Genomes and Genes
physical chromosome mapping
Summary: Mapping of the linear order of genes on a chromosome with units indicating their distances by using methods other than genetic recombination. These methods include nucleotide sequencing, overlapping deletions in polytene chromosomes, and electron micrography of heteroduplex DNA. (From King & Stansfield, A Dictionary of Genetics, 5th ed)
Publications247 found, 100 shown here
- Genome analysis at different ploidy levels allows cloning of the powdery mildew resistance gene Pm3b from hexaploid wheatNabila Yahiaoui
Institute of Plant Biology, University of Zurich, Zollikerstrasse 107, 8008 Zurich, Switzerland
Plant J 37:528-38. 2004..These results demonstrate that the candidate gene, a member of the coiled-coil nucleotide binding site leucine-rich repeat (NBS-LRR) type of disease resistance genes, is the Pm3b gene...
- The sequence of the human genomeJ C Venter
Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA
Science 291:1304-51. 2001..Less than 1% of all SNPs resulted in variation in proteins, but the task of determining which SNPs have functional consequences remains an open challenge...
- Initial sequencing and comparative analysis of the mouse genomeRobert H Waterston
Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA
Nature 420:520-62. 2002....
- A physical map of the 1-gigabase bread wheat chromosome 3BEtienne Paux
Institut National de la Recherche Agronomique, Université Blaise Pascal INRA UBP, UMR 1095, Genetics Diversity and Ecophysiology of Cereals, Clermont Ferrand, France
Science 322:101-4. 2008..This physical map establishes a template for the remaining wheat chromosomes and demonstrates the feasibility of constructing physical maps in large, complex, polyploid genomes with a chromosome-based approach...
- The genome sequence of the malaria mosquito Anopheles gambiaeRobert A Holt
Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA
Science 298:129-49. 2002..An expressed sequence tag analysis of genes regulated by blood feeding provided insights into the physiological adaptations of a hematophagous insect...
- Microsatellite-based deletion bin system for the establishment of genetic-physical map relationships in wheat (Triticum aestivum L.)Pierre Sourdille
UMR INRA UBP Amélioration et Santé des Plantes, 234, avenue du Brézet, 63039 Clermont Ferrand, France
Funct Integr Genomics 4:12-25. 2004....
- Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotypeOlivier Jaillon
UMR 8030 Genoscope, CNRS and Université d Evry, 2 rue Gaston Cremieux, 91057 Evry Cedex, France
Nature 431:946-57. 2004....
- The physical and genetic framework of the maize B73 genomeFusheng Wei
Arizona Genomics Institute, Department of Plant Sciences, BIO5 Institute for Collaborative Research, University of Arizona, Tucson, Arizona, United States of America
PLoS Genet 5:e1000715. 2009..Finally we used all available physical, sequence, genetic, and optical data to generate a golden path (AGP) of chromosome-based pseudomolecules, herein referred to as the B73 Reference Genome Sequence version 1 (B73 RefGen_v1)...
- An overview of the apple genome through BAC end sequence analysisYuepeng Han
Department of Natural Resources and Environmental Sciences, University of Illinois, Urbana, IL 61801, USA
Plant Mol Biol 67:581-8. 2008..BAC end sequencing can be used to anchor a small proportion of the apple genome to the Populus and possibly to the Arabidopsis genomes...
- Distribution of microsatellites in the genome of Medicago truncatula: a resource of genetic markers that integrate genetic and physical mapsJeong Hwan Mun
Department of Plant Pathology, University of California, Davis 95616, USA
Genetics 172:2541-55. 2006..A total of 378 genetic markers could be integrated with sequenced BAC clones, anchoring 274 physical contigs that represent 174 Mbp of the genome and composing an estimated 70% of the euchromatic gene space...
- A whole-genome assembly of DrosophilaE W Myers
Celera Genomics, Inc, 45 West Gude Drive, Rockville, MD 20850, USA
Science 287:2196-204. 2000..99% without manual curation. As such, this initial reconstruction of the Drosophila sequence should be of substantial value to the scientific community...
- Physical mapping and BAC-end sequence analysis provide initial insights into the flax (Linum usitatissimum L.) genomeRaja Ragupathy
Cereal Research Centre, Agriculture and Agri Food Canada, Winnipeg, MB, Canada
BMC Genomics 12:217. 2011..We report here the first genome-wide physical map of flax and the generation and analysis of BAC-end sequences (BES) from 43,776 clones, providing initial insights into the genome...
- Whole-genome shotgun assembly and analysis of the genome of Fugu rubripesSamuel Aparicio
Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609
Science 297:1301-10. 2002..Conserved linkages between Fugu and human genes indicate the preservation of chromosomal segments from the common vertebrate ancestor, but with considerable scrambling of gene order...
- Development of chromosome-specific BAC resources for genomics of bread wheatJ Safar
Laboratory of Molecular Cytogenetics and Cytometry, Institute of Experimental Botany, Olomouc, Czech Republic
Cytogenet Genome Res 129:211-23. 2010..Each chromosome (arm)-specific library is composed of a manageable number of clones, and so represents a practical tool in the area of wheat genomics...
- Sequencing and assembly of low copy and genic regions of isolated Triticum aestivum chromosome arm 7DSPaul J Berkman
School of Land, Crop and Food Sciences and Australian Centre for Plant Functional Genomics, University of Queensland, Brisbane, QLD, Australia
Plant Biotechnol J 9:768-75. 2011..info. Our results suggest that the sequencing of isolated chromosome arms can provide valuable information of the gene content of wheat and is a step towards whole-genome sequencing and variation discovery in this important crop...
- A single molecule scaffold for the maize genomeShiguo Zhou
Laboratory for Molecular and Computational Genomics, Department of Chemistry, Laboratory of Genetics, UW Biotechnology Center, University of Wisconsin Madison, Madison, Wisconsin, United States of America
PLoS Genet 5:e1000711. 2009....
- Current status and the future of fluorescence in situ hybridization (FISH) in plant genome researchJiming Jiang
Department of Horticulture, University of Wisconsin, Madison, WI 53706, USA
Genome 49:1057-68. 2006..FISH coupled with immunoassays will be increasingly used to study features of chromatin at the cytological level that control expression and regulation of genes...
- A BAC-based physical map of the channel catfish genomePeng Xu
The Fish Molecular Genetics and Biotechnology Laboratory, Department of Fisheries and Allied Aquacultures, and Program of Cell and Molecular Biosciences, Aquatic Genomics Unit, Auburn University, Auburn, AL 36849, USA
Genomics 90:380-8. 2007..The presented physical map should greatly enhance genome research in the catfish, particularly aiding in the identification of genomic regions containing genes underlying important performance traits...
- A BAC-based physical map of Zhikong scallop (Chlamys farreri Jones et Preston)Xiaojun Zhang
Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China
PLoS ONE 6:e27612. 2011....
- The human transcriptome map reveals extremes in gene density, intron length, GC content, and repeat pattern for domains of highly and weakly expressed genesRogier Versteeg
Department of Human Genetics, Academic Medical Center, University of Amsterdam, 1100DE Amsterdam, The Netherlands
Genome Res 13:1998-2004. 2003..Ridges are therefore an integral part of a higher order structure in the genome related to transcriptional regulation...
- Gramene, a tool for grass genomicsDoreen H Ware
Cold Spring Harbor Laboratory, New York 11724, USA
Plant Physiol 130:1606-13. 2002..In this paper, we present a brief overview of the search tools available to the plant research community in Gramene...
- The S haplotype-specific F-box protein gene, SFB, is defective in self-compatible haplotypes of Prunus avium and P. mumeKoichiro Ushijima
Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
Plant J 39:573-86. 2004....
- Vrn-D4 is a vernalization gene located on the centromeric region of chromosome 5D in hexaploid wheatTetsuya Yoshida
Graduate School of Natural Science and Technology, Okayama University, 1 1 1, Tsushima Naka, Kita ku, Okayama 700 8530, Japan
Theor Appl Genet 120:543-52. 2010..The precise mapping and characterization of Vrn-D4 presented here represent a first step toward the positional cloning of this gene...
- A draft physical map of a D-genome cotton species (Gossypium raimondii)Lifeng Lin
Plant Genome Mapping Laboratory, University of Georgia, Athens, GA 30605, USA
BMC Genomics 11:395. 2010..Toward the long-term goal of characterizing the spectrum of diversity among cotton genomes, the worldwide cotton community has prioritized the D genome progenitor Gossypium raimondii for complete sequencing...
- Diversity arrays technology (DArT) for high-throughput profiling of the hexaploid wheat genomeMona Akbari
Triticarte P L, 1 Wilf Crane Crescent, Yarralumla, Canberra, ACT, 2600, Australia
Theor Appl Genet 113:1409-20. 2006....
- FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4M H Xie
Department of Molecular Biology, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
Cytokine 11:729-35. 1999..FGF-19 message is expressed in several tissues including fetal cartilage, skin, and retina, as well as adult gall bladder and is overexpressed in a colon adenocarcinoma cell line...
- Demarcating the gene-rich regions of the wheat genomeMustafa Erayman
Washington State University, Pullman, WA 99164, USA
Nucleic Acids Res 32:3546-65. 2004..More than 30% of the wheat genes are in recombination-poor regions thus are inaccessible to map-based cloning...
- Chromosome complement of the fungal plant pathogen Fusarium graminearum based on genetic and physical mapping and cytological observationsL R Gale
Cereal Disease Laboratory, U S Department of Agriculture, Agricultural Research Service, St Paul, Minnesota 55108, USA
Genetics 171:985-1001. 2005..A chromosome number of four was confirmed by cytological karyotyping. Further analysis of the genetic map data identified variation in recombination rate in different genomic regions that often spanned several hundred kilobases...
- A common inversion under selection in EuropeansHreinn Stefansson
deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Nat Genet 37:129-37. 2005..Here we show that the H2 lineage is undergoing positive selection in the Icelandic population, such that carrier females have more children and have higher recombination rates than noncarriers...
- Generation of a BAC-based physical map of the melon genomeVíctor M González
Molecular Genetics Department, Center for Research in Agricultural Genomics CRAG CSIC IRTA UAB, Jordi Girona, 18 26, 08034 Barcelona, Spain
BMC Genomics 11:339. 2010..A BAC-based melon physical map will be a useful tool to help assemble and refine the draft genome data that is being produced...
- The genome sequence of Caenorhabditis briggsae: a platform for comparative genomicsLincoln D Stein
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
PLoS Biol 1:E45. 2003..elegans genome. Based on similarity to C. briggsae, we found strong evidence for 1,300 new C. elegans genes. In addition, comparisons of the two genomes will help to understand the evolutionary forces that mold nematode genomes...
- The human transcriptome map: clustering of highly expressed genes in chromosomal domainsH Caron
Department of Human Genetics, Department of Pediatric Oncology, Emma Children's Hospital, Academic Medical Center, University of Amsterdam, Post Office Box 22700, 1100 DE Amsterdam, Netherlands
Science 291:1289-92. 2001..The map reveals a clustering of highly expressed genes to specific chromosomal regions. It provides a tool to search for genes that are overexpressed or silenced in cancer...
- Identical functional organization of nonpolytene and polytene chromosomes in Drosophila melanogasterTatyana Yu Vatolina
Institute of Molecular and Cellular Biology of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
PLoS ONE 6:e25960. 2011..As appeared, origin recognition complexes are located almost totally in the interbands of chromosomes...
- A diagnostic genetic test for the physical mapping of germline rearrangements in the susceptibility breast cancer genes BRCA1 and BRCA2Kevin Cheeseman
Genomic Vision, 80 84 rue des Meuniers, Bagneux, Paris, France
Hum Mutat 33:998-1009. 2012..We propose the developed genetic test as a valuable tool to screen large rearrangements in BRCA1 and BRCA2 to be combined in clinical settings with an assay capable of detecting small mutations...
- Dynamic intra-japonica subspecies variation and resource applicationHaiyan Lin
National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, China
Mol Plant 5:218-30. 2012..ZH11 BAC clones can be browsed, searched, and obtained at our website, http://GResource.hzau.edu.cn...
- Comparative physical maps derived from BAC end sequences of tilapia (Oreochromis niloticus)Lucile Soler
CIRAD PERSYST, Aquaculture Research Unit, TA B 20 A, Campus International de Baillarguet, 34398 Montpellier Cedex 5, France
BMC Genomics 11:636. 2010..Here we analyze BAC end-sequences to develop comparative physical maps, and estimate the number of genome rearrangements, between tilapia and other model fish species...
- Integration of physical and genetic maps in apple confirms whole-genome and segmental duplications in the apple genomeYuepeng Han
Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences, Moshan, Wuhan, 430074, PR China
J Exp Bot 62:5117-30. 2011..These findings demonstrated the presence of both genome-wide and segmental duplications in the apple genome and provided further insights into the complex polyploid ancestral origin of the apple...
- Cross-genome map based dissection of a nitrogen use efficiency ortho-metaQTL in bread wheat unravels concerted cereal genome evolutionUmar Masood Quraishi
INRA Université Blaise Pascal UMR 1095 GDEC, Domaine de Crouelle, 234 avenue du Brezet, 63100 Clermont Ferrand, France
Plant J 65:745-56. 2011..We propose an evolutionary model for the NUE locus in cereals from a common ancestral region, involving species specific shuffling events such as gene deletion, inversion, transposition and the invasion of repetitive elements...
- The Rpi-blb2 gene from Solanum bulbocastanum is an Mi-1 gene homolog conferring broad-spectrum late blight resistance in potatoEdwin A G van der Vossen
Plant Research International BV, PO Box 16, 6700 AA Wageningen, The Netherlands
Plant J 44:208-22. 2005..The contrasting evolutionary dynamics of the Rpi-blb2/Mi-1 loci in the two related genomes may reflect the opposite evolutionary potentials of the interacting pathogens...
- The stem rust resistance gene Rpg5 encodes a protein with nucleotide-binding-site, leucine-rich, and protein kinase domainsR Brueggeman
Department of Crop and Soil Science, Washington State University, Pullman, WA 99164, USA
Proc Natl Acad Sci U S A 105:14970-5. 2008..Involvement of actin depolymerizing factor genes in nonhost resistance has been documented, but discovery of their role in gene-for-gene interaction would be novel and needs to be further substantiated...
- Molecular dissection of Tomato leaf curl virus resistance in tomato line TY172 derived from Solanum peruvianumIlana Anbinder
Institute of Plant Sciences, Agricultural Research Organization, The Volcani Center, Bet Dagan, Israel
Theor Appl Genet 119:519-30. 2009..The minor QTLs, originated either from the resistant or susceptible parents, were mapped to chromosomes 1, 7, 9 and 11, and contributed 12% to the variation in symptom severity in addition to Ty-5...
- Alignment of genetic and physical maps of Gibberella zeaeJungkwan Lee
USDA ARS Plant Science and Entomology Research Unit, Throckmorton Plant Sciences Center, Kansas State University, Manhattan, KS 66506 5502, USA
Appl Environ Microbiol 74:2349-59. 2008..g., fertility and fitness) and genetic features (e.g., centromeres and recombination frequency) that do not have a known molecular signature in the genome...
- Exploiting plant somatic radiation hybrids for physical mapping of expressed sequence tagsJ Wardrop
Scottish Crop Research Institute, Invergowrie, Dundee, DD2 5DA, UK
Theor Appl Genet 108:343-8. 2004..Using panels of hybrids and ESTs, donor DNA retention and individual marker retention frequencies for the expressed portion of the barley genome in the hybrids were estimated...
- The barley stem rust-resistance gene Rpg1 is a novel disease-resistance gene with homology to receptor kinasesR Brueggeman
Department of Crop and Soil Sciences, Washington State University, Pullman, WA 99164 6420, USA
Proc Natl Acad Sci U S A 99:9328-33. 2002..identifying it as the Rpg1 gene. Rpg1 encodes a receptor kinase-like protein with two tandem protein kinase domains, a novel structure for a plant disease-resistance gene. Thus, it may represent a new class of plant resistance genes...
- An international reference consensus genetic map with 897 marker loci based on 11 mapping populations for tetraploid groundnut (Arachis hypogaea L.)Bhimana Gautami
Center of Excellence in Genomics, International Crops Research Institute for the Semi Arid Tropics ICRISAT, Patancheru, India
PLoS ONE 7:e41213. 2012....
- Genomic tools development for Aquilegia: construction of a BAC-based physical mapGuang Chen Fang
Department of Genetics and Biochemistry, Clemson University, SC 29634, USA
BMC Genomics 11:621. 2010..To gain insights into the genome structure and facilitate gene identification, comparative genomics and whole-genome shotgun sequencing assembly, BAC-based genomics resources are of crucial importance...
- Integration of genetic, physical, and cytogenetic maps for Brassica rapa chromosome A7Z Xiong
Division of Biological Sciences, Christopher S Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA
Cytogenet Genome Res 129:190-8. 2010..napus to demonstrate that this approach can facilitate studies of genome evolution by integrating the genetic, physical, and cytogenetic maps among closely related species of Brassica...
- A BAC/BIBAC-based physical map of chickpea, Cicer arietinum LXiaojun Zhang
Department of Soil and Crop Sciences, Texas A and M University, College Station, Texas 77843 2474, USA
BMC Genomics 11:501. 2010..The availability of a genome-wide physical map allows rapid fine mapping of QTL, development of high-density genome maps, and sequencing of the entire genome. However, no such a physical map has been developed in chickpea...
- Regulatory network construction in Arabidopsis by using genome-wide gene expression quantitative trait lociJoost J B Keurentjes
Laboratory of Genetics, Wageningen University, Arboretumlaan 4, NL 6703 BD Wageningen, The Netherlands
Proc Natl Acad Sci U S A 104:1708-13. 2007..Results that revealed clusters of coregulated genes and their most likely regulators were in agreement with published data, and unknown relationships could be predicted...
- Mapping and sequencing of structural variation from eight human genomesJeffrey M Kidd
Department of Genome Sciences and Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA
Nature 453:56-64. 2008..These data provide the first high-resolution sequence map of human structural variation--a standard for genotyping platforms and a prelude to future individual genome sequencing projects...
- Integration of the Aedes aegypti mosquito genetic linkage and physical mapsS E Brown
Department of Bioagricultural Sciences and Pest Management, College of Agricultural Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
Genetics 157:1299-305. 2001..Since the genetic linkage map is a RFLP cDNA-based map, these data also provide a minimal estimate for the size of the euchromatic regions. The implications of these findings on positional cloning in A. aegypti are discussed...
- Polytene chromosomal maps of 11 Drosophila species: the order of genomic scaffolds inferred from genetic and physical mapsStephen W Schaeffer
Department of Biology and Institute of Molecular Evolutionary Genetics, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
Genetics 179:1601-55. 2008..Despite the conservation of genes within homologous chromosome arms across species, the karyotypes of these species have changed through the fusion of chromosomal arms followed by subsequent rearrangement events...
- Integration of animal linkage and BAC contig maps using overgo hybridizationM N Romanov
Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Mich, USA
Cytogenet Genome Res 102:277-81. 2003..These data are publicly available, and they have been used in the assembly of a first generation BAC contig map of the chicken genome...
- A new interspecific, Gossypium hirsutum x G. barbadense, RIL population: towards a unified consensus linkage map of tetraploid cottonJean Marc Lacape
CIRAD, UMR DAP, Avenue Agropolis, 34398 Montpellier Cedex 5, France
Theor Appl Genet 119:281-92. 2009..The new RIL population will be further exploited for fiber property QTL mapping and eQTL mapping...
- Comparison of human genetic and sequence-based physical mapsA Yu
Center for Medical Genetics, Marshfield Medical Research Foundation, Wisconsin 54449, USA
Nature 409:951-3. 2001..Linkage disequilibrium was much more common and extended for greater distances in the deserts than in the jungles...
- Physical chromosome mapping of repetitive DNA sequences in Nile tilapia Oreochromis niloticus: evidences for a differential distribution of repetitive elements in the sex chromosomesIrani A Ferreira
Departamento de Morfologia, Instituto de Biociencias, UNESP Universidade Estadual Paulista, 18618 000 Botucatu, SP, Brazil
Micron 39:411-8. 2008..The distribution of repetitive DNAs differed significantly between the p arm of X and Y chromosomes. These findings suggest that repetitive DNAs have had an important role in the differentiation of sex chromosomes...
- Random sheared fosmid library as a new genomic tool to accelerate complete finishing of rice (Oryza sativa spp. Nipponbare) genome sequence: sequencing of gap-specific fosmid clones uncovers new euchromatic portions of the genomeJetty S S Ammiraju
Department of Plant Sciences and BIO5 Institute, Arizona Genomics Institute, The University of Arizona, Tucson, AZ 85721, USA
Theor Appl Genet 111:1596-607. 2005..Further sequencing of 12 of the gap-specific fosmid clones uncovered unique rice genome sequence that was not previously reported in the finished IRGSP sequence and emphasizes the need to complete finishing of the rice genome...
- Identification of a novel protein interacting with RPGRJ P Boylan
MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
Hum Mol Genet 9:2085-93. 2000..The function of RPGRIP is unknown; it shows no homology to proteins of known function, although it is predicted to form two coiled-coil domains at the N-terminus. RPGRIP is a strong candidate gene for causing human retinal degeneration...
- Fine mapping a QTL qCTB7 for cold tolerance at the booting stage on rice chromosome 7 using a near-isogenic lineLei Zhou
Key Laboratory of Crop Genomics and Genetic Improvement, Ministry of Agriculture, and Beijing Key Laboratory of Crop Genetic Improvement, China Agricultural University, Beijing, 100193, China
Theor Appl Genet 121:895-905. 2010..This interval was present in BAC clone AP003804. We designated the QTL as qCTB7 (quantitative trait locus for cold tolerance at the booting stage on chromosome 7), and identified 12 putative candidate genes...
- Bacterial artificial chromosome-based physical map of the rice genome constructed by restriction fingerprint analysisQ Tao
Department of Soil and Crop Sciences and Crop Biotechnology Center, Texas A and M University, College Station, TX 77843-2123, USA
Genetics 158:1711-24. 2001..This study indicates that genome-wide BAC-based physical maps can be developed quickly and economically for a variety of plant and animal species by restriction fingerprint analysis via DNA sequencing gel-based electrophoresis...
- Strategies for the systematic sequencing of complex genomesE D Green
Genome Technology Branch and NIH Intramural Sequencing Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Rev Genet 2:573-83. 2001..As well as providing data of fundamental biological significance, these landmark accomplishments have yielded important strategic insights that are guiding current and future genome-sequencing projects...
- Chromosome sorting in tetraploid wheat and its potential for genome analysisMarie Kubaláková
Laboratory of Molecular Cytogenetics and Cytometry, Institute of Experimental Botany, Olomouc, Czech Republic
Genetics 170:823-9. 2005..This study considerably expands the potential of flow cytogenetics for use in wheat genomics and opens the possibility of sequencing the genome of this important crop one chromosome arm at a time...
- Chromosome isolation by flow sorting in Aegilops umbellulata and Ae. comosa and their allotetraploid hybrids Ae. biuncialis and Ae. geniculataIstvan Molnar
Agricultural Research Institute of the Hungarian Academy of Sciences, Martonvasar, Hungary
PLoS ONE 6:e27708. 2011..The results obtained in this work provide new opportunities for dissecting genomes of wild relatives of wheat with the aim to assist in alien gene transfer and discovery of novel genes for wheat improvement...
- Genetics. Chicken genome--science nuggets to come soonDave Burt
Roslin Institute Edinburgh, Midlothian EH25 9PS, UK
Science 300:1669. 2003
- Contigs built with fingerprints, markers, and FPC V4.7C Soderlund
Clemson University Genomic Institute, Clemson, South Carolina 29634 5808, USA
Genome Res 10:1772-87. 2000..This paper describes the new features in FPC, the scenario for building the maps of chromosomes 9, 10 and 13, and the results from the simulation...
- Discrepancies between recombination frequencies and physical distances in Aspergillus nidulans: implications for gene identificationEduardo A Espeso
Departamento de Microbiologia Molecular, Centro de Investigaciones Biologicas, CSIC, Madrid, Spain
Genetics 171:835-8. 2005..Recombination frequencies are greatly reduced near the centromeres on the right arms of chromosomes III and IV of Aspergillus nidulans...
- Extension, single-locus conversion and physical mapping of sex chromosome sequences identify the Z microchromosome and pseudo-autosomal region in a dragon lizard, Pogona vitticepsA E Quinn
Wildlife Genetics Laboratory, Institute for Applied Ecology, University of Canberra, Australian Capital Territory 2601, Australia
Heredity (Edinb) 104:410-7. 2010..Further physical mapping and isolation of sex-specific bacterial artificial chromosome clones will provide insight into the evolution of sex determination and sex chromosomes in GSD and TSD dragon lizards...
- BAC library resources for map-based cloning and physical map construction in barley (Hordeum vulgare L.)Daniela Schulte
Leibniz Institute of Plant Genetics and Crop Plant Research, Corrensstr, 3, 06466 Gatersleben, Germany
BMC Genomics 12:247. 2011..To start such an endeavor, large insert genomic libraries, i.e. Bacterial Artificial Chromosome (BAC) libraries, which are unbiased and representing deep haploid genome coverage, need to be ready in place...
- A physical map of the polytenized region (101EF-102F) of chromosome 4 in Drosophila melanogasterJ Locke
Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada
Genetics 155:1175-83. 2000..A minimal tiling set of the clones we have mapped will facilitate both the assembly of the DNA sequence of the chromosome and a functional analysis of its genes...
- Shotgun sequence assembly and recent segmental duplications within the human genomeXinwei She
Department of Genome Sciences, University of Washington School of Medicine, 1705 NE Pacific Street, Seattle, Washington 98195, USA
Nature 431:927-30. 2004....
- Genetic and physical fine mapping of Scmv2, a potyvirus resistance gene in maizeChristina Roenn Ingvardsen
Department of Genetics and Biotechnology, Faculty of Agricultural Sciences, University of Aarhus, Forsøgsvej 1, 4200, Slagelse, Denmark
Theor Appl Genet 120:1621-34. 2010..Analysis of the public B73 BAC library as well as the syntenic rice region did not reveal any similarity to known resistance genes. However, four new candidate genes with a possible involvement in movement of virus were detected...
- Uprobe: a genome-wide universal probe resource for comparative physical mapping in vertebratesWendy A Kellner
Emory University School of Medicine, Department of Human Genetics, Atlanta, Georgia 30322, USA
Genome Res 15:166-73. 2005..Future implementation of the universal probe design strategy will be used to create an expanded number of whole-genome probe sets that will encompass all vertebrate genomes...
- Bacterial artificial chromosome-based physical map of Gibberella zeae (Fusarium graminearum)Yueh Long Chang
Institute of Agricultural Biotechnology, National Chiayi University, Chiayi 600, Taiwan
Genome 50:954-62. 2007..We also end-sequenced 17 BamHI BAC clones and identified 4 clones that spanned gaps in the genome sequence. Our new integrated map is highly reliable and useful for a variety of genomics studies...
- Construction of a nurse shark (Ginglymostoma cirratum) bacterial artificial chromosome (BAC) library and a preliminary genome surveyMeizhong Luo
Arizona Genomics Institute, Department of Plant Sciences, University of Arizona, Tucson, AZ 85721, USA
BMC Genomics 7:106. 2006....
- Identification, fine mapping and characterisation of a dwarf mutant (bnaC.dwf) in Brassica napusXinhua Zeng
National Key Laboratory of Crop Genetic Improvement, National Center of Rapeseed Improvement in Wuhan, Huazhong Agricultural University, Wuhan, 430070, People s Republic of China
Theor Appl Genet 122:421-8. 2011..The molecular markers developed from these investigations will greatly accelerate the selection process for developing dwarf varieties in B. napus by Marker Assisted Selection and genetic engineering...
- The dog genome: survey sequencing and comparative analysisEwen F Kirkness
The Institute for Genomic Research, Rockville, MD 20850, USA
Science 301:1898-903. 2003..A variety of polymorphic elements are identified that will be valuable for mapping the genetic basis of diseases and traits in the dog...
- Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequenceSusan E Celniker
Berkeley Drosophila Genome Project, Department of Genome Sciences, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Genome Biol 3:RESEARCH0079. 2002....
- STAIRS: a new genetic resource for functional genomic studies of ArabidopsisRachil Koumproglou
School of Biosciences, The University of Birmingham, Birmingham B15 2TT, UK
Plant J 31:355-64. 2002..We were able to locate flowering QTL at the top of chromosome 3 known to contain several potential candidate genes...
- Genetic and bioinformatic analysis of 41C and the 2R heterochromatin of Drosophila melanogaster: a window on the heterochromatin-euchromatin junctionSteven H Myster
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599 3280, USA
Genetics 166:807-22. 2004..This allowed us to assign two of the complementation groups to particular "computed/curated genes" (CGs), one of which is Nipped-A, which our evidence suggests encodes Drosophila Tra1/TRRAP...
- National Science Foundation-sponsored workshop report. Draft plan for soybean genomicsGary Stacey
National Center for Soybean Biotechnology, Department of Plant Microbiology and Pathology, University of Missouri, Columbia, Missouri 65203, USA
Plant Physiol 135:59-70. 2004..The development of additional markers, reverse genetics tools, and bioinformatics is also necessary. Successful implementation of these goals will require close coordination among various working groups...
- A 4,103 marker integrated physical and comparative map of the horse genomeT Raudsepp
Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843, USA
Cytogenet Genome Res 122:28-36. 2008..It will also serve as a tool to identify genes governing health, disease and performance traits in horses and assist us in understanding the evolution of the equine genome in relation to other species...
- A 1.4-Mb high-resolution physical map and contig of chromosome segment 11p15.5 and genes in the LOH11A metastasis suppressor regionG Bepler
Thoracic Oncology Program, Department of Medicine and Department of Radiology, Durham, North Carolina, 27710, USA
Genomics 55:164-75. 1999..The malignant phenotype, in this case, results from a relative loss of function rather than a complete loss...
- Phytophthora genome sequences uncover evolutionary origins and mechanisms of pathogenesisBrett M Tyler
Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
Science 313:1261-6. 2006....
- Analysis of the barley bract suppression gene Trd1Kelly Houston
The James Hutton Institute, Invergowrie, Dundee, DD2 5DA, Scotland, UK
Theor Appl Genet 125:33-45. 2012..Together with genetic linkage data, we confirm the identity of Trd1 as the GATA transcription factor ortholog of rice Nl1 and maize Tsh1 genes...
- Mapping of loci from Solanum lycopersicoides conferring resistance or susceptibility to Botrytis cinerea in tomatoJoel Davis
Department of Horticulture, Oregon State University, Corvallis, OR 97331, USA
Theor Appl Genet 119:305-14. 2009..Linkage of partial resistance to chromosome 9 could not be confirmed. The usefulness of these data for resistance breeding and for map-based cloning of foliar resistance to B. cinerea is discussed...
- Zebrafish genetic map with 2000 microsatellite markersN Shimoda
Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
Genomics 58:219-32. 1999..2-cM average resolution. One centimorgan in zebrafish is about 0. 74 megabase, so, for many mutations, these markers are close enough to begin positional cloning by YAC walks...
- Identification of a missense mutation in the bovine ABCG2 gene with a major effect on the QTL on chromosome 6 affecting milk yield and composition in Holstein cattleMiri Cohen-Zinder
Institute of Animal Sciences, Agricultural Research Organization, Bet Dagan 50250, Israel
Genome Res 15:936-44. 2005..09% fat, and 0.08% protein (F-value = 394), with partial dominance towards the 581S homozygotes. We therefore propose that Y581S in ABCG2 is the causative site for this QTL...
- Comparative physical mapping links conservation of microsynteny to chromosome structure and recombination in grassesJohn E Bowers
Plant Genome Mapping Laboratory, University of Georgia, Athens, GA 30602, USA
Proc Natl Acad Sci U S A 102:13206-11. 2005..Bridging of 35 physical gaps in the rice sequence by sorghum BAC contigs illustrates reciprocal benefits of comparative approaches that extend at least across the cereals and perhaps beyond...
- An abundant placental transcript containing an IAP-LTR is allelic to mouse pregnancy-specific glycoprotein 23 (Psg23): cloning and genetic analysisMelanie Ball
Department of Biochemistry, Biosciences Institute, University College Cork, College Road, Cork, Ireland
Gene 325:103-13. 2004..However, a larger study would be required to determine whether this allele is selectively advantageous to the developing embryo...
- High resolution genetic mapping and candidate gene identification at the xa5 locus for bacterial blight resistance in rice ( Oryza sativa L.)Matthew W Blair
Department of Plant Breeding, 240 Emerson Hall, Cornell University, Ithaca, NY 14853 1901, USA
Theor Appl Genet 107:62-73. 2003..The mechanism by which these genes could provide recessive, race-specific resistance will be elucidated by map-based cloning of the xa5 gene...
- Physical mapping of a large plant genome using global high-information-content-fingerprinting: the distal region of the wheat ancestor Aegilops tauschii chromosome 3DSDelphine Fleury
Australian Centre for Plant Functional Genomics, University of Adelaide, PMB1, Glen Osmond SA 5064, Australia
BMC Genomics 11:382. 2010..aestivum since it is only slightly larger than the ancestor wheat D genome. Gene co-linearity between the grasses can be exploited by extrapolating from rice and Brachypodium distachyon to Ae. tauschii or barley, and then to wheat...
- High resolution genetic and physical mapping of the I-3 region of tomato chromosome 7 reveals almost continuous microsynteny with grape chromosome 12 but interspersed microsynteny with duplications on Arabidopsis chromosomes 1, 2 and 3G T T Lim
Plant Cell Biology, Research School of Biological Sciences, The Australian National University, Canberra, ACT, 0200, Australia
Theor Appl Genet 118:57-75. 2008..An S-receptor-like kinase gene family present in the I-3 region of tomato chromosome 7 was found to be present in the microsyntenous region of grape chromosome 12 but was absent altogether from the A. thaliana genome...
- Genome structure in soybean revealed by a genomewide genetic map constructed from a single populationKiwoung Yang
Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Cheongwon, Chungbuk 363 883, Republic of Korea
Genomics 92:52-9. 2008....
- Positional cloning identifies a novel cyclophilin as a candidate amplified oncogene in 1q21Leonardo A Meza-Zepeda
Department of Tumour Biology, The Norwegian Radium Hospital, Montebello N 0310, Oslo, Norway
Oncogene 21:2261-9. 2002..Quite likely, the different genes may give selective advantages to different subsets of tumours...
- Toward integration of comparative genetic, physical, diversity, and cytomolecular maps for grasses and grains, using the sorghum genome as a foundationX Draye
Applied Genetic Technology Center, Departments of Crop and Soil Science, Botany, and Genetics, University of Georgia, Athens, GA 30602, USA
Plant Physiol 125:1325-41. 2001....
- Organization and evolution of olfactory receptor genes on human chromosome 11J A Buettner
McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, 75235 8591, USA
Genomics 53:56-68. 1998..Phylogenetic analysis of the newly described OR genes suggests a mechanism for the generation of genetic diversity...
- A BAC-based physical map of Brachypodium distachyon and its comparative analysis with rice and wheatYong Q Gu
1Genomics and Gene Discovery Research Unit, USDA ARS, Western Regional Research Center, 800 Buchanan Street, Albany, CA 94710, USA
BMC Genomics 10:496. 2009..A BAC-based physical map is one of them. A physical map will facilitate analysis of genome structure, comparative genomics, and assembly of the entire genome sequence...
- A complete mitochondrial genome of wheat (Triticum aestivum cv. Chinese Yumai), and fast evolving mitochondrial genes in higher plantsPeng Cui
The CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100029, People s Republic of China
J Genet 88:299-307. 2009....
- INTEGRATED MAPS USING RADIATION HYBRIDSTara Matise; Fiscal Year: 2002..Finally, she proposes to develop web-based servers to allow outside users to calculate map positions, based on multiple public radiation hybrid and linkage maps, of a marker or set of markers. ..
- RFLP MAPPING OF PLASMODIUM REFACTORY GENES IN MOSQUITOESDavid Severson; Fiscal Year: 2004..abstract_text> ..
- High Resolution Genomic Analysis of Amplicon StructureDonna Albertson; Fiscal Year: 2007..abstract_text> ..
- The Genetics of Female Reproductive AgingTara Matise; Fiscal Year: 2008..Finally, enhancing our understanding of reproductive senescence may facilitate improvements in technologies used for assisted reproduction. [unreadable] [unreadable] [unreadable]..
- The Rutgers Mapping ResourcesTara C Matise; Fiscal Year: 2010..Our proposal is submitted under PAR-05-057 "Continued development and maintenance of software," which aims to "support the continued development, maintenance, testing and evaluation of existing software." ..
- COMPREHENSIVE VIEWING OF THE HUMAN GENOMEPeter White; Fiscal Year: 2002..abstract_text> ..
- Multiple Functions of novel lysyl oxidase like proteinsKatalin Csiszar; Fiscal Year: 2005..abstract_text> ..
- Molecular Biology of Calcuim Channel Gamma SubunitsDaniel Burgess; Fiscal Year: 2006....
- CRCNS: Bayesian Analysis of Neural-Behavioral Interactions in Mental IllnessTerran Lane; Fiscal Year: 2007..This work will contribute toward improved diagnostics and therapies for schizophrenia, a disease that affects millions of people. ..
- Analysis of Human Telomeric Structural VariationHarold C Riethman; Fiscal Year: 2010....
- GENETIC EPIDEMIOLOGY OF AGING IN A MULTIETHNIC COMMUNITYRichard Mayeux; Fiscal Year: 2002....
- Genomic Analysis of ER Negative Breast CancerDonna Albertson; Fiscal Year: 2007..In addition, these studies will determine which mouse models most closely resemble different subtypes of ER negative tumors at the molecular level, thereby enhancing their utility as preclinical models. ..
- ANALYSIS OF HUMAN CHROMOSOME 13Q NEOCENTROMERE FORMATIONPETER WARBURTON; Fiscal Year: 2007..Investigation of human centromere structure, function and formation will greatly facilitate the construction of artificial human chromosomes for use as autonomous gene expression vectors. ..
- Genetic Association in Austism DisorderKelly Frazer; Fiscal Year: 2004..The identification of autism-associated genetic markers will allow the development of diagnostic tools to identify individuals with high risk of developing autism, and could ultimately lead to therapeutic breakthroughs. ..
- GENETIC AND MOLECULAR BASIS OF FAMILIAL COLD URTICARIAHarold Hoffman; Fiscal Year: 2002..The achievement of these goals will result in identification of the gene responsible for familial cold urticaria which will ultimately lead to an understanding of the mechanism of the inflammatory response to a physical stimulus. ..
- Molecular Structure of Yeast Chromosome 1DAVID KABACK; Fiscal Year: 2005..abstract_text> ..
- Cloning, Mapping and Sequencing Rodent Subtelomeric DNAHarold Riethman; Fiscal Year: 2005..This basic approach to completing telomere mapping and sequencing has worked successfully for most human telomeres; we propose here to apply it to mouse and rat telomeres. ..
- Genomics resources and infrastructure for B. schlosseriAnthony De Tomaso; Fiscal Year: 2006..In addition, these resources will be used to generate preliminary data for future funding. [unreadable] [unreadable]..
- High definition in vivo footprinting via single molecule sequencingMichael Dorschner; Fiscal Year: 2009....
- Large-scale analysis of human genetic variation via Multiplex Barcode SequencingMichael Dorschner; Fiscal Year: 2007..Additionally, it will be applicable to both genomic DNA templates, and to cDNA enabling simultaneous sampling of genetic variation and gene expression. [unreadable] [unreadable] [unreadable]..
- EPIDEMIOLOGY OF DEMENTIA IN AN URBAN COMMUNITYRichard Mayeux; Fiscal Year: 2008..The overall theme of this fourth renewal application is to identify reliable and valid antecedent biomarkers of AD and MCI and to extend these and other clinical parameters to the measurement of disease progression. ..
- Genome-wide analysis of genetic variation and expression.Vivian G Cheung; Fiscal Year: 2010..Therefore, the molecular and analytical approaches developed here can be generalized and applied to the study of other quantitative traits in humans, including complex genetic diseases. ..
- IBD MAPPING & PATTERN OF HUMAN MEIOTIC RECOMBINATIONVivian Cheung; Fiscal Year: 2008..It will also give insights into the pattern of human meiotic recombination, a key process that contributes to genetic diversity and to risk of non-disjunction. ..
- Human Kallikrein 4 (hK4): A New Prostatic Biomarker?Eleftherios Diamandis; Fiscal Year: 2003..If successful, our research will contribute to the development of new prostatic biomarkers and possibly, to better diagnosis which may lead to better clinical outcomes and reduced healthcare costs. ..
- Alzheimer's Disease and Impaired APP ProteolysisWarren Ladiges; Fiscal Year: 2006..unreadable] [unreadable]..
- FAMILY-GENETIC STUDY OF YOUTH AT RISK FOR SCHIZOPHRENIAMarina Myles Worsley; Fiscal Year: 2007..abstract_text> ..
- E coli-based vectors for BAC delivery to mammalian cellsPETER WARBURTON; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Genetics of Schizophrenia in Oceanic Palau.Marina Myles Worsley; Fiscal Year: 2009..Molecular and fine-mapping studies will identify risk loci. We believe this study is unique among studies of Scz genetics for its population, sample, research team and the novelty of hypotheses and approach. ..
- SEARCH FOR NOVEL EARLY-ONSET ALZHEIMER'S GENESLars Bertram; Fiscal Year: 2007..While we have devised a strategy that integrates the best available methods to identify complex disease genes, we will routinely adjust our strategy to account for methodologic advances in this rapidly evolving field. ..
- KALLIKREINS AS DIAGNOSTIC MARKERS OF OVARIAN CARCINOMAEleftherios Diamandis; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- CELL AND GENETIC APPROACHES TO ENAMEL BIOMIMETICSMalcolm Snead; Fiscal Year: 2007..unreadable]..
- Gene Expression Phenotype in Autosomal Recessive DiseaseVivian Cheung; Fiscal Year: 2007..The approach can also be broadened to study the contribution of heterozygosity of recessive diseases to the complex genetic architecture of human diseases and traits. [unreadable] [unreadable]..
- Microarray-Based Scanning of the Mouse GenomeDonna Albertson; Fiscal Year: 2008..New approaches for hybridization and analysis will be developed to extend the dynamic range of the expression measurements so we can obtain data from mRNAs expressed at very low abundances. [unreadable] [unreadable] [unreadable]..
- Evolutionary Conserved Sequences in the Human GenomeKelly Frazer; Fiscal Year: 2005..abstract_text> ..
- MECHANISMS THAT REGULATE B CELL TOLERANCETimothy Behrens; Fiscal Year: 2005..In addition, these experiments are likely to provide interesting new insights into the mechanisms that lead to autoimmunity, with potential therapeutic implications for patients with antibody-mediated autoimmune diseases such as SLE. ..
- The Aedes aegypti Genome ProjectDavid Severson; Fiscal Year: 2003..The long range goal is to promote and foster collaboration between funding agencies to support an effort to sequence the entire A. aegypti genome. ..
- Molecular Genetics of Cervical Cancer ProgressionMurty Vundavalli; Fiscal Year: 2004..The data generated from these studies will be used to determine the clinical significance and to develop a genetic prognostic model for identifying high-risk CINs that progress into invasive cancer. ..
- A 13q32 BAC Microarray for chromosome function analysisPETER WARBURTON; Fiscal Year: 2004..The development of these types of high-density genomic microarrays will be a major step towards understanding the genomic organization and role of non-protein coding functional DNA elements in our cells. ..
- EFFECTS OF CHROMATIN ARCHITECTURE ON ORIGIN ACTIVITYPIETER DIJKWEL; Fiscal Year: 2003..abstract_text> ..
- GENETIC EPIDEMIOLOGY OF ALZHEIMERS DISEASE IN HISPANICSRichard Mayeux; Fiscal Year: 2003..The ultimate goal of this project is to chromosomally localize genes that may increase the risk of AD among the Caribbean Hispanic ethnic group. ..
- Amplicon Profiling by Array CGHDonna Albertson; Fiscal Year: 2004..abstract_text> ..
- IMMUNOBIOLOGY OF AGING IN GENETICALLY ALTERED MICEWarren Ladiges; Fiscal Year: 2004....
- Large-Scale Low-Cost Genotyping for the Haplotype MapKelly Frazer; Fiscal Year: 2004..e. 2.25 million SNPs in 270 samples, plus 15 duplicates and 3 blanks) within one year, at the cost and quality specified by the HapMap Project, is well within our capacity. ..
- INSECT HEME OXYGENASEBoris Dunkov; Fiscal Year: 2004..The organ specific expression will be studied in larvae and in female mosquitoes at various stages before and after blood feeding. ..
- Novel regulatory role of cryopyrin in inflammationHarold Hoffman; Fiscal Year: 2005..abstract_text> ..
- E. COLI BASED VECTORS FOR GENE DELIVERY TO HUMAN CELLSPETER WARBURTON; Fiscal Year: 2002..These studies propose to develop E. coli-based HAC vectors for human gene therapy that encompass novel approaches for gene delivery, accurate gene expression, and mitotic stability. ..
- Linkage Disequilibrium: mapping and positional cloningNewton Morton; Fiscal Year: 2006..abstract_text> ..
- BAYLOR BIRCWH PROGRAMJoe Simpson; Fiscal Year: 2004..These goals are vital to public health in contributing to the establishment of methods for production of safe, effective, quality herbal extracts for consumer use. ..
- Identifying the RP10 gene causing retinitis pigmentosaStephen Daiger; Fiscal Year: 2004..abstract_text> ..
- ENHANCING THE VALUE OF THE C ELEGANS GENOME SEQUENCERobert Waterston; Fiscal Year: 2003..elegans genome dictates the development, behavior, and other biology of this small but complex animal. In turn, the principles learned here should help to unlock the information stored in other animal genomes, including human. ..
- A New Biomarker for Ovarian Cancer DetectionEleftherios Diamandis; Fiscal Year: 2003..In this grant proposal, we describe further studies, which will examine in greater detail, the ability of a test for the amount of this protein in blood to correctly diagnose the presence of ovarian cancer. ..
- PHOTORECEPTOR MUTATIONSSUSAN BROCKERHOFF; Fiscal Year: 2003..As a first step towards this end, we will generate a database of retina-specific genes and map these genes. ..
- A Genome-wide Association Study for Early-Onset Myocardial InfarctionDavid Altshuler; Fiscal Year: 2009..Successfully identifying common gene variants and novel pathways underlying risk of Ml has the potential to transform understanding, treatment, and prevention of the leading cause of death in the U.S. (End of Abstract) ..
- Genomic and Functional Analysis of Oral Cancer DevelopmentDonna Albertson; Fiscal Year: 2009..The most fundamental way to make progress toward improving diagnosis and treatment of oral cancer is to elucidate the specific genes and the interactions among genes that become abnormal as cancer develops. ..
- CHARACTERIZATION OF MAPPED HUMAN BAC CLONESVivian Cheung; Fiscal Year: 2002..In the process of characterizing the clones, we will also get information that gives us insight into the concordance rate between RH map, genome sequence map and cytogenetic map. ..
- TRANSGENIC ANIMAL MODEL DEVELOPMENT--PKR PROTEIN KINASEWarren Ladiges; Fiscal Year: 2001..abstract_text> ..
- Admixture Mapping Development and Testing in AA SLEMichael Seldin; Fiscal Year: 2009..abstract_text> ..
- Densoviruses as Transducing VectorsJonathan Carlson; Fiscal Year: 2005..This should provide valuable data for the eventual use of these viruses to control vector populations and vector-borne disease. ..
- MA Admixture Mapping Development & Application to NIDDMMichael Seldin; Fiscal Year: 2008..Finally, the three strongest signals will be further investigated utilizing a dense set of SNPs in the putative susceptibility regions. [unreadable] [unreadable]..
- Genome Sequence VariationDavid Altshuler; Fiscal Year: 2006..unreadable] [unreadable]..
- Genomic variation, hapmap and diseaseDavid Altshuler; Fiscal Year: 2006..The meeting will consist of invited presentations as well as talks and posters based on abstract submissions. [unreadable] [unreadable] [unreadable] [unreadable]..
- Design/Production of Haplotype Map of the Human GenomeDavid Altshuler; Fiscal Year: 2008..The haplotype map project will catalyze human genetic studies of unprecedented power and scope, promising increased insight into disease risk in the population, and ultimately, improved clinical care. ..
- Determinants of Bone Strength in Afro-Caribbean FamiliesJoseph Zmuda; Fiscal Year: 2004..The identification of these genes will likely yield fundamental insight on bone biology and may lead to the development of novel approaches to the diagnosis, treatment, and prevention of osteoporosis. ..
- Human Genome Sequence Variation & the Inherited BasisDavid Altshuler; Fiscal Year: 2004..abstract_text> ..
- Anaplasma marginale genes determining tick transmissionMICHAEL DARK; Fiscal Year: 2007..The sponsors collaborate closely in research and have successfully mentored clinicians, graduate students, and post-doctoral fellows to research independence. ..
- Bone Strength Phenotypes in men: Genes and EnvironmentJoseph Zmuda; Fiscal Year: 2008..The improved understanding of the genetic regulation of bone strength that will emerge from the proposed project will yield fundamental insight into the basic mechanisms of male osteoporosis. ..
- Facilitation/Barriers in Non-Myeloablative TransplantsThai Cao; Fiscal Year: 2006..abstract_text> ..