histocompatibility testing

Summary

Summary: Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)

Top Publications

  1. pmc Next-generation sequencing for HLA typing of class I loci
    Rachel L Erlich
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
    BMC Genomics 12:42. 2011
  2. ncbi HLA DNA typing: past, present, and future
    H Erlich
    Roche Molecular Systems, Inc, Pleasanton, CA, USA
    Tissue Antigens 80:1-11. 2012
  3. ncbi High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation
    Stephanie J Lee
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Blood 110:4576-83. 2007
  4. pmc High-resolution, high-throughput HLA genotyping by next-generation sequencing
    G Bentley
    Department of Human Genetics, Roche Molecular Systems Inc, Pleasanton, CA 94588, USA
    Tissue Antigens 74:393-403. 2009
  5. ncbi Next-generation sequencing: the solution for high-resolution, unambiguous human leukocyte antigen typing
    C Lind
    Department of Pathology and Laboratory Medicine, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Hum Immunol 71:1033-42. 2010
  6. ncbi Rapid high-throughput human leukocyte antigen typing by massively parallel pyrosequencing for high-resolution allele identification
    Christian Gabriel
    Red Cross Transfusion Service of Upper Austria, Krankenhausstrasse 7, 4017 Linz, Austria
    Hum Immunol 70:960-4. 2009
  7. ncbi Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome
    Neal Flomenberg
    Department of Medicine and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Blood 104:1923-30. 2004
  8. ncbi Common and well-documented HLA alleles: report of the Ad-Hoc committee of the american society for histocompatiblity and immunogenetics
    Pedro Cano
    University of Texas M D Anderson Cancer Center, HLA Typing Laboratory, Houston, Texas 77054, USA
    Hum Immunol 68:392-417. 2007
  9. ncbi Clinical relevance of pretransplant donor-specific HLA antibodies detected by single-antigen flow-beads
    Patrizia Amico
    Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland
    Transplantation 87:1681-8. 2009
  10. pmc Sequence capture and next generation resequencing of the MHC region highlights potential transplantation determinants in HLA identical haematopoietic stem cell transplantation
    Johannes Pröll
    Red Cross Transfusion Service for Upper Austria, Linz
    DNA Res 18:201-10. 2011

Detail Information

Publications322 found, 100 shown here

  1. pmc Next-generation sequencing for HLA typing of class I loci
    Rachel L Erlich
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
    BMC Genomics 12:42. 2011
    ..We have coupled this process to a novel HLA calling algorithm to determine the most likely pair of alleles at each locus...
  2. ncbi HLA DNA typing: past, present, and future
    H Erlich
    Roche Molecular Systems, Inc, Pleasanton, CA, USA
    Tissue Antigens 80:1-11. 2012
    ..Here, our lab's efforts to develop high-resolution and high-throughput HLA DNA typing using the 454 Sequencing System are reviewed, and the potential future developments and applications of HLA DNA typing are discussed...
  3. ncbi High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation
    Stephanie J Lee
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Blood 110:4576-83. 2007
    ..High-resolution DNA matching for HLA-A, -B, -C, and -DRB1 alleles is associated with higher rates of survival...
  4. pmc High-resolution, high-throughput HLA genotyping by next-generation sequencing
    G Bentley
    Department of Human Genetics, Roche Molecular Systems Inc, Pleasanton, CA 94588, USA
    Tissue Antigens 74:393-403. 2009
    ....
  5. ncbi Next-generation sequencing: the solution for high-resolution, unambiguous human leukocyte antigen typing
    C Lind
    Department of Pathology and Laboratory Medicine, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Hum Immunol 71:1033-42. 2010
    ..NGS can provide complete, unambiguous, high-resolution HLA typing; however, further evaluation is needed to explore the feasibility of its routine use...
  6. ncbi Rapid high-throughput human leukocyte antigen typing by massively parallel pyrosequencing for high-resolution allele identification
    Christian Gabriel
    Red Cross Transfusion Service of Upper Austria, Krankenhausstrasse 7, 4017 Linz, Austria
    Hum Immunol 70:960-4. 2009
    ..Furthermore, current investments for increased read lengths and fully automated molecular diagnostic software tools, using original GS-FLX data file formats, will enhance this novel HLA typing strategy in the near future...
  7. ncbi Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome
    Neal Flomenberg
    Department of Medicine and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Blood 104:1923-30. 2004
    ..When clinical circumstances allow, high-resolution class I typing may help optimize donor selection and improve outcome...
  8. ncbi Common and well-documented HLA alleles: report of the Ad-Hoc committee of the american society for histocompatiblity and immunogenetics
    Pedro Cano
    University of Texas M D Anderson Cancer Center, HLA Typing Laboratory, Houston, Texas 77054, USA
    Hum Immunol 68:392-417. 2007
    In histocompatibility testing some genotype ambiguities are almost always resolved into the genotype with the most common alleles. To achieve unambiguous assignments additional unwieldy tests are performed...
  9. ncbi Clinical relevance of pretransplant donor-specific HLA antibodies detected by single-antigen flow-beads
    Patrizia Amico
    Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland
    Transplantation 87:1681-8. 2009
    ..The aims of this study were to investigate to which extent HLA-DSA detected by SAFB represent a risk for antibody-mediated rejection (AMR) and diminished allograft survival, and to define HLA-DSA characteristics predictive for AMR...
  10. pmc Sequence capture and next generation resequencing of the MHC region highlights potential transplantation determinants in HLA identical haematopoietic stem cell transplantation
    Johannes Pröll
    Red Cross Transfusion Service for Upper Austria, Linz
    DNA Res 18:201-10. 2011
    ..Taken together, the presented data show that sequence capture and massively parallel pyrosequencing can be used as a new tool for risk assessment in the setting of allogeneic stem cell transplantation...
  11. pmc Double unrelated reduced-intensity umbilical cord blood transplantation in adults
    Karen K Ballen
    Division of Hematology Oncology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Biol Blood Marrow Transplant 13:82-9. 2007
    ..Our findings indicate that adult patients can tolerate double UBC transplantation well and achieve sustained antitumor responses using this reduced-intensity conditioning regimen...
  12. pmc A novel single cDNA amplicon pyrosequencing method for high-throughput, cost-effective sequence-based HLA class I genotyping
    Simon M Lank
    Wisconsin National Primate Research Center, University of Wisconsin Madison, Madison, Wisconsin, USA
    Hum Immunol 71:1011-7. 2010
    ..Unprecedented typing throughput results from a novel single cDNA-PCR amplicon strategy requiring only 1 PCR amplification per sample. This method dramatically reduces cost for genotyping of large cohorts...
  13. ncbi Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy
    Juliet N Barker
    Blood and Marrow Transplant Program, Division of Medical and Pediatric Oncology, University of Minnesota, Box 480, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Blood 105:1343-7. 2005
    ..Therefore, transplantation of 2 partially HLA-matched UCB units is safe, and may overcome the cell-dose barrier that limits the use of UCB in many adults and adolescents...
  14. ncbi HLA-DQB1 and -DQA1 typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours
    O Olerup
    Center for Biotechnology, Karolinska Institute, Novum, Huddinge, Sweden
    Tissue Antigens 41:119-34. 1993
    ..The cost for typing one individual is low and is independent of the number of samples analyzed simultaneously, i.e. the technique is well-suited for routine clinical use...
  15. ncbi The impact of HLA genotyping on survival following unrelated donor haematopoietic stem cell transplantation
    Bronwen E Shaw
    Research Department, Anthony Nolan Research Institute, London, UK
    Br J Haematol 150:251-8. 2010
    ..e. matched for HLA-A, -B, -C, -DRB1, however, in certain circumstances, mismatches may be tolerated and/or permissive...
  16. ncbi Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia
    Mary J Laughlin
    Case Comprehensive Cancer Center and University Hospitals of Cleveland Ireland Cancer Center, Cleveland, USA
    N Engl J Med 351:2265-75. 2004
    ..Data regarding the outcome of cord-blood transplantation in adults are scant, despite the fact that these grafts are increasingly used in adults...
  17. pmc Common and well-documented HLA alleles: 2012 update to the CWD catalogue
    S J Mack
    Center for Genetics, Children s Hospital Oakland Research Institute, Oakland, CA, USA
    Tissue Antigens 81:194-203. 2013
    ..This version 2.0.0 of the CWD catalogue is available online at cwd.immunogenomics.org, and will be integrated into the Allele Frequencies Net Database, the IMGT/HLA Database and National Marrow Donor Program's bioinformatics web pages...
  18. ncbi Impact of donor-specific antibodies on chronic rejection occurrence and graft loss in renal transplantation: posttransplant analysis using flow cytometric techniques
    A Piazza
    Consiglio Nazionale delle Ricerche, Institute of Tissue Typing, Unit of Rome, Italy
    Transplantation 71:1106-12. 2001
    ....
  19. ncbi Clinical relevance of pretransplant donor-directed antibodies detected by single antigen beads in highly sensitized renal transplant patients
    Ella M van den Berg-Loonen
    University Hospital Maastricht, The Netherlands
    Transplantation 85:1086-90. 2008
    ..The standard crossmatch in the AM program is based on complement-dependent cytotoxicity...
  20. ncbi 16(th) IHIW : review of HLA typing by NGS
    D De Santis
    Department of Clinical Immunology, PathWest, Royal Perth Hospital, Perth, WA, Australia
    Int J Immunogenet 40:72-6. 2013
    ..The developments presented at this workshop clearly highlight the potential benefits of NGS in the HLA laboratory...
  21. pmc Surveillance of alloantibodies after transplantation identifies the risk of chronic rejection
    Pamela M Kimball
    Department of Transplant Surgery, Virginia Commonwealth University Health Systems, Richmond, Virginia 23219, USA
    Kidney Int 79:1131-7. 2011
    ..Thus, systematic assessment of longitudinal changes in alloantibody levels, either by FCXM or solid-phase assay, can help identify patients at greater risk of developing CR...
  22. pmc Rapid, scalable and highly automated HLA genotyping using next-generation sequencing: a transition from research to diagnostics
    Martin Danzer
    Department of Immunogenetics, Red Cross Transfusion Service for Upper Austria, Krankenhausstrasse 7, Linz 4017, Austria
    BMC Genomics 14:221. 2013
    ..Therefore, we have developed and validated a scalable automated HLA class I and class II typing approach suitable for diagnostic use...
  23. pmc Graft-versus-host disease
    James L M Ferrara
    University of Michigan, Pediatrics and Internal Medicine, Blood and Marrow Transplantation Program, Ann Arbor, MI 48109 5942, USA
    Lancet 373:1550-61. 2009
    ..We also summarise supportive-care measures that are essential for management of this medically fragile population...
  24. ncbi Bone marrow transplantation from unrelated donors: the impact of mismatches with substitutions at position 116 of the human leukocyte antigen class I heavy chain
    G B Ferrara
    Laboratorio di Immunogenetica, Servizio di Epidemiologia Clinica, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    Blood 98:3150-5. 2001
    ..001), and 25% versus 31% (P =.4). In conclusion these data suggest that substitutions at position 116 of class I heavy chain increase the risk for acute GVHD and TRM in patients who receive transplanted bone marrow from unrelated donors...
  25. ncbi Does a positive lymphocyte cross-match contraindicate living-donor liver transplantation?
    Tomohide Hori
    Department of Transplant Surgery, Kyoto University Hospital, Kyoto, Japan
    Surgery 147:840-4. 2010
    ..There is still no consensus on the importance of lymphocyte cross-matching (LCM) in the field of living-donor liver transplantation (LDLT)...
  26. ncbi HIV-1-specific cytotoxic T lymphocyte (CTL) responses against immunodominant optimal epitopes slow the progression of AIDS in China
    Song Zhai
    Department of Infectious Diseases, Tangdu Hospital Affiliated to the Fourth Military Medical University, Xi an, P R China
    Curr HIV Res 6:335-50. 2008
    ....
  27. ncbi Hematopoietic stem cell donor registry strategies for assigning search determinants and matching relationships
    C K Hurley
    Department of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA
    Bone Marrow Transplant 33:443-50. 2004
    ....
  28. ncbi Positive lymphocytotoxic crossmatch does not adversely affect survival in living donor liver transplantation
    Yasuhiko Sugawara
    Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Dig Surg 26:482-6. 2009
    ..The influence of lymphocytotoxic crossmatch on survival or acute rejection in liver transplantation remains controversial. Data regarding graft survival and acute rejection of living donor liver transplantation (LDLT) are limited...
  29. doi National marrow donor program HLA matching guidelines for unrelated adult donor hematopoietic cell transplants
    Robert A Bray
    Department of Pathology, Emory University, Atlanta, Georgia, USA
    Biol Blood Marrow Transplant 14:45-53. 2008
  30. ncbi Killer Ig-like receptor haplotype analysis by gene content: evidence for genomic diversity with a minimum of six basic framework haplotypes, each with multiple subsets
    Katharine C Hsu
    Immunology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 169:5118-29. 2002
    ..Additional rare haplotypes can be identified, and may have arisen by gene duplication, intergenic recombination, or deletions...
  31. pmc Effect of T-cell-epitope matching at HLA-DPB1 in recipients of unrelated-donor haemopoietic-cell transplantation: a retrospective study
    Katharina Fleischhauer
    Unit of Molecular and Functional Immunogenetics, Division of Regenerative Medicine, Stem Cells and Gene Therapy, Istituto di Ricovero e Cura a Carattere Scientifico H San Raffaele, Milan, Italy
    Lancet Oncol 13:366-74. 2012
    ..We did a retrospective study to compare outcomes between permissive and non-permissive HLA-DPB1 mismatches in unrelated-donor haemopoietic-cell transplantation...
  32. ncbi Limits of HLA mismatching in unrelated hematopoietic cell transplantation
    Effie W Petersdorf
    Division of Clinical Research, D4 100 Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Blood 104:2976-80. 2004
    ..Whenever possible, HLA-C mismatches should be avoided for patients with early stage CML, and HLA-DQB1 mismatches should be avoided for patients with multiple mismatches...
  33. ncbi Phototyping: comprehensive DNA typing for HLA-A, B, C, DRB1, DRB3, DRB4, DRB5 & DQB1 by PCR with 144 primer mixes utilizing sequence-specific primers (PCR-SSP)
    M Bunce
    Nuffield Department of Surgery, Churchill Hospital, Oxford, UK
    Tissue Antigens 46:355-67. 1995
    ..Approximately 5% of genotypes were repeated (either partially or fully) because of incomplete or equivocal results...
  34. ncbi Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study
    Mary Eapen
    Statistical Center, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI, USA
    Lancet 369:1947-54. 2007
    ....
  35. pmc Evidence for the presentation of major histocompatibility complex class I-restricted Epstein-Barr virus nuclear antigen 1 peptides to CD8+ T lymphocytes
    Kui Shin Voo
    Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA
    J Exp Med 199:459-70. 2004
    ....
  36. pmc A statistical method for predicting classical HLA alleles from SNP data
    Stephen Leslie
    Department of Statistics, University of Oxford, Oxford OX1 3TG, UK
    Am J Hum Genet 82:48-56. 2008
    ....
  37. ncbi High-resolution human leukocyte antigen allele and haplotype frequencies of the Polish population based on 20,653 stem cell donors
    Alexander H Schmidt
    DKMS German Bone Marrow Donor Center, Tubingen, Germany
    Hum Immunol 72:558-65. 2011
    ..3 million additional German donors...
  38. ncbi Immunogenetics of HLA null alleles: implications for blood stem cell transplantation
    H A Elsner
    MMD Medical Molecular Diagnostics GmbH, Fiedlerstr 34, Dresden, Germany
    Tissue Antigens 64:687-95. 2004
    ..This approach will detect 36/40 so far known non-expressed variants and has the potential to easily uncover novel variants, thus essentially minimizing the risk of overlooking these challenging variants...
  39. ncbi Histocompatibility testing of cultivated human bone marrow stromal cells - a promising step towards pre-clinical screening for allogeneic stem cell therapy
    Purushotham Reddy Koppula
    C TRACER, Hyderabad Eye Research Foundation, L V Prasad Eye Institute, Hyderabad, India
    Cell Immunol 259:61-5. 2009
    ..Although, the results are encouraging for potential clinical application of MSC transplantation, autologous is always preferable to allogeneic, at least until the long-term safety of these cells is established in clinical trials...
  40. ncbi HLA class I polymorphism, as characterised by PCR-SSOP, in a Brazilian exogamic population
    K Braun-Prado
    Laboratory of Human Molecular Genetics, Federal University of Parana, Curitiba, Brazil
    Tissue Antigens 56:417-27. 2000
    ....
  41. pmc Optimal HLA matching in hematopoietic cell transplantation
    Effie W Petersdorf
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D4 100, Seattle, WA 98109 1024, United States
    Curr Opin Immunol 20:588-93. 2008
    ..Optimizing the overall outcome of hematopoietic cell transplantation requires an appreciation for the relative importance of HLA factors with respect to other non-genetic factors that also influence transplant outcome...
  42. ncbi Preimplantation genetic diagnosis for haematologic conditions
    Tarek El-Toukhy
    Centre for Preimplantation Genetic Diagnosis, Guy s and St Thomas Hospital NHS Foundation Trust, London, UK
    Curr Opin Pediatr 22:28-34. 2010
    ..The history and ethics involved in performing PGD together with human leukocyte antigen (HLA) testing (PGD-H) to create matched siblings suitable for haematopoietic stem cell transplant (HSCT) are discussed...
  43. pmc A perspective on the selection of unrelated donors and cord blood units for transplantation
    Stephen R Spellman
    Center for International Blood and Marrow Transplant Research, Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, 9200 West Wisconsin Ave, Milwaukee, WI 53226, USA
    Blood 120:259-65. 2012
    ....
  44. ncbi A community standard XML message format for sequencing-based typing data
    M Maiers
    National Marrow Donor Program, Minneapolis, MN, USA
    Tissue Antigens 69:69-71. 2007
    ....
  45. ncbi Estimation of HLA-A, -B, -DRB1 haplotype frequencies using mixed resolution data from a National Registry with selective retyping of volunteers
    Craig Kollman
    Jaeb Center for Health Research, Tampa, Florida, USA
    Hum Immunol 68:950-8. 2007
    ..We demonstrate the feasibility of using this computationally demanding algorithm on large datasets by applying it to more than 3 million volunteers listed in the National Marrow Donor Program Registry...
  46. ncbi Development of a DNA vaccine designed to induce cytotoxic T lymphocyte responses to multiple conserved epitopes in HIV-1
    Cara C Wilson
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 171:5611-23. 2003
    ..These data indicate that the EP HIV-1090 DNA vaccine may be suitable for inducing relevant HIV-1-specific CTL responses in humans...
  47. ncbi Preimplantation diagnosis for Fanconi anemia combined with HLA matching
    Y Verlinsky
    Reproductive Genetics Institute, Chicago, IL, USA
    JAMA 285:3130-3. 2001
    ..This is a novel and useful way to preselect a potential donor for an affected sibling requiring stem cell transplantation...
  48. ncbi First successful bone marrow transplantation for X-linked chronic granulomatous disease by using preimplantation female gender typing and HLA matching
    Janine Reichenbach
    University Children s Hospital Zurich, Division of Immunology Hematology BMT, Steinwiesstrasse 75, CH 8032 Zurich, Switzerland
    Pediatrics 122:e778-82. 2008
    ....
  49. ncbi HLA typing by SSO and SSP methods
    Heather Dunckley
    Australian Red Cross Blood Service, Sydney, NSW, Australia
    Methods Mol Biol 882:9-25. 2012
    ..Both methods are very useful for clinical and research purposes and can provide generic (low resolution) to allelic (high resolution) typing results. This chapter provides an overview of the SSO and SSP methods in relation to HLA typing...
  50. pmc Support of unrelated stem cell donor searches by donor center-initiated HLA typing of potentially matching donors
    Alexander H Schmidt
    DKMS German Bone Marrow Donor Center, Tubingen, Germany
    PLoS ONE 6:e20268. 2011
    ..Our results also raise questions regarding the appropriate use of incompletely typed donors within unrelated donor searches...
  51. ncbi Histocompatibility testing after fifty years of transplantation
    Hooi Sian Eng
    Department of Medicine, The Johns Hopkins University School of Medicine, USA
    J Immunol Methods 369:1-21. 2011
    b>Histocompatibility testing has been used in support of solid organ and hematopoietic stem cell transplantation for over fifty years and transplantation has clearly served as a major stimulus for interest in the human major ..
  52. ncbi Significance of positive cytotoxic cross-match in adult-to-adult living donor liver transplantation using small graft volume
    Kyung Suk Suh
    Department of Surgery, Seoul National University College of Medicine, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea
    Liver Transpl 8:1109-13. 2002
    ..035). In conclusion, when lymphocytotoxic cross-match and flow cytometry are significantly positive, adult-to-adult LDLT using small-for-size grafts should not be performed...
  53. ncbi Preformed antibodies detected by cytotoxic assay or multibead array decrease liver allograft survival: role of human leukocyte antigen compatibility
    Marcela Castillo-Rama
    Department of Immunology, Hospital Doce de Octubre, Madrid, Spain
    Liver Transpl 14:554-62. 2008
    ....
  54. ncbi The probability of identifying a 10/10 HLA allele-matched unrelated donor is highly predictable
    J M Tiercy
    Department of Internal Medicine, National Reference Laboratory for Histocompatibility, University Hospital, Geneva, Switzerland
    Bone Marrow Transplant 40:515-22. 2007
    ..Probability prediction is therefore feasible in the search process for unrelated donors and can guide the therapeutic strategy...
  55. ncbi Definitions of histocompatibility typing terms: Harmonization of Histocompatibility Typing Terms Working Group
    Eduardo Nunes
    AABB, Bethesda, Maryland, USA
    Hum Immunol 72:1214-6. 2011
    b>Histocompatibility testing for stem cell and solid organ transplantation has become increasingly complex as newly discovered human leukocyte antigen (HLA) alleles are described...
  56. ncbi Resolution of HLA class I sequence-based typing ambiguities by group-specific sequencing primers
    T V Lebedeva
    HLA Laboratory, American Red Cross Blood Services, New England Region, Dedham, MA 02026, USA
    Tissue Antigens 77:247-50. 2011
    ..The panel of GSSPs used in our laboratory includes 14 primers for HLA-A, 18 for HLA-B, and 13 primers for HLA-C. The panel resolves 99.9% of all ambiguities...
  57. ncbi CD3+/CD19+-depleted grafts in HLA-matched allogeneic peripheral blood stem cell transplantation lead to early NK cell cytolytic responses and reduced inhibitory activity of NKG2A
    D N Eissens
    Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Leukemia 24:583-91. 2010
    ..These results show that the use of CD3(+)/CD19(+)-depleted grafts facilitates strong NK cell cytolytic responses directly after SCT, and the rapid emergence of an NK cell receptor phenotype that is more prone to activation...
  58. pmc T cell-depleted partial matched unrelated donor transplant for advanced myeloid malignancy: KIR ligand mismatch and outcome
    Daniel Weisdorf
    University of Minnesota, Minneapolis, Minneapolis, MN 55455, USA
    Biol Blood Marrow Transplant 18:937-43. 2012
    ..Improvements in peritransplantation disease control and additional measures to augment the allogeneic graft-versus-leukemia effect are still required...
  59. ncbi Human leucocyte antigen typing: techniques and technology, a critical appraisal
    P P J Dunn
    Tissue Typing Laboratory, New Zealand Blood Service, Auckland, New Zealand
    Int J Immunogenet 38:463-73. 2011
    ..This review describes the merits and disadvantages of current technologies available to HLA Typing laboratories, future trends and the problems posed by new alleles...
  60. pmc High-resolution HLA matching in double-umbilical-cord-blood reduced-intensity transplantation in adults
    Meghan Delaney
    Puget Sound Blood Center, Seattle, Washington 98104, USA
    Transfusion 49:995-1002. 2009
    ..Double-cord-blood transplantation (DCBT) offers an option for patients receiving reduced-intensity transplants. These unique transplants have two donors, both of whom are usually HLA mismatched at one to two loci...
  61. ncbi Sensitivity, specificity and clinical relevance of different cross-matching assays in deceased-donor renal transplantation
    E K Ho
    Department of Pathology, Columbia University, New York, NY 10032, USA
    Transpl Immunol 20:61-7. 2008
    ..SPA and FC, however, are of great importance for identifying patients which require close monitoring by biopsy and serology for early diagnosis and treatment of acute antibody mediated rejection (AAMR)...
  62. ncbi HLA-B Bw4 alleles and HIV-1 transmission in heterosexual couples
    Tania M Welzel
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA
    AIDS 21:225-9. 2007
    ..Genetic factors may play a role in the transmission of HIV-1. Because HLA-B alleles influence HIV-1 disease progression and viral levels, they might also influence HIV-1 transmission...
  63. ncbi Serial ten-year follow-up of HLA and MICA antibody production prior to kidney graft failure
    Kazuo Mizutani
    Terasaki Foundation Laboratory, Los Angeles, California, USA
    Am J Transplant 5:2265-72. 2005
    ..These antibodies found in the peripheral circulation, were not necessarily donor-specific, but their association with failure is consistent with a causality hypothesis...
  64. pmc Influence of infused cell dose and HLA match on engraftment after double-unit cord blood allografts
    Sharon Avery
    Department of Medicine, Adult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Blood 117:3277-85; quiz 3478. 2011
    ..0001). Our findings have important implications for unit selection and provide further insight into double-unit biology...
  65. ncbi The clinical significance of human leukocyte antigen (HLA) allele compatibility in patients receiving a marrow transplant from serologically HLA-A, HLA-B, and HLA-DR matched unrelated donors
    Yasuo Morishima
    Department of Hematology and Chemotherapy, the Division of Epidemiology and Prevention, Aichi Cancer Center, Japan
    Blood 99:4200-6. 2002
    ..Thus, the role of the HLA class I allele in unrelated bone marrow transplantation was elucidated. Notably, HLA-C alleles had a different mode from HLA-A or -B alleles for acute GVHD and survival...
  66. ncbi Strategies for human leukocyte antigen antibody detection
    Robert A Bray
    Department of Pathology, Emory University Hospital, Atlanta, GA 30322, USA E mail
    Curr Opin Organ Transplant 14:392-7. 2009
    ..Not surprisingly, improved antibody detection has brought new challenges to the HLA community. The challenge is how best to utilize this new information in a way that facilitates, not hinders, appropriate transplantation...
  67. doi Advances in the selection of HLA-compatible donors: refinements in HLA typing and matching over the first 20 years of the National Marrow Donor Program Registry
    Stephen Spellman
    National Marrow Donor Program, Minneapolis, Minnesota 55413, USA
    Biol Blood Marrow Transplant 14:37-44. 2008
  68. ncbi An update on the management of severe idiopathic aplastic anaemia in children
    Jeffrey K Davies
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Br J Haematol 136:549-64. 2007
    ..Emerging therapies that capitalise on recent advances in our understanding of the pathophysiology of idiopathic AA and the immunobiology of AHSCT and IST may further improve the long-term outcome of this disease...
  69. pmc High donor FOXP3-positive regulatory T-cell (Treg) content is associated with a low risk of GVHD following HLA-matched allogeneic SCT
    Katayoun Rezvani
    Stem Cell Allogeneic Transplant Section, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1202, USA
    Blood 108:1291-7. 2006
    ..Our findings suggest that graft T(reg) content may predict for risk of GVHD after SCT. Determining the T(reg) levels in the donor and manipulating T(reg)s early after transplantation may provide a new approach to controlling GVHD...
  70. ncbi Unrelated donor hematopoietic cell transplantation: marrow or umbilical cord blood?
    Satkiran S Grewal
    University of Minnesota, 420 Delaware St SE, MMC 477, Minneapolis, MN 55455, USA
    Blood 101:4233-44. 2003
  71. ncbi Determinants of antileukemia effects of allogeneic NK cells
    Wing Leung
    Department of Hematology Oncology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    J Immunol 172:644-50. 2004
    ..These findings provide new insights into the determinants of antileukemia effects of allogeneic NK cells and therapeutic strategies...
  72. ncbi Alloantibody levels and acute humoral rejection early after positive crossmatch kidney transplantation
    J M Burns
    Division of Transplant Surgery, Department of Surgery, Mayo Clinic, Rochester, MN, USA
    Am J Transplant 8:2684-94. 2008
    ..We conclude that AHR is associated with the development of High DSA levels posttransplant and protocols aimed at maintaining DSA at lower levels may decrease the incidence of AHR...
  73. ncbi Criteria for initiation and evaluation of minority donor programs and application to the example of donors of Turkish descent in Germany
    A H Schmidt
    DKMS German Bone Marrow Donor Center, Kressbach 1, 72072 Tubingen, Germany
    Bone Marrow Transplant 44:405-12. 2009
    ..The analysis of donations from minority donors, however, shows specific benefits for patients with rare HLA phenotypes...
  74. ncbi Transfusion-related acute lung injury surveillance (2003-2005) and the potential impact of the selective use of plasma from male donors in the American Red Cross
    Anne F Eder
    Biomedical Services, National Headquarters, American Red Cross, Washington, DC 20006, USA
    Transfusion 47:599-607. 2007
    ....
  75. ncbi Results of a HOVON/SAKK donor versus no-donor analysis of myeloablative HLA-identical sibling stem cell transplantation in first remission acute myeloid leukemia in young and middle-aged adults: benefits for whom?
    Jan J Cornelissen
    Department of Hematology, Erasmus University Medical Center, Groene Hilledijk 301, 3075 EA Rotterdam, The Netherlands
    Blood 109:3658-66. 2007
    ....
  76. ncbi New HLA haplotype frequency reference standards: high-resolution and large sample typing of HLA DR-DQ haplotypes in a sample of European Americans
    W Klitz
    Children s Hospital Oakland Research Institute, Oakland, CA, USA
    Tissue Antigens 62:296-307. 2003
    ..Four DQA1-DQB1 haplotypes, all rare, are reported here for the first time. The haplotype frequency tables are suitable as a reference standard for HLA typing of the DR and DQ loci in European Americans...
  77. ncbi Toward an understanding of transfusion-related acute lung injury: statement of a consensus panel
    Steven Kleinman
    Kleinman Biomedical Research, Victoria, British Columbia, Canada
    Transfusion 44:1774-89. 2004
  78. ncbi The minor histocompatibility antigen HA-1: a diallelic gene with a single amino acid polymorphism
    J M den Haan
    Department of Immunohematology and Bloodbank, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Science 279:1054-7. 1998
    ..HA-1 allele typing of donor and recipient should improve donor selection and allow the determination of bone marrow transplantation recipients with high risk for HA-1-induced GvHD development...
  79. ncbi Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia
    Vanderson Rocha
    Hopital Saint Louis, Assistance Publique des Hôpitaux de Paris and Paris University, Paris, France
    N Engl J Med 351:2276-85. 2004
    ..Promising results of cord-blood transplants from unrelated donors have been reported in adults...
  80. ncbi A framework to sub-type HLA supertypes
    Pandjassarame Kangueane
    School of Mechanical and Production Engineering, Nanyang Technological University, Nanyang Centre for Supercomputing and Visualization, Singapore 639798
    Front Biosci 10:879-86. 2005
    ..A complete knowledge of this phenomenon finds utility in epitope design for the development of HLA based vaccines and immuno-therapeutics...
  81. ncbi Human leukocyte antigen matching estimations in a hypothetical bank of human embryonic stem cell lines in the Japanese population for use in cell transplantation therapy
    Fumiaki Nakajima
    Research and Development Department, Central Blood Institute, Japanese Red Cross Society, Tokyo, Japan
    Stem Cells 25:983-5. 2007
    ..Moreover, parthenogenetic hES cell lines can greatly reduce the number required for a higher degree of HLA matching...
  82. ncbi Evaluation of 28 human embryonic stem cell lines for use as unrelated donors in stem cell therapy: implications of HLA and ABO genotypes
    Jeoung Eun Lee
    CHA Stem Cell Institute, CHA University, Seoul, Korea
    Cell Transplant 19:1383-95. 2010
    ..We provided the first report on the HLA and ABO genotypes of hESC lines, and estimated the degree of HLA and ABO matching in organ transplantation for the Korean population...
  83. ncbi Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival
    John E Wagner
    Blood and Marrow Transplant Program of the Department of Pediatrics, University of Minnesota Cancer Center and School of Medicine, Minneapolis 55455, USA
    Blood 100:1611-8. 2002
    ..7 x 10(5) CD34(+) cells per kilogram of recipient's body weight. Therefore, graft selection should be based principally on CD34 cell dose when multiple UCB units exist with an HLA disparity of 2 or less...
  84. ncbi Identification of the antibodies involved in B-cell crossmatch positivity in renal transplantation
    Stéphanie Le Bas-Bernardet
    Laboratoire d Histocompatibilite, Etablissement de Transfusion Sanguine, Nantes, France
    Transplantation 75:477-82. 2003
    ..The significance of a positive B-cell crossmatch (BCM) in kidney transplantation has always been controversial in the evaluation of its implications on graft survival and specificity of the antibodies involved...
  85. ncbi Clinical relevance of preformed HLA donor-specific antibodies in kidney transplantation
    C Lefaucheur
    Department of Nephrology, Saint Louis Hospital, Paris, France
    Am J Transplant 8:324-31. 2008
    ..Our findings demonstrate the importance of detection and characterization of DSA before transplantation. Stratification of this risk could be used to determine kidney allocation and to devise specific strategies for these patients...
  86. ncbi Improving outcomes of cord blood transplantation: HLA matching, cell dose and other graft- and transplantation-related factors
    Vanderson Rocha
    Department of Haematology, Eurocord Netcord EBMT office, Institut universitaire, Hopital Saint Louis, Universite de Paris 7, 1 av Claude Vellefaux, 75010 Paris, France
    Br J Haematol 147:262-74. 2009
    ..This review will focus on the interactions between HLA, cell dose and other modifiable factors related to the UCB unit selection and transplantation that may improve outcomes after UCB transplantation...
  87. ncbi Long-term results of allogeneic penetrating limbo-keratoplasty in total limbal stem cell deficiency
    Thomas Reinhard
    Eye Hospital, Albert Ludwigs University, Killianstrasse 5, 79106 Freiburg, Germany
    Ophthalmology 111:775-82. 2004
    ..To determine the prognosis of allogeneic penetrating limbo-keratoplasty in patients with total limbal stem cell deficiency and to find out if donor limbal stem cells survive in the long run...
  88. ncbi Baseline donor-specific antibody levels and outcomes in positive crossmatch kidney transplantation
    J M Gloor
    Division of Nephrology and Hypertension and Transplant Center, Department of Internal Medicine, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Am J Transplant 10:582-9. 2010
    ..With current protocols, very high baseline DSA patients have high rates of AMR and poor long-term allograft survival highlighting the need for improved therapy for these candidates...
  89. ncbi World Marrow Donor Association guidelines for use of HLA nomenclature and its validation in the data exchange among hematopoietic stem cell donor registries and cord blood banks
    W Bochtler
    Information Technology and Quality Assurance Working Groups of the World Marrow Donor Association, Leiden, The Netherlands
    Bone Marrow Transplant 39:737-41. 2007
    ..Two reference web sites have been designated to maintain and update the approved HLA nomenclature and all the ancillary information needed by the conventions described here...
  90. ncbi Prediction of crossmatch outcome of highly sensitized patients by single and/or multiple antigen bead luminex assay
    Smita Vaidya
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Transplantation 82:1524-8. 2006
    ..We used a solid-phase assay to identify human leukocyte antigen (HLA) Class I and II specificities in highly reactive sera, and applied this information to predict crossmatch outcome with greater than 90% accuracy...
  91. ncbi Reanalysis of sequence-based HLA-A, -B and -Cw typings: how ambiguous is today's SBT typing tomorrow
    C E M Voorter
    Tissue Typing Laboratory, University Hospital Maastricht, Maastricht, The Netherlands
    Tissue Antigens 70:383-9. 2007
    ..These results indicate that within 5 years, approximately half of the HLA SBT typings become ambiguous...
  92. ncbi HLA-DRB1*0102 is associated with TINU syndrome and bilateral, sudden-onset anterior uveitis but not with interstitial nephritis alone
    F Mackensen
    Interdisciplinary Uveitis Center, University Eye Hospital, INF 400, 69120 Heidelberg, Germany
    Br J Ophthalmol 95:971-5. 2011
    ..Here, the authors performed HLA analysis on subjects with isolated bilateral sudden-onset uveitis (as in the TINU subtype) or with isolated tubulointerstitial nephritis (TIN)...
  93. ncbi Efforts of the United States' National Marrow Donor Program and Registry to improve utilization and representation of minority donors
    K A Johansen
    Division of Science, Medicine, and Public Health, American Medical Association, Chicago, IL 60610, USA
    Transfus Med 18:250-9. 2008
    ..The procedures and experience of the NMDP and its Registry may have implications for registries elsewhere in the world as they confront similar issues of number and diversity...
  94. ncbi Molecular typing of HLA genes using whole genome amplified DNA
    Lisa E Creary
    Histocompatibility and Immunogenetics Research Group, Department of Histocompatibility and Immunogenetics, Colindale Centre, NHSBT, NHSBT, London, UK
    Transfusion 49:57-63. 2009
    ....
  95. ncbi No association of kidney graft loss with human leukocyte antigen antibodies detected exclusively by sensitive Luminex single-antigen testing: a Collaborative Transplant Study report
    Caner Süsal
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
    Transplantation 91:883-7. 2011
    ....
  96. ncbi Acceptable donor-specific antibody levels allowing for successful deceased and living donor kidney transplantation after desensitization therapy
    Nancy L Reinsmoen
    HLA Laboratory, Cedars Sinai Medical Center, 8723 Alden Drive, SSB 197, Los Angeles, CA 90048, USA
    Transplantation 86:820-5. 2008
    ....
  97. ncbi Calculated PRA: initial results show benefits for sensitized patients and a reduction in positive crossmatches
    J M Cecka
    UCLA Immunogenetics Center, Department of Pathology, University of California Los Angeles, Los Angeles, CA, USA
    Am J Transplant 11:719-24. 2011
    ....
  98. ncbi Preimplantation diagnosis and HLA typing for haemoglobin disorders
    A Kuliev
    Reproductive Genetics Institute, Chicago IL, 60657, USA
    Reprod Biomed Online 11:362-70. 2005
    ..The results show that PGD has now become a practical approach for prevention of haemoglobin disorders, and is gradually being used also for improving access to HLA compatible stem cell transplantation for this group of diseases...
  99. ncbi Maximizing optimal hematopoietic stem cell donor selection from registries of unrelated adult volunteers
    C K Hurley
    Department of Oncology, CW Bill Young Marrow Donor Recruitment and Research Program, Georgetown University Medical Center, 3970 Reservoir Road NW, Washington, DC 20057, USA
    Tissue Antigens 61:415-24. 2003
    ..Within registries, HLA frequency data have been used to evaluate optimal registry size and composition...
  100. ncbi Kidney transplantation in patients with antibodies against donor HLA class II
    H S Pollinger
    Division of Transplantation Surgery, Mayo Clinic College of Medicine, Rochester, MN, USA
    Am J Transplant 7:857-63. 2007
    ..We conclude that KTx recipients with clearly defined anti-Class II DSA are at risk for humoral rejection suggesting that desensitization and/or close posttransplant monitoring may be needed to prevent AMR...
  101. ncbi Human leucocyte antigen risk alleles for psoriatic arthritis among patients with psoriasis
    Lihi Eder
    Centre for Prognosis Studies in Rheumatic Diseases, Toronto Western Hospital, Toronto, Canada
    Ann Rheum Dis 71:50-5. 2012
    ..The authors aimed to identify human leucocyte antigen (HLA) alleles that are associated with the development of PsA in patients with psoriasis...

Research Grants71

  1. COLLABORATIVE CORNEAL TRANSPLANTATION STUDIES
    Gary Foulks; Fiscal Year: 1991
    ..Corneal Transplantation Studies (CCTS) consist of two multicenter studeis of the effectiveness of histocompatibility testing in preventing corneal allograft rejection in high risk patients...
  2. COORDINATING LABORATORY CORNEAL TRANSPLANTATION STUDIES
    WILMA BIAS; Fiscal Year: 1991
    ..or HLA-matched donor corneas to patients with high risk of rejection will require the services of a histocompatibility testing laboratory at each transplanting center...
  3. MECHANISMS IN HUMAN CANCER IMMUNOLOGY SYMPOSIUM
    J Saunders; Fiscal Year: 1980
    ..Similar symposia on histocompatibility testing, antibody formation and mediators of cellular immunity have in the past successfully met their goals of ..
  4. SNPs in Lung Cancer Risk and Therapeutic Response
    Effie Petersdorf; Fiscal Year: 2004
    ..abstract_text> ..
  5. OPTIMIZING BMT FOR CANCER BY GENETIC MATCHING OF DONORS
    Effie Petersdorf; Fiscal Year: 2003
    ....
  6. 14th International HLA & Immunogenetics Workship (HIWS)
    John Hansen; Fiscal Year: 2005
    ..The scientific exchange that will take place at the meeting will drive research and maintain international collaboration in immunogenetics for the next 5 years. ..
  7. Whole Genome Association Analysis of Hematopoietic Cell Transplant Outcome
    John Hansen; Fiscal Year: 2008
    ..The third stage will explore genome-genome interactions between recipient and donor. [unreadable] [unreadable] [unreadable]..
  8. Nonmyeloablative Allografting for Hematologic Neoplasia
    Michael Maris; Fiscal Year: 2005
    ....
  9. ICAM1 gene inactivation protects against ischemic injury
    Robert Montgomery; Fiscal Year: 2006
    ..This work has important implications for the selective inactivation of gene function in allografts through ex vivo gene transfer. ..
  10. Function & Fate of Alloantigen-specific CD8 Cell in GVHD
    Paul Martin; Fiscal Year: 2005
    ..The studies proposed in this application will help clarify the critical functions and fate of specific donor CD8 cell population that cause GVHD. ..
  11. Genetic/Immunological Basis of Tuberculosis and Anergy
    Julio Delgado; Fiscal Year: 2005
    ..It is anticipated that these results will be useful in the development of genetic and immune therapeutic strategies to combat tuberculosis. ..
  12. MENTORED STUDY OF RENAL TRANSPLANT ALLOCATION EFFICIENCY
    Mark Schnitzler; Fiscal Year: 2005
    ....
  13. VLA4 IN CTL MEDIATED ISLET ALLOGRAFT REJECTION
    Mark Stegall; Fiscal Year: 2001
    ..The approach may lead to novel forms of immune suppression that may benefit not only islet transplantation, but also other types of organ allografts. ..
  14. TEMPORALLY CONTROLLED DEPLETION OF ALLOREACTIVE T CELLS
    Paul Martin; Fiscal Year: 2002
    ..Results of these preclinical studies will help to assess the potential risks and benefits of using similar approaches to prevent GVHD in human marrow transplantation. ..
  15. Vaccine efficacy post related and unrelated HCT
    Trudy Small; Fiscal Year: 2004
    ..abstract_text> ..
  16. Preimplantation Genetic Diagnosis & Genetic Modification
    John Robertson; Fiscal Year: 2003
    ..It will explore whether prevailing conceptions of procreative and family liberty include the right of prospective parents to alter or modify the genome of offspring for medical or non-medical purposes. ..
  17. CD4 Regulator T Cells Suppress Alloreactivity after BMT
    Bryon Johnson; Fiscal Year: 2005
    ..The information obtained will contribute significantly to our understanding of the role of regulatory T cells in mediating dominant peripheral tolerance after allo-BMT and could lead to translational applications in clinical BMT. ..
  18. Natural IgM antilymphocyte autoantibodies inhibit HIV-1
    PETER LOBO; Fiscal Year: 2003
    ..A successful outcome with the proposed studies could better our understanding on pathogenesis of H1V-1 infection and may provide strategies to prolong the asymptomatic state after HIV-1 infection. ..
  19. Mycophenylate mofetil for treatment of chronic GVHD
    Paul Martin; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  20. Innate Cellular Lectin-Mediated Binding of Xenogeneic Antigens
    Michael Rees; Fiscal Year: 2009
    ..This work will advance our understanding of macrophage recognition of foreign sugars from other species and make ECLP a more useful tool in treating fulminant hepatic failure. ..
  21. CD4(-) and CD8(-) T Cells in Autoimmune & Normal Mice
    Samuel Strober; Fiscal Year: 2006
    ..The latter cells will be transferred to non-transgenic NZB/NZW hosts to determine their contribution to IgG autoantibody secretion. ..
  22. XENOGENEIC BIOARTIFICAL LIVER
    Scott L Nyberg; Fiscal Year: 2010
    ..Demonstration of efficacy in a pre-clinical model of FHF, as proposed in this application, will provide a basis for future clinical trials of the spheroid reservoir BAL. ..
  23. Bone Marrow Angioblasts for Myocardial Vasculogenesis
    Silviu Itescu; Fiscal Year: 2006
    ..abstract_text> ..
  24. PATHOGENESIS OF POST-TRANSPLANT BRONCHIOLITIS OBLITERANS
    Thalachallour Mohanakumar; Fiscal Year: 2008
    ..BOS following clinical lung transplantation. ..
  25. Role of Cytokines and Autoimmunity in Murine BA
    Cara Mack; Fiscal Year: 2005
    ..Defining the immunopathology in biliary atresia will lead to a better understanding of the etiopathogenesis and provide insight into future therapeutic options. ..
  26. Enhancing Doctor-Patient Communication
    Stephanie Lee; Fiscal Year: 2006
    ..The project works towards the overall goal of enhancing communication, improving patient understanding, and facilitating psychosocial adaptation to life-threatening illness. ..
  27. Spondyloarthritis 2006; The Unmet Needs
    John Reveille; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  28. QMS Technology to Deplete T Cell Alloreactivity
    Sherif Farag; Fiscal Year: 2008
    ..abstract_text> ..
  29. Liver Disease and HIV-HBV Coinfection in the HAART era
    Chloe Thio; Fiscal Year: 2008
    ..Given the experience of the investigative team and the well-characterized cohorts involved, the results from this proposal will yield insights into the management of HIV-HBV co-infected patients. ..
  30. NATIONAL GENE VECTOR LABORATORY AT INDIANA UNIVERSITY
    Kenneth Cornetta; Fiscal Year: 2007
    ..abstract_text> ..
  31. Phase II Trial of HOKT3gamma 1 (ALA-ALA) in Type 1 Diabetes
    Kevan C Herold; Fiscal Year: 2010
    ..Thus, this proposal will bridge both mechanistic studies and a clinical trial to develop a new treatment paradigm that may be beneficial to a large number of patients with T1DM. ..
  32. Cell Death and Clonal Survival in Myelodysplastic Syndr*
    H Deeg; Fiscal Year: 2008
    ..To achieve these objectives, we must better understand the underlying mechanisms of MDS and thereby identify ways by which the disease process can be arrested, progression prevented, and the disease hopefully be cured. ..
  33. HOX GENE EXPRESSION IN HUMAN ENDOMETRIUM
    Hugh Taylor; Fiscal Year: 2007
    ..These studies will further characterize the molecular mechanisms by which HOX expression is related to normal and pathologic endometrial development. ..
  34. Physician Peer Minority Organ Donation Education Model
    Akinlolu Ojo; Fiscal Year: 2006
    ..abstract_text> ..
  35. AFP-Based Immunotherapy for Hepatocellular Carcinoma
    Antoni Ribas; Fiscal Year: 2006
    ..In summary, I propose a clinically-oriented research program that translates this original work into novel, evidence-based immnunotherapy trials for hepatocellular carcinoma. ..
  36. Phase I Serum-free cultured thymus transplantation in DiGeorge anomaly, IND9836,
    MARY MARKERT; Fiscal Year: 2009
    ..The focus of these experiments is the development of thymopoiesis and normal presentation of promiscuously expressed antigens in the thymus. ..
  37. Antigen specific modeling of glioma immunotherapy
    Andrew Parsa; Fiscal Year: 2007
    ..The long-term goal of this proposal is to facilitate the development of Dr. Parsa into an independent investigator capable of making meaningful scientific contributions. ..
  38. mTOR Inhibition as a Therapeutic Target in Myeloma
    Sherif Farag; Fiscal Year: 2005
    ..The results of this research have important significance for the treatment of MM and may lead to a novel therapeutic approach in this disease. ..
  39. Preclinical Testing of Interleukin-7 in Primates
    Jan Storek; Fiscal Year: 2003
    ..These results will be used for the design of clinical studies. ..
  40. Inducing Immune Tolerance with Receptor Modified T Cells
    Terrence Geiger; Fiscal Year: 2003
    ..Together this information will provide a starting point for the application of GM-TCs to human immunologic conditions. ..
  41. NOVEL THERAPEUTIC STRATEGIES IN MYELODYSPLASTIC SYNDROME
    H Deeg; Fiscal Year: 2003
    ..Optimization of therapy, in turn, should reduce morbidity and mortality associated with MDS and improve the quality of life of patients with MDS. ..
  42. Innate Immune Cell Therapy with Stem Cell Transplants
    Sherif Farag; Fiscal Year: 2003
    ..The clinical and laboratory data derived from this trial will form the basis for future phase II studies to investigate the efficacy of this immunotherapy approach. ..
  43. PATHOGENESIS OF POST-TRANSPLANT BRONCHIOLITIS OBLITERANS
    Thalachallour Mohanakumar; Fiscal Year: 2004
    ..The overall goal of this proposal is to employ this unique murine preclinical model of OAD in order to define the cellular and molecular mechanism leading to BOS following clinical lung transplantation. ..
  44. EVALUATION OF A CONCEPTUAL MODEL OF ORGAN DONATION
    James Rodrigue; Fiscal Year: 2004
    ..abstract_text> ..
  45. MECHANISMS UNDERLYING GRAFT-VERSUS-HOST DISEASE
    Mary Laughlin; Fiscal Year: 2004
    ..Moreover, since NFAT1 regulates the gene expression of cytokines and immunomodulatory molecules known to mediate GVHD, their studies may reveal new therapeutic approaches to the treatment and/or prophylaxis of GVHD. ..
  46. Bone Marrow Angioblasts For Cardiac Regeneration
    Silviu Itescu; Fiscal Year: 2004
    ....
  47. CONTINUED RENOVATION OF RESEARCH BLDG
    J Streilein; Fiscal Year: 2002
    ..Once Segment 3a is accomplished, space will be available to carry out Segment 3b. At the completion of the renovation program, the Institute will have a physical facility sufficient to meet present research needs. ..
  48. Model for the Prevention of Post-Transplant Skin Cancer
    Anne Vanbuskirk; Fiscal Year: 2005
    ..This model will provide the pre-clinical basis for new clinical trials in immunosuppressed patients, who are at extremely high risk for developing life-threatening, UV-induced SCC. ..
  49. Cytokines for Immune Protection from Acute Irradiation
    George Georges; Fiscal Year: 2005
    ..The secondary endpoint is immune reconstitution. Upon study completion, we will have identified the optimal cytokine treatment and the highest dose of TBI that can be reliably survived without HSC support. ..
  50. NEWBORN GENETIC SCREENING:FOR WHOSE BENEFIT?
    Lainie Ross; Fiscal Year: 2005
    ..OUTCOMES: The major outcomes will be a series of peer-reviewed articles and a full-length book entitled Newborn Genetic Screening: In whose Interest? For whose Benefit? ..
  51. ORTHOTOPIC LIVER TRANSPLANTATION
    Thomas Starzl; Fiscal Year: 2001
    ..Moreover, the investigators will attempt to develop novel techniques to modify the number and character of the donor cells that ultimately reside in the recipient and promote tolerance to the allograft. ..
  52. GENE MODIFIED T-CELLS FOR ENGRAFTMENT AND GVHD CONTROL
    George Georges; Fiscal Year: 2003
    ..We will test if donor CTL specific for host minor histocompatibility antigens can convert mixed to complete donor chimerism. If successful this would make MHC-matched stem cell transplantation less toxic. ..
  53. Minor H Antigen Regulatory Networks as an Alternative to Calcineurin Inhibitors i
    WILLIAM BURLINGHAM; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  54. IMMUNOGENETIC MECHANISMS OF VACCINE RESPONSE
    Gregory A Poland; Fiscal Year: 2010
    ..The knowledge gained from these studies will enable us to design new strategies and new vaccines to protect human health against viral diseases. ..
  55. T AND B CELL TOLERANCE IN HUMAN MIXED CHIMERAS
    Megan Sykes; Fiscal Year: 2003
    ....
  56. Northern California Consortium for Sickle Cell Disease
    Mark Walters; Fiscal Year: 2008
    ..abstract_text> ..
  57. DONOR-DRIVEN REGULATION IN HUMAN ALLOGRAFT ACCEPTANCE
    WILLIAM BURLINGHAM; Fiscal Year: 2003
    ..Our goal is to develop a working model of how donor-derived leukocytes and the antigens they release contribute to a tonic equilibrium between host T regulator and effector cells in human allograft acceptance. ..
  58. IMMUNE REGULATION IN LUNG TRANSPLANTATION
    WILLIAM BURLINGHAM; Fiscal Year: 2003
    ..We will determine how the sensitivity, specificity, and predictive value of each test would be clinically useful in the management of lung transplant patients. ..
  59. KIDNEY TRANSPLANTATION & NON-INHERITED MATERNAL ANTIGENS
    WILLIAM BURLINGHAM; Fiscal Year: 2003
    ..Our goal is to establish the basis for a rational approach to HLA-matching and selective NIMA mismatching to achieve the goal of clinical kidney transplantation tolerance. ..
  60. Islet growth in NOD mice tolerant to autoimmune diabetes
    Kevan Herold; Fiscal Year: 2005
    ..By combining the expertise of the two Pl's to address the problems of islet autoimmunity and beta cell deficiency our proposal will test a combination strategy that may be useful in patients. ..
  61. SEPARATION OF GVH AND GVL IN MOUSE MODELS
    Megan Sykes; Fiscal Year: 2008
    ..abstract_text> ..
  62. Induction of Stable Chimerism for Sickle Cell Anemia
    Mark Walters; Fiscal Year: 2004
    ..If successful, this novel approach will expand the availability of HCT for patients with clinically significant hemoglobinopathies. ..
  63. ACTIVITY OF EXPANDED GAMMA/DELTA T CELLS
    Michael Verneris; Fiscal Year: 2005
    ..Thus, the candidate will acquire the skills to secure a faculty position as a pediatric bone marrow transplantation clinical-scientist...
  64. Immune Parameters in a Steroid Sparing Clinical Trial
    Nancy Reinsmoen; Fiscal Year: 2005
    ..Thus, the overall study is designed to use immune parameters to identify recipients at low vs. high risk for poor graft outcome, thereby allowing for individualization of immunosuppression aimed at improving long-term graft outcome. ..
  65. Combination of Anti-CD3 and Ag-Specific Immunotherapy
    Kevan Herold; Fiscal Year: 2005
    ..Furthermore, we propose that this effect of the combinatorial approach will allow us to maintain the clinical benefits by repeated administration of antigen. ..
  66. Type 1 Diabetes TrialNet: Clinical Center at Columbia University
    Kevan Herold; Fiscal Year: 2007
    ..The Center will be able to coordinate with other centers in carrying out future trials of TrialNet. ..