Genomes and Genes
Summary: Staining of bands, or chromosome segments, allowing the precise identification of individual chromosomes or parts of chromosomes. Applications include the determination of chromosome rearrangements in malformation syndromes and cancer, the chemistry of chromosome segments, chromosome changes during evolution, and, in conjunction with cell hybridization studies, chromosome mapping.
Publications247 found, 100 shown here
- Chromosome territories, nuclear architecture and gene regulation in mammalian cellsT Cremer
Institute of Anthropology and Human Genetics, Ludwig Maximilians University, Richard Wagner Strasse 10, D 80333 Munich, Germany
Nat Rev Genet 2:292-301. 2001..This view is consistent with a topological model for gene regulation...
- Recent radiation in West African Taterillus (Rodentia, Gerbillinae): the concerted role of chromosome and climatic changesG Dobigny
Museum national d histoire naturelle, Laboratoire Origine, Structure et Evolution de la Biodiversité, FRE CNRS 2695, 55, rue Buffon, Paris F75005, France
Heredity (Edinb) 95:358-68. 2005..This scenario would explain the current parapatric species distributions and their relationship to the West African hydrographic features...
- Explosive chromosome evolution and speciation in the gerbil genus Taterillus (Rodentia, Gerbillinae): a case of two new cryptic speciesG Dobigny
Laboratoire Mammifères et Oiseaux, Museum national d histoire naturelle, Paris, France
Cytogenet Genome Res 96:117-24. 2002..Possible factors responsible for the rapid karyotypic evolution and speciation in this West African gerbil complex are discussed...
- Distribution of (TTAGGG)n telomeric sequences in karyotypes of the Xenopus species complexI Nanda
Department of Human Genetics, University of Wurzburg, Wurzburg, Germany
Cytogenet Genome Res 122:396-400. 2008..clivii do not necessarily represent the relic of ancestral telomeres resulting from the fusion of chromosomes, but their occurrence is due to the fact that (TTAGGG)(n) repeat arrays may be a constituent of highly repetitive DNA...
- Comprehensive genetic characterization of CLL: a study on 506 cases analysed with chromosome banding analysis, interphase FISH, IgV(H) status and immunophenotypingC Haferlach
MLL Munich Leukemia Laboratory, Munich, Germany
Leukemia 21:2442-51. 2007In CLL data from chromosome banding analysis (CBA) have been scarce due to the low proliferative activity of CLL cells in vitro. We improved the cultivation technique using an immunostimulatory CpG-oligonucleotide DSP30 and IL-2...
- A phylogenetic analysis using multidirectional chromosome painting of three species (Uroderma magnirostrum, U. bilobatum and Artibeus obscurus) of subfamily Stenodermatinae (Chiroptera-Phyllostomidae)J C Pieczarka
Laboratorio de Citogenetica, ICB, UFPA, Belem, Brazil
Chromosome Res 21:383-92. 2013..The genome-wide comparative maps based on chromosome painting and chromosome banding reveal the chromosome forms that characterize each taxonomic level within the Phyllostomidae and show the ..
- Cytogenetic heteromorphisms: survey results and reporting practices of giemsa-band regions that we have pondered for yearsArthur R Brothman
Department of Pediatrics and Human Genetics, University of Utah School of Medicine, Salt Lake City, USA
Arch Pathol Lab Med 130:947-9. 2006..Cytogenetic heteromorphisms (normal variants) pose diagnostic dilemmas. Common Giemsa-band heteromorphisms are not described in the literature, although Giemsa-banding is the method most frequently used in cytogenetic laboratories...
- Chromosomal homologies among vampire bats revealed by chromosome painting (phyllostomidae, chiroptera)C G Sotero-Caio
Laboratório de Genética e Citogenética Animal, Departamento de Genética CCB, Universidade Federal de Pernambuco, Recife, Brazil
Cytogenet Genome Res 132:156-64. 2011..Karyotype comparisons allowed us to relate a number of conserved chromosomal segments among the 5 species, providing a broader database for understanding karyotype evolution in the family...
- Molecular cytogenetic characterization of the mouse cell line WMP2 by spectral karyotyping and multicolor banding applying murine probesConstanze Karst
Institute of Human Genetics and Anthropology, D 07743 Jena, Germany
Int J Mol Med 17:209-13. 2006..SKY revealed that the WMP2 cell line developed further four derivative chromosomes. After application of mcb five previously unrecognizable intrachromosomal rearrangements with 9 breakpoints were detected for the studied chromosomes...
- Chromosomal evolution in Rattini (Muridae, Rodentia)Daleen Badenhorst
Evolutionary Genomics Group, Botany and Zoology Department, University of Stellenbosch, Private Bag X1, 7604 Matieland, South Africa
Chromosome Res 19:709-27. 2011..species representative of the genera Maxomys, Leopoldamys, Niviventer, Berylmys, Bandicota and Rattus using chromosome banding, cross-species painting (Zoo-fluorescent in situ hybridization or FISH) and BAC-FISH mapping...
- FISH-microdissection (FISH-MD) analysis of complex chromosome rearrangementsJ Weimer
Oncology Laboratory, Gynecology and Obstetrics Clinic, Christian Albrechts University Kiel, Germany
Cytogenet Cell Genet 88:114-8. 2000..Rearranged chromosomes are first identified by multicolor-FISH, then the fluorophore-labeled derivative chromosomes are directly isolated by microdissection and reverse painted to identify the breakpoints...
- A comparative ZOO-FISH analysis in bats elucidates the phylogenetic relationships between Megachiroptera and five microchiropteran familiesM Volleth
Institut fur Humangenetik, Universitat Erlangen Nurnberg, Erlangen, Germany
Chromosome Res 10:477-97. 2002..Therefore, for karyological reasons, monophyly of Chiroptera is strongly supported...
- Karyotype relationships of six bat species (Chiroptera, Vespertilionidae) from China revealed by chromosome painting and G-banding comparisonL Ao
Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, PR China
Cytogenet Genome Res 115:145-53. 2006..The integration of our maps with the published maps has enabled us to deduce chromosomal homologies between human and these six vesper bats and provided new insight into the karyotype evolution of the family Vespertilionidae...
- A technique for preparing polytene chromosomes from Aedes aegypti (Diptera, Culicinae)Jairo Campos
Departamento de Zoologia, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, Brasil
Mem Inst Oswaldo Cruz 98:387-90. 2003..A simple technique should facilitate molecular cytogenetics used in the location of resistance and vector competence genes...
- Chromosome evolution and improved cytogenetic maps of the Y chromosome in cattle, zebu, river buffalo, sheep and goatG P Di Meo
National Research Council CNR, ISPAAM, Laboratory of Animal Cytogenetics and Gene Mapping, Via Argine 1085, 80147, Naples, Italy
Chromosome Res 13:349-55. 2005....
- Karyotypic evolution and phylogenetic relationships in the order Chiroptera as revealed by G-banding comparison and chromosome paintingLei Ao
Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, and Graduate School of the Chinese Academy of Sciences, Kunming, Yunnan, 650223, P R China
Chromosome Res 15:257-67. 2007..e. Pteropodiformes or Yinpterochiroptera) and thus improve our understanding on the karyotypic relationships and genome phylogeny of these bat species...
- Fragile sites in human and Macaca fascicularis chromosomes are breakpoints in chromosome evolutionA Ruiz-Herrera
Department de Biologia Cel lular i Fisiologia, Facultat de Medicina, Universitat Autonoma de Barcelona, Bellaterra, Spain
Chromosome Res 10:33-44. 2002..025) to the location of M. fascicularis fragile sites...
- PLAG1 gene alterations in salivary gland pleomorphic adenoma and carcinoma ex-pleomorphic adenoma: a combined study using chromosome banding, in situ hybridization and immunocytochemistryCarmo Martins
Centro de Investigacao de Patobiologia Molecular CIPM, Instituto Portugues de Oncologia de Francisco Gentil, Lisboa, Portugal
Mod Pathol 18:1048-55. 2005....
- Comparative molecular cytogenetic analysis of three Leuciscus species (Pisces, Cyprinidae) using chromosome banding and FISH with rDNAAlicja Boron
Department of Zoology, Faculty of Biology, University of Warmia and Mazury, M Oczapowskiego 5, Olsztyn, 10 718, Poland
Genetica 135:199-207. 2009..These NORs were CMA(3)-positive, GC-rich and C-positive heterochromatic sites in both species. Such chromosome banding features were also true for four NORs localizing on one of each SM and ST pair in L...
- Molecular basis for expression of common and rare fragile sitesEitan Zlotorynski
Department of Genetics, The Life Sciences Institute, The Hebrew University, Jerusalem, Israel 91904
Mol Cell Biol 23:7143-51. 2003....
- Reconstruction of the ancestral karyotype of eutherian mammalsF Richard
UMR 147 CNRS, Institut Curie, Section Recherche, 26 Rue d Ulm, 75248 Paris Cedex 05, France
Chromosome Res 11:605-18. 2003..Comparing chromosome banding with all ZOO-FISH data from literature or studied by us, this reconstruction can be proposed with only ..
- Comparative cytogenetics of bats (Chiroptera): the prevalence of Robertsonian translocations limits the power of chromosomal characters in resolving interfamily phylogenetic relationshipsXiuguang Mao
Kunming Institute of Zoology, Kunming, Yunnan, People s Republic of China
Chromosome Res 16:155-70. 2008..Both analyses clearly indicate the prevalence of homoplasic events that reduce the reliability of chromosomal characters for resolving interfamily relationships in bats...
- Chronic myeloid leukemia: a prospective comparison of interphase fluorescence in situ hybridization and chromosome banding analysis for the definition of complete cytogenetic response: a study of the GIMEMA CML WPNicoletta Testoni
Department of Hematology Oncology, L and A Seragnoli, University of Bologna and S Orsola Malpighi University Hospital, Bologna, Italy
Blood 114:4939-43. 2009In chronic myeloid leukemia, different methods are available to monitor the response to therapy: chromosome banding analysis (CBA), interphase fluorescence in situ hybridization (I-FISH), and real-time quantitative polymerase chain ..
- Comparative chromosome painting of four Siberian Vespertilionidae species with Aselliscus stoliczkanus and human probesA I Kulemzina
Molecular and Cellular Biology Department, Institute of Chemical Biology and Fundamental Medicine, SÐ RAS, Novosibirsk, Russia
Cytogenet Genome Res 134:200-5. 2011..auritus chromosome 16/17 using the HSA 16 probe explaining the different G-banding pattern in comparison to the homologous Myotis chromosome 16/17...
- Localization of the human CYP17 gene (cytochrome P450(17 alpha)) to 10q24.3 by fluorescence in situ hybridization and simultaneous chromosome bandingY S Fan
Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada
Genomics 14:1110-1. 1992..3. This precise assignment may facilitate the understanding of the molecular basis of 17 alpha-hydroxylase/17,20-lyase deficiency and the evolution of the CYP superfamily of genes...
- High-resolution chromosome painting reveals the first genetic signature for the chiropteran suborder Pteropodiformes (Mammalia: Chiroptera)Marianne Volleth
Department of Human Genetics, Otto von Guericke University, Leipziger Straße 44, 39120, Magdeburg, Germany
Chromosome Res 19:507-19. 2011..A subsequent survey across all major chiropteran families demonstrated that a paracentric inversion within this HSA 4 homologous segment could represent a synapomorphic character for the suborder Pteropodiformes...
- A girl with del(4)(q33) and occipital encephalocele: clinical description and molecular genetic characterization of a rare patientRoberto Quadrelli
Instituto de Genetica Medica, Hospital Italiano, Montevideo, Uruguay
Genet Test 11:4-10. 2007..In particular, the prominent occipital encephalocele has not been observed before in a terminal 4q deletion...
- Chromosome evolution in domestic bovids as revealed by chromosome banding and FISH-mapping techniquesL Iannuzzi
National Research Council CNR, ISPAAM, Laboratory of Animal Cytogenetics and Gene Mapping, Naples, Italy
Cytogenet Genome Res 126:49-62. 2009..Evolution of the Bovinae-Caprinae autosomes and gonosomes is discussed on the basis of the most recent advances in chromosome banding, linkage studies, FISH-mapping and molecular information.
- A natural triploid in Trichomycterus davisi (Siluriformes, Trichomycteridae): mitotic and meiotic characterization by chromosome banding and synaptonemal complex analysesLuciana Andreia Borin
Department of Cell Biology and Genetics, State University of Maringa, PR, Brazil
Genetica 115:253-8. 2002..Analysis of the synaptonemal complex (SC) by electronic microscopy shows that there is an incomplete pairing of the third set of chromosomes in the triploid individual...
- Comparison of genomes of eight species of sections Linum and Adenolinum from the genus Linum based on chromosome banding, molecular markers and RAPD analysisOlga V Muravenko
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia
Genetica 135:245-55. 2009..Linum and Adenolinum, respectively. The obtained results suggest that species with 2n = 16, 2n = 18 and 2n = 30 originated from a 16-chromosome ancestor...
- Spectral karyotyping and interphase FISH reveal abnormalities not detected by conventional G-banding. Implications for treatment stratification of childhood acute lymphoblastic leukaemia: detailed analysis of 70 casesAnn Nordgren
Department of Molecular Medicine, Karolinska Institutet, L8 02 Karolinska Hospital, SE 17176 Stockholm, Sweden
Eur J Haematol 68:31-41. 2002..Our results demonstrate the usefulness of SKY and interphase FISH for the identification of novel chromosome aberrations and cytogenetic abnormalities that provide prognostically important information in childhood ALL...
- Karyotype analysis of Lilium longiflorum and Lilium rubellum by chromosome banding and fluorescence in situ hybridisationK B Lim
Plant Research International, Business Unit Genetics and Breeding, Wageningen, The Netherlands
Genome 44:911-8. 2001..Based on these techniques, we could identify most of chromosomes of the L. longiflorum and L. rubellum karyotypes...
- Karyotype reorganisation in the subtilis group of birch mice (Rodentia, Dipodidae, Sicista): unexpected taxonomic diversity within a limited distributionY M Kovalskaya
Severtzov Institute of Ecology and Evolution, Russian Academy of Sciences, Moscow, Russia
Cytogenet Genome Res 132:271-88. 2011..We conducted a comprehensive, comparative chromosome banding analysis of 52 birch mice (21 localities) referable to the subtilis group and report the presence of 5 ..
- Comparative chromosome painting defines the karyotypic relationships among the domestic dog, Chinese raccoon dog and Japanese raccoon dogWenhui Nie
Key Laboratory of Cellular and Molecular Evolution, The Chinese Academy of Sciences, Kunming, Yunnan, Peoples Republic of China
Chromosome Res 11:735-40. 2003..The large difference in chromosome number between the Chinese and Japanese raccoon dogs suggests that they should be considered as two distinct species...
- Comparison of karyotypes of Acipenser oxyrinchus and A. sturio by chromosome banding and fluorescent in situ hybridizationFrancesco Fontana
Department of Biology, University of Ferrara, Via L Borsari 46, 44100 Ferrara, Italy
Genetica 132:281-6. 2008..oxyrinchus appear very similar from a cytogenetic point of view: these and molecular data repeatedly point out that A. sturio and A. oxyrinchus represent a sister clade in comparison to all other sturgeon species up to now studied...
- Localization by FISH of the 31 Texas nomenclature type I markers to both Q- and R-banded bovine chromosomesH Hayes
Institut National de la Recherche Agronomique, INRA CRJ, Jouy en Josas, France
Cytogenet Cell Genet 90:315-20. 2000..Taking into account that cattle, goat and sheep have very similar banded karyotypes, the data presented here will help to establish a definite and complete reference chromosome nomenclature for these species...
- Chromosome banding in Amphibia. XXX. Karyotype aberrations in cultured fibroblast cellsM Schmid
Department of Human Genetics, Biocenter, University of Wurzburg, Wurzburg, Germany
Cytogenet Genome Res 104:277-82. 2004..holbrooki and G. riobambae are tandem fusions between two or more chromosomes. These tandem fusions originating in vitro in long-termed cell cultures reflect the chromosome mutations which also took place during amphibian phylogenesis...
- Systematics and phylogeny of West African gerbils of the genus Gerbilliscus (Muridae: Gerbillinae) inferred from comparative G- and C-banding chromosomal analysesV Volobouev
Museum national d histoire naturelle, UMR 5202 Origine, Structure et Evolution de la Biodiversité, Paris, France
Cytogenet Genome Res 116:269-81. 2007....
- Karyotypic conservatism in the suborder Feliformia (Order Carnivora)P L Perelman
Institute of Cytology and Genetics, Novosibirsk, Russia
Cytogenet Genome Res 108:348-54. 2005....
- The ancestral carnivore karyotype (2n = 38) lives today in ringtailsWilliam G Nash
H and W Cytogenetic Services, Inc, Lovettsville, VA 20180, USA
J Hered 99:241-53. 2008..Banded chromosomes of the ACK are used to evaluate the consistency between recently determined molecular phylogenetic relationships and postulated cytogenetic dynamics in the same Carnivore species...
- Unusually extensive karyotype reorganization in four congeneric Gerbillus species (Muridae: Gerbillinae)V M Aniskin
Severtsov Institut of Ecology and Evolution, Russian Academy of Sciences, Moscow, Russia
Cytogenet Genome Res 112:131-40. 2006..Based on the chromosomal data obtained here, the systematic and geographic implications for these North African species are also discussed...
- Characterization of diploid, tetraploid and hexaploid Helianthus species by chromosome banding and FISH with 45S rDNA probeAndré L L Vanzela
Departamento de Biologia Geral, CCB, Universidade Estadual de Londrina, PR, Brazil
Genetica 114:105-11. 2002..Karyomorphological differences include variation in number, size and chromosome morphology, suggesting that rearrangements involving small heterochromatic and rDNA segments played a major role in karyotype evolution...
- Chromosome banding in three species of Hypsiboas (Hylidae, Hylinae), with special reference to a new case of B-chromosome in anuran frogs and to the reduction of the diploid number of 2n = 24 to 2n = 22 in the genusSimone Lilian Gruber
Departamento de Biologia, Instituto de Biociencias, Universidade Estadual Paulista UNESP, Av 24A, 1515, 13506 900 Rio Claro, SP, Brasil
Genetica 130:281-91. 2007....
- Consensus statement: chromosomal microarray is a first-tier clinical diagnostic test for individuals with developmental disabilities or congenital anomaliesDavid T Miller
Division of Genetics and Department of Laboratory Medicine, Children s Hospital Boston and Harvard Medical School, Boston, MA, USA
Am J Hum Genet 86:749-64. 2010..G-banded karyotype analysis should be reserved for patients with obvious chromosomal syndromes (e.g., Down syndrome), a family history of chromosomal rearrangement, or a history of multiple miscarriages...
- Evaluation of breast cancer polyclonality by combined chromosome banding and comparative genomic hybridization analysisM R Teixeira
Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
Neoplasia 3:204-14. 2001Cytogenetically unrelated clones have been detected by chromosome banding analysis in many breast carcinomas...
- Diversity in the origins of sex chromosomes in anurans inferred from comparative mapping of sexual differentiation genes for three species of the Raninae and XenopodinaeYoshinobu Uno
Laboratory of Animal Cytogenetics, Biosystems Science Course, Graduate School of Life Science, Hokkaido University, Sapporo, 060 0810, Japan
Chromosome Res 16:999-1011. 2008..laevis and R. rugosa. Cyp17, Cyp19, Dmrt1, Sox9, and WT1 were localized to autosomes in X. laevis and R. rugosa, suggesting that these five genes probably are not candidates for the sex-determining genes in the two anuran species...
- Protocols for cytogenetic studies of human embryonic stem cellsLorraine Faxon Meisner
Department of Population Health Sciences, University of Wisconsin, and Cell Line Genetics, LLC, 510 Charmany Drive, Suite 254, Madison, WI 53719, USA
Methods 45:133-41. 2008..The following discussion describes the cytogenetic methods used in our laboratory to study cultured hESCs, along with recommendations for integrating these methods into a plan for routine cell line quality control...
- The pattern of phylogenomic evolution of the CanidaeW G Nash
H and W Cytogenetic Services, Inc, Lovettsville, VA, USA
Cytogenet Cell Genet 95:210-24. 2001..The results indicate an ancestral episode of extensive centric fission leading to an ancestral canid genome organization that was subsequently reorganized by multiple chromosome fusion events in some but not all Canidae lineages...
- Multicolor chromosome banding (MCB) with YAC/BAC-based probes and region-specific microdissection DNA librariesT Liehr
Institute of Human Genetics and Anthropology, University of Jena, Jena, Germany
Cytogenet Genome Res 97:43-50. 2002Multicolor chromosome banding (MCB) allows the delineation of chromosomal regions with a resolution of a few megabasepairs, i.e., slightly below the size of most visible chromosome bands...
- Characterization of a wheat-Thinopyrum bessarabicum (T2JS-2BS.2BL) translocation lineZengjun Qi
National Key Laboratory of Crop Genetics and Germplasm Enhancement, Nanjing Agricultural University, Nanjing, 210095, China
Theor Appl Genet 121:589-97. 2010..In addition, four markers specific for the translocated segment were identified, which can be used for marker-aided screening...
- Chromosome evolution in three Brazilian Leptodactylus species (Anura, Leptodactylidae), with phylogenetic considerationsJoão Reinaldo Cruz Campos
Instituto de Biociencias, Univ Estadual Paulista, UNESP, Rio Claro, SP, Brasil
Hereditas 146:104-11. 2009..The data obtained here are in accordance with the proposed phylogeny to the genus, and the chromosomal analyses in these Leptodactylus showed that the karyotype evolution was based mainly in centric fusion and pericentric inversion...
- Molecular definition of high-resolution multicolor banding probes: first within the human DNA sequence anchored FISH banding probe setAnja Weise
Institute of Human Genetics and Anthropology, D 07740 Jena, Germany
J Histochem Cytochem 56:487-93. 2008..In summary, the unique possibilities of the MCB technique to characterize chromosomal breakpoints in one FISH experiment are now complemented by the feature of being anchored within the human DNA sequence at the BAC level...
- Cryptic duplication of 12q24.33 --> qter in a child with Angelman syndrome-simultaneous occurrence of two unrelated cytogenetic eventsM Sathanoori
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA, USA
Am J Med Genet A 143:985-94. 2007..We compare our case with the published cases, and discuss the implications of our findings and its relevance in addressing genetic counseling issues...
- Lissencephaly with der(17)t(17;20)(p13.3;p12.2)matMary Ann Thomas
F Clarke Fraser Clinical Genetics Unit, Division of Medical Genetics, Department of Pediatrics, Montreal Children s Hospital, Montreal, Quebec, Canada
Am J Med Genet A 124:292-5. 2004..This report may contribute to the delineation of a phenotype resulting from partial monosomy 17p and partial trisomy of 20p...
- Overrepresentation of small supernumerary marker chromosomes (sSMC) from chromosome 6 origin in cases with multiple sSMCThomas Liehr
Institut fur Humangenetik und Anthropologie, D 07740 Jena, Germany
Am J Med Genet A 140:46-51. 2006..1 approximately 12 --> q10::q10 --> p11.1 approximately 12::), respectively. Reversed array CGH using the DNA of the microdissected sSMC as probe confirmed the FISH results and enabled the rapid mapping of the breakpoints...
- Multitude multicolor chromosome banding (mMCB) - a comprehensive one-step multicolor FISH banding methodA Weise
Institute of Human Genetics and Anthropology, University of Jena, Jena, Germany
Cytogenet Genome Res 103:34-9. 2003Multicolor chromosome banding (MCB) using one single chromosome-specific MCB probe set per experiment was previously reported as powerful tool in molecular cytogenetics for the characterization of all kinds of human marker chromosomes...
- Microdissection-derived murine mcb probes from somatic cell hybridsVladimir Trifonov
Institut für Human Genetics and Anthropology, Postfach, D 07740 Jena, Germany
J Histochem Cytochem 53:791-2. 2005..During creation of the mcb-probes, the latter enabled an unambiguous identification of the, otherwise in GTG-banding, hardly distinguishable murine chromosomes...
- Cytogenetic aberrations in spontaneous endometrial adenocarcinomas in the BDII rat model as revealed by chromosome banding and comparative genome hybridizationAhmad Hamta
CMB Genetics, Lundberg Laboratory, Goteborg University, Box 462, SE 40530, Gothenburg, Sweden
Cancer Genet Cytogenet 159:123-8. 2005....
- Comparative chromosome banding analysis of three South American species of rice rats of the genus Oryzomys (Rodentia, Sigmodontinae)V T Volobouev
Laboratoire de Zoologie, Mammifères et Oiseaux, Museum national d histoire naturelle, Paris, France
Chromosome Res 8:295-304. 2000..In the light of available chromosomal and molecular data, the significance of intra- and interspecies karyotypic variability within Oryzomys and its relevance to systematics and phylogeny of the genus are discussed...
- Evolutionary conserved chromosomal segments in the human karyotype are bounded by unstable chromosome bandsA Ruiz-Herrera
Departament de Biologia Cellular, Fisiologia i Immunologia, Universitat Autonoma de Barcelona, Spain
Cytogenet Genome Res 108:161-74. 2005....
- Evolution of genome organizations of squirrels (Sciuridae) revealed by cross-species chromosome paintingTangliang Li
Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, Yunnan, People s Republic of China
Chromosome Res 12:317-35. 2004..The superorder Glires (orde Rodentia + order Lagomorpha) is firmly supported by two conserved syntenic associations between human chromosomes 1 and 10p homologues, and between 9 and 11 homologues...
- The DAPI banded karyotype of the domestic dog (Canis familiaris) generated using chromosome-specific paint probesM Breen
Animal Health Trust, Kentford, Suffolk, UK
Chromosome Res 7:401-6. 1999..These data will facilitate the accurate assignment of FISH-mapped loci to all chromosomes comprising the karyotype and form the basis for an agreed standard of the dog karyotype...
- Zoo-FISH analysis: the American mink (Mustela vison) closely resembles the cat karyotypeH Hameister
Abteilung Medizinische Genetik, Universitat Ulm
Chromosome Res 5:5-11. 1997..The mink arrangement proved to be very similar to the arrangement found in the cat, thus corroborating the well-known high karyotype conservation described for Feloidea...
- Detection of submicroscopic deletions in band 17p13 in patients with the Miller-Dieker syndromeC E Schwartz
Greenwood Genetic Center, SC 29646
Am J Hum Genet 43:597-604. 1988..The most distal locus, defined by p144D6, was present in one MDS patient, possibly defining the distal limits of the MDS region in band 17p13.3. None of these loci were absent in one case of lissencephaly without MDS...
- Microdissection based high resolution multicolor banding for all 24 human chromosomesThomas Liehr
Institute of Human Genetics and Anthropology, Kollegiengasse 10, D 07740 Jena, Germany
Int J Mol Med 9:335-9. 2002..In conclusion, the MCB-technique is a high resolution alternative to other FISH based chromosome banding approaches and suited to clarify, which changes appeared in complex chromosomal rearrangements.
- Amplification of AML1 in childhood acute lymphoblastic leukemiasP Dal Cin
Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Genes Chromosomes Cancer 30:407-9. 2001..It remains to be elucidated whether this amplification results in up-regulation of the normal AML1 gene product or a potentially mutant AML1 transcript...
- Comparative FISH mapping in river buffalo and sheep chromosomes: assignment of forty autosomal type I loci from sixteen human chromosomesL Iannuzzi
National Research Council CNR, Laboratory of Animal Cytogenetics and Gene Mapping, IABBAM, Naples Italy
Cytogenet Cell Genet 94:43-8. 2001....
- Comparison of chromosome banding analysis, interphase- and hypermetaphase-FISH, qualitative and quantitative PCR for diagnosis and for follow-up in chronic myeloid leukemia: a study on 350 casesC Schoch
Department of Internal Medicine III, University Hospital Grosshadern, Ludwig Maximilians University, Munich, Germany
Leukemia 16:53-9. 2002..b>Chromosome banding analysis (CA) is still the gold standard but other techniques like Southern blot, fluorescence in situ ..
- Low rate of genomic repatterning in Xenarthra inferred from chromosome painting dataG Dobigny
Evolutionary Genomics Group, Department of Botany and Zoology, University of Stellenbosch, Private Bag X1, Matieland 7602, South Africa
Chromosome Res 13:651-63. 2005..Finally, our results provide a glimpse of a likely ancestral karyotype for the extant Xenarthra, a pivotal group for understanding eutherian genome evolution...
- Reciprocal chromosome painting among human, aardvark, and elephant (superorder Afrotheria) reveals the likely eutherian ancestral karyotypeF Yang
Centre for Veterinary Science, University of Cambridge, Cambridge CB3 0ES, United Kingdom
Proc Natl Acad Sci U S A 100:1062-6. 2003....
- Comparison of the human with the sheep genomes by use of human chromosome-specific painting probesL Iannuzzi
National Research Council, I A B B A M, Via Argine 1085, 80147 Naples, Italy
Mamm Genome 10:719-23. 1999..A total of 48 human chromosome segments were detected in sheep chromosomes. Comparisons with sheep gene mapping data available and previous Zoo-FISH data obtained in sheep, cattle, and river buffalo were performed...
- Cytogenetic analysis of the neotropical spider Nephilengys cruentata (Araneomorphae, Tetragnathidae): standard staining nors, C-bands and base-specific fluorochromesD Araujo
Universidade Estadual Paulista, UNESP, Instituto de Biociencias, Departamento de Biologia, Av 24A, 1515, CEP 13506 900, Rio Claro, SP, Brazil
Braz J Biol 65:193-202. 2005..In N. cruentata the fluorochromes DAPI/DA, DAPI/MM and CMA3/DA revealed that the constitutive heterochromatin is rich in AT bases and the NORs possess repetitive sequences of GC bases...
- Conserved chromosome segments in Hylobates hoolock revealed by human and H. leucogenys paint probesW Nie
Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, Yunnan, Peoples Republic of China
Cytogenet Cell Genet 92:248-53. 2001..hoolock more closely resembles the ancestral karyotype of Hylobates, rather than the karyotype of H. leucogenys...
- A chromosome painting test of the basal eutherian karyotypeMarta Svartman
Comparative Molecular Cytogenetics Core, Genetics Branch, National Cancer Institute Frederick, Frederick, MD 21702, USA
Chromosome Res 12:45-53. 2004..Current attempts lack legitimacy until this situation is corrected...
- ZOO-FISH and R-banding reveal extensive conservation of human chromosome regions in euchromatic regions of river buffalo chromosomesL Iannuzzi
National Research Council CNR, I A B B A M, Naples Italy
Cytogenet Cell Genet 82:210-4. 1998..Thus, these river buffalo chromosome arms can serve as markers to resolve discrepancies in the nomenclature of cattle and related species...
- Highly conserved chromosomes in an Asian squirrel (Menetes berdmorei, Rodentia: Sciuridae) as demonstrated by ZOO-FISH with human probesF Richard
UMR 147 CNRS, Institut Curie, Section Recherche, 26 Rue d Ulm, 75248 Paris Cedex 05, France
Chromosome Res 11:597-603. 2003..Sciurinae chromosomes appear to be much closer to those of non-rodent mammals than those of Muridae and Cricetidae species studied so far. Thus, they provide an interesting tool to link the rodent genome to those of other mammals...
- A duplicated gene in the breakpoint regions of the 7q11.23 Williams-Beuren syndrome deletion encodes the initiator binding protein TFII-I and BAP-135, a phosphorylation target of BTKL A Perez Jurado
Unidad de Gen etica, Hospital Ni no Jes us, Madred, Spain Stanford University Medical Center
Hum Mol Genet 7:325-34. 1998..Hemizygosity for GTF2I may also contribute to the WBS phenotype...
- Localisation of aphidicolin-induced break points in Holstein-Friesian cattle (Bos taurus) using RBG-bandingViviana Rodriguez
Department of Cell and Molecular Biology, Genetic Section, Laboratory of Genetics Analysis in Domestic Animals, Faculty of Veterinary, UDELAR, A Lasplaces 1550 CP 11600, Montevideo, Uruguay
Genet Sel Evol 34:649-56. 2002..The Pearson correlation test showed a positive association between chromosome length and the number of fragile sites (r=0.54). On the contrary, 21 FS were identified on negative R bands while 9 FS were located on positive R bands...
- Phylogenetic inferences of Atelinae (Platyrrhini) based on multi-directional chromosome painting in Brachyteles arachnoides, Ateles paniscus paniscus and Ateles b. marginatusE H C de Oliveira
Institut für Anthropologie und Humangenetik, Department Biologie II, Ludwig Maximilians Universitat, Munich, Germany
Cytogenet Genome Res 108:183-90. 2005..The chromosomal data support a re-evaluation of the taxonomic status of Ateles b. hybridus...
- Clinical and molecular characterization of individuals with 18p deletion: a genotype-phenotype correlationUlrika Wester
Unit of Paediatrics, Department of Women and Children s Health, Uppsala University, Sweden
Am J Med Genet A 140:1164-71. 2006..1 and 18p11.21. The children with a breakpoint at 18p11.1 had all a broad face, which was observed in only one of those with a more distal breakpoint, otherwise no genotype-phenotype correlation of the features was observed...
- Comparative genome analysis in American marsupials: chromosome banding and in-situ hybridizationM Svartman
Departamento de Biologia, Instituto de Biociencias, Universidade de Sao Paulo, Sao Paulo SP, Brazil
Chromosome Res 7:267-75. 1999..In-situ hybridization with total genomic DNA revealed considerable conservation of the euchromatic portions of the three karyotypes and indicated divergence of repetitive DNA sequences in autosomal heterochromatin...
- A case of azoospermia in a bull carrying a Y-autosome reciprocal translocationL Iannuzzi
National Research Council CNR, IABBAM, Laboratory of Animal Cytogenetics and Gene Mapping, Naples, Italy
Cytogenet Cell Genet 95:225-7. 2001..Analysis on sperm from four different samples revealed azoospermia in the carrier, indicating that the rcp(Y;9) induces sterility in the bull...
- The genome phylogeny of domestic cat, red panda and five mustelid species revealed by comparative chromosome painting and G-bandingWenhui Nie
Key Laboratory of Cellular and Molecular Evolution, The Chinese Academy of Sciences, Kunming, Yunnan, PRC
Chromosome Res 10:209-22. 2002..Our results support a close phylogenetic relationship between the red panda and mustelids. The homology data presented in these maps will allow us to transfer the cat gene mapping data to other unmapped carnivore species...
- Genome-wide oligonucleotide-based array comparative genome hybridization analysis of non-isolated congenital diaphragmatic herniaDaryl A Scott
Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Hum Mol Genet 16:424-30. 2007..This method is more sensitive than G-banded chromosome analysis and may find wide application in screening patients with congenital anomalies...
- Molecular cytogenetic characterization of the EBV-producing cell line B95-8 (Saguinus oedipus, Platyrrhini) by chromosome sorting and paintingS Muller
Institute of Anthropology and Human Genetics, University of Munich LMU, Germany
Chromosome Res 9:689-93. 2001..The multicolour probe set described here will be of special value for further evolutionary studies in New World monkeys...
- Evolution of multiple sex chromosomes in the spider genus Malthonica (Araneae: Agelenidae) indicates unique structure of the spider sex chromosome systemsJiri Kral
Laboratory of Arachnid Cytogenetics, Department of Genetics and Microbiology, Faculty of Science, Charles University in Prague, Vinicna 5, CZ 128 44, Prague 2, Czech Republic
Chromosome Res 15:863-79. 2007..Structural differentiation of newly formed X chromosomes has been facilitated by heterochromatinization of sex chromosome bivalents observed in prophase I of spider females...
- Phenotypic and cytogenetic spectrum of 9p trisomyS A Temtamy
Clinical Genetics Department, Division of Human Genetics and Genome Research, National Research Centre, Egypt
Genet Couns 18:29-48. 2007..We also suggest that dosage effects of genes located in 9pter-q22 contribute to the etiology of Dandy-Walker syndrome. We recommend MRI studies as a routine in all cases with trisomy 9p...
- Chromosome banding in Amphibia. XXV. Karyotype evolution and heterochromatin characterization in Australian Mixophyes (Anura, Myobatrachidae)M Schmid
Department of Human Genetics, Biocenter, University of Wurzburg, Wurzburg, Germany
Cytogenet Genome Res 97:239-53. 2002....
- Patterns of chromosome banding in four nabid species (Heteroptera, Cimicomorpha, Nabidae) with high chromosome number karyotypesS Grozeva
Institute of Zoology, Bulgarian Academy of Sciences, Sofia, Bulgaria
Hereditas 140:99-104. 2004..The present paper provides new information on the genome organization and new cytological markers useful for a better insight into karyotype evolution of nabid species...
- Visualization of interphase chromosomes in postmitotic cells of the human brain by multicolour banding (MCB)I Y Iourov
National Research Center of Mental Health, Russian Academy of Medical Sciences, Moscow 119152, Russia
Chromosome Res 14:223-9. 2006..Thus, cytogenetics is no longer limited in its application to dividing cells, which is a great step forward for brain research...
- A molecular cytogenetic analysis of X chromosome repatterning in the Bovidae: transpositions, inversions, and phylogenetic inferenceT J Robinson
Department of Zoology and Entomology, University of Pretoria, South Africa
Cytogenet Cell Genet 80:179-84. 1998....
- In situ hybridization and chromosome banding in mammalian speciesR Chaves
Department of Genetics and Biotechnology, ICETA UTAD, University of Trásos Montes and Alto Douro, Vila Real, Portugal
Cytogenet Genome Res 96:113-6. 2002b>Chromosome banding is often required in conjunction with fluorescent in situ hybridization of labelled probes for chromosome painting, satellite DNA and low-copy sequences to allow identification of chromosomes and simultaneous probe ..
- Boy with seizures (West syndrome) and distal 7q duplication syndrome due to an unbalanced 7q;9p translocationB Tuysuz
Division of Genetics, Department of Pediatrics, Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey
Genet Couns 19:29-35. 2008..The boy presented typical facial features of the distal 7q duplication syndrome but no genital anomalies attributable to his distal 9p deletion. We assume that the severe epilepsy is likely due to the trisomy 7q...
- Frequent aberrations of chromosome 8 in aggressive B-cell non-Hodgkin lymphomaBarbara Pienkowska-Grela
Cytogenetic Laboratory, The Memorial M Sklodowska Curie Cancer Centre and Institute, Roentgen Str 5, 02 781 Warsaw, Poland
Cancer Genet Cytogenet 156:114-21. 2005..This study indicates that the mechanisms of C-MYC activation involved in BLL can be different from that for the BL...
- Subtelomeric deletions of chromosome 6p: molecular and cytogenetic characterization of three new cases with phenotypic overlap with Ritscher-Schinzel (3C) syndromeCheryl Descipio
Division of Human Genetics and Molecular Biology, The Children s Hospital of Philadelphia, and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Am J Med Genet A 134:3-11. 2005..Three forkhead genes (FOXF1 and FOXQ1 from within the critical region, and FOXC1 proximal to this region) were evaluated as potential candidate disease genes for this disorder. No deletions or disease-causing mutations were identified...
- High-resolution molecular cytogenetic analysis of Wilms tumors highlights diagnostic difficulties among small round cell kidney tumorsYlva Stewénius
Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
Genes Chromosomes Cancer 47:845-52. 2008..The fact that no recurrent translocations were found in the WTs of this study argues against the presence of a frequent pathognomonic translocation in this disease entity...
- Interstitial loss and gain of sequences on chromosome 22 in meningiomas with normal karyotypeAlexandra Prowald
Department of Neurosurgery, Neuro Oncology, Saarland University, D 66421 Homburg, Germany
Int J Oncol 26:385-93. 2005..ii) deletion of the original sequences on chromosome 22, resulting in disomy again (only visible as translocation in metaphase FISH). iii) loss of chromosome 22...
- Molecular cytogenetic analysis of non-small cell lung carcinoma by spectral karyotyping and comparative genomic hybridizationC Luk
Departments of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
Cancer Genet Cytogenet 125:87-99. 2001..The pattern of overall chromosomal changes detected using combinations of molecular cytogenetic analytical methods suggests that it will be easier to detect recurrent subtype-dependent aberrations in NSCLC...
- A patient with isochromosome 18q, radial-thumb aplasia, thrombocytopenia, and an unbalanced 10;18 chromosome translocationTrilochan Sahoo
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
Am J Med Genet A 133:93-8. 2005..This additional rearrangement likely has minimal phenotypic consequences, but does raise the possibility that cryptic translocations of telomeric ends of the deleted arm in isochromosome cases may be more common than appreciated...
- Cytogenetic characterization of the TM4 mouse Sertoli cell line. I. Conventional banding techniques, FISH and SKYM Guttenbach
Department of Human Genetics, , , Germany
Cytogenet Cell Genet 94:71-8. 2001..The results show the usefulness of combining SKY and conventional banding methods for the evaluation of chromosome alterations in widely used cell lines...
- Insights from genomic microarrays into structural chromosome rearrangementsJeroen Knijnenburg
Laboratory for Cytochemistry and Cytometry, Department of Molecular Cell Biology, Leiden University Medical Center LUMC, Leiden, The Netherlands
Am J Med Genet A 132:36-40. 2005..We also showed that array results might impact the recurrence risks for relatives of affected individuals. Our data indicate that chromosome rearrangements frequently involve more breaks than current cytogenetic models assume...
- MOLECULAR AND SOMATIC CELL MAPPING OF DEER MOUSE GENESDUKE ROGERS; Fiscal Year: 1991..pericentric inversions function as a mechanism to protect gene combinations within these regions? 2) Is chromosome banding similarity among species indicative of underlying genic similarity; and 3) Have portions of the mammalian ..
- PHYSICAL MAP OF HUMAN CHROMOSOME 18Uta Francke; Fiscal Year: 1993..will be used to determine whether the type of DNA sequences and chromatin structure underlying the chromosome banding patterns can be correlated with the frequency and sites of meiotic crossover events...
- Development of Clinically Useful Single Copy FISH ProbesPETER ROGAN; Fiscal Year: 2005..FISH) is a diagnostic test that distinguishes chromosomal abnormalities not evident by routine chromosome banding. By tagging and hybridizing defined DNA sequences with fluorochromes, abnormalities can be detected for ..
- MOLECULAR CYTOGENETIC ANALYSIS OF HUMAN CHROMOSOMESJAY GEORGE; Fiscal Year: 1992..been performed by specially trained technologists and professionals with specific expertise in a variety of chromosome banding methods and their interpretation...
- OBJECTIVE ANALYSIS OF CHROMOSOME BANDING PATTERNSKenneth Castleman; Fiscal Year: 1999..chromosome analysis instruments, this will allow objective characterization and convenient display of chromosome banding patterns, and quantitative comparison of chromosomes to normal and abnormal prototypes and to each other...
- WAVELET ENHANCEMENT OF CHROMOSOME BANDING PATTERNSQiang Wu; Fiscal Year: 2000..aims to develop and commercialize significantly improved software for digital enhancement of the detail of chromosome banding patterns in microscopic images...
- E. COLI BASED VECTORS FOR GENE DELIVERY TO HUMAN CELLSPETER WARBURTON; Fiscal Year: 2002..These studies propose to develop E. coli-based HAC vectors for human gene therapy that encompass novel approaches for gene delivery, accurate gene expression, and mitotic stability. ..
- Chromosome Analysis of Single CellsBrynn Levy; Fiscal Year: 2007..abstract_text> ..
- MOLECULAR GENETICS OF AUTISMThomas Wassink; Fiscal Year: 2006..The WNT2 findings will be further examined in two-independent patient samples. ..
- Biacore T100Jeffrey Toretsky; Fiscal Year: 2006..These enhanced capabilities of the T100 will allow projects investigating many types of biologic processes to advance. ..
- Nuclear and genomic organization of gene expressionJeanne Lawrence; Fiscal Year: 2006..Hypotheses tested have potential to elucidate the functional evolution of the karyotype and such features as cytogenetic bands and conserved gene clusters, which may associate with distinct intranuclear compartments. ..
- Lipid Imbalance in CF: Potential CFTR DysfunctionJulie Hoover Fong; Fiscal Year: 2006..abstract_text> ..
- ANALYSIS OF HUMAN CHROMOSOME 13Q NEOCENTROMERE FORMATIONPETER WARBURTON; Fiscal Year: 2007..Investigation of human centromere structure, function and formation will greatly facilitate the construction of artificial human chromosomes for use as autonomous gene expression vectors. ..
- AN ANIMAL MODEL OF GLUCOCORTICOID RESISTANCEJonathan Scammell; Fiscal Year: 2007..In summary, these studies will provide important insight into the physiological role of FKBP51 while at the same time adding substantial value to the Squirrel Monkey Resource at the University of South Alabama. ..
- Analysis of transcription in lens using tiled microarrays (ChIP on chip)Ales Cvekl; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable]..
- Molecular Cytogenetic Tools for the ZebrafishCharles Lee; Fiscal Year: 2008..This tool will be used to identify genomic DNA gains and losses which could lead to the identification of novel oncogenes and tumor-suppresor genes that lead to tumorigenesis in many zebrafish mutants. ..
- Development of Novel Regimens for the Prevention of Chronic Renal FailureCARL SHELLEY; Fiscal Year: 2008..In this way we expect to provide proof-of-principal for new therapeutic regimens that reduce the ability of hypoxia to cause CRF. ..
- The repetitive DNA structure of the human genomePETER WARBURTON; Fiscal Year: 2009..The studies proposed in this application will facilitate both computational and biological approaches to genomics and provide a unique analysis of a large and relatively neglected portion of our DNA sequence. ..
- Akt Inhibitors to Treat Ewing's SarcomaJeffrey Toretsky; Fiscal Year: 2005..Our findings from this Phase I Sun will hopefully lead to a key compound that can be further developed in a Phase II STTR ultimately leading to clinical trials in patients with ESFT. ..
- Imprinted SnoRNA Genes in the PWS deletion RegionUta Francke; Fiscal Year: 2005..abstract_text> ..
- Conference on Genotype to Phenotype: Focus on DiseaseUta Francke; Fiscal Year: 2002..techniques, resources and approaches as they arise in different disciplines. In scope and orientation, this conference is unlike any others that have been organized recently. It is timely and its impact will likely be high. ..
- PROBING FUNCTIONAL ORGANIZATION WITHIN THE NUCLEUSJeanne Lawrence; Fiscal Year: 2001..It further has potential for diagnosing and elucidating the molecular pathology of splicing defects in OI Type I and other genetic diseases. ..
- MOLECULAR MECHANISMS LEADING TO RETT SYNDROMEUta Francke; Fiscal Year: 2002..Newborn screening programs could identify presymptomatic mutation carriers. One the causative genetic mechanism is known, understanding of the pathophysiology may lead to early therapeutic intervention. ..
- A MULTI-FACETED SEARCH FOR AUTISM DISEASE GENESThomas Wassink; Fiscal Year: 2004..Taken together, the training plan and research proposal provide for a breadth of training, the potential for meaningful discovery, and support for the establishment of an independent research career. ..
- Full karyotype single cell interphase analysisSantiago Munne; Fiscal Year: 2005..In phase-I we propose to develop two of the three sets of probes, and to test that these probes will work with 90% efficiency after three rounds of hybridization in single polar bodies. ..
- CHARACTERIZATION OF A NEW GENE IN P53 MUTANT LFS FAMILYZAKI SHERIF; Fiscal Year: 2004..These studies of LFS should delineate the correlation between genotype and phenotype in LFS and contribute to the general understanding of the processes leading to carcinogenesis. ..
- A 13q32 BAC Microarray for chromosome function analysisPETER WARBURTON; Fiscal Year: 2004..The development of these types of high-density genomic microarrays will be a major step towards understanding the genomic organization and role of non-protein coding functional DNA elements in our cells. ..
- Genetic Determinants of Brain Structure and Disease Risk in SchizophreniaThomas H Wassink; Fiscal Year: 2010....
- Function of Genes in Williams Syndrome Deletion RegionUta Francke; Fiscal Year: 2005....
- Signaling Pathways that Determine Ewings Sarcoma OutcomeJeffrey Toretsky; Fiscal Year: 2008..Clearly, if PTPL1 is validated as a supportive oncoprotein and the pathways modulated by PTPL1 are identified, patients with many other tumors that rely on IGF-IR signaling including breast carcinoma could benefit from our findings. ..
- E coli-based vectors for BAC delivery to mammalian cellsPETER WARBURTON; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Canine Brain Tumors - A New Model for Gene DiscoveryMatthew Breen; Fiscal Year: 2006..Characterization of these genetic loci will help to improve the definition of molecular risk and prognosis of human and canine brain tumors, with a potentially major impact on human health. ..
- MID ATLANTIC CANCER GENETICS NETWORKConstance Griffin; Fiscal Year: 2005....
- Array Based CGH for Genome-Wide Analysis of Wilms' TumorNorma Nowak; Fiscal Year: 2004..We will identify the recurrent copy number aberrations present in our WT bank, tile the implicated chromosomal regions on WT subarrays, and identify candidate genes involved in WT and kidney development. ..
- Biomarkers for the Progression of Head and Neck Squamous Cell CarcinomaNorma Nowak; Fiscal Year: 2009..Clearly, the analysis will also lead to a better understanding of the genetic events leading to invasive HNSCC. ..
- Affymetrix 437 ArrayerNorma Nowak; Fiscal Year: 2002..The requested instrumentation will afford the DNA Microarray and Genomics Resource with the capacity to continue to provide high quality custom genomic and expression arrays. ..
- Mapping and Characterization of Epilespy GenesNATALIA LEACH; Fiscal Year: 2006..abstract_text> ..