chromosome mapping

Summary

Summary: Any method used for determining the location of and relative distances between genes on a chromosome.

Top Publications

  1. ncbi Haploview: analysis and visualization of LD and haplotype maps
    J C Barrett
    Whitehead Institute for Biomedical Research Cambridge, MA 02142, USA
    Bioinformatics 21:263-5. 2005
  2. ncbi The B73 maize genome: complexity, diversity, and dynamics
    Patrick S Schnable
    Center for Plant Genomics, Iowa State University, Ames, IA 50011, USA
    Science 326:1112-5. 2009
  3. ncbi Initial sequencing and analysis of the human genome
    E S Lander
    Whitehead Institute for Biomedical Research, Center for Genome Research, Cambridge, Massachusetts 02142, USA
    Nature 409:860-921. 2001
  4. ncbi MapChart: software for the graphical presentation of linkage maps and QTLs
    R E Voorrips
    Plant Research International, P O Box 16, 6700 AA Wageningen, The Netherlands
    J Hered 93:77-8. 2002
  5. ncbi TASSEL: software for association mapping of complex traits in diverse samples
    Peter J Bradbury
    United States Department of Agriculture Agricultural Research Service, Institute for Genomic Diversity, Cornell University, Ithaca, New York, USA
    Bioinformatics 23:2633-5. 2007
  6. ncbi ACT: the Artemis Comparison Tool
    Tim J Carver
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
    Bioinformatics 21:3422-3. 2005
  7. pmc Rapid SNP discovery and genetic mapping using sequenced RAD markers
    Nathan A Baird
    Institute of Molecular Biology, University of Oregon, Eugene, Oregon, United States of America
    PLoS ONE 3:e3376. 2008
  8. pmc Identifying bacterial genes and endosymbiont DNA with Glimmer
    Arthur L Delcher
    Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA
    Bioinformatics 23:673-9. 2007
  9. ncbi R/qtl: QTL mapping in experimental crosses
    Karl W Broman
    Department of Biostatistics, Johns Hopkins University, 615 N Wolfe St, Baltimore, MD 21205, USA
    Bioinformatics 19:889-90. 2003
  10. ncbi The complete genome sequence of Escherichia coli K-12
    F R Blattner
    Laboratory of Genetics, University of Wisconsin Madison, 445 Henry Mall, Madison, WI 53706, USA
    Science 277:1453-62. 1997

Detail Information

Publications341 found, 100 shown here

  1. ncbi Haploview: analysis and visualization of LD and haplotype maps
    J C Barrett
    Whitehead Institute for Biomedical Research Cambridge, MA 02142, USA
    Bioinformatics 21:263-5. 2005
    ..Haploview is a software package that provides computation of linkage disequilibrium statistics and population haplotype patterns from primary genotype data in a visually appealing and interactive interface...
  2. ncbi The B73 maize genome: complexity, diversity, and dynamics
    Patrick S Schnable
    Center for Plant Genomics, Iowa State University, Ames, IA 50011, USA
    Science 326:1112-5. 2009
    ..These analyses inform and set the stage for further investigations to improve our understanding of the domestication and agricultural improvements of maize...
  3. ncbi Initial sequencing and analysis of the human genome
    E S Lander
    Whitehead Institute for Biomedical Research, Center for Genome Research, Cambridge, Massachusetts 02142, USA
    Nature 409:860-921. 2001
    ..We also present an initial analysis of the data, describing some of the insights that can be gleaned from the sequence...
  4. ncbi MapChart: software for the graphical presentation of linkage maps and QTLs
    R E Voorrips
    Plant Research International, P O Box 16, 6700 AA Wageningen, The Netherlands
    J Hered 93:77-8. 2002
  5. ncbi TASSEL: software for association mapping of complex traits in diverse samples
    Peter J Bradbury
    United States Department of Agriculture Agricultural Research Service, Institute for Genomic Diversity, Cornell University, Ithaca, New York, USA
    Bioinformatics 23:2633-5. 2007
    ..Other features include analyzing insertions/deletions, calculating diversity statistics, integration of phenotypic and genotypic data, imputing missing data and calculating principal components...
  6. ncbi ACT: the Artemis Comparison Tool
    Tim J Carver
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
    Bioinformatics 21:3422-3. 2005
    ..ACT is part of the Artemis distribution and is similarly open source, written in Java and can run on any Java enabled platform, including UNIX, Macintosh and Windows...
  7. pmc Rapid SNP discovery and genetic mapping using sequenced RAD markers
    Nathan A Baird
    Institute of Molecular Biology, University of Oregon, Eugene, Oregon, United States of America
    PLoS ONE 3:e3376. 2008
    ..Sequencing of RAD markers is an integrated platform for SNP discovery and genotyping. This approach should be widely applicable to genetic mapping in a variety of organisms...
  8. pmc Identifying bacterial genes and endosymbiont DNA with Glimmer
    Arthur L Delcher
    Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA
    Bioinformatics 23:673-9. 2007
    ..This module was developed in response to the discovery that eukaryotic genome sequencing projects sometimes inadvertently capture the DNA of intracellular bacteria living in the host...
  9. ncbi R/qtl: QTL mapping in experimental crosses
    Karl W Broman
    Department of Biostatistics, Johns Hopkins University, 615 N Wolfe St, Baltimore, MD 21205, USA
    Bioinformatics 19:889-90. 2003
    ....
  10. ncbi The complete genome sequence of Escherichia coli K-12
    F R Blattner
    Laboratory of Genetics, University of Wisconsin Madison, 445 Henry Mall, Madison, WI 53706, USA
    Science 277:1453-62. 1997
    ..The genome also contains insertion sequence (IS) elements, phage remnants, and many other patches of unusual composition indicating genome plasticity through horizontal transfer...
  11. ncbi Genome-wide genetic marker discovery and genotyping using next-generation sequencing
    John W Davey
    Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, King s Buildings, West Mains Road, Edinburgh, EH9 3JT, UK
    Nat Rev Genet 12:499-510. 2011
    ....
  12. pmc Circos: an information aesthetic for comparative genomics
    Martin Krzywinski
    Canada s Michael Smith Genome Sciences Center, Vancouver, British Columbia V5Z 4S6, Canada
    Genome Res 19:1639-45. 2009
    ....
  13. ncbi Mapping and quantifying mammalian transcriptomes by RNA-Seq
    Ali Mortazavi
    Division of Biology, MC 156 29, California Institute of Technology, Pasadena, California 91125, USA
    Nat Methods 5:621-8. 2008
    ..We observed 1.45 x 10(5) distinct splices, and alternative splices were prominent, with 3,500 different genes expressing one or more alternate internal splices...
  14. ncbi Whole-genome sequencing of multiple Arabidopsis thaliana populations
    Jun Cao
    Max Planck Institute for Developmental Biology, Tubingen, Germany
    Nat Genet 43:956-63. 2011
    ..thaliana diverged from its closest relative 10 million years ago with the spectrum observed in the laboratory. Recent species-wide selective sweeps are rare, and potentially deleterious mutations are more common in marginal populations...
  15. ncbi Automatic annotation of organellar genomes with DOGMA
    Stacia K Wyman
    Department of Computer Sciences, Institute of Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA
    Bioinformatics 20:3252-5. 2004
    ..Annotations are stored on our password-protected server to enable repeated sessions of working on the same genome. Finished annotations can be extracted for direct submission to GenBank...
  16. pmc Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
    Jeffrey C Barrett
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Nat Genet 41:703-7. 2009
    ..01; overall P < 5 × 10(-8)) and 4 additional regions provided nominal evidence of replication (P < 0.05). The many new candidate genes suggested by these results include IL10, IL19, IL20, GLIS3, CD69 and IL27...
  17. pmc RNA-Seq: a revolutionary tool for transcriptomics
    Zhong Wang
    Department of Molecular, Cellular and Developmental Biology, Yale University, 219 Prospect Street, New Haven, Connecticut 06520, USA
    Nat Rev Genet 10:57-63. 2009
    ..This article describes the RNA-Seq approach, the challenges associated with its application, and the advances made so far in characterizing several eukaryote transcriptomes...
  18. pmc Efficient control of population structure in model organism association mapping
    Hyun Min Kang
    Department of Computer Science, University of California, Los Angeles, California 90095 1596, USA
    Genetics 178:1709-23. 2008
    ..An R package implementation and webserver of our EMMA method are publicly available...
  19. ncbi MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations
    E S Lander
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142
    Genomics 1:174-81. 1987
    ..MAPMAKER has been applied to the construction of linkage maps in a number of organisms, including the human and several plants, and we outline the mapping strategies that have been used...
  20. ncbi GMAP: a genomic mapping and alignment program for mRNA and EST sequences
    Thomas D Wu
    Department of Bioinformatics Genentech, Inc, South San Francisco, CA 94080, USA
    Bioinformatics 21:1859-75. 2005
    ....
  21. pmc Personalized copy number and segmental duplication maps using next-generation sequencing
    Can Alkan
    Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington, USA
    Nat Genet 41:1061-7. 2009
    ..2 x 10(-16)). Our method can distinguish between different copies of highly identical genes, providing a more accurate assessment of gene content and insight into functional constraint without the limitations of array-based technology...
  22. ncbi Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits
    S Purcell
    Social, Genetics and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, De Crespigny Park, UK
    Bioinformatics 19:149-50. 2003
    ..A website for performing power calculations for the design of linkage and association genetic mapping studies of complex traits...
  23. ncbi The genetic architecture of maize flowering time
    Edward S Buckler
    U S Department of Agriculture USDA Agricultural Research Service USDA ARS, USA
    Science 325:714-8. 2009
    ..Thus, a simple additive model accurately predicts flowering time for maize, in contrast to the genetic architecture observed in the selfing plant species rice and Arabidopsis...
  24. ncbi The structure of haplotype blocks in the human genome
    Stacey B Gabriel
    Whitehead MIT Center for Genome Research, Cambridge, MA 02139, USA
    Science 296:2225-9. 2002
    ..Our results provide a foundation for the construction of a haplotype map of the human genome, facilitating comprehensive genetic association studies of human disease...
  25. ncbi Genic microsatellite markers in plants: features and applications
    Rajeev K Varshney
    Institute of Plant Genetics and Crop Plant Research IPK, Corrensstrasse 3, D 06466 Gatersleben, Germany
    Trends Biotechnol 23:48-55. 2005
    ..Applications and potential uses of EST-SSRs in plant genetics and breeding are discussed...
  26. pmc Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease
    Gosia Trynka
    Genetics Department, University Medical Center and University of Groningen, The Netherlands
    Nat Genet 43:1193-201. 2011
    ..Altogether, we define the complex genetic architecture of the risk regions of and refine the risk signals for celiac disease, providing the next step toward uncovering the causal mechanisms of the disease...
  27. pmc The genome of woodland strawberry (Fragaria vesca)
    Vladimir Shulaev
    Department of Biological Sciences, University of North Texas, Denton, Texas, USA
    Nat Genet 43:109-16. 2011
    ..New phylogenetic analysis of 154 protein-coding genes suggests that assignment of Populus to Malvidae, rather than Fabidae, is warranted...
  28. ncbi A first-generation haplotype map of maize
    Michael A Gore
    United States Department of Agriculture Agriculture Research Service USDA ARS, USA
    Science 326:1115-7. 2009
    ..This survey of genetic diversity provides a foundation for uniting breeding efforts across the world and for dissecting complex traits through genome-wide association studies...
  29. ncbi Genome-wide association study of leaf architecture in the maize nested association mapping population
    Feng Tian
    Institute for Genomic Diversity, Cornell University, Ithaca, New York, USA
    Nat Genet 43:159-62. 2011
    ..These results demonstrate that the use of GWAS with specially designed mapping populations is effective in uncovering the basis of key agronomic traits...
  30. ncbi Genome-wide high-resolution mapping and functional analysis of DNA methylation in arabidopsis
    Xiaoyu Zhang
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Cell 126:1189-201. 2006
    ....
  31. ncbi Mapping with RAD (restriction-site associated DNA) markers to rapidly identify QTL for stem rust resistance in Lolium perenne
    W F Pfender
    Department of Botany and Plant Pathology, USDA ARS Forage Seed and Cereal Research Unit, Oregon State University, 3450 SW Campus Way, Corvallis, OR 97331, USA
    Theor Appl Genet 122:1467-80. 2011
    ..RAD markers facilitated rapid construction of new genetic maps in this outcrossing species and will enable development of sequence-based markers linked to stem rust resistance in L. perenne...
  32. ncbi The genome of black cottonwood, Populus trichocarpa (Torr. & Gray)
    G A Tuskan
    Environmental Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA
    Science 313:1596-604. 2006
    ..Overrepresented exceptions in Populus include genes associated with lignocellulosic wall biosynthesis, meristem development, disease resistance, and metabolite transport...
  33. pmc Mapping short DNA sequencing reads and calling variants using mapping quality scores
    Heng Li
    The Wellcome Trust Sanger Institute, Hinxton CB10 1SA, United Kingdom
    Genome Res 18:1851-8. 2008
    ..Both read mapping and genotype calling are evaluated on simulated data and real data. MAQ is accurate, efficient, versatile, and user-friendly. It is freely available at http://maq.sourceforge.net...
  34. ncbi Next-generation DNA sequencing
    Jay Shendure
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195 5065, USA
    Nat Biotechnol 26:1135-45. 2008
    ....
  35. ncbi A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep
    Alex Clop
    Unit of Animal Genomics, Department of Animal Production, Faculty of Veterinary Medicine and Centre for Biomedical Integrative Genoproteomics, University of Liège B43, 20 Boulevard de Colonster, 4000 Liege, Belgium
    Nat Genet 38:813-8. 2006
    ..Analysis of SNP databases for humans and mice demonstrates that mutations creating or destroying putative miRNA target sites are abundant and might be important effectors of phenotypic variation...
  36. pmc A whole-genome assembly of the domestic cow, Bos taurus
    Aleksey V Zimin
    Institute for Physical Science and Technology, University of Maryland, College Park, Maryland 20742, USA
    Genome Biol 10:R42. 2009
    ..The genome of the domestic cow, Bos taurus, was sequenced using a mixture of hierarchical and whole-genome shotgun sequencing methods...
  37. pmc Diversity of human copy number variation and multicopy genes
    Peter H Sudmant
    Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA
    Science 330:641-6. 2010
    ..Our approach makes ~1000 genes accessible to genetic studies of disease association...
  38. ncbi Natural variation in Ghd7 is an important regulator of heading date and yield potential in rice
    Weiya Xue
    National Key Laboratory of Crop Genetic Improvement, National Centre of Plant Gene Research Wuhan, Huazhong Agricultural University, Wuhan 430070, China
    Nat Genet 40:761-7. 2008
    ..Natural mutants with reduced function enable rice to be cultivated in temperate and cooler regions. Thus, Ghd7 has played crucial roles for increasing productivity and adaptability of rice globally...
  39. pmc High-resolution mapping of expression-QTLs yields insight into human gene regulation
    Jean Baptiste Veyrieras
    Department of Human Genetics, The University of Chicago, Chicago, IL, USA
    PLoS Genet 4:e1000214. 2008
    ..Our results suggest an important role for mRNA stability in determining steady-state mRNA levels, and highlight the potential of eQTL mapping as a high-resolution tool for studying the determinants of gene regulation...
  40. pmc A large genome center's improvements to the Illumina sequencing system
    Michael A Quail
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK
    Nat Methods 5:1005-10. 2008
    ....
  41. pmc High-resolution mapping and characterization of open chromatin across the genome
    Alan P Boyle
    Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USA
    Cell 132:311-22. 2008
    ..In addition, and unexpectedly, our analyses have uncovered detailed features of nucleosome structure...
  42. pmc The genetics of Caenorhabditis elegans
    S Brenner
    Genetics 77:71-94. 1974
    ..Mutations in 77 of these alter the movement of the animal. Estimates of the induced mutation frequency of both the visible mutants and X chromosome lethals suggests that, just as in Drosophila, the genetic units in C. elegans are large...
  43. pmc Genome sequence, comparative analysis, and population genetics of the domestic horse
    C M Wade
    Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA
    Science 326:865-7. 2009
    ..Linkage disequilibrium, showing the influences of early domestication of large herds of female horses, is intermediate in length between dog and human, and there is long-range haplotype sharing among breeds...
  44. pmc Combinatorial patterns of histone acetylations and methylations in the human genome
    Zhibin Wang
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 40:897-903. 2008
    ..Our data suggest that these histone modifications may act cooperatively to prepare chromatin for transcriptional activation...
  45. pmc MEGA: a biologist-centric software for evolutionary analysis of DNA and protein sequences
    Sudhir Kumar
    Biodesign Institute, A240, Arizona State University, Tempe, AZ 85287 5301, USA
    Brief Bioinform 9:299-306. 2008
    ..We also discuss how MEGA might evolve in the future to assist researchers in their growing need to analyze large data set using new computational methods...
  46. ncbi The protein kinase complement of the human genome
    G Manning
    SUGEN Inc, 230 East Grand Avenue, South San Francisco, CA 94080, USA
    Science 298:1912-34. 2002
    ..We also identified 106 protein kinase pseudogenes. Chromosomal mapping revealed several small clusters of kinase genes and revealed that 244 kinases map to disease loci or cancer amplicons...
  47. pmc The genome of the Western clawed frog Xenopus tropicalis
    Uffe Hellsten
    Department of Energy Joint Genome Institute, Walnut Creek, CA 94598, USA
    Science 328:633-6. 2010
    ..The genome exhibits substantial shared synteny with human and chicken over major parts of large chromosomes, broken by lineage-specific chromosome fusions and fissions, mainly in the mammalian lineage...
  48. ncbi The genome sequence of Schizosaccharomyces pombe
    V Wood
    The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Nature 415:871-80. 2002
    ....
  49. pmc Promise and pitfalls of the Immunochip
    Adrian Cortes
    University of Queensland Diamantina Institute, Brisbane, Queensland, Australia
    Arthritis Res Ther 13:101. 2011
    ..This chip provides a powerful tool for immunogenetics gene mapping...
  50. ncbi Genome-wide association study of quantitative resistance to southern leaf blight in the maize nested association mapping population
    Kristen L Kump
    Department of Crop Science, North Carolina State University, Raleigh, North Carolina, USA
    Nat Genet 43:163-8. 2011
    ..Limited linkage disequilibrium was observed around some SNPs associated with SLB resistance, indicating that the maize NAM population enables high-resolution mapping of some genome regions...
  51. ncbi Genome-wide analysis of Arabidopsis thaliana DNA methylation uncovers an interdependence between methylation and transcription
    Daniel Zilberman
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Nat Genet 39:61-9. 2007
    ..Our results indicate that genic transcription and DNA methylation are closely interwoven processes...
  52. ncbi The genetics of quantitative traits: challenges and prospects
    Trudy F C Mackay
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Nat Rev Genet 10:565-77. 2009
    ..This systems genetics approach enables us to understand the biology inside the 'black box' that lies between genotype and phenotype in terms of causal networks of interacting genes...
  53. pmc Subspecific origin and haplotype diversity in the laboratory mouse
    Hyuna Yang
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Nat Genet 43:648-55. 2011
    ..The subspecific origin, haplotype diversity and identity by descent maps can be visualized using the Mouse Phylogeny Viewer (see URLs)...
  54. ncbi Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome
    Michael Weber
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Nat Genet 39:457-66. 2007
    ..Moreover, we observe that inactive unmethylated CpG island promoters show elevated levels of dimethylation of Lys4 of histone H3, suggesting that this chromatin mark may protect DNA from methylation...
  55. ncbi Copy number variation: new insights in genome diversity
    Jennifer L Freeman
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Genome Res 16:949-61. 2006
    ..Current efforts are directed toward a more comprehensive cataloging and characterization of CNVs that will provide the basis for determining how genomic diversity impacts biological function, evolution, and common human diseases...
  56. pmc High-throughput genotyping by whole-genome resequencing
    Xuehui Huang
    National Center for Gene Research and Institute of Plant Physiology and Ecology, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200233, China
    Genome Res 19:1068-76. 2009
    ....
  57. ncbi Genetic properties of the maize nested association mapping population
    Michael D McMullen
    United States Department of Agriculture Agriculture Research Service USDA ARS, USA
    Science 325:737-40. 2009
    ..This implies that pericentromeric regions may contribute disproportionally to heterosis...
  58. pmc Linkage mapping and comparative genomics using next-generation RAD sequencing of a non-model organism
    Simon W Baxter
    Department of Zoology, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 6:e19315. 2011
    ..mori chromosomes shows for the first time, genetic synteny appears common beyond the Macrolepidoptera. RAD sequencing is a powerful system capable of rapidly generating chromosome specific data for non-model organisms...
  59. pmc Identification of several small main-effect QTLs and a large number of epistatic QTLs for drought tolerance related traits in groundnut (Arachis hypogaea L.)
    K Ravi
    International Crops Research Institute for the Semi Arid Tropics, Patancheru, India
    Theor Appl Genet 122:1119-32. 2011
    ..This study suggests deployment of modern approaches like marker-assisted recurrent selection or genomic selection instead of marker-assisted backcrossing approach for breeding for drought tolerance in groundnut...
  60. ncbi Variants modulating the expression of a chromosome domain encompassing PLAG1 influence bovine stature
    Latifa Karim
    Unit of Animal Genomics, Interdisciplinary Institute of Applied Genomics GIGA R and Faculty of Veterinary Medicine, University of Liège B34, Liege, Belgium
    Nat Genet 43:405-13. 2011
    ..By performing expression QTL analyses, we identified a splice site variant in CHCHD7 and exploited this naturally occurring null allele to exclude CHCHD7 as single causative gene...
  61. pmc Positional cloning of the wheat vernalization gene VRN1
    L Yan
    Department of Agronomy and Range Science, University of California, Davis 95616, USA
    Proc Natl Acad Sci U S A 100:6263-8. 2003
    ..A mutation in the promoter region of AP1 would result in the lack of recognition of the repressor and in a dominant spring growth habit...
  62. ncbi OrganellarGenomeDRAW (OGDRAW): a tool for the easy generation of high-quality custom graphical maps of plastid and mitochondrial genomes
    Marc Lohse
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476 Potsdam Golm, Germany
    Curr Genet 52:267-74. 2007
    ..The design of the program core as a Perl module with an object-oriented interface allows easy integration into custom scripts...
  63. pmc Dissection of genetically complex traits with extremely large pools of yeast segregants
    Ian M Ehrenreich
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08540, USA
    Nature 464:1039-42. 2010
    ..Our method should have broad applications in yeast and can be extended to other organisms...
  64. pmc Transposable elements and the evolution of regulatory networks
    CEDRIC FESCHOTTE
    Department of Biology, Life Science Building, Box 19498, University of Texas, Arlington, Texas 76019, USA
    Nat Rev Genet 9:397-405. 2008
    ..Here I revisit and expand earlier models and propose that genomic repeats, and in particular transposable elements, have been a rich source of material for the assembly and tinkering of eukaryotic gene regulatory systems...
  65. pmc Sequencing of natural strains of Arabidopsis thaliana with short reads
    Stephan Ossowski
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    Genome Res 18:2024-33. 2008
    ..Our pipeline for aligning reads and predicting SNPs and indels, SHORE, is available for download at http://1001genomes.org...
  66. ncbi Single nucleotide polymorphism (SNP) discovery in the polyploid Brassica napus using Solexa transcriptome sequencing
    Martin Trick
    John Innes Centre, Norwich Research Park, Colney, Norwich NR4 7UH, UK
    Plant Biotechnol J 7:334-46. 2009
    ..For a specimen region of the genome analysed in detail, segregation of alleles largely, although not entirely, followed the pattern expected for genomic markers...
  67. pmc Construction and application for QTL analysis of a Restriction Site Associated DNA (RAD) linkage map in barley
    Yada Chutimanitsakun
    Crop and Soil Science Department, Oregon State University, Corvallis, Oregon, USA
    BMC Genomics 12:4. 2011
    ....
  68. pmc Prdm9 controls activation of mammalian recombination hotspots
    Emil D Parvanov
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Science 327:835. 2010
    ..The identification of Prdm9 as a protein regulating mammalian recombination hotspots initiates molecular studies of this important biological control system...
  69. ncbi Cytokinin oxidase regulates rice grain production
    Motoyuki Ashikari
    Bioscience and Biotechnology Center, Nagoya University, Nagoya 464 8601, Japan
    Science 309:741-5. 2005
    ..QTL pyramiding to combine loci for grain number and plant height in the same genetic background generated lines exhibiting both beneficial traits. These results provide a strategy for tailormade crop improvement...
  70. pmc A hidden markov model combining linkage and linkage disequilibrium information for haplotype reconstruction and quantitative trait locus fine mapping
    Tom Druet
    Unit of Animal Genomics, GIGA Research and Department of Animal Production, Faculty of Veterinary Medicine, University of Liege, Belgium
    Genetics 184:789-98. 2010
    ..We show that these cluster states can directly be used to fine map QTL. The method is computationally effective at handling large data sets based on high-density SNP panels...
  71. ncbi The sequence of the human genome
    J C Venter
    Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA
    Science 291:1304-51. 2001
    ..Less than 1% of all SNPs resulted in variation in proteins, but the task of determining which SNPs have functional consequences remains an open challenge...
  72. pmc The landscape of recombination in African Americans
    Anjali G Hinch
    Wellcome Trust Centre for Human Genetics, Oxford University, Roosevelt Drive, Oxford OX3 7BN, UK
    Nature 476:170-5. 2011
    ..Sites of this motif are predicted to be risk loci for disease-causing genomic rearrangements in individuals carrying these alleles. More generally, this map provides a resource for research in human genetic variation and evolution...
  73. pmc Unraveling ancient hexaploidy through multiply-aligned angiosperm gene maps
    Haibao Tang
    Plant Genome Mapping Laboratory, University of Georgia, Athens, Georgia 30602, USA
    Genome Res 18:1944-54. 2008
    ..Comparative analysis of inferred homologous genes derived from this model shows patterns of preferential gene retention or loss after polyploidy and reveals large variability of nucleotide substitution rates among plant nuclear genomes...
  74. pmc Amplification-free Illumina sequencing-library preparation facilitates improved mapping and assembly of (G+C)-biased genomes
    Iwanka Kozarewa
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Nat Methods 6:291-5. 2009
    ..We illustrate this by generating and analyzing DNA sequences from extremely (G+C)-poor (Plasmodium falciparum), (G+C)-neutral (Escherichia coli) and (G+C)-rich (Bordetella pertussis) genomes...
  75. ncbi CEGMA: a pipeline to accurately annotate core genes in eukaryotic genomes
    Genis Parra
    UC Davis Genome Center, University of California Davis, Davis, CA 95616, USA
    Bioinformatics 23:1061-7. 2007
    ..Unfortunately, many new genome projects lack comprehensive experimental data to derive a reliable initial set of genes...
  76. pmc Global variation in copy number in the human genome
    Richard Redon
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nature 444:444-54. 2006
    ..The data obtained delineate linkage disequilibrium patterns for many CNVs, and reveal marked variation in copy number among populations. We also demonstrate the utility of this resource for genetic disease studies...
  77. pmc Revealing the architecture of gene regulation: the promise of eQTL studies
    Yoav Gilad
    Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Trends Genet 24:408-15. 2008
    ....
  78. pmc Genome-wide mapping and assembly of structural variant breakpoints in the mouse genome
    Aaron R Quinlan
    Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Genome Res 20:623-35. 2010
    ..This result suggests that the genetic instability of such regions is often the cause rather than the consequence of duplicated genomic architecture...
  79. pmc Genomewide rapid association using mixed model and regression: a fast and simple method for genomewide pedigree-based quantitative trait loci association analysis
    Yurii S Aulchenko
    Department of Epidemiology and Biostatistics, Erasmus MC, 3000 CA Rotterdam, The Netherlands
    Genetics 177:577-85. 2007
    ..However, there is little or no difference in empirical power of MG and the proposed method. In any scenario, GRAMMAR is much faster than MG and enables rapid analysis of hundreds of thousands of markers...
  80. ncbi Efficient mapping of mendelian traits in dogs through genome-wide association
    Elinor K Karlsson
    Broad Institute of Harvard and Massachusetts Institute of Technology MIT, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Genet 39:1321-8. 2007
    ....
  81. ncbi Draft genome sequence of pigeonpea (Cajanus cajan), an orphan legume crop of resource-poor farmers
    Rajeev K Varshney
    International Crops Research Institute for the Semi Arid Tropics ICRISAT, Patancheru, India
    Nat Biotechnol 30:83-9. 2012
    ....
  82. ncbi Mapping genes for complex traits in domestic animals and their use in breeding programmes
    Michael E Goddard
    Department of Agriculture and Food Systems, University of Melbourne, Royal Parade, Parkville 3010, Australia
    Nat Rev Genet 10:381-91. 2009
    ..This approach is expected to double the rate of genetic improvement per year in many livestock systems...
  83. pmc Structure of linkage disequilibrium and phenotypic associations in the maize genome
    D L Remington
    Department of Genetics, North Carolina State University, Raleigh, NC 27695 7614, USA
    Proc Natl Acad Sci U S A 98:11479-84. 2001
    ..Provided the effects of population structure are effectively controlled, this research suggests that association studies show great promise for identifying the genetic basis of important traits in maize with very high resolution...
  84. pmc Systems genetics of complex traits in Drosophila melanogaster
    Julien F Ayroles
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Nat Genet 41:299-307. 2009
    ..Overlapping transcripts in modules associated with different traits provide insight into the molecular basis of pleiotropy between complex traits...
  85. pmc Linkage and association mapping of Arabidopsis thaliana flowering time in nature
    Benjamin Brachi
    Laboratoire Génétique et Evolution des Populations Végétales, Unité Mixte de Recherche CNRS 8016, Université des Sciences et Technologies de Lille 1, Villeneuve d Ascq, France
    PLoS Genet 6:e1000940. 2010
    ..Instead, we found a prevalence of genes involved in the regulation of the plant circadian clock. Furthermore, we identified new genomic regions lacking obvious candidate genes...
  86. pmc Association mapping of kernel size and milling quality in wheat (Triticum aestivum L.) cultivars
    Flavio Breseghello
    Department of Plant Breeding and Genetics, Cornell University, Ithaca, New York 14853, USA
    Genetics 172:1165-77. 2006
    ..Our results demonstrated that association mapping could complement and enhance previous QTL information for marker-assisted selection...
  87. ncbi Drought stress and tropical maize: QTL-by-environment interactions and stability of QTLs across environments for yield components and secondary traits
    Rainer Messmer
    ETH Zurich, Institute of Plant Sciences, 8092 Zurich, Switzerland
    Theor Appl Genet 119:913-30. 2009
    ..Those regions are clear targets for future marker-assisted breeding, and our results confirm that the best approach to breeding for drought tolerance includes selection under water stress...
  88. pmc High-throughput SNP discovery through deep resequencing of a reduced representation library to anchor and orient scaffolds in the soybean whole genome sequence
    David L Hyten
    Soybean Genomics and Improvement Laboratory, US Department of Agriculture, Agricultural Research Service, Beltsville, MD 20705, USA
    BMC Genomics 11:38. 2010
    ....
  89. ncbi 'Green revolution' genes encode mutant gibberellin response modulators
    J Peng
    John Innes Centre, Norwich Research Park, UK
    Nature 400:256-61. 1999
    ..Transgenic rice plants containing a mutant GAI allele give reduced responses to gibberellin and are dwarfed, indicating that mutant GAI orthologues could be used to increase yield in a wide range of crop species...
  90. pmc A high-density SNP-based linkage map of the chicken genome reveals sequence features correlated with recombination rate
    Martien A M Groenen
    Animal Breeding and Genomics Centre, Wageningen University, 6700 AH Wageningen, The Netherlands
    Genome Res 19:510-9. 2009
    ..4-fold higher density at recombination hot spots versus cold spots, suggesting a functional relationship between recombination frequency and cohesin binding...
  91. pmc Detecting copy number variation with mated short reads
    Paul Medvedev
    Department of Computer Science, University of Toronto, Toronto, Ontario M5R 3G4, Canada
    Genome Res 20:1613-22. 2010
    ..Furthermore, we demonstrate that CNVer can reconstruct the absolute copy counts of segments of the donor genome and evaluate the feasibility of using CNVer with low coverage datasets...
  92. ncbi A high-density microsatellite consensus map for bread wheat (Triticum aestivum L.)
    Daryl J Somers
    Agriculture and Agri Food Canada, Cereal Research Centre, 195 Dafoe Rd, Winnipeg, MB, Canada, R3T 2 M9
    Theor Appl Genet 109:1105-14. 2004
    ..This enables users to predict allele sizes in new breeding populations and develop molecular breeding and genomics strategies...
  93. ncbi Efficiency and power in genetic association studies
    Paul I W de Bakker
    Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge Street, CPZN 6818, Boston, Massachusetts 02114 2790, USA
    Nat Genet 37:1217-23. 2005
    ..Power is robust to the completeness of the reference panel from which tags are selected. These findings have implications for prioritizing tag SNPs and interpreting association studies...
  94. ncbi A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif
    A H Sinclair
    Human Molecular Genetics Laboratory, Imperial Cancer Research Fund, Lincoln s Inn Fields, London, UK
    Nature 346:240-4. 1990
    ..This gene has been termed SRY (for sex-determining region Y) and proposed to be a candidate for the elusive testis-determining gene, TDF...
  95. pmc Construction of a 10,000-marker ultradense genetic recombination map of potato: providing a framework for accelerated gene isolation and a genomewide physical map
    Hans van Os
    Laboratory of Plant Breeding, Wageningen University, The Netherlands
    Genetics 173:1075-87. 2006
    ..potatogenome.net)...
  96. pmc Identifying autism loci and genes by tracing recent shared ancestry
    Eric M Morrow
    Division of Genetics, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Science 321:218-23. 2008
    ....
  97. pmc MYH9 is associated with nondiabetic end-stage renal disease in African Americans
    W H Linda Kao
    Department of Epidemiology, School of Medicine and Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Nat Genet 40:1185-92. 2008
    ....
  98. pmc Discovery of common Asian copy number variants using integrated high-resolution array CGH and massively parallel DNA sequencing
    Hansoo Park
    Genomic Medicine Institute, Medical Research Center, Seoul National University, Seoul, Korea
    Nat Genet 42:400-5. 2010
    ..These common CNVs in Asian populations will be a useful resource for subsequent genetic studies in these populations, and the new method of calling absolute CNVs will be essential for applying CNV data to personalized medicine...
  99. ncbi Datamonkey: rapid detection of selective pressure on individual sites of codon alignments
    Sergei L Kosakovsky Pond
    Antiviral Research Center, University of California, San Diego, CA 92103, USA
    Bioinformatics 21:2531-3. 2005
    ..The methods range from very fast data exploration to the some of the most complex models available in public domain software, and are implemented to run in parallel on a cluster of computers...
  100. ncbi Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome
    H Hahn
    Centre for Molecular and Cell Biology, University of Queensland, St Lucia, Australia
    Cell 85:841-51. 1996
    ..We propose that a reduction in expression of the patched gene can lead to the developmental abnormalities observed in the syndrome and that complete loss of patched function contributes to transformation of certain cell types...
  101. ncbi A fine-scale map of recombination rates and hotspots across the human genome
    Simon Myers
    Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG, UK
    Science 310:321-4. 2005
    ....

Research Grants62

  1. LOW-LIGHT, SMALL, FAST, HIGH-RES HYPERSPECTRAL IMAGER
    Henryk Malak; Fiscal Year: 2001
    ..emitters and will be useful in basic research for detecting chromosome abnormalities in cancer cells; for chromosome mapping and gene localization; screening and biochip analysis; and will play an important future role in clinical ..
  2. De Novo Methyltransferase Function in Chromatin and Cancer
    Keith D Robertson; Fiscal Year: 2013
    ....
  3. Measurements of BPDE-DNA adducts by solid state nonopore and deep sequencing (PQ
    Farhad Kosari; Fiscal Year: 2013
    ..The approaches introduced here can be extended to most other toxins and carcinogens that form DNA adducts. These findings will benefit diverse areas of cancer and scientific research, such as toxicology, where adducts are studied. ..
  4. Structure, function and engineering of nuclease catalysts
    Barry L Stoddard; Fiscal Year: 2013
    ..Newly discovered endonucleases also provide raw material for the creation of new genome mapping reagents. ..
  5. A New Tool Kit for Whole-Genome Mapping and Complementation in Drosophila
    Ming Fa; Fiscal Year: 2013
    ....
  6. A dual-nanopore platform for sensing and control of polynucleotides
    TREVOR JUSTIN MORIN; Fiscal Year: 2013
    ....
  7. A New Tool Kit for Whole-Genome Mapping and Complementation in Drosophila
    Ming Fa; Fiscal Year: 2012
    ..Moreover, this resource will be in high demand for many years to come by the more than 1000 active Drosophila research laboratories around the world and will therefore create a highly marketable and profitable venture. ..
  8. PROXIMAL DETERMINANTS OF NEPHRITOGENIC AUTOIMMUNITY
    Mary H Foster; Fiscal Year: 2012
    ..Collectively, these strains model the genetic heterogeneity of human lupus, and their study should ultimately provide insight into regulatory and disease mechanisms applicable to patients. ..
  9. Single molecule DNA mapping for DNA and CNV analysis
    Ming Xiao; Fiscal Year: 2012
    ..In this proposal, we aim to develop and optimize a single molecule mapping approach that will make de novo sequence assembly and structural variation analysis possible. ..
  10. Developing Statistical Methods for Disease Gene Discovery
    Mingyao Li; Fiscal Year: 2012
    ..This application proposes developing new statistical methodologies that address a set of unresolved issues. ..
  11. The In Silico Genetic Analysis of Opioid Adaptations
    David J Clark; Fiscal Year: 2013
    ..Additional collaboration has been arranged with an expert on complementary integrative genomics approaches involving QTL results, expression data, and other strategies further enhancing the power of the project. ..
  12. RAPD MARKERS FOR HELMINTHS
    Steven Nadler; Fiscal Year: 1993
    ..Thus, midwestern A. suum populations can serve as an excellent model system for developing methods for the applications of RAPD technology to studies of helminth systematics. ..
  13. FLUORESCENT GENE MAPPING AT INTERPHASE & METAPHASE
    Jeanne Lawrence; Fiscal Year: 1993
    ..This method provides significant advantages in resolution, speed and convenience for metaphase chromosome mapping as well, which will be demonstrated by precise metaphase localization of specific cellular genes, including ..
  14. CHEMILUMINESCENT MULTIPLEX GENOME MAPPING
    John Fox; Fiscal Year: 1992
    ..This data will be useful for positioning cloned DNA segments relative to each other. This system will greatly simplify the current radioactive methods for multiplex genome mapping...
  15. T CRUZI GENOME: UU
    Bjorn Andersson; Fiscal Year: 2004
    ..abstract_text> ..
  16. APPLYING GENOME MISMATCH SCANNING TO THE HUMAN GENOME
    Patrick Brown; Fiscal Year: 1999
    ..2. Further developing the enzymatic and hybridization steps in the procedure. 3. Developing PCR- based variations on GMS for affected relative pair and linkage disequilibrium mapping in the human genome. ..
  17. REGULATION AS A BASIS FOR ORGANISMAL DIFFERENCES
    Allan Wilson; Fiscal Year: 1991
    ..Extensive sequencing of cloned and enzymatically amplified regions combined with chromosome mapping and walking and transient expression tests should permit characterization of the lysozyme gene clusters in ..
  18. REGULATION AS A BASIS FOR ORGANISMAL DIFFERENCES
    JACK KIRSCH; Fiscal Year: 1993
    ..Extensive sequencing of cloned and enzymatically amplified regions combined with chromosome mapping and walking and transient expression tests should permit characterization of the lysozyme gene clusters in ..
  19. Genome Mapping Resources for the Budgerigar
    Edward Smith; Fiscal Year: 2002
    ..abstract_text> ..
  20. Regulation of hemolysin genes in Bacillus
    Michiko Nakano; Fiscal Year: 2007
    ..subtilis. [unreadable] [unreadable] [unreadable]..
  21. HICSS-26 CONFERENCE--MINITRACK ON GENOME INFORMATICS
    Charles Lawrence; Fiscal Year: 1993
    ..INTEGRATED SOFTWARE ENVIRONMENTS: Laboratory database management systems and software environments that integrate and support the process of large-scale mapping and sequencing...
  22. CHROMOSOME MAPPING BY A DNA CIRCULARIZATION TECHNIQUE
    Francis Collins; Fiscal Year: 1992
    ..This would be of great utility in cloning the gene responsible for a Mendelian disease, once the location has been narrowed down by linkage analysis and physical mapping...
  23. GENETIC LINKAGE STUDY OF ALCOHOLISM
    Raymond Crowe; Fiscal Year: 1993
    ..Cell lines will be shared with other collaborating centers for a systematic search for alcoholism disease genes at a laboratory to be decided upon by the collaborators...
  24. FISSION YEAST GENOME MAPPING
    David Beach; Fiscal Year: 1992
    ..is to be used to develop improved methods for cloning large fragments of mammalian DNA for the purpose of chromosome mapping. A map of the 14 megabase genome of S...
  25. CREATION OF VERY RARE CUT SITES FOR GENOME MAPPING
    Waclaw Szybalski; Fiscal Year: 1993
    ..This capability renders the AC procedure potentially useful in the mapping and sequencing of large eukaryotic genomes, including the human genome...
  26. MAMMALIAN GENOME MAPPING OF TISSUE SPECIFIC CDNAS
    Michael Seldin; Fiscal Year: 1999
    ..The database will be integrated with the online Gene Map of the Human Genome and will be annotated to include unmapped mouse orthologues of human unigenes and their putative chromosomal location. ..
  27. GENETIC LINKAGE OF SCHIZOPHRENIA USING A GENOME MAP
    Douglas Levinson; Fiscal Year: 1999
    ....
  28. SEQUENCE-SPECIFIC CHEMICAL NUCLEASES FOR GENOME ANALYSIS
    David Sigman; Fiscal Year: 1993
    ..Finally, the cro protein will be modified by site-directed mutagenesis to target the nuclease activity of OP-Cu. All three procedures could be used to develop sequence-specific nucleases for any preselected sequence...
  29. DROSOPHILA GENOME MAPPING USING YAC VECTORS
    Daniel Hartl; Fiscal Year: 1991
    ....
  30. COULTER ELITE FLOW CYTOMETRY SYSTEM
    Robert Todd; Fiscal Year: 1991
    ..The operating costs of the current Flow Cytometry Laboratory and the proposed new (replacement) instrumentation will be shared by NIH Core Grants from the Cancer and Arthritis Centers as supplemented by a users fee...
  31. INTERNATIONAL WORKSHOP ON CHROMOSOME 22
    Beverly Emanuel; Fiscal Year: 1990
    ..The meeting is intended to broaden collaborative efforts and to foster more extensive scientific interchange...
  32. IRON AND COPPER IN HEALTH AND DISEASE
    Christopher Vulpe; Fiscal Year: 2001
    ..The location of sla gene will be refined with an inter-specific cross, ancestral chromosome mapping, and exclusion mapping and a physical map of sla region will be constructed...
  33. GENOME MAPPING AND SEQUENCING CONFERENCE
    TERRI GRODZICKER; Fiscal Year: 2001
    ..The meetings will be international in nature, with an anticipated yearly attendance of 400-450 investigators. ..
  34. FOURTH INTERNATIONAL WORKSHOP ON MOUSE GENOME MAPPING
    VERNE CHAPMAN; Fiscal Year: 1990
    ....
  35. SOFTWARE AND INSTRUMENTATION FOR MAPPING AND SEQUENCING
    CHARLES MAGNESS; Fiscal Year: 1999
    ..These areas are well suited to the task of developing process automation and data analysis for genome mapping and sequencing. ..
  36. SEARCH FOR NEW RESTRICTION ENDONUCLEASES
    Richard Roberts; Fiscal Year: 1992
    ..While this work will impact all areas of molecular biology, it is of special importance for chromosome mapping and genetic engineering.
  37. Genetic Epidemiology of CVD Risk Factors
    ROGER SIERVOGEL; Fiscal Year: 2006
    ..Following these linkage analyses, we will examine more closely our strongest linkage signals with fine mapping linkage analysis in order to narrow chromosomal regions of interest. ..
  38. Genetic Epidemiology of CVD Risk Factors
    Shelley Cole; Fiscal Year: 2006
    ..Following these linkage analyses, we will examine more closely our strongest linkage signals with fine mapping linkage analysis in order to narrow chromosomal regions of interest. ..
  39. ENHANCING THE VALUE OF THE C ELEGANS GENOME SEQUENCE
    Robert Waterston; Fiscal Year: 2003
    ..elegans genome dictates the development, behavior, and other biology of this small but complex animal. In turn, the principles learned here should help to unlock the information stored in other animal genomes, including human. ..
  40. POLYMORPHIC GENES MODULATING LIFESPAN IN C ELEGANS
    ROBERT SHMOOKLER REIS; Fiscal Year: 2002
    High-resolution chromosome mapping will be used to identify and characterize genes which normally govern adult longevity in the nematode Caenorhabditis elegans. By studying the genetics of aging model organisms such as C...
  41. AFRICAN TRYPANOSOME GENOME SEQUENCING
    Najib El Sayed; Fiscal Year: 2003
    ..TIGR has since provided an invaluable scaffold for chromosome mapping in the form of approximately 11,000 BAC and P1 end sequences, and approximately 37,000 shotgun sequences for ..
  42. DEVELOPMENT OF SYSTEMS FOR RAPID CHROMOSOME MAPPING
    Paul Siebert; Fiscal Year: 1992
    ..With this system chromosome mapping can then be performed in several ways; (1) By hybridization of cDNA or gene fragment probes to amplified ..
  43. NEW CLASS OF GENOME RARE CUTTERS
    Maxim Frank Kamenetskii; Fiscal Year: 1999
    ..This is the range where very few cutters, if any, are presently available. This could significantly simplify numerous techniques in the entire field of DNA analysis, including genome mapping, cloning and sequencing. ..
  44. CONFERENCE ON MANIPULATING THE MAMMALIAN GENOME
    Charles Fox; Fiscal Year: 1990
    ..The meeting will facilitate communication in the rapidly progressing fields of muse genetics and human biology and disease...
  45. 2ND INTERNATIONAL WORKSHOP ON CHROMOSOME 22
    Beverly Emanuel; Fiscal Year: 1991
    ..The workshop will serve to determine the most efficient methods for completing a detailed genetic and physical map of human chromosome 22...
  46. ONE-STEP PCR CLONING SYSTEM BASED ON FLP-RECOMBINATION
    Peter Vaillancourt; Fiscal Year: 1993
    ....
  47. Agencourt Sequencing Center
    Douglas Smith; Fiscal Year: 2006
    ..The genome sequences will be annotated through collaborations with the appropriate user communities and experienced genome analysis experts. ..
  48. Haplotype Sequencing via Single Molecule Hybridization
    Bhubaneswar Mishra; Fiscal Year: 2006
    ..falciparum genome (small-size), (3) more complex validation by sequencing 100bp segment of H. sapiens genome (large-size), (4) final system engineering and validation by sequencing the entire H. sapiens genome. [unreadable] [unreadable]..
  49. DROSOPHILA DATABASE WORKSHOP
    Daniel Hartl; Fiscal Year: 1990
    ..One of the prime objectives should be to integrate the Drosophila database with those of other organisms...
  50. DEVELOPMENT OF SNP ANALYSIS FOR GENETIC VARIATION
    Christopher Becker; Fiscal Year: 1999
    ..abstract_text> ..
  51. CHROMOSOME 17 MAPPING WORKSHOP
    Pamela Fain; Fiscal Year: 1990
    ..The goals of the conference are to integrate mapping data from a variety of sources, to identify gaps and inconsistencies in the composite map, and to encourage collaborative efforts to resolve these problems...
  52. THIRD INTERNATIONAL WORKSHOP ON CHROMOSOME 22
    Beverly Emanuel; Fiscal Year: 1992
    ....
  53. TOTAL HUMAN YAC LIBRARY
    TERRY LERNER; Fiscal Year: 1990
    ..The specific aims of this proposal are to optimize library construction and to verify the authenticity of the clones by Southern blot analysis and in situ cytogenetics...
  54. DEVELOPMENT OF NOVEL DNA MICROARRAYS FOR HLA TYPING
    PETER FLOWERS; Fiscal Year: 1999
    ..abstract_text> ..
  55. TARGETING OF SELECTABLE MARKERS TO ANY GENETIC LOCUS
    Greg Landes; Fiscal Year: 1990
    ..At the genome level, a set of targeting vectors, each directed to chromosomal locations separated by 10-20 Mb, could generate an ordered set of "transgenome". These reagents would enhance current and future human genome mapping efforts...
  56. Rapid and Inexpensive Multi-allele Cystic Fibrosis Assay
    JAMES PRUDENT; Fiscal Year: 2004
    ..In addition, validation from this project will open the doors to other test kit development such as population carrier screening for other genetic diseases and research based chromosome mapping studies.