multicenter studies

Summary

Summary: Controlled studies which are planned and carried out by several cooperating institutions to assess certain variables and outcomes in specific patient populations, for example, a multicenter study of congenital anomalies in children.

Top Publications

  1. ncbi Protocol core needle biopsy and histologic Chronic Allograft Damage Index (CADI) as surrogate end point for long-term graft survival in multicenter studies
    Serdar Yilmaz
    Data Analysis Center, Division of Transplantation, Department of Surgery, University of Calgary, Alberta, Canada
    J Am Soc Nephrol 14:773-9. 2003
  2. ncbi Internet based multi-institutional clinical research: a convenient and secure option
    Costas D Lallas
    Division of Urology, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
    J Urol 171:1880-5. 2004
  3. ncbi Two-year incidence of malignancy in sirolimus-treated renal transplant recipients: results from five multicenter studies
    Timothy Mathew
    Renal Unit, Queen Elizabeth Hospital, Woodville, South Australia, Australia
    Clin Transplant 18:446-9. 2004
  4. ncbi Intratester and intertester reliability of clinical measures of lower extremity anatomic characteristics: implications for multicenter studies
    Sandra J Shultz
    Applied Neuromechanics Research Laboratory, 237B HHP, University of North Carolina at Greensboro, Greensboro, NC 27402, USA
    Clin J Sport Med 16:155-61. 2006
  5. ncbi A review finds that multicenter studies face substantial challenges but strategies exist to achieve Institutional Review Board approval
    Sarah M Greene
    Group Health Cooperative Center for Health Studies, 1730 Minor Avenue, Suite 1600, Seattle, WA 98101, USA
    J Clin Epidemiol 59:784-90. 2006
  6. pmc Notes from the field: jumpstarting the IRB approval process in multicenter studies
    Jan Blustein
    Wagner Graduate School, New York University, Puck Building, 295 Lafayette Street, New York, NY 10012, USA
    Health Serv Res 42:1773-82. 2007
  7. ncbi Criterion validity of Medicare chemotherapy claims in Cancer and Leukemia Group B breast and lung cancer trial participants
    Elizabeth B Lamont
    Department of Medicine and Institute for Technology Assessment, Massachusetts General Hospital, Boston, MA 02114, USA
    J Natl Cancer Inst 97:1080-3. 2005
  8. ncbi The independent statistician for data monitoring committees
    David L Demets
    Department of Biostatistics and Medical Informatics, University of Wisconsin Madison, 600 Highland Avenue, Box 4675, Madison, WI 53792 4675, USA
    Stat Med 23:1513-7. 2004
  9. ncbi Improved quality of life in patients with overactive bladder symptoms treated with solifenacin
    Con J Kelleher
    Guy s and St Thomas Hospital, London, UK
    BJU Int 95:81-5. 2005
  10. ncbi The reliability of echocardiographic left ventricular wall motion index to identify high-risk patients for multicenter studies
    Gunnar H Gislason
    Department of Cardiovascular Medicine, Bispebjerg University Hospital, Copenhagen, Denmark
    Echocardiography 23:1-6. 2006

Detail Information

Publications252 found, 100 shown here

  1. ncbi Protocol core needle biopsy and histologic Chronic Allograft Damage Index (CADI) as surrogate end point for long-term graft survival in multicenter studies
    Serdar Yilmaz
    Data Analysis Center, Division of Transplantation, Department of Surgery, University of Calgary, Alberta, Canada
    J Am Soc Nephrol 14:773-9. 2003
    ..This observation makes it possible to use CADI as a surrogate end point in prevention trials and to identify the patients at risk for intervention trials...
  2. ncbi Internet based multi-institutional clinical research: a convenient and secure option
    Costas D Lallas
    Division of Urology, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
    J Urol 171:1880-5. 2004
    ..Internet based clinical studies have been found to be a rapid, easily accessible, safe and secure method of performing multi-institutional trials...
  3. ncbi Two-year incidence of malignancy in sirolimus-treated renal transplant recipients: results from five multicenter studies
    Timothy Mathew
    Renal Unit, Queen Elizabeth Hospital, Woodville, South Australia, Australia
    Clin Transplant 18:446-9. 2004
    ..SRL immunotherapy may be beneficial in protecting renal transplant patients from skin cancer even when given in combination with CsA...
  4. ncbi Intratester and intertester reliability of clinical measures of lower extremity anatomic characteristics: implications for multicenter studies
    Sandra J Shultz
    Applied Neuromechanics Research Laboratory, 237B HHP, University of North Carolina at Greensboro, Greensboro, NC 27402, USA
    Clin J Sport Med 16:155-61. 2006
    ..We also determined whether testers trained 18 months apart could perform these measurements with good agreement...
  5. ncbi A review finds that multicenter studies face substantial challenges but strategies exist to achieve Institutional Review Board approval
    Sarah M Greene
    Group Health Cooperative Center for Health Studies, 1730 Minor Avenue, Suite 1600, Seattle, WA 98101, USA
    J Clin Epidemiol 59:784-90. 2006
    ..To characterize the impact of multiple Institutional Review Board (IRB) reviews on multicenter observational research studies, and identify strategies for overcoming the identified challenges...
  6. pmc Notes from the field: jumpstarting the IRB approval process in multicenter studies
    Jan Blustein
    Wagner Graduate School, New York University, Puck Building, 295 Lafayette Street, New York, NY 10012, USA
    Health Serv Res 42:1773-82. 2007
    To identify strategies that facilitate readiness for local Institutional Review Board (IRB) review, in multicenter studies.
  7. ncbi Criterion validity of Medicare chemotherapy claims in Cancer and Leukemia Group B breast and lung cancer trial participants
    Elizabeth B Lamont
    Department of Medicine and Institute for Technology Assessment, Massachusetts General Hospital, Boston, MA 02114, USA
    J Natl Cancer Inst 97:1080-3. 2005
    ..Administrative Medicare claims data appear to be a valid source of information for chemotherapy administered to elderly Medicare beneficiaries with cancer...
  8. ncbi The independent statistician for data monitoring committees
    David L Demets
    Department of Biostatistics and Medical Informatics, University of Wisconsin Madison, 600 Highland Avenue, Box 4675, Madison, WI 53792 4675, USA
    Stat Med 23:1513-7. 2004
    ..These views are based on having served as members of many DMCs as well as having been the independent statistician for several trials...
  9. ncbi Improved quality of life in patients with overactive bladder symptoms treated with solifenacin
    Con J Kelleher
    Guy s and St Thomas Hospital, London, UK
    BJU Int 95:81-5. 2005
    ..To assess the effect of solifenacin succinate treatment on quality of life (QoL) measured in clinical trials in patients with overactive bladder (OAB)...
  10. ncbi The reliability of echocardiographic left ventricular wall motion index to identify high-risk patients for multicenter studies
    Gunnar H Gislason
    Department of Cardiovascular Medicine, Bispebjerg University Hospital, Copenhagen, Denmark
    Echocardiography 23:1-6. 2006
    ..To study whether the use of echocardiographic left ventricular (LV) wall motion index (WMI) is a dependable parameter for identifying patients with LV dysfunction to be enrolled in multicenter trials...
  11. ncbi A pooled analysis of telithromycin in the treatment of community-acquired respiratory tract infections in adults
    C Carbon
    Infection 31:308-17. 2003
    ..Thirteen multinational, Phase III studies were conducted to establish the efficacy of telithromycin 800 mg once daily in the treatment of community-acquired respiratory tract infections (RTIs)...
  12. ncbi The oral NK(1) antagonist aprepitant for the prevention of acute and delayed chemotherapy-induced nausea and vomiting: Pooled data from 2 randomised, double-blind, placebo controlled trials
    David G Warr
    Princess Margaret Hospital, 610 University Avenue, Toronto, Ont, Canada M5G 2M9
    Eur J Cancer 41:1278-85. 2005
    ..In addition, even among patients who had emesis or needed rescue therapy, aprepitant was associated with a lower frequency of these events compared with the control regimen...
  13. ncbi Comparison of effectiveness of sirolimus-eluting stents versus bare metal stents for percutaneous coronary intervention in patients at high risk for coronary restenosis or clinical adverse events
    Antonio Marzocchi
    Istituto di Cardiologia, Universita di Bologna, Policlinico S Orsola Malpighi, Bologna, Italy
    Am J Cardiol 95:1409-14. 2005
    ....
  14. ncbi [New drugs and treatment strategies for rheumatoid arthritis]
    Flavio Fantini
    Cattedra di Reumatologia Università, Unità Operativa di Reumatologia, Azienda Ospedaliera Istituto Ortopedico Gaetano Pini, Milano
    Recenti Prog Med 94:361-79. 2003
    ....
  15. ncbi Clinical results of ProDisc-II lumbar total disc replacement: report from the United States clinical trial
    Rick B Delamarter
    Spine Research Foundation, The Spine Institute at Saint John s Health Center, Suite 400, 1301 20th Street, Santa Monica, CA 90404, USA
    Orthop Clin North Am 36:301-13. 2005
    ..This is a review of the clinical performance of the ProDisc-II artificial disc and includes an interim report from the US IDE trial at one site...
  16. ncbi Guidelines for lowering lipids to reduce coronary artery disease risk: a comparison of rosuvastatin with atorvastatin, pravastatin, and simvastatin for achieving lipid-lowering goals
    James Shepherd
    Department of Pathological Biochemistry, Royal Infirmary, University of Glasgow, Scotland, United Kingdom
    Am J Cardiol 91:11C-17C; discussion 17C-19C. 2003
    ..001). A total of 71% of patients treated with rosuvastatin 10 mg who had triglyceride levels > or =200 mg/dL met both their LDL cholesterol and their non-high-density lipoprotein cholesterol goals...
  17. ncbi Prognosis of inv(16)/t(16;16) acute myeloid leukemia (AML): a survey of 110 cases from the French AML Intergroup
    Jacques Delaunay
    Departement of Hematology, Hopital Saint Louis, Paris, France
    Blood 102:462-9. 2003
    ..These results markedly contrast with those reported in patients with t(8;21) AML in whom WBC, and not age, was the main high-risk factor for relapse, DFS, and survival...
  18. pmc Risk factors, medical therapies and perioperative events in limb salvage surgery: observations from the PREVENT III multicenter trial
    Michael S Conte
    Brigham and Women s Hospital, Boston, MA 02115, USA
    J Vasc Surg 42:456-64; discussion 464-5. 2005
    ..We examined the baseline characteristics, perioperative medical therapies, and 30-day incidence of major cardiovascular events in the PREVENT III cohort...
  19. ncbi Intra-cardiac echocardiography guided cardioversion to help interventional procedures (ICE-CHIP) study: study design and methods
    Hygriv B Rao
    Electrophysiology Research Foundation, Warren, NJ, USA
    J Interv Card Electrophysiol 13:31-6. 2005
    ..The composite incidence rate of major cardiac and bleeding complications (stroke, TIA, peripheral embolism, major hemorrhagic event) will be compared between the two treatment groups over the duration of the study...
  20. ncbi Letrozole in the extended adjuvant treatment of postmenopausal women with history of early-stage breast cancer who have completed 5 years of adjuvant tamoxifen
    Bhupinder S Mann
    Division of Oncology Drug Products, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20857, USA
    Clin Cancer Res 11:5671-7. 2005
    ....
  21. ncbi Subject's Global Assessment of Relief: an appropriate method to assess the impact of treatment on irritable bowel syndrome-related symptoms in clinical trials
    Stefan Müller-Lissner
    Park Klinik Berlin Weissensee, Schoönstrasse 80, D 13086 Berlin, Germany
    J Clin Epidemiol 56:310-6. 2003
    ..The SGA of Relief is reliable as a new outcome measure for assessing response to therapy in IBS patients and has demonstrated responsiveness and reproducibility...
  22. ncbi [Finasteride: 10 years of clinical use. Systematic review of the literature]
    J F Jimenez Cruz
    Servicio de Urologia, Hospital Universitario La Fe, Valencia
    Actas Urol Esp 27:202-15. 2003
    ..After ten years of clinical use of Finasteride in patients with BPH, we carried out a systematic review of the literature including the assessment of their quality and grading the level of evidence for clinical recommendations...
  23. ncbi Treatment of overactive bladder in the older patient: pooled analysis of three phase III studies of darifenacin, an M3 selective receptor antagonist
    Jenelle Foote
    Midtown Urology and Surgical Center, Atlanta, GA, USA
    Eur Urol 48:471-7. 2005
    ....
  24. ncbi [Clinical experiences with pregabalin in the treatment of focal epilepsies]
    A Gil-Nagel Rein
    Servicio de Neurologia, Hospital Ruber Internacional, La Maso 38, Mirasierra, E 28034 Madrid, Spain
    Rev Neurol 40:609-13. 2005
    ..Pregabalin is an antiepileptic drug recently approved in the European Union for add-on therapy of focal epilepsy. A review of its clinical and pharmacological characteristics is, therefore, appropriate...
  25. ncbi Design and baseline characteristics of the stroke prevention by aggressive reduction in cholesterol levels (SPARCL) study
    Peirre Amarenco
    Cerebrovasc Dis 16:389-95. 2003
    ..SPARCL is the first study primarily designed to prospectively evaluate the effect of statin treatment in secondary stroke prevention...
  26. ncbi Effect of pioglitazone on metabolic syndrome risk factors: results of double-blind, multicenter, randomized clinical trials
    Rukmini Rajagopalan
    Takeda Pharmaceuticals North America, Inc, 475 Half Day Road, Lincolnshire, IL 60069, USA
    Curr Med Res Opin 21:163-72. 2005
    ..To evaluate the effect of pioglitazone, metformin, and/or sulfonylurea on metabolic syndrome and its component parameters after a year of treatment...
  27. ncbi The current understanding of lamotrigine as a mood stabilizer
    Chang Gyu Hahn
    Department of Psychiatry, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    J Clin Psychiatry 65:791-804. 2004
    ..To examine whether lamotrigine has a unique role in the treatment of bipolar disorder, we evaluated the results of recent clinical trials and molecular and cell biological studies on lamotrigine...
  28. ncbi Semi-parametric and non-parametric methods for clinical trials with incomplete data
    Peter C O'Brien
    Division of Biostatistics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Stat Med 24:341-58. 2005
    ....
  29. ncbi [Atrial fibrillation: rhythm control versus rate control? (New evidences from clinical trials)]
    Regina Auskalniene
    Clinic of Cardiology, Kaunas University of Medicine Hospital, Lithuania
    Medicina (Kaunas) 40:598-603. 2004
    ..5 years) is not known. The purpose of this article is to discuss some important aspects of atrial fibrillation and to review recent developments in the management of this condition...
  30. ncbi The Canadian Optimal Therapy of COPD Trial: design, organization and patient recruitment
    Shawn D Aaron
    The Ottawa Health Research Institute, University of Ottawa, Ottawa, Canada
    Can Respir J 11:581-5. 2004
    ....
  31. ncbi [Vascular surgery in the elderly]
    D Böckler
    Abteilung für Gefässchirurgie, Vaskuläre und Endovaskuläre Chirurgie, Ruprecht Karls Universitat Heidelberg
    Chirurg 76:113-25. 2005
    ..Advanced age should not be considered as a limitation or contraindication for carotid, aneurysm and bypass surgery. Age is not a disease, it is just a chapter of life...
  32. pmc Fast recruiting clinical trials--a utopian dream or logistical nightmare?
    L Johnson
    ICR CTSU, Section of Clinical Trials, Brookes Lawley Building, Institute of Cancer Research, Cotswold Road, Sutton, Surrey SM2 5NG, UK
    Br J Cancer 92:1679-83. 2005
    ..g. biological substudies), the relevance of which may only become apparent as the trial progresses. Many of these challenges were highlighted by recent experience with the Cancer Research UK Taxotere as Adjuvant Chemotherapy trial...
  33. ncbi Aromatase inhibitors and breast cancer: time for a change?
    I S Fentiman
    GKT School of Medicine, Guy s Hospital, London, UK
    Int J Clin Pract 58:1152-8. 2004
    ..Additionally, they have been demonstrated to be superior as both adjuvant and neoadjuvant treatment. It is likely that they will also be useful for breast cancer prevention but the cost/benefit ratio has yet to be determined...
  34. ncbi The Gini coefficient as a measure for understanding accrual inequalities in multicenter clinical studies
    Anna Bettina Haidich
    Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    J Clin Epidemiol 57:341-8. 2004
    ..Clinical sites participating in multicenter trials may have unequal performance in recruiting subjects. We propose using the Gini coefficient as a quantitative measure of site accrual inequalities...
  35. ncbi Designing the Selenium and Vitamin E Cancer Prevention Trial (SELECT)
    Scott M Lippman
    The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    J Natl Cancer Inst 97:94-102. 2005
    ....
  36. ncbi Cardiac resynchronization therapy for the management of chronic heart failure
    William T Abraham
    Department of Internal Medicine, Division of Cardiovascular Medicine, Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH, USA
    Am Heart Hosp J 1:55-61. 2003
    ..Thus, cardiac resynchronization therapy should be routinely considered in eligible NYHA class III and IV heart failure patients with ventricular dyssynchrony...
  37. ncbi A pooled analysis of three phase III studies to investigate the efficacy, tolerability and safety of darifenacin, a muscarinic M3 selective receptor antagonist, in the treatment of overactive bladder
    Christopher Chapple
    Urology Research, Royal Hallamshire Hospital, Sheffield, UK
    BJU Int 95:993-1001. 2005
    ....
  38. ncbi Epidural analgesia for pain relief in labour and childbirth - a review with a systematic approach
    Astrid Nystedt
    Obstetrics and Gynaecology, Department of Clinical Science, Umea University, Umea, Sweden
    J Clin Nurs 13:455-66. 2004
    ..Clinical ambiguity concerning effects of epidural analgesia for pain relief in labour seems to reflect a need for evidence-based knowledge for midwives...
  39. ncbi [Outpatient antibiotherapy in children with neutropenia and fever. A review of the literature]
    Guy Leverger
    Service d Onco Hématologie Pédiatrique, Hopital Trousseau, Paris
    Presse Med 33:330-7. 2004
    ....
  40. ncbi Cognitive performance in Alzheimer's disease patients receiving rivastigmine for up to 5 years
    G W Small
    UCLA Neuropsychiatric Institute, Los Angeles, CA 90024 1759, USA
    Int J Clin Pract 59:473-7. 2005
    ..3 (+/-4.9). Projected mean scores in model-based untreated patients declined below 10 points on the MMSE at about 3 years, while the mean MMSE score of patients who remained on rivastigmine stayed above 10 points for 5 years...
  41. ncbi Methods of testing feasibility for sequenced treatment alternatives to relieve depression (STAR*D)
    Stephen R Wisniewski
    Epidemiology Data Center, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Psychiatr Res 38:241-8. 2004
    ..While the information gathered was useful, it did delay the initiation of the formal trial. We view this cost as an investment in the development of overall study procedures that should lead to a stronger study...
  42. ncbi [Contribution of large clinical studies to daily practices]
    A Bron
    Service d Ophtalmologie, Hopital General, BP 1519, 21033 Dijon Cedex
    J Fr Ophtalmol 27:689-92. 2004
    ....
  43. ncbi Rationale and design of a randomized trial to assess the effects of beta-blocker in diastolic heart failure; Japanese Diastolic Heart Failure Study (J-DHF)
    Masatsugu Hori
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Japan
    J Card Fail 11:542-7. 2005
    ....
  44. ncbi Health outcomes and cost-effectiveness of aprepitant in outpatients receiving antiemetic prophylaxis for highly emetogenic chemotherapy in Germany
    Florian Lordick
    Third Medical Department, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Str 22, 81675 Munchen, Germany
    Eur J Cancer 43:299-307. 2007
    ..We aimed to determine outcomes associated with use of aprepitant in outpatients undergoing highly emetogenic chemotherapy in Germany from a patient's and payer's perspective...
  45. ncbi Substance use in persons with schizophrenia: baseline prevalence and correlates from the NIMH CATIE study
    Marvin S Swartz
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27710, USA
    J Nerv Ment Dis 194:164-72. 2006
    ....
  46. ncbi A mechanism-based disease progression model for comparison of long-term effects of pioglitazone, metformin and gliclazide on disease processes underlying Type 2 Diabetes Mellitus
    Willem de Winter
    LAP and P Consultants BV, Leiden, The Netherlands
    J Pharmacokinet Pharmacodyn 33:313-43. 2006
    ....
  47. ncbi Impact of metabolic syndrome on prognosis of symptomatic intracranial atherostenosis
    Bruce Ovbiagele
    Stroke Center, Department of Neurology, UCLA Medical Center, Los Angeles, CA, USA
    Neurology 66:1344-9. 2006
    ..The authors evaluated the prevalence and prognosis of the MetS among individuals with symptomatic intracranial arterial stenosis...
  48. ncbi SELECT: the selenium and vitamin E cancer prevention trial
    Eric A Klein
    Section of Urologic Oncology, Department of Urology, Cleveland Clinic Foundation, Cleveland, OH, USA
    Urol Oncol 21:59-65. 2003
    ..SELECT is a randomized, prospective, double-blind study designed to determine if selenium and vitamin E can reduce the risk of prostate cancer among healthy men...
  49. ncbi Efficacy of an intrapocket anesthetic for scaling and root planing procedures: a review of three multicenter studies
    Allison DiMatteo
    DENTSPLY International, Inc, York, PA 17405, USA
    Compend Contin Educ Dent 26:6-10. 2005
    In recent years, three multicenter studies have been conducted to evaluate the clinical efficacy of an active 5% dental gel to reduce pain when placed into periodontal pockets before initiating scaling and root planing procedures...
  50. ncbi The Pacing to Avoid Cardiac Enlargement (PACE) trial: clinical background, rationale, design, and implementation
    Jeffrey Wing Hong Fung
    Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    J Cardiovasc Electrophysiol 18:735-9. 2007
    ..However, the optimal pacing mode and site(s) for patients with normal LV systolic function remain controversial...
  51. ncbi Asenapine in the treatment of negative symptoms of schizophrenia: clinical trial design and rationale
    Larry Alphs
    Pfizer Global R and D, Ann Arbor, Michigan 48105, USA
    Psychopharmacol Bull 40:41-53. 2007
    ....
  52. ncbi Clinical trial design and patient demographics of the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) study program: cardiovascular outcomes with etoricoxib versus diclofenac in patients with osteoarthritis and rheumatoid arthritis
    Christopher P Cannon
    The TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am Heart J 152:237-45. 2006
    ..The MEDAL program will help to better define the risk-to-benefit ratio of 2 NSAIDs, that differ in their selectivity for COX-2, notably diclofenac and etoricoxib...
  53. pmc Solifenacin significantly improves all symptoms of overactive bladder syndrome
    C R Chapple
    Department of Urology, The Royal Hallamshire Hospital, Sheffield, UK
    Int J Clin Pract 60:959-66. 2006
    ..Adverse events were mainly mild-to-moderate in all treatment groups. The results of these phase III trials support the use of solifenacin in the treatment of OAB...
  54. ncbi Preventing type 2 diabetes using combination therapy: design and methods of the CAnadian Normoglycaemia Outcomes Evaluation (CANOE) trial
    B Zinman
    Leadership Sinai Centre for Diabetes, Department of Medicine, Mount Sinai Hospital and the University of Toronto, Toronto, Ontario, Canada
    Diabetes Obes Metab 8:531-7. 2006
    ..In conclusion, the CANOE study will determine whether combination pharmacological therapy combined with a lifestyle intervention programme can significantly modify the development of diabetes in high-risk Canadians...
  55. ncbi Do we know the optimal dose for renal replacement therapy in the intensive care unit?
    R Bellomo
    Department of Intensive Care, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia
    Kidney Int 70:1202-4. 2006
    ..The results of these two studies should be available in 2008. Before making any major changes to practice, it seems prudent to wait for the publication of the findings of these two pivotal trials...
  56. ncbi Treatment of agitation and aggression in bipolar mania: efficacy of quetiapine
    Peter F Buckley
    Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Affect Disord 100:S33-43. 2007
    ..Agitation and aggression are potentially disruptive and dangerous features of bipolar mania. This analysis evaluated the effects of quetiapine on agitation and aggression in patients with bipolar I mania...
  57. ncbi The Managed Ventricular pacing versus VVI 40 Pacing (MVP) Trial: clinical background, rationale, design, and implementation
    Michael O Sweeney
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Cardiovasc Electrophysiol 17:1295-8. 2006
    ..Right ventricular apical (RVA) pacing has been implicated in worsening heart failure and death. The optimal pacemaker mode for bradycardia support while minimizing unnecessary and potentially harmful RVA pacing has not been determined...
  58. ncbi Upper gastrointestinal tract safety of risedronate: a pooled analysis of 9 clinical trials
    Hugh Taggart
    Department of Health Care for the Elderly, Belfast City Hospital, Belfast, Northern Ireland, United Kingdom
    Mayo Clin Proc 77:262-70. 2002
    ..The results of this extensive evaluation indicate that daily treatment with 5 mg of risedronate sodium is not associated with an increased frequency of adverse GI tract effects, even among patients at high risk for these events...
  59. ncbi The evaluation of subcutaneous proleukin (interleukin-2) in a randomized international trial: rationale, design, and methods of ESPRIT
    Sean Emery
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Level 2, 376 Victoria Street, Sydney, NSW 2010, Australia
    Control Clin Trials 23:198-220. 2002
    ..This article describes the rationale supporting the trial in addition to reviewing the study design, coordination, and governance...
  60. ncbi Issues in the design of multisite clinical trials of psychotherapy: VA Cooperative Study No. 494 as an example
    Paula P Schnurr
    VA National Center for PTSD, White River Junction, VT 05009, USA
    Contemp Clin Trials 26:626-36. 2005
    ..Discussion includes issues encountered in multisite psychotherapy trials along with the rationale for our decisions about how we addressed these issues in CSP #494...
  61. ncbi Design and statistical issues in the homocysteinemia in kidney and end stage renal disease (HOST) study
    Rex L Jamison
    Division of Nephrology, Stanford University School of Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Clin Trials 1:451-60. 2004
    ..Data will be stored and analyzed at a coordinating center. The study design has the power to detect a reduction in all cause mortality rate of 17%. Issues related to the unique features of the design of this study are discussed...
  62. ncbi Meta-analysis of results from eight randomized, placebo-controlled trials on the effect of cilostazol on patients with intermittent claudication
    Paul D Thompson
    Hartford Hospital, Hartford, Connecticut 06102, USA
    Am J Cardiol 90:1314-9. 2002
    ..8%, but there were no deleterious effects on any hematologic or serum markers. We conclude that cilostazol significantly increases walking distance and quality-of-life measures in patients with claudication without major adverse effects...
  63. ncbi Patterns of clinically detectable treatment effects with galantamine: a qualitative analysis
    Christine Joffres
    Geriatric Medicine Research Unit, Queen Elizabeth II Health Sciences Centre, Halifax, Canada
    Dement Geriatr Cogn Disord 15:26-33. 2003
    ..Clinicians appear to be skeptical of cognitive changes not supported by like changes in function or behaviour...
  64. ncbi Dropout rates in placebo-controlled and active-control clinical trials of antipsychotic drugs: a meta-analysis
    Georg Kemmler
    Department of General Psychiatry, Innsbruck University Clinics, Anichstrasse 35, A 6020 Innsbruck, Austria
    Arch Gen Psychiatry 62:1305-12. 2005
    ..Dropout rates in randomized clinical trials of antipsychotic drugs have consistently been reported to be high, and the use of a placebo-controlled design is hypothesized to be one of the reasons for this...
  65. ncbi Efficacy and safety of enteric-coated mycophenolate sodium in renal transplant patients with diabetes mellitus: post hoc analyses from three clinical trials
    Frank Pietruck
    Department of Nephrology, University Hospital Essen, Essen, Germany
    Clin Transplant 21:117-25. 2007
    ..Moreover, diabetic patients can apparently be safely converted from MMF to EC-MPS. More data from prospective studies are needed to fully judge the efficacy and safety profile of EC-MPS in the diabetic transplant population...
  66. ncbi Sirolimus eluting stent in the treatment of atherosclerosis coronary artery disease
    M Degertekin
    Department of Interventional Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands
    Minerva Cardioangiol 50:405-18. 2002
    ..As compare with standard coronary stent, a sirolimus-eluting stent shows considerable promise for the prevention of neointimal proliferation, restenosis and associated clinical events...
  67. pmc Effects of patient selection on the applicability of results from a randomised clinical trial (EORTC 10853) investigating breast-conserving therapy for DCIS
    N Bijker
    Department of Radiation Oncology, The Netherlands Cancer Institute Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Br J Cancer 87:615-20. 2002
    ..Selection of patients may explain the differences in outcome of the randomised patients, and those not-entered. Thus, the results of this trial may not be applicable to all patients with ductal carcinoma in situ...
  68. ncbi Rationale and design of a randomized controlled trial to assess the safety and efficacy of cardiac resynchronization therapy in patients with asymptomatic left ventricular dysfunction with previous symptoms or mild heart failure--the REsynchronization reV
    Cecilia Linde
    Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden
    Am Heart J 151:288-94. 2006
    ..The effects of CRT on HF outcomes in patients with asymptomatic left ventricular dysfunction (ALVD) or mild HF remain to be determined...
  69. ncbi Recruiting subjects for acute stroke trials: a meta-analysis
    Jacob S Elkins
    The University of California, San Francisco, CA 94143, USA
    Stroke 37:123-8. 2006
    ..Recruitment rate is a major determinant of the duration, cost, and feasibility of acute stroke trials...
  70. ncbi Electrocardiographic left ventricular hypertrophy in patients with suspected acute cardiac ischemia--its influence on diagnosis, triage, and short-term prognosis: a multicenter study
    G C Larsen
    Center for Cardiovascular Health Services Research, New England Medical Center, Boston, MA 02111
    J Gen Intern Med 9:666-73. 1994
    ..ECG-LVH was poorly recognized (in only 22% of cases) by the physicians in the present study. Better recognition of this common ECG finding may lead to more effective patient management...
  71. ncbi Benefits of bilateral electrical stimulation with the nucleus cochlear implant in adults: 6-month postoperative results
    Roland Laszig
    HNO Klinik Universität Freiburg, HNO Klinik Medizinische Hochschule Hannover, Germany
    Otol Neurotol 25:958-68. 2004
    ....
  72. ncbi Outcomes of surgery for retinal detachment associated with proliferative vitreoretinopathy using perfluoro-n-octane: a multicenter study
    Ingrid U Scott
    Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida 33101, USA
    Am J Ophthalmol 136:454-63. 2003
    ....
  73. ncbi [Multicenter study of the nutritional status of premature infants in neonatal intensive care unit in China: report of 974 cases]
    Dan Hua Wang
    Department of Pediatrics, Peking Union Medical College Hospital, Beijing, China
    Zhonghua Er Ke Za Zhi 47:12-7. 2009
    ..This study was designed to investigate the nutritional support and growth of premature infants who were discharged from 10 tertiary NICUs in different areas in China and evaluate the effects of high risk factors on their growth...
  74. ncbi A controlled study of the relationship between Bordetella pertussis infections and sudden unexpected deaths among German infants
    Ulrich Heininger
    University Hospital for Children and Adolescents, Erlangen, Germany
    Pediatrics 114:e9-15. 2004
    ..This was a prospective, controlled, multicenter study to investigate the relationship between Bordetella pertussis infections and sudden unexpected deaths among German infants...
  75. ncbi Prospective, multicenter study of spinal cord stimulation for relief of chronic back and extremity pain
    K J Burchiel
    Division of Neurosurgery, Oregon Health Sciences University, Portland
    Spine (Phila Pa 1976) 21:2786-94. 1996
    ..Significant improvements in many aspects of the pain condition were measured, and complications were minimal...
  76. ncbi Antimicrobial resistance of Streptococcus pneumoniae isolated from healthy children in day-care centers: results of a multicenter study in Russia
    L S Stratchounski
    Smolensk State Medical Academy, Russia
    Pediatr Infect Dis J 19:196-200. 2000
    ....
  77. ncbi Safety and efficacy of topical diclofenac sodium gel for knee osteoarthritis in elderly and younger patients: pooled data from three randomized, double-blind, parallel-group, placebo-controlled, multicentre trials
    Herbert S B Baraf
    Center for Rheumatology and Bone Research, a division of the Arthritis and Rheumatism Associates, Wheaton, Maryland, USA
    Drugs Aging 28:27-40. 2011
    ..Topical NSAIDs reduce systemic NSAID exposure and may mitigate these risks...
  78. ncbi Patient-reported utilization patterns of fentanyl transdermal system and oxycodone hydrochloride controlled-release among patients with chronic nonmalignant pain
    Stacey J Ackerman
    Covance Health Economics and Outcomes Services Inc, Gaithersburg, MD 20878 5355, USA
    J Manag Care Pharm 9:223-31. 2003
    ..Although use of long-acting opioid analgesics has increased for chronic nonmalignant pain management, little is known about patient-reported utilization patterns...
  79. ncbi Comparison of anterior and posterior instrumentation for correction of adolescent thoracic idiopathic scoliosis
    R R Betz
    Shriners Hospital, Philadelphia, Pennsylvania, USA
    Spine (Phila Pa 1976) 24:225-39. 1999
    ..4) Using the 3.2-mm flexible rod in this study, loss of correction, pseudarthrosis, and rod breakage were unacceptably highe..
  80. ncbi A randomized multicenter study of remifentanil compared with alfentanil, isoflurane, or propofol in anesthetized pediatric patients undergoing elective strabismus surgery
    P J Davis
    Department of Anesthesiology, Children s Hospital of Pittsburgh, University of Pittsburgh, School of Medicine, Pennsylvania, USA peter
    Anesth Analg 84:982-9. 1997
    ..0 microgram.kg-1.min-1 infusion may be twice the 50% effective dose observed in adults. In this study, the relative "overdose" of remifentanil was well tolerated and did not prolong recovery...
  81. ncbi Effectiveness, pharmacokinetics, and safety of a new sustained-release leuprolide acetate 3.75-mg depot formulation for testosterone suppression in patients with prostate cancer: a Phase III, open-label, international multicenter study
    Michael Marberger
    Department of Urology, Vienna University Medical School, Vienna, Austria
    Clin Ther 32:744-57. 2010
    ..A microencapsulated, sustained-release formulation of leuprolide acetate 3.75 mg has been developed...
  82. ncbi Rituximab: a review of its use in chronic lymphocytic leukaemia, low-grade or follicular lymphoma and diffuse large B-cell lymphoma
    Gillian M Keating
    Adis, a Wolters Kluwer Business, Auckland, New Zealand
    Drugs 70:1445-76. 2010
    ..In conclusion, rituximab remains a valuable therapy in patients with CLL, low-grade or follicular lymphoma and diffuse large B-cell lymphoma and, in a variety of treatment settings, represents the standard of care...
  83. ncbi How to improve survival in geriatric peritoneal dialysis patients
    Makoto Hiramatsu
    Department of Nephrology, Okayama Saiseikai General Hospital, Okayama, Japan
    Perit Dial Int 27:S185-9. 2007
    ..In the present study, we reviewed our experience with patients 65 years of age and older at the start of PD and the results from two multicenter studies on PD treatment in elderly patients in Japan.
  84. ncbi Italian multicenter study on complications of laparoscopic myomectomy
    Ornella Sizzi
    Villa Valeria Hospital, Rome, Italy
    J Minim Invasive Gynecol 14:453-62. 2007
    ..To study intraoperative and postoperative complications of laparoscopic myomectomy and patients' characteristics influencing this risk...
  85. ncbi [Gaucher's disease in Tunisia (multicenter study)]
    M Chaabouni
    Service de Pediatrie, hôpital Hédi Chaker, Sfax, Tunisie
    Rev Med Interne 25:104-10. 2004
    ..The purpose of this work is to study the epidemiology of the disease in Tunisia, to highlight the diagnostic and therapeutic difficulties and also to precise our subsequent needs for substitutive medication...
  86. ncbi Dexmedetomidine: a review of its use for sedation in mechanically ventilated patients in an intensive care setting and for procedural sedation
    Sheridan M Hoy
    Adis, a Wolters Kluwer Business, Auckland, New Zealand
    Drugs 71:1481-501. 2011
    ....
  87. ncbi Combination hydrocodone and ibuprofen versus combination codeine and acetaminophen for the treatment of chronic pain
    M Palangio
    Medical Affairs Department, Knoll Pharmaceutical Company, Mount Olive, New Jersey 07828 1234, USA
    Clin Ther 22:879-92. 2000
    ..The objective of this study was to compare the effectiveness of combination hydrocodone 7.5 mg and ibuprofen 200 mg with that of combination codeine 30 mg and acetaminophen 300 mg for the treatment of chronic pain...
  88. ncbi Multicenter study of target-controlled infusion of propofol-sufentanil or sufentanil-midazolam for coronary artery bypass graft surgery. Multicenter Study of Perioperative Ischemia (McSPI) Research Group
    U Jain
    Department of Anesthesia, University of California, San Francisco, USA
    Anesthesiology 85:522-35. 1996
    ..The effects of target-controlled infusions of propofol or sufentanil, supplemented by infusions of sufentanil or midazolam, respectively, were evaluated and compared...
  89. ncbi Laparoscopic splenectomy for idiopathic thrombocytopenic purpura
    Bernard Delaitre
    Department of Surgery, Cochin Hospital, Paris, France
    Surg Laparosc Endosc Percutan Tech 12:412-9. 2002
    ..The long-term results are identical to those of conventional splenectomy, with a better than average success rate in patients that have failed preoperative medical treatment...
  90. ncbi Therapeutic outcomes in 1000 cases of endoscopic submucosal dissection for early gastric neoplasms: Korean ESD Study Group multicenter study
    Ii Kwun Chung
    Department of Internal Medicine, Soonchunhyang University, Cheonan, Korea
    Gastrointest Endosc 69:1228-35. 2009
    ..The drawback of ESD is its technical difficulty, which, consequently, is associated with a higher rate of complication and which requires advanced endoscopic techniques and a long procedure time...
  91. ncbi Radiation prophylaxis for heterotopic ossification about the hip joint--a multicenter study
    M H Seegenschmiedt
    Department of Radiation Oncology, Therapy and Nuclear Medicine, Alfried Krupp Hospital, Essen, Germany
    Int J Radiat Oncol Biol Phys 51:756-65. 2001
    ....
  92. ncbi Comparison between allograft plus demineralized bone matrix versus autograft in anterior cervical fusion. A prospective multicenter study
    H S An
    Department of Orthopaedic Surgery, Medical College of Wisconsin, Milwaukee, USA
    Spine (Phila Pa 1976) 20:2211-6. 1995
    ..For the purpose of solid radiographic fusion, the use of autograft is recommended in anterior cervical surgery until other acceptable osteoinductive materials are developed...
  93. ncbi [Relationship between determining factors for depressive symptoms and for dietary habits in older adults in Mexico]
    José Alberto Avila-Funes
    Centre de recherche sur le vieillissement, Institut Universitaire de Geriatrie de Sherbrooke, Universite de Sherbrooke, Quebec, Canada
    Rev Panam Salud Publica 19:321-30. 2006
    ..To determine the factors that are commonly associated with both the dietary habits of older adults living in the community and depressive symptoms in this group...
  94. ncbi Multidrug-resistant bacteria in hospitalized children: a 5-year multicenter study
    Josette Raymond
    Service de Bacteriologie, Hopital Cochin Saint Vincent de Paul, 27 rue du Faubourg Saint Jacques, 75679 Paris Cedex 14, France
    Pediatrics 119:e798-803. 2007
    ..The objective of this study was to determine the incidence of multidrug-resistant bacteria in hospitalized children...
  95. ncbi ESCRS study of prophylaxis of postoperative endophthalmitis after cataract surgery: Preliminary report of principal results from a European multicenter study
    Peter Barry
    European Society of Cataract and Refractive Surgeons, Dublin, Ireland
    J Cataract Refract Surg 32:407-10. 2006
    ..To report results in the European Society of Cataract & Refractive Surgeons (ESCRS) multicenter study of the prophylaxis of endophthalmitis after cataract surgery...
  96. ncbi [Operative treatment of traumatic fractures of the thorax and lumbar spine. Part II: surgical treatment and radiological findings]
    M Reinhold
    Universitätsklinik für Unfallchirurgie und Sporttraumatologie, Medizinische Universitat Innsbruck, Anichstr 35, 6020 Innsbruck, Osterreich
    Unfallchirurg 112:149-67. 2009
    ..combination), taking into consideration the influence of relevant parameters such as different fracture types, patient age, and the amount of posttraumatic deformity (p=0,34, ANOVA)...
  97. ncbi Multicenter study of pegylated liposomal doxorubicin in patients with cutaneous T-cell lymphoma
    Uwe Wollina
    Department of Dermatology, Hospital Dresden Friedrichstadt, Friedrichstrasse 41, 01067 Dresden, Germany
    Cancer 98:993-1001. 2003
    ..The objective of this study was to evaluate the efficacy and toxicity of single-agent PEG-DOXO as second-line chemotherapy in patients with CTCL...
  98. ncbi Clinical and microbiologic effects of subgingival controlled-release delivery of chlorhexidine chip in the treatment of periodontitis: a multicenter study
    Michele Paolantonio
    Department of Periodontology, School of Dentistry, University G D Annunzio, Chieti, Italy
    J Periodontol 79:271-82. 2008
    ..The aim of this study was to provide further data on the clinical and microbiologic effects of CHX chips when used as an adjunct to SRP...
  99. ncbi Clinical comparison of Healon5 and Healon in phacoemulsification and intraocular lens implantation; Randomized multicenter study
    Tetsuro Oshika
    Department of Ophthalmology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    J Cataract Refract Surg 30:357-62. 2004
    ..3%) and Healon (sodium hyaluronate 1.0%) ophthalmic viscosurgical devices (OVDs)...
  100. ncbi Clinical results of a multicenter study with sulbactam/ampicillin for the treatment of patients with lower respiratory and urinary tract infections
    C De Simone
    Malattie Infettive, , Italy
    J Chemother 3:321-7. 1991
    ..Clinical efficacy: in subjects with lower respiratory tract infections, sulbactam/ampicillin cured 32 patients (72.72%) and ameliorated the clinical status of 8 patients (18.18%); efficacy rate: 90.9%).(ABSTRACT TRUNCATED AT 250 WORDS)..
  101. ncbi Twelve-week, randomized, placebo-controlled, multicenter study of the efficacy and tolerability of budesonide and formoterol in one metered-dose inhaler compared with budesonide alone and formoterol alone in adolescents and adults with asthma
    Jonathan Corren
    Allergy Research Foundation, Los Angeles, CA 90025, USA
    Clin Ther 29:823-43. 2007
    ....

Research Grants76

  1. Hybrid Optical/Doppler Imaging of Ischemia in NEC - a multicenter trial
    David A Benaron; Fiscal Year: 2010
    ..If successful, the health benefit will be large, as it is estimated that treating NEC alone (not including treating its later complications) adds $650 million to the annual health bill. ..
  2. Genetic Epidemiology of Life-Threatening Influenza Infection in Children
    Adrienne Randolph; Fiscal Year: 2009
    ..abstract_text> ..
  3. EEG Synchrony, perinatal risk and outcome: analysis of CHIME data
    PHILIP GEORGE GRIEVE; Fiscal Year: 2010
    ..Recent multicenter studies have shown that adverse outcomes can occur in prematurely born infants with no evidence of neurological ..
  4. Predictive Ability of Gene Expression Signatures In Skin as SSc Biomarkers
    MONIQUE EVANGELINE HINCHCLIFF; Fiscal Year: 2013
    ..To achieve targeted enrollment and to allow Dr. Hinchcliff to gain experience conducting multicenter studies, patients will be recruited from three large academic scleroderma programs...
  5. Phenotypes of diabetic kidney disease and the relationship to retinal pathology
    Amy Mottl; Fiscal Year: 2013
    ..This will form the basis for an R01 which will extend these robust techniques to a larger cohort and provide definitive data regarding the phenotypes of diabetic complications of the kidney and eye and their relationship to each other. ..
  6. Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units Network
    Edward K Chien; Fiscal Year: 2013
    ..Our investigators have strong backgrounds in clinical and multicenter studies, those involving neonatal and long term infant follow-up, and in the above listed network studies...
  7. Estrogen signaling in portopulmonary hypertension
    Steven M Kawut; Fiscal Year: 2013
    ..Finally, downregulation of CEPs by fulvestrant would identify ERalpha blockade as another approach. If these hypotheses are incorrect, we could use the genetic and biomarker data to examine alternative hypotheses. ..
  8. Preventive Approach to Congenital Heart Block with Hydroxychloroquine (PATCH)
    JILL PAMELA BUYON; Fiscal Year: 2013
    ..Despite the attempt of large multicenter studies to forestall disease by serial in utero monitoring, irreversibe block and extensive myocardial injury have ..
  9. Quantification and Characterization of Coronary Atherosclerotic Plaque by CT
    Armin A Zadeh; Fiscal Year: 2013
    ..Zadeh's transition to an independent investigator with focus on patient-oriented research. ..
  10. NICHD Cooperative Multicenter Neonatal Research Network
    Abbot R Laptook; Fiscal Year: 2013
    ..a well organized research team that includes Physicians with broad expertise in neonatal morbidities and multicenter studies, outstanding Research Nurses, and excellent follow-up to assess early childhood neurodevelopment...
  11. PHASE II TRIAL OF SLEEP APNEA TREATMENT TO REDUCE CARDIOVASCULAR MORBIDITY
    SUSAN S REDLINE; Fiscal Year: 2010
    ..collaborative research team (Sleep Heart Health Study investigators) experienced with the conduct of multicenter studies of OSA, expanding the team to include experienced cardiovascular translational and clinical trials ..
  12. The Effect of Low Frequency STN DBS on Sleep and Vigilance in PD Patients
    AMY WILLIS AMARA; Fiscal Year: 2013
    ..abstract_text> ..
  13. Device to Improve Treatment of Colorectal Cancer Using O2 Dependent Phosphorescen
    JASON MATTHEW ZAND; Fiscal Year: 2010
    ..The proposed device could significantly reduce patient suffering, while saving $2 billion dollars annually in excess healthcare costs. ..
  14. Pittsburgh Pelvic Floor Research Program
    Halina M Zyczynski; Fiscal Year: 2013
    ..Our site has a longstanding track record of successful contribution to multicenter studies of urinary and fecal incontinence, and pelvic organ prolapse...
  15. Anti-viral and antileukemic T-cell therapy as prophylaxis after HSCT
    Helen E Heslop; Fiscal Year: 2013
    ..therapies with cell and gene therapy products and has successfully sponsored and implemented over 40 cell and gene therapy studies under more than 25 investigator initiated INDs, including Phase II multicenter studies .
  16. Research on the Scope and Causes of Stillbirth in the US
    Carol Hogue; Fiscal Year: 2009
    ..history of successful funded research, publications in relevant areas, and active involvement with other multicenter studies and multicenter Networks. Dr. B...
  17. Solid Organ Transplantation in HIV: Multi-Site Study
    Peter G Stock; Fiscal Year: 2010
    ....
  18. ENVIRONMENTAL TOBACCO SMOKE EXPOSURE AMONG CHILDREN HOSPITALIZED WITH PNEUMONIA
    Derek Williams; Fiscal Year: 2010
    ....
  19. A Four-arm Prospective, Multicenter Study to Assess the Clinical Efficacy, Effect
    Daniel J Sexton; Fiscal Year: 2013
    ....
  20. Pseudomonas aeruginosa Adaptation During Early CF Airway Infection and Treatment
    Lucas R Hoffman; Fiscal Year: 2012
    ..epidemiologists that will make use of the unique resources generated from two large, interrelated, ongoing multicenter studies of CF microbiology, known as the Early Antipseudomonal Therapy in Cystic Fibrosis studies (EPIC)...
  21. Clinical evaluation of a bioadhesive gel for oral cancer chemoprevention.
    Susan R Mallery; Fiscal Year: 2010
    ....
  22. Determining Optimum Medical Therapy for ITP
    JAMES BRUCE BUSSEL; Fiscal Year: 2013
    ....
  23. NRSA TRAINING: PSYCHIATRIC-MEDICAL COMORBIDITY IN AGING
    David W Oslin; Fiscal Year: 2010
    ..as investigators able to develop an independent line of investigation in the context of larger scale, multicenter studies. It will consider applicants with MD and PhD degrees who are committed to careers in intervention research...
  24. Preterm Birth in Nulliparous Women: An Understudied Population at Great Risk
    Hyagriv N Simhan; Fiscal Year: 2013
    ..Our site has been a long-standing track record of successful contribution to single and multicenter studies of adverse pregnancy outcomes for more than 20 years...
  25. Glycemic Reduction Approaches for Treating Diabetes: An Effectiveness Study
    David M Nathan; Fiscal Year: 2011
    ..Since type 2 diabetes is now epidemic, affecting more than 20 million people in the US, comparing and selecting the most effective treatment methods will have a major public health impact. ..
  26. Prospective Cohort Study of Severe Bronchiolitis and Risk of Recurrent Wheezing
    Carlos A Camargo; Fiscal Year: 2013
    ..The research team is comprised of NIH-funded researchers who have led many multicenter studies in this area...
  27. Biomarkers of the risk for post-traumatic osteoarthritis
    James A Martin; Fiscal Year: 2010
    ..of the biomarkers identified in this small scale exploratory study will be further investigated in future multicenter studies with larger numbers of subjects and longer term follow ups...
  28. Intragraft expression to Predict Future GFR Decline in Kidney Transplantation
    Mark D Stegall; Fiscal Year: 2013
    ..Gene expression appears to identify kidneys that will lose function later, sheds light on the causes of kidney transplant damage and may lead to new therapy that will help transplants last longer. ..
  29. Genetic and Environmental Risk Factors for PSP
    Irene Litvan; Fiscal Year: 2010
    ..The use of the NINDS cell repository for genetic banking will also allow DNA sample sharing with other investigators. ..
  30. Development and Adaptive Behavior of Young Children with Hearing Loss
    Carren Stika; Fiscal Year: 2012
    ..abstract_text> ..
  31. Prospective Multicenter Study of Bronchiolitis Admissions: Etiology & Disposition
    Carlos A Camargo; Fiscal Year: 2010
    ..emnet-usa.org), a clinical research network that has completed >20 multicenter studies focusing on respiratory emergencies and public health...
  32. MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS
    Michele Walsh; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE (See instructions): To improve the health of neonates one must conduct large multicenter studies as the population at any single center is not sufficiently large to allow adequate sample sizes for ..
  33. 4/4-Optimizing Treatment of Complicated Grief
    Sidney Zisook; Fiscal Year: 2013
    ..We will explore mediator and moderator hypotheses to answer questions about how these treatments work and who might benefit most from each approach. Answers to these questions have important public health significance. ..
  34. 2/4-Optimizing Treatment of Complicated Grief
    Naomi M Simon; Fiscal Year: 2013
    ..We will explore mediator and moderator hypotheses to answer questions about how these treatments work and who might benefit most from each approach. Answers to these questions have important public health significance. ..
  35. 1/4-Optimizing Treatment for Complicated Grief
    M Katherine Shear; Fiscal Year: 2012
    ..We will explore mediator and moderator hypotheses to answer questions about how these treatments work and who might benefit most from each approach. Answers to these questions have important public health significance. ..
  36. Treatment of Pulmonary Edema in Organ Donors
    Lorraine B Ware; Fiscal Year: 2012
    ..The proposed studies will test a widely used, safe, inhaled therapy to determine whether donor lung function can be improved. ..
  37. Novel Therapies for Alcoholic Hepatitis
    Gyongyi Szabo; Fiscal Year: 2013
    ..5 years of the grant.A biorepository of the collected clinical data and patient samples will also be established that will be an important national resource for transforming clinical practice for the treatment of AH. ..
  38. Green Housing Study: Measures of Housing Factors and Pediatric Respiratory Health
    Tiina Reponen; Fiscal Year: 2013
    ..This elucidation then could inform policy about which green components should be implemented without regard to locality, and which components should be modified under certain circumstances (e.g., region or housing type). ..
  39. Effect of Positive Airway Pressure on Reducing Airway Reactivity in Patients wit*
    Robert A Wise; Fiscal Year: 2013
    ..If CPAP at night is effective, it will represent an entirely new approach to treating asthma. (End of Abstract) ..
  40. Continuation of the NIDDK Gastroparesis Consortium
    Irene Sarosiek; Fiscal Year: 2013
    ..outcome in GP patients by further in-depth analysis of GpR clinical data and biosamples;# 3: To conduct new multicenter studies of gastroparesis investigating the etiology, pathogenesis, diagnosis, and treatment options...
  41. Determination of Skeletal Muscle Mass by Creatine Dilution
    Peggy Mannen Cawthon; Fiscal Year: 2013
    ..This simple test could be used clinically as an alternative to DXA to identify men at risk of physical decline and to refine sarcopenia definitions. ..
  42. PROPRANOLOL AS ANTI-ADHESIVE THERAPY IN SCD
    Laura Decastro; Fiscal Year: 2011
    ..Our preliminary data suggest that propranolol, an inexpensive and widely available drug, might be safe and useful for this purpose. Thus, we propose to test this hypothesis in a Phase II single center clinical study. ..
  43. 18F-Fluoroestradiol PET/CT guided fulvestrant therapy for patients with recurrent
    Stephen Chia; Fiscal Year: 2010
    ..Success would benefit breast cancer patients by allowing physicians to make better decisions about who should be treated with fulvestrant, and who may respond better to alternative treatments. ..
  44. Bone Marrow Transplant Clinical Network
    Edward A Stadtmauer; Fiscal Year: 2010
    ..a definitive way requires the existence of a network committed to development and implementation of large, multicenter studies. Under RFA HL-01-004, the National Heart, Lung, and Blood Institute (NHLBI) and the National Cancer ..
  45. Clonal evolution
    Brian J Reid; Fiscal Year: 2011
    ..Finally, Project 1 will develop clinically compatible DNA biomarker platforms for our validated markers so that they can be used in other centers and multicenter studies.
  46. MR-guided focused ultrasound system
    Fergus V Coakley; Fiscal Year: 2010
    ..This grant will generate or sustain over 25 jobs, and uses a technology that creates little or no biohazardous waste and does not use ionizing radiation. ..
  47. Severe Enteric Disease: Pathogenesis and Response
    James B Kaper; Fiscal Year: 2013
    ....
  48. Treating Older Patients with Major Depression and Severe COPD
    George S Alexopoulos; Fiscal Year: 2012
    ....
  49. Molecular and clinical characterization of ion channelopathies
    Qing Ke; Fiscal Year: 2010
    ..Dr. Ke will gain experience and expertise in the design of studies of patients with neuromuscular Channelopathies in order to be able to participates international multicenter studies in the future.
  50. Temple University Gastroparesis Clinical Center
    HENRY PAUL PARKMAN; Fiscal Year: 2013
    ..Third, to conduct new multicenter studies of gastroparesis investigating the etiology, pathogenesis, diagnosis, and treatment...
  51. A pilot study of statin therapy and risk of malignant glioma
    ROSE KAMYEE LAI; Fiscal Year: 2012
    ..for funding to initiate population-based investigations and to collaborate with other epidemiologists in multicenter studies. My long term goal is to independently obtain NIH funding to examine the genetic susceptibility of brain ..
  52. Effect of treatment on outcome after TBI in children and adolescents
    Frederick P Rivara; Fiscal Year: 2013
    ..The study team represents a uniquely interdisciplinary group of very experienced investigators who are capable of carrying out a rigorous study to provide information to inform future research, care and policy. ..
  53. VIPS: Vascular Effects of Infection in Pediatric Stroke
    Heather J Fullerton; Fiscal Year: 2013
    ..It will also determine causes of recurrence, a crucial step towards developing ways to prevent repeated strokes in children. ..
  54. Quantitative measurement of T1D risk through molecular signature analysis
    MARTIN JOHN HESSNER; Fiscal Year: 2013
    ..2) Define disease-specificity of the T1D-signature. ..
  55. Data Coordinating Center for Autism & Other Disabilities
    PHILIP REED; Fiscal Year: 2009
    ..Several consultants from Michigan Department of Community Health, Research Triangle Institute, and the University of North Carolina -Chapel Hill have agreed to to provide their expertise on various aspects of this project. ..
  56. A Combination Intervention Package for Isoniazid Preventive Therapy in Ethiopia
    ANDREA ALLOCCO HOWARD; Fiscal Year: 2013
    ..proposal includes a diversity of expertise and a wealth of experience in large, collaborative, prospective, multicenter studies in resource-limited countries, particularly in sub- Saharan Africa...
  57. Columbia University-Southern African AIDS International Training/Research Program
    Quarraisha Abdool Karim; Fiscal Year: 2013
    ..training critical to the efforts of South African AIDS research to transition from the current reliance on multicenter studies to a more sustainable balanced portfolio with increased levels of investigator-initiated research...
  58. Vascular Metabolic Memory in Type 2 Diabetes
    Peter D Reaven; Fiscal Year: 2013
    ....
  59. VALIDATION OF HEARTSBREATH TEST FOR HEART TRANSPLANT REJECTION
    Michael Phillips; Fiscal Year: 2012
    ..We will validate the Heartsbreath test as a predictor of Grade 2R heart transplant rejection in order to fulfill Medicare requirements for reimbursement. ..
  60. A BREATH TEST FOR LUNG CANCER
    Michael Phillips; Fiscal Year: 2009
    ..Early, safe and cost-effective detection of lung cancer could potentially reduce the number of lives lost to the disease. ..
  61. Pathology of the FSGS Kidney
    Agnes B Fogo; Fiscal Year: 2010
    ..These approaches could ultimately identify novel therapeutic targets in FSGS. ..
  62. A Device to Reduce Anastomotic Failure in the Treatment of Colorectal Cancer
    JASON ZAND; Fiscal Year: 2009
    ..The proposed device could significantly reduce patient suffering, while saving $2 billion dollars annually in excess healthcare costs. ..
  63. THE UNSUSPECTED SMALL STONE STUDY (USSS)
    James DiSario; Fiscal Year: 2000
    ..The study group and systems developed in this proposal will be used for future multicenter projects on gallstone disease. ..
  64. N3 FATTY ACIDS EFFECT ON SICKLE CELL PAIN EPISODES
    James Eckman; Fiscal Year: 2001
    ..abstract_text> ..
  65. PET IN HYPERKINETIC DISORDERS--A MULTICENTER STUDY
    David Eidelberg; Fiscal Year: 2001
    ..This approach may have great utility in evaluating new interventions for the treatment of the hyperkinetic movement disorders. ..
  66. MECHANISMS OF ACTION IN DPP INTERVENTIONS
    Abbas Kitabchi; Fiscal Year: 2001
    ....
  67. Familial Aggregation of Barrett's Esophagus
    Amitabh Chak; Fiscal Year: 2003
    ..The overall aim of this pilot proposal is to develop methodologies that will facilitate future multicenter studies aimed at assessing the familial aggregation of Barrett's esophagus and esophageal adenocarcinoma...
  68. CARDIAC AUTONOMIC CONTROL IN CHILDREN OF HIV+ MOTHERS
    Steven Lipshultz; Fiscal Year: 1993
    ....
  69. Depression in Alzheimer's Disease-II
    Curtis Meinert; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  70. Depression in Alzheimer's Disease Study-2(DIADS-2)
    Daniel Weintraub; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  71. Depression in Alzheimer's Disease Study 2 (DIADS-2)
    Constantine Lyketsos; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  72. Depressoin in Alzheimer's Disease Study-2 (DIADS-2)
    Jacobo Mintzer; Fiscal Year: 2007
    ..abstract_text> ..
  73. Depression in Alzheimer's Disease Study 2 (DIADS-2)
    Anton Porsteinsson; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  74. Depression in Alzheimer's Disease Study 2 (DIADS-2)
    Lon Schneider; Fiscal Year: 2007
    ..unreadable] [unreadable]..