immunization

Summary

Summary: Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).

Top Publications

  1. pmc Dynamic T cell migration program provides resident memory within intestinal epithelium
    David Masopust
    Department of Microbiology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
    J Exp Med 207:553-64. 2010
  2. ncbi Requirement for CD4 T cell help in generating functional CD8 T cell memory
    Devon J Shedlock
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 300:337-9. 2003
  3. doi CD64 expression distinguishes monocyte-derived and conventional dendritic cells and reveals their distinct role during intramuscular immunization
    Christelle Langlet
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Case 906, 13288 Marseille Cedex 9, France
    J Immunol 188:1751-60. 2012
  4. doi Immunotherapy for Alzheimer's disease: from anti-β-amyloid to tau-based immunization strategies
    Francesco Panza
    Geriatric Unit and Gerontology Geriatric Research Laboratory, IRCCS Casa Sollievo della Sofferenza, Foggia, Italy
    Immunotherapy 4:213-38. 2012
  5. pmc Batf3-dependent CD11b(low/-) peripheral dendritic cells are GM-CSF-independent and are not required for Th cell priming after subcutaneous immunization
    Brian T Edelson
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 6:e25660. 2011
  6. pmc Targeting of alpha-hemolysin by active or passive immunization decreases severity of USA300 skin infection in a mouse model
    Adam D Kennedy
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Infect Dis 202:1050-8. 2010
  7. doi Immunization with HIV-1 gp41 subunit virosomes induces mucosal antibodies protecting nonhuman primates against vaginal SHIV challenges
    Morgane Bomsel
    Mucosal Entry of HIV 1 and Mucosal Immunity, Cell Biology and Host Pathogen Interactions Department, Cochin Institute, CNRS UMR 8104, 22 rue Mechain, Paris, France
    Immunity 34:269-80. 2011
  8. pmc Sequential immunization with a subtype B HIV-1 envelope quasispecies partially mimics the in vivo development of neutralizing antibodies
    Delphine C Malherbe
    Oregon National Primate Center, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    J Virol 85:5262-74. 2011
  9. pmc The feasibility of using mobile-phone based SMS reminders and conditional cash transfers to improve timely immunization in rural Kenya
    Hotenzia Wakadha
    Kenya Medical Research Institute Centers for Disease Control and Prevention Public Health and Research Collaboration, Kisumu, Kenya
    Vaccine 31:987-93. 2013
  10. doi Prevalence of molecular markers of Plasmodium falciparum resistance to sulfadoxine-pyrimethamine during the intermittent preventive treatment in infants coupled with the expanded program immunization in Senegal
    Babacar Faye
    Department of Parasitology, Faculty of de Medicine, Cheikh Anta Diop University of Dakar, Dakar, Senegal
    Parasitol Res 109:133-8. 2011

Detail Information

Publications327 found, 100 shown here

  1. pmc Dynamic T cell migration program provides resident memory within intestinal epithelium
    David Masopust
    Department of Microbiology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
    J Exp Med 207:553-64. 2010
    ..This paradigm is difficult to reconcile with reports of intestinal T cell responses after alternative routes of immunization. We reconcile this discrepancy by demonstrating that activation within spleen results in intermediate induction ..
  2. ncbi Requirement for CD4 T cell help in generating functional CD8 T cell memory
    Devon J Shedlock
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 300:337-9. 2003
    ..These results demonstrate a previously undescribed role for CD4 help in the development of functional CD8 memory...
  3. doi CD64 expression distinguishes monocyte-derived and conventional dendritic cells and reveals their distinct role during intramuscular immunization
    Christelle Langlet
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Case 906, 13288 Marseille Cedex 9, France
    J Immunol 188:1751-60. 2012
    ..Therefore, a full understanding of the role of adjuvants during i.m. vaccination needs to take into account the heterogeneous migratory and functional behavior of muscle DCs and Mo-DCs revealed in this study...
  4. doi Immunotherapy for Alzheimer's disease: from anti-β-amyloid to tau-based immunization strategies
    Francesco Panza
    Geriatric Unit and Gerontology Geriatric Research Laboratory, IRCCS Casa Sollievo della Sofferenza, Foggia, Italy
    Immunotherapy 4:213-38. 2012
    ..Although some studies suggested that active immunization may be effective against tau in animal models of AD, very few studies regarding passive immunization against ..
  5. pmc Batf3-dependent CD11b(low/-) peripheral dendritic cells are GM-CSF-independent and are not required for Th cell priming after subcutaneous immunization
    Brian T Edelson
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 6:e25660. 2011
    ..Further, Batf3(-/-) mice lacking all peripheral CD11b(low/-) DCs show robust Th cell priming after subcutaneous immunization and are susceptible to EAE...
  6. pmc Targeting of alpha-hemolysin by active or passive immunization decreases severity of USA300 skin infection in a mouse model
    Adam D Kennedy
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Infect Dis 202:1050-8. 2010
    ..Passive immunization with Hla-specific antisera or active immunization with a nontoxigenic form of Hla significantly reduced the ..
  7. doi Immunization with HIV-1 gp41 subunit virosomes induces mucosal antibodies protecting nonhuman primates against vaginal SHIV challenges
    Morgane Bomsel
    Mucosal Entry of HIV 1 and Mucosal Immunity, Cell Biology and Host Pathogen Interactions Department, Cochin Institute, CNRS UMR 8104, 22 rue Mechain, Paris, France
    Immunity 34:269-80. 2011
    ..The protection observed challenges the paradigm whereby circulating antiviral antibodies are required for protection against HIV-1 infection and may serve in designing a human vaccine against HIV-1-AIDS...
  8. pmc Sequential immunization with a subtype B HIV-1 envelope quasispecies partially mimics the in vivo development of neutralizing antibodies
    Delphine C Malherbe
    Oregon National Primate Center, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    J Virol 85:5262-74. 2011
    ....
  9. pmc The feasibility of using mobile-phone based SMS reminders and conditional cash transfers to improve timely immunization in rural Kenya
    Hotenzia Wakadha
    Kenya Medical Research Institute Centers for Disease Control and Prevention Public Health and Research Collaboration, Kisumu, Kenya
    Vaccine 31:987-93. 2013
    ..We studied the feasibility of using short message services (SMS) reminders and mobile phone-based conditional cash transfers (CCTs) to reach parents in rural Western Kenya...
  10. doi Prevalence of molecular markers of Plasmodium falciparum resistance to sulfadoxine-pyrimethamine during the intermittent preventive treatment in infants coupled with the expanded program immunization in Senegal
    Babacar Faye
    Department of Parasitology, Faculty of de Medicine, Cheikh Anta Diop University of Dakar, Dakar, Senegal
    Parasitol Res 109:133-8. 2011
    ..preventive treatment (IPT) using sulfadoxine-pyrimethamine (SP) coupled with the expanded program of immunization (EPI) in infants. However, its adoption as a strategy is conditioned by the long-term efficacy of SP...
  11. ncbi Collagen-induced arthritis
    David D Brand
    Research Service, Veterans Affairs Medical Center, Memphis, Tennessee 38104, USA
    Nat Protoc 2:1269-75. 2007
    ..Autoimmune arthritis is induced in this model by immunization with an emulsion of complete Freund's adjuvant and type II collagen (CII)...
  12. doi Long-term protection against malaria after experimental sporozoite inoculation: an open-label follow-up study
    Meta Roestenberg
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
    Lancet 377:1770-6. 2011
    ..This immunity was associated with parasite-specific production of interferon γ and interleukin 2 by pluripotent effector memory cells in vitro. We aim to explore the persistence of protection and immune responses in the same volunteers...
  13. pmc Defective CD8 T cell memory following acute infection without CD4 T cell help
    Joseph C Sun
    Department of Immunology and the Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    Science 300:339-42. 2003
    ..The results highlight a previously undescribed role for CD4 help in promoting protective CD8 memory development...
  14. pmc Vaccination with a synthetic peptide from the influenza virus hemagglutinin provides protection against distinct viral subtypes
    Taia T Wang
    Department of Microbiology and Medicine, Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 107:18979-84. 2010
    Current influenza virus vaccines protect mostly against homologous virus strains; thus, regular immunization with updated vaccine formulations is necessary to guard against the virus' hallmark remodeling of regions that mediate ..
  15. pmc A novel monoclonal anti-CD81 antibody produced by genetic immunization efficiently inhibits Hepatitis C virus cell-cell transmission
    Isabel Fofana
    INSERM, U1110, Institute of Virology, Strasbourg, France
    PLoS ONE 8:e64221. 2013
    ..Viral entry is required for initiation, spread, and maintenance of infection, making it an attractive target for antiviral strategies...
  16. pmc Different B cell populations mediate early and late memory during an endogenous immune response
    Kathryn A Pape
    Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Science 331:1203-7. 2011
    ..Using an antigen-based technique to enrich these cells, we found that immunization with a model protein generated B memory cells that expressed isotype-switched immunoglobulins (swIg) or ..
  17. doi Immunization status and risk factors of migrant children in densely populated areas of Beijing, China
    Meiping Sun
    Institute of Immunization and Prevention, Beijing Center for Disease Control and Prevention, Beijing, China
    Vaccine 28:1264-74. 2010
    To properly evaluate the immunization status and determine risk factors of migrant children in 23 densely populated towns and townships in Beijing.
  18. doi Immunization with Porphyromonas gingivalis enolase induces autoimmunity to mammalian α-enolase and arthritis in DR4-IE-transgenic mice
    Andrew J Kinloch
    Kennedy Institute of Rheumatology, Imperial College London, London, UK
    Arthritis Rheum 63:3818-23. 2011
    ..To examine the hypothesis that the subset of rheumatoid arthritis (RA) characterized by antibodies to citrullinated α-enolase is mediated by Porphyromonas gingivalis enolase in the context of DR4 alleles...
  19. pmc Sublingual immunization with M2-based vaccine induces broad protective immunity against influenza
    Byoung Shik Shim
    Laboratory Science Division, International Vaccine Institute, Seoul, Republic of Korea
    PLoS ONE 6:e27953. 2011
    ..The mechanism whereby s.l. immunization with M2e vaccine candidate induces broad protection against infection with different influenza virus subtypes ..
  20. pmc Tau-targeted immunization impedes progression of neurofibrillary histopathology in aged P301L tau transgenic mice
    Mian Bi
    Laboratory for Translational Neurodegeneration, Brain and Mind Research Institute, The University of Sydney, Camperdown, New South Wales, Australia
    PLoS ONE 6:e26860. 2011
    ..Unfortunately, the currently available therapies are limited to symptomatic relief. While active immunization against Aβ has shown efficacy in both various AD mouse models and patients with AD, immunization against ..
  21. pmc Sex-specific immunization for sexually transmitted infections such as human papillomavirus: insights from mathematical models
    Johannes A Bogaards
    Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands
    PLoS Med 8:e1001147. 2011
    ..Here, we address the question of whether vaccinating females only, males only, or both sexes is the most effective strategy to reduce the population prevalence of an STI like HPV...
  22. pmc Local response to microneedle-based influenza immunization in the skin
    Maria del Pilar Martin
    Department of Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, USA
    MBio 3:e00012-12. 2012
    ..We demonstrate correlation of immunization against influenza virus with a local increase of cytokines important for recruitment of neutrophils, monocytes ..
  23. ncbi Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells
    Chandrashekhar Pasare
    Howard Hughes Medical Institute and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 299:1033-6. 2003
    ..This block of suppressor activity was dependent in part on interleukin-6, which was induced by TLRs upon recognition of microbial products...
  24. doi Prime and boost immunization with influenza and adenovirus encoding the Toxoplasma gondii surface antigen 2 (SAG2) induces strong protective immunity
    Alexandre V Machado
    Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270 910, MG, Brazil
    Vaccine 28:3247-56. 2010
    ..gondii, they displayed up to 85% of reduction in parasite burden. These results demonstrate the potential use of recombinant influenza vectors harboring the dicistronic segments in the development of vaccines against infectious diseases...
  25. pmc Immunization status and sociodemographic characteristics: the mediating role of beliefs, attitudes, and perceived control
    R Prislin
    Department of Psychology, San Diego State University, CA 91182 4611, USA
    Am J Public Health 88:1821-6. 1998
    This study examined how immunization-related beliefs, attitudes, and perceived control mediate up-to-date immunization among various sociodemographic groups.
  26. doi The effect of enterovirus 71 immunization on neuropathogenesis and protein expression profiles in the thalamus of infected rhesus neonates
    Huicheng Chen
    Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming, Yunnan 650118, PR China
    Virology 432:417-26. 2012
    ..Changes in protein expression profiles following immunization with the inactivated EV71 vaccine followed by virus challenge were observed and evaluated, and their ..
  27. doi Treg suppress CTL responses upon immunization with HSP gp96
    Zhen Liu
    CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences CAS, Beijing, PR China
    Eur J Immunol 39:3110-20. 2009
    ..In this study, we monitored the activities of T cells and activation of Treg in BABL/c mice after immunization using different doses of gp96 as adjuvant...
  28. pmc Induction of antibodies in rhesus macaques that recognize a fusion-intermediate conformation of HIV-1 gp41
    S Moses Dennison
    Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, United States of America
    PLoS ONE 6:e27824. 2011
    ..This Env-liposome immunization strategy induced antibodies to the 2F5 neutralizing epitope ⁶⁶⁴DKW residues, and these antibodies ..
  29. doi Burden of invasive pneumococcal disease and serotype distribution among Streptococcus pneumoniae isolates in young children in Europe: impact of the 7-valent pneumococcal conjugate vaccine and considerations for future conjugate vaccines
    Daniel J Isaacman
    Global Medical Affairs, Vaccines, Wyeth Pharmaceuticals Inc, Collegeville, PA, USA
    Int J Infect Dis 14:e197-209. 2010
    ..The overall reported burden of invasive pneumococcal disease (IPD) varies among countries in Europe. This review describes the epidemiology and serotype distribution of IPD in European children from studies published from 1990 to 2008...
  30. pmc The effect of universal influenza immunization on mortality and health care use
    Jeffrey C Kwong
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    PLoS Med 5:e211. 2008
    In 2000, Ontario, Canada, initiated a universal influenza immunization program (UIIP) to provide free influenza vaccines for the entire population aged 6 mo or older...
  31. ncbi T cells as mediators of protective immunity against liver stages of Plasmodium
    Moriya Tsuji
    Department of Medical and Molecular Parasitology, New York University School of Medicine, 341 East 25th Street, New York, NY 10010, USA
    Trends Parasitol 19:88-93. 2003
    ..These T cells inhibit parasite development in the liver, and immunization with subunit vaccines expressing the respective antigenic moieties confers protection against sporozoite ..
  32. doi Protection of macaques against vaginal SHIV challenge by systemic or mucosal and systemic vaccinations with HIV-envelope
    Susan W Barnett
    Novartis Vaccines and Diagnostics, Inc, 4560 Horton Street, Emeryville, California 94608, USA
    AIDS 22:339-48. 2008
    ..Worldwide, the majority of human immunodeficiency virus (HIV) infections occur by heterosexual transmission. Thus, the development of a vaccine that can prevent intravaginal HIV infection is an important goal of AIDS vaccine research...
  33. pmc Immunization of pigs to prevent disease in humans: construction and protective efficacy of a Salmonella enterica serovar Typhimurium live negative-marker vaccine
    Martin Selke
    Institute for Microbiology, Department of Infectious Diseases, University of Veterinary Medicine Hannover, Hannover, Germany
    Infect Immun 75:2476-83. 2007
    ..The approach described overcomes the problems currently limiting the use of bacterial live vaccines and holds considerable potential for future developments in the field...
  34. doi Universal HIV testing of infants at immunization clinics: an acceptable and feasible approach for early infant diagnosis in high HIV prevalence settings
    Nigel Rollins
    Department of Paediatrics and Child Health, University of KwaZulu Natal, Durban, South Africa
    AIDS 23:1851-7. 2009
    To determine the acceptability and feasibility of universal HIV testing of 6-week-old infants attending immunization clinics to achieve early diagnosis of HIV and referral for HIV treatment and care services.
  35. pmc Therapeutic effects of immunization with mutant superoxide dismutase in mice models of amyotrophic lateral sclerosis
    Makoto Urushitani
    Department of Anatomy and Physiology, Laval University Research Centre, Centre hospitalier de l Universite Laval, 2705 Boulevard Laurier, Quebec QC G1V 4G2, Canada
    Proc Natl Acad Sci U S A 104:2495-500. 2007
    ..This evidence led us to test immunization protocols aiming to reduce the burden of extracellular SOD1 mutants in nervous tissue of mice models of ALS, by ..
  36. pmc The membrane-proximal external region of the human immunodeficiency virus type 1 envelope: dominant site of antibody neutralization and target for vaccine design
    Marinieve Montero
    Department of Molecular Biology and Chemistry, Simon Fraser University, 8888 University Drive, Burnaby V5A 1S6, British Columbia, Canada
    Microbiol Mol Biol Rev 72:54-84, table of contents. 2008
    ..In addition, emerging approaches to vaccine design are presented...
  37. ncbi Efficient immunization strategies for computer networks and populations
    Reuven Cohen
    Minerva Center and Department of Physics, Bar Ilan University, Ramat Gan, 52900, Israel
    Phys Rev Lett 91:247901. 2003
    We present an effective immunization strategy for computer networks and populations with broad and, in particular, scale-free degree distributions...
  38. pmc Neutralizing antibodies to HIV-1 induced by immunization
    Laura E McCoy
    Wohl Virion Centre, Division of Infection and Immunity, University College London, London WC1E 6BT, England, UK
    J Exp Med 210:209-23. 2013
    ..Considerable hurdles remain for inducing neutralizing antibodies to a protective level after immunization. Meanwhile, novel technologies to bypass the induction of antibodies are being explored to provide prophylactic ..
  39. pmc Active and passive immunization protects against lethal, extreme drug resistant-Acinetobacter baumannii infection
    Guanpingshen Luo
    Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor University of California Los Angeles UCLA Medical Center, Torrance, California, United States of America
    PLoS ONE 7:e29446. 2012
    ..baumannii. These results define active and passive immunization strategies to prevent and treat highly lethal, XDR A. baumannii infections.
  40. pmc Lentiviral vectors transduce proliferating dendritic cell precursors leading to persistent antigen presentation and immunization
    Frederick Arce
    Division of Infection and Immunity, University College London, London, UK
    Mol Ther 17:1643-50. 2009
    ..These results show that LVs transduce DC precursors, which maintain transduced DCs in spleen for at least 2 months, leading to prolonged antigen presentation and effective T-cell memory...
  41. pmc Decline in diarrhea mortality and admissions after routine childhood rotavirus immunization in Brazil: a time-series analysis
    Greice Madeleine Ikeda do Carmo
    Secretariat for Health Surveillance Secretaria de Vigilância em Saúde, Ministry of Health, Brasilia, Brazil
    PLoS Med 8:e1001024. 2011
    In 2006, Brazil began routine immunization of infants <15 wk of age with a single-strain rotavirus vaccine...
  42. pmc Preservation of the immunogenicity of dry-powder influenza H5N1 whole inactivated virus vaccine at elevated storage temperatures
    Felix Geeraedts
    Department of Medical Microbiology, Molecular Virology Section, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    AAPS J 12:215-22. 2010
    ..Use of the more stable dry-powder formulation could simplify stockpiling and thereby facilitating successful pandemic intervention...
  43. pmc Efficient generation of mucosal and systemic antigen-specific CD8+ T-cell responses following pulmonary DNA immunization
    Maytal Bivas-Benita
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    J Virol 84:5764-74. 2010
    ..m.) immunization. Most importantly, we observed that the pulmonary delivery of PEI-DNA elicited a 10-fold-greater antigen-..
  44. pmc Establishment of a bovine herpesvirus 4 based vector expressing a secreted form of the bovine viral diarrhoea virus structural glycoprotein E2 for immunization purposes
    Gaetano Donofrio
    Universita di Parma, Facolta di Medicina Veterinaria, Dipartimento di Salute Animale, Sezione di Malattie Infettive degli Animali, Via del Taglio 8, 43100 Parma, Italy
    BMC Biotechnol 7:68. 2007
    ....
  45. ncbi Factors affecting acceptance of complete immunization coverage of children under five years in rural Bangladesh
    Mosiur Rahman
    Department of Population Science and Human Resource Development, University of Rajshahi, Rajshahi, Bangladesh
    Salud Publica Mex 52:134-40. 2010
    ..This article establishes the hypothesis that predisposing, enabling and household needs influence the complete vaccination status of children...
  46. pmc TLR3- and MyD88-dependent signaling differentially influences the development of West Nile virus-specific B cell responses in mice following immunization with RepliVAX WN, a single-cycle flavivirus vaccine candidate
    Jingya Xia
    Department of Microbiology and Immunology, University of Texas Medical Branch UTMB, Galveston, Texas, USA
    J Virol 87:12090-101. 2013
    ..signaling are involved in the intrinsic adjuvanting of RepliVAX WN and differentially contribute to the development of vigorous WNV-specific antibody and B cell memory responses following immunization with this novel SCFV vaccine.
  47. doi Accuracy and quality of immunization information systems in forty-one low income countries
    Xavier Bosch-Capblanch
    Swiss Centre for International Health Swiss Tropical Institute, Basel, Switzerland
    Trop Med Int Health 14:2-10. 2009
    To measure the accuracy and quality of immunization information systems in a range of low-income countries eligible to receive GAVI support.
  48. doi Feasibility of a randomized controlled trial to evaluate Text Reminders for Immunization Compliance in Kids (TRICKs)
    Carolyn R Ahlers-Schmidt
    University of Kansas School of Medicine Wichita, Department of Pediatrics, Wichita, KS 67214, United States
    Vaccine 30:5305-9. 2012
    To pilot test the Text Reminders for Immunization Compliance in Kids (TRICKs) program to evaluate its feasibility and potential to increase immunization coverage.
  49. pmc Mixed vector immunization with recombinant adenovirus and MVA can improve vaccine efficacy while decreasing antivector immunity
    Arturo Reyes-Sandoval
    The Jenner Institute, University of Oxford, Oxford, UK
    Mol Ther 20:1633-47. 2012
    ..Mixed vector immunization led to increased early circulating interferon-γ (IFN-γ) response levels and altered transcriptional ..
  50. ncbi Epidermal langerhans cells are dispensable for humoral and cell-mediated immunity elicited by gene gun immunization
    Angelika Stoecklinger
    Christian Doppler Laboratory of Allergy Diagnostics and Therapy, Department of Molecular Biology, University Salzburg, Salzburg, Austria
    J Immunol 179:886-93. 2007
    Gene gun immunization, i.e., bombardment of skin with DNA-coated particles, is an efficient method for the administration of DNA vaccines...
  51. doi Advances in transcutaneous vaccine delivery: do all ways lead to Rome?
    Suzanne M Bal
    Division of Drug Delivery Technology, Leiden Amsterdam Center for Drug Research, Leiden, The Netherlands
    J Control Release 148:266-82. 2010
    Transcutaneous immunization (TCI) is a promising alternative to vaccine delivery via the subcutaneous and intramuscular routes, due to the unique immunological characteristics of the skin...
  52. pmc The impact of helminths on the response to immunization and on the incidence of infection and disease in childhood in Uganda: design of a randomized, double-blind, placebo-controlled, factorial trial of deworming interventions delivered in pregnancy and e
    Alison M Elliott
    Uganda Virus Research Institute, Entebbe, Uganda
    Clin Trials 4:42-57. 2007
    ..These effects might develop in utero, through exposure to maternal helminth infections, or through direct exposure in later life...
  53. ncbi IL-12 enhances protective immunity in mice engendered by immunization with recombinant 14 kDa Schistosoma mansoni fatty acid-binding protein through an IFN-gamma and TNF-alpha dependent pathway
    Cristina T Fonseca
    Department of Biochemistry and Immunology, Institute for Investigation in Immunology Millenium Institute, Federal University of Minas Gerais, Av Antonio Carlos 6627, Pampulha, 30161970 Belo Horizonte, MG, Brazil
    Vaccine 22:503-10. 2004
    Herein, we tested the ability of IL-12 to enhance protection induced by recombinant Sm14 (rSm14). Mice immunization with three doses of 25 microg of rSm14 was able to induce 25% of protection in mice against challenge...
  54. ncbi Sublingual immunization induces broad-based systemic and mucosal immune responses in mice
    Nicolas Cuburu
    Institut National de la Sante et de la Recherche Medicale INSERM, Unité Mixte de Recherche UMR 721, Universite de Nice Sophia Antipolis, Nice, France
    Vaccine 25:8598-610. 2007
    ..l. DCs after topical application of cholera toxin (CT) adjuvant under the tongue. S.l. immunization with ovalbumin and CT induced vigorous systemic and mucosal antibody responses...
  55. ncbi Maintenance of serological memory by polyclonal activation of human memory B cells
    Nadia L Bernasconi
    Institute for Research in Biomedicine, Via Vela 6, CH 6500 Bellinzona, Switzerland
    Science 298:2199-202. 2002
    ..Although antigen boosting leads to a transient increase in specific antibody levels, ongoing polyclonal activation of memory B cells offers a means to maintain serological memory for a human lifetime...
  56. ncbi Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease
    Eliezer Masliah
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    Neuron 46:857-68. 2005
    ..Since previous studies suggest that immunization might be a potential therapy for Alzheimer's disease, we hypothesized that immunization with human (h)alpha-syn ..
  57. pmc The ability of an oligomeric human immunodeficiency virus type 1 (HIV-1) envelope antigen to elicit neutralizing antibodies against primary HIV-1 isolates is improved following partial deletion of the second hypervariable region
    S W Barnett
    Chiron Corporation, Emeryville, California 94608-2916, USA
    J Virol 75:5526-40. 2001
    ....
  58. ncbi Parental beliefs and decision making about child and adolescent immunization: from polio to sexually transmitted infections
    Lynne A Sturm
    Riley Child Development Center, School of Medicine, Indiana University, Indianapolis 46202 5200, USA
    J Dev Behav Pediatr 26:441-52. 2005
    Over the past 150 years, innovations in immunization practices have dramatically improved the health of children, and parents are increasingly asked to consider and accept new childhood vaccines...
  59. ncbi Immunization without needles
    Samir Mitragotri
    Department of Chemical Engineering, University of California, Santa Barbara, California 93106, USA
    Nat Rev Immunol 5:905-16. 2005
    Most current immunization procedures make use of needles and syringes for vaccine administration...
  60. pmc Humoral immune response to mixed PfAMA1 alleles; multivalent PfAMA1 vaccines induce broad specificity
    Kwadwo A Kusi
    Department of Parasitology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    PLoS ONE 4:e8110. 2009
    ..This explains the broadened cross inhibition of diverse malaria parasites, and suggests multi-allele approaches warrant further clinical investigation...
  61. pmc Toll-like receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates
    Ulrike Wille-Reece
    Cellular Immunology Section, Vaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:1249-58. 2006
    ..Gag protein/Montanide and CpG ODN or the TLR7/8 agonist had higher frequencies of Th1 responses after primary immunization compared to all other vaccine groups...
  62. pmc Cytokines as adjuvants for the induction of anti-human immunodeficiency virus peptide immunoglobulin G (IgG) and IgA antibodies in serum and mucosal secretions after nasal immunization
    Curtis P Bradney
    Department of Medicine, Human Vaccine Institute, Center for AIDS Research, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Virol 76:517-24. 2002
    ..Nasal immunization of BALB/c mice with 10 microg of an HIV env peptide immunogen with IL-1alpha, IL-12, and IL-18 on days 0, 7, 14,..
  63. pmc Therapeutic immunization with HIV-1 Tat reduces immune activation and loss of regulatory T-cells and improves immune function in subjects on HAART
    Barbara Ensoli
    National AIDS Center, Istituto Superiore di Sanita, Rome, Italy
    PLoS ONE 5:e13540. 2010
    ..individuals enrolled in a phase II randomized open-label multicentric clinical trial of therapeutic immunization with Tat (ISS T-002)...
  64. pmc Comparison of the oral, rectal, and vaginal immunization routes for induction of antibodies in rectal and genital tract secretions of women
    P A Kozlowski
    Department of Pediatrics, Harvard Medical School, Children s Hospital, Boston, Massachusetts 02115, USA
    Infect Immun 65:1387-94. 1997
    To determine which mucosal immunization routes may be optimal for induction of antibodies in the rectum and female genital tract, groups of women were immunized a total of three times either orally, rectally, or vaginally with a cholera ..
  65. pmc New candidate vaccines against blood-stage Plasmodium falciparum malaria: prime-boost immunization regimens incorporating human and simian adenoviral vectors and poxviral vectors expressing an optimized antigen based on merozoite surface protein 1
    Anna L Goodman
    The Jenner Institute, University of Oxford, Oxford, United Kingdom
    Infect Immun 78:4601-12. 2010
    ..falciparum. These vectored vaccines should allow assessment in humans of the safety and efficacy of inducing strong cellular as well as cross-strain humoral immunity to P. falciparum MSP-1...
  66. doi Intranasal immunization promotes th17 immune responses
    Beata M Zygmunt
    Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    J Immunol 183:6933-8. 2009
    ..In this study, we demonstrated that intranasal (i.n.) immunization leads per se to Th17-biased immune responses, regardless of the adjuvant used...
  67. doi Integration of immunization services with other health interventions in the developing world: what works and why? Systematic literature review
    A Wallace
    Global Immunization Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Trop Med Int Health 14:11-9. 2009
    To assess benefits, challenges and characteristics of integrating child and maternal health services with immunization programmes.
  68. pmc Immunization by influenza virus-like particles protects aged mice against lethal influenza virus challenge
    Zhiyuan Wen
    National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, People s Republic of China
    Antiviral Res 84:215-24. 2009
    ..b>Immunization with influenza VLPs induced strong antibody responses against HA that inhibited hemagglutination by influenza ..
  69. pmc Complete protection against severe acute respiratory syndrome coronavirus-mediated lethal respiratory disease in aged mice by immunization with a mouse-adapted virus lacking E protein
    Craig Fett
    Department of Microbiology, University of Iowa, Iowa City, Iowa, USA
    J Virol 87:6551-9. 2013
    ..rMA15-ΔE is safe, causing no disease in 6-week-, 12-month-, or 18-month-old BALB/c mice. Immunization with this virus completely protected mice of three ages from lethal disease and effected more-rapid virus ..
  70. pmc A bibliometric analysis of childhood immunization research productivity in Africa since the onset of the Expanded Program on Immunization in 1974
    Charles S Wiysonge
    Vaccines for Africa Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Anzio Road Observatory, Cape Town 7925, South Africa
    BMC Med 11:66. 2013
    The implementation of strategic immunization plans whose development is informed by available locally-relevant research evidence should improve immunization coverage and prevent disease, disability and death in Africa...
  71. ncbi Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
    F Bard
    Elan Pharmaceuticals, 800 Gateway Boulevard, South San Francisco, California 94080, USA
    Nat Med 6:916-9. 2000
    ..Active immunization of PDAPP mice with human amyloid beta-peptide reduces plaque burden and its associated pathologies...
  72. pmc Adverse effect of nano-silicon dioxide on lung function of rats with or without ovalbumin immunization
    Bing Han
    Laboratory of Environmental Sciences and Hubei Key Laboratory of Genetic Regulation and Integrative Biology, Huazhong Normal University, Wuhan, China
    PLoS ONE 6:e17236. 2011
    ..For the first time, this work investigates the relationship between allergic asthma and nanosized silicon dioxide (nano-SiO₂)...
  73. pmc Linkages between maternal education and childhood immunization in India
    Kriti Vikram
    Department of Sociology, 2112 Art Sociology Building, University of Maryland, College Park, MD 20742, United States
    Soc Sci Med 75:331-9. 2012
    ..this analysis examines four possible pathways that may mediate the influence of maternal education on childhood immunization: greater human, social, and cultural capitals and more autonomy within the household...
  74. pmc Antibody-mediated protection against mucosal simian-human immunodeficiency virus challenge of macaques immunized with alphavirus replicon particles and boosted with trimeric envelope glycoprotein in MF59 adjuvant
    Susan W Barnett
    Novartis Vaccines and Diagnostics, 350 Massachusetts Avenue, Cambridge, MA 02139, USA
    J Virol 84:5975-85. 2010
    ..high-dose intravenous challenge with simian-human immunodeficiency virus SHIV(SF162P4) following sequential immunization with alphavirus replicon particles (VRP) of a chimeric recombinant VEE/SIN alphavirus (derived from Venezuelan ..
  75. pmc Long term protection after immunization with P. berghei sporozoites correlates with sustained IFNγ responses of hepatic CD8+ memory T cells
    Krystelle Nganou-Makamdop
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 7:e36508. 2012
    Protection against P. berghei malaria can successfully be induced in mice by immunization with both radiation attenuated sporozoites (RAS) arresting early during liver stage development, or sporozoites combined with chloroquine ..
  76. doi Transcutaneous immunization using a dissolving microneedle array protects against tetanus, diphtheria, malaria, and influenza
    Kazuhiko Matsuo
    Laboratory of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0781, Japan
    J Control Release 160:495-501. 2012
    Transcutaneous immunization (TCI) is an attractive alternative vaccination route compared to the commonly used injection systems...
  77. doi Mucosal immunization with recombinant influenza hemagglutinin protein and poly gamma-glutamate/chitosan nanoparticles induces protection against highly pathogenic influenza A virus
    Ho Jin Moon
    College of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea
    Vet Microbiol 160:277-89. 2012
    ..Intranasal immunization with mixture of rHA antigen or inactivated virus and γ-PGA/chitosan nanoparticles (PC NPs) induced not only a ..
  78. doi Reduced Plasmodium berghei sporozoite liver load associates with low protective efficacy after intradermal immunization
    K Nganou-Makamdop
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Parasite Immunol 34:562-9. 2012
    ..We investigated in a murine model the protective efficacy and immune responses after ID or IV immunization of sporozoites...
  79. pmc Intranasal immunization with nontypeable Haemophilus influenzae outer membrane vesicles induces cross-protective immunity in mice
    Sandro Roier
    Institute of Molecular Biosciences, University of Graz, Graz, Austria
    PLoS ONE 7:e42664. 2012
    ..the immunogenic and protective properties of OMVs derived from various NTHi strains by means of nasopharyngeal immunization and colonization studies with BALB/c mice...
  80. doi Systemic flagellin immunization stimulates mucosal CD103+ dendritic cells and drives Foxp3+ regulatory T cell and IgA responses in the mesenteric lymph node
    Adriana Flores-Langarica
    Medical Research Council Centre for Immune Regulation, Division of Immunity and Infection, Institute of Biomedical Research, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Immunol 189:5745-54. 2012
    Mucosal immunity is poorly activated after systemic immunization with protein Ags...
  81. pmc Trends in child immunization across geographical regions in India: focus on urban-rural and gender differentials
    Prashant Kumar Singh
    International Institute for Population Sciences, Mumbai, India
    PLoS ONE 8:e73102. 2013
    Although child immunization is regarded as a highly cost-effective lifesaver, about fifty percent of the eligible children aged 12-23 months in India are without essential immunization coverage...
  82. doi Immunization of macaques with soluble HIV type 1 and influenza virus envelope glycoproteins results in a similarly rapid contraction of peripheral B-cell responses after boosting
    Christopher Sundling
    Department of Microbiology, Karolinska Institutet, Stockholm, Sweden
    J Infect Dis 207:426-31. 2013
    ..However, immunization with soluble Env was reported to induce short-lived antibody responses, suggesting that Env has unusual ..
  83. doi Immunization with DNA topoisomerase I and Freund's complete adjuvant induces skin and lung fibrosis and autoimmunity via interleukin-6 signaling
    Ayumi Yoshizaki
    Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Arthritis Rheum 63:3575-85. 2011
    ..However, the role of induction of anti-topo I antibody production and its potential contribution to the pathogenesis of SSc remain unclear. The aim of this study was to examine the role of anti-topo I antibody in the pathogenesis of SSc...
  84. ncbi Quantitative and mechanistic studies of Abeta immunotherapy
    Todd E Golde
    Mayo Clinic, College of Medicine, Department of Neuroscience, Mayo Clinic Florida, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
    CNS Neurol Disord Drug Targets 8:31-49. 2009
    ..We will conclude with a discussion of additional experimentation required to better understand the mechanism of action of anti-Abeta Abs in AD and optimize antibody (Ab) mediated therapy for AD...
  85. doi Microarray of allergenic component-based diagnosis in food allergy
    Maria L Sanz
    Departamento de Alergología e Inmunología Clínica, Clinica Universidad de Navarra, Pamplona, Spain
    Curr Opin Allergy Clin Immunol 11:204-9. 2011
    ..In this review, we will analyze the results obtained to date with this technology applied to the component-based diagnosis of food allergy...
  86. pmc Development and characterization of monoclonal antibodies against Rift Valley fever virus nucleocapsid protein generated by DNA immunization
    Raquel Martín-Folgar
    Centro de Investigacion en Sanidad Animal, Carretera de Valdeolmos, Valdeolmos, Madrid, Spain
    MAbs 2:275-84. 2010
    ..Monoclonal antibodies (mAbs) were generated after DNA immunization of Balb/c mice and characterized by western blot, ELISA and cell immunostaining assays...
  87. doi Autoreactive antibodies and loss of retinal ganglion cells in rats induced by immunization with ocular antigens
    Panagiotis Laspas
    Experimental Ophthalmology, Department of Ophthalmology, University Medical Center, Johannes Gutenberg University, Mainz, Germany
    Invest Ophthalmol Vis Sci 52:8835-48. 2011
    In an experimental autoimmune animal model, retinal ganglion cell (RGC) loss was induced through immunization with glaucoma-related antigens...
  88. doi Greater viral rebound and reduced time to resume antiretroviral therapy after therapeutic immunization with the ALVAC-HIV vaccine (vCP1452)
    Brigitte Autran
    UPMC Univ Paris 06, UMR_543, France
    AIDS 22:1313-22. 2008
    Evaluate immunogenicity and clinical efficacy of two immunization strategies with the ALVAC-HIV-recombinant canarypox vaccine (vCP1452) in treated HIV-infected patients.
  89. ncbi Generation of anti-Neu-glycolyl-ganglioside antibodies by immunization with an anti-idiotype monoclonal antibody: A self versus non-self-matter
    Ana Maria Hernandez
    Department of Antibody Engineering, Center of Molecular Immunology, P O Box 16040, Havana 11600, Cuba
    Immunobiology 210:11-21. 2005
    ..Here we report that the antibody response against NeuGc-containing gangliosides induced by immunization with 1E10 mAb was completely different in both species...
  90. ncbi Intranasal immunization with phosphorylcholine induces antigen specific mucosal and systemic immune responses in mice
    Norimitsu Tanaka
    Department of Otolaryngology, Head and Neck Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Vaccine 25:2680-7. 2007
    ..Salivary IgA antibodies produced by intranasal immunization with PC-KLH plus CT reacted to most strains of S. pneumoniae and H. influenzae...
  91. pmc Novel surface display system for proteins on non-genetically modified gram-positive bacteria
    Tjibbe Bosma
    BiOMaDe Technology, Nijenborgh 4, 9747 AG Groningen, The Netherlands
    Appl Environ Microbiol 72:880-9. 2006
    ..The versatility and flexibility of the display and delivery technology were demonstrated by investigating enzyme immobilization and nasal vaccine applications...
  92. ncbi Inactivation of the viral interleukin 1beta receptor improves CD8+ T-cell memory responses elicited upon immunization with modified vaccinia virus Ankara
    Caroline Staib
    GSF Institute of Molecular Virology and Institute of Virology, Technical University of Munich, Trogerstrasse 4b, 81675 Munchen, Germany
    J Gen Virol 86:1997-2006. 2005
    ..These data suggest that deletion of the viral IL1betaR gene may be considered a relevant approach to amplify the virus-specific CD8+ memory T-cell response and duration of protective immunity obtained after MVA vaccination...
  93. doi CD11c provides an effective immunotarget for the generation of both CD4 and CD8 T cell responses
    Fernanda V V Castro
    Tenovus Research Laboratory, Cancer Sciences Division, Southampton University School of Medicine, Southampton, UK
    Eur J Immunol 38:2263-73. 2008
    ..These results suggest that targeting antigen via CD11c offers a previously unappreciated strategy for vaccine development which, unlike most targets, delivers robust responses of both CD4 and CD8 T cells...
  94. doi The future of immunisation policy, implementation, and financing
    Orin S Levine
    Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Lancet 378:439-48. 2011
    ..Novel methods are needed to finance the increasing number of new vaccines that have the potential to save lives in countries that are too poor to afford them. Here, we discuss some options...
  95. doi Combination of lentivector immunization and low-dose chemotherapy or PD-1/PD-L1 blocking primes self-reactive T cells and induces anti-tumor immunity
    Sophie R Sierro
    Ludwig Center for Cancer Research of the University of Lausanne, Epalinges, Switzerland
    Eur J Immunol 41:2217-28. 2011
    ..Association of active immunization with chemotherapy or antibodies that block inhibitory pathways often leads to better anti-tumor effects...
  96. pmc Llama antibody fragments recognizing various epitopes of the CD4bs neutralize a broad range of HIV-1 subtypes A, B and C
    Nika Strokappe
    Biomolecular Imaging, Department Biology, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    PLoS ONE 7:e33298. 2012
    ..of trimeric forms of envelope proteins (Env), derived from HIV-1 of subtype A and B/C, for a prolonged immunization of two llamas. A panel of VHH, which interfere with CD4 binding to HIV-1 Env were selected with use of panning...
  97. pmc Immunization of mice with recombinant protein CobB or AsnC confers protection against Brucella abortus infection
    Simei Fu
    Department of Infectious Disease Control, Institute of Disease Control and Prevention, Academy of Military Medical Science, Beijing, China
    PLoS ONE 7:e29552. 2012
    ..Altogether, the present study showed that CobB or AsnC protein could be useful antigen candidates for the development of subunit vaccines against brucellosis with adequate immunogenicity and protection efficacy...
  98. pmc Impact of Schistosoma japonicum infection on collagen-induced arthritis in DBA/1 mice: a murine model of human rheumatoid arthritis
    Xiaorong Song
    Institute of Clinical Pharmacology, Anhui Medical University, Hefei, Anhui, China
    PLoS ONE 6:e23453. 2011
    ..The hygiene hypothesis suggests that helminth infections prevent a range of autoimmune diseases...
  99. ncbi Reduction of anti-HIV-1 Gag immune responses during co-immunization: immune interference by the HIV-1 envelope
    Franklin R Toapanta
    Center for Vaccine Research and Department of Medicine, Division of Infectious Diseases, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Curr HIV Res 5:199-209. 2007
    b>Immunization with more than one immunogen (co-immunization) is an efficient regimen to induce immunity to multiple antigens. However, immune interference has been reported using multi-plasmid DNA immunizations...
  100. doi Immunisation route-dependent expression of IL-4/IL-13 can modulate HIV-specific CD8(+) CTL avidity
    Charani Ranasinghe
    The Australian National University, Canberra, Australia
    Eur J Immunol 39:1819-30. 2009
    ..STAT6(-/-) mice also showed memory CTL of higher avidity. Furthermore, CCL5 expression in K(d)Gag(197-205)-specific CTL was also regulated by IL-4/IL-13...
  101. pmc Comparative immunogenicity in rhesus monkeys of DNA plasmid, recombinant vaccinia virus, and replication-defective adenovirus vectors expressing a human immunodeficiency virus type 1 gag gene
    Danilo R Casimiro
    Department of Viral Vaccine Research, Merck and Company, West Point, Pennsylvania 19486, USA
    J Virol 77:6305-13. 2003
    ..immune responses, monkeys were exposed to adenovirus subtype 5 that did not encode antigen prior to immunization with Ad5-gag. The resulting anti-Gag T-cell responses were attenuated but not abolished...

Research Grants75

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..Design: - Before the start of the study, participants will be screened with a medical history, immunization records, a series of eye examinations, a chest X-ray, an electrocardiogram, and blood tests...
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..Design: - Before the start of the study, participants will be screened with a medical history, immunization records, a series of eye examinations, a chest X-ray, an electrocardiogram, and blood tests...
  3. Identification of Genetic and Epigenetic Alterations in Spondyloarthritis
    Tibor T Glant; Fiscal Year: 2013
    ..PG]-induced spondyloarthritis (PGISpA), which develops in genetically homogeneous inbred BALB/c mice upon immunization with cartilage PG, is permissive to genetic manipulation...
  4. Natural History and Prevention of Viral Hepatitis Among Alaska Natives
    BRIAN JAMES MCMAHON; Fiscal Year: 2013
    ..4] [5] Much like the hepatitis A vaccine, hepatitis B immunization strategies for infants, children, adolescents and adults have significantly decreased the incidence and ..
  5. Mucosal Immunity, Vaccines and Microbiota Interplay in Humans and Animal
    Marcelo B Sztein; Fiscal Year: 2013
    ..immunity comes from studies in adults, we will also focus some efforts in exploring the responses to oral immunization with the licensed Ty21a typhoid in children and, for the first time, the elderly...
  6. Nanopolymersomes for Transcutaneous Co-Delivery of Vaccine Antigens and Adjuvants
    PAUL CAMILLE TUMEH; Fiscal Year: 2013
    ..NPS)-based vaccine delivery system that will topically co- deliver antigen/adjuvant for transcutaneous immunization (TCI)...
  7. Novel DNA-Launched Attenuated Vaccine for VEE Virus
    PETER M PUSHKO; Fiscal Year: 2012
    ..the "infectious DNA" (i-DNA) vaccination technology, which represents a unique combination of conventional DNA immunization with high efficacy of live attenuated vaccines...
  8. Bi-functional Therapeutics for Allergy-BFTA
    Swey Shen Chen; Fiscal Year: 2010
    ..We will evaluate whether duration of anti-C(2-3L antibody responses following the last immunization of the PIT regimen via mucosal vs. systemic route may be within one to three months'protective window...
  9. Recombinant Attenuated Salmonella Vaccines for Humans
    Roy Curtiss; Fiscal Year: 2012
    ..Paratyphi A to deliver multiple hepatitis B virus (HBV) antigens for oral immunization of newborns and infants to prevent HBV transmission during childbirth. We will also develop a RASV using S...
  10. Development of Vaccines against Clostridium difficile Infection
    SAUL R TZIPORI; Fiscal Year: 2013
    ..antibody responses against a wide-spectrum of epitopes and potent protective immunity superior to toxoid;cTxAB immunization induced antibody and protective responses against both TcdA and TcdB...
  11. Novel Bioconjugate Vaccines to Prevent Staphylococcus aureus Infection
    JEAN CLAIRE LEE; Fiscal Year: 2013
    ..assays to evaluate the functionality of antibodies elicited by the bioconjugate vaccines;(3) perform active immunization experiments to test the efficacy of the multi-component bioconjugate vaccine in rodent models of staphylococcal ..
  12. VACCINE INDUCED IMMUNITY IN THE YOUNG AND AGED
    Rafi Ahmed; Fiscal Year: 2013
    ..made substantial progress in characterizing human memory T and B cell responses not only to YFV but also after immunization with small pox and influenza vaccines...
  13. MAPPING OF ARTHRITIS SUSCEPTIBILITY GENES
    Tibor T Glant; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Systemic immunization of BALB/c mice with human cartilage proteoglycan (PG) aggrecan induces progressive polyarthritis...
  14. Nanoemulsion-based vaccine for chronic hepatitis B virus
    James R Baker; Fiscal Year: 2010
    ..Therefore, current immunization strategies for hepatitis B cannot be employed as therapeutic vaccines...
  15. Vitamin A adjuvant to enhance gut immunity and rotavirus vaccines in neonates
    Linda J Saif; Fiscal Year: 2010
    ..WHO has linked vitamin A (VitA) supplementation in infants to immunization programs to reduce VAD and increase vaccine coverage...
  16. Epidemiology and Etiology of Hospitalized Pneumonia in Children
    Krow Ampofo; Fiscal Year: 2010
    ..Epidemiology and Etiology of Hospitalized Pneumonia in Children, supports and addresses the National Center for Immunization and Respiratory Diseases (NCIRD) of CDC objectives of "Healthy People 2010" to prevent disease, disability, and ..
  17. Immune Development: Role of Milk Cell Transfer and Recipient Gender
    Ameae M Walker; Fiscal Year: 2013
    ..development in general, b) to sexual dimorphism both in susceptibility to immune disease and the efficacy of immunization, and c) to the possibility of safely enhancing immunity in young children...
  18. Vaccine Assembly from Surface Proteins of Staphylococcus Aureus
    Olaf Schneewind; Fiscal Year: 2013
    ..aureus strains as antigens in a murine model of abscess formation. Immunization with surface proteins, including the heme-transport proteins IsdA and IsdB, generated significant protective ..
  19. Evolution of the Immune Response to Cytomegalovirus Transmitted via Breast Milk
    Lynn Puddington; Fiscal Year: 2010
    ..infants are asymptomatic, it has been proposed that this route of infection could represent a type of natural immunization. The effectiveness of exposure to the virus through breastfeeding in the ability of the neonate to develop ..
  20. NOX1 and NOX2 as Therapeutic Targets in Influenza
    JOHN DAVID LAMBETH; Fiscal Year: 2013
    ..provided by the applicant): Influenza virus shows high rates of mutation and recombination that soon renders immunization ineffective and requires yearly production of vaccines...
  21. Mucosal Immunity and Influenza Vaccines: Phenotype and Role of Activated B Cells
    HARRY BERNARD GREENBERG; Fiscal Year: 2010
    ..Characterize the trafficking receptor profiles of activated IgA and IgG B cells (plasmablasts) after immunization with LAIV or TIV...
  22. Mechanism of Translation Elongation Factor 2 Inhibition by Bacterial Toxins
    Terri Goss Kinzy; Fiscal Year: 2010
    ..Developing countries still experience outbreaks of Diphtheria, concerns regarding re-immunization and continued protection against C. diphtheriae are emerging, and P...
  23. INNATE IMMUNE RESPONSE TO MICROBIAL INFECTION
    William M Nauseef; Fiscal Year: 2013
    ..supported by our data demonstrating that an anti-CLM murine monoclonal antibody exerts protection after passive immunization in an experimental infection challenge...
  24. ANIMAL MODELS OF HYPERTHYROIDISM
    Sandra M McLachlan; Fiscal Year: 2012
    ..Shed A-subunits drive immunity leading to thyroid stimulating antibodies and hyperthyroidism. Immunization using an adenovirus (Ad) engineered to express the A-subunit is an effective approach to induce thyroid ..
  25. Mechanisms of adaptive immunity to P. aeruginosa in the lung
    Gregory P Priebe; Fiscal Year: 2013
    ..We have shown that nasal immunization with live-attenuated aroA deletion mutants of P...
  26. Development of a Recombinant Tetravalent Dengue Vaccine Based on a Subunit Envelo
    Lynda G Tussey; Fiscal Year: 2013
    ..While interference can be overcome by a 12-month immunization schedule, this schedule renders the vaccine unsuitable for recipients requiring rapid development of immunity...
  27. Yale Autoimmunity Center of Excellence
    Kevan C Herold; Fiscal Year: 2013
    ..Two clinical trials are proposed based on preclinical and mechanistic studies. The first is a Phase I trial of immunization of patients with Type 1 diabetes with a fusion molecule containing antigen epitopes thought to be involved in ..
  28. Carbohydrate-based Antiinfective Agents
    Chi Huey Wong; Fiscal Year: 2013
    ..Strategies for inhibition and immunization need to be improved, as high rates of viral mutation lead to resistance against antiinfluenza agents (e.g...
  29. Host Defense Mechanisms in Polyaromatic Hydrogen Carcinogenesis
    Craig A Elmets; Fiscal Year: 2013
    ..To test our hypothesis, we have prepared a genetic-immunization vector containing a ubiquitin-mutant ras fusion minigene sequence which provides superior proteosome targeting ..
  30. Hepatocarcinogenesis Secondary to Hepatitis C
    Srikanta Dash; Fiscal Year: 2012
    ..This research proposal intends to develop intracellular immunization strategy to inhibit HCV...
  31. NICHD Maternal Fetal Medicine Units Network
    Geeta K Swamy; Fiscal Year: 2013
    ..includes prematurity, premature rupture of membranes, fetal growth restriction, racial disparities, maternal immunization, and maternal medical conditions - particularly thrombosis and hemostasis...
  32. Combination Clostridium Difficile Toxin and Adhesin Vaccine
    Ciaran P Kelly; Fiscal Year: 2013
    ..Since C difficile isa mucosal pathogen, several routes of immunization that target the mucosal surface such as intra- rectal, intranasal and transcutaneous will be compared to ..
  33. Autoimmunity in the Mediation of Infectious Myocarditis
    Jay Reddy; Fiscal Year: 2013
    ..responses, MHC class II dextramer staining, cytokine analysis, magnetic resonance microscopy imaging, active immunization and adoptive transfer experiments, and histology...
  34. Developing Immunotherapeutics for Methamphetamine Abuse
    THOMAS RICHARD KOSTEN; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Immunization against methamphetamine (MA) is potentially valuable in assisting patients in stopping their abuse...
  35. Programming of Protective CD8 T-Cell Memory by Live and Adjuvanted Subunit Vaccin
    Marulasiddappa Suresh; Fiscal Year: 2013
    ..currently used adjuvanted inactivated/subunit vaccines largely elicit humoral immunity, often require repeated immunization to maintain protective levels of immunity, and typically stimulate poor CD8 T cell responses...
  36. Preclinical studies of a heroin/morphine vaccine for opiate addiction
    Paul R Pentel; Fiscal Year: 2013
    ..by antibody relates to vaccine efficacy, and will provide biomarkers that can be used to asses the adequacy of immunization in future clinical trials...
  37. Development of an effective genital herpes vaccine
    William P Halford; Fiscal Year: 2010
    ..Likewise, mice in which an HSV-2 ICP0- virus replicates at the site of immunization are immune to lethal challenge with HSV-2 MS...
  38. Protective orthopox immunization in normals and patients with cancer or eczema
    Ellis Reinherz; Fiscal Year: 2009
    ..An Educational Component, Pilot Project Component and Research Resource Technical Development Component are proposed for rapid dissemination of methods and reagents resulting from this Center's effort. ..
  39. Molecular and Cellular Mechanisms of IL-17 Signaling
    Xiaoxia Li; Fiscal Year: 2013
    ..oligodendrocytes and neurons) resulted in significantly reduced EAE severity whether EAE was induced by active immunization or adoptive transfer of myelin-specific Th17 cells...
  40. Rho-Modifying Cytotoxic Necrotizing Factor of E. coli
    ALISON DAVIS O'BRIEN; Fiscal Year: 2013
    ..attempt to reduce the extent of inflammation and damage evoked by CP9 through parenteral and/or mucosal immunization of mice with a CNF1/Hly toxoid cocktail.
  41. Development of a Univalent Vaccine Against Group B Streptococci Infection
    Stephen K Hunter; Fiscal Year: 2010
    ..the National Academy of Sciences indicated that a GBS vaccine is an important goal because "a program of active immunization aimed at pregnant women would have the best prospects of controlling early-onset and late-onset disease...
  42. Novel Bacillus subtilis based spore vaccine to tuberculosis
    Subramanian Dhandayuthapani; Fiscal Year: 2013
    ..then test the spores for their ability to eliit anti-Mtb cellular immune responses, after intranasal or oral immunization of the mice...
  43. Microneedle-based immunization against pandemic influenza
    Mark R Prausnitz; Fiscal Year: 2011
    ..These studies will produce microneedles designed to meet the needs of mass immunization against pandemic influenza...
  44. Modeling distinct neonatal purine metabolism to inform vaccine development
    Ofer Levy; Fiscal Year: 2013
    ..Characterization of the underlying mechanisms may identify novel approaches to neonatal immunization. We have shown that neonatal blood plasma has higher concentrations of adenosine (Ado), an endogenous purine ..
  45. Antiviral prophylaxis to prevent perinatal transmission of HBV in Thailand
    GONZAGUE JOSEPH JOURDAIN; Fiscal Year: 2013
    ..About 7% of Thai adults are HBsAg carriers. Universal immunization programs have dramatically reduced the prevalence of infection wherever they have been implemented...
  46. Experimental Molecular Vaccines for Schistosomiasis
    Afzal A Siddiqui; Fiscal Year: 2012
    ..Furthermore, immunization with various formulations of Sm-p80 has resulted in a significant level of protective immunity in mice ..
  47. Combination Clostridium Difficile Toxin and Adhesin Vaccine
    Ciaran P Kelly; Fiscal Year: 2011
    ..Since C difficile is a mucosal pathogen, several routes of immunization that target the mucosal surface such as intrarectal, intranasal and transcutaneous will be compared to ..
  48. Vaccines for Sustainable Therapy of Opiate Addiction
    Frank M Orson; Fiscal Year: 2012
    ..An especially attractive alternative approach against opiate addiction in this context is immunization, a potentially powerful tool in assisting individuals to stop their abuse of these substances...
  49. Immune Regulation of CNS Viral Recrudescence
    Cornelia Bergmann; Fiscal Year: 2010
    ..b>Immunization with a tracer Ag will monitor recruitment and retention of 'bystander'ASC to the CNS following viral ..
  50. SEX EFFECTS ON CHEMOKINE MEDIATED CNS AUTOIMMUNITY
    Lillian Cruz-Orengo; Fiscal Year: 2012
    ..determined that the naive female SJL mouse, which may be induced to develop relapsing-remitting EAE via active immunization, exhibits lumenal CXCL12 expression within the white matter microvasculature, while the naove male SJL mouse, ..
  51. Immunomodulation in melanoma therapy
    NOAH A CRAFT; Fiscal Year: 2012
    ..Preliminary data suggests that the TLR7 agonist, imiquimod, is an effective adjuvant to immunization with recombinant Listeria monocytogenes (rLM) expressing melanoma antigens...
  52. A. L. lactis-based vaccine for children with broad spectrum for enteric pathogens
    Wendy L Picking; Fiscal Year: 2013
    ..In Aim 3 we will examine their protective efficacy using optimized immunization schedules and different challenge models...
  53. Recombinant life attenuated vaccine against Argentine hemorrhagic fever
    Slobodan Paessler; Fiscal Year: 2013
    ..For this, we will determine clinical parameters associated with immunization of rCandid1cSD including: body temperature and weight, overall activity, assessment of hematological and ..
  54. Cookstove Replacement for Prevention of ARI and Low Birthweight in Nepal
    JAMES MACK TIELSCH; Fiscal Year: 2012
    ..Besides immunization there is little evidence for effective primary preventive approaches for ARI on a population basis...
  55. Role of T Cell Mediated Immunity In Emotion And Stress Responsiveness
    Leonardo H Tonelli; Fiscal Year: 2012
    ..Control groups will consist of naive RAG2-/- mice under different immunization protocols and reconstituted RAG2-/- mice not immunized (not activated)...
  56. Development of a novel vaccine against congenital cytomegalovirus infection
    Christopher S Morello; Fiscal Year: 2010
    ..To this end, we have recently shown that DNA immunization using either of two conserved, essential genes of MCMV (the DNA polymerase M54 and the helicase M105) protects ..
  57. Mechanism of PsrP mediated adhesion
    Carlos J Orihuela; Fiscal Year: 2013
    ..Antibodies against the BR inhibit bacteria adhesion in vitro and protect mice from challenge following passive immunization. We will determine the segment of BR that is responsible for PsrP-mediated binding...
  58. Genetic Analysis of Mosquito Metamorphosis
    James T Nishiura; Fiscal Year: 2012
    ..Current methods to control these diseases emphasize immunization, chemical prophylaxis, control of the insect vectors, and reduced contact with insect vectors...
  59. E2-Cellular Complexes in HPV Chromatin Transcription
    Cheng Ming Chiang; Fiscal Year: 2013
    ..Although two prophylactic vaccines against HPV infection are presently available and recommended for immunization of young girls/boys, therapeutic vaccines that are most needed for the majority of HPV-infected populations are ..
  60. Gutless Adenovirus Mediated Gene Therapy for Glioma
    Maria G Castro; Fiscal Year: 2011
    ..Harnessing the host's immune system to develop novel treatments for GBM has been attempted. Systemic immunization against glioma has not yielded beneficial effects, since it is limited by progressive tumor mutation, and a ..
  61. Effects of Maternal Influenza Immunization: A Field Trial in Guatemala'
    Saad B Omer; Fiscal Year: 2010
    ..The potential impact of maternal influenza immunization on maternal and infant outcomes has important clinical and public health implications...
  62. Targeting the oral cavity epithelium for inducing mucosal immunity against HIV
    Harvinder Singh Gill; Fiscal Year: 2012
    ..achieve high antigen stability and delivery efficiency and (ii) to compare OC and intramuscular (IM) routes of immunization in rabbits using well characterized HIV antigens with focus on anti-HIV antibodies in the saliva, and at other ..
  63. GENETIC ANALYSIS OF LUPUS AUTOIMMUNITY
    Judith James; Fiscal Year: 2000
    ..James has shown that certain strains of inbred mice also respond to Sm peptide immunization with epitope spreading and genesis of autoantibodies to other parts of the Sm and nRNP autoantigens, as well as ..
  64. DISSEMINATED TUBERCULOSIS IN HIV INFECTION
    C von Reyn; Fiscal Year: 2004
    ..Mycobacterial immunization in early HIV infection is a potential strategy to prevent dMTB...
  65. REGULATION OF IMMUNE RESPONSE IN THE ORAL CAVITY
    Suzanne Michalek; Fiscal Year: 2003
    ..The purpose of the present studies is to establish the effectiveness of the intranasal (IN) route of immunization for inducing human salivary IgA responses protective against infection with S. mutans...
  66. Statins for Alzheimer's disease immunotherapy
    Ken Ichiro Fukuchi; Fiscal Year: 2009
    ..b>Immunization of AD mouse models with synthetic Ab prevented or reduced Ab deposits and improved their memory and learning ..
  67. VIRAL HEPATITIS IN CHILDREN OF INJECTION DRUG USERS
    Kathleen Schwarz; Fiscal Year: 2003
    ..Although both poverty and the condition of being homeless are associated with low immunization rates, strategies to improve immunization for HBV in CIDU have not been systematically studied, and the ..
  68. INFECTION, IMMUNIZATION AND HOST POPULATION DYNAMICS
    A John; Fiscal Year: 1993
    Every year, more than four million children are killed or disabled by diseases that can be prevented by immunization. In the proposed research project, the dynamics of childhood infectious diseases in populations with completely specified ..
  69. AUTOCRINE GROWTH FACTORS--EFFECT OF IMMUNONEUTRALIZATION
    Peter Ravdin; Fiscal Year: 1993
    The objective of this proposal is to test the effects on tumor growth and normal physiology of active immunization and passive immunization to transforming growth factor-alpha (TGF-alpha) and epidermal growth factor (EGF)...
  70. NATURAL AND INDUCED IMMUNITY AGAINST HELICOBACTER PYLORI
    Pierre Michetti; Fiscal Year: 2000
    ..In contrast, oral immunization in mice and ferrets with various H...
  71. Potency of cryopreserved, irradiated sporozoite vaccine
    Stephen Hoffman; Fiscal Year: 2005
    ..In limited trials, this type of immunization has been shown to protect greater than 90% of human volunteers against experimental P...
  72. WGA as a Novel Vehicle for Intranasal Delivery of an Anti-A-beta Antibody in AD
    Neelima B Chauhan; Fiscal Year: 2012
    ..target direct delivery of immunotherapeutics to the brain in order to maximize the efficacy of passive immunization for treating, delaying or preventing Alzheimer's disease (AD), a disease that currently afflicts >5 ..
  73. Evaluation of vaccination reminder/recall systems for adolescent patients
    Allison Kempe; Fiscal Year: 2009
    ..levels for infants and younger children, little is known about the effectiveness of such systems for increasing immunization rates in adolescent populations...
  74. BROADLY EFFECTIVE NEUTRALIZATION AND CTL AGAINST HIV 1
    Gerald Quinnan; Fiscal Year: 2003
    We plan to test the hypothesis that immunization regimens optimized for the induction of potent, broadly cross-reactive neutralizing antibodies and cytotoxic T cells (CTL) can confer protective immunity against multiple clades of HIV-1...
  75. NATURAL AND INDUCED IMMUNITY AGAINST HELICOBACTER PYLORI
    Pierre Michetti; Fiscal Year: 2001
    ..In contrast, oral immunization in mice and ferrets with various H...