Cancer Res 11:3377-84. 2005..The purpose of this work was to test the suitability of the HM1.24 antigen as a CTL target for immunotherapy of patients with multiple myeloma...
- Age-dependent hantavirus-specific CD8(+) T-cell responses in mice infected with Hantaan virusK Araki
Laboratory of Public Health, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
Arch Virol 149:1373-82. 2004....
- Vaccination with dendritic cells pulsed in vitro with tumor antigen conjugated to cholera toxin efficiently induces specific tumoricidal CD8+ cytotoxic lymphocytes dependent on cyclic AMP activation of dendritic cellsJ B Sun
Department of Medical Microbiology and Immunology, and Göteborg University Vaccine Research Institute GUVAX, Goteborg University, S 405 30, Goteborg, Sweden
Clin Immunol 112:35-44. 2004....
- HLA-E-restricted recognition of human cytomegalovirus by a subset of cytolytic T lymphocytesChiara Romagnani
Dipartimento di Medicinia Sperimentale, Centro di Eccellenza per Ricerche Biomediche, Universita degli Studi di Genova, Genova, Italy
Hum Immunol 65:437-45. 2004..This broad ability to recognize and kill allogeneic cells may pose serious problems in transplantation...
- Definition of an immunogenic region within the ovarian tumor antigen stratum corneum chymotryptic enzymeKristina L Bondurant
Department of Microbiology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Clin Cancer Res 11:3446-54. 2005..In this study, we tested the hypothesis that dendritic cells loaded with SCCE peptides will induce ovarian tumor antigen-specific CD8+ CTL responses and antigen-specific CD4+ helper T cell responses...
- Injection of IL-12 gene-transduced dendritic cells into mouse liver tumor lesions activates both innate and acquired immunityT Tatsumi
Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Japan
Gene Ther 14:863-71. 2007..These results revealed that IL-12 gene transfer is capable of improving the impaired functions of DC isolated from tumor-bearing hosts, and support the preclinical therapeutic efficacy of intrahepatic injection of AdIL12DC...
- Enhanced tumor responses to dendritic cells in the absence of CD8-positive cellsAntoni Ribas
Department of Medicine, Division of Hematology Oncology, University of California, Los Angeles, CA 90095, USA
J Immunol 172:4762-9. 2004..Elucidation of the signaling events that activate these effective cytotoxic cells and the putative suppressive mechanisms in a wild-type environment may provide means to enhance the clinical activity of DC-based approaches...
- The VITAL assay: a versatile fluorometric technique for assessing CTL- and NKT-mediated cytotoxicity against multiple targets in vitro and in vivoIan F Hermans
Tumour Immunology Unit, Nuffield Department of Medicine, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK
J Immunol Methods 285:25-40. 2004..The VITAL assay is, therefore, a sensitive technique allowing analysis of complex multi-epitope responses...
- Differential susceptibility of cells expressing allogeneic MHC or viral antigen to killing by antigen-specific CTLKoutetsu Lee
Department of Physiology, Osaka Medical College, Takatsuki, Osaka, Japan
Microbiol Immunol 48:15-25. 2004..Taken together, these results suggest that not all in vivo tissues may be sensitive to CTL lysis...
- Mechanisms of superior anti-tumor cytotoxic response of interleukin 15-induced lymphokine-activated killer cellsOner Ozdemir
Division of Hematology Oncology, Children s Hospital of Michigan, Wayne State University, 3901 Beaubien Blvd, Detroit, MI 48201 2196, USA
J Immunother 28:44-52. 2005..These results are encouraging for potential use of IL-15 as part of immunotherapy...
- The immunodominant, Ld-restricted T cell response to hepatitis B surface antigen (HBsAg) efficiently suppresses T cell priming to multiple Dd-, Kd-, and Kb-restricted HBsAg epitopesReinhold Schirmbeck
Institute of Medical Microbiology and Immunology, University of Ulm, Ulm, Germany
J Immunol 168:6253-62. 2002....
- Experimental study of the efficacy of combined use of cancer vaccine and interferonG P Potebnya
R E Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, Kyiv, Ukraine
Exp Oncol 29:102-5. 2007..To study in in vivo model the efficacy of combined scheme of administration of cancer vaccine (CV) and interferon (IFN)...
- In vivo vaccination with tumor cell lysate plus CpG oligodeoxynucleotides eradicates murine glioblastomaAnhua Wu
Department of Neurosurgery, University of Minnesota Medical School, Minneapolis, MN 55455, USA
J Immunother 30:789-97. 2007..05). These results suggest direct vaccination with CpG/lysate provides an alternative and effective approach to induce host antitumor immunity and warrants clinical investigation in the immunotherapy of cancer...
- Cell death mediated by alloreactive cytotoxic T cells via the granule exocytosis or the Fas pathway is independent of p34cdc2 kinase: Fas dependent killing of cells arrested in the cell cycleP Waring
Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
Immunol Cell Biol 79:264-73. 2001..This lysis was accompanied by an increase in cell surface Fas expression. Olomoucine induced cell cycle arrest and expression of Fas was reversible and when cells re-entered the cell cycle, surface expression of Fas was lost...
- Generation of EBV-specific T cells for adoptive immunotherapy: a novel protocol using formalin-fixed stimulator cells to increase biosafetyMarkus H Hammer
Interdisciplinary Transplant Laboratory Nephrology Medical Immunology, Charite Universitatsmedizin Berlin, Germany
J Immunother 30:817-24. 2007..Furthermore, fixation will allow the use of transgenic LCLs (eg, with cytomegalovirus or tumor antigens) and thereby facilitate the generation of antigen-specific T cells directed against pathogens other than EBV...
- Genetically modified HLA class I molecules able to inhibit human NK cells without provoking alloreactive CD8+ CTLsAlexandra Sharland
Laboratory of Molecular and Cellular Immunology, Transplantation Biology Research Center, Boston, MA 02129, USA
J Immunol 168:3266-74. 2002..Such genetically modified molecules may have potential therapeutic applications in the prevention of delayed xenograft rejection and in the facilitation of allogeneic and xenogeneic bone marrow engraftment...
- Critical role for activation of antigen-presenting cells in priming of cytotoxic T cell responses after vaccination with virus-like particlesTazio Storni
Cytos Biotechnology, AG, Department of Dermatology and Institute of Experimental Immunology, University Hospital, and Elektronenmikroskopisches Zentrallabor Universität, Zurich, Switzerland
J Immunol 168:2880-6. 2002..Thus, while VLPs alone are inefficient at inducing CTL responses, they become very powerful vaccines if applied together with substances that activate APCs...
- MHC class I-restricted determinants on the glutamic acid decarboxylase 65 molecule induce spontaneous CTL activityA Quinn
Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
J Immunol 167:1748-57. 2001....
- Antigen delivered by anthrax lethal toxin induces the development of memory CD8+ T cells that can be rapidly boosted and display effector functionsChristine A Shaw
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
Infect Immun 76:1214-22. 2008..Finally, we demonstrated that mice that received prime-boost immunizations of LT-antigen proteins were more protected in a Listeria monocytogenes challenge model than mice that received only one immunization...
- An improved protocol for measuring cytotoxic T cell activity in anatomic compartments with low cell numbersT Ostler
Children's Hospital, University of Freiburg, Mathildenstrasse 1, D-79106, Freiburg, Germany
J Immunol Methods 257:155-61. 2001..Flow cytometric analysis of interferon-gamma production by virus-specific T cells including appropriate controls was achieved with as few as 10(5) effector cells...
- Activation of NK cell-mediated cytotoxicity by a SAP-independent receptor of the CD2 familyA Bouchon
Basel Institute for Immunology, Basel, Switzerland
J Immunol 167:5517-21. 2001..Thus, CRACC is a unique CD2-like receptor which mediates NK cell activation through a SAP-independent extracellular signal-regulated kinase-mediated pathway...
- Vaccination with allogeneic GM-CSF gene-modified lung cancer cells: antitumor activity comparing with that induced by autologous vaccineHui Li
Department of Immunology, Tianjin Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China
Cancer Biother Radiopharm 22:790-8. 2007..The immunogenic and antitumor activity of allogeneic vaccine was compared with that of autologous cancer cell vaccine...
- B-Myb overexpression results in activation and increased Fas/Fas ligand-mediated cytotoxicity of T and NK cellsM A Powzaniuk
Department of Microbiology and Immunology, Kimmel Cancer Center, Jefferson Medical College, Philadelphia, PA 19107, USA
J Immunol 167:242-9. 2001..Therefore, in addition to its well-established role in proliferation and differentiation, B-myb also appears to be involved in activation of NK and T cells and in their regulation of Fas/Fas ligand-mediated cytotoxicity..
- Activation-induced nonresponsiveness: a Th-dependent regulatory checkpoint in the CTL responseEe Loon Tham
Center for Immunology, Department of Biochemistry, University of Minnesota, Minneapolis, MN 55455, USA
J Immunol 168:1190-7. 2002..Once permission is given, in the form of IL-2, to pass this checkpoint, the CTL can make a prolonged response to persisting Ag in the absence of further CD4 T cell help...
- Generation of EBV-specific CD4+ cytotoxic T cells from virus naive individualsBarbara Savoldo
Center for Cell and Gene Therapy and Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
J Immunol 168:909-18. 2002..In addition, our method for selecting EBV-specific CTL from naive individuals by precursor cell enrichment may be applicable to the immunotherapy of cancer patients with a low frequency of tumor- or virus-specific CTL...
- Identification of known and novel immunogenic T-cell epitopes from tumor antigens recognized by peripheral blood T cells from patients responding to IL-2-based treatmentCarmen Scheibenbogen
Medizinische Klinik III, Hematology, Oncology and Transfusion Medicine, Universitaetsklinikum Benjamin Franklin, Freie Universitat Berlin, Berlin, Germany
Int J Cancer 98:409-14. 2002....
- Investigation of antigen delivery route in vivo and imune-boosting effects mediated by pH-sensitive liposomes encapsulated with K(b)-restricted CTL epitopeKi Young Lee
Department of Biotechnology, College of Engineering and Bioproducts Research Center, Yonsei University, 134 Shinchon dong, Seodaemun gu, Seoul, 120 749, South Korea
Biochem Biophys Res Commun 292:682-8. 2002..These results suggest that pH-sensitive liposome formula functions as a potential adjuvant of peptide antigens and is useful for the induction of antigen specific CTLsv in vivo...
- Multiple Chlamydia pneumoniae antigens prime CD8+ Tc1 responses that inhibit intracellular growth of this vacuolar pathogenBenjamin Wizel
Center for Pulmonary and Infectious Disease Control, Department of Microbiology and Immunology, University of Texas Health Center, Tyler 75708, USA
J Immunol 169:2524-35. 2002....
- Induction of murine gamma delta T cells cytotoxic for xenogeneic rat cellsC Okumura
Department of Plastic and Reconstructive Surgery, Nagasaki University School of Medicine, Japan
J Immunol 154:1114-23. 1995..V gamma 1 was detected as a major V gamma gene expressed in this gamma delta population by reverse transcriptase-PCR. Cytotoxicity for xenogeneic cells may represent one of major function of gamma delta T cells...
- Involvement of MHC class I molecule and ICAM-1 in the enhancement of adhesion and cytotoxic susceptibility to immune effector cells of tumor cells transfected with the interleukin (IL)-2, IL-4 or IL-6 geneX Cao
Department of Immunology, Second Military Medical University, Shanghai, PR China
J Cancer Res Clin Oncol 123:602-8. 1997....
- Antigen-dependent release of IFN-gamma by cytotoxic T cells up-regulates Fas on target cells and facilitates exocytosis-independent specific target cell lysisArno Mullbacher
Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
J Immunol 169:145-50. 2002..The results are discussed as to the possible relevance of the phenomenon in efficiency and regulation of the Tc cell response to infections by viruses...
- Regulation of the CTL response by macrophage migration inhibitory factorR Abe
Laboratories of. Vascular Biology and Medical Biochemistry, The Picower Institute for Medical Research, Manhasset, NY 11030, USA
J Immunol 166:747-53. 2001..These data provide the first evidence of an important role for MIF in the regulation and trafficking of anti-tumor T lymphocytes in vivo...
- A redundant role of the CD3 gamma-immunoreceptor tyrosine-based activation motif in mature T cell functionM C Haks
Division of Immunology, Division of Cellular Biochemistry, and Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands
J Immunol 166:2576-88. 2001..Therefore, if ITAMs can function in signal specification, it is likely that either the CD3delta and/or the CD3epsilon chains endow the TCR with qualitatively unique signaling functions...
- Branched and linear lipopeptide vaccines have different effects on primary CD4+ and CD8+ T-cell activation but induce similar tumor-protective memory CD8+ T-cell responsesAdriana Baz
Cooperative Research Centre for Vaccine Technology, Queensland Institute of Medical Research, Queensland 4029, Australia
Vaccine 26:2570-9. 2008..OVA epitope display was reduced in tumors that developed in some mice, suggesting CD8+ T-cell dependent selection...
- Innate immunity to viruses: control of vaccinia virus infection by gamma delta T cellsL K Selin
Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
J Immunol 166:6784-94. 2001..Thus, gammadelta T cells can be mediators of innate immunity to viruses, having a significant impact on virus replication early in infection in the presence or absence of the adaptive immune response...
- Clinical significance of HLA class I alleles on postoperative prognosis of lung cancer patients in JapanYoshika Nagata
Second Department of Surgery, University of Occupational and Environmental Health, School of Medicine, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu City, Fukuoka 807 8555, Japan
Lung Cancer 65:91-7. 2009..We previously reported the correlation between HLA alleles and the postoperative prognosis of 204 patients with non-small cell lung cancer (NSCLC). The present study was based on 695 patients with NSCLC to confirm these correlations...
- Evaluation of a novel mononuclear cell isolation procedure for serological HLA typingP Schlenke
Institute of Immunology and Transfusion Medicine, University of Luebeck School of Medicine, D23538 Luebeck, Germany
Clin Diagn Lab Immunol 5:808-13. 1998..The decreasing viability after 48 h limits the use of both methods for HLA typing and HLA antibody screening...
- Unfavorable prognosis of patients with non-small cell lung carcinoma associated with HLA-A2T So
Department of Surgery II, School of Medicine, University of Occupational and Environmental Health, Iseigaoka 1 1, Yahatanishi ku, Kitakyushu 807 8555, Japan
Lung Cancer 32:39-46. 2001..We studied types of HLA class I antigens in 204 resected non-small cell lung carcinoma (NSCLC) patients and also examined its correlation with clinicopathologic features and prognosis...
- Association between pemphigus vulgaris and human leukocyte antigen in Han nation of northeast ChinaLong Geng
Department of Dermatology, First Affiliated Hospital, China Medical University, Shenyang 110001
Chin Med Sci J 20:166-70. 2005..To investigate the relationship between pemphigus vulgaris (PV) and human leukocyte antigen (HLA) in Han nation of northeast China...
- [Camouflage of HLA-I antigen in lymphocyte surface]Yin ze Zhang
Department of Blood Transfusion, Nanfang Hospital, The First Military Medical University, Guangzhou 510515, China
Zhongguo Shi Yan Xue Ye Xue Za Zhi 11:622-4. 2003..It is suggested that the specific reaction between HLA-I antigen of lymphocyte and HLA-I antibodies can be completely camouflaged by mPEG-BTC in PBS (pH 7.4) under 22 degrees C room temperature...
- Differential calcium response in HeLa and HeLa-Fas cells by cytotoxic T lymphocytesE Marion Schneider
Sektion Experimentelle Anästhesiologie, Universitatsklinikum Ulm, Steinhovelstr 9, Ulm D 89075, Germany
Biochem Biophys Res Commun 301:159-66. 2003....
- Induction of cytotoxic granules in human memory CD8+ T cell subsets requires cell cycle progressionYuru Meng
Department of Pathology, University of Chicago, Chicago, IL 60637, USA
J Immunol 177:1981-7. 2006..The fact that granule induction can be achieved through TCR and CD28 ligation has implications for restoring lytic effector function in the context of antitumor immunity...
- Upregulation of cystatin M during the progression of oropharyngeal squamous cell carcinoma from primary tumor to metastasisNadarajah Vigneswaran
Department of Diagnostic Sciences, UT Houston Dental Branch Stomatology, Room 3 094G, 6516 John Freeman Avenue, Houston, TX 77030 3402, USA
Oral Oncol 39:559-68. 2003..Thus, we propose that elevated cystatin M expression aids metastasis by blocking intrinsic cathepsin B activity and rescuing tumor cells from TNF-induced apoptosis...
- Inhibition by interleukin-18 of the growth of Dunn osteosarcoma cellsTakuya Okamoto
Departments of Pathology and Orthopedic Surgery, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Hyogo 663 8501, Japan
J Interferon Cytokine Res 24:161-7. 2004..These results indicate that IL-18 inhibits the growth of Dunn osteosarcoma cells in vivo by enhancing the cytotoxic activity of CD8(+) T lymphocytes through the FasL-Fas system...
- Testing for equine arteritis virusA A Cullinane
Vet Rec 155:647-8. 2004
- Anti-SARS-CoV immunity induced by a novel CpG oligodeoxynucleotideMusheng Bao
Department of Molecular Biology, College of Basic Medicine, Jilin University, Changchun 130021, China
Clin Immunol 118:180-7. 2006..Together, BW001 represents a novel type of CpG ODN and may have potential for the development of treatment and prevention for SARS as well as other viral associated diseases...
- Effect of the V3 loop deletion of envelope glycoprotein on cellular responses and protection against challenge with recombinant vaccinia virus expressing gp160 of primary human immunodeficiency virus type 1 isolatesIrena Kiszka
Center for Neurovirology and Cancer Biology, Temple University, Philadelphia, Pennsylvania 19122, USA
J Virol 76:4222-32. 2002..The results from our studies provide insights into approaches for boosting the breadth of envelope-specific CTL responses...
- A functional role of HLA-G expression in human gliomas: an alternative strategy of immune escapeHeinz Wiendl
Department of Neurology, Medical School, University of Tubingen, Tubingen, Germany
J Immunol 168:4772-80. 2002..We conclude that the aberrant expression of HLA-G may contribute to immune escape in human glioblastoma...
- Degeneracy and repertoire of the human HIV-1 Gag p17(77-85) CTL responseJune Kan-Mitchell
Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
J Immunol 176:6690-701. 2006..This study suggests that agonist sequences can replace aberrantly immunogenic native epitopes for the rational design of vaccines targeting HIV-1...
- Cord blood-derived plasma factor (CBPF) potentiates the low cytokinetic and immunokinetic profile of bone marrow cells in pesticide victims suffering from Acquired Aplastic Anaemia (AAA): an in vitro correlateSujata Law
Department of Haematology, Immunology and Immuno Haematology Laboratory, School of Tropical Medicine, C R Avenue, Kolkata, India
Immunol Invest 35:209-25. 2006....
- Functional modulation of expanded CD8+ synovial fluid T cells by NK cell receptor expression in HLA-B27-associated reactive arthritisNicolas Dulphy
Laboratoire d Immunologie et d Histocompatibilité, INSERM U396, Centre G Hayem, Universite Paris VII, Institut Universitaire d Hematologie, Hopital Saint Louis, Avenue C Vellefaux, 75475 Paris Cedex 10, France
Int Immunol 14:471-9. 2002....
- Dual functions of fractalkine/CX3C ligand 1 in trafficking of perforin+/granzyme B+ cytotoxic effector lymphocytes that are defined by CX3CR1 expressionMiyuki Nishimura
KAN Research Institute, Kyoto, Japan
J Immunol 168:6173-80. 2002....
- Vascular endothelial cell apoptosis induced by anti-donor non-MHC antibodies: a possible injury pathway contributing to chronic allograft rejectionGordon D Wu
Department of Cardiothoracic Surgery, Keck School of Medicine, University of Southern California, Los Angeles, 90033, USA
J Heart Lung Transplant 21:1174-87. 2002..Non-major histocompatibility complex (non-MHC) alloantibodies may play a pathogenic role in chronic rejection but remain poorly characterized...
- In vivo cross-presentation of a soluble protein antigen: kinetics, distribution, and generation of effector CTL recognizing dominant and subdominant epitopesD Nelson
Department of Medicine, University of Western Australia, Nedlands, Australia
J Immunol 165:6123-32. 2000..Analysis of functional in vivo CTL responses demonstrated that, in the presence of strong ongoing responses to the dominant peptide, lytic activity of CTL directed at weaker epitopes is undetectable...
- Adenovirus DNA polymerase is recognized by human CD8+ T cellsAmita Joshi
Department of Microbiology, Thomas Jefferson University, Philadelphia, PA 19107, USA
J Gen Virol 90:84-94. 2009..Pol epitopes were well conserved among different Ad serotypes. Therefore, Pol is a promising target for immunotherapy of Ad disease...
- Midkine promoter-driven suicide gene expression and -mediated adenovirus replication produced cytotoxic effects to immortalised and tumour cellsL Yu
Division of Pathology, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuo Ku, Chiba 260 8717, Japan
Eur J Cancer 40:1787-94. 2004..The MK promoter-driven suicide gene therapy and -mediated replicative Ad can thereby produce cytotoxic effects to immortalized and tumour cells with minimal damage to normal cells...
- Vulnerability to Smallpox Due to Declining CTL ImmunityInnocent Mbawuike; Fiscal Year: 2003..By correlating these responses with vaccinia lesion sizes in new vaccinees, markers of severe complications from vaccinia vaccination may be identified. ..
- TH1 CYTOKINES AND IMPAIRED CD8* CTLS IN ELDERLYInnocent Mbawuike; Fiscal Year: 2001....
- Regulation of Polyoma Virus-Specific CD8+ T CellsARON LUKACHER; Fiscal Year: 2007..unreadable] [unreadable]..
- COCAINE SMOKING EFFECTS ON LUNG IMMUNITY & HOST DEFENSEMichael Roth; Fiscal Year: 2006..abstract_text> ..
- Exploiting porcine cytomegalovirus stealth mechanismsMARK CREW; Fiscal Year: 2005..The Phase I project will be deemed successful when we have identified specific genes from PCMV which impart stealth to pig cells in vitro when exposed to cells from the human immune system. ..
- HSV Immunotherapeutic VaccineDavid Koelle; Fiscal Year: 2005....
- Intradermal vaccinia:T-cell specificity and skin homingDavid Koelle; Fiscal Year: 2005..2) Measure E-selectin binding by vaccinia-specific CD8 cells, and 2.3) Compare CLA and E-selectin binding by vaccinia-specific T-cells in recent and distant vaccines. ..
- Ligand for Natural Cytotoxicity Receptor NKp44PORUNELLOOR MATHEW; Fiscal Year: 2008..This information will be useful in developing immune based treatment for cancer and other diseases. [unreadable] [unreadable] [unreadable] [unreadable]..
- Cellular Immunity to BK VirusSimon Lacey; Fiscal Year: 2005..Such information may be useful in guiding clinical management, and lay the foundation for possible future vaccines. ..
- HIV-1 Suppression by MHC class I restricted CD8 T CellsPaul Goepfert; Fiscal Year: 2008..Our findings will have important implications fro HIV immunopathogenesis and vaccine design by supplying an HIV-1 specific CD8 T cell phenotype that results in efficient HIV-1 control. [unreadable] [unreadable] [unreadable]..
- Antiviral Therapy for Polyomavirus InfectionARON LUKACHER; Fiscal Year: 2008..g., FDA-approved Gleevec) limit polyomavirus infection, a critical prelude for their potential therapeutic use to prevent polyomavirus reactivation in immunosuppressed individuals. [unreadable] [unreadable] [unreadable]..
- The role of dendritic cell-T cell interactions in the p*Mariana Kaplan; Fiscal Year: 2006..These could lead into the development of novel therapeutic interventions designed to reverse these abnormalities and abrogate or block the onset and/or severity of this disease. ..
- IMMUNOPATHOGENESIS OF ACUTE HIV-1 INFECTIONElizabeth Connick; Fiscal Year: 2007..abstract_text> ..
- Mucosal and Peripheral NK-T Cells in HIV InfectionOtto Yang; Fiscal Year: 2007..Exploring NK-T cells in HIV-1 infection could there have a high impact on the development of new strategies in prevention and treatment. [unreadable] [unreadable]..
- Immune Correlates of HSV-2 Disease SeverityDavid Koelle; Fiscal Year: 2007....
- Mechanisms of Leukocyte Recruitment During IPS After BMTKenneth Cooke; Fiscal Year: 2007..lymphocytes --> days 7-21 SA2: CXCR3 / IP-10 (CXCL10) and Mig (CXCL9) SA3: CCR2: / MCP-1 (CCL2) --> monocytes/macrophages --> days 14-28 SA4:CXCR2 / KC and MIP-2 (CXCL1) --> neutrophils --> days 21 to 42 ..
- Vector-based Generation of Monoclonal Antibodies against the CB2 ReceptorMichael Roth; Fiscal Year: 2007..This work has the capacity to significantly accelerate cannabinoid research. [unreadable] [unreadable] [unreadable]..
- AFP-Based Immunotherapy for Hepatocellular CarcinomaAntoni Ribas; Fiscal Year: 2006..In summary, I propose a clinically-oriented research program that translates this original work into novel, evidence-based immnunotherapy trials for hepatocellular carcinoma. ..
- Mechanisms of T-cell induced-APC cytotoxicity in lupusMariana Kaplan; Fiscal Year: 2006..The sponsor and the institution are committed to contributing protected time, career development and resources to the applicant. ..
- ALABAMA/ZAMBIA HIV VACCINE CLINICAL TRIALS UNIT (HVTU)Paul Goepfert; Fiscal Year: 2006..Recently, the Alabama clinic enrolled 125 higher-risk gay men in <5 months in the first US phase III trial. Plans for utilizing these cohorts and others are described. ..
- Anthrax DNA vaccine for non-invasive immunization on skinZhengrong Cui; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Conference-Safeguarding Adult/Pediatric Stem Cell DonorsEdward Snyder; Fiscal Year: 2004..This Symposium would address the need for such Standards and stimulate the process. AIM 3 will be to publish a summary of the Symposium in a nationally recognized Journal. ..
- Improving Gastrointestinal Recovery after RadiationGeorge Georges; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable]..
- RHESUS MACAQUE MODEL OF TUBERCULOSISDAVID LEWINSOHN; Fiscal Year: 2001..g., CT scans, quantitative culture of mycobacteria from BAL fluids and liver biopsies) which correlate with survival. ..
- CYTOKINES AS PREDICTORS OF DISEASE PROGRESSION IN SCLERODERMA LUNG DISEASEMichael Roth; Fiscal Year: 2009..It will also allow us to develop biologic markers and predictors of disease progression and to determine which patients would benefit most from treatment with cytotoxic therapy. ..
- THERAPY FOR AIDS CENTRAL NERVOUS SYSTEM LYMPHOMAMichael Caligiuri; Fiscal Year: 2002..The limitations of the animal model preclude its use for studying the pathogenesis of AIDS PCNSL. ..
- Vaccinia: T-cell immunity and homing to skinDavid Koelle; Fiscal Year: 2009..Our data will assist in evaluating the immunogenicity of these constructs. ..
- NK CELL ACTIVITY AND IBS ACROSS THE MENSTRUAL CYCLESandra Motzer; Fiscal Year: 2002..abstract_text> ..
- Schistosome Calpain as a Vaccine CandidatesAfzal Siddiqui; Fiscal Year: 2002..Of greater importance, these studies should provide new insight into immune mechanisms which can damage worm parasites and establish a model by which to subsequently study the effector mechanisms. ..
- CHARACTERIZATION OF HUMAN 2B4 AND 2B4 GENE KNOCKOUT MICEPORUNELLOOR MATHEW; Fiscal Year: 2004..The experiments proposed in this project should provide a clearer understanding of the role of 2B4 in modulating various functions of human NK cells and may reveal new insights and open new avenues for cancer immunotherapy. ..
- CD8+TCell Antiretroviral Mechanisms in Lymphoid TissueElizabeth Connick; Fiscal Year: 2003..These studies could provide important insight into the immunopathogenesis of HIV-1 infection and suggest alternative targets for immune therapies. ..
- IL-15 Characterization Through Experimental ImmunologyMichael Caligiuri; Fiscal Year: 2009..abstract_text> ..
- DONOR SPECIFIC IMMUNOSUPPRESSION TO TRACHEAL ALLOGRAFTSEric Genden; Fiscal Year: 2004..Specific Aim II will focus on alternative methods of inducing donor specific tolerance to tracheal allografts. Specific Aim III will focus on the behavior of the tracheal allograft and its affect upon the established state of tolerance. ..
- Innate-like hepatic CD1d-reative NKT cells:Liver DiseaseMark Exley; Fiscal Year: 2008..I. on acute HCV infection in chimpanzees, as well as on liver immunology and on 'NKT' cells in general. ..
- B7-DC Cross-linking antibody immunotherapySvetomir Markovic; Fiscal Year: 2008..If successful, this "proof-of-principle" clinical trial will justify further development of B7-DC XAb as a cancer therapeutic with potential universal application for all malignant disorders. [unreadable] [unreadable] [unreadable]..
- A tri-antigen nasal anthrax vaccine against toxins and vegetative bacilli Zhengrong Cui; Fiscal Year: 2008..The same vaccine or its modified version can also be used in agricultural industries to vaccinate cattle. [unreadable] [unreadable] [unreadable]..
- Characterization of a vaccine against Chlamydia trachomatisRHEA COLER; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Stem Cell Quality Assays: Correlation with Aging/HealthJOHN GRAHAM SHARP; Fiscal Year: 2010..This research will validate laboratory assays of stem cell compartment quality which can then be applied to clinical situations and may reveal blood cytokine assays with surrogate predictive value. ..
- Influence of Lactation on Postpartum Stress and ImmunityMAUREEN EDITH GROER; Fiscal Year: 2010..The immunology and endocrinology of the postpartum provides a lens through which to study autoimmune disease, as the postpartum is a critical period for development or exacerbation of many autoimmune diseases. ..
- MECHANISM OF RETINAL DAMAGE IN AUTOIMMUNE RETINOPATHYGrazyna Adamus; Fiscal Year: 2008..unreadable] [unreadable]..
- Immunosupression-Resistant Gene Modified Donor T CellsGeorge Georges; Fiscal Year: 2009..Results from these studies have the strong potential to be directly translated to future gene therapy clinical trials. ..
- Exercise & influenza immunity:Psychoneuroendocrine ModelMarian Kohut; Fiscal Year: 2004..The findings from this study may have relevance from both a clinical and basic research perspective, if moderate exercise is associated with enhanced anti-influenza immunity and improved protection from infection. ..
- THE ROLE OF ALPHA-DEFENSINS IN CYSTIC FIBROSIS LUNG DISEL Spencer; Fiscal Year: 2004..Following completion of this training and research, my long-term career interest will remain in the area of pathogenesis and applied clinical intervention of neutrophil-mediated pulmonary disease in pediatric patients. ..
- CMV DISRUPTION OF CONSTITUTIVE MHC CLASS IIW Waldman; Fiscal Year: 2004....
- EIAV Control by High Avidity Rev-Specific CTL ClonesROBERT MEALEY; Fiscal Year: 2005..The information obtained from the proposed studies should have implications for HIV-1 immunotherapy and vaccine design, where experiments of this type may be more difficult. ..
- CD8+ T cell cytokine production in HIV-1 infectionPaul Goepfert; Fiscal Year: 2005..An HIV-1 vaccine would also be enhanced by identifying CD8+ T cell epitopes that portend a favorable prognosis and are difficult for the virus to mutate (specific aims 2 and 3). ..
- Gene Modified Donor T Cell Infusion into Mixed ChimerasGeorge Georges; Fiscal Year: 2003..If successful, this study could translate into improved control of the GVH reaction and improved survival after allogeneic HCT. ..
- ANTIVIRAL ACTIVITY OF THE IMMUNOSUPPRESSANT LEFLUNOMIDEW Waldman; Fiscal Year: 2004....
- EARLY STAGES OF INFECTION BY NONENVELOPED VIRUSESMarie Chow; Fiscal Year: 2002..It is aticipated that the studies will provide the biochemical and biophysical make-up of the channel structure and allow the applicants to build a general model of the early stages of infection by nonenveloped viruses. ..
- The regulation of tumor immunity by NKT cellsMark Smyth; Fiscal Year: 2007..This proposal focuses clearly on a pivotal immune control mechanism that will influence many current and future immunotherapies. ..
- Recombinant T-cell Receptor Ligands for Treatment of UveitisGrazyna Adamus; Fiscal Year: 2006..To determine an effective treatment regimen for clinical rat AAU using RTLs. 2. To determine the abilities of RTLs to inhibit recurrent anterior and posterior uveitis in Lewis rats. [unreadable] [unreadable] [unreadable] [unreadable]..
- REGULATION OF HUMAN T-CELL IMMUNITY TO HCV ANTIGENSDAVID ECKELS; Fiscal Year: 2009..abstract_text> ..
- HSV-SERONEGATIVE PERSONS WITH AQUIRED IMMUNITY TO HSVChristine Posavad; Fiscal Year: 2002..abstract_text> ..
- HIV li-Key/Peptide VaccineMinzhen Xu; Fiscal Year: 2002..This entirely synthetic vaccine can be manufactured in a large scale and be given to those at high risk of HIV infection. ..
- li Suppression-enhanced HIV DNA VaccineMinzhen Xu; Fiscal Year: 2003..In a Phase II program Ii-RGC/gp120 DNA vaccines will be tested in non-human primates for the induction of a protective immune response against pathogenic HIV infection. ..
- HIGH AFFINITY AGONISTS OF HIV1 DEPENDENT FUSIONSylvie Blondelle; Fiscal Year: 2001..Furthermore, studies toward the understanding of the mechanisms of action of these antagonists will be initiated. ..
- ANTITUMOR IMMUNITY INDUCED BY FUSION CELLS VACCINATIONJianlin Gong; Fiscal Year: 2003..3). To assess the effectiveness of fusion cell vaccines in the prevention and treatment of spontaneous breast carcinoma in transgenic mice. ..
- EIAV Control by DNA Vaccine-Induced CTLROBERT MEALEY; Fiscal Year: 2006..The information obtained from the proposed studies should have implications for HIV-1 vaccine design, where experiments of this type may be more difficult. [unreadable] [unreadable]..
- Human Resistance to Herpes Simplex Virus InfectionsChristine Posavad; Fiscal Year: 2005..The data generated will be relevant to designing and evaluating strategies for HSV-2 preventative vaccines and immunotherapy. ..
- Facilitating Cells for Fetal Hematopoietic TransplantLaurence Shields; Fiscal Year: 2005..Future directions will be towards the use of this model to explore the role and function of developmentally regulated adhesion molecules and their receptors as they relate to fetal hematopoietic transplantation. ..
- The Role of CD4 on Natural Killer CellsHELENE BERNSTEIN; Fiscal Year: 2006....
- IMMUNOREGULATORY EFFECTS OF MUTATION IN HCV NS3 ANTIGENDAVID ECKELS; Fiscal Year: 2005..abstract_text> ..
- Interaction of Yersinia with dendritic cellsIgor Brodsky; Fiscal Year: 2007..This knowledge will be important in the development of future strategies against human pathogens. ..
- T Cell Reactive Epitopes of Shrimp TropomyosinGerald Gleich; Fiscal Year: 2008..Knowledge of the T-cell epitopes of shrimp tropomyosin will permit production of a vaccine and thus set the stage for a trial of T-cell epitope peptide therapy in allergy to shrimp. [unreadable] [unreadable] [unreadable]..
- Antibody in Defense Against Neonatal Candida InfectionsJOSEPH BLISS; Fiscal Year: 2008..As such, he will be in an ideal position to orchestrate the translation of basic science to the benefit of patients. ..