passive immunization

Summary

Summary: Transfer of immunity from immunized to non-immune host by administration of serum antibodies, or transplantation of lymphocytes (ADOPTIVE TRANSFER).

Top Publications

  1. ncbi Protection against lethal enterovirus 71 infection in newborn mice by passive immunization with subunit VP1 vaccines and inactivated virus
    C N Wu
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, ROC
    Vaccine 20:895-904. 2001
  2. pmc Protection of Macaques against pathogenic simian/human immunodeficiency virus 89.6PD by passive transfer of neutralizing antibodies
    J R Mascola
    Division of Retrovirology, Walter Reed Army Institute of Research and Henry M Jackson Foundation, Rockville, Maryland 20850, USA
    J Virol 73:4009-18. 1999
  3. ncbi Passive immunization during pregnancy for congenital cytomegalovirus infection
    Giovanni Nigro
    Department of Pediatrics, La Sapienza University, Rome
    N Engl J Med 353:1350-62. 2005
  4. pmc Postnatal passive immunization of neonatal macaques with a triple combination of human monoclonal antibodies against oral simian-human immunodeficiency virus challenge
    R Hofmann-Lehmann
    Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Virol 75:7470-80. 2001
  5. pmc Antibody protects macaques against vaginal challenge with a pathogenic R5 simian/human immunodeficiency virus at serum levels giving complete neutralization in vitro
    P W Parren
    Departments of Immunology and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 75:8340-7. 2001
  6. pmc Individual and bivalent vaccines based on alphavirus replicons protect guinea pigs against infection with Lassa and Ebola viruses
    P Pushko
    Virology Division, United States Army Medical Research Institute for Infectious Diseases, Fort Detrick, Frederick, Maryland 21702, USA
    J Virol 75:11677-85. 2001
  7. ncbi Passive immunization of lactating mice with stanniocalcin-1 antiserum reduces mammary gland development, milk fat content, and postnatal pup growth
    Deenaz Zaidi
    Department of Physiology and Pharmacology, Faculty of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    Am J Physiol Endocrinol Metab 291:E974-81. 2006
  8. ncbi Meta-analysis: convalescent blood products for Spanish influenza pneumonia: a future H5N1 treatment?
    Thomas C Luke
    Bureau of Medicine and Surgery, U S Navy, Washington, DC, USA
    Ann Intern Med 145:599-609. 2006
  9. pmc Passive antibody administration (immediate immunity) as a specific defense against biological weapons
    Arturo Casadevall
    Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Emerg Infect Dis 8:833-41. 2002
  10. ncbi Passive immunization of rainbow trout, Oncorhynchus mykiss (Walbaum), against Flavobacterium psychrophilum, the causative agent of bacterial coldwater disease and rainbow trout fry syndrome
    B R LaFrentz
    Department of Fish and Wildlife Resources and the Aquaculture Research Institute, University of Idaho, Moscow, ID 83844 1136, USA
    J Fish Dis 26:371-84. 2003

Research Grants

Detail Information

Publications343 found, 100 shown here

  1. ncbi Protection against lethal enterovirus 71 infection in newborn mice by passive immunization with subunit VP1 vaccines and inactivated virus
    C N Wu
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, ROC
    Vaccine 20:895-904. 2001
    ..Our data indicated that inactivated virus is the choice of vaccine preparation capable of fulfilling the demand for effective control, and that VP1 subunit vaccines remain promising vaccine strategies that require further refinement...
  2. pmc Protection of Macaques against pathogenic simian/human immunodeficiency virus 89.6PD by passive transfer of neutralizing antibodies
    J R Mascola
    Division of Retrovirology, Walter Reed Army Institute of Research and Henry M Jackson Foundation, Rockville, Maryland 20850, USA
    J Virol 73:4009-18. 1999
    ..These data indicate a general correlation between in vitro neutralization and protection and suggest that a vaccine that elicits neutralizing antibody should have a protective effect against HIV-1 infection or disease...
  3. ncbi Passive immunization during pregnancy for congenital cytomegalovirus infection
    Giovanni Nigro
    Department of Pediatrics, La Sapienza University, Rome
    N Engl J Med 353:1350-62. 2005
    ..Currently, there is no effective intervention for a primary cytomegalovirus (CMV) infection during pregnancy...
  4. pmc Postnatal passive immunization of neonatal macaques with a triple combination of human monoclonal antibodies against oral simian-human immunodeficiency virus challenge
    R Hofmann-Lehmann
    Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Virol 75:7470-80. 2001
    ..6P. Thus, combination immunoprophylaxis with passively administered synergistic human MAbs may play a role in the clinical prevention of mother-to-infant transmission of HIV type 1...
  5. pmc Antibody protects macaques against vaginal challenge with a pathogenic R5 simian/human immunodeficiency virus at serum levels giving complete neutralization in vitro
    P W Parren
    Departments of Immunology and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 75:8340-7. 2001
    ..The significance of such substerilizing neutralizing antibody titers in the context of a potent cellular immune response is an important area for further study...
  6. pmc Individual and bivalent vaccines based on alphavirus replicons protect guinea pigs against infection with Lassa and Ebola viruses
    P Pushko
    Virology Division, United States Army Medical Research Institute for Infectious Diseases, Fort Detrick, Frederick, Maryland 21702, USA
    J Virol 75:11677-85. 2001
    ....
  7. ncbi Passive immunization of lactating mice with stanniocalcin-1 antiserum reduces mammary gland development, milk fat content, and postnatal pup growth
    Deenaz Zaidi
    Department of Physiology and Pharmacology, Faculty of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    Am J Physiol Endocrinol Metab 291:E974-81. 2006
    ..The purpose of this study was to lower serum levels of STC-1 in lactating mice through passive immunization so as to monitor the effects on mammary gland function and postnatal pup growth...
  8. ncbi Meta-analysis: convalescent blood products for Spanish influenza pneumonia: a future H5N1 treatment?
    Thomas C Luke
    Bureau of Medicine and Surgery, U S Navy, Washington, DC, USA
    Ann Intern Med 145:599-609. 2006
    ..Treatments for H5N1 influenza are unsatisfactory, and convalescent human plasma containing H5N1 antibodies could be an effective therapy during outbreaks and pandemics...
  9. pmc Passive antibody administration (immediate immunity) as a specific defense against biological weapons
    Arturo Casadevall
    Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Emerg Infect Dis 8:833-41. 2002
    ..This article proposes a biological defense initiative based on developing, producing, and stockpiling specific antibody reagents that can be used to protect the population against biological warfare threats...
  10. ncbi Passive immunization of rainbow trout, Oncorhynchus mykiss (Walbaum), against Flavobacterium psychrophilum, the causative agent of bacterial coldwater disease and rainbow trout fry syndrome
    B R LaFrentz
    Department of Fish and Wildlife Resources and the Aquaculture Research Institute, University of Idaho, Moscow, ID 83844 1136, USA
    J Fish Dis 26:371-84. 2003
    ..the role antibody plays in conferring protection to rainbow trout fry, Oncorhynchus mykiss (Walbaum), by passive immunization with convalescent serum or serum from adult rainbow trout immunized with F. psychrophilum, and goat anti-F...
  11. ncbi Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice
    Edward B Lee
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    J Biol Chem 281:4292-9. 2006
    b>Passive immunization of murine models of Alzheimer disease amyloidosis reduces amyloid-beta peptide (Abeta) levels and improves cognitive function...
  12. ncbi Passive immunization protects cynomolgus macaques against Puumala hantavirus challenge
    Jonas Klingstrom
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, S 171 77 Stockholm, Sweden
    Antivir Ther 13:125-33. 2008
    ..Presently, there is no effective prevention available for HFRS or HPS. Here, we studied the effect of passive immunization on the course of infection in cynomolgus macaques challenged with wild-type Puumala hantavirus (PUUV-wt).
  13. pmc Human monoclonal antibody combination against SARS coronavirus: synergy and coverage of escape mutants
    Jan Ter Meulen
    Crucell Holland B V, Leiden, Netherlands
    PLoS Med 3:e237. 2006
    ..Combinations of virus-neutralizing, noncompeting mAbs may have these properties...
  14. doi Antibodies targeting linear determinants of the envelope protein protect mice against West Nile virus
    Michel Ledizet
    L2 Diagnostics, Department of Internal Medicine, Yale School of Medicine, 300 George Street, New Haven, CT 06525, USA
    J Infect Dis 196:1741-8. 2007
    ..These immunoglobulins recognized the E proteins of related flaviviruses, demonstrating that antibodies targeting specific E protein epitopes could be developed for prevention and treatment of multiple flavivirus infections...
  15. ncbi Cost of hospitalization for respiratory syncytial virus chest infection and implications for passive immunization strategies in a developing nation
    P W K Chan
    Division of Respiratory Medicine, Department of Paediatric, University Malaya Medical Centre, Kuala Lumpur, Malaysia
    Acta Paediatr 92:481-5. 2003
    ..in the treatment of children hospitalized with RSV chest infection and the potential cost-savings with passive immunization for high-risk infants...
  16. ncbi Prophylactic and therapeutic efficacy of human intravenous immunoglobulin in treating West Nile virus infection in mice
    David Ben-Nathan
    Department of Infectious Diseases, Israel Institute for Biological Research, Ness Ziona, Israel
    J Infect Dis 188:5-12. 2003
    ..These results indicate that antibodies play a major role in protection and recovery from WNV infection and that IVIG can be used as first-line therapy...
  17. ncbi An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus
    Elisabetta Traggiai
    Institute for Research in Biomedicine, Via Vela 6, CH 6500 Belllinzona, Switzerland
    Nat Med 10:871-5. 2004
    ..These results show that it is possible to interrogate the memory repertoire of immune donors to rapidly and efficiently isolate neutralizing antibodies that have been selected in the course of natural infection...
  18. pmc Prior infection and passive transfer of neutralizing antibody prevent replication of severe acute respiratory syndrome coronavirus in the respiratory tract of mice
    Kanta Subbarao
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 78:3572-7. 2004
    ..Thus, antibodies, acting alone, can prevent replication of the SARS coronavirus in the lung, a promising observation for the development of vaccines, immunotherapy, and immunoprophylaxis regimens...
  19. ncbi Delay of HIV-1 rebound after cessation of antiretroviral therapy through passive transfer of human neutralizing antibodies
    Alexandra Trkola
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Ramistrasse 100, 8091 Zurich, Switzerland
    Nat Med 11:615-22. 2005
    ..Only two of eight chronically infected individuals showed evidence of a delay in viral rebound during the passive immunization. Rebound in antibody-treated acutely infected individuals upon cessation of ART was substantially later ..
  20. pmc Passive immunity in prevention and treatment of infectious diseases
    M A Keller
    Department of Pediatrics, UCLA School of Medicine, Harbor UCLA Medical Center, Torrance, California 90509 2910, USA
    Clin Microbiol Rev 13:602-14. 2000
    ..The development and use of additional monoclonal antibodies to key epitopes of microbial pathogens may further define protective humoral responses and lead to new approaches for the prevention and treatment of infectious diseases...
  21. pmc Efficacy of killed virus vaccine, live attenuated chimeric virus vaccine, and passive immunization for prevention of West Nile virus encephalitis in hamster model
    Robert B Tesh
    University of Texas Medical Branch, Galveston 77555, USA
    Emerg Infect Dis 8:1392-7. 2002
    ..included a killed virus veterinary vaccine, a live attenuated chimeric virus vaccine candidate, and passive immunization with WNV-immune serum; all were tested by using a hamster model of the disease...
  22. ncbi An outline of the role of anti-Candida antibodies within the context of passive immunization and protection from candidiasis
    A Cassone
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Curr Mol Med 5:377-82. 2005
    ....
  23. ncbi Transmission of HTLV-I by blood transfusion and its prevention by passive immunization in rabbits
    R Kataoka
    Department of Medicine, Kochi Medical School, Japan
    Blood 76:1657-61. 1990
    ..To determine the ability of passive immunization to protect against HTLV-I infection, two groups of three rabbits were first transfused with 5 mL of blood ..
  24. ncbi Passive immunization with anti-ganglioside antibodies directly inhibits axon regeneration in an animal model
    Helmar C Lehmann
    Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    J Neurosci 27:27-34. 2007
    ....
  25. ncbi Prevention of hepatitis A through active or passive immunization: recommendations of the Advisory Committee on Immunization Practices (ACIP)
    Anthony E Fiore
    Division of Viral Hepatitis, National Center for Infectious Diseases, Atlanta, GA 30333, USA
    MMWR Recomm Rep 55:1-23. 2006
    ..Prevention of hepatitis A through active or passive immunization: recommendations of the Advisory Committee on Immunization Practices [ACIP]. MMWR 1999:48[No...
  26. ncbi The in vitro and in vivo protective activity of monoclonal antibodies directed against Hantaan virus: potential application for immunotherapy and passive immunization
    Zhikai Xu
    Department of Microbiology, the Fourth Medical University of PLA, Xi an, 710032, People s Republic of China
    Biochem Biophys Res Commun 298:552-8. 2002
    ..Phase II clinical trials of these neutralizing MAbs for emergent treatment of patients with HTNV infection in early stages of HRFS are carried out in endemic areas in China...
  27. pmc Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis
    Hong Ji
    Section on Immunology and Immunogenetics, Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Exp Med 196:77-85. 2002
    ..The variability in the requirement for TNF-alpha, reminiscent of that observed in treated rheumatoid arthritis patients, did not appear genetically programmed but related instead to subtle environmental changes...
  28. ncbi Cutting edge: the spirochetemia of murine relapsing fever is cleared by complement-independent bactericidal antibodies
    S E Connolly
    Center for Infectious Diseases, Department of Molecular Genetics and Microbiology, State University of New York, Stony Brook, NY 11794, USA
    J Immunol 167:3029-32. 2001
    ..Additionally, B cell-deficient mice passively immunized with immune IgM and with immune serum were protected from challenge...
  29. pmc Efficiency of protection of guinea pigs against infection with Bacillus anthracis spores by passive immunization
    David Kobiler
    Department of Infectious Diseases, Israel Institute for Biological Research, Ness Ziona 74100, Israel
    Infect Immun 70:544-60. 2002
    The efficacy of passive immunization as a postexposure prophylactic measure for treatment of guinea pigs intranasally infected with Bacillus anthracis spores was evaluated...
  30. ncbi Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. Science, 1985, 229(4716):869-871. Classical article
    B Beutler
    Laboratory of Medical Biochemistry, Rockefeller University, New York, NY 10021, USA
    J Immunol 181:7-9. 2008
  31. pmc Passive immunization with a nicotine-specific monoclonal antibody decreases brain nicotine levels but does not precipitate withdrawal in nicotine-dependent rats
    SAMUEL A ROIKO
    Minneapolis Medical Research Foundation, Minneapolis, MN 55404, USA
    Pharmacol Biochem Behav 93:105-11. 2009
    Vaccination against nicotine is under investigation as a treatment for tobacco dependence. Passive immunization with nicotine-specific antibodies represents a complementary strategy to vaccination...
  32. pmc Protection from Streptococcus pneumoniae keratitis by passive immunization with pneumolysin antiserum
    Sherrina N Green
    Department of Microbiology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Invest Ophthalmol Vis Sci 49:290-4. 2008
    To determine whether passive immunization with pneumolysin antiserum can reduce corneal damage associated with pneumococcal keratitis.
  33. ncbi Intervention with Shiga toxin (Stx) antibody after infection by Stx-producing Escherichia coli
    I Matise
    Veterinary Medical Research Institute, Iowa State University, Ames, Iowa, USA
    J Infect Dis 183:347-350. 2001
    ..High-dose antibody treatment also reduced the incidence and extent of vascular lesions. The degree of protection depended on the dose of antibody and the time of administration...
  34. ncbi A new alternative method for superovulation using passive immunization against inhibin in adult rats
    Harumichi Ishigame
    Laboratory of Veterinary Physiology, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183 8509, Japan
    Biol Reprod 71:236-43. 2004
    ..These results indicate that immunoneutralization of endogenous inhibin is a new practical alternative for induction of superovulation as a substitution for eCG-hCG method in the adult rat...
  35. ncbi Differential effects of passive immunization with nicotine-specific antibodies on the acute and chronic distribution of nicotine to brain in rats
    P R Pentel
    Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55422, USA
    J Pharmacol Exp Ther 317:660-6. 2006
    Vaccination against nicotine blocks or attenuates nicotine-related behaviors relevant to addiction in rats. Passive immunization with nicotine-specific antibodies is an alternative to vaccination with the potential advantages of allowing ..
  36. pmc Therapeutic versus neuroinflammatory effects of passive immunization is dependent on Aβ/amyloid burden in a transgenic mouse model of Alzheimer's disease
    S Sakura Minami
    Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road NW, Washington, DC 20057, USA
    J Neuroinflammation 7:57. 2010
    b>Passive immunization with antibodies directed to Aβ decreases brain Aβ/amyloid burden and preserves memory in transgenic mouse models of Alzheimer's disease (AD)...
  37. ncbi Modification of primary and recurrent genital herpes in guinea pigs by passive immunization
    Nigel Bourne
    Children s Hospital Medical Center, Division of Infectious Diseases, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    J Gen Virol 83:2797-801. 2002
    ..The amount of DNA in the ganglia of As+72-treated animals was not significantly lower than that of controls. These observations have implications for both the dynamics of latency establishment and desirable vaccine characteristics...
  38. doi Passive immunization with llama single-domain antibody fragments reduces foot-and-mouth disease transmission between pigs
    M M Harmsen
    Central Veterinary Institute of Wageningen UR, P O Box 65, 8200 AB Lelystad, The Netherlands
    Vaccine 27:1904-11. 2009
    We aim to develop a method that confers rapid protection against foot-and-mouth disease (FMD) by passive immunization with recombinant llama single-domain antibody fragments (VHHs)...
  39. pmc Evaluation of human monoclonal antibody 80R for immunoprophylaxis of severe acute respiratory syndrome by an animal study, epitope mapping, and analysis of spike variants
    Jianhua Sui
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, 44 Binney St, JFB 824, Boston, MA 02115, USA
    J Virol 79:5900-6. 2005
    ..Our study also cautions that for any prophylaxis strategy based on neutralizing antibody responses, whether by passive or active immunization, a genotyping monitor will be necessary for effective use...
  40. ncbi Meningoencephalitis associated with passive immunization of a transgenic murine model of Alzheimer's amyloidosis
    Edward B Lee
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, HUP, Philadelphia, 19104 4283, USA
    FEBS Lett 579:2564-8. 2005
    ..We have identified cases of meningoencephalitis subsequent to peripheral and intracerebral passive immunization of Tg2576 mice...
  41. ncbi Transferrin-binding proteins isolated from Neisseria meningitidis elicit protective and bactericidal antibodies in laboratory animals
    B Danve
    , Marcy l Etoile, France
    Vaccine 11:1214-20. 1993
    ..The survival rate in immunized mice was much higher than in control groups. In both active and passive immunization experiments mice were protected against at least 100 LD50...
  42. pmc Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization
    Igor Klyubin
    Institute of Neuroscience and Department of Pharmacology and Therapeutics, Trinity College, Dublin 2, Ireland
    J Neurosci 28:4231-7. 2008
    ..Abeta monomer isolated from human CSF did not affect long-term potentiation. These results strongly support a strategy of passive immunization against soluble Abeta oligomers in early Alzheimer's disease.
  43. pmc Targeting the extracellular membrane-proximal domain of membrane-bound IgE by passive immunization blocks IgE synthesis in vivo
    Stefan Feichtner
    Department of Molecular Biology, University of Salzburg, Salzburg, Austria
    J Immunol 180:5499-505. 2008
    ..The interaction between the monoclonal anti-mIgE Ab and mIgE induces receptor-mediated apoptosis in vitro. Passive immunization experiments lead to a block of newly synthesized specific IgEs during a parallel application of recombinant ..
  44. ncbi Active and passive immunization for atherosclerosis
    Kuang Yuh Chyu
    Cedars Sinai Medical Center and David Geffen School of Medicine at UCLA, Division of Cardiology and Atherosclerosis Research Center, Suite 5347, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
    Curr Opin Mol Ther 9:176-82. 2007
    ..the role of immune mechanisms in atherosclerosis and the potential atheroprotective effects of active or passive immunization strategies...
  45. ncbi Passive immunization of mice pups through oral immunization of dams with a plant-derived vaccine
    Amanda M Walmsley
    Boyce Thomspon Institute for Plant Research, Inc, Cornell University, Ithaca, NY 14853, USA
    Immunol Lett 86:71-6. 2003
    b>Passive immunization plays an important role in protecting young mammals against pathogens before the maturation of their own immune systems...
  46. pmc Passive immunization with melanin-binding monoclonal antibodies prolongs survival of mice with lethal Cryptococcus neoformans infection
    A L Rosas
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Infect Immun 69:3410-2. 2001
    b>Passive immunization with monoclonal antibodies (MAbs) to melanin prolonged the survival of and reduced the fungal burden in Cryptococcus neoformans-infected mice in comparison to controls...
  47. ncbi Passive immunization against nicotine attenuates nicotine discrimination
    David H Malin
    University of Houston Clear Lake, TX 77058, USA
    Life Sci 70:2793-8. 2002
    ..The results suggest that passive immunization can interfere with the stimulus properties of nicotine.
  48. ncbi Passive immunization with monoclonal antibodies: effects on Haemaphysalis longicornis tick infestation of BALB/c mice
    Mie Nakajima
    Laboratory of Infectious Diseases, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Jpn J Vet Res 50:157-63. 2003
    ..whether these three isotypes have anti-tick effects and if so which works more effectively, we conducted passive immunization in BALB/c mice with each of the mAbs, and infested the mice with adult ticks...
  49. ncbi Passive immune globulin therapy in the SIV/macaque model: early intervention can alter disease profile
    N L Haigwood
    Department of Immunodeficiency and Immunosuppression, Bristol Myers Squibb Pharmaceutical Research Institute, Seattle, Washington 98121, USA Nancy L
    Immunol Lett 51:107-14. 1996
    ..Reduction of virus burden early in infection by passive IgG can alter disease outcome in SIV infection of macaques. Modifications of this strategy may lead to effective early treatment of HIV-1 infection in humans...
  50. doi Passive immunization against nicotine attenuates somatic nicotine withdrawal syndrome in the rat
    David H Malin
    University of Houston Clear Lake, 2700 Bay Area Blvd, Houston, TX 77058, USA
    Nicotine Tob Res 12:438-44. 2010
    ..Therefore, it was of interest to evaluate the effects of nicotine antibodies on the withdrawal syndrome following termination of chronic nicotine administration...
  51. pmc Passive immunization of channel catfish (Ictalurus punctatus) against the ciliated protozoan parasite Ichthyophthirius multifiliis by use of murine monoclonal antibodies
    T L Lin
    Department of Medical Microbiology, College of Veterinary Medicine, University of Georgia, Athens 30602, USA
    Infect Immun 64:4085-90. 1996
    ..To test this hypothesis, passive immunization experiments were carried out with naive channel catfish, Ictalurus punctatus, using immobilizing murine ..
  52. ncbi Simultaneous active and passive immunization against hepatitis A studied in a population of travellers
    G Wagner
    Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Vaccine 11:1027-32. 1993
    ..We conclude that simultaneous active and passive hepatitis A immunizations can be recommended...
  53. ncbi Secretory immunoglobulin A obtained from pooled human colostrum and milk for oral passive immunization
    Cristiane B Carbonare
    Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Pediatr Allergy Immunol 16:574-81. 2005
    b>Passive immunization is useful in cases of immunodeficiencies or infectious diseases, but usually seric gammaglobulin or hyperimmune sera are administered parenterally, providing good systemic immunization, though with low protection of ..
  54. ncbi Simultaneous effect of gonadotropin-releasing hormone (GnRH) on the expression of two gonadotropin beta genes by passive immunization to GnRH
    Y Kato
    Hormone Assay Center, Gunma University, Japan
    Mol Cell Endocrinol 62:135-9. 1989
    ..hormone (GnRH) on the synthesis of gonadotropins in the pituitary gland of castrated rats, passive immunization to GnRH designed to block the activity of GnRH was performed...
  55. pmc Passive immunization against highly pathogenic Avian Influenza Virus (AIV) strain H7N3 with antiserum generated from viral polypeptides protect poultry birds from lethal viral infection
    Mirza Imran Shahzad
    Department of Biochemistry, Pir Mehr Ali Shah Arid Agriculture University, Murree Rawalpindi, Pakistan
    Virol J 5:144. 2008
    ..Our data provide proof of concept for potential utilization of passive immunization in protecting poultry industry during infection outbreaks...
  56. ncbi Immunoprecipitation and virus neutralization assays demonstrate qualitative differences between protective antibody responses to inactivated hepatitis A vaccine and passive immunization with immune globulin
    S M Lemon
    Department of Medicine, University of North Carolina at Chapel Hill, USA
    J Infect Dis 176:9-19. 1997
    ..5 by RIFIT and 146 by HAVARNA) but negligible precipitating antibody (GMT, 5.6). These results are best explained by differences in the affinity of antibodies for virus following active versus passive immunization.
  57. doi Combined active and passive immunization enhances the efficacy of immunotherapy against nicotine in rats
    SAMUEL A ROIKO
    Minneapolis Medical Research Foundation, Minneapolis, Minnesota, USA
    J Pharmacol Exp Ther 325:985-93. 2008
    ..b>Passive immunization with a nicotine-specific monoclonal antibody (Nic311) has also shown efficacy in rats...
  58. doi Efficacy of passive immunization with IgY antibodies to a 58-kDa H. pylori antigen on severe gastritis in BALB/c mouse model
    Abdelfattah M Attallah
    R and D Department, Biotechnology Research Center, New Damietta City, Egypt
    J Immunoassay Immunochem 30:359-77. 2009
    ..pylori infection was inhibited 1 week after oral passive immunization in 70% of infected BALB/c mice with a significant decrease (p < 0.05) in the degrees of gastritis...
  59. ncbi Passive immunization by lactobacilli expressing single-chain antibodies against Streptococcus mutans
    Carina Krüger
    Division of Clinical Immunology, Karolinska Institutet at Karolinska Huddinge, SE 141 86, Huddinge, Sweden
    Mol Biotechnol 31:221-31. 2005
    ....
  60. ncbi Passive immunization with convalescent serum, or oral immunization with formalin-killed organisms, does not protect mice against gastrointestinal challenge with Listeria monocytogenes
    D C Miller
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, 53706, USA
    Comp Immunol Microbiol Infect Dis 25:69-75. 2002
    ..In this study we found that neither opsonization of L. monocytogenes with immune serum, nor repeated oral administration of killed L. monocytogenes, protected mice against gastrointestinal challenge with L. monocytogenes...
  61. pmc Passive immunization with milk produced from an immunized cow prevents oral recolonization by Streptococcus mutans
    Y Shimazaki
    Department of Preventive Dentistry, Kyushu University Faculty of Dental Science, Fukuoka 812-8582, Japan
    Clin Diagn Lab Immunol 8:1136-9. 2001
    ..These results suggest that milk produced from immunized cow may be useful for controlling S. mutans in the human oral cavity...
  62. pmc Efficient cross-priming of tumor antigen-specific T cells by dendritic cells sensitized with diverse anti-MICA opsonized tumor cells
    Veronika Groh
    Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 102:6461-6. 2005
    ..These results further suggest that antibody targeting of MICA might be applicable to elicit T cell immunity against tumors of diverse tissue origins in cancer patients...
  63. ncbi Effects of passive immunization of goats against inhibin on follicular development, hormone profile and ovulation rate
    M S Medan
    Department of Theriogenology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt
    Reproduction 125:751-7. 2003
    ..that inhibin is an important factor in the regulation of FSH secretion in goats and demonstrate that passive immunization against inhibin at 48 h before treatment with PGF(2alpha) induces the development of more follicles and ..
  64. ncbi Passive immunization protects the mouse eye from damage after herpes simplex virus infection by limiting spread of virus in the nervous system
    C Shimeld
    Department of Ophthalmology, Medical School, University Walk, Bristol
    J Gen Virol 71:681-7. 1990
    ..As expected, without passive immunization, mice developed high levels of serum neutralizing antibody...
  65. pmc Is passive immunization for Alzheimer's disease 'alive and well' or 'dead and buried'?
    Gregory A Jicha
    University of Kentucky College of Medicine, Sanders Brown Center on Aging, Alzheimer s Disease Center, Department of Neurology, 800 South Limestone Street, Lexington, KY 40536 0230, USA
    Expert Opin Biol Ther 9:481-91. 2009
    b>Passive immunization strategies are under investigation as potential disease-modifying therapies for Alzheimer's disease (AD)...
  66. pmc Passive immunization with bovine milk containing antibodies to a cell surface protein antigen-glucosyltransferase fusion protein protects rats against dental caries
    Morihide Mitoma
    Department of Preventive Dentistry, Kyushu University Faculty of Dental Science, Fukuoka 812 8582, Japan
    Infect Immun 70:2721-4. 2002
    ..mutans in a rat model. Concentrated immune milk was fed to rats once a day for 55 days. The group that received immune milk had significantly less caries development than controls...
  67. doi Passive immunization with LINGO-1 polyclonal antiserum afforded neuroprotection and promoted functional recovery in a rat model of spinal cord injury
    Jun Lv
    Department of Neurosurgery, Neurosurgery Institute of Guangdong, Zhujiang Hospital, Southern Medical University, Guangzhou, China
    Neuroimmunomodulation 17:270-8. 2010
    ..The authors report on passive immunization with LINGO-1 polyclonal antiserum, a therapeutic approach to overcome NgR-mediated growth inhibition after ..
  68. ncbi Passive immunization against beta-amyloid peptide protects central nervous system (CNS) neurons from increased vulnerability associated with an Alzheimer's disease-causing mutation
    M Hasan Mohajeri
    Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
    J Biol Chem 277:33012-7. 2002
    ..underscore the possibility that Abeta is toxic, that it increases the vulnerability of neurons to excitotoxic events produced by seizures, and that lowering Abeta by passive immunization can protect neurons from Abeta-related toxicity.
  69. doi Passive immunization with monoclonal antibody against a 70-kDa putative adhesin of Sporothrix schenckii induces protection in murine sporotrichosis
    Rosana C Nascimento
    Departamento de Analises Clinicas e Toxicologicas, Faculdade de Ciencias Farmaceuticas, Universidade de Sao Paulo, Sao Paulo, CEP, Brazil
    Eur J Immunol 38:3080-9. 2008
    ..schenckii in order to better understand the effect of passive immunization of mice infected with S. schenckii...
  70. pmc Passive immunization against poliomyelitis: the Hammon gamma globulin field trials, 1951-1953
    Charles R Rinaldo
    Department of Infectious Diseases, University of Pittsburgh Graduate School of Public Health, School of Public Health, PA 15261, USA
    Am J Public Health 95:790-9. 2005
    ..Graduate School of Public Health led the first major breakthrough in prevention of the disease by using passive immunization in one of the earliest double-blind, placebo-controlled clinical trials...
  71. ncbi Role of antibody to lipopolysaccharide in protection against low- and high-virulence strains of Francisella tularensis
    M Fulop
    Defence Evaluation and Research Agency, CBD, Porton Down, Wiltshire SP4 0JQ, Salisbury, UK
    Vaccine 19:4465-72. 2001
    ..tularensis Schu4. This cohort was significantly protected (LD(50) increased from <1 to >1000 CFU). However, passive transfer of serum did not confer protection and mice depleted of CD4+ or CD8+ T-cells did not survive...
  72. ncbi Passive protection against lethal enterovirus 71 infection in newborn mice by neutralizing antibodies elicited by a synthetic peptide
    Damian Guang Wei Foo
    Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, MD4A, 5 Science Drive 2, Singapore 117597, Singapore
    Microbes Infect 9:1299-306. 2007
    ..In conclusion, EV71-neutralizing antibodies elicited by the synthetic peptide SP70 were able to confer good in vivo passive protection against homologous and heterologous EV71 strains in suckling Balb/c mice...
  73. pmc Targeting of alpha-hemolysin by active or passive immunization decreases severity of USA300 skin infection in a mouse model
    Adam D Kennedy
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Infect Dis 202:1050-8. 2010
    ..b>Passive immunization with Hla-specific antisera or active immunization with a nontoxigenic form of Hla significantly reduced the ..
  74. doi Therapeutic potential of a fully human monoclonal antibody against influenza A virus M2 protein
    Rongfang Wang
    Kirin Pharma USA Inc, La Jolla, CA, USA
    Antiviral Res 80:168-77. 2008
    ..These results suggest the potential of the anti-M2e human MAb with broad binding spectrum as a universal passive immunotherapeutic agent to infection by influenza A virus...
  75. ncbi Anti-TNF antibody treatment reduces mortality in experimental dengue virus infection
    Alena Atrasheuskaya
    State Research Center of Virology and Biotechnology Vector, Novosibirsk Region, Russia
    FEMS Immunol Med Microbiol 35:33-42. 2003
    ..05). Our model supports the view that activation of innate immune response is at least partially responsible for mortality in DEN-2 infection, and in line with this concept, anti-TNF treatment significantly reduces mortality rates...
  76. ncbi Passive antibody therapy for infectious diseases
    Arturo Casadevall
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Nat Rev Microbiol 2:695-703. 2004
    ....
  77. ncbi Protection against H1, H5, H6 and H9 influenza A infection with liposomal matrix 2 epitope vaccines
    William A Ernst
    Molecular Express, Inc 13310 S Figueroa Street, Los Angeles, CA 90061, USA
    Vaccine 24:5158-68. 2006
    ....
  78. ncbi Passive immunization with a human immunodeficiency virus type 1-neutralizing monoclonal antibody in Hu-PBL-SCID mice: isolation of a neutralization escape variant
    L Andrus
    Lindsley F Kimball Research Institute of the New York Blood Center, New York University Medical Center, New York 10021, USA
    J Infect Dis 177:889-97. 1998
    ..32 mg/kg antibody. However, virus isolated from 1 mouse 3 weeks after passive immunization with 13.2 mg/kg antibody proved resistant to subsequent in vitro neutralization by 694/98-D...
  79. ncbi Prevention of virus transmission to macaque monkeys by a vaginally applied monoclonal antibody to HIV-1 gp120
    Ronald S Veazey
    Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana, USA
    Nat Med 9:343-6. 2003
    ..Lower amounts of b12 were less effective, suggesting that protection was dose dependent. These observations support the concept that viral entry inhibitors can help prevent the sexual transmission of HIV-1 to humans...
  80. pmc Passive protection against anthrax by using a high-affinity antitoxin antibody fragment lacking an Fc region
    Robert Mabry
    Department of Chemical Engineering and Biomedical Engineering, University of Texas at Austin, 1 University Station, Austin, TX 78712, USA
    Infect Immun 73:8362-8. 2005
    b>Passive immunization has been successfully employed for protection against bacterial and viral infections for over 100 years...
  81. pmc Determination of a statistically valid neutralization titer in plasma that confers protection against simian-human immunodeficiency virus challenge following passive transfer of high-titered neutralizing antibodies
    Yoshiaki Nishimura
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bldg 4 Rm 315, Bethesda, MD 20892, USA
    J Virol 76:2123-30. 2002
    ..The titer of neutralizing antibodies in the plasma calculated to protect 99% of virus-challenged monkeys was 1:38...
  82. pmc Immunization with parasite-derived apical membrane antigen 1 or passive immunization with a specific monoclonal antibody protects BALB/c mice against lethal Plasmodium yoelii yoelii YM blood-stage infection
    D L Narum
    Division of Parasitology, National Institute for Medical Research, London, NW7 1AA, United Kingdom
    Infect Immun 68:2899-906. 2000
    ..yoelii yoelii AMA-1 were prepared, and one was very effective against the parasite on passive immunization. A second protein that appears to be located in the apical rhoptry organelles and associated with AMA-1 was ..
  83. ncbi Complete protection of neonatal rhesus macaques against oral exposure to pathogenic simian-human immunodeficiency virus by human anti-HIV monoclonal antibodies
    Flavia Ferrantelli
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Infect Dis 189:2167-73. 2004
    ..These data are important for designing clinical trials in human neonates and have general implications for AIDS vaccine development, as the epitopes recognized by the 3 nMAbs are conserved among diverse primary isolates...
  84. pmc Passive immunotherapy in simian immunodeficiency virus-infected macaques accelerates the development of neutralizing antibodies
    Nancy L Haigwood
    Seattle Biomedical Research Institute, 307 Westlake Ave N, Suite 500, Seattle, WA 98109 5219, USA
    J Virol 78:5983-95. 2004
    ..Acceleration of de novo simian immunodeficiency virus immunity in the presence of passively transferred neutralizing antibodies is a novel finding with implications for postexposure prophylaxis and vaccines...
  85. pmc Passive transfer of antibodies protects immunocompetent and imunodeficient mice against lethal Ebola virus infection without complete inhibition of viral replication
    M Gupta
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 75:4649-54. 2001
    ..Thus antibodies suppress or delay viral growth, provide protection against lethal Ebola virus infection, and may not require participation of other immune components for protection...
  86. ncbi Possible benefit of intravenous immunoglobulin therapy in a lung transplant recipient with West Nile virus encephalitis
    A Hamdan
    Internal Medicine B, Rabin Medical Center, Beilinson Campus, Petach Tikva 49100, Israel
    Transpl Infect Dis 4:160-2. 2002
    ..This is the second case of an immunosuppressed patient responding to the same preparation of intravenous immunoglobulins. Larger studies are required in order to establish the therapeutic role of immunoglobulins in patients with WNF...
  87. ncbi Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned?
    M Feldmann
    Kennedy Institute of Rheumatology Division, Imperial College School of Medicine, 1 Aspenlea Road, London W6 8LH, United Kingdom
    Annu Rev Immunol 19:163-96. 2001
    ..Infliximab (a mAB), and etanercept (a sTNF-R-Fc fusion protein) have been approved by regulatory authorities in the United States and Europe for treating RA, and they represent a significant new addition to available therapeutic options...
  88. pmc Post-infection immunodeficiency virus control by neutralizing antibodies
    Hiroyuki Yamamoto
    International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    PLoS ONE 2:e540. 2007
    ..Here, in an attempt to answer this question, we examined the effect of passive NAb immunization post-infection on primary viral replication in a macaque AIDS model...
  89. ncbi Passive immunization with human anti-protein D antibodies induced by polysaccharide protein D conjugates protects chinchillas against otitis media after intranasal challenge with Haemophilus influenzae
    Laura A Novotny
    Columbus Children s Research Institute, Center for Microbial Pathogenesis, The Ohio State University College of Medicine and Public Health, 700 Children s Drive, W591, 43205, USA
    Vaccine 24:4804-11. 2006
    ..6% was shown against acute OM episodes caused by NTHI. These observations strongly support the chinchilla passive transfer-superinfection model as one that could predict clinical trials outcomes for vaccines to prevent NTHI-induced OM...
  90. ncbi Use of intravenous immunoglobulin in human disease: a review of evidence by members of the Primary Immunodeficiency Committee of the American Academy of Allergy, Asthma and Immunology
    Jordan S Orange
    Department of Pediatrics, University of Pennsylvania School of Medicine, The Children s Hospital of Philadelphia, Philadelphia 19104, USA
    J Allergy Clin Immunol 117:S525-53. 2006
    ..Given the potential risks and inherent scarcity of IGIV, careful consideration of the indications for and administration of IGIV is warranted...
  91. pmc Antibodies play a greater role than immune cells in heterologous protection against secondary dengue virus infection in a mouse model
    Jennifer L Kyle
    Division of Infectious Diseases, School of Public Health, University of California, Berkeley, 1 Barker Hall 424, Berkeley, CA 94720 7354, USA
    Virology 380:296-303. 2008
    ..These findings are relevant for understanding both natural and vaccine-induced immunity to DENV...
  92. pmc Protection against development of otitis media induced by nontypeable Haemophilus influenzae by both active and passive immunization in a chinchilla model of virus-bacterium superinfection
    L O Bakaletz
    Division of Otologic Research, Department of Otolaryngology, College of Medicine, The Ohio State University, Columbus, Ohio, USA
    Infect Immun 67:2746-62. 1999
    ..001). Collectively, these data indicate the continued merit of further developing LB1 and LPD-LB1(f)2,1,3 as components of vaccines for otitis media...
  93. pmc Insensitivity of paediatric HIV-1 subtype C viruses to broadly neutralising monoclonal antibodies raised against subtype B
    Elin Solomonovna Gray
    AIDS Virus Research Unit, National Institute for Communicable Diseases, Johannesburg, South Africa
    PLoS Med 3:e255. 2006
    ..To assess the suitability of such an approach, we determined the sensitivity of paediatric HIV-1 subtype C viruses to the broadly neutralising MAbs IgG1b12, 2G12, 2F5, and 4E10...
  94. pmc Passive immunotherapy for influenza A H5N1 virus infection with equine hyperimmune globulin F(ab')2 in mice
    Jiahai Lu
    Sun Yat Sen University, Guangzhou 510080, China
    Respir Res 7:43. 2006
    ....
  95. pmc Antibody prophylaxis and therapy against West Nile virus infection in wild-type and immunodeficient mice
    Michael J Engle
    Departments of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Virol 77:12941-9. 2003
    ..Thus, passive transfer of immune antibody improves clinical outcome even after WNV has disseminated into the central nervous system...
  96. ncbi Evaluation of immune globulin and recombinant interferon-alpha2b for treatment of experimental Ebola virus infections
    P B Jahrling
    United States Army Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702 5011, USA
    J Infect Dis 179:S224-34. 1999
    A passive immunization strategy for treating Ebola virus infections was evaluated using BALB/ c mice, strain 13 guinea pigs, and cynomolgus monkeys...
  97. pmc Antibody prophylaxis and therapy against Nipah virus infection in hamsters
    V Guillaume
    INSERM U 404, CERVI, IFR 128, 21 Avenue Tony Garnier, 69365 Lyon Cedex 07, France
    J Virol 80:1972-8. 2006
    ..Our studies suggest that immunotherapy could be used for people who are exposed to NiV infections...
  98. ncbi Passive immunization with monoclonal IgM antibodies against phosphorylcholine reduces accelerated vein graft atherosclerosis in apolipoprotein E-null mice
    Jose R Faria-Neto
    Atherosclerosis Research Center, Division of Cardiology, Department of Medicine and Burns and Allen Research Institute, Cedars Sinai Medical Center and David Geffen School of Medicine at UCLA, Los Angeles, CA 90048, USA
    Atherosclerosis 189:83-90. 2006
    ..In this study we tested the hypothesis that passive immunization with a monoclonal anti-PC IgM antibody can be athero-protective in a murine model of native aortic and vein ..
  99. ncbi Essential role of neutrophils in the initiation and progression of a murine model of rheumatoid arthritis
    B T Wipke
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 167:1601-8. 2001
    ..These studies have identified a critical role for neutrophils in initiating and maintaining inflammatory processes in the joint...
  100. pmc Protection of wild-type and severe combined immunodeficiency mice against an intranasal challenge by passive immunization with monoclonal antibodies to the Chlamydia trachomatis mouse pneumonitis major outer membrane protein
    Sukumar Pal
    Department of Pathology and Laboratory Medicine, Medical Sciences, Rm D440, University of California, Irvine, Irvine, CA 92697 4800, USA
    Infect Immun 76:5581-7. 2008
    ..MAb MoPn-32 had no neutralizing ability. In comparison to the control normal mouse immunoglobulin G, passive immunization of BALB/c mice with MAb MoPn-23 resulted in a highly significant protection against an intranasal (i.n...
  101. pmc Immune complex-mediated antigen presentation induces tumor immunity
    Khadija Rafiq
    Department of Medicine and Microbiology, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    J Clin Invest 110:71-9. 2002
    ..These data suggest that administration of antitumor antibodies may enhance tumor-specific T cell responses in vivo and provide the rationale for Fc receptor targeting in vaccine development...

Research Grants70

  1. Novel Bioconjugate Vaccines to Prevent Staphylococcus aureus Infection
    JEAN CLAIRE LEE; Fiscal Year: 2013
    ..aureus infection by passive immunization and T cell depletion experiments;(5) development of a GMP compatible production process in E...
  2. INNATE IMMUNE RESPONSE TO MICROBIAL INFECTION
    William M Nauseef; Fiscal Year: 2013
    ..supported by our data demonstrating that an anti-CLM murine monoclonal antibody exerts protection after passive immunization in an experimental infection challenge...
  3. Mechanisms of adaptive immunity to P. aeruginosa in the lung
    Gregory P Priebe; Fiscal Year: 2013
    ..and the mechanisms underlying protection will be evaluated by adoptive transfer experiments combined with passive immunization, by neutralization of IL-17 prior to challenging immunized mice, and by immunization of transgenic mice ..
  4. Antiviral prophylaxis to prevent perinatal transmission of HBV in Thailand
    GONZAGUE JOSEPH JOURDAIN; Fiscal Year: 2013
    ..at birth effectively prevent most transmission from HBV infected mothers but, despite this active and passive immunization, about 12% of HBV highly viremic mothers transmit the virus to their infants...
  5. Mechanism of PsrP mediated adhesion
    Carlos J Orihuela; Fiscal Year: 2013
    ..Antibodies against the BR inhibit bacteria adhesion in vitro and protect mice from challenge following passive immunization. We will determine the segment of BR that is responsible for PsrP-mediated binding...
  6. Hepatitis C: Studies of Immunity and Pathogenesis
    Charles Rice; Fiscal Year: 2009
    ..Tools and reagents developed in the course of these studies will be made available to other HCV CRCs and the broader HCV research community in an effort to speed progress on combating this important public health problem. ..
  7. SPORE in Skin Cancer
    Meenhard Herlyn; Fiscal Year: 2009
    ..CTCL is addressed in one Project and one Pilot Study, and SCC in one Pilot Study. This endeavor represents the synergistic integration of well-established individual research programs towards our collective goals. ..
  8. Infant immunoprophylaxis against a primate lentivirus
    RUTH MARGRIT RUPRECHT; Fiscal Year: 2012
    b>Passive immunization is an important tool to dissect the nature of protective immune responses...
  9. Anti-Autolysin Passive Immunity for MRSA Osteomyelitis
    JOHN LINFORTH DAISS; Fiscal Year: 2010
    ..for this vaccine are immuno-compromised or elderly patients, Codevax LLC has initiated development of a passive immunization that can be given to high-risk patients prior to surgery...
  10. cGMP manufacturing of PBI-220, a broad spectrum immunoadhesin therapeutic against
    LLOYD M YU; Fiscal Year: 2013
    ..90 (Subpart H), which will allow PBI-220 to be supplied to the Strategic National Stockpile as a countermeasure against traditional, enhanced and advanced anthrax strains. ..
  11. Protective Human Monoclonal Antibodies to HIV-1
    SUSAN B ZOLLA-PAZNER; Fiscal Year: 2012
    ..virus replication, and will inform the design of reagents for use in active immunization (vaccines), passive immunization, and immunotherapy...
  12. Phase I Trial with Two HER-2 B Cell Epitope Vaccine in Patients with Solid Tumors
    PRAVIN T P contact KAUMAYA; Fiscal Year: 2010
    ..The advantage of active immunotherapy with safe and non toxic natural synthetic peptides over passive immunotherapy with mAbs such as trastuzumab (Herceptin) is a fundamental aspect of this work. ..
  13. Adenovirus-vectored RSV vaccine not inhibited by maternal immunity
    JASON GRAHAM GALL; Fiscal Year: 2013
    ..In phase I we will test the hypothesis that RSV-specific immune responses induced by a novel replication-deficient adenovirus vector derived from non-human adenovirus will not be inhibited by human viral immunity. ..
  14. Human Rabies Virus Vaccine Development
    James P McGettigan; Fiscal Year: 2012
    ..the number of inoculations from the current standard regimen of five doses of active and one dose of passive immunization to a one- or two-dose immunization protocol. Three Aims are proposed to achieve our overall goal...
  15. Therapeutic Antibodies for CMV
    WILLIAM ROBERT USINGER; Fiscal Year: 2013
    ..b>Passive immunization using human immune globulin (HIG) has been shown to prevent disease...
  16. Final preclinical development of an immunoadhesin therapy for inhalation anthrax
    KEITH WYCOFF; Fiscal Year: 2013
    ....
  17. PROTEINS IN MULTIPLE MYELOMA AND RELATED BLOOD DISORDERS
    Alan Solomon; Fiscal Year: 2011
    ..The ultimate goal of this research is to improve the outcome of patients with AL amyloidosis, a medically devastating and ultimately fatal disease. ..
  18. WGA as a Novel Vehicle for Intranasal Delivery of an Anti-A-beta Antibody in AD
    Neelima B Chauhan; Fiscal Year: 2012
    ..effectively target direct delivery of immunotherapeutics to the brain in order to maximize the efficacy of passive immunization for treating, delaying or preventing Alzheimer's disease (AD), a disease that currently afflicts >5 ..
  19. Immune factors in vaccine-enhanced pandemic H1N1 influenza disease
    Amy L Vincent; Fiscal Year: 2013
    ..meet the objectives by an experimental approach that includes the following specific aims: (1) Determine by passive immunization if antibodies elicited by an inactivated H1 vaccine predispose pigs for enhanced disease when infected with ..
  20. Beta-Amyloid Immunization in a Canine Model of Aging
    Elizabeth Head; Fiscal Year: 2013
    ..Further, learning and memory is improved by either active or passive immunization with anti-A[unreadable] antibodies...
  21. Scavenger Receptors Type-A of Microglia Promote Abeta Uptake After Abeta Immunot
    Donald L Price; Fiscal Year: 2012
    ..entail assessments of biochemical and morphological changes in a transgenic mouse model of AD receiving passive immunization with antibodies against A2. These changes will be correlated with cognitive and behavioral parameters...
  22. IMMUNIZATION TO BLOCK THE EFFECTS OF NICOTINE
    Paul R Pentel; Fiscal Year: 2012
    ..b>Passive immunization with nicotine-specific monoclonal antibodies, an alternative to vaccination, is highly effective in animals ..
  23. Neurologic Alterations in Alzheimer's Disease
    Bradley T Hyman; Fiscal Year: 2010
    ..b>Passive immunization against Abeta, and application of oligomeric Abeta, will be used to test the hypothesis that Abeta is ..
  24. Antigen Specific Response to Borrelia
    Jorge L Benach; Fiscal Year: 2013
    ..At a time when the multiple functions of antibodies are being increasingly recognized and passive immunization is being revived as therapy for infectious and other diseases, the understanding of the versatile nature of ..
  25. Therapeutic Approaches for Prion Disease
    Thomas M Wisniewski; Fiscal Year: 2013
    ..In the prior funding of this grant we reported on the first successful in vivo active and passive immunization approaches for prion diseases using wild-type animals...
  26. Replication-deficient rabies vectors against rabies infection
    James P McGettigan; Fiscal Year: 2012
    ..Current PEPs are comprised of one dose of passive immunization (rabies immune globulin) along with five active immunizations with rabies vaccines...
  27. Amyloid-Lowering Small Molecule AB-Binding Agents in AD
    William E Klunk; Fiscal Year: 2010
    ..and oral efficacy studies of the two most promising agents;3) assessing the cooperativity of SMA?BA and passive immunization treatment;and 4) assessing the absorption, distribution, metabolism and elimination (ADME) and acute ..
  28. The amyloid cascade in a novel mouse model of Alzheimer's disease
    Carol Anne Colton; Fiscal Year: 2013
    ..for Ass peptides in the cascade, we propose a) to reduce Ass levels in the brains of APPSw/NOS2-/- mice by passive immunization and b) to increase Ass levels in the brains of NOS2-/- mice using intrahippocampal injection of Ass peptide ..
  29. Novel therapeutic antibodies for the treatment and prevention of AIDS
    BILL DON HARRIMAN; Fiscal Year: 2012
    ..An innovative approach using a humanized chicken monoclonal antibody to a cryptic epitope on the HIV co- receptor CCR5 is anticipated to yield a candidate that is superior to other CCR5 antibodies in preclinical or clinicl development. ..
  30. Vaccine and therapeutic antibodies against Group A Streptococcus
    Benfang Lei; Fiscal Year: 2013
    ..inhibitory mAbs and test whether inhibitory mAbs protect mice against subcutaneous GAS infection in passive immunization. The project has the potential to lead to the development of a broad vaccine against GAS diseases and an ..
  31. Mechanism of Potent Neutralization of HIV by IgA CD4i Antibody
    Lisa A Cavacini; Fiscal Year: 2013
    ....
  32. Alzheimer's Disease Cooperative Study (ADCS)
    Paul S Aisen; Fiscal Year: 2012
    ..Finally, we will test the ability of passive immunization using Mg which contains natural anti-amyloid antibodies and has been demonstrated to improve cognition in ..
  33. Epitope-Specific Targeting of Tau Aggregates.
    Einar M Sigurdsson; Fiscal Year: 2013
    ..chronic disease such as AD, it can inherently lead to autoimmune adverse reactions that may be avoided with passive immunization. It also remains to be thoroughly assessed if a similar therapeutic effect can be obtained with tau ..
  34. An Immunoprotectant for Marburg Virus
    Larry Zeitlin; Fiscal Year: 2010
    ..b>Passive immunization with antibodies has been shown to be effective against a wide variety of viral, bacterial, fungal, and ..
  35. Passive Immunization for Neurotropic Virus Infection
    DOUGLAS HOOPER; Fiscal Year: 2009
    b>Passive immunization, the administration of pre-formed antigen-specific antibody, provides considerable advantages over active immunization as an immune state can essentially be provided on demand with a lessened chance of an inadequate ..
  36. A Monoclonal Antibody Immunoprotectant for Ebola Virus
    Larry Zeitlin; Fiscal Year: 2013
    ..There are currently no drugs available for preventing or treating Ebola virus infection. Passive immunization with antibodies has been shown to be effective against a wide variety of viruses...
  37. B. anthracis: passive immunization with anticapsular mAb
    Thomas R Kozel; Fiscal Year: 2012
    ..However, targeting the B. anthracis capsule for active or passive immunization will require an understanding of how capsular antibodies mediate protection and an identification of in ..
  38. Spatial and temporal progression of amyloid angiopathy
    Matthew P Frosch; Fiscal Year: 2010
    ..the CAA-induced alterations in vessel wall injury can be interrupted or reversed by clearance of Afi using passive immunization and other methods...
  39. Passive Immunotherapy for Pediatric Mutans Streptococcal Infections
    Martin Taubman; Fiscal Year: 2009
    ..abstract_text> ..
  40. Alpha-Synuclein Isomers as Novel Immunogens for Immunotherapy of Parkinsons Disea
    ROWEN JY CHANG; Fiscal Year: 2010
    ..Successful completion of this project will generate lead aSyn isomers, effective in PD transgenic mouse model, for further development as therapeutic vaccine in treatment of PD. ..
  41. IMMUNOMODULATION BY EXOGENOUS STREPTOCOCCAL ANTIBODY
    L Jeannine Brady; Fiscal Year: 2010
    ..MAbs against it represent an excellent model system to understand the consequences and underlying molecular mechanisms of immunomodulation and would be of general interest for any active or passive immunization approach.
  42. Building novel vaccines on a borrowed coat
    F Nina Papavasiliou; Fiscal Year: 2013
    ..In recent years, passive immunization against non-communicable diseases has also shown great promise...
  43. Role of Neutralizing Antibodies in Transmission of SHIV
    NANCY LOGAN HAIGWOOD; Fiscal Year: 2010
    ..We will isolate human monoclonals that can neutralize HIV-1, and then test these in our nonhuman primate model as immunotherapies to control SHIV infection. ..
  44. Detection and Clearance of AD Lesions
    Thomas M Wisniewski; Fiscal Year: 2013
    ..that is hoped to have a significant impact on disease progression in the near future is active or passive immunization with numerous past and on-going clinical trials...
  45. Passive immunotherapy using plant-derived broadly HIV-1 neutralizing MAbs to prev
    YVONNE J ROSENBERG; Fiscal Year: 2012
    ..In Phase II we shall used an enhanced transient expression system to produce large amounts of new potent MAbs and assess their ability to protect macaques against SHIV virus infection. ..
  46. Knock-in mice expressing germline-reverted broadly neutralizing HIV antibodies
    David Nemazee; Fiscal Year: 2013
    ..Moreover, animal challenge studies after passive immunization have shown that these bNAbs can be protective...
  47. Correlates of protection against SIV/SHIV challenge
    Hildegund C J Ertl; Fiscal Year: 2010
    ..Project 2 will use passive immunization with neutralizing antibodies to determine baseline parameters of antibody-mediated protection with the long-..
  48. The Role of the Inflammasome in Neonatal Sepsis
    JAMES LAWRENCE WYNN; Fiscal Year: 2013
    ....
  49. Neutralizing and non-neutralizing antibodies protection from breast milk HIV-1
    Manish Sagar; Fiscal Year: 2013
    ..In contrast to the passive immunization studies which use supra-physiologic levels of antibodies that can block cell-free challenge virus, infant ..
  50. Human Monoclonal Antibodies that Bind Botulinum Toxins
    SCOTT KENDALL DESSAIN; Fiscal Year: 2013
    ..b>Passive immunization with antibody therapeutics is considered to be the ideal countermeasure for a BoNT exposure, and the safest ..
  51. Vaccine Design to Concentrate Protective Antibodies at the Mucosal Border
    Ashley T Haase; Fiscal Year: 2013
    ..We propose to investigate strategies to reproduce these protective effects by passive immunization with gp41 antibodies, and by immunization with recombinant gp41 immunogens that target Ab to the neonatal ..
  52. Thwarting HIV evasion of antibody avidity with novel antibody architectures
    Pamela J Bjorkman; Fiscal Year: 2012
    ..but we can construct proteins capable of high-avidity trivalent binding to a spike for gene therapy and/or passive immunization. We will design, express, and test trimeric intra-spike cross-linking reagents that bind to two or three ..
  53. Thwarting HIV evasion of antibody avidity with novel antibody architectures
    Pamela J Bjorkman; Fiscal Year: 2013
    ..but we can construct proteins capable of high-avidity trivalent binding to a spike for gene therapy and/or passive immunization. We will design, express, and test trimeric intra-spike cross-linking reagents that bind to two or three ..
  54. Novel anti-bacterial therapy for gram negative pneumonia
    Kanneganti Murthy; Fiscal Year: 2001
    ..Both active and passive immunization strategies that target the N-terminal domain of flagellin reduce mortality in LD9O-100 murine models of ..
  55. Broad-Spectrum Therapeutic Human Antibodies for Dengue Virus Infections
    Yorgo Modis; Fiscal Year: 2006
    ..b>Passive immunization is an accepted medical practice to protect against infection...
  56. AUTOCRINE GROWTH FACTORS--EFFECT OF IMMUNONEUTRALIZATION
    Peter Ravdin; Fiscal Year: 1993
    ..of this proposal is to test the effects on tumor growth and normal physiology of active immunization and passive immunization to transforming growth factor-alpha (TGF-alpha) and epidermal growth factor (EGF)...
  57. SURROGATE ASSAY FOR B19 PARVOVIRUS SERUM NEUTRALIZATION
    GEETHA BANSAL; Fiscal Year: 1990
    ..Plasmapheresis of these individuals will yield plasma pools for hyperimmune globulin production. These anti-B19 virus immunoglobulin preparations will then be clinically evaluated in the treatment of pavoviremia and associated anemias...
  58. Identification of Relaxin Receptor Antagonists
    Sheau Yu Hsu; Fiscal Year: 2005
    ..b>Passive immunization with anti-relaxin antibodies during the anteparmm period reduces cervical growth and extensibility as well ..
  59. Mechanisms of Microglial Activation and Phagocytosis in*
    Gary Landreth; Fiscal Year: 2005
    ..Schenk and colleagues have recently reported that either active or passive immunization of mice with anti-AB antibodies results in the prevention of amyloid deposition as well as the removal of ..
  60. Statins for Alzheimer's disease immunotherapy
    Ken Ichiro Fukuchi; Fiscal Year: 2009
    ..In addition, the clinical trials and passive immunization induced cerebral hemorrhages in one AD patient and some AD mouse models, respectively...
  61. CENTRAL OXYTOCIN STIMULATION OF LHRH AND LH RELEASE
    Craig Johnston; Fiscal Year: 1991
    ..We will examine the ability of passive immunization against OXY or specific OXY antagonists to affect basal and stimulated levels of plasma LH as well as LHRH ..
  62. Second Generation Rabies Vaccines
    James McGettigan; Fiscal Year: 2007
    ..Current PEPs are comprised of one dose of passive immunization (rabies immune globulin) along with five active immunizations with rabies vaccines...
  63. MECHANISMS OF AIRWAY RESPONSES TO ORGANIC DUSTS
    Terry Gordon; Fiscal Year: 1993
    ..Additional experiments will examine whether passive immunization with purified antibodies to these cytokines inhibits the airway effects of inhaled endotoxin...
  64. Human Rabies Virus Vaccine Development
    James McGettigan; Fiscal Year: 2009
    ..Current PEP is comprised of one dose of passive immunization [(rabies immune globulin (RIG)] along with five active immunizations with inactivated rabies vaccines...
  65. Alternative endpoints for plague challenge models
    Richard Frothingham; Fiscal Year: 2005
    ..pestis dose, Y. pestis challenge strain virulence, active or passive immunization, and nonspecific immune stimulation...
  66. High Performance Fluorescence Microscopy Imaging
    RAIMUND OBER; Fiscal Year: 2003
    ..The approach in this proposal is based on recent advances in imaging technology and its applications to cellular biology problems, in particular imaging with single molecule sensitivity. ..
  67. POLYCLONAL ANTIBODY LIBRARIES FOR C PARVUM THERAPY
    Jacqueline Sharon; Fiscal Year: 1999
    ..The IgG, IgA, and sIgA libraries will also be tested for efficacy when administered orally and parenterally to C. parvum- infected mice in a severe combined immunodeficiency (SCID) mouse model of cryptosporidiosis. ..
  68. Efficacy of DNA versus Protein Vaccine
    MYLIEN DAO; Fiscal Year: 2004
    ..to produce recombinant bacteria, protein and peptide vaccines for active immunization, and antibody for passive immunization. Various levels of protection were achieved with these vaccines...
  69. Primate Endometrial Responses to Placental MHC Class I Molecules
    Thaddeus Golos; Fiscal Year: 2009
    ..We have recently demonstrated the biological relevance of primate placental MHC class I expression with passive immunization of rhesus monkeys during early pregnancy...
  70. PROPHOLAXIS OF H. INFLUENZAE AND OTHER INFECTIONS
    Mathuram Santosham; Fiscal Year: 1991
    We have recently completed a study to evaluate the safety and efficacy of passive immunization with a human hyperimmune globulin (BPIG) in preventing Haemophilus influenzae (HI) and other infections...