- R/qtl: QTL mapping in experimental crosses
Karl W Broman
Department of Biostatistics, Johns Hopkins University, 615 N Wolfe St, Baltimore, MD 21205, USA
Bioinformatics 19:889-90. 2003
- The Collaborative Cross, a community resource for the genetic analysis of complex traits
Gary A Churchill
The Jackson Laboratory, 600 Main Street Bar Harbor, Maine 04609, USA
Nat Genet 36:1133-7. 2004
..The Collaborative Cross will provide a common reference panel specifically designed for the integrative analysis of complex systems and will change the way we approach human health and disease...
- Permutation tests for multiple loci affecting a quantitative character
R W Doerge
Biometrics Unit, Cornell University, Ithaca, New York 14853, USA
Genetics 142:285-94. 1996
..The search space for minor QTL is unrestricted, and RET-based tests may be more powerful than the CET-based test when the structural model is approximately true...
- Map Manager QTX, cross-platform software for genetic mapping
K F Manly
Cellular and Molecular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Mamm Genome 12:930-2. 2001
..which allow it to be compiled for multiple computer platforms. It currently is distributed for Microsoft Windows and Mac OS and is available at http://mapmgr.roswellpark.org/mmQTX.html...
- The pseudo-response regulator Ppd-H1 provides adaptation to photoperiod in barley
Crop Genetics Department, John Innes Centre, Norwich Research Park, Colney, Norwich NR4 7UH, UK
Science 310:1031-4. 2005
- Genetic dissection of transcriptional regulation in budding yeast
Rachel B Brem
Fred Hutchinson Cancer Research Center FHCRC, 1100 Fairview Avenue North, D4 100, Seattle, WA 98109, USA and Howard Hughes Medical Institute
Science 296:752-5. 2002
..We found eight such trans-acting loci, each affecting the expression of a group of 7 to 94 genes of related function...
- A single gene causes both male sterility and segregation distortion in Drosophila hybrids
Department of Biology, University of Rochester, Rochester, NY 14627 0211, USA
Science 323:376-9. 2009
..This segregation distorter gene is essential for hybrid sterility, a strong reproductive barrier between these young taxa. Our results suggest that genetic conflict may be an important evolutionary force in speciation...
- The genetic architecture of divergence between threespine stickleback species
C L Peichel
Department of Developmental Biology and Howard Hughes Medical Institute, Stanford University, Stanford, California 94305-5329, USA
Nature 414:901-5. 2001
..Further study of these regions will help to define the number and type of genetic changes that underlie morphological diversification during vertebrate evolution...
- The recombinational anatomy of a mouse chromosome
Center for Genome Dynamics, The Jackson Laboratory, Bar Harbor, Maine, United States of America
PLoS Genet 4:e1000119. 2008
..It appears that the regulation of mammalian recombination is a complex, dynamic process involving multiple factors reflecting species, sex, individual variation within species, and the properties of individual hotspots...
- Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
Science 286:1735-8. 1999
..Thus, Bim is required for hematopoietic homeostasis and as a barrier to autoimmunity. Moreover, particular death stimuli appear to activate apoptosis through distinct BH3-only proteins...
- Deletion of beta 1 integrins in mice results in inner cell mass failure and peri-implantation lethality
L E Stephens
Department of Stomatology, University of California, San Francisco 94143 0512, USA
Genes Dev 9:1883-95. 1995
- A statistical framework for quantitative trait mapping
The Jackson Laboratory, Bar Harbor, Maine 04609, USA
Genetics 159:371-87. 2001
..A software tool implementing this procedure is available. We demonstrate our approach to QTL analysis using data from a mouse backcross population that is segregating multiple interacting QTL associated with salt-induced hypertension...
- Multiple interval mapping for quantitative trait loci
C H Kao
Institute of Statistical Science, Academia Sinica, Taipei 11529, Taiwan, Republic of China
Genetics 152:1203-16. 1999
..The MIM FORTRAN program is available on the worldwide web (http://www.stat.sinica.edu.tw/chkao/)...
- Generation of a prostate epithelial cell-specific Cre transgenic mouse model for tissue-specific gene ablation
Department of Pathology, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90089, USA
Mech Dev 101:61-9. 2001
..The PB-Cre4 mice will be a useful resource for genetic-based studies on prostate development and prostatic disease...
- Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems
Departments of Pathology and Medicine, College of Physicians and Surgeons, Columbia University, 630 W 168th Street, P and S 14 453, New York, NY 10032, USA
Proc Natl Acad Sci U S A 96:1563-8. 1999
..Taken together, these data suggest that PTEN is a regulator of apoptosis and proliferation that behaves as a "landscaper" tumor suppressor in the gut and a "gatekeeper" tumor suppressor in other organs...
- The master sex-determination locus in threespine sticklebacks is on a nascent Y chromosome
Catherine L Peichel
Department of Developmental Biology and Howard Hughes Medical Institute, Stanford University School of Medicine, Palo Alto, CA 94305, USA
Curr Biol 14:1416-24. 2004
..Here, we investigate the genetic and chromosomal mechanisms that underlie sex determination in the threespine stickleback (Gasterosteus aculeatus)...
- Parent-of-origin effects on seed development in Arabidopsis thaliana
R J Scott
Department of Biology, University of Leicester, University Road, Leicester LE1 7RH, UK
Development 125:3329-41. 1998
..One explanation of our observations is that seeds with maternal or paternal excess contain different doses of maternally or paternally expressed imprinted loci affecting endosperm development...
- Using progenitor strain information to identify quantitative trait nucleotides in outbred mice
Wellcome Trust Centre for Human Genetics, Oxford University, UK
Genetics 171:673-81. 2005
- Genetics of gene expression surveyed in maize, mouse and man
Eric E Schadt
Rosetta Inpharmatics, LLC, 12040 115th Avenue N E, Kirkland, Washington 98034, USA
Nature 422:297-302. 2003
..We identify a gene expression pattern strongly associated with obesity in a murine cross, and observe two distinct obesity subtypes. Furthermore, we find that these obesity subtypes are under the control of different loci...
- The hidden side of invasions: massive introgression by local genes
Computational and Molecular Population Genetics Laboratory, Institute of Zoology, University of Bern, Baltzerstrasse 6, 3012 Berne, Switzerland
Evolution 62:1908-20. 2008
..Our results imply that speciation genes can be identified by comparing genomes of interfertile native and invading species pairs...
- Diversity Arrays Technology (DArT) for whole-genome profiling of barley
Center for the Application of Molecular Biology to International Agriculture, G P O Box 3200, Canberra, ACT 2601, Australia
Proc Natl Acad Sci U S A 101:9915-20. 2004
..These results highlight the potential of DArT as a generic technique for genome profiling in the context of molecular breeding and genomics...
- Integrating genetic and network analysis to characterize genes related to mouse weight
Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, California, USA
PLoS Genet 2:e130. 2006
..Our approach results in the identification of genetic targets that influence gene modules (pathways) that are related to the clinical phenotypes of interest...
- Powdery mildew resistance and Lr34/Yr18 genes for durable resistance to leaf and stripe rust cosegregate at a locus on the short arm of chromosome 7D of wheat
CSIRO Plant Industry, GPO Box 1600, Canberra, ACT 2601, Australia
Theor Appl Genet 111:731-5. 2005
..The Lr34/Yr18 phenotypes and associated powdery mildew resistance were mapped to a single locus flanked by microsatellite loci Xgwm1220 and Xgwm295 on chromosome 7DS...
- Comparative recombination rates in the rat, mouse, and human genomes
Michael I Jensen-Seaman
Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Genome Res 14:528-38. 2004
..This comparative approach provides additional insight into the causes and consequences of genomic heterogeneity in recombination...
- Simulating the collaborative cross: power of quantitative trait loci detection and mapping resolution in large sets of recombinant inbred strains of mice
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom
Genetics 172:1783-97. 2006
..However, even with a very large panel of RILs, mapping resolution may not be sufficient to identify single genes unambiguously. Our results are generally applicable to the design of RILs in other species...
- Poor performance of bootstrap confidence intervals for the location of a quantitative trait locus
Department of Biostatistics, Johns Hopkins University, Baltimore, Maryland 21205 2179, USA
Genetics 174:481-9. 2006
..Likelihood support intervals and approximate Bayes credible intervals, on the other hand, are shown to behave appropriately...
- Model for mapping imprinted quantitative trait loci in an inbred F2 design
Department of Statistics, University of Florida, Gainesville, FL 32611, USA
Genomics 87:543-51. 2006
..Our approach provides a standard procedure for testing the statistical significance of iQTL involved in the genetic control of complex traits...
- Two meiotic crossover classes cohabit in Arabidopsis: one is dependent on MER3,whereas the other one is not
Station de Genetique et d Amelioration des plantes, Institut National de la Recherche Agronomique, Versailles, France
Curr Biol 15:692-701. 2005
..The situation in mammals and plants remains unclear. Mer3 is one of the genes shown to be required for the formation of interference-sensitive crossovers in Saccharomyces cerevisiae...
- The Collaborative Cross at Oak Ridge National Laboratory: developing a powerful resource for systems genetics
Elissa J Chesler
Systems Genetics Group, Biosciences Division, Oak Ridge National Laboratory, Bldg 1059 MS 6420, P O Box 2008, Oak Ridge, TN 37831 6420, USA
Mamm Genome 19:382-9. 2008
..Herein we present a progress report of the Collaborative Cross breeding program at ORNL and a description of the kinds of investigations that this resource will support...
- MCQTL: multi-allelic QTL mapping in multi-cross design
Marie Françoise Jourjon
INRA, Unité de Biométrie et d Intelligence Artificielle B P 27, 31326 Castanet Tolosan, France
Bioinformatics 21:128-30. 2005
..Marker cofactor selections by forward or backward stepwise methods are implemented as well as computation of threshold test value by permutation...
- Asymmetric postmating isolation: Darwin's corollary to Haldane's rule
Section of Evolution and Ecology, University of California, Davis, California 95616, USA
Genetics 176:1059-88. 2007
..Comparing our predictions to data from diverse taxa indicates that unidirectional DMIs, specifically involving sex chromosomes, cytoplasmic elements, and maternal effects, are likely to play an important role in postmating isolation...
- Strategies for mapping and cloning quantitative trait genes in rodents
Wellcome Trust Centre for Human Genetics, Oxford University, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
Nat Rev Genet 6:271-86. 2005
..We review the potential of these strategies to identify genes that underlie QTLs in rodents...
- Segregation of QTL for production traits in commercial meat-type chickens
D J De Koning
Roslin Institute, Roslin, Midlothian EH25 9PS, UK
Genet Res 83:211-20. 2004
..Future fine-mapping efforts could elucidate whether ancestral mutations are still segregating as a result of pleiotropic effects on fitness traits or whether this variation is due to new mutations...
- High potential of a transposon mPing as a marker system in japonica x japonica cross in rice
Plant Breeding Laboratory, Division of Agronomy and Horticulture Science, Graduate School of Agriculture, Kyoto University, Kyoto, Japan
DNA Res 16:131-40. 2009
..Moreover, we could easily map two novel loci involved in the culm length on the short arms of chromosomes 3 and 10...
- Genetics of hybrid incompatibility between Lycopersicon esculentum and L. hirsutum
Leonie C Moyle
Center for Population Biology, University of California, Davis, California 95616, USA
Genetics 169:355-73. 2005
..The observed differences between Lycopersicon and Drosophila might be due to differences in sex determination system, reproductive and mating biology, and/or the prevalence of sexual interactions such as sexual selection...
- Mapping quantitative trait loci for yield, yield components and morphological traits in an advanced backcross population between Oryza rufipogon and the Oryza sativa cultivar Jefferson
M J Thomson
Department of Plant Breeding, 240 Emerson Hall, Cornell University, Ithaca, NY 14853 1901, USA
Theor Appl Genet 107:479-93. 2003
- Identification and dissection of a complex DNA repair sensitivity phenotype in Baker's yeast
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America
PLoS Genet 4:e1000123. 2008
..It also provides tools for understanding the effect of genetic background on sensitivity to genotoxic agents...
- Genome-wide, large-scale production of mutant mice by ENU mutagenesis
M H Hrabe de Angelis
Institute of Experimental Genetics, GSF Research Center for Environment and Health, Neuherberg, Germany
Nat Genet 25:444-7. 2000
..Our mutant lines are freely accessible to non-commercial users (for information, see http://www.gsf.de/ieg/groups/enu-mouse.html)...
- Epigenetic inheritance at the agouti locus in the mouse
H D Morgan
Department of Biochemistry, University of Sydney, NSW, 2006, Australia
Nat Genet 23:314-8. 1999
..Because retrotransposons are abundant in mammalian genomes, this type of inheritance may be common...
- Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice
Department of Internal Medicine, University of Tokyo Graduate School of Medicine, Tokyo 113 8655, Japan
J Biol Chem 277:19353-7. 2002
..In conclusion, SREBP-1 regulation of lipogenesis is highly involved in the development of fatty livers but does not seem to be a determinant of obesity in Lep(ob)/Lep(ob) mice...
- Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
Institut für Molekularbiologie I, Universitat Zurich, Switzerland
Nature 356:577-82. 1992
..It is now feasible to determine whether mice devoid of PrPC can propagate prions and are susceptible to scrapie pathogenesis...
- Cdkn2a, the cyclin-dependent kinase inhibitor encoding p16INK4a and p19ARF, is a candidate for the plasmacytoma susceptibility locus, Pctr1
Laboratory of Genetics, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4255, USA
Proc Natl Acad Sci U S A 95:2429-34. 1998
- Genome-wide epistatic interaction analysis reveals complex genetic determinants of circadian behavior in mice
Howard Hughes Medical Institute, Northwestern University, Evanston, Illinois 60208 3520, USA
Genome Res 11:959-80. 2001
- Extensive demethylation of repetitive elements during seed development underlies gene imprinting
Howard Hughes Medical Institute HHMI, Fred Hutchinson Cancer Research Center FHCRC, 1100 Fairview Avenue North, Seattle, WA 98109, USA
Science 324:1447-51. 2009
..These data suggest that imprinting in plants evolved from targeted methylation of transposable element insertions near genic regulatory elements followed by positive selection when the resulting expression change was advantageous...
- Extragenic bypass suppressors of mutations in the essential gene BLD2 promote assembly of basal bodies with abnormal microtubules in Chlamydomonas reinhardtii
A M Preble
Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309-0347, USA
Genetics 157:163-81. 2001
..It is likely that BLD2 is an essential gene that is needed for basal body assembly and function...
- A Drosophila seminal fluid protein, Acp26Aa, stimulates egg laying in females for 1 day after mating
L A Herndon
Section of Genetics and Development, Cornell University, Ithaca, NY 14853 2703, USA
Proc Natl Acad Sci U S A 92:10114-8. 1995
..This effect is apparent only on the first day after mating. The null mutation has no other detectable physiological or behavioral effects on the male or the mated female...
- The Berkeley Drosophila Genome Project gene disruption project: Single P-element insertions mutating 25% of vital Drosophila genes
A C Spradling
Department of Embryology, Howard Hughes Medical Institute Research Laboratories, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
Genetics 153:135-77. 1999
..We predict that this approach can bring >85% of all Drosophila open reading frames under experimental control...
- ATM is required for telomere maintenance and chromosome stability during Drosophila development
Department of Biological Sciences, University of Alberta, Edmonton, Alberta, T6G 2E9, Canada
Curr Biol 14:1341-7. 2004
- The maternally inherited regulation of P elements in Drosophila melanogaster can be elicited by two P copies at cytological site 1A on the X chromosome
Mécanismes Moléculaires de la Spéciation, Universite Paris, France
Genetics 129:501-12. 1991
..By contrast, the partial regulation of delta 2-3(99B) somatic activity is chromosomally inherited. These results suggest that the regulatory P elements of the Lk-P(1A) line are inserted near a germline-specific enhancer...
- Discrimination of MHC-derived odors by untrained mice is consistent with divergence in peptide-binding region residues
Lara S Carroll
Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112 0841, USA
Proc Natl Acad Sci U S A 99:2187-92. 2002
- Morphological intergration between development compartments in the Drosophila wing
C P Klingenberg
Department of Zoology, Duke University, Durham, North Carolina 27708 0325, USA
Evolution 54:1273-85. 2000
..In contrast, much less of the shape variation in our sample can be attributed to the localized processes that establish the identity of particular wing veins...
- Further studies on using multiple-cross mapping (MCM) to map quantitative trait loci
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
Mamm Genome 17:1193-204. 2006
..We conclude that mapping in HS animals not only provides significantly greater QTL resolution, at least in some cases it provides significantly more information about the QTL haplotype structure...
- Genetic determinants of energy expenditure and insulin resistance in diet-induced obesity in mice
Research Division, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
Diabetes 53:3274-85. 2004
..e., the "thrifty gene," is a dominant-acting genetic determinant of diet-induced obesity in mice and can be linked to a locus on chromosome 14, including genes linked to adipose development and insulin sensitivity...
- Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies
Laboratory of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
Immunity 10:387-98. 1999
..e., chronic inflammatory arthritis and Crohn's-like inflammatory bowel disease, suggests that defective function of ARE may be etiopathogenic for the development of analogous human pathologies...
- Recombination can initiate and terminate at a large number of sites within the rosy locus of Drosophila melanogaster
S H Clark
Department of Molecular and Cell Biology, University of Connecticut, Storrs 06268
Genetics 118:261-6. 1988
..Contrary to expectation, significant recombination between these sites is seen...
- Maintenance of CpG methylation is essential for epigenetic inheritance during plant gametogenesis
Friedrich Miescher Institute for Biomedical Research, P O Box 2543, CH 4002 Basel, Switzerland
Nat Genet 34:65-9. 2003
- Coordinated genetic regulation of growth and lignin revealed by quantitative trait locus analysis of cDNA microarray data in an interspecific backcross of eucalyptus
Forest Biotechnology Group, North Carolina State University, Raleigh, NC 27695, USA
Plant Physiol 135:2368-78. 2004
..Sequence data for this article have been deposited with the EMBL/GenBank data libraries under accession numbers CB 967505 to CB 968059; CD 667988 to CD 670002; CD 670004; CD 670097; CD 670101 to CD 670112; and CD 670114 to CD 670137.)..
- Quantitative trait loci affecting ethanol sensitivity in BXD recombinant inbred mice
K E Browman
Portland Alcohol Research Center, Department of Veterans Affairs Medical Center and Department of Behavioral Neuroscience, Oregon Health Sciences University, 97201, USA
Alcohol Clin Exp Res 24:17-23. 2000
..Many QTL analyses have been performed in BXD recombinant inbred (RI) strains of mice derived from a cross of C57BL/6J (B6) and DBA/2J (D2) progenitor strains...
- Dominance, overdominance and epistasis condition the heterosis in two heterotic rice hybrids
Key Lab of the Ministry of Education for Plant Developmental Biology, College of Life Science, Wuhan University, Wuhan, China
Genetics 180:1725-42. 2008
..0 to 14.9%. These results suggest that the heterosis in these two hybrids is attributable to the orchestrated outcome of partial-to-complete dominance, overdominance, and epistasis...
- Classical genetic and quantitative trait loci analyses of heterosis in a maize hybrid between two elite inbred lines
Department of Agroenvironmental Sciences and Technologies, University of Bologna, 40127 Bologna, Italy
Genetics 176:625-44. 2007
..Some chromosome regions presented overlaps of overdominant QTL for SW, PH, NK, and GY, suggesting pleiotropic effects on overall plant vigor...
- Genetic changes in skin tumor progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7
Beatson Institute for Cancer Research, Bearsden, Glasgow, Scotland
Cell 61:407-17. 1990
..We conclude that gross chromosomal alterations that elevate the copy number of mutant H-ras and/or lead to loss of normal H-ras are a consistent feature of mouse skin tumor development...
- QTL mapping in new Arabidopsis thaliana advanced intercross-recombinant inbred lines
Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
PLoS ONE 4:e4318. 2009
..One strategy to increase the power of precisely localizing small effect QTL, is the use of an intercross approach before inbreeding to produce Advanced Intercross RILs (AI-RILs)...
- Reinforcement drives rapid allopatric speciation
Conrad J Hoskin
School of Integrative Biology, University of Queensland, St Lucia, Queensland 4072, Australia
Nature 437:1353-6. 2005
..Thus we show the potential for reinforcement to drive rapid allopatric speciation...
- Evolutionary history of Silene latifolia sex chromosomes revealed by genetic mapping of four genes
Dmitry A Filatov
School of Biosciences, University of Birmingham, Edgbaston, UK
Genetics 170:975-9. 2005
- Local spreading of MSL complexes from roX genes on the Drosophila X chromosome
Interdepartmental Program in Cell and Molecular Biology, Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Genes Dev 17:1334-9. 2003
..Thus, the protein components can carry out all essential functions of dosage compensation, but roX RNAs facilitate the correct targeting of MSL complexes, in part by nucleation of spreading from their sites of synthesis...
- Insulin regulation of heart function in aging fruit flies
Robert J Wessells
The Burnham Institute, Center for Neuroscience and Aging, 10901 Torrey Pines Road, La Jolla, California 92037, USA
Nat Genet 36:1275-81. 2004
..The aging fly heart is a model for studying the genetics of age-sensitive organ-specific pathology...
- Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation
Mariana de Napoles
Developmental Epigenetics Group, MRC Clinical Sciences Centre, ICFM, Hammersmith Hospital, DuCane Road, London W12 ONN, United Kingdom
Dev Cell 7:663-76. 2004
..These observations link H2A ubiquitylation, X inactivation, and PRC1 PcG function, suggesting an unanticipated and novel mechanism for chromatin-mediated heritable gene silencing...
- Cytoplasmic male sterility: a window to the world of plant mitochondrial-nuclear interactions
Christine D Chase
Horticultural Sciences Department, University of Florida Institute of Food and Agricultural Sciences, Gainesville, FL 32611 0690, USA
Trends Genet 23:81-90. 2007
..The molecular cloning of nuclear genes that restore fertility (i.e. restorer-of-fertility genes) has identified genes encoding pentatricopeptide-repeat proteins as key regulators of plant mitochondrial gene expression...
- On the detection of imprinted quantitative trait loci in experimental crosses of outbred species
Dirk Jan de Koning
Animal Breeding and Genetics Group, Wageningen Institute of Animal Sciences, Wageningen University, 6700 AH Wageningen, The Netherlands
Genetics 161:931-8. 2002
..When QTL were segregating in the founder lines, spurious detection of imprinting became more prominent under both tests, especially for designs with a small number of F1 sires...
- Genetic linkage of ecological specialization and reproductive isolation in pea aphids
D J Hawthorne
Department of Entomology, University of Maryland, College Park 20742, USA
Nature 412:904-7. 2001
..This type of genetic architecture may be common in taxa that have speciated under divergent natural selection...
- Fine mapping of a yield-enhancing QTL cluster associated with transgressive variation in an Oryza sativa x O. rufipogon cross
College of Agriculture and Life Sciences, Chungnam National University, Daejeon, 305 764, South Korea
Theor Appl Genet 116:613-22. 2008
..4 kb interval suggests the possibility that a single, pleiotropic gene acting as a major regulator of plant development may control this suite of agronomically important plant phenotypes...
- Fine mapping of a seizure susceptibility locus on mouse Chromosome 1: nomination of Kcnj10 as a causative gene
Thomas N Ferraro
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Mamm Genome 15:239-51. 2004
..The critical interval contains several candidate genes, one of which, Kcnj10, exhibits a potentially important polymorphism with regard to fundamental aspects of seizure susceptibility...
- Distinct genetic loci control development of benign and malignant skin tumours in mice
CRC Beatson Laboratories, Department of Medical Oncology, University of Glasgow, UK
Nat Genet 10:424-9. 1995
..On the other hand, probably a single locus on chromosome 5 affects both early and late stages of malignancy. The results indicate that benign and malignant tumours are largely under independent genetic control...
- Development, utilization of introgression lines using a synthetic wheat as donor
Key Lab of Crop Germplasm and Biotechnology, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, 100081, Beijing, China
Theor Appl Genet 112:1360-73. 2006
..In total, 38, 33, and 28 putative QTLs were detected for seven of the nine traits in 2003, 2004, and 2005, respectively. Some of these agronomic important QTLs were detected in more than one season...
- Mapping quantitative trait loci (QTLs) for fatty acid composition in an interspecific cross of oil palm
Advanced Biotechnology and Breeding Centre, Biology Division, Malaysian Palm Oil Board MPOB, NO, 6, Persiaran Institusi, Selangor DE, Malaysia
BMC Plant Biol 9:114. 2009
..This will speed up the production of new and improved oil palm planting materials...
- A fine-scale genetic analysis of hybrid incompatibilities in Drosophila
Daven C Presgraves
Department of Biology, University of Rochester, Rochester, New York 14627, USA
Genetics 163:955-72. 2003
..Finally, I estimate that a total of approximately 191 hybrid-lethal incompatibilities separate D. melanogaster and D. simulans, indicating extensive functional divergence between these species' genomes...
- Cancer susceptibility in the mouse: genetics, biology and implications for human cancer
Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Nat Rev Genet 4:721-34. 2003
..In future, this unique approach is likely to provide important insights into the pathways of tumour development and might ultimately lead to more effective individually targeted cancer-prevention strategies...
- A composite linkage map from two crosses for the species complex Picea mariana x Picea rubens and analysis of synteny with other Pinaceae
Chaire de recherche du Canada en génomique forestière et environnementale, Centre de recherche en biologie forestière, Pavillon Charles Eugène Marchand, Universite Laval, Sainte Foy, QC, G1K 7P4, Canada
Theor Appl Genet 111:1466-88. 2005
..Implications for the evolution of the Pinaceae genome are discussed...
- Diversifying selection in plant breeding
Department of Plant Breeding and Genetics at Cornell University, Ithaca, New York, USA
PLoS Biol 2:e347. 2004
- Genetic mapping of quantitative trait loci for growth and fatness in pigs
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala
Science 263:1771-4. 1994
..The genetic mapping of a major locus for fat deposition in the pig could have implications for understanding human obesity...
- Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice
D J Rawlings
Department of Microbiology and Molecular Genetics, University of California, Los Angeles 90024
Science 261:358-61. 1993
..A single conserved residue within the amino terminal unique region of Btk was mutated in XID mice. This change in xid probably interferes with normal B cell signaling mediated by Btk protein interactions...
- Success and virulence in Toxoplasma as the result of sexual recombination between two distinct ancestries
M E Grigg
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305-5124, USA
Science 294:161-5. 2001
..Thus, sexual recombination, by combining polymorphisms in two distinct and competing clonal lines, can be a powerful force driving the natural evolution of virulence in this highly successful pathogen...
- Iron accumulation with age, oxidative stress and functional decline
Department of Aging and Geriatrics, Division of Biology of Aging, Genomics and Biomarkers Core of the Institute on Aging, University of Florida, Gainesville, Florida, United States of America
PLoS ONE 3:e2865. 2008
..These findings strongly suggest that the age-related iron accumulation in muscle contributes to increased oxidative damage and sarcopenia, and that CR effectively attenuates these negative effects...
- Loci predisposing to autoimmunity in MRL-Fas lpr and C57BL/6-Faslpr mice
Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
J Clin Invest 101:696-702. 1998
..The identification of loci with highly significant linkage to disease manifestations in Faslpr strains will make it possible to map and clone new genetic defects contributing to autoimmunity...
- Single QTL effects, epistasis, and pleiotropy account for two-thirds of the phenotypic F(2) variance of growth and obesity in DU6i x DBA/2 mice
G A Brockmann
Research Institute for the Biology of Farm Animals, 18196 Dummerstorf, Germany
Genome Res 10:1941-57. 2000
..The quantitative trait loci described in this paper have been submitted to the Mouse Genome Database.]..
- The genetic architecture of fitness in a seed beetle: assessing the potential for indirect genetic benefits of female choice
Animal Ecology Department of Ecology and Evolution, Evolutionary Biology Centre, University of Uppsala, Uppsala SE 753 32, Sweden
BMC Evol Biol 8:295. 2008
..From reciprocal crosses of inbred lines, we assayed egg production, egg-to-adult survival, and lifetime offspring production of the outbred F1 daughters (F1 productivity)...
- Genetics and the fitness of hybrids
J M Burke
Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
Annu Rev Genet 35:31-52. 2001
..In contrast, increased hybrid fitness can be most readily explained through the segregation of additive genetic factors, with epistasis playing a more limited role...
- A genome-wide survey of hybrid incompatibility factors by the introgression of marked segments of Drosophila mauritiana chromosomes into Drosophila simulans
J R True
Department of Zoology, Duke University, Durham, North Carolina 27708, USA
Genetics 142:819-37. 1996
- Identification of nitric oxide synthase as a protective locus against tuberculosis
J D MacMicking
Beatrice and Samuel A Seaver Laboratory, Department of Medicine, Cornell University Medical College, New York, NY 10021, USA
Proc Natl Acad Sci U S A 94:5243-8. 1997
..Progression of chronic tuberculosis in wild-type mice was accelerated by specifically inhibiting NOS2 via administration of N6-(1-iminoethyl)-L-lysine. Together these findings identify NOS2 as a critical host gene for tuberculostasis...
- Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand
Osaka Bioscience Institute, Japan
Cell 76:969-76. 1994
..These results indicate that lpr and gld are mutations in Fas and Fasl, respectively, and suggest important roles of the Fas system in development of T cells as well as cytotoxic T lymphocyte-mediated cytotoxicity...
- Tumor spectrum analysis in p53-mutant mice
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139
Curr Biol 4:1-7. 1994
..The construction of mouse strains carrying germline mutations of p53 facilitates analysis of the function of p53 in normal cells and tumorigenesis...
- Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice
C G Specht
Laboratory for Molecular Pharmacology, UCL, Gower Street, London WC1E 6BT, UK
BMC Neurosci 2:11. 2001
..Here we analyze potential compensatory mechanisms in alpha-synuclein null mutant mice. Furthermore, the findings reveal problems that may be associated with inbred mouse strains...
- An improved method for quantitative trait loci detection and identification of within-line segregation in F2 intercross designs
Linnaeus Centre for Bioinformatics, Uppsala University, 75124 Uppsala, Sweden
Genetics 178:2315-26. 2008
..Extensions of FIA and its applications on other intercross populations including backcrosses, advanced intercross lines, and heterogeneous stocks are also discussed...
- Effect of population size on the estimation of QTL: a test using resistance to barley stripe rust
M I Vales
Department of Crop and Soil Science, Oregon State University, Corvallis, OR 97331 3002, USA
Theor Appl Genet 111:1260-70. 2005
..The method of choice will depend on the relative costs of genotyping versus phenotyping...
- Quantitative trait locus mapping for meat quality traits in an Iberian x Landrace F2 pig population
Departamento de Mejora Genética Animal, INIA, Carretera La Coruña km 7, 28040 Madrid, Spain
J Anim Sci 80:2801-8. 2002
..In this work we identify genomic regions related with meat quality traits. Improvement by traditional selection methods is complicated, and finer mapping would be required for their application in introgression programs...
- Joint estimates of quantitative trait locus effect and frequency using synthetic recombinant populations of Drosophila melanogaster
Stuart J Macdonald
Department of Ecology and Evolutionary Biology, University of California, Irvine, California 92697, USA
Genetics 176:1261-81. 2007
..Models that seek to explain the maintenance of genetic variation make different predictions about the population frequency of QTL alleles. Thus, mapping QTL in eight-way recombinant populations can distinguish between these models...
- Weighted gene coexpression network analysis strategies applied to mouse weight
Tova F Fuller
Department of Human Genetics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA
Mamm Genome 18:463-72. 2007
..These examples provide evidence that integration of network properties may well help chart the path across the gene-trait chasm...
- Leaf tip necrosis, molecular markers and beta1-proteasome subunits associated with the slow rusting resistance genes Lr46/Yr29
G M Rosewarne
International Maize and Wheat Improvement Center CIMMYT, Apartado Postal 6 641, 06600, Km 45 Carretera Mexico Veracruz, 56130 El Batan, Texcoco, Mexico
Theor Appl Genet 112:500-8. 2006
..Coincidentally, members of a small gene family encoding beta-1 proteasome subunits located on group 1L and 7S chromosomes implicated in plant defense were linked to the Lr34/Yr18 and Lr46/Yr29 loci...
- Colorectal hyperplasia and inflammation in keratin 8-deficient FVB/N mice
La Jolla Cancer Research Foundation, California 92037
Genes Dev 8:2964-73. 1994
..More importantly, the increase in mK8-/- gut epithelial cell number, rather than cell disruption, contrasts with the known function of epidermal keratins in providing mechanical strength...
- Transgenic insulin (B:9-23) T-cell receptor mice develop autoimmune diabetes dependent upon RAG genotype, H-2g7 homozygosity, and insulin 2 gene knockout
Jean M Jasinski
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, P O Box 6511, MS B140, Aurora, CO 80045 6511, USA
Diabetes 55:1978-84. 2006
..scid mouse. The current study demonstrates that the BDC12-4.1 TCR is sufficient to cause diabetes at NOD backcross 1, bypassing polygenic inhibition of insulitis and diabetogenesis...
- Genetic control of resistance to experimental infection with virulent Mycobacterium tuberculosis
Department of Immunology and Infectious Diseases, Harvard School of Public Health, 667 Huntington Avenue, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 97:8560-5. 2000
..tuberculosis, indicating that other genes located outside of the sst1 locus are likely also to be important for controlling tuberculosis infection...