micronucleus tests

Summary

Summary: Induction and quantitative measurement of chromosomal damage leading to the formation of micronuclei (MICRONUCLEI, CHROMOSOME-DEFECTIVE) in cells which have been exposed to genotoxic agents or IONIZING RADIATION.

Top Publications

  1. ncbi Tradescantia micronucleus bioassay
    T H Ma
    Department of Biological Sciences, Western Illinois University, Macomb 61455
    Mutat Res 310:221-30. 1994
  2. ncbi The in vitro micronucleus technique
    M Fenech
    CSIRO Health Sciences and Nutrition, PO Box 10041, BC 5000, South Australia, Adelaide, Australia
    Mutat Res 455:81-95. 2000
  3. ncbi Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells
    M Fenech
    Department of Nutritional Genomics and DNA Damage Diagnostics, Commonwealth Scientific and Industrial Research Organisation Food and Nutritional Sciences, Gate 13 Kintore Avenue, PO Box 10041, Adelaide BC, South Australia 5000, Australia
    Mutagenesis 26:125-32. 2011
  4. ncbi Micronuclei frequency in peripheral blood lymphocytes and cancer risk: evidence from human studies
    Stefano Bonassi
    Unit of Clinical and Molecular Epidemiology, IRCCS San Raffaele Pisana, 00166 Rome, Italy
    Mutagenesis 26:93-100. 2011
  5. ncbi Cytokinesis-block micronucleus cytome assay
    Michael Fenech
    Genome Health Nutrigenomics Laboratory, CSIRO Human Nutrition, Food Science Australia, PO Box 10041, Adelaide 5000, South Australia, Australia
    Nat Protoc 2:1084-104. 2007
  6. ncbi Twenty-eight-day oral toxicity, genotoxicity, and gender-related tissue distribution of silver nanoparticles in Sprague-Dawley rats
    Yong Soon Kim
    Korea Environment and Merchandise Testing Institute, Incheon, Korea
    Inhal Toxicol 20:575-83. 2008
  7. ncbi HUMN project: detailed description of the scoring criteria for the cytokinesis-block micronucleus assay using isolated human lymphocyte cultures
    M Fenech
    CSIRO Health Sciences and Nutrition, Adelaide, SA, Australia
    Mutat Res 534:65-75. 2003
  8. ncbi The HUman MicroNucleus project on eXfoLiated buccal cells (HUMN(XL)): the role of life-style, host factors, occupational exposures, health status, and assay protocol
    Stefano Bonassi
    Unit of Clinical and Molecular Epidemiology, IRCCS San Raffaele Pisana, Via di Val Cannuta, Roma, Italy
    Mutat Res 728:88-97. 2011
  9. ncbi An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans
    Stefano Bonassi
    Unit of Molecular Epidemiology, National Cancer Research Institute, Genoa, Italy
    Carcinogenesis 28:625-31. 2007
  10. ncbi The in vitro MN assay in 2011: origin and fate, biological significance, protocols, high throughput methodologies and toxicological relevance
    Micheline Kirsch-Volders
    Laboratorium voor Cellulaire Genetica, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium
    Arch Toxicol 85:873-99. 2011

Research Grants

  1. Measuring Cytogenetic Damage in Human Blood
    Stephen Dertinger; Fiscal Year: 2003
  2. Automation of the vitro Micronucleus Assay
    Stephen Dertinger; Fiscal Year: 2004
  3. In vivo mutation assay based on pig-a locus
    Stephen Dertinger; Fiscal Year: 2004
  4. Rapid Screen for Genotoxicants, Chemoprotectors, and Radioprotectors
    Stephen Dertinger; Fiscal Year: 2008
  5. High Throughput Radiation Biodosimetry
    Stephen Dertinger; Fiscal Year: 2007
  6. Versatile Mutation Assay Platform
    Stephen Dertinger; Fiscal Year: 2007
  7. Molecular Biomarkers as Predictors of Hodgkin's Disease
    Randa El Zein; Fiscal Year: 2007
  8. PON1 and Developmental Sensitivity to OP Pesticides
    Nina T Holland; Fiscal Year: 2010
  9. Flow Cytometric Method to Analyze Micronuclei
    Dorothea Torous; Fiscal Year: 2002
  10. Assessing toxicity with an ex vivo erythropoiesis system
    Dorothea Torous; Fiscal Year: 2003

Detail Information

Publications274 found, 100 shown here

  1. ncbi Tradescantia micronucleus bioassay
    T H Ma
    Department of Biological Sciences, Western Illinois University, Macomb 61455
    Mutat Res 310:221-30. 1994
    ..It is suitable for the rapid screening of chemicals, and also is specially qualified for in situ monitoring of ambient pollutants...
  2. ncbi The in vitro micronucleus technique
    M Fenech
    CSIRO Health Sciences and Nutrition, PO Box 10041, BC 5000, South Australia, Adelaide, Australia
    Mutat Res 455:81-95. 2000
    ..The basic principles and methods (including detailed scoring criteria for all the genotoxicity and cytotoxicity end-points) of the CBMN assay are described and areas for future development identified...
  3. ncbi Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells
    M Fenech
    Department of Nutritional Genomics and DNA Damage Diagnostics, Commonwealth Scientific and Industrial Research Organisation Food and Nutritional Sciences, Gate 13 Kintore Avenue, PO Box 10041, Adelaide BC, South Australia 5000, Australia
    Mutagenesis 26:125-32. 2011
    ..NBUD represent the process of elimination of amplified DNA, DNA repair complexes and possibly excess chromosomes from aneuploid cells...
  4. ncbi Micronuclei frequency in peripheral blood lymphocytes and cancer risk: evidence from human studies
    Stefano Bonassi
    Unit of Clinical and Molecular Epidemiology, IRCCS San Raffaele Pisana, 00166 Rome, Italy
    Mutagenesis 26:93-100. 2011
    ..However, issues such as interindividual variability and preventive strategies in high-risk groups need to be further addressed to consolidate these achievements...
  5. ncbi Cytokinesis-block micronucleus cytome assay
    Michael Fenech
    Genome Health Nutrigenomics Laboratory, CSIRO Human Nutrition, Food Science Australia, PO Box 10041, Adelaide 5000, South Australia, Australia
    Nat Protoc 2:1084-104. 2007
    ..The procedure can take up to 5 days to complete...
  6. ncbi Twenty-eight-day oral toxicity, genotoxicity, and gender-related tissue distribution of silver nanoparticles in Sprague-Dawley rats
    Yong Soon Kim
    Korea Environment and Merchandise Testing Institute, Incheon, Korea
    Inhal Toxicol 20:575-83. 2008
    ..In particular, a gender-related difference in the accumulation of silver was noted in the kidneys, with a twofold increase in the female kidneys when compared with the male kidneys...
  7. ncbi HUMN project: detailed description of the scoring criteria for the cytokinesis-block micronucleus assay using isolated human lymphocyte cultures
    M Fenech
    CSIRO Health Sciences and Nutrition, Adelaide, SA, Australia
    Mutat Res 534:65-75. 2003
    ....
  8. ncbi The HUman MicroNucleus project on eXfoLiated buccal cells (HUMN(XL)): the role of life-style, host factors, occupational exposures, health status, and assay protocol
    Stefano Bonassi
    Unit of Clinical and Molecular Epidemiology, IRCCS San Raffaele Pisana, Via di Val Cannuta, Roma, Italy
    Mutat Res 728:88-97. 2011
    ....
  9. ncbi An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans
    Stefano Bonassi
    Unit of Molecular Epidemiology, National Cancer Research Institute, Genoa, Italy
    Carcinogenesis 28:625-31. 2007
    ..The current wide-spread use of the MN assay provides a valuable opportunity to apply this assay in the planning and validation of cancer surveillance and prevention programs...
  10. ncbi The in vitro MN assay in 2011: origin and fate, biological significance, protocols, high throughput methodologies and toxicological relevance
    Micheline Kirsch-Volders
    Laboratorium voor Cellulaire Genetica, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium
    Arch Toxicol 85:873-99. 2011
    ..Implementation of in vitro MN assays in the test battery for hazard and risk assessment of potential mutagens/carcinogens is therefore fully justified...
  11. ncbi Cytogenetic and oxidative damage induced in human lymphocytes by platinum, rhodium and palladium compounds
    Lucia Migliore
    Dipartimento di Scienze dell Uomo e dell Ambiente, University of Pisa, Via S Giuseppe 22, 56126 Pisa, Italy
    Mutagenesis 17:411-7. 2002
    ..This work highlights the stronger genotoxicity, likely mediated by oxidative damage induction, of Pt and Rh compounds compared with Pd salts...
  12. ncbi HUman MicroNucleus project: international database comparison for results with the cytokinesis-block micronucleus assay in human lymphocytes: I. Effect of laboratory protocol, scoring criteria, and host factors on the frequency of micronuclei
    S Bonassi
    Department of Environmental Epidemiology, Istituto Nazionale per la Ricerca sul Cancro, 10 Largo R Benzi, Genoa I 16132, Italy
    Environ Mol Mutagen 37:31-45. 2001
    ..Our best model, which included exposure to genotoxic factors, host factors, methods, and scoring criteria, explained 75% of the total variance, with the largest contribution attributable to laboratory methods...
  13. ncbi Cytokinesis-blocked micronucleus assay and cancer risk assessment
    Randa El-Zein
    Department of Epidemiology, Division of Cancer Prevention and Population Sciences, 1155 Pressler Street, Unit 1340, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mutagenesis 26:101-6. 2011
    ....
  14. ncbi Micronucleus and its applications
    Swapan Samanta
    Department of Pathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
    Diagn Cytopathol 40:84-90. 2012
    ..In this brief review, the morphology, etiology, estimation, and applications of MN have been discussed...
  15. ncbi Genotoxic effects of silver nanoparticles stimulated by oxidative stress in human normal bronchial epithelial (BEAS-2B) cells
    Ha Ryong Kim
    School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi Do, South Korea
    Mutat Res 726:129-35. 2011
    ..These results suggest that Ag-NPs have genotoxic effects in BEAS-2B cells and that oxidative stress stimulated by Ag-NPs may be an important factor in their genotoxic effects...
  16. ncbi Chemical induction of the bystander effect in normal human lymphoblastoid cells
    Rajalakshmi S Asur
    Department of Biological Sciences, Wayne State University, Detroit, MI 48202 3917, USA
    Mutat Res 676:11-6. 2009
    ..We conclude that the bystander effect is not restricted to ionizing radiation, suggesting it may be a part of a general cellular stress response...
  17. ncbi Association of micronucleus frequency with neurodegenerative diseases
    Lucia Migliore
    Department of Human and Environmental Sciences, University of Pisa, Via S Giuseppe 22, 56126 Pisa, Italy
    Mutagenesis 26:85-92. 2011
    ..These changes in buccal cytome ratios may prove useful as potential future diagnostics to identify individuals of increased risk for these disorders...
  18. ncbi The micronucleus assay in human buccal cells as a tool for biomonitoring DNA damage: the HUMN project perspective on current status and knowledge gaps
    Nina Holland
    School of Public Health, University of California, Berkeley, CA 94720 7460, USA
    Mutat Res 659:93-108. 2008
    ....
  19. ncbi Liver tumor-promoting activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in TCDD-sensitive and TCDD-resistant rat strains
    M Viluksela
    Laboratory of Toxicology, National Public Health Institute, Kuopio, Finland
    Cancer Res 60:6911-20. 2000
    ..Understanding the role of transactivation domain of the aryl hydrocarbon receptor in carcinogenesis is therefore likely to improve dioxin risk assessment...
  20. ncbi Cytogenetic damage in buccal epithelia and peripheral lymphocytes of young healthy individuals exposed to ozone
    Connie Chen
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, 94720 7360, USA
    Mutagenesis 21:131-7. 2006
    ..p.b. O(3). This cytogenetic evidence, along with recent studies linking O(3) exposure to elevated lung cancer risk and mortality, suggest potential public health implications from exposures to high oxidant environments...
  21. ncbi The micronucleus assay as a biological dosimeter of in vivo ionising radiation exposure
    Anne Vral
    Department of Basic Medical Sciences, Ghent University, De Pintelaan 185, 9000 Gent, Belgium
    Mutagenesis 26:11-7. 2011
    ..The development of a combined automated MN-centromere scoring procedure remains a challenge for the future, as it will allow systematic biomonitoring of radiation workers exposed to low-dose radiation...
  22. ncbi Genotoxic and cytotoxic potential of titanium dioxide (TiO2) nanoparticles on fish cells in vitro
    William F Vevers
    Ecotoxicology and Stress Biology Research Centre, School of Biological Sciences, University of Plymouth, Plymouth PL4 8AA, UK
    Ecotoxicology 17:410-20. 2008
    ....
  23. ncbi Cytokinesis-block micronucleus cytome assay in lymphocytes
    Philip Thomas
    CSIRO Human Nutrition, Adelaide, SA, Australia
    Methods Mol Biol 682:217-34. 2011
    ..This protocol also describes the current established methods for culturing lymphocytes, slide preparation, cellular and nuclear staining, scoring criteria, data recording, and analyses...
  24. ncbi Relationships among micronuclei, nucleoplasmic bridges and nuclear buds within individual cells in the cytokinesis-block micronucleus assay
    Han S J Cheong
    Department of Biological Sciences, 5047 Gullen Mall, Wayne State University, Detroit, MI 48202 3917, USA
    Mutagenesis 28:433-40. 2013
    ....
  25. ncbi Report on the buccal micronucleus assay workshop organized by the International Human Micronucleus (HUMN) project--Antalya, Turkey 2007
    Michael Fenech
    Mutagenesis 24:199-201. 2009
    ..A follow-up workshop is planned at the 10th International Conference on Environmental Mutagens in Florence in 2009...
  26. ncbi The micronucleus assay in radiation accidents
    Hubert Thierens
    Department of Basic Medical Sciences, Faculty of Medicine, University of Ghent, Belgium
    Ann Ist Super Sanita 45:260-4. 2009
    ..Automated scoring of micronuclei in combination with centromere signals, allowing systematic biodosimetry of exposed populations, remains a challenge for the future...
  27. ncbi A protocol for the in vitro micronucleus test. II. Contributions to the validation of a protocol suitable for regulatory submissions from an examination of 10 chemicals with different mechanisms of action and different levels of activity
    J Barry Phelps
    Toxicology Division, Lilly Research Laboratories, A Division of Eli Lilly and Company, 2001 West Main Street, Greenfield, IN 46140, USA
    Mutat Res 521:103-12. 2002
    ....
  28. ncbi Assessment of DNA damage in peripheral blood of heavy smokers with the comet assay and the micronucleus test
    Heike Hoffmann
    Universitatsklinikum Ulm, Abteilung Humangenetik, D 89070 Ulm, Germany
    Mutat Res 581:105-14. 2005
    ..Baseline and gamma radiation-induced micronucleus frequencies were determined. None of these approaches revealed a significant difference between heavy smokers and non-smokers with regard to a genotoxic effect in peripheral blood cells...
  29. ncbi Can carcinogenic potency be predicted from in vivo genotoxicity data?: a meta-analysis of historical data
    Lya G Hernandez
    Laboratory of Health Protection Research, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Environ Mol Mutagen 52:518-28. 2011
    ..Experimental designs of genotoxicity assays need to shift from focusing only on hazard identification where positive and negative results are reported, to a more quantitative, dose-response assessment...
  30. ncbi Mechanistic investigations of low dose exposures to the genotoxic compounds bisphenol-A and rotenone
    George E Johnson
    Institute of Life Science, School of Medicine, Swansea University, Singleton Park, Swansea SA2 8PP, Wales, UK
    Mutat Res 651:56-63. 2008
    ..The similarity in concentration inducing tripolar mitosis, M.I. and MN changes suggests immunofluorescence analysis to be a useful dose setting assay with emphasis on the mechanism...
  31. ncbi Ultrafine titanium dioxide particles in the absence of photoactivation can induce oxidative damage to human bronchial epithelial cells
    Jia Ran Gurr
    Department of Tourism, Hsing Wu College, No 11 2 Fen Liao Road, Linkou, Taipei, Taiwan 24452, ROC
    Toxicology 213:66-73. 2005
    ..These results suggest that intratracheal instillation of ultrafine TiO(2) particles may cause an inflammatory response...
  32. ncbi Micronucleus assay in aquatic animals
    Claudia Bolognesi
    Environmental Carcinogenesis Unit, National Institute for Research on Cancer, Largo Rosanna Benzi 10, 16132 Genoa, Italy
    Mutagenesis 26:205-13. 2011
    ..Further validation studies are needed in order to better characterise the different types of nuclear alterations and to clarify the role of biotic and abiotic factors in interspecies and inter-individual variability...
  33. ncbi Micronuclei and their association with sperm abnormalities, infertility, pregnancy loss, pre-eclampsia and intra-uterine growth restriction in humans
    Michael Fenech
    CSIRO Food and Nutritional Sciences, Gate 13, Kintore Avenue, Adelaide SA 5000, Australia
    Mutagenesis 26:63-7. 2011
    ..In conclusion, more attention should be given to the possibility of using MN assays in peripheral blood lymphocytes and reproductive tissues as a biomarker of risk for infertility and pregnancy complications in humans...
  34. ncbi The association of micronucleus frequency with obesity, diabetes and cardiovascular disease
    Maria Grazia Andreassi
    GENETICS RESEARCH UNIT, Institute of Clinical Physiology, Italian National Research Council, Via Moruzzi 1, 56126 Pisa, Italy
    Mutagenesis 26:77-83. 2011
    ..Large population-based cohorts are needed in order to compare the MN frequencies as well as to better define whether MN is a biomarker or a mediator of cardiometabolic diseases...
  35. ncbi Transient increase in micronucleus frequency and DNA effects in the comet assay in two patients after intoxication with 2,3,7,8-tetrachlorodibenzo- p-dioxin
    Eva Valic
    Clinical Department of Occupational Medicine, University of Vienna, Waehringer Guertel 18 20, Vienna, Austria
    Int Arch Occup Environ Health 77:301-6. 2004
    ..The genotoxic effects in two patients with 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) intoxication were measured; an association with the workplace was suspected...
  36. ncbi Automated micronucleus (MN) scoring for population triage in case of large scale radiation events
    Petra Willems
    Department of Basic Medical Sciences, Ghent University, Ghent, Belgium
    Int J Radiat Biol 86:2-11. 2010
    ..The aim of our study was to develop a quick population triage method based on automated micronucleus (MN) scoring...
  37. ncbi Origin of nuclear buds and micronuclei in normal and folate-deprived human lymphocytes
    Hanna K Lindberg
    New Technologies and Risks, Work Environment Development, Finnish Institute of Occupational Health, Topeliuksenkatu 41aA, FI 00250 Helsinki, Finland
    Mutat Res 617:33-45. 2007
    ....
  38. pmc Pre-exposure to 50 Hz magnetic fields modifies menadione-induced genotoxic effects in human SH-SY5Y neuroblastoma cells
    Jukka Luukkonen
    Department of Environmental Science, University of Eastern Finland, Kuopio, Finland
    PLoS ONE 6:e18021. 2011
    ..In the present study, we examined whether pre-exposure to ELF MF affects chemically induced DNA damage level, DNA repair rate, or micronucleus frequency in human SH-SY5Y neuroblastoma cells...
  39. pmc Preliminary biocompatibility investigation of magnetic albumin nanosphere designed as a potential versatile drug delivery system
    Luciana Estevanato
    Instituto de Ciencias Biologicas, Universidade de Brasilia, 70910 900, Brasilia DF, Brazil
    Int J Nanomedicine 6:1709-17. 2011
    ..It is noteworthy that MAN was efficient in treating Ehrlich's tumors by the magnetohyperthermia procedure...
  40. ncbi Chromosomal radiosensitivity in BRCA1 and BRCA2 mutation carriers
    A Baeyens
    Department of Anatomy, Embryology, Histology and Medical Physics, Ghent University, L Pasteurlaan 2, B 9000 Gent, Belgium
    Int J Radiat Biol 80:745-56. 2004
    ....
  41. ncbi Cytogenetic observations in human peripheral blood leukocytes following in vitro exposure to THz radiation: a pilot study
    O Zeni
    Interuniversity Center on Interaction between Electromagnetic Fields and Biosystems ICEmB at CNR IREA, Via Diocleziano 328 80124 Napoli, Italy
    Health Phys 92:349-57. 2007
    ..The results obtained indicate that THz exposure, in the explored electromagnetic conditions, is not able to induce either genotoxicity or alteration of cell cycle kinetics in human blood cells from healthy subjects...
  42. ncbi Insensitivity of the in vitro cytokinesis-block micronucleus assay with human lymphocytes for the detection of DNA damage present at the start of the cell culture
    Günter Speit
    Universitat Ulm, Institut fur Humangenetik, D 89069 Ulm, Germany
    Mutagenesis 27:743-7. 2012
    ..Potential consequences for the interpretation of human biomonitoring studies are discussed in this article...
  43. ncbi Genotoxic effects of occupational exposure to lead and cadmium
    J Palus
    Department of Toxicology and Carcinogenesis, Nofer Institute of Occupational Medicine, Lodz, Poland
    Mutat Res 540:19-28. 2003
    ..Our findings indicate that lead and cadmium induce clastogenic as well as aneugenic effects in peripheral lymphocytes, indicating a potential health risk for working populations with significant exposures to these heavy metals...
  44. ncbi Genetic susceptibility of newborn daughters to oxidative stress
    Ilse Decordier
    Laboratory of Cell Genetics, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium
    Toxicol Lett 172:68-84. 2007
    ..However, these conclusions might not be extrapolable to other types of DNA damage and need confirmation in a study on a larger population...
  45. ncbi Use of the micronucleus assay with exfoliated epithelial cells as a biomarker for monitoring individuals at elevated risk of genetic damage and in chemoprevention trials
    B J Majer
    Institute for Cancer Research of the University of Vienna, Environmental Toxicology Group, Borschkegasse 8a, A 1090, Vienna, Austria
    Mutat Res 489:147-72. 2001
    ..However, the current data base is not sufficient to draw a firm conclusion on the specificity of this approach...
  46. ncbi Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens I. Sensitivity, specificity and relative predictivity
    David Kirkland
    Covance Laboratories Limited, Otley Road, Harrogate HG3 1PY, UK
    Mutat Res 584:1-256. 2005
    ..This RP measure is considered a useful tool for industry to assess the likelihood of a chemical possessing carcinogenic potential from batteries of positive or negative results...
  47. pmc Biomonitoring of complex occupational exposures to carcinogens: the case of sewage workers in Paris
    Hamzeh Al Zabadi
    INSERM ERI 11, Nancy University Medical School, 9 Av de la Foret de Haye, BP 184, 54505 Vandoeuvre Les Nancy Cedex, France
    BMC Cancer 8:67. 2008
    ..Thus, trying to relate adverse outcomes to single toxicant is inappropriate. We aim to investigate if sewage workers are at increased carcinogenic risk as evaluated by biomarkers of exposure and early biological effects...
  48. ncbi Relation of increased chromosomal damage to future adverse cardiac events in patients with known coronary artery disease
    Chiara Federici
    CNR, Institute of Clinical Physiology, Gabriele Monasterio Foundation, Massa, Italy
    Am J Cardiol 102:1296-300. 2008
    ..2, 95% confidence interval 1.1 to 4.7, p = 0.03). In conclusion, levels of peripheral chromosomal DNA damage may be a new sensitive biomarker of prognostic stratification in patients with known CAD...
  49. ncbi Safety studies on epigallocatechin gallate (EGCG) preparations. Part 1: genotoxicity
    R A Isbrucker
    Burdock Group, 888 17th St NW Suite 810, Washington, DC 20006, USA
    Food Chem Toxicol 44:626-35. 2006
    ..The intravenous injection of 10, 25 and 50 mg EGCG/kg/day to rats resulted in much higher plasma concentrations and demonstrated an absence of genotoxic effects. From these studies, it is concluded that Teavigo (EGCG) is not genotoxic...
  50. pmc Comparative study of Domoic Acid and Okadaic Acid induced-chromosomal abnormalities in the Caco-2 cell line
    Pinto Silva Carvalho
    Department of Environmental Engineering, Toxicological Laboratory of the Federal University of Santa Catarina, Brazil Campus Universitário, Trindade 88040 900, Brazil
    Int J Environ Res Public Health 3:4-10. 2006
    ....
  51. pmc Comparative study of the clastogenicity of functionalized and nonfunctionalized multiwalled carbon nanotubes in bone marrow cells of Swiss-Webster mice
    Anita K Patlolla
    Molecular Toxicology Research Laboratory, NIH RCMI Center for Environmental Health, Jackson State University, 1400 Lynch Street, Box 18540, Jackson, Mississippi 39217, USA
    Environ Toxicol 25:608-21. 2010
    ..Hence, careful monitoring should be done with respect to designing/synthesizing biocompatible carbon nanomaterials. Further characterization of their systemic toxicity, genotoxicity and carcinogenicity is also essential...
  52. ncbi Detection and characterization of mechanisms of action of aneugenic chemicals
    E M Parry
    Centre for Molecular Genetics and Toxicology, School of Biological Sciences, University of Wales Swansea, Singleton Park, Swansea SA2 8PP, UK
    Mutagenesis 17:509-21. 2002
    ..Both types of modifications lead to the induction of aneuploidy in exposed cells. Our studies also implicate the products of the p53 and XPD genes in the regulation of the fidelity of chromosome segregation at mitosis...
  53. ncbi The HUman MicroNucleus Project--An international collaborative study on the use of the micronucleus technique for measuring DNA damage in humans
    M Fenech
    CSIRO Human Nutrition, Gouger Street, P O Box 10041, Adelaide, Australia
    Mutat Res 428:271-83. 1999
    ....
  54. ncbi Evaluation of genetic damage in Brazilian footwear-workers: biomarkers of exposure, effect, and susceptibility
    Vanina Dahlström Heuser
    Postgraduate Programme in Genetics and Molecular Biology PPGGBM, Federal University of Rio Grande do Sul UFRGS, Porto Alegre RS, Brazil
    Toxicology 232:235-47. 2007
    ..006, f=5.876)...
  55. pmc Elevated levels of urinary 8-hydroxy-2 -deoxyguanosine, lymphocytic micronuclei, and serum glutathione S-transferase in workers exposed to coke oven emissions
    Ai Lin Liu
    Department of Occupational and Environmental Health and Ministry of Education Key Lab for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Environ Health Perspect 114:673-7. 2006
    ..The consequences of the changes in these biomarkers, such as risk of cancer, warrant further investigations...
  56. ncbi The antigenotoxic activities of cactus (Opuntia ficus-indica) cladodes against the mycotoxin zearalenone in Balb/c mice: prevention of micronuclei, chromosome aberrations and DNA fragmentation
    Lazhar Zorgui
    Research Unit of Macromolecular Biochemistry and Genetics, Faculty of Sciences of Gafsa, 2112 Gafsa, Tunisia
    Food Chem Toxicol 47:662-7. 2009
    ..This could be relevant, particularly with the emergent demand for natural products which may neutralize the genotoxic effects of the multiple food contaminants...
  57. ncbi In vitro biosynthesis and genotoxicity bioassay of silver nanoparticles using plants
    Kamal K Panda
    Molecular Biology and Genomics Laboratory, Department of Botany, Berhampur University, Berhampur 760 007, India
    Toxicol In Vitro 25:1097-105. 2011
    ..The present findings demonstrated the role of ROS in the AgNP-induced cell death and DNA damage...
  58. ncbi Evaluation of the genotoxicity of zerumbone in cultured human peripheral blood lymphocytes
    Adel S Al-Zubairi
    Laboratory of Cancer Research MAKNA UPM, Institute of Biosciences, University Putra Malaysia, Serdang, 43400 Selangor DE, Malaysia
    Toxicol In Vitro 24:707-12. 2010
    ..The overall clastogenic effect of ZER on human PBL was statistically not significant. In conclusion, ZER is a cytotoxic but not a clastogenic substance in human PBL...
  59. pmc Radiation-induced micronucleus induction in lymphocytes identifies a high frequency of radiosensitive cases among breast cancer patients: a test for predisposition?
    D Scott
    Paterson Institute for Cancer Research, Christie CRC Research Centre, Manchester, UK
    Br J Cancer 77:614-20. 1998
    ..In the long term, such cytogenetic assays may have the potential for selecting women for intensive screening for breast cancer...
  60. ncbi The improved Allium/Vicia root tip micronucleus assay for clastogenicity of environmental pollutants
    T H Ma
    Department of Biological Sciences, Western Illinois University, Macomb 61455, USA
    Mutat Res 334:185-95. 1995
    ..The greater sensitivity of the Allium roots is probably due to the greater total length of the diploid complement and the higher number of metacentric chromosomes.(ABSTRACT TRUNCATED AT 400 WORDS)..
  61. ncbi Aneugenic potential of the nitrogen mustard analogues melphalan, chlorambucil and p-N,N-bis(2-chloroethyl)aminophenylacetic acid in cell cultures in vitro
    M Efthimiou
    Division of Genetics, Cell and Developmental Biology, Department of Biology, University of Patras, Patras 265 00, Greece
    Mutat Res 617:125-37. 2007
    ..Further studies are warranted to clarify the above two hypotheses...
  62. pmc Epigenetic programming in the preimplantation rat embryo is disrupted by chronic paternal cyclophosphamide exposure
    Tara S Barton
    Departments of Pharmacology and Therapeutics and Obstetrics and Gynecology, McGill University, 3655 Promenade Sir William Osler, Montreal, QC, Canada H3G 1Y6
    Proc Natl Acad Sci U S A 102:7865-70. 2005
    ..We hypothesize that disturbances in epigenetic programming contribute to heritable instabilities later in development, emphasizing the importance of epigenetic risk assessment after chemotherapy...
  63. ncbi Exogenous carbon monoxide protects the bystander Chinese hamster ovary cells in mixed coculture system after alpha-particle irradiation
    Wei Han
    Department of Physics and Materials Science, City University of Hong Kong, Kowloon Tong, Hong Kong
    Carcinogenesis 31:275-80. 2010
    ..Considering the inhibitory effect of CO on RIBE and the wide use of CO in therapy of diseases, it is hoped that a low concentration of CO can protect normal tissues against RIBE during radiotherapy...
  64. ncbi Heritability of baseline and induced micronucleus frequencies
    Harald Surowy
    Institute of Human Genetics, University Hospital Ulm, Ulm, Germany
    Mutagenesis 26:111-7. 2011
    ....
  65. ncbi Molecular analysis of genetic instability caused by chronic inflammation
    Bin Yan
    Department of Radiation Oncology, Virginia Commonwealth University Health System, Richmond, VA, USA
    Methods Mol Biol 512:15-28. 2009
    ..Therefore, genetic instability plays an important role in inflammation-associated cancers...
  66. ncbi Assessment of the in vitro and in vivo genotoxic and antigenotoxic effects of pimaradienoic acid in mammalian cells
    Fabiana Hibary Kato
    Universidade de Franca, Franca, Sao Paulo, Brazil
    Mutat Res 749:87-92. 2012
    ..Furthermore, PA significantly reduced the frequency of DXR- and MMS-induced micronuclei and extent of DNA damage in in vitro and in vivo test systems...
  67. ncbi Use of the cytokinesis-block micronucleus assay to measure radiation-induced chromosome damage in lymphoblastoid cell lines
    Sara Gutierrez-Enriquez
    DNA Repair Group, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Mutat Res 535:1-13. 2003
    ..In conclusion, our results show that the use of Cyt-B increases the sensitivity of the MN test for comparing differences in radiosensitivity between lymphoblastoid cell lines...
  68. ncbi Effect of chlorophyllin on chromium trioxide-induced micronuclei in polychromatic erythrocytes in mouse peripheral blood
    M C Garcia-Rodriguez
    Laboratorio de Citogenetica, Mutagénesis y Toxicología Reproductiva, UIBR, Facultad de Estudios Superiores Zaragoza, UNAM, A P 9 020, 15000, D F, Mexico City, Mexico
    Mutat Res 496:145-51. 2001
    ....
  69. ncbi Kinetics of micronucleus induction and cytotoxic activity of colchicine in murine erythroblast in vivo
    T Vallarino-Kelly
    , Instituto Nacional de Investigaciones Nucleares, Apartado Postal 18-1027 Mexico D.F, Mexico
    Mutat Res 495:51-9. 2001
    ..These data imply that low doses of colchicine are slightly cytotoxic, and that under this circumstances colchicines arrives rapidly to hemopoyetic tissues and acts for several hours...
  70. ncbi Radiobiological characteristics of solid tumours depending on the p53 status of the tumour cells, with emphasis on the response of intratumour quiescent cells
    S Masunaga
    Radiation Oncology Research Laboratory, Research Reactor Institute, Kyoto University, Noda, Kumatori cho, Sennan gun, Osaka 590 0494, Japan
    Eur J Cancer 38:718-27. 2002
    ..From the viewpoint of tumour control as a whole, including intratumour Q tumour cell control, a treatment modality for enhancing the Q cell response has to be considered...
  71. ncbi Cytogenetic biodosimetry of an accidental exposure of a radiological worker using multiple assays
    H Thierens
    Department of Anatomy, Embryology, Histology and Medical Physics, University Ghent, Proeftuinstraat 86, B 9000 Gent, Belgium
    Radiat Prot Dosimetry 113:408-14. 2005
    ....
  72. ncbi Allium cepa chromosome aberration and micronucleus tests applied to study genotoxicity of extracts from pesticide-treated vegetables and grapes
    D Feretti
    Department of Experimental and Applied Medicine, University of Brescia, Viale Europa, Brescia, Italy
    Food Addit Contam 24:561-72. 2007
    ..Allium cepa tests proved to be sensitive in monitoring genotoxicity in food extracts. The micronucleus test in interphase cells gave a much higher mutagenicity than the chromosomal aberration test in anaphase-telophase cells...
  73. ncbi A core in vitro genotoxicity battery comprising the Ames test plus the in vitro micronucleus test is sufficient to detect rodent carcinogens and in vivo genotoxins
    David Kirkland
    Kirkland Consulting, PO Box 79, Tadcaster LS24 0AS, United Kingdom
    Mutat Res 721:27-73. 2011
    ..Thus, there is no convincing evidence that any genotoxic rodent carcinogens or in vivo genotoxins would remain undetected in an in vitro test battery consisting of Ames+MNvit...
  74. ncbi Investigation on the protective effects of cranberry against the DNA damage induced by benzo[a]pyrene
    Eduardo Madrigal-Santillán
    Institute of Health Sciences, Autonomous University of Hidalgo State, Ex Hacienda de la Concepción Pachuca, Hidalgo, 42080, Mexico
    Molecules 17:4435-51. 2012
    ..Our results suggest that the inhibition of clastogenicity of the cranberry ethanolic extract against B[a]P is related to the antioxidant capacity of the combination of phytochemicals present in its chemical composition...
  75. ncbi Bystander effect induced by counted high-LET particles in confluent human fibroblasts: a mechanistic study
    Chunlin Shao
    Heavy Ion Radiobiology Research Group, National Institute of Radiological Sciences, Inage, Chiba 263 8555, Japan
    FASEB J 17:1422-7. 2003
    ..Accordingly, both ROS and GJIC contribute to the above-mentioned bystander response and GJIC may play an essential role by mediating the release of soluble biochemical factors from targeted cells...
  76. ncbi Genotoxicity and cytotoxicity of multi-wall carbon nanotubes in cultured Chinese hamster lung cells in comparison with chrysotile A fibers
    Masumi Asakura
    Japan Bioassay Research Center, Japan Industrial Safety and Health Association, 2445 Hirasawa, Hadano, Kanagawa, Japan
    J Occup Health 52:155-66. 2010
    ..The present study was designed to examine the in vitro cytotoxicity and genotoxicity of MWCNT and UICC chrysotile A (chrysotile)...
  77. ncbi Aneugenic potential of okadaic acid revealed by the micronucleus assay combined with the FISH technique in CHO-K1 cells
    Ludovic Le Hegarat
    AFSSA, Laboratoire d Etudes et de Recherches sur les Médicaments Vétérinaires et les Désinfectants, Unité de Toxicologie Alimentaire, BP 90203, F 35302 Fougères, France
    Mutagenesis 18:293-8. 2003
    ..The relationship between the different components involved in the mitotic process and OA inhibition of protein phosphatase is also discussed...
  78. ncbi SFTG international collaborative study on in vitro micronucleus test II. Using human lymphocytes
    M Gillian Clare
    Department of Genetic Toxicology, Safety Assessment, Astra Charnwood, Loughborough, Leics, UK
    Mutat Res 607:37-60. 2006
    ....
  79. ncbi Cytogenetic monitoring of hospital workers occupationally exposed to ionizing radiation using the micronucleus centromere assay
    H Thierens
    Department of Biomedical Physics and Radiation Protection, University of Ghent, Proeftuinstraat 86, Ghent, Belgium
    Mutagenesis 15:245-9. 2000
    ..The results obtained indicate that in contrast to the predominantly clastogenic action of acute exposure to ionizing radiation, the aneugenic properties of radiation may be important after long-term chronic low dose exposure...
  80. ncbi DNA damage and repair in lymphocytes of normal individuals and cancer patients: studies by the comet assay and micronucleus tests
    Olena Palyvoda
    Institute of Cell Biology, National Academy of Sciences, Lviv, Ukraine
    Acta Biochim Pol 50:181-90. 2003
    ..Lymphocytes of donors belonging to this subgroup showed significantly lower inhibition of cell cycle after irradiation...
  81. ncbi Reflections on the development of micronucleus assays
    John A Heddle
    Department of Biology, York University, Toronto, Ontario M3J 1P3, Canada
    Mutagenesis 26:3-10. 2011
    ..Although this is by no means a complete history, those working in the field may be interested in some of the personal events that lie behind the development and acceptance of methods that are now standard...
  82. ncbi Marine invertebrate eco-genotoxicology: a methodological overview
    David R Dixon
    Southampton Oceanography Centre, Waterfront Campus, European Way, Southampton SO14 3ZH, UK
    Mutagenesis 17:495-507. 2002
    ..It concludes with the recommendation for the adoption of standardized test procedures, leading to a tiered approach in future eco-genotoxicity testing...
  83. pmc Genotoxic potential generated by biomass burning in the Brazilian Legal Amazon by Tradescantia micronucleus bioassay: a toxicity assessment study
    Herbert A Sisenando
    Escola Nacional de Saúde Pública ENSP, FIOCRUZ, Rio de Janeiro, CEP 21041 210, RJ, Brazil
    Environ Health 10:41. 2011
    ..The aim of this study was to assess the genotoxic potential of the atmosphere in the Tangará da Serra region, using Tradescantia pallida as in situ bioindicator...
  84. ncbi Genomic instability in Down syndrome and Fanconi anemia assessed by micronucleus analysis and single-cell gel electrophoresis
    S W Maluf
    Medical Genetics Service, Hospital de Clinicas, Rua Ramiro Barcelos, 2350, 90035 003, Porto Alegre, Brazil
    Cancer Genet Cytogenet 124:71-5. 2001
    ..While the damage measured by micronucleus analysis is accumulated over a long period of time, DNA damage measured by SCGE reflects recent, unrepaired events...
  85. ncbi Micronuclei in peripheral blood from patients after cytostatic therapy mainly arise ex vivo from persistent damage
    Nicole Sibel Arsoy
    Institut fur Humangenetik, Universitat Ulm, Germany
    Mutagenesis 24:351-7. 2009
    ....
  86. pmc DNA repair capacity as a possible biomarker of breast cancer risk in female BRCA1 mutation carriers
    J Kotsopoulos
    Centre for Research in Women s Health, Women s College Hospital, 790 Bay Street, Room 750, 7th Floor, Toronto, Ontario, Canada
    Br J Cancer 96:118-25. 2007
    ..These data suggest that these assays are not likely to be useful in the identification of women at a high risk for breast cancer...
  87. ncbi Micronucleus frequency in buccal mucosa cells of mobile phone users
    Henning Hintzsche
    Department of Toxicology, University of Wuerzburg, Wuerzburg, Germany
    Toxicol Lett 193:124-30. 2010
    ..A second scorer counted another 1000 cells, resulting in 2000 analyzed cells per individual. Mobile phone use did not lead to a significantly increased frequency of micronuclei...
  88. ncbi Chromosome aberrations study of pupils in high radon level elementary school
    M Bilban
    Institute of Occupational Safety, Ljubljana, Slovenia
    Health Phys 80:157-63. 2001
    ....
  89. pmc Mitochondrial dysfunction resulting from loss of cytochrome c impairs radiation-induced bystander effect
    G Yang
    State Key Laboratory of Nuclear Physics and Technology, Peking University, Beijing 100871, People s Republic of China
    Br J Cancer 100:1912-6. 2009
    ....
  90. ncbi Relative sensitivity of fish and mammalian cells to the antibiotic, trimethoprim: cytotoxic and genotoxic responses as determined by neutral red retention, Comet and micronucleus assays
    Elena Papis
    School of Biomedical and Biological Sciences, University of Plymouth, Plymouth, PL4 8AA, UK
    Ecotoxicology 20:208-17. 2011
    ....
  91. ncbi Genetic damage in chronic renal failure patients is associated with the glomerular filtration rate index
    Silvia Berenice Sandoval
    Grup de Mutagenesi, Departament de Genetica i de Microbiologia, Edifici Cn, Universitat Autonoma de Barcelona, 08193 Bellaterra, Cerdanyola del Valles, Spain
    Mutagenesis 25:603-8. 2010
    ..The fact that an increased level of MN is already observed in patients' Stage 2 seems to indicate a genetic predisposition on these patients. Nevertheless, part of the observed damage can be attributed to the uraemic state itself...
  92. ncbi Human lymphocytes micronucleus assay in Europe. An international survey
    J Surralles
    Department of Genetics, Radiation Genetics and Chemical Mutagenesis, Sylvius Laboratories, Leiden University, The Netherlands
    Mutat Res 392:165-74. 1997
    ....
  93. ncbi Transcriptomic network analysis of micronuclei-related genes: a case study
    D M van Leeuwen
    Department of Health Risk Analysis and Toxicology, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands
    Mutagenesis 26:27-32. 2011
    ..In conclusion, we have shown that network analysis of transcriptomics data in relation to the formation of MN is possible and provides a novel mechanistic hypothesis by indicating which genes are regulated and influence others...
  94. ncbi In vitro and in vivo genotoxicity tests on fullerene C60 nanoparticles
    Naohide Shinohara
    Research Institute of Science for Safety and Sustainability, AIST, 16 1, Onogawa, Tsukuba, Ibaraki 305 8569, Japan
    Toxicol Lett 191:289-96. 2009
    ..Therefore, we concluded that the stable and well-characterized C(60) nanoparticles did not have genotoxic ability in the bacterial reverse mutation assay, in vitro chromosome aberration assay, nor in vivo micronucleus assay...
  95. ncbi Relative sensitivity of fish and mammalian cells to sodium arsenate and arsenite as determined by alkaline single-cell gel electrophoresis and cytokinesis-block micronucleus assay
    Sheikh Raisuddin
    School of Biological Sciences, University of Plymouth, Plymouth, United Kingdom
    Environ Mol Mutagen 44:83-9. 2004
    ..Overall, the study demonstrated that the fish cells are more sensitive than the mammalian cells at environmentally realistic concentrations of both arsenicals, with arsenite being more toxic...
  96. ncbi Cytogenetic effects in children and mothers exposed to air pollution assessed by the frequency of micronuclei and fluorescence in situ hybridization (FISH): a family pilot study in the Czech Republic
    Marie Pedersen
    Institute of Public Health, Department of Environmental and Occupational Health, University of Copenhagen, DK 1014 K Copenhagen, Denmark
    Mutat Res 608:112-20. 2006
    ....
  97. ncbi High-content micronucleus assay in genotoxicity profiling: initial-stage development and some applications in the investigative/lead-finding studies in drug discovery
    Madhu S Mondal
    Preclinical Safety Profiling, CPC, Novartis Institutes of Biomedical Research, Inc, Cambridge, Massachusetts 02139, USA
    Toxicol Sci 118:71-85. 2010
    ..g., slide-based MN test in TK6 lymphoblastoid cells) that is used for full characterization of lead candidates...
  98. ncbi Evaluation of the genotoxicity of 10 selected dietary/environmental compounds with the in vitro micronucleus cytokinesis-block assay in an interlaboratory comparison
    Jelena Katic
    Institute for Medical Research and Occupational Health, Zagreb, Croatia
    Food Chem Toxicol 48:2612-23. 2010
    ....
  99. ncbi Mutagen sensitivity of peripheral blood from women carrying a BRCA1 or BRCA2 mutation
    Kristina Trenz
    Universitatsklinikum Ulm, Abteilung Humangenetik, D 89070 Ulm, Germany
    Mutat Res 500:89-96. 2002
    ....
  100. ncbi Biomonitoring of the genotoxic potential of aqueous extracts of soils and bottom ash resulting from municipal solid waste incineration, using the comet and micronucleus tests on amphibian (Xenopus laevis) larvae and bacterial assays (Mutatox and Ames test
    F Mouchet
    Laboratoire d Ecologie des Hydrosystèmes LEH, FRE CNRS UPS 2630, Centre Universitaire de Formation et de Recherche Jean François Champollion, Campus d Albi, Place de Verdun, 81012 Albi Cedex 9, France
    Sci Total Environ 355:232-46. 2006
    ..The results confirm the ecotoxicological relevance of the amphibian model and underscore the importance of bioassays, as a complement to physico-chemical data, for risk evaluation...
  101. pmc In vitro micronucleus assay scored by flow cytometry provides a comprehensive evaluation of cytogenetic damage and cytotoxicity
    Steven M Bryce
    Litron Laboratories, 200 Canal View Blvd, Rochester, NY, United States
    Mutat Res 630:78-91. 2007
    ..Collectively, these results indicate that a comprehensive assessment of genotoxicity and other test article-induced toxicities can be acquired simultaneously using a simple two-color flow cytometry-based technique...

Research Grants21

  1. Measuring Cytogenetic Damage in Human Blood
    Stephen Dertinger; Fiscal Year: 2003
    ..abstract_text> ..
  2. Automation of the vitro Micronucleus Assay
    Stephen Dertinger; Fiscal Year: 2004
    ..abstract_text> ..
  3. In vivo mutation assay based on pig-a locus
    Stephen Dertinger; Fiscal Year: 2004
    ....
  4. Rapid Screen for Genotoxicants, Chemoprotectors, and Radioprotectors
    Stephen Dertinger; Fiscal Year: 2008
    ..In addition, this assay can be used to investigate agents designed to ameliorate the effects of radiation exposure, e.g. biological response modifiers. [unreadable] [unreadable] [unreadable] [unreadable]..
  5. High Throughput Radiation Biodosimetry
    Stephen Dertinger; Fiscal Year: 2007
    ..We propose to develop such a radiation biodosimetry assay based on the extremely high analysis rates that are possible with flow cytometry instrumentation. [unreadable] [unreadable] [unreadable]..
  6. Versatile Mutation Assay Platform
    Stephen Dertinger; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  7. Molecular Biomarkers as Predictors of Hodgkin's Disease
    Randa El Zein; Fiscal Year: 2007
    ..The high risk population can be targeted for intensive preventive and early detection strategies. ..
  8. PON1 and Developmental Sensitivity to OP Pesticides
    Nina T Holland; Fiscal Year: 2010
    ..These data will support planning for the National Children's Study, identify subpopulations susceptible to chemical warfare agents, and inform policy decisions for implementation of the Food Quality Protection Act. ..
  9. Flow Cytometric Method to Analyze Micronuclei
    Dorothea Torous; Fiscal Year: 2002
    ..Similar studies are planned for analysis kits to measure MN in mouse and rat bone marrow, rat peripheral blood and also human peripheral blood. Enormous commercial opportunity exists from the sale of these kits. ..
  10. Assessing toxicity with an ex vivo erythropoiesis system
    Dorothea Torous; Fiscal Year: 2003
    ..2. MEASURE the frequency of micronuclei in ex vivo derived reticulocytes. 3. DETERMINE the responsiveness of the system to known clastogens and a model aneugen. ..
  11. Radioprotective Potential of Ginseng
    Tung Kwang Lee; Fiscal Year: 2006
    ..Accomplishing these aims will provide an essential prerequisite to the development of NAGE as an effective radioprotector. ..
  12. Cancer Risks Attributable To Radiation from Pediatric CT
    David Brenner; Fiscal Year: 2006
    ..The target audiences will be radiologists, pediatricians, family physicians, and the CT industry. We will use telephone interviews supplemented with survey questions, to aid in web content decisions. ..
  13. High Stability Accelerator for Sub-Cellular Microbeam
    David Brenner; Fiscal Year: 2003
    ..We have considerably more demand for microbeam time than we can cope with, primarily because of limited physicist manpower. ..
  14. Radiosensitization by the Cellular Stress Response
    Joseph Roti Roti; Fiscal Year: 2008
    ..This project will then modify indoles to reduce toxicity while enhancing the radiosensitized effects. ..
  15. VALIDATION OF A HUMAN CD34+ STEM CELL TOXICITY BIOASSAY
    Leslie Recio; Fiscal Year: 2008
    ..Therefore, these cells present a unique model system to understand and assess the effects of environmental agents and new drug candidates to predict or anticipate toxicity in humans. [unreadable] [unreadable] [unreadable]..
  16. TRIOXANES FOR CHEMOTHERAPY OF MALARIA AND CANCER
    Gary Posner; Fiscal Year: 2005
    ....
  17. Chemoprevention/Therapy Using Non-Calcemic Vitamin D
    Gary Posner; Fiscal Year: 2006
    ..Collectively, these studies will provide important structure- activity insights into the cancer chemoprotective and chemotherapeutic actions and molecular biology of vitamin D3 analogs. ..
  18. PESTICIDES--HEALTH FERTILITY AND REPRODUCTIVE RISK
    VINCENT GARRY; Fiscal Year: 2002
    ..Preliminary laboratory data are consistent and suggest that endocrine disruption and chromosomal effects in the male appliers may be important factors in the apparent decrease in fertility. ..
  19. RADIOLOGICAL RESEARCH ACCELERATOR FACILITY (RARAF)
    David Brenner; Fiscal Year: 2002
    ..abstract_text> ..
  20. NUCLEAR PROTEIN CONTENT AND HEAT INDUCED CELL KILLING
    Joseph Roti Roti; Fiscal Year: 2004
    ..1 degree C hyperthermia in a manner analogous to that at 43 degree C - 45 degree C. ..