adoptive transfer

Summary

Summary: Form of passive immunization where previously sensitized immunologic agents (cells or serum) are transferred to non-immune recipients. When transfer of cells is used as a therapy for the treatment of neoplasms, it is called adoptive immunotherapy (IMMUNOTHERAPY, ADOPTIVE).

Top Publications

  1. ncbi Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
    Susan M Kaech
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, Georgia 30322, USA
    Nat Immunol 4:1191-8. 2003
  2. pmc Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo
    Xuyu Zhou
    Diabetes Center and the Department of Medicine, University of California, San Francisco, California, USA
    Nat Immunol 10:1000-7. 2009
  3. pmc In vivo analysis of dendritic cell development and homeostasis
    Kang Liu
    Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA
    Science 324:392-7. 2009
  4. pmc Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity
    Kai Hildner
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Science 322:1097-100. 2008
  5. ncbi IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis
    Yutaka Komiyama
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Immunol 177:566-73. 2006
  6. ncbi Selective stimulation of T cell subsets with antibody-cytokine immune complexes
    Onur Boyman
    Department of Immunology, IMM4, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 311:1924-7. 2006
  7. ncbi CD4+CD25+ regulatory T cells suppress differentiation and functions of Th1 and Th2 cells, Leishmania major infection, and colitis in mice
    Damo Xu
    Department of Immunology and Bacteriology, University of Glasgow, Glasgow, Scotland, United Kingdom
    J Immunol 170:394-9. 2003
  8. pmc Prevention of arthritis by interleukin 10-producing B cells
    Claudia Mauri
    The Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science Technology and Medicine, London W6 8 LH, United Kingdom
    J Exp Med 197:489-501. 2003
  9. ncbi Requirement for CD4 T cell help in generating functional CD8 T cell memory
    Devon J Shedlock
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 300:337-9. 2003
  10. pmc Adoptive cell transfer: a clinical path to effective cancer immunotherapy
    Steven A Rosenberg
    Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, USA
    Nat Rev Cancer 8:299-308. 2008

Detail Information

Publications323 found, 100 shown here

  1. ncbi Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
    Susan M Kaech
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, Georgia 30322, USA
    Nat Immunol 4:1191-8. 2003
    ..IL-7R(hi) effector cells contained increased amounts of antiapoptotic molecules, and adoptive transfer of IL-7R(hi) and IL-7R(lo) effector cells showed that IL-7R(hi) cells preferentially gave rise to memory ..
  2. pmc Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo
    Xuyu Zhou
    Diabetes Center and the Department of Medicine, University of California, San Francisco, California, USA
    Nat Immunol 10:1000-7. 2009
    ..Moreover, exFoxp3 cell numbers were higher in inflamed tissues in autoimmune conditions. Adoptive transfer of autoreactive exFoxp3 cells led to the rapid onset of diabetes...
  3. pmc In vivo analysis of dendritic cell development and homeostasis
    Kang Liu
    Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA
    Science 324:392-7. 2009
    ..Further cDC development involves cell division, which is controlled in part by regulatory T cells and fms-like tyrosine kinase receptor-3...
  4. pmc Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity
    Kai Hildner
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Science 322:1097-100. 2008
    ..Importantly, rejection of highly immunogenic syngeneic tumors was impaired in Batf3-/- mice. These results suggest an important role for CD8alpha+ dendritic cells and cross-presentation in responses to viruses and in tumor rejection...
  5. ncbi IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis
    Yutaka Komiyama
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Immunol 177:566-73. 2006
    ..IL-17 upon treatment with myelin digodendrocyte glycopritein was CD4+ T cells rather than CD8+ T cells, and adoptive transfer of IL-17(-/-) CD4+ T cells inefficiently induced EAE in recipient mice...
  6. ncbi Selective stimulation of T cell subsets with antibody-cytokine immune complexes
    Onur Boyman
    Department of Immunology, IMM4, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 311:1924-7. 2006
    ..Thus, different cytokine-antibody complexes can be used to selectively boost or inhibit the immune response...
  7. ncbi CD4+CD25+ regulatory T cells suppress differentiation and functions of Th1 and Th2 cells, Leishmania major infection, and colitis in mice
    Damo Xu
    Department of Immunology and Bacteriology, University of Glasgow, Glasgow, Scotland, United Kingdom
    J Immunol 170:394-9. 2003
    ..Our results therefore document that CD4+CD25+ regulatory T cells suppress both Th1 and Th2 cells and that these regulatory T cells have a profound therapeutic potential against diseases induced by both Th1 and Th2 cells in vivo...
  8. pmc Prevention of arthritis by interleukin 10-producing B cells
    Claudia Mauri
    The Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science Technology and Medicine, London W6 8 LH, United Kingdom
    J Exp Med 197:489-501. 2003
    ..Our results suggest a new role of a subset of B cells in controlling T cell differentiation and autoimmune disorders...
  9. ncbi Requirement for CD4 T cell help in generating functional CD8 T cell memory
    Devon J Shedlock
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 300:337-9. 2003
    ..These results demonstrate a previously undescribed role for CD4 help in the development of functional CD8 memory...
  10. pmc Adoptive cell transfer: a clinical path to effective cancer immunotherapy
    Steven A Rosenberg
    Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, USA
    Nat Rev Cancer 8:299-308. 2008
    ....
  11. pmc Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells
    Luca Gattinoni
    Center for Cancer Research, National Cancer Institute NCI, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 202:907-12. 2005
    ..Thus, the restricted availability of homeostatic cytokines can be a contributing factor to peripheral tolerance, as well as a limiting resource for the effectiveness of tumor-specific T cells...
  12. pmc Cancer regression in patients after transfer of genetically engineered lymphocytes
    Richard A Morgan
    Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Science 314:126-9. 2006
    Through the adoptive transfer of lymphocytes after host immunodepletion, it is possible to mediate objective cancer regression in human patients with metastatic melanoma...
  13. pmc Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer
    Srinivas Nagaraj
    H Lee Moffitt Cancer Center, University of South Florida, 12902 Magnolia Drive, Tampa, Florida 33647, USA
    Nat Med 13:828-35. 2007
    ..These data identify a previously unknown mechanism of T-cell tolerance in cancer that is also pertinent to many pathological conditions associated with accumulation of MDSCs...
  14. pmc Defective CD8 T cell memory following acute infection without CD4 T cell help
    Joseph C Sun
    Department of Immunology and the Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    Science 300:339-42. 2003
    ..The results highlight a previously undescribed role for CD4 help in promoting protective CD8 memory development...
  15. ncbi Conventional B2 B cell depletion ameliorates whereas its adoptive transfer aggravates atherosclerosis
    Tin Kyaw
    Vascular Biology and Atherosclerosis Laboratory, Baker IDI Heart and Diabetes Research Institute, Victoria, Australia
    J Immunol 185:4410-9. 2010
    ..b>Adoptive transfer of 5 × 10(6) or 5 × 10(7) conventional B2 B cells but not 5 × 10(6) B1 B cells to a lymphocyte-deficient ..
  16. ncbi Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts
    Jordi C Ochando
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Nat Immunol 7:652-62. 2006
    ..of pDC lymph node homing inhibited peripheral Treg cell development and tolerance induction, whereas adoptive transfer of tolerized pDCs induced Treg cell development and prolonged graft survival...
  17. pmc Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates
    Carolina Berger
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Clin Invest 118:294-305. 2008
    The adoptive transfer of antigen-specific T cells that have been expanded ex vivo is being actively pursued to treat infections and malignancy in humans...
  18. ncbi Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
    Mehrdad Matloubian
    Howard Hughes Medical Institute and Department of Microbiology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, California 94143 0414, USA
    Nature 427:355-60. 2004
    ..These findings establish that S1P1 is essential for lymphocyte recirculation and that it regulates egress from both thymus and peripheral lymphoid organs...
  19. ncbi Kruppel-like factor 2 regulates thymocyte and T-cell migration
    Corey M Carlson
    Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Nature 442:299-302. 2006
    ..Our findings suggest that KLF2 serves to license mature T cells for trafficking from the thymus and recirculation through secondary lymphoid tissues...
  20. ncbi Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells
    J Rodrigo Mora
    The Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 424:88-93. 2003
    ..These findings establish that Peyer's patch dendritic cells imprint gut-homing specificity on T cells, and thus license effector/memory cells to access anatomical sites most likely to contain their cognate antigen...
  21. pmc Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing
    Bengt Johansson-Lindbom
    Immunology Section, Lund University, BMC I 13, 221 84 Lund, Sweden
    J Exp Med 202:1063-73. 2005
    ..Collectively, these results demonstrate a unique function for LP-derived CD103+ MLN DCs in the generation of gut-tropic effector T cells...
  22. ncbi CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2
    Thomas R Malek
    Department of Microbiology and Immunology, University of Miami School of Medicine, FL 33101, USA
    Immunity 17:167-78. 2002
    ..b>Adoptive transfer of normal CD4(+)CD25(+) T cells into neonatal IL-2Rbeta-deficient mice prevented this lethal autoimmune ..
  23. pmc Cutting edge: IL-2 signals determine the degree of TCR signaling necessary to support regulatory T cell proliferation in vivo
    Tao Zou
    Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 189:28-32. 2012
    ..These findings also have therapeutic implications, as TCR signaling by Tregs may not be required when using IL-2 to increase Treg numbers for treatment of inflammatory disorders...
  24. pmc Skin-resident murine dendritic cell subsets promote distinct and opposing antigen-specific T helper cell responses
    Botond Z Igyarto
    Department of Dermatology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
    Immunity 35:260-72. 2011
    ..Langerin(+) dDCs also inhibited the ability of LCs and classic DCs to promote Th17 cell responses. This work demonstrates that skin-resident DC subsets promote distinct and opposing antigen-specific responses...
  25. ncbi Reversible MHC multimer staining for functional isolation of T-cell populations and effective adoptive transfer
    Michael Knabel
    Institute of Medical Microbiology, Immunology, and Hygiene, Technical University Munich, Munich, Germany
    Nat Med 8:631-7. 2002
    ....
  26. ncbi Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells
    Alexander Link
    Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland
    Nat Immunol 8:1255-65. 2007
    ..Our data suggest that lymph nodes and T zone fibroblastic reticular cells have a key function in naive CD4(+) and CD8(+) T cell homeostasis by providing a limited reservoir of survival factors...
  27. pmc Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice
    David Bending
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    J Clin Invest 119:565-72. 2009
    ..Induction of diabetes in NOD/SCID mice via adoptive transfer of Th1 cells from BDC2...
  28. pmc Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes
    David H Munn
    Department of Pediatrics, Institute for Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Clin Invest 114:280-90. 2004
    ..b>Adoptive transfer of DCs from TDLNs into naive hosts created profound local T cell anergy, specifically toward antigens ..
  29. ncbi Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses
    Mercedesz Balazs
    Division of Developmental and Clinical Immunology, Department of Microbiology, University of Alabama, Birmingham, AL 35294, USA
    Immunity 17:341-52. 2002
    ..In the absence of soluble TACI ligands, Ag-activated MZ- and B1-derived blasts lack survival signals and undergo apoptosis, resulting in severely impaired antibody responses...
  30. pmc Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes
    Anneli Jäger
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 183:7169-77. 2009
    ..that we could directly compare and characterize the encephalitogenic activity of each of these subsets upon adoptive transfer. We show that myelin oligodendrocyte glycoprotein-specific Th1, Th17, and Th9 cells but not Th2 cells induce ..
  31. pmc CC chemokine receptor (CCR)4 and the CCR10 ligand cutaneous T cell-attracting chemokine (CTACK) in lymphocyte trafficking to inflamed skin
    Y Reiss
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 194:1541-7. 2001
    ..We conclude that CTACK and CCR4 can both support homing of T cells to skin, and that either one or the other is required for lymphocyte recruitment in cutaneous delayed type hypersensitivity...
  32. ncbi Probiotics ameliorate recurrent Th1-mediated murine colitis by inducing IL-10 and IL-10-dependent TGF-beta-bearing regulatory cells
    Claudia Di Giacinto
    Immune Mediated Diseases Section, Department of Infectious, Parasitic, and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    J Immunol 174:3237-46. 2005
    ..These studies show that probiotic (VSL#3) administration during a remission period ameliorates the severity of recurrent colitis by inducing an immunoregulatory response involving TGF-beta-bearing regulatory cells...
  33. ncbi Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer
    Jeffrey S Miller
    Division Medical and Pediatric Hematology Oncology, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
    Blood 105:3051-7. 2005
    ..These findings suggest that haploidentical NK cells can persist and expand in vivo and may have a role in the treatment of selected malignancies used alone or as an adjunct to HCT...
  34. ncbi Helminth infection protects mice from anaphylaxis via IL-10-producing B cells
    Niamh E Mangan
    Department of Biochemistry, Trinity College, Dublin, Ireland
    J Immunol 173:6346-56. 2004
    ....
  35. pmc Adoptive transfer of IL-4Rα+ macrophages is sufficient to enhance eosinophilic inflammation in a mouse model of allergic lung inflammation
    Andrew Q Ford
    Center for Vascular and Inflammatory Diseases, University of Maryland, Baltimore, Baltimore, MD 21201, USA
    BMC Immunol 13:6. 2012
    ..Wild type TH2 cells were provided exogenously...
  36. ncbi CD4+CD25+ T cells prevent the development of organ-specific autoimmune disease by inhibiting the differentiation of autoreactive effector T cells
    Richard J DiPaolo
    Section of Cellular Immunology, Laboratory of Immunology, National Institutes of Health, Bethesda, MD 20892 1892, USA
    J Immunol 175:7135-42. 2005
    ..The primary effect of nTreg appeared to be inhibition of differentiation of autoantigen-specific T cells to Th1 effector cells, as reflected by a decrease in Ag-stimulated IFN-gamma production and a reduction in T-bet expression...
  37. pmc Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice
    Ravid Shechter
    Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel
    PLoS Med 6:e1000113. 2009
    ..The hypothesis of the current study is that a specific population of infiltrating monocyte-derived MPhi is functionally distinct from the inflammatory resident microglia and is essential for recovery from SCI...
  38. pmc Selective generation of gut tropic T cells in gut-associated lymphoid tissue (GALT): requirement for GALT dendritic cells and adjuvant
    Bengt Johansson-Lindbom
    Immunology Section, Dept of Cell and Molecular Biology, Lund University, BMC I 13, S 22184 Lund, Sweden
    J Exp Med 198:963-9. 2003
    ..Together, these results demonstrate that GALT DCs and T cell expression of CCR9 play critical and integrated roles during T cell homing to the gut...
  39. pmc The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance
    Hsi Hsien Lin
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, England, UK
    J Exp Med 201:1615-25. 2005
    ..Peripheral tolerance was restored in F4/80(-/-) mice by adoptive transfer of F4/80(+) APCs in both peripheral tolerance models, indicating a central role for the F4/80 molecule in ..
  40. pmc Regulatory T cells that recognize a ubiquitous stress-inducible self-antigen are long-lived suppressors of autoimmune arthritis
    Martijn J C van Herwijnen
    Department of Infectious Diseases and Immunology, Utrecht University, 3584 CL Utrecht, The Netherlands
    Proc Natl Acad Sci U S A 109:14134-9. 2012
    ....
  41. pmc Adoptive transfer of cytomegalovirus-specific CTL to stem cell transplant patients after selection by HLA-peptide tetramers
    Mark Cobbold
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham B15 2TT, England, UK
    J Exp Med 202:379-86. 2005
    ..b>Adoptive transfer of donor-derived CMV-specific CD8+ T cell clones has been shown to reduce the rate of viral reactivation; ..
  42. ncbi Trafficking of CAR-engineered human T cells following regional or systemic adoptive transfer in SCID beige mice
    Ana Caterina Parente-Pereira
    The CAR Mechanics Group, King s College London School of Medicine, Guy s Hospital Campus, St Thomas Street, London, SE1 9RT, UK
    J Clin Immunol 31:710-8. 2011
    ..In light of their established efficacy, regional administration of engineered human T cells represents an attractive therapeutic option to minimize toxicity in the treatment of selected malignancies...
  43. pmc Analysis of transgene-specific immune responses that limit the in vivo persistence of adoptively transferred HSV-TK-modified donor T cells after allogeneic hematopoietic cell transplantation
    Carolina Berger
    Fred Hutchinson Cancer Research Center, Clinical Research Division, Seattle, Washington 98109, USA
    Blood 107:2294-302. 2006
    ..The potency of gene-modified T cells to elicit robust and durable immune responses imply this approach might be used for vaccination to elicit T-cell responses to viral or tumor antigens...
  44. pmc A novel adoptive transfer model of chronic lymphocytic leukemia suggests a key role for T lymphocytes in the disease
    Davide Bagnara
    The Feinstein Institute for Medical Research, North Shore LIJ Health System, 350 Community Drive, Manhasset, NY 11030, USA
    Blood 117:5463-72. 2011
    ..of CLL cells, particularly cell maturation and growth in vivo, has been impeded by lack of a reproducible adoptive transfer model...
  45. pmc Abnormal T-cell reactivity against paternal antigens in spontaneous abortion: adoptive transfer of pregnancy-induced CD4+CD25+ T regulatory cells prevents fetal rejection in a murine abortion model
    Ana Claudia Zenclussen
    Institut fur Medizinische Immunologie, Biomedizinisches Forschungszentrum, Raum 2 0534, Charite, Campus Virchow Klinikum, Augustenburger Platz 1, D 13353, Berlin, Germany
    Am J Pathol 166:811-22. 2005
    ..from abortion mice in vitro whereas in vivo prevention of fetal rejection could only be achieved after adoptive transfer of Treg cells from normal pregnant mice...
  46. ncbi CD8 T cells specific for lymphocytic choriomeningitis virus require type I IFN receptor for clonal expansion
    Peter Aichele
    Institute for Medical Microbiology and Hygiene, Department of Immunology, University of Freiburg, Freiburg, Germany
    J Immunol 176:4525-9. 2006
    The role of type I IFN signaling in CD8 T cells was analyzed in an adoptive transfer model using P14 TCR transgenic CD8 T cells specific for lymphocytic choriomeningitis virus (LCMV) but deficient in type I IFNR...
  47. pmc Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen
    Laura A Johnson
    Surgery Branch, Hatfield Clinical Research Center, National Cancer Institute NIH, Bethesda, MD 20892, USA
    Blood 114:535-46. 2009
    ..This trial was registered at www.ClinicalTrials.gov as NCI-07-C-0174 and NCI-07-C-0175...
  48. pmc CCL25 mediates the localization of recently activated CD8alphabeta(+) lymphocytes to the small-intestinal mucosa
    Marcus Svensson
    Immunology Section, Department of Cell and Molecular Biology, Lund University, Lund, Sweden
    J Clin Invest 110:1113-21. 2002
    ....
  49. pmc Altering the distribution of Foxp3(+) regulatory T cells results in tissue-specific inflammatory disease
    Blythe D Sather
    Benaroya Research Institute, Seattle, WA 98101, USA
    J Exp Med 204:1335-47. 2007
    ..Thus, selectively altering T reg cell distribution in vivo leads to the development of tissue-specific inflammatory disease...
  50. pmc Adaptive immune features of natural killer cells
    Joseph C Sun
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, California 94143, USA
    Nature 457:557-61. 2009
    ..These self-renewing 'memory' NK cells rapidly degranulate and produce cytokines on reactivation. Adoptive transfer of these NK cells into naive animals followed by viral challenge results in a robust secondary expansion and ..
  51. ncbi Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet
    Susetta Finotto
    Critical Care and Pulmonary Division, Division of Gastroenterology, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 295:336-8. 2002
    ..Thus, T-bet deficiency, in the absence of allergen exposure, induces a murine phenotype reminiscent of both acute and chronic human asthma...
  52. ncbi Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo
    K S Schluns
    Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Nat Immunol 1:426-32. 2000
    ..Homeostatic proliferation of memory cells was also partially dependent on IL-7. These results point to IL-7 as a pivotal cytokine in T cell homeostasis...
  53. pmc Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis
    Masako Murai
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Nat Immunol 10:1178-84. 2009
    ..Our data indicate that IL-10 released from myeloid cells acts in a paracrine manner on T(reg) cells to maintain Foxp3 expression...
  54. pmc Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma
    Mark E Dudley
    Surgery Branch, National Cancer Institute, NIH, CRC 3 3940, 10 Center Dr MSC 1201, Bethesda MD 20892 1202, USA
    J Clin Oncol 23:2346-57. 2005
    We investigated the combination of lymphodepleting chemotherapy followed by the adoptive transfer of autologous tumor reactive lymphocytes for the treatment of patients with refractory metastatic melanoma.
  55. ncbi Transcriptional regulator Id2 mediates CD8+ T cell immunity
    Michael A Cannarile
    Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093, USA
    Nat Immunol 7:1317-25. 2006
    ....
  56. ncbi Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity
    Daniel H Kaplan
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 23:611-20. 2005
    ..Moreover, we showed that LCs act during the priming and not the effector phase. Thus, LCs not only were dispensable for CHS, but they served to regulate the response, a previously unappreciated function...
  57. ncbi Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells
    Christian Mottet
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    J Immunol 170:3939-43. 2003
    ..These studies suggest that manipulation of CD4(+)CD25(+) T cells may be beneficial in the treatment of chronic inflammatory diseases...
  58. pmc Regional CNS responses to IFN-gamma determine lesion localization patterns during EAE pathogenesis
    Jason R Lees
    Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Exp Med 205:2633-42. 2008
    ..We demonstrate, using an adoptive transfer system, that the ability of the central nervous system (CNS) to sense pathogenic T cell-produced IFN-gamma ..
  59. pmc The Th17-ELR+ CXC chemokine pathway is essential for the development of central nervous system autoimmune disease
    Thaddeus Carlson
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Exp Med 205:811-23. 2008
    ....
  60. ncbi CD8 T cell clonal expansion and development of effector function require prolonged exposure to antigen, costimulation, and signal 3 cytokine
    Julie M Curtsinger
    Department of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 171:5165-71. 2003
    ....
  61. pmc Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens
    Mark E Dudley
    Surgery Branch, National Cancer Institute, NIH, Bethesda, MD 20892 1201, USA
    J Clin Oncol 26:5233-9. 2008
    ..Here, we update that study and evaluate the safety and efficacy of two increased-intensity myeloablative lymphodepleting regimens...
  62. ncbi Adoptive transfer of pp65-specific T cells for the treatment of chemorefractory cytomegalovirus disease or reactivation after haploidentical and matched unrelated stem cell transplantation
    Tobias Feuchtinger
    Department of Pediatric Hematology Oncology, University Children s Hospital, Tubingen, Germany
    Blood 116:4360-7. 2010
    ..b>Adoptive transfer of CMV-specific T cells could reconstitute viral immunity after SCT and could protect from CMV-related ..
  63. pmc Functional and pathogenic differences of Th1 and Th17 cells in experimental autoimmune encephalomyelitis
    Helena S Domingues
    Department of Neuroimmunology, Max Planck Institute of Neurobiology, Martinsried, Germany
    PLoS ONE 5:e15531. 2010
    ....
  64. ncbi Adoptive transfer and selective reconstitution of streptamer-selected cytomegalovirus-specific CD8+ T cells leads to virus clearance in patients after allogeneic peripheral blood stem cell transplantation
    Anita Schmitt
    Department of Internal Medicine III, The Institute For Transfusion Medicine, and the Institute for Virology, University of Ulm, Ulm, Germany
    Transfusion 51:591-9. 2011
    ..Cytomegalovirus (CMV) disease constitutes a serious complication after allogeneic stem cell transplantation. For the clearance of CMV, CD8+ T cells are pivotal...
  65. ncbi In vivo developmental stages in murine natural killer cell maturation
    Sungjin Kim
    Howard Hughes Medical Institute and Rheumatology Division, Department of Internal Medicine, Barnes Jewish Hospital and Washington University School of Medicine, St Louis, MO 63110, USA
    Nat Immunol 3:523-8. 2002
    ....
  66. ncbi Induction of tolerance by adoptive transfer of Treg cells
    Kanji Nagahama
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Methods Mol Biol 380:431-42. 2007
    ..Thus, in vivo or in vitro, direct or indirect ways of alloantigen-specific expansion of naturally arising CD4+CD25+ Treg cells can establish antigen-specific dominant tolerance to allogeneic transplants...
  67. pmc T cell-positive selection uses self-ligand binding strength to optimize repertoire recognition of foreign antigens
    Judith N Mandl
    Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 38:263-74. 2013
    ....
  68. ncbi Tumor-specific CD4+ T cells render the tumor environment permissive for infiltration by low-avidity CD8+ T cells
    S B Justin Wong
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 180:3122-31. 2008
    ....
  69. ncbi CD25+ cell depletion hastens the onset of severe disease in collagen-induced arthritis
    Mary E Morgan
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 48:1452-60. 2003
    ..We wished to evaluate their potential for influencing systemic and chronic joint inflammation by investigating their involvement in collagen-induced arthritis (CIA)...
  70. ncbi Mechanisms of PDL1-mediated regulation of autoimmune diabetes
    Indira Guleria
    Transplantation Research Center, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Clin Immunol 125:16-25. 2007
    ..This concept was confirmed by adoptive transfer studies utilizing lymphocytes from BDC2.5 and 4.1 (CD4+) TCR transgenic mice and 8...
  71. ncbi Transfer of CD8(+) cells induces localized hair loss whereas CD4(+)/CD25(-) cells promote systemic alopecia areata and CD4(+)/CD25(+) cells blockade disease onset in the C3H/HeJ mouse model
    Kevin J McElwee
    Division of Dermatology, University of British Columbia, Vancouver, BC, Canada
    J Invest Dermatol 124:947-57. 2005
    ..However, systemic disease expression fate is, apparently determined by CD4(+)/CD25(-) cells, while CD4(+)/CD25(+) lymphocytes may play a predominantly regulatory role...
  72. pmc Cutting edge: the Th1 response inhibits the generation of peripheral regulatory T cells
    David Caretto
    Department of Pathology, University of California, San Francisco, San Francisco, CA 94143 0511, USA
    J Immunol 184:30-4. 2010
    ..These data support a role for Th1 effector molecules and transcription factors in the control of peripheral Treg generation and demonstrates the limited plasticity of Th1 populations...
  73. ncbi Adoptive transfer of macrophage from mice with depression-like behavior enhances susceptibility to colitis
    Jean Eric Ghia
    Farncombe Family Digestive Health Research Institute, Division of Gastroenterology, McMaster University, Hamilton, Ontario, Canada
    Inflamm Bowel Dis 17:1474-89. 2011
    ..We examined whether the locus of susceptibility to colitis in mice with depression-like behavior (DLB) resides with the macrophage and implicates the vagus nerve...
  74. ncbi Induction of GVHD-like skin disease by passively transferred CD8(+) T-cell receptor transgenic T cells into keratin 14-ovalbumin transgenic mice
    Akihiko Shibaki
    Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Invest Dermatol 123:109-15. 2004
    ....
  75. pmc Transition of late-stage effector T cells to CD27+ CD28+ tumor-reactive effector memory T cells in humans after adoptive cell transfer therapy
    Daniel J Powell
    Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1201, USA
    Blood 105:241-50. 2005
    ....
  76. pmc Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation
    Nadine Bollig
    Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Universitat Marburg, 35043 Marburg, Germany
    Proc Natl Acad Sci U S A 109:8664-9. 2012
    ..During chronic leishmaniasis, the draining Irf4(-/-) LNs disappeared because of massive cell death. Adoptive transfer of WT CD4(+) T cells or few L...
  77. ncbi DNA methylation controls Foxp3 gene expression
    Julia K Polansky
    Experimentelle Rheumatologie Experimentelle Immunregulation, Charite Universitaetsmedizin Berlin, Berlin, Germany
    Eur J Immunol 38:1654-63. 2008
    ..Together, our data suggest that TSDR is an important methylation-sensitive element regulating Foxp3 expression and demonstrate that epigenetic imprinting in this region is critical for establishment of a stable Treg lineage...
  78. pmc Mycobacterium tuberculosis-specific CD8+ T cells require perforin to kill target cells and provide protection in vivo
    Joshua S Woodworth
    Division of Rheumatology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 181:8595-603. 2008
    ..Moreover, adoptive transfer of immune CD8(+) T cells isolated from wild-type, but not perforin-deficient mice, protect recipient mice ..
  79. pmc Promoting transplantation tolerance; adoptive regulatory T cell therapy
    N Safinia
    MRC Centre for Transplantation, Guy s and St Thomas NHS Foundation Trust, London, UK
    Clin Exp Immunol 172:158-68. 2013
    ....
  80. pmc T cell transfer model of chronic colitis: concepts, considerations, and tricks of the trade
    Dmitry V Ostanin
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
    Am J Physiol Gastrointest Liver Physiol 296:G135-46. 2009
    ....
  81. ncbi Th type 1-stimulating activity of lung macrophages inhibits Th2-mediated allergic airway inflammation by an IFN-gamma-dependent mechanism
    C Tang
    Asthma Research Group, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Immunol 166:1471-81. 2001
    ..After OVA pulsing and adoptive transfer, lung macrophages selectively promoted a Th1 response in Ag-sensitized recipients and did not induce ..
  82. pmc Enhanced neointima formation following arterial injury in immune deficient Rag-1-/- mice is attenuated by adoptive transfer of CD8 T cells
    Paul C Dimayuga
    Division of Cardiology, Oppenheimer Atherosclerosis Research Center, Cedars Sinai Heart Institute, Los Angeles, California, United States of America
    PLoS ONE 6:e20214. 2011
    ....
  83. pmc Interleukin 15 controls both proliferation and survival of a subset of memory-phenotype CD8(+) T cells
    Adam D Judge
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 196:935-46. 2002
    ..Thus, subsets of memory-phenotype T cells differ radically in their sensitivity to IL-15...
  84. ncbi Adoptive transfer of macrophages ameliorates renal fibrosis in mice
    Masashi Nishida
    Department of Pediatric Cardiology and Nephrology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, Japan
    Biochem Biophys Res Commun 332:11-6. 2005
    We performed adoptive transfer of bone marrow-derived (BM) macrophages following pharmacological depletion of leukocytes in a mouse model of unilateral ureteral obstruction (UUO)...
  85. pmc Induced Foxp3(+) regulatory T cells: a potential new weapon to treat autoimmune and inflammatory diseases?
    Qin Lan
    Medicine Translation Center, Shanghai East Hospital, Tongji University, Shanghai 200120, China
    J Mol Cell Biol 4:22-8. 2012
    ..Proper generation and manipulation of iTregs used for cellular therapy may provide a promise for the treatment of many autoimmune and inflammatory diseases...
  86. ncbi Anti-myeloma activity of endogenous and adoptively transferred activated natural killer cells in experimental multiple myeloma model
    Evren Alici
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Exp Hematol 35:1839-46. 2007
    ....
  87. ncbi Chimeric antigen receptors for T cell immunotherapy: current understanding and future directions
    Kevin J Curran
    Memorial Sloan Kettering Cancer Center Bone Marrow Transplant Service, Department of Pediatrics, New York, NY, USA
    J Gene Med 14:405-15. 2012
    ..Most CARs are comprised of an antigen-binding domain, an extracellular spacer/hinge region, a trans-membrane domain and an intracellular signaling domain resulting in T cell activation after antigen binding...
  88. ncbi Effector T-cell differentiation during viral and bacterial infections: Role of direct IL-12 signals for cell fate decision of CD8(+) T cells
    Selina J Keppler
    Institute for Medical Microbiology and Hygiene, Department of Immunology, University of Freiburg, Germany
    Eur J Immunol 39:1774-83. 2009
    ..direct IL-12 signaling to CD8(+) T cells was analyzed in bacterial and viral infections using the P14 T-cell adoptive transfer model with CD8(+) T cells that lack the IL-12 receptor...
  89. ncbi Development of a novel transgenic mouse for the study of interactions between CD4 and CD8 T cells during graft rejection
    Benjamin D Ehst
    Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA
    Am J Transplant 3:1355-62. 2003
    ....
  90. ncbi IFN-α-producing PDCA-1+ Siglec-H- B cells mediate innate immune defense by activating NK cells
    Yan Bao
    National Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University, Shanghai, PR China
    Eur J Immunol 41:657-68. 2011
    ..monocytogenes infection. Adoptive transfer of PDCA-1(+) CD19(+) B cells to Btk(-/-) mice normalized their resistance to L. monocytogenes infection...
  91. pmc Human inhibitory receptor immunoglobulin-like transcript 2 amplifies CD11b+Gr1+ myeloid-derived suppressor cells that promote long-term survival of allografts
    Wei Zhang
    Department of Medicine, Center for Molecular Chaperone Radiobiology and Cancer Virology, Medical College of Georgia, Augusta, GA, USA
    Transplantation 86:1125-34. 2008
    ..One of the potential mechanisms in the immunosuppressive accomplishment of HLA-G-ILT2 interactions involves the expansion of myeloid-derived suppressor cells (MDSCs). The potential of MDSCs in transplantation has not yet been exploited...
  92. ncbi Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction
    Myung Shin Jeon
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Immunity 21:167-77. 2004
    ..Our results show a critical role for Cbl-b in the regulation of peripheral tolerance and anergy of T cells...
  93. ncbi A phase I trial of adoptive transfer of allogeneic natural killer cells in patients with advanced non-small cell lung cancer
    Eleni G Iliopoulou
    Cancer Immunology and Immunotherapy Center, Saint Savas Cancer Hospital, 171 Alexandras Avenue, 115 22, Athens, Greece
    Cancer Immunol Immunother 59:1781-9. 2010
    HLA-mismatched natural killer (NK) cells have shown efficacy in acute myeloid leukemia, and their adoptive transfer in patients with other malignancies has been proven safe...
  94. pmc Successful treatment of metastatic melanoma by adoptive transfer of blood-derived polyclonal tumor-specific CD4+ and CD8+ T cells in combination with low-dose interferon-alpha
    Els M E Verdegaal
    Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands
    Cancer Immunol Immunother 60:953-63. 2011
    A phase I/II study was conducted to test the feasibility and safety of the adoptive transfer of tumor-reactive T cells and daily injections of interferon-alpha (IFNα) in metastatic melanoma patients with progressive disease...
  95. ncbi Splenic CD8α⁺ dendritic cells undergo rapid programming by cytosolic bacteria and inflammation to induce protective CD8⁺ T-cell memory
    Laura Campisi
    Institut National de Santé et de Recherche Médicale Unité 924, Groupe Avenir, Valbonne, France
    Eur J Immunol 41:1594-605. 2011
    ..Thus, these data designate these cells as the best candidates to facilitate the development of cell-based vaccine therapy...
  96. pmc Enhancement of neutrophil function by interleukin-18 therapy protects burn-injured mice from methicillin-resistant Staphylococcus aureus
    Manabu Kinoshita
    Department of Microbiology, National Defense Medical College, Namiki 3 2, Tokorozawa 359 8513, Japan
    Infect Immun 79:2670-80. 2011
    ..IL-18 treatment increased the survival of NOD-SCID mice after burn injury and MRSA infection. An adoptive transfer of neutrophils using NOD-SCID mice also showed a beneficial effect of IL-18-activated neutrophils, similar ..
  97. ncbi CD25 is a marker for CD4+ thymocytes that prevent autoimmune diabetes in rats, but peripheral T cells with this function are found in both CD25+ and CD25- subpopulations
    L A Stephens
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    J Immunol 165:3105-10. 2000
    ..Phenotypic analysis of human thymocytes showed the presence of CD25+ cells in the same proportions as in rat thymus. The possible developmental relationship between CD25+ and CD25- regulatory T cells is discussed...
  98. pmc Immunosuppression by CD4+ regulatory T cells induced by chronic retroviral infection
    M Iwashiro
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 98:9226-30. 2001
    ..These results suggest a possible explanation for HIV- and human T cell leukemia virus-I-induced immunosuppression in the absence of T cell depletion...
  99. pmc Adoptive transfer of virus-specific and tumor-specific T cell immunity
    Carolina Berger
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Curr Opin Immunol 21:224-32. 2009
    The adoptive transfer of T cells isolated or engineered to have specificity for diseased cells represents an ideal approach for the targeted therapy of human viral and malignant diseases...
  100. pmc Functional blocking monoclonal antibodies against IL-12p40 homodimer inhibit adoptive transfer of experimental allergic encephalomyelitis
    Susanta Mondal
    Department of Neurological Sciences, Division of Neuroscience, Rush University Medical Center, Chicago, IL 60612, USA
    J Immunol 182:5013-23. 2009
    ..Taken together, our results suggest that p40(2) participates in the pathogenesis of EAE and that neutralization of p40(2) may be beneficial in multiple sclerosis patients...
  101. pmc Adoptive transfer of CD8(+) T cells from transforming growth factor beta receptor type II (dominant negative form) induces autoimmune cholangitis in mice
    Guo Xiang Yang
    Division of Rheumatology, University of California at Davis, Davis, CA 95616, USA
    Hepatology 47:1974-82. 2008
    ..Hence, we performed a rigorous series of adoptive transfer studies, transferring Ly5...

Research Grants69

  1. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  2. Novel Macrolide Th17 Inhibitors
    Jay K Kolls; Fiscal Year: 2012
    ..Selected compounds with potent IC50s will be tested in vivo in an adoptive transfer model using ovalbumin specific Th17 or Th1 cells IV as previously described...
  3. Monocyte activation and the role of CD11c in obesity-linked metabolic syndrome
    Huaizhu Wu; Fiscal Year: 2013
    ..by using animal models of obesity with hypercholesterolemia, and by in vitro flow adhesion assay and in vivo adoptive transfer of blood monocytes with or without CD11c;and Aim 3...
  4. Roles of oxidation and inflammation in aortic stiffening
    David G Harrison; Fiscal Year: 2013
    ..RAG-1-/- and IL-17-/- mice will not develop arterial stiffening during angiotensin II infusion, but that adoptive transfer of T cells will promote arterial stiffening in these animals...
  5. Regulation of vaccine-induced anti-fungal T17 cells
    MARCEL WUETHRICH; Fiscal Year: 2013
    ..established an in vitro screen with bone marrow derived dendritic cells from knockout mice and an in vivo adoptive transfer system to delineate the signaling adaptors, pathogen recognition receptors, and fungal ligands that induce ..
  6. Chemokine Decoy Receptor for Therapy of Autoimmune Arthritis
    Kanneganti Murthy; Fiscal Year: 2012
    ..donors treated in vivo with mR-421 produce substantially less pro-inflammatory cytokines and suppress EAE in adoptive transfer experiments...
  7. Defining the molecular determinants of the threshold for autoimmune arthritis
    Lih Yun Hsu; Fiscal Year: 2013
    ..of a TCR1 library generated from purified infiltrating T cells in the inflamed joints will be combined with adoptive transfer experiments to identify and clone the arthritogenic T cells from SKG mice...
  8. Regulation of Chronic Colitis by Mesenchymal Stem Cells
    Matthew B Grisham; Fiscal Year: 2013
    ..Several reports demonstrate that adoptive transfer of allogeneic or xenogeneic (human) MSCs successfully engraft in recipient mice or rats where they suppress ..
  9. Dietary Scavenging of Reactive Species in Lung Injury: Role of Macrophages
    THEA NOREEN GOLDEN; Fiscal Year: 2013
    ..Chimeric mice, created by adoptive transfer of green fluorescent protein positive bone marrow cells to wild type recipients, will serve to identif the ..
  10. Mechanisms of adaptive immunity to P. aeruginosa in the lung
    Gregory P Priebe; Fiscal Year: 2013
    ..protection from acute pneumonia and the mechanisms underlying protection will be evaluated by adoptive transfer experiments combined with passive immunization, by neutralization of IL-17 prior to challenging immunized ..
  11. Yale Autoimmunity Center of Excellence
    Kevan C Herold; Fiscal Year: 2013
    ..a similar fusion molecule attenuated spontaneous disease, disease induced with cyclophosphamide, and the adoptive transfer of disease...
  12. Chemokine Decoy Receptor: a novel therapy of IBD
    Kanneganti Murthy; Fiscal Year: 2012
    ..donors treated in vivo with mR-421 produce substantially less pro-inflammatory cytokines and suppress EAE in adoptive transfer experiments...
  13. Autoimmunity in the Mediation of Infectious Myocarditis
    Jay Reddy; Fiscal Year: 2013
    ..II dextramer staining, cytokine analysis, magnetic resonance microscopy imaging, active immunization and adoptive transfer experiments, and histology...
  14. Molecular and Cellular Mechanisms of IL-17 Signaling
    Xiaoxia Li; Fiscal Year: 2013
    ..neurons) resulted in significantly reduced EAE severity whether EAE was induced by active immunization or adoptive transfer of myelin-specific Th17 cells...
  15. HLA-D Region in Systemic Lupus Erythematosus Pathogenesis
    Shu Man Fu; Fiscal Year: 2013
    ..with single and dual (multiple) specificities to provide a large number of autoreactive T cells to establish adoptive transfer models to study the activation of single vs dual reactive T cells in vitro and in vivo;and 3) To demonstrate ..
  16. Eotaxin in Colitis and Colitis-Associated Carcinogenesis
    Lori A Coburn; Fiscal Year: 2013
    ..rodentium model, as well as eotaxin1+/+Rag2-/- and eotaxin1-/-Rag2-/- mice, with and without adoptive transfer of CD4+CD45RBhi effector T cells in the T cell transfer model...
  17. The role of regulatory T cells in biliary atresia
    Alexander Miethke; Fiscal Year: 2013
    ..In preliminary studies, we have shown that adoptive transfer of Treg-containing CD4+ cells prior to RRV inoculation constrained hepatic expansion of NK and CD8 ..
  18. A translational model of neuro-immune therapy for PTSD in veterans of the OEF/OIF
    Leonardo H Tonelli; Fiscal Year: 2013
    ..will employ the RAG2-/- deficient mice which lack functional T and B cells and reconstitution of T cells by adoptive transfer from BALB/c wild type mice in 2 behavioral models of PTSD...
  19. Role of T Cell Mediated Immunity In Emotion And Stress Responsiveness
    Leonardo H Tonelli; Fiscal Year: 2012
    ..the RAG2-/- deficient mice which lacks mature T lymphocytes, we plan to assess if reconstitution by adoptive transfer of in vitro differentiated T cells is a condition capable of inducing altered emotional behavior and ..
  20. GAMMA DELTA T CELLS IN LYME ARTHRITIS
    Ralph C Budd; Fiscal Year: 2011
    ..Finally, the in vivo role of Fas/FasL will be studied by adoptive transfer of FasL+ ?? T cells to mice bearing mutant FasL or lacking Fas, caspase-8, or c-FLIP selectively in ..
  21. IMMUNOLOGY OF UNIQUE TUMOR SPECIFIC ANTIGENS
    Hans Schreiber; Fiscal Year: 2013
    ..cloned and sequenced to generate (i) chimeric antibody receptors (CARs) for transduction into T cells for adoptive transfer and (ii) bispecific fusion proteins to engage the host's NK and T cells in the margins of large solid ..
  22. Role of ABCG1 in lipid homeostasis, inflammation and innate immunity
    ELIZABETH JOANNA TARLING; Fiscal Year: 2013
    ..Using adoptive transfer studies and Rag2-/-Ldlr-/- hyperlipidemic mice, I will then determine the relative contribution of differen ..
  23. Sphingolipids in Acute Kidney Injury
    MARK DOUGLAS OKUSA; Fiscal Year: 2013
    ..chimeric mice, immune cell ablation studies using diptheria toxin in susceptible transgenic mouse strains, adoptive transfer studies, and cultured immune cells to address mechanistic questions both in vivo and in vitro...
  24. Viral suppression of CNS autoimmunity
    Stephen A Stohlman; Fiscal Year: 2013
    ..that suppression of self reactivity is a residual effect of acute viral encephalomyelitis is tested by adoptive transfer of encephalitogenic Th1, Th9 and Th17 cells into persistently infected mice...
  25. T CELL RESPONSE TO MYELIN PROTEOLIPID PROTEIN
    Vijay K Kuchroo; Fiscal Year: 2013
    ..Th9 cells are not regulatory T cells but effector T cells that induce colitis and peripheral neuritis upon adoptive transfer into immunodeficient mice, however, what is their role in the induction of EAE has not been evaluated...
  26. Regulation of B cells in the CNS
    Cornelia Bergmann; Fiscal Year: 2013
    ..mice in which germinal center derived B cells are marked by fluorescence to isolate ASC and Bmem for adoptive transfer. Their CNS migration, differentiation and protective capacity will be monitored in recipients defective in ..
  27. Risk factor-enhanced microvascular responses to ischemia-reperfusion.
    D Neil Granger; Fiscal Year: 2013
    ..Mutant mice, bone marrow chimeras, and adoptive transfer strategies will be employed to assess the contribution of blood cell vs vessel wall AT1r to the injury ..
  28. Regulation of Immunoglobulin Class Switch in Aged Mice
    Bonnie B Blomberg; Fiscal Year: 2013
    ..with immunization with NP-KLH or NP-Ficoll (thymus-dependent and thymus-independent antigens) and adoptive transfer of combinations of young and old B/T cells into SCID mice will be done...
  29. Toward suicidal automation of porphyric Leishmania for photodynamic vaccination
    Kwang Poo Chang; Fiscal Year: 2010
    ..was elicited without apparent persistence of the parasites and with long-term memory, as shown by its adoptive transfer to naive animals...
  30. HCV in Alcoholics
    Jack R Wands; Fiscal Year: 2011
    ..CTL) immune responses following genetic immunization with a plasmid expressing NS5 protein by using adoptive transfer of syngeneic DCs...
  31. Mechanism of Bach1-Mediated Transcriptional Regulation and Immune Function
    David Baltimore; Fiscal Year: 2013
    ..Accordingly, bone marrow reconstitution and adoptive transfer experiments will be used to identify those immune cell(s) in which the intrinsic function of Bach1 modulates ..
  32. Epigenetic Control of T cell Autoimmunity
    Daniel L Mueller; Fiscal Year: 2010
    ..Experiments under this aim will model RA using an adoptive transfer of KRN TCR-transgenic T cells reactive to the natural autoantigen glucose-6-phosphate isomerase (GPI), and ..
  33. Osteoclasts from pluripotent stem cells as vectors to modify bone marrow environm
    Hector L Aguila; Fiscal Year: 2010
    ..are the best proof of concept on the feasibility of regenerative medicine therapies through the adoptive transfer of progenitors to replace damaged or non-functional tissues...
  34. The role of T lymphocytes in mediating hypertension during pregnancy
    Kedra L Wallace; Fiscal Year: 2013
    ..Our preliminary data indicate the RUPP is associated with elevated lymphocytes adoptive transfer of these T lymphocytes into normal pregnant rats causes hypertension and AT1-AA production...
  35. Neutrophil Accumulation in Bacterial Pneumonia
    Samithamby Jeyaseelan; Fiscal Year: 2013
    ..unique combination of in vivo and in vitro systems, including conditional KO mice, lentiviral transduction, adoptive transfer, and cytokine restoration strategies will be employed to address these Aims...
  36. Pro-inflammatory role of megakaryocytes in arthritis
    Peter A Nigrovic; Fiscal Year: 2013
    ..Since W/Wv platelets are normal in number and function, and since adoptive transfer of platelets fails to repair arthritis susceptibility, we propose the novel and important hypothesis that ..
  37. Long-lived B cell Immunity in the Respiratory Tract
    Nicole Baumgarth; Fiscal Year: 2013
    ..b>Adoptive transfer studies will assess the requirements for antigen and/or infection-induced inflammatory signals for their ..
  38. Epigenetic Regulation of Acute Lung Injury Resolution
    Benjamin Singer; Fiscal Year: 2013
    ..Multicolor flow cytometry and adoptive transfer of AZA-treated Tregs to injured lymphocyte-deficient mice will be used to define the effect of DNA ..
  39. Functional impact of dendritic cell phenotype in a mouse model of myositis
    Dana P Ascherman; Fiscal Year: 2010
    ..b>Adoptive transfer of organ-infiltrating lymphocytes from DC-immunized to naive mice will firmly establish the relationship ..
  40. Phase 1 Study of Umbilical Cord Blood-Derived T Cells in Malignant B Cells
    Elizabeth J Shpall; Fiscal Year: 2013
    ..However, relapse remains a major barrier to the therapeutic potential of UCBT. The adoptive transfer of T cells expressing a second generation CD19-specific chimeric antigen receptor (CAR) has been shown to ..
  41. Rho Kinase and Airway Hyperresponsiveness
    Stephanie A Shore; Fiscal Year: 2013
    ..In aim 2, we will assess the role of ROCKs in T lymphocytes during OVA challenge. Adoptive transfer of T lymphocytes derived from ROCK sufficient mice into ROCK1 and ROCK2 mice will be performed...
  42. PARTICIPATION OF PARP-1 IN THE PATHOGENESIS OF ASTHMA
    Hamid Boulares; Fiscal Year: 2013
    ..We will perform the proposed studies using an integrated approach that includes a mouse model, adoptive transfer, a primary cell culture system, viral vectors, and state of the art technology...
  43. Cytokine Modulation of Heme Oxygenase-1 in Chronic Kidney Transplant Rejection
    Anupam Agarwal; Fiscal Year: 2010
    ..In Aim 3, the hematopoietic cell lineage required for the effects of IL-10 will be determined using adoptive transfer of specific cell populations from HO-1 and HO-1+/+ mice following aortic and kidney transplantation...
  44. Mitochondrial Kv1.3 potassium channels and lymphocyte apoptosis in sepsis
    Jay Yang; Fiscal Year: 2011
    ..3 potassium channels and explore adoptive transfer of these genetically engineered T lymphocytes as a novel treatment for sepsis...
  45. Id3/B Lymphocytes and Atherosclerosis
    Coleen A McNamara; Fiscal Year: 2010
    ..b>Adoptive transfer of B cells from Id3+1+ ApoE-I- or Id3-1- ApoE-I- mice to jJMT ApoE-1 - mice lacking mature B cells provides ..
  46. T Cell-Mediated Mechanisms of Autoimmunity in Murine and Human Biliary Atresia
    CARA LYNN MACK; Fiscal Year: 2011
    ..autoreactive bile duct epithelial-specific T cells infiltrate the livers of RRV-induced BA mice, and that adoptive transfer of these T cells into naTve SCID recipients leads to bile duct targeted inflammation...
  47. Chemokines and Lymphoid Tissue Organization and Function
    Jason G Cyster; Fiscal Year: 2013
    ..We will use adoptive transfer approaches with immunoglobulin `knockin'B cells to study the impact on antibody affinity maturation of ..
  48. Sex differences in brain inflammation in experimental stroke
    Halina Offner; Fiscal Year: 2013
    ..splenectomy benefits the injured brain of both sexes by eliminating immunocytes nurtured within the spleen, adoptive transfer of female vs...
  49. Resolution and repair of acute lung injury by macrophage-derived iNOS
    FRANCO R D'ALESSIO; Fiscal Year: 2011
    ..b>Adoptive transfer of WT iNOS+/+ bone marrow-derived monocytes or direct adenoviral gene delivery of iNOS into injured iNOS-/- ..
  50. Engineered tumor-specific T cells Resist Hypoxic-Tumor Immunosuppressive Attacks.
    Patricia Yotnda; Fiscal Year: 2013
    ..Although adoptive transfer of cytotoxic T lymphocytes (CTLs) is a promising therapy for many cancers, they often fail to eliminate ..
  51. Dual role of the bradykinin B2 receptor during inflammation
    Bruce L Zuraw; Fiscal Year: 2013
    ..Third, the impact of B2R knockout on the development of inhalational tolerance will be assessed. Finally, adoptive transfer of dendritic cells from wild-type mice into B2R knockout mice will be performed to show whether this can ..
  52. Mechanisms of IVIG Protection in Viral Encephalitis
    EDOUARD M CANTIN; Fiscal Year: 2010
    ..In Aim 3, the IVIG 'sensor'cells (sDC) will be identified using an adoptive transfer strategy, it's role in protection will be investigated, including induction of Tregs and modulation of ..
  53. Very Late Antigen Integrin Activity on T Cells
    Yoji Shimizu; Fiscal Year: 2010
    ..In Aim 2, we will use conditional gene targeting and adoptive transfer approaches to define the function of beta l integrin expression in controlling integrin- dependent responses ..
  54. Myeloid-derived Suppressor Cells in Autoimmune Arthritis
    Katalin Mikecz; Fiscal Year: 2012
    ..Although conceptually similar to ABMT, this treatment will be reduced to the adoptive transfer of MDSCs, i.e...
  55. Involvement of Natural Killer T cells in Hepatic Fibrogenesis
    Ian N Hines; Fiscal Year: 2011
    ..will extend these findings and determine the role of NKT cell derived cytokines specifically using a novel adoptive transfer approach where NKT cell deficient mice are reconstituted with certain cytokine deficient NKT cells including ..
  56. dnTGF Beta RII Mice and PBC
    William M Ridgway; Fiscal Year: 2013
    ..Further, adoptive transfer of splenic dnTGF2-RII CD8+ T cells into B6 Rag1-/- mice transfers autoimmune cholangitis, whereas similar ..
  57. Resolution and repair of acute lung injury by macrophage-derived iNOS
    FRANCO R D'ALESSIO; Fiscal Year: 2013
    ..b>Adoptive transfer of WT iNOS+/+ bone marrow-derived monocytes or direct adenoviral gene delivery of iNOS into injured iNOS-/- ..
  58. Durable CD4+ T-cell Tumor Immunity Following Gene-modified HPSC
    Christopher E Touloukian; Fiscal Year: 2013
    ..Many of these treatments which have included potent cytokine infusions, the adoptive transfer of activated lymphocytes, and a wide array of cancer vaccines, have been largely applied to patients with ..
  59. The adoptive transfer of gene-modified T cells as a cell therapy for lymphoma
    MARCO L DAVILA; Fiscal Year: 2012
    ..It is expected that the results from this study will be used to develop optimized T cell therapies for patients with lymphoma. ..
  60. Amelioration of Immune Cell-Mediated Periodontal Disease
    Toshihisa Kawai; Fiscal Year: 2012
    ..the specific roles of T cells and B cells in mediating periodontal bone resorption in gingival challenge and adoptive transfer of T or B lymphocytes and an infection model of periodontal disease;and 2) two in vitro models for testing ..
  61. Non-CD4 Host defense against P. carinii Pneumonia
    Jay K Kolls; Fiscal Year: 2013
    ..b>Adoptive transfer of either B-cells or antibodies induced by the DC vaccine confer protection to scid mice demonstrating the ..
  62. Combination immunotherapy for neuroblastoma: model of innate tumor immunity
    Shakeel Modak; Fiscal Year: 2013
    ..b>Adoptive transfer of NK cell from a healthy allogeneic source may restore and enhance 3F8 effects in these poor-risk patients...
  63. Autologous TGF-B-Modified HSC for Repair of Vasodegenerative Diabetic Retinopathy
    STEPHEN BARTELMEZ; Fiscal Year: 2009
    ..To test this hypothesis we will use the adoptive transfer technique to deliver anti-TGF-2 PMO-modified CD34+ cells from the blood or bone marrow of patients with type ..
  64. T Cell Initiated Gastric Pathology
    ROBINNA LORENZ; Fiscal Year: 2007
    ..Using a novel adoptive transfer model of disease, we have shown that it is the host CD4+ T cell response which is crucial for the ..
  65. RENAL CELL CARCINOMA--ADOPTIVE IMMUNOTHERAPY
    KURT STENZEL; Fiscal Year: 1990
    ..term goal of this study is to develop successful immunotherapy for human renal cell carcinoma based on the adoptive transfer of autologous, mononuclear leukocytes (PBM) activated in a novel way (combined treatment with sodium ..
  66. Innate Effectors of rAls3p-N Anti-Candida Vaccine
    Brad J Spellberg; Fiscal Year: 2010
    ..are among the most common causes of nosocomial i mice;and 4) adoptive transfer of CD4+ T but neither B cells nor i We are developing an anti-candidal vaccine based on the recombinant N (..
  67. CD19-Specific T-Cell Therapy for Follicular Lymphoma
    LAURENCE COOPER; Fiscal Year: 2004
    ..b>Adoptive transfer of ex vivo-expanded autologous T cells rendered specific for CD19 is a method proposed to augment tumor-..
  68. Psychoneuroimmunology of T Cell Activation
    Steve Zalcman; Fiscal Year: 2004
    ..We have preliminary evidence that adoptive transfer of TH1 cells into syngeneic recipients induces a rapid increase in the incidence and intensity of ..
  69. Comparative Immunobiology of the bordetellae
    Eric Harvill; Fiscal Year: 2007
    ..In the mouse model, B cells are required to clear infection but adoptive transfer of immune serum had little effect on bacterial numbers, interpreted to mean B cells perform some function ..