physical chromosome mapping


Summary: Mapping of the linear order of genes on a chromosome with units indicating their distances by using methods other than genetic recombination. These methods include nucleotide sequencing, overlapping deletions in polytene chromosomes, and electron micrography of heteroduplex DNA. (From King & Stansfield, A Dictionary of Genetics, 5th ed)

Top Publications

  1. ncbi Genome analysis at different ploidy levels allows cloning of the powdery mildew resistance gene Pm3b from hexaploid wheat
    Nabila Yahiaoui
    Institute of Plant Biology, University of Zurich, Zollikerstrasse 107, 8008 Zurich, Switzerland
    Plant J 37:528-38. 2004
  2. ncbi The sequence of the human genome
    J C Venter
    Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA
    Science 291:1304-51. 2001
  3. ncbi Initial sequencing and comparative analysis of the mouse genome
    Robert H Waterston
    Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA
    Nature 420:520-62. 2002
  4. ncbi A physical map of the 1-gigabase bread wheat chromosome 3B
    Etienne Paux
    Institut National de la Recherche Agronomique, Université Blaise Pascal INRA UBP, UMR 1095, Genetics Diversity and Ecophysiology of Cereals, Clermont Ferrand, France
    Science 322:101-4. 2008
  5. ncbi The genome sequence of the malaria mosquito Anopheles gambiae
    Robert A Holt
    Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA
    Science 298:129-49. 2002
  6. ncbi Microsatellite-based deletion bin system for the establishment of genetic-physical map relationships in wheat (Triticum aestivum L.)
    Pierre Sourdille
    UMR INRA UBP Amélioration et Santé des Plantes, 234, avenue du Brézet, 63039 Clermont Ferrand, France
    Funct Integr Genomics 4:12-25. 2004
  7. ncbi Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype
    Olivier Jaillon
    UMR 8030 Genoscope, CNRS and Université d Evry, 2 rue Gaston Cremieux, 91057 Evry Cedex, France
    Nature 431:946-57. 2004
  8. pmc The physical and genetic framework of the maize B73 genome
    Fusheng Wei
    Arizona Genomics Institute, Department of Plant Sciences, BIO5 Institute for Collaborative Research, University of Arizona, Tucson, Arizona, United States of America
    PLoS Genet 5:e1000715. 2009
  9. ncbi An overview of the apple genome through BAC end sequence analysis
    Yuepeng Han
    Department of Natural Resources and Environmental Sciences, University of Illinois, Urbana, IL 61801, USA
    Plant Mol Biol 67:581-8. 2008
  10. pmc Distribution of microsatellites in the genome of Medicago truncatula: a resource of genetic markers that integrate genetic and physical maps
    Jeong Hwan Mun
    Department of Plant Pathology, University of California, Davis 95616, USA
    Genetics 172:2541-55. 2006

Research Grants

Detail Information

Publications247 found, 100 shown here

  1. ncbi Genome analysis at different ploidy levels allows cloning of the powdery mildew resistance gene Pm3b from hexaploid wheat
    Nabila Yahiaoui
    Institute of Plant Biology, University of Zurich, Zollikerstrasse 107, 8008 Zurich, Switzerland
    Plant J 37:528-38. 2004
    ..These results demonstrate that the candidate gene, a member of the coiled-coil nucleotide binding site leucine-rich repeat (NBS-LRR) type of disease resistance genes, is the Pm3b gene...
  2. ncbi The sequence of the human genome
    J C Venter
    Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA
    Science 291:1304-51. 2001
    ..Less than 1% of all SNPs resulted in variation in proteins, but the task of determining which SNPs have functional consequences remains an open challenge...
  3. ncbi Initial sequencing and comparative analysis of the mouse genome
    Robert H Waterston
    Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA
    Nature 420:520-62. 2002
  4. ncbi A physical map of the 1-gigabase bread wheat chromosome 3B
    Etienne Paux
    Institut National de la Recherche Agronomique, Université Blaise Pascal INRA UBP, UMR 1095, Genetics Diversity and Ecophysiology of Cereals, Clermont Ferrand, France
    Science 322:101-4. 2008
    ..This physical map establishes a template for the remaining wheat chromosomes and demonstrates the feasibility of constructing physical maps in large, complex, polyploid genomes with a chromosome-based approach...
  5. ncbi The genome sequence of the malaria mosquito Anopheles gambiae
    Robert A Holt
    Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA
    Science 298:129-49. 2002
    ..An expressed sequence tag analysis of genes regulated by blood feeding provided insights into the physiological adaptations of a hematophagous insect...
  6. ncbi Microsatellite-based deletion bin system for the establishment of genetic-physical map relationships in wheat (Triticum aestivum L.)
    Pierre Sourdille
    UMR INRA UBP Amélioration et Santé des Plantes, 234, avenue du Brézet, 63039 Clermont Ferrand, France
    Funct Integr Genomics 4:12-25. 2004
  7. ncbi Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype
    Olivier Jaillon
    UMR 8030 Genoscope, CNRS and Université d Evry, 2 rue Gaston Cremieux, 91057 Evry Cedex, France
    Nature 431:946-57. 2004
  8. pmc The physical and genetic framework of the maize B73 genome
    Fusheng Wei
    Arizona Genomics Institute, Department of Plant Sciences, BIO5 Institute for Collaborative Research, University of Arizona, Tucson, Arizona, United States of America
    PLoS Genet 5:e1000715. 2009
    ..Finally we used all available physical, sequence, genetic, and optical data to generate a golden path (AGP) of chromosome-based pseudomolecules, herein referred to as the B73 Reference Genome Sequence version 1 (B73 RefGen_v1)...
  9. ncbi An overview of the apple genome through BAC end sequence analysis
    Yuepeng Han
    Department of Natural Resources and Environmental Sciences, University of Illinois, Urbana, IL 61801, USA
    Plant Mol Biol 67:581-8. 2008
    ..BAC end sequencing can be used to anchor a small proportion of the apple genome to the Populus and possibly to the Arabidopsis genomes...
  10. pmc Distribution of microsatellites in the genome of Medicago truncatula: a resource of genetic markers that integrate genetic and physical maps
    Jeong Hwan Mun
    Department of Plant Pathology, University of California, Davis 95616, USA
    Genetics 172:2541-55. 2006
    ..A total of 378 genetic markers could be integrated with sequenced BAC clones, anchoring 274 physical contigs that represent 174 Mbp of the genome and composing an estimated 70% of the euchromatic gene space...
  11. ncbi A whole-genome assembly of Drosophila
    E W Myers
    Celera Genomics, Inc, 45 West Gude Drive, Rockville, MD 20850, USA
    Science 287:2196-204. 2000
    ..99% without manual curation. As such, this initial reconstruction of the Drosophila sequence should be of substantial value to the scientific community...
  12. pmc Physical mapping and BAC-end sequence analysis provide initial insights into the flax (Linum usitatissimum L.) genome
    Raja Ragupathy
    Cereal Research Centre, Agriculture and Agri Food Canada, Winnipeg, MB, Canada
    BMC Genomics 12:217. 2011
    ..We report here the first genome-wide physical map of flax and the generation and analysis of BAC-end sequences (BES) from 43,776 clones, providing initial insights into the genome...
  13. ncbi Whole-genome shotgun assembly and analysis of the genome of Fugu rubripes
    Samuel Aparicio
    Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609
    Science 297:1301-10. 2002
    ..Conserved linkages between Fugu and human genes indicate the preservation of chromosomal segments from the common vertebrate ancestor, but with considerable scrambling of gene order...
  14. ncbi Development of chromosome-specific BAC resources for genomics of bread wheat
    J Safar
    Laboratory of Molecular Cytogenetics and Cytometry, Institute of Experimental Botany, Olomouc, Czech Republic
    Cytogenet Genome Res 129:211-23. 2010
    ..Each chromosome (arm)-specific library is composed of a manageable number of clones, and so represents a practical tool in the area of wheat genomics...
  15. ncbi Sequencing and assembly of low copy and genic regions of isolated Triticum aestivum chromosome arm 7DS
    Paul J Berkman
    School of Land, Crop and Food Sciences and Australian Centre for Plant Functional Genomics, University of Queensland, Brisbane, QLD, Australia
    Plant Biotechnol J 9:768-75. 2011 Our results suggest that the sequencing of isolated chromosome arms can provide valuable information of the gene content of wheat and is a step towards whole-genome sequencing and variation discovery in this important crop...
  16. pmc A single molecule scaffold for the maize genome
    Shiguo Zhou
    Laboratory for Molecular and Computational Genomics, Department of Chemistry, Laboratory of Genetics, UW Biotechnology Center, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS Genet 5:e1000711. 2009
  17. ncbi Current status and the future of fluorescence in situ hybridization (FISH) in plant genome research
    Jiming Jiang
    Department of Horticulture, University of Wisconsin, Madison, WI 53706, USA
    Genome 49:1057-68. 2006
    ..FISH coupled with immunoassays will be increasingly used to study features of chromatin at the cytological level that control expression and regulation of genes...
  18. ncbi A BAC-based physical map of the channel catfish genome
    Peng Xu
    The Fish Molecular Genetics and Biotechnology Laboratory, Department of Fisheries and Allied Aquacultures, and Program of Cell and Molecular Biosciences, Aquatic Genomics Unit, Auburn University, Auburn, AL 36849, USA
    Genomics 90:380-8. 2007
    ..The presented physical map should greatly enhance genome research in the catfish, particularly aiding in the identification of genomic regions containing genes underlying important performance traits...
  19. pmc A BAC-based physical map of Zhikong scallop (Chlamys farreri Jones et Preston)
    Xiaojun Zhang
    Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China
    PLoS ONE 6:e27612. 2011
  20. pmc The human transcriptome map reveals extremes in gene density, intron length, GC content, and repeat pattern for domains of highly and weakly expressed genes
    Rogier Versteeg
    Department of Human Genetics, Academic Medical Center, University of Amsterdam, 1100DE Amsterdam, The Netherlands
    Genome Res 13:1998-2004. 2003
    ..Ridges are therefore an integral part of a higher order structure in the genome related to transcriptional regulation...
  21. pmc Gramene, a tool for grass genomics
    Doreen H Ware
    Cold Spring Harbor Laboratory, New York 11724, USA
    Plant Physiol 130:1606-13. 2002
    ..In this paper, we present a brief overview of the search tools available to the plant research community in Gramene...
  22. ncbi The S haplotype-specific F-box protein gene, SFB, is defective in self-compatible haplotypes of Prunus avium and P. mume
    Koichiro Ushijima
    Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
    Plant J 39:573-86. 2004
  23. ncbi Vrn-D4 is a vernalization gene located on the centromeric region of chromosome 5D in hexaploid wheat
    Tetsuya Yoshida
    Graduate School of Natural Science and Technology, Okayama University, 1 1 1, Tsushima Naka, Kita ku, Okayama 700 8530, Japan
    Theor Appl Genet 120:543-52. 2010
    ..The precise mapping and characterization of Vrn-D4 presented here represent a first step toward the positional cloning of this gene...
  24. pmc A draft physical map of a D-genome cotton species (Gossypium raimondii)
    Lifeng Lin
    Plant Genome Mapping Laboratory, University of Georgia, Athens, GA 30605, USA
    BMC Genomics 11:395. 2010
    ..Toward the long-term goal of characterizing the spectrum of diversity among cotton genomes, the worldwide cotton community has prioritized the D genome progenitor Gossypium raimondii for complete sequencing...
  25. ncbi Diversity arrays technology (DArT) for high-throughput profiling of the hexaploid wheat genome
    Mona Akbari
    Triticarte P L, 1 Wilf Crane Crescent, Yarralumla, Canberra, ACT, 2600, Australia
    Theor Appl Genet 113:1409-20. 2006
  26. ncbi FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4
    M H Xie
    Department of Molecular Biology, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Cytokine 11:729-35. 1999
    ..FGF-19 message is expressed in several tissues including fetal cartilage, skin, and retina, as well as adult gall bladder and is overexpressed in a colon adenocarcinoma cell line...
  27. pmc Demarcating the gene-rich regions of the wheat genome
    Mustafa Erayman
    Washington State University, Pullman, WA 99164, USA
    Nucleic Acids Res 32:3546-65. 2004
    ..More than 30% of the wheat genes are in recombination-poor regions thus are inaccessible to map-based cloning...
  28. pmc Chromosome complement of the fungal plant pathogen Fusarium graminearum based on genetic and physical mapping and cytological observations
    L R Gale
    Cereal Disease Laboratory, U S Department of Agriculture, Agricultural Research Service, St Paul, Minnesota 55108, USA
    Genetics 171:985-1001. 2005
    ..A chromosome number of four was confirmed by cytological karyotyping. Further analysis of the genetic map data identified variation in recombination rate in different genomic regions that often spanned several hundred kilobases...
  29. ncbi A common inversion under selection in Europeans
    Hreinn Stefansson
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 37:129-37. 2005
    ..Here we show that the H2 lineage is undergoing positive selection in the Icelandic population, such that carrier females have more children and have higher recombination rates than noncarriers...
  30. pmc Generation of a BAC-based physical map of the melon genome
    Víctor M González
    Molecular Genetics Department, Center for Research in Agricultural Genomics CRAG CSIC IRTA UAB, Jordi Girona, 18 26, 08034 Barcelona, Spain
    BMC Genomics 11:339. 2010
    ..A BAC-based melon physical map will be a useful tool to help assemble and refine the draft genome data that is being produced...
  31. pmc The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics
    Lincoln D Stein
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    PLoS Biol 1:E45. 2003
    ..elegans genome. Based on similarity to C. briggsae, we found strong evidence for 1,300 new C. elegans genes. In addition, comparisons of the two genomes will help to understand the evolutionary forces that mold nematode genomes...
  32. ncbi The human transcriptome map: clustering of highly expressed genes in chromosomal domains
    H Caron
    Department of Human Genetics, Department of Pediatric Oncology, Emma Children's Hospital, Academic Medical Center, University of Amsterdam, Post Office Box 22700, 1100 DE Amsterdam, Netherlands
    Science 291:1289-92. 2001
    ..The map reveals a clustering of highly expressed genes to specific chromosomal regions. It provides a tool to search for genes that are overexpressed or silenced in cancer...
  33. pmc Identical functional organization of nonpolytene and polytene chromosomes in Drosophila melanogaster
    Tatyana Yu Vatolina
    Institute of Molecular and Cellular Biology of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
    PLoS ONE 6:e25960. 2011
    ..As appeared, origin recognition complexes are located almost totally in the interbands of chromosomes...
  34. ncbi A diagnostic genetic test for the physical mapping of germline rearrangements in the susceptibility breast cancer genes BRCA1 and BRCA2
    Kevin Cheeseman
    Genomic Vision, 80 84 rue des Meuniers, Bagneux, Paris, France
    Hum Mutat 33:998-1009. 2012
    ..We propose the developed genetic test as a valuable tool to screen large rearrangements in BRCA1 and BRCA2 to be combined in clinical settings with an assay capable of detecting small mutations...
  35. ncbi Dynamic intra-japonica subspecies variation and resource application
    Haiyan Lin
    National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, China
    Mol Plant 5:218-30. 2012
    ..ZH11 BAC clones can be browsed, searched, and obtained at our website,
  36. pmc Comparative physical maps derived from BAC end sequences of tilapia (Oreochromis niloticus)
    Lucile Soler
    CIRAD PERSYST, Aquaculture Research Unit, TA B 20 A, Campus International de Baillarguet, 34398 Montpellier Cedex 5, France
    BMC Genomics 11:636. 2010
    ..Here we analyze BAC end-sequences to develop comparative physical maps, and estimate the number of genome rearrangements, between tilapia and other model fish species...
  37. pmc Integration of physical and genetic maps in apple confirms whole-genome and segmental duplications in the apple genome
    Yuepeng Han
    Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences, Moshan, Wuhan, 430074, PR China
    J Exp Bot 62:5117-30. 2011
    ..These findings demonstrated the presence of both genome-wide and segmental duplications in the apple genome and provided further insights into the complex polyploid ancestral origin of the apple...
  38. ncbi Cross-genome map based dissection of a nitrogen use efficiency ortho-metaQTL in bread wheat unravels concerted cereal genome evolution
    Umar Masood Quraishi
    INRA Université Blaise Pascal UMR 1095 GDEC, Domaine de Crouelle, 234 avenue du Brezet, 63100 Clermont Ferrand, France
    Plant J 65:745-56. 2011
    ..We propose an evolutionary model for the NUE locus in cereals from a common ancestral region, involving species specific shuffling events such as gene deletion, inversion, transposition and the invasion of repetitive elements...
  39. ncbi The Rpi-blb2 gene from Solanum bulbocastanum is an Mi-1 gene homolog conferring broad-spectrum late blight resistance in potato
    Edwin A G van der Vossen
    Plant Research International BV, PO Box 16, 6700 AA Wageningen, The Netherlands
    Plant J 44:208-22. 2005
    ..The contrasting evolutionary dynamics of the Rpi-blb2/Mi-1 loci in the two related genomes may reflect the opposite evolutionary potentials of the interacting pathogens...
  40. pmc The stem rust resistance gene Rpg5 encodes a protein with nucleotide-binding-site, leucine-rich, and protein kinase domains
    R Brueggeman
    Department of Crop and Soil Science, Washington State University, Pullman, WA 99164, USA
    Proc Natl Acad Sci U S A 105:14970-5. 2008
    ..Involvement of actin depolymerizing factor genes in nonhost resistance has been documented, but discovery of their role in gene-for-gene interaction would be novel and needs to be further substantiated...
  41. ncbi Molecular dissection of Tomato leaf curl virus resistance in tomato line TY172 derived from Solanum peruvianum
    Ilana Anbinder
    Institute of Plant Sciences, Agricultural Research Organization, The Volcani Center, Bet Dagan, Israel
    Theor Appl Genet 119:519-30. 2009
    ..The minor QTLs, originated either from the resistant or susceptible parents, were mapped to chromosomes 1, 7, 9 and 11, and contributed 12% to the variation in symptom severity in addition to Ty-5...
  42. pmc Alignment of genetic and physical maps of Gibberella zeae
    Jungkwan Lee
    USDA ARS Plant Science and Entomology Research Unit, Throckmorton Plant Sciences Center, Kansas State University, Manhattan, KS 66506 5502, USA
    Appl Environ Microbiol 74:2349-59. 2008
    ..g., fertility and fitness) and genetic features (e.g., centromeres and recombination frequency) that do not have a known molecular signature in the genome...
  43. ncbi Exploiting plant somatic radiation hybrids for physical mapping of expressed sequence tags
    J Wardrop
    Scottish Crop Research Institute, Invergowrie, Dundee, DD2 5DA, UK
    Theor Appl Genet 108:343-8. 2004
    ..Using panels of hybrids and ESTs, donor DNA retention and individual marker retention frequencies for the expressed portion of the barley genome in the hybrids were estimated...
  44. pmc The barley stem rust-resistance gene Rpg1 is a novel disease-resistance gene with homology to receptor kinases
    R Brueggeman
    Department of Crop and Soil Sciences, Washington State University, Pullman, WA 99164 6420, USA
    Proc Natl Acad Sci U S A 99:9328-33. 2002
    ..identifying it as the Rpg1 gene. Rpg1 encodes a receptor kinase-like protein with two tandem protein kinase domains, a novel structure for a plant disease-resistance gene. Thus, it may represent a new class of plant resistance genes...
  45. pmc An international reference consensus genetic map with 897 marker loci based on 11 mapping populations for tetraploid groundnut (Arachis hypogaea L.)
    Bhimana Gautami
    Center of Excellence in Genomics, International Crops Research Institute for the Semi Arid Tropics ICRISAT, Patancheru, India
    PLoS ONE 7:e41213. 2012
  46. pmc Genomic tools development for Aquilegia: construction of a BAC-based physical map
    Guang Chen Fang
    Department of Genetics and Biochemistry, Clemson University, SC 29634, USA
    BMC Genomics 11:621. 2010
    ..To gain insights into the genome structure and facilitate gene identification, comparative genomics and whole-genome shotgun sequencing assembly, BAC-based genomics resources are of crucial importance...
  47. ncbi Integration of genetic, physical, and cytogenetic maps for Brassica rapa chromosome A7
    Z Xiong
    Division of Biological Sciences, Christopher S Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA
    Cytogenet Genome Res 129:190-8. 2010
    ..napus to demonstrate that this approach can facilitate studies of genome evolution by integrating the genetic, physical, and cytogenetic maps among closely related species of Brassica...
  48. pmc A BAC/BIBAC-based physical map of chickpea, Cicer arietinum L
    Xiaojun Zhang
    Department of Soil and Crop Sciences, Texas A and M University, College Station, Texas 77843 2474, USA
    BMC Genomics 11:501. 2010
    ..The availability of a genome-wide physical map allows rapid fine mapping of QTL, development of high-density genome maps, and sequencing of the entire genome. However, no such a physical map has been developed in chickpea...
  49. pmc Regulatory network construction in Arabidopsis by using genome-wide gene expression quantitative trait loci
    Joost J B Keurentjes
    Laboratory of Genetics, Wageningen University, Arboretumlaan 4, NL 6703 BD Wageningen, The Netherlands
    Proc Natl Acad Sci U S A 104:1708-13. 2007
    ..Results that revealed clusters of coregulated genes and their most likely regulators were in agreement with published data, and unknown relationships could be predicted...
  50. pmc Mapping and sequencing of structural variation from eight human genomes
    Jeffrey M Kidd
    Department of Genome Sciences and Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA
    Nature 453:56-64. 2008
    ..These data provide the first high-resolution sequence map of human structural variation--a standard for genotyping platforms and a prelude to future individual genome sequencing projects...
  51. pmc Integration of the Aedes aegypti mosquito genetic linkage and physical maps
    S E Brown
    Department of Bioagricultural Sciences and Pest Management, College of Agricultural Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    Genetics 157:1299-305. 2001
    ..Since the genetic linkage map is a RFLP cDNA-based map, these data also provide a minimal estimate for the size of the euchromatic regions. The implications of these findings on positional cloning in A. aegypti are discussed...
  52. pmc Polytene chromosomal maps of 11 Drosophila species: the order of genomic scaffolds inferred from genetic and physical maps
    Stephen W Schaeffer
    Department of Biology and Institute of Molecular Evolutionary Genetics, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Genetics 179:1601-55. 2008
    ..Despite the conservation of genes within homologous chromosome arms across species, the karyotypes of these species have changed through the fusion of chromosomal arms followed by subsequent rearrangement events...
  53. ncbi Integration of animal linkage and BAC contig maps using overgo hybridization
    M N Romanov
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Mich, USA
    Cytogenet Genome Res 102:277-81. 2003
    ..These data are publicly available, and they have been used in the assembly of a first generation BAC contig map of the chicken genome...
  54. ncbi A new interspecific, Gossypium hirsutum x G. barbadense, RIL population: towards a unified consensus linkage map of tetraploid cotton
    Jean Marc Lacape
    CIRAD, UMR DAP, Avenue Agropolis, 34398 Montpellier Cedex 5, France
    Theor Appl Genet 119:281-92. 2009
    ..The new RIL population will be further exploited for fiber property QTL mapping and eQTL mapping...
  55. ncbi Comparison of human genetic and sequence-based physical maps
    A Yu
    Center for Medical Genetics, Marshfield Medical Research Foundation, Wisconsin 54449, USA
    Nature 409:951-3. 2001
    ..Linkage disequilibrium was much more common and extended for greater distances in the deserts than in the jungles...
  56. ncbi Physical chromosome mapping of repetitive DNA sequences in Nile tilapia Oreochromis niloticus: evidences for a differential distribution of repetitive elements in the sex chromosomes
    Irani A Ferreira
    Departamento de Morfologia, Instituto de Biociencias, UNESP Universidade Estadual Paulista, 18618 000 Botucatu, SP, Brazil
    Micron 39:411-8. 2008
    ..The distribution of repetitive DNAs differed significantly between the p arm of X and Y chromosomes. These findings suggest that repetitive DNAs have had an important role in the differentiation of sex chromosomes...
  57. ncbi Random sheared fosmid library as a new genomic tool to accelerate complete finishing of rice (Oryza sativa spp. Nipponbare) genome sequence: sequencing of gap-specific fosmid clones uncovers new euchromatic portions of the genome
    Jetty S S Ammiraju
    Department of Plant Sciences and BIO5 Institute, Arizona Genomics Institute, The University of Arizona, Tucson, AZ 85721, USA
    Theor Appl Genet 111:1596-607. 2005
    ..Further sequencing of 12 of the gap-specific fosmid clones uncovered unique rice genome sequence that was not previously reported in the finished IRGSP sequence and emphasizes the need to complete finishing of the rice genome...
  58. ncbi Identification of a novel protein interacting with RPGR
    J P Boylan
    MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Hum Mol Genet 9:2085-93. 2000
    ..The function of RPGRIP is unknown; it shows no homology to proteins of known function, although it is predicted to form two coiled-coil domains at the N-terminus. RPGRIP is a strong candidate gene for causing human retinal degeneration...
  59. ncbi Fine mapping a QTL qCTB7 for cold tolerance at the booting stage on rice chromosome 7 using a near-isogenic line
    Lei Zhou
    Key Laboratory of Crop Genomics and Genetic Improvement, Ministry of Agriculture, and Beijing Key Laboratory of Crop Genetic Improvement, China Agricultural University, Beijing, 100193, China
    Theor Appl Genet 121:895-905. 2010
    ..This interval was present in BAC clone AP003804. We designated the QTL as qCTB7 (quantitative trait locus for cold tolerance at the booting stage on chromosome 7), and identified 12 putative candidate genes...
  60. pmc Bacterial artificial chromosome-based physical map of the rice genome constructed by restriction fingerprint analysis
    Q Tao
    Department of Soil and Crop Sciences and Crop Biotechnology Center, Texas A and M University, College Station, TX 77843-2123, USA
    Genetics 158:1711-24. 2001
    ..This study indicates that genome-wide BAC-based physical maps can be developed quickly and economically for a variety of plant and animal species by restriction fingerprint analysis via DNA sequencing gel-based electrophoresis...
  61. ncbi Strategies for the systematic sequencing of complex genomes
    E D Green
    Genome Technology Branch and NIH Intramural Sequencing Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Genet 2:573-83. 2001
    ..As well as providing data of fundamental biological significance, these landmark accomplishments have yielded important strategic insights that are guiding current and future genome-sequencing projects...
  62. pmc Chromosome sorting in tetraploid wheat and its potential for genome analysis
    Marie Kubaláková
    Laboratory of Molecular Cytogenetics and Cytometry, Institute of Experimental Botany, Olomouc, Czech Republic
    Genetics 170:823-9. 2005
    ..This study considerably expands the potential of flow cytogenetics for use in wheat genomics and opens the possibility of sequencing the genome of this important crop one chromosome arm at a time...
  63. pmc Chromosome isolation by flow sorting in Aegilops umbellulata and Ae. comosa and their allotetraploid hybrids Ae. biuncialis and Ae. geniculata
    Istvan Molnar
    Agricultural Research Institute of the Hungarian Academy of Sciences, Martonvasar, Hungary
    PLoS ONE 6:e27708. 2011
    ..The results obtained in this work provide new opportunities for dissecting genomes of wild relatives of wheat with the aim to assist in alien gene transfer and discovery of novel genes for wheat improvement...
  64. ncbi Genetics. Chicken genome--science nuggets to come soon
    Dave Burt
    Roslin Institute Edinburgh, Midlothian EH25 9PS, UK
    Science 300:1669. 2003
  65. pmc Contigs built with fingerprints, markers, and FPC V4.7
    C Soderlund
    Clemson University Genomic Institute, Clemson, South Carolina 29634 5808, USA
    Genome Res 10:1772-87. 2000
    ..This paper describes the new features in FPC, the scenario for building the maps of chromosomes 9, 10 and 13, and the results from the simulation...
  66. pmc Discrepancies between recombination frequencies and physical distances in Aspergillus nidulans: implications for gene identification
    Eduardo A Espeso
    Departamento de Microbiologia Molecular, Centro de Investigaciones Biologicas, CSIC, Madrid, Spain
    Genetics 171:835-8. 2005
    ..Recombination frequencies are greatly reduced near the centromeres on the right arms of chromosomes III and IV of Aspergillus nidulans...
  67. ncbi Extension, single-locus conversion and physical mapping of sex chromosome sequences identify the Z microchromosome and pseudo-autosomal region in a dragon lizard, Pogona vitticeps
    A E Quinn
    Wildlife Genetics Laboratory, Institute for Applied Ecology, University of Canberra, Australian Capital Territory 2601, Australia
    Heredity (Edinb) 104:410-7. 2010
    ..Further physical mapping and isolation of sex-specific bacterial artificial chromosome clones will provide insight into the evolution of sex determination and sex chromosomes in GSD and TSD dragon lizards...
  68. pmc BAC library resources for map-based cloning and physical map construction in barley (Hordeum vulgare L.)
    Daniela Schulte
    Leibniz Institute of Plant Genetics and Crop Plant Research, Corrensstr, 3, 06466 Gatersleben, Germany
    BMC Genomics 12:247. 2011
    ..To start such an endeavor, large insert genomic libraries, i.e. Bacterial Artificial Chromosome (BAC) libraries, which are unbiased and representing deep haploid genome coverage, need to be ready in place...
  69. pmc A physical map of the polytenized region (101EF-102F) of chromosome 4 in Drosophila melanogaster
    J Locke
    Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada
    Genetics 155:1175-83. 2000
    ..A minimal tiling set of the clones we have mapped will facilitate both the assembly of the DNA sequence of the chromosome and a functional analysis of its genes...
  70. ncbi Shotgun sequence assembly and recent segmental duplications within the human genome
    Xinwei She
    Department of Genome Sciences, University of Washington School of Medicine, 1705 NE Pacific Street, Seattle, Washington 98195, USA
    Nature 431:927-30. 2004
  71. ncbi Genetic and physical fine mapping of Scmv2, a potyvirus resistance gene in maize
    Christina Roenn Ingvardsen
    Department of Genetics and Biotechnology, Faculty of Agricultural Sciences, University of Aarhus, Forsøgsvej 1, 4200, Slagelse, Denmark
    Theor Appl Genet 120:1621-34. 2010
    ..Analysis of the public B73 BAC library as well as the syntenic rice region did not reveal any similarity to known resistance genes. However, four new candidate genes with a possible involvement in movement of virus were detected...
  72. pmc Uprobe: a genome-wide universal probe resource for comparative physical mapping in vertebrates
    Wendy A Kellner
    Emory University School of Medicine, Department of Human Genetics, Atlanta, Georgia 30322, USA
    Genome Res 15:166-73. 2005
    ..Future implementation of the universal probe design strategy will be used to create an expanded number of whole-genome probe sets that will encompass all vertebrate genomes...
  73. ncbi Bacterial artificial chromosome-based physical map of Gibberella zeae (Fusarium graminearum)
    Yueh Long Chang
    Institute of Agricultural Biotechnology, National Chiayi University, Chiayi 600, Taiwan
    Genome 50:954-62. 2007
    ..We also end-sequenced 17 BamHI BAC clones and identified 4 clones that spanned gaps in the genome sequence. Our new integrated map is highly reliable and useful for a variety of genomics studies...
  74. pmc Construction of a nurse shark (Ginglymostoma cirratum) bacterial artificial chromosome (BAC) library and a preliminary genome survey
    Meizhong Luo
    Arizona Genomics Institute, Department of Plant Sciences, University of Arizona, Tucson, AZ 85721, USA
    BMC Genomics 7:106. 2006
  75. ncbi Identification, fine mapping and characterisation of a dwarf mutant (bnaC.dwf) in Brassica napus
    Xinhua Zeng
    National Key Laboratory of Crop Genetic Improvement, National Center of Rapeseed Improvement in Wuhan, Huazhong Agricultural University, Wuhan, 430070, People s Republic of China
    Theor Appl Genet 122:421-8. 2011
    ..The molecular markers developed from these investigations will greatly accelerate the selection process for developing dwarf varieties in B. napus by Marker Assisted Selection and genetic engineering...
  76. ncbi The dog genome: survey sequencing and comparative analysis
    Ewen F Kirkness
    The Institute for Genomic Research, Rockville, MD 20850, USA
    Science 301:1898-903. 2003
    ..A variety of polymorphic elements are identified that will be valuable for mapping the genetic basis of diseases and traits in the dog...
  77. pmc Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence
    Susan E Celniker
    Berkeley Drosophila Genome Project, Department of Genome Sciences, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Genome Biol 3:RESEARCH0079. 2002
  78. ncbi STAIRS: a new genetic resource for functional genomic studies of Arabidopsis
    Rachil Koumproglou
    School of Biosciences, The University of Birmingham, Birmingham B15 2TT, UK
    Plant J 31:355-64. 2002
    ..We were able to locate flowering QTL at the top of chromosome 3 known to contain several potential candidate genes...
  79. pmc Genetic and bioinformatic analysis of 41C and the 2R heterochromatin of Drosophila melanogaster: a window on the heterochromatin-euchromatin junction
    Steven H Myster
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599 3280, USA
    Genetics 166:807-22. 2004
    ..This allowed us to assign two of the complementation groups to particular "computed/curated genes" (CGs), one of which is Nipped-A, which our evidence suggests encodes Drosophila Tra1/TRRAP...
  80. pmc National Science Foundation-sponsored workshop report. Draft plan for soybean genomics
    Gary Stacey
    National Center for Soybean Biotechnology, Department of Plant Microbiology and Pathology, University of Missouri, Columbia, Missouri 65203, USA
    Plant Physiol 135:59-70. 2004
    ..The development of additional markers, reverse genetics tools, and bioinformatics is also necessary. Successful implementation of these goals will require close coordination among various working groups...
  81. pmc A 4,103 marker integrated physical and comparative map of the horse genome
    T Raudsepp
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843, USA
    Cytogenet Genome Res 122:28-36. 2008
    ..It will also serve as a tool to identify genes governing health, disease and performance traits in horses and assist us in understanding the evolution of the equine genome in relation to other species...
  82. ncbi A 1.4-Mb high-resolution physical map and contig of chromosome segment 11p15.5 and genes in the LOH11A metastasis suppressor region
    G Bepler
    Thoracic Oncology Program, Department of Medicine and Department of Radiology, Durham, North Carolina, 27710, USA
    Genomics 55:164-75. 1999
    ..The malignant phenotype, in this case, results from a relative loss of function rather than a complete loss...
  83. ncbi Phytophthora genome sequences uncover evolutionary origins and mechanisms of pathogenesis
    Brett M Tyler
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Science 313:1261-6. 2006
  84. ncbi Analysis of the barley bract suppression gene Trd1
    Kelly Houston
    The James Hutton Institute, Invergowrie, Dundee, DD2 5DA, Scotland, UK
    Theor Appl Genet 125:33-45. 2012
    ..Together with genetic linkage data, we confirm the identity of Trd1 as the GATA transcription factor ortholog of rice Nl1 and maize Tsh1 genes...
  85. pmc Mapping of loci from Solanum lycopersicoides conferring resistance or susceptibility to Botrytis cinerea in tomato
    Joel Davis
    Department of Horticulture, Oregon State University, Corvallis, OR 97331, USA
    Theor Appl Genet 119:305-14. 2009
    ..Linkage of partial resistance to chromosome 9 could not be confirmed. The usefulness of these data for resistance breeding and for map-based cloning of foliar resistance to B. cinerea is discussed...
  86. ncbi Zebrafish genetic map with 2000 microsatellite markers
    N Shimoda
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Genomics 58:219-32. 1999
    ..2-cM average resolution. One centimorgan in zebrafish is about 0. 74 megabase, so, for many mutations, these markers are close enough to begin positional cloning by YAC walks...
  87. pmc Identification of a missense mutation in the bovine ABCG2 gene with a major effect on the QTL on chromosome 6 affecting milk yield and composition in Holstein cattle
    Miri Cohen-Zinder
    Institute of Animal Sciences, Agricultural Research Organization, Bet Dagan 50250, Israel
    Genome Res 15:936-44. 2005
    ..09% fat, and 0.08% protein (F-value = 394), with partial dominance towards the 581S homozygotes. We therefore propose that Y581S in ABCG2 is the causative site for this QTL...
  88. pmc Comparative physical mapping links conservation of microsynteny to chromosome structure and recombination in grasses
    John E Bowers
    Plant Genome Mapping Laboratory, University of Georgia, Athens, GA 30602, USA
    Proc Natl Acad Sci U S A 102:13206-11. 2005
    ..Bridging of 35 physical gaps in the rice sequence by sorghum BAC contigs illustrates reciprocal benefits of comparative approaches that extend at least across the cereals and perhaps beyond...
  89. ncbi An abundant placental transcript containing an IAP-LTR is allelic to mouse pregnancy-specific glycoprotein 23 (Psg23): cloning and genetic analysis
    Melanie Ball
    Department of Biochemistry, Biosciences Institute, University College Cork, College Road, Cork, Ireland
    Gene 325:103-13. 2004
    ..However, a larger study would be required to determine whether this allele is selectively advantageous to the developing embryo...
  90. ncbi High resolution genetic mapping and candidate gene identification at the xa5 locus for bacterial blight resistance in rice ( Oryza sativa L.)
    Matthew W Blair
    Department of Plant Breeding, 240 Emerson Hall, Cornell University, Ithaca, NY 14853 1901, USA
    Theor Appl Genet 107:62-73. 2003
    ..The mechanism by which these genes could provide recessive, race-specific resistance will be elucidated by map-based cloning of the xa5 gene...
  91. pmc Physical mapping of a large plant genome using global high-information-content-fingerprinting: the distal region of the wheat ancestor Aegilops tauschii chromosome 3DS
    Delphine Fleury
    Australian Centre for Plant Functional Genomics, University of Adelaide, PMB1, Glen Osmond SA 5064, Australia
    BMC Genomics 11:382. 2010
    ..aestivum since it is only slightly larger than the ancestor wheat D genome. Gene co-linearity between the grasses can be exploited by extrapolating from rice and Brachypodium distachyon to Ae. tauschii or barley, and then to wheat...
  92. ncbi High resolution genetic and physical mapping of the I-3 region of tomato chromosome 7 reveals almost continuous microsynteny with grape chromosome 12 but interspersed microsynteny with duplications on Arabidopsis chromosomes 1, 2 and 3
    G T T Lim
    Plant Cell Biology, Research School of Biological Sciences, The Australian National University, Canberra, ACT, 0200, Australia
    Theor Appl Genet 118:57-75. 2008
    ..An S-receptor-like kinase gene family present in the I-3 region of tomato chromosome 7 was found to be present in the microsyntenous region of grape chromosome 12 but was absent altogether from the A. thaliana genome...
  93. ncbi Genome structure in soybean revealed by a genomewide genetic map constructed from a single population
    Kiwoung Yang
    Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Cheongwon, Chungbuk 363 883, Republic of Korea
    Genomics 92:52-9. 2008
  94. ncbi Positional cloning identifies a novel cyclophilin as a candidate amplified oncogene in 1q21
    Leonardo A Meza-Zepeda
    Department of Tumour Biology, The Norwegian Radium Hospital, Montebello N 0310, Oslo, Norway
    Oncogene 21:2261-9. 2002
    ..Quite likely, the different genes may give selective advantages to different subsets of tumours...
  95. pmc Toward integration of comparative genetic, physical, diversity, and cytomolecular maps for grasses and grains, using the sorghum genome as a foundation
    X Draye
    Applied Genetic Technology Center, Departments of Crop and Soil Science, Botany, and Genetics, University of Georgia, Athens, GA 30602, USA
    Plant Physiol 125:1325-41. 2001
  96. ncbi Organization and evolution of olfactory receptor genes on human chromosome 11
    J A Buettner
    McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, 75235 8591, USA
    Genomics 53:56-68. 1998
    ..Phylogenetic analysis of the newly described OR genes suggests a mechanism for the generation of genetic diversity...
  97. pmc A BAC-based physical map of Brachypodium distachyon and its comparative analysis with rice and wheat
    Yong Q Gu
    1Genomics and Gene Discovery Research Unit, USDA ARS, Western Regional Research Center, 800 Buchanan Street, Albany, CA 94710, USA
    BMC Genomics 10:496. 2009
    ..A BAC-based physical map is one of them. A physical map will facilitate analysis of genome structure, comparative genomics, and assembly of the entire genome sequence...
  98. ncbi A complete mitochondrial genome of wheat (Triticum aestivum cv. Chinese Yumai), and fast evolving mitochondrial genes in higher plants
    Peng Cui
    The CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100029, People s Republic of China
    J Genet 88:299-307. 2009

Research Grants69

    Tara Matise; Fiscal Year: 2002
    ..Finally, she proposes to develop web-based servers to allow outside users to calculate map positions, based on multiple public radiation hybrid and linkage maps, of a marker or set of markers. ..
    David Severson; Fiscal Year: 2004
    ..abstract_text> ..
  3. High Resolution Genomic Analysis of Amplicon Structure
    Donna Albertson; Fiscal Year: 2007
    ..abstract_text> ..
  4. The Genetics of Female Reproductive Aging
    Tara Matise; Fiscal Year: 2008
    ..Finally, enhancing our understanding of reproductive senescence may facilitate improvements in technologies used for assisted reproduction. [unreadable] [unreadable] [unreadable]..
  5. The Rutgers Mapping Resources
    Tara C Matise; Fiscal Year: 2010
    ..Our proposal is submitted under PAR-05-057 "Continued development and maintenance of software," which aims to "support the continued development, maintenance, testing and evaluation of existing software." ..
    Peter White; Fiscal Year: 2002
    ..abstract_text> ..
  7. Multiple Functions of novel lysyl oxidase like proteins
    Katalin Csiszar; Fiscal Year: 2005
    ..abstract_text> ..
  8. Molecular Biology of Calcuim Channel Gamma Subunits
    Daniel Burgess; Fiscal Year: 2006
  9. CRCNS: Bayesian Analysis of Neural-Behavioral Interactions in Mental Illness
    Terran Lane; Fiscal Year: 2007
    ..This work will contribute toward improved diagnostics and therapies for schizophrenia, a disease that affects millions of people. ..
  10. Analysis of Human Telomeric Structural Variation
    Harold C Riethman; Fiscal Year: 2010
    Richard Mayeux; Fiscal Year: 2002
  12. Genomic Analysis of ER Negative Breast Cancer
    Donna Albertson; Fiscal Year: 2007
    ..In addition, these studies will determine which mouse models most closely resemble different subtypes of ER negative tumors at the molecular level, thereby enhancing their utility as preclinical models. ..
    PETER WARBURTON; Fiscal Year: 2007
    ..Investigation of human centromere structure, function and formation will greatly facilitate the construction of artificial human chromosomes for use as autonomous gene expression vectors. ..
  14. Genetic Association in Austism Disorder
    Kelly Frazer; Fiscal Year: 2004
    ..The identification of autism-associated genetic markers will allow the development of diagnostic tools to identify individuals with high risk of developing autism, and could ultimately lead to therapeutic breakthroughs. ..
    Harold Hoffman; Fiscal Year: 2002
    ..The achievement of these goals will result in identification of the gene responsible for familial cold urticaria which will ultimately lead to an understanding of the mechanism of the inflammatory response to a physical stimulus. ..
  16. Molecular Structure of Yeast Chromosome 1
    DAVID KABACK; Fiscal Year: 2005
    ..abstract_text> ..
  17. Cloning, Mapping and Sequencing Rodent Subtelomeric DNA
    Harold Riethman; Fiscal Year: 2005
    ..This basic approach to completing telomere mapping and sequencing has worked successfully for most human telomeres; we propose here to apply it to mouse and rat telomeres. ..
  18. Genomics resources and infrastructure for B. schlosseri
    Anthony De Tomaso; Fiscal Year: 2006
    ..In addition, these resources will be used to generate preliminary data for future funding. [unreadable] [unreadable]..
  19. High definition in vivo footprinting via single molecule sequencing
    Michael Dorschner; Fiscal Year: 2009
  20. Large-scale analysis of human genetic variation via Multiplex Barcode Sequencing
    Michael Dorschner; Fiscal Year: 2007
    ..Additionally, it will be applicable to both genomic DNA templates, and to cDNA enabling simultaneous sampling of genetic variation and gene expression. [unreadable] [unreadable] [unreadable]..
    Richard Mayeux; Fiscal Year: 2008
    ..The overall theme of this fourth renewal application is to identify reliable and valid antecedent biomarkers of AD and MCI and to extend these and other clinical parameters to the measurement of disease progression. ..
  22. Genome-wide analysis of genetic variation and expression.
    Vivian G Cheung; Fiscal Year: 2010
    ..Therefore, the molecular and analytical approaches developed here can be generalized and applied to the study of other quantitative traits in humans, including complex genetic diseases. ..
    Vivian Cheung; Fiscal Year: 2008
    ..It will also give insights into the pattern of human meiotic recombination, a key process that contributes to genetic diversity and to risk of non-disjunction. ..
  24. Human Kallikrein 4 (hK4): A New Prostatic Biomarker?
    Eleftherios Diamandis; Fiscal Year: 2003
    ..If successful, our research will contribute to the development of new prostatic biomarkers and possibly, to better diagnosis which may lead to better clinical outcomes and reduced healthcare costs. ..
  25. Alzheimer's Disease and Impaired APP Proteolysis
    Warren Ladiges; Fiscal Year: 2006
    ..unreadable] [unreadable]..
    Marina Myles Worsley; Fiscal Year: 2007
    ..abstract_text> ..
  27. E coli-based vectors for BAC delivery to mammalian cells
    PETER WARBURTON; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  28. Genetics of Schizophrenia in Oceanic Palau.
    Marina Myles Worsley; Fiscal Year: 2009
    ..Molecular and fine-mapping studies will identify risk loci. We believe this study is unique among studies of Scz genetics for its population, sample, research team and the novelty of hypotheses and approach. ..
    Lars Bertram; Fiscal Year: 2007
    ..While we have devised a strategy that integrates the best available methods to identify complex disease genes, we will routinely adjust our strategy to account for methodologic advances in this rapidly evolving field. ..
    Eleftherios Diamandis; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
    Malcolm Snead; Fiscal Year: 2007
  32. Gene Expression Phenotype in Autosomal Recessive Disease
    Vivian Cheung; Fiscal Year: 2007
    ..The approach can also be broadened to study the contribution of heterozygosity of recessive diseases to the complex genetic architecture of human diseases and traits. [unreadable] [unreadable]..
  33. Microarray-Based Scanning of the Mouse Genome
    Donna Albertson; Fiscal Year: 2008
    ..New approaches for hybridization and analysis will be developed to extend the dynamic range of the expression measurements so we can obtain data from mRNAs expressed at very low abundances. [unreadable] [unreadable] [unreadable]..
  34. Evolutionary Conserved Sequences in the Human Genome
    Kelly Frazer; Fiscal Year: 2005
    ..abstract_text> ..
    Timothy Behrens; Fiscal Year: 2005
    ..In addition, these experiments are likely to provide interesting new insights into the mechanisms that lead to autoimmunity, with potential therapeutic implications for patients with antibody-mediated autoimmune diseases such as SLE. ..
  36. The Aedes aegypti Genome Project
    David Severson; Fiscal Year: 2003
    ..The long range goal is to promote and foster collaboration between funding agencies to support an effort to sequence the entire A. aegypti genome. ..
  37. Molecular Genetics of Cervical Cancer Progression
    Murty Vundavalli; Fiscal Year: 2004
    ..The data generated from these studies will be used to determine the clinical significance and to develop a genetic prognostic model for identifying high-risk CINs that progress into invasive cancer. ..
  38. A 13q32 BAC Microarray for chromosome function analysis
    PETER WARBURTON; Fiscal Year: 2004
    ..The development of these types of high-density genomic microarrays will be a major step towards understanding the genomic organization and role of non-protein coding functional DNA elements in our cells. ..
    PIETER DIJKWEL; Fiscal Year: 2003
    ..abstract_text> ..
    Richard Mayeux; Fiscal Year: 2003
    ..The ultimate goal of this project is to chromosomally localize genes that may increase the risk of AD among the Caribbean Hispanic ethnic group. ..
  41. Amplicon Profiling by Array CGH
    Donna Albertson; Fiscal Year: 2004
    ..abstract_text> ..
    Warren Ladiges; Fiscal Year: 2004
  43. Large-Scale Low-Cost Genotyping for the Haplotype Map
    Kelly Frazer; Fiscal Year: 2004
    ..e. 2.25 million SNPs in 270 samples, plus 15 duplicates and 3 blanks) within one year, at the cost and quality specified by the HapMap Project, is well within our capacity. ..
    Boris Dunkov; Fiscal Year: 2004
    ..The organ specific expression will be studied in larvae and in female mosquitoes at various stages before and after blood feeding. ..
  45. Novel regulatory role of cryopyrin in inflammation
    Harold Hoffman; Fiscal Year: 2005
    ..abstract_text> ..
    PETER WARBURTON; Fiscal Year: 2002
    ..These studies propose to develop E. coli-based HAC vectors for human gene therapy that encompass novel approaches for gene delivery, accurate gene expression, and mitotic stability. ..
  47. Linkage Disequilibrium: mapping and positional cloning
    Newton Morton; Fiscal Year: 2006
    ..abstract_text> ..
    Joe Simpson; Fiscal Year: 2004
    ..These goals are vital to public health in contributing to the establishment of methods for production of safe, effective, quality herbal extracts for consumer use. ..
  49. Identifying the RP10 gene causing retinitis pigmentosa
    Stephen Daiger; Fiscal Year: 2004
    ..abstract_text> ..
    Robert Waterston; Fiscal Year: 2003
    ..elegans genome dictates the development, behavior, and other biology of this small but complex animal. In turn, the principles learned here should help to unlock the information stored in other animal genomes, including human. ..
  51. A New Biomarker for Ovarian Cancer Detection
    Eleftherios Diamandis; Fiscal Year: 2003
    ..In this grant proposal, we describe further studies, which will examine in greater detail, the ability of a test for the amount of this protein in blood to correctly diagnose the presence of ovarian cancer. ..
    SUSAN BROCKERHOFF; Fiscal Year: 2003
    ..As a first step towards this end, we will generate a database of retina-specific genes and map these genes. ..
  53. A Genome-wide Association Study for Early-Onset Myocardial Infarction
    David Altshuler; Fiscal Year: 2009
    ..Successfully identifying common gene variants and novel pathways underlying risk of Ml has the potential to transform understanding, treatment, and prevention of the leading cause of death in the U.S. (End of Abstract) ..
  54. Genomic and Functional Analysis of Oral Cancer Development
    Donna Albertson; Fiscal Year: 2009
    ..The most fundamental way to make progress toward improving diagnosis and treatment of oral cancer is to elucidate the specific genes and the interactions among genes that become abnormal as cancer develops. ..
    Vivian Cheung; Fiscal Year: 2002
    ..In the process of characterizing the clones, we will also get information that gives us insight into the concordance rate between RH map, genome sequence map and cytogenetic map. ..
    Warren Ladiges; Fiscal Year: 2001
    ..abstract_text> ..
  57. Admixture Mapping Development and Testing in AA SLE
    Michael Seldin; Fiscal Year: 2009
    ..abstract_text> ..
  58. Densoviruses as Transducing Vectors
    Jonathan Carlson; Fiscal Year: 2005
    ..This should provide valuable data for the eventual use of these viruses to control vector populations and vector-borne disease. ..
  59. MA Admixture Mapping Development & Application to NIDDM
    Michael Seldin; Fiscal Year: 2008
    ..Finally, the three strongest signals will be further investigated utilizing a dense set of SNPs in the putative susceptibility regions. [unreadable] [unreadable]..
  60. Genome Sequence Variation
    David Altshuler; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  61. Genomic variation, hapmap and disease
    David Altshuler; Fiscal Year: 2006
    ..The meeting will consist of invited presentations as well as talks and posters based on abstract submissions. [unreadable] [unreadable] [unreadable] [unreadable]..
  62. Design/Production of Haplotype Map of the Human Genome
    David Altshuler; Fiscal Year: 2008
    ..The haplotype map project will catalyze human genetic studies of unprecedented power and scope, promising increased insight into disease risk in the population, and ultimately, improved clinical care. ..
  63. Determinants of Bone Strength in Afro-Caribbean Families
    Joseph Zmuda; Fiscal Year: 2004
    ..The identification of these genes will likely yield fundamental insight on bone biology and may lead to the development of novel approaches to the diagnosis, treatment, and prevention of osteoporosis. ..
  64. Human Genome Sequence Variation & the Inherited Basis
    David Altshuler; Fiscal Year: 2004
    ..abstract_text> ..
  65. Anaplasma marginale genes determining tick transmission
    MICHAEL DARK; Fiscal Year: 2007
    ..The sponsors collaborate closely in research and have successfully mentored clinicians, graduate students, and post-doctoral fellows to research independence. ..
  66. Bone Strength Phenotypes in men: Genes and Environment
    Joseph Zmuda; Fiscal Year: 2008
    ..The improved understanding of the genetic regulation of bone strength that will emerge from the proposed project will yield fundamental insight into the basic mechanisms of male osteoporosis. ..
  67. Facilitation/Barriers in Non-Myeloablative Transplants
    Thai Cao; Fiscal Year: 2006
    ..abstract_text> ..