prosthesis failure

Summary

Summary: Malfunction of implantation shunts, valves, etc., and prosthesis loosening, migration, and breaking.

Top Publications

  1. ncbi Guidelines for standardization of radiostereometry (RSA) of implants
    Edward R Valstar
    Department of Orthopaedics, Leiden University Medical Center, The Netherlands
    Acta Orthop 76:563-72. 2005
  2. ncbi Infection burden for hip and knee arthroplasty in the United States
    Steven M Kurtz
    Exponent Inc, Philadelphia, Pennsylvania 19104, USA
    J Arthroplasty 23:984-91. 2008
  3. pmc Uncemented and cemented primary total hip arthroplasty in the Swedish Hip Arthroplasty Register
    Nils P Hailer
    Department of Orthopaedics, Institute of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Acta Orthop 81:34-41. 2010
  4. ncbi The Norwegian Arthroplasty Register: 11 years and 73,000 arthroplasties
    L I Havelin
    Department of Orthopaedic Surgery, Haukeland University Hospital, Norway
    Acta Orthop Scand 71:337-53. 2000
  5. ncbi More re-operations after uncemented than cemented hemiarthroplasty used in the treatment of displaced fractures of the femoral neck: an observational study of 11,116 hemiarthroplasties from a national register
    J E Gjertsen
    Haukeland University Hospital, Department of Orthopaedic Surgery, N 5021 Bergen, Norway
    J Bone Joint Surg Br 94:1113-9. 2012
  6. pmc Early migration characteristics of a hydroxyapatite-coated femoral stem: an RSA study
    David Campbell
    Orthopaedic Unit, Repatriation General Hospital, Adelaide, South Australia, Australia
    Int Orthop 35:483-8. 2011
  7. pmc Notes on the use and interpretation of radiostereometric analysis
    Brian Derbyshire
    Centre for Hip Surgery, Wrightington Hospital, Appley Bridge, UK
    Acta Orthop 80:124-30. 2009
  8. ncbi Early failure of metal-on-metal bearings in hip resurfacing and large-diameter total hip replacement: A consequence of excess wear
    D J Langton
    North Tees and Hartlepool NHS Trust, Stockton on Tees and Centre for Rehabilitation, Newcastle University, Newcastle upon Tyne, England
    J Bone Joint Surg Br 92:38-46. 2010
  9. ncbi Accelerating failure rate of the ASR total hip replacement
    D J Langton
    Northern Deanery, Goldcrest Way, Newcastle upon Tyne NE15 8NY, UK
    J Bone Joint Surg Br 93:1011-6. 2011
  10. ncbi Five-year results of the ASR XL Acetabular System and the ASR Hip Resurfacing System: an analysis from the Australian Orthopaedic Association National Joint Replacement Registry
    Richard N de Steiger
    Australian Orthopaedic Association National Joint Replacement Registry, Discipline of Public Health, University of Adelaide, Adelaide, SA, Australia
    J Bone Joint Surg Am 93:2287-93. 2011

Detail Information

Publications303 found, 100 shown here

  1. ncbi Guidelines for standardization of radiostereometry (RSA) of implants
    Edward R Valstar
    Department of Orthopaedics, Leiden University Medical Center, The Netherlands
    Acta Orthop 76:563-72. 2005
    ..Such a protocol-also including other recognized clinical outcome parameters-will reduce the risk of implanting potentially inferior prostheses on a large scale...
  2. ncbi Infection burden for hip and knee arthroplasty in the United States
    Steven M Kurtz
    Exponent Inc, Philadelphia, Pennsylvania 19104, USA
    J Arthroplasty 23:984-91. 2008
    ..26% for knees compared to rural (0.61% for hips and 0.69% for knees) and urban-teaching hospitals (0.73% for hips and 0.77% for knees). We found an increasing number of joint arthroplasties being diagnosed with periprosthetic infection...
  3. pmc Uncemented and cemented primary total hip arthroplasty in the Swedish Hip Arthroplasty Register
    Nils P Hailer
    Department of Orthopaedics, Institute of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Acta Orthop 81:34-41. 2010
    ..We therefore analyzed implant survival of cemented and uncemented THA, and whether the modes of failure differ between the two methods of fixation...
  4. ncbi The Norwegian Arthroplasty Register: 11 years and 73,000 arthroplasties
    L I Havelin
    Department of Orthopaedic Surgery, Haukeland University Hospital, Norway
    Acta Orthop Scand 71:337-53. 2000
    ..Since the practice of using undocumented implants has not changed, the register will continue to survey these implants. We plan to assess the mid- and long-term results of implants that have so far had good short-term results...
  5. ncbi More re-operations after uncemented than cemented hemiarthroplasty used in the treatment of displaced fractures of the femoral neck: an observational study of 11,116 hemiarthroplasties from a national register
    J E Gjertsen
    Haukeland University Hospital, Department of Orthopaedic Surgery, N 5021 Bergen, Norway
    J Bone Joint Surg Br 94:1113-9. 2012
    ..However, in a time-dependent analysis, the HRR for re-operation in both groups increased as follow-up increased. This study showed that the risk for revision was higher for uncemented than for cemented hemiarthroplasties...
  6. pmc Early migration characteristics of a hydroxyapatite-coated femoral stem: an RSA study
    David Campbell
    Orthopaedic Unit, Repatriation General Hospital, Adelaide, South Australia, Australia
    Int Orthop 35:483-8. 2011
    ..The results from this study can be compared with those from novel cementless stem designs to help predict the long-term outcome one may expect from new cementless stem designs...
  7. pmc Notes on the use and interpretation of radiostereometric analysis
    Brian Derbyshire
    Centre for Hip Surgery, Wrightington Hospital, Appley Bridge, UK
    Acta Orthop 80:124-30. 2009
    ..Alternatives are proposed, and a statistical analysis is presented, from which a sample size of 50 is recommended for screening of newly introduced prostheses...
  8. ncbi Early failure of metal-on-metal bearings in hip resurfacing and large-diameter total hip replacement: A consequence of excess wear
    D J Langton
    North Tees and Hartlepool NHS Trust, Stockton on Tees and Centre for Rehabilitation, Newcastle University, Newcastle upon Tyne, England
    J Bone Joint Surg Br 92:38-46. 2010
    ..Surgeons must consider implant design, expected component size and acetabular component positioning in order to reduce early failures when performing large-bearing metal-on-metal hip resurfacing and replacement...
  9. ncbi Accelerating failure rate of the ASR total hip replacement
    D J Langton
    Northern Deanery, Goldcrest Way, Newcastle upon Tyne NE15 8NY, UK
    J Bone Joint Surg Br 93:1011-6. 2011
    ..Our results suggest that wear at the modular junction is an important factor in the development of adverse tissue reactions after implantation of a large-diameter MoM THR...
  10. ncbi Five-year results of the ASR XL Acetabular System and the ASR Hip Resurfacing System: an analysis from the Australian Orthopaedic Association National Joint Replacement Registry
    Richard N de Steiger
    Australian Orthopaedic Association National Joint Replacement Registry, Discipline of Public Health, University of Adelaide, Adelaide, SA, Australia
    J Bone Joint Surg Am 93:2287-93. 2011
    ..This report summarizes an analysis by the Australian Orthopaedic Association National Joint Replacement Registry (AOANJRR) of the outcome of arthroplasties involving the ASR prostheses...
  11. ncbi The role of macrophages in osteolysis of total joint replacement
    Eileen Ingham
    School of Biochemistry and Molecular Biology, Institute of Medical and Biological Engineering, Division of Microbiology, University of Leeds, Leeds LS2 9JT, UK
    Biomaterials 26:1271-86. 2005
    ..Firstly, as the major cell in host defence responding to UHMWPE particles via the production of cytokines and secondly as precursors for the osteoclasts responsible for the ensuing bone resorption...
  12. ncbi Hemiarthroplasty of the hip with and without cement: a randomized clinical trial
    Fraser Taylor
    Auckland City Hospital, Private Bag 92 024, Auckland Mail Centre, Auckland 1142, New Zealand
    J Bone Joint Surg Am 94:577-83. 2012
    ..The primary hypothesis of this study was that use of cement would provide better visual analog pain scores following this procedure in an elderly patient population...
  13. pmc Inferior outcome after hip resurfacing arthroplasty than after conventional arthroplasty. Evidence from the Nordic Arthroplasty Register Association (NARA) database, 1995 to 2007
    Per Erik Johanson
    Department of Orthopedics, Sahlgrenska University Hospital, University of Gothenburg, Sweden
    Acta Orthop 81:535-41. 2010
    ..We therefore determined the outcome of HRA in the NARA database, which is common to all 3 countries, and compared it to the outcome of conventional total hip arthroplasty (THA)...
  14. ncbi Birmingham hip resurfacing: a minimum follow-up of ten years
    R B C Treacy
    Royal Orthopaedic Hospital, Bristol Road South, Northfield, Birmingham B31 2AP, UK
    J Bone Joint Surg Br 93:27-33. 2011
    ....
  15. pmc Mid-term results of 155 patients treated with a collum femoris preserving (CFP) short stem prosthesis
    Daniel Briem
    Endoclinic Hamburg, Hamburg, Germany
    Int Orthop 35:655-60. 2011
    ..With regard to outcome, survivorship and complication rate, the medium-term results of the CFP prosthesis are promising...
  16. pmc Increasing risk of revision due to deep infection after hip arthroplasty
    Håvard Dale
    The Norwegian Arthroplasty Register, Department of Orthopaedic Surgery, Haukeland University Hospital, Bergen, Norway
    Acta Orthop 80:639-45. 2009
    ..We assessed the risk of revision due to deep infection for primary THAs reported to the Norwegian Arthroplasty Register (NAR) over the period 1987-2007...
  17. ncbi Antibiotic prophylaxis in total hip arthroplasty: effects of antibiotic prophylaxis systemically and in bone cement on the revision rate of 22,170 primary hip replacements followed 0-14 years in the Norwegian Arthroplasty Register
    Lars B Engesaeter
    The Norwegian Arthroplasty Register, Department of Orthopaedic Surgery, Haukeland University Hospital, Bergen, Norway
    Acta Orthop Scand 74:644-51. 2003
    ..This observational study shows that the best results were recorded when antibiotic prophylaxis was given both systemically and in the bone cement, and if the systemic antibiotic was given 4 times on the day of surgery...
  18. ncbi Meta-analysis of randomized trials comparing the patency of covered and uncovered self-expandable metal stents for palliation of distal malignant bile duct obstruction
    Atif Saleem
    Department of Internal Medicine, Mayo Clinic, College of Medicine, Rochester, Minnesota, USA
    Gastrointest Endosc 74:321-327.e1-3. 2011
    ..Self-expandable metal stents (SEMSs) are used for palliation of malignant biliary obstruction...
  19. ncbi The seven-year wear of highly cross-linked polyethylene in total hip arthroplasty: a double-blind, randomized controlled trial using radiostereometric analysis
    Geraint E R Thomas
    Biomedical Research Unit, Headington, Oxford OX3 7LD, United Kingdom
    J Bone Joint Surg Am 93:716-22. 2011
    ....
  20. pmc Late complications and survival of endoprosthetic reconstruction after resection of bone tumors
    Ahmad Shehadeh
    Washington Cancer Institute at Washington Hospital Center, Washington, DC, USA
    Clin Orthop Relat Res 468:2885-95. 2010
    ..While complications following massive endoprosthetic reconstruction have been previously described, the incidence and effects of these complications over extended periods of time have not been well characterized in large series...
  21. ncbi Orthopedic wear debris mediated inflammatory osteolysis is mediated in part by NALP3 inflammasome activation
    Lyndsey Burton
    Hospital for Special Surgery, 535 East 70th Street, New York, New York 10021, USA
    J Orthop Res 31:73-80. 2013
    ..Our findings identify the NALP3 inflammasome as a critical mediator of orthopedic wear-induced osteolysis and as a viable therapeutic target for the treatment of periprosthetic osteolysis...
  22. pmc Elevation of circulating HLA DR(+) CD8(+) T-cells and correlation with chromium and cobalt concentrations 6 years after metal-on-metal hip arthroplasty
    Nils P Hailer
    Department of Orthopedics, Institute of Surgical Sciences, Uppsala University Hospital, Sweden
    Acta Orthop 82:6-12. 2011
    ..We hypothesized that changes in lymphocyte subpopulations would be associated with elevated metal ion concentrations...
  23. ncbi Failure rates of metal-on-metal hip resurfacings: analysis of data from the National Joint Registry for England and Wales
    Alison J Smith
    Orthopaedic Surgery, Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol, Bristol, UK
    Lancet 380:1759-66. 2012
    ..We assessed the survival of different sizes of metal-on-metal resurfacing in men and women, and compared this survival with those for conventional stemmed THRs...
  24. pmc Corrosion at the cone/taper interface leads to failure of large-diameter metal-on-metal total hip arthroplasties
    Heiko Meyer
    Department of Orthopaedics, Otto von Guericke University, Leipziger Str 44, 39108 Magdeburg, Germany
    Clin Orthop Relat Res 470:3101-8. 2012
    ..Metal-on-metal (MoM) THAs have reduced wear rates compared with metal-on-polyethylene. However, elevated serum metal ion levels and pseudotumors have been reported in large MoM articulations...
  25. pmc The John Charnley Award: Metal-on-metal hip resurfacing versus large-diameter head metal-on-metal total hip arthroplasty: a randomized clinical trial
    Donald S Garbuz
    Division of Lower Limb Reconstruction and Oncology, Department of Orthopaedics, University of British Columbia, Room 3114, 910 West 10th Avenue, Vancouver, BC, V5Z 4E3, Canada
    Clin Orthop Relat Res 468:318-25. 2010
    ..6-fold higher than in the resurfacing arm. Due to these excessively high metal ion levels, the authors recommend against further use of this particular large-head total hip arthroplasty...
  26. pmc Hip resurfacing arthroplasty: short-term survivorship of 4,401 hips from the Finnish Arthroplasty Register
    Matti Seppänen
    Department of Orthopaedics and Traumatology, Turku University Hospital, Turku, Finland
    Acta Orthop 83:207-13. 2012
    ..We analyzed the short-term survival of 4,401 HRAs in the Finnish Arthroplasty Register...
  27. pmc Arthroplasty options in femoral-neck fracture: answers from the national registries
    Arun Kannan
    University of Minnesota, Minneapolis, MN, USA
    Int Orthop 36:1-8. 2012
    ..Clinical trials and systematic reviews of such trials have not provided a convincing answer to this question...
  28. ncbi Total hip arthroplasty: to cement or not to cement the acetabular socket? A critical review of the literature
    N D Clement
    Department of Orthopaedics and Trauma, Royal Infirmary of Edinburgh, Little France, Edinburgh, UK
    Arch Orthop Trauma Surg 132:411-27. 2012
    ....
  29. pmc A modular cementless stem vs. cemented long-stem prostheses in revision surgery of the hip: a population-based study from the Swedish Hip Arthroplasty Register
    Rudiger J Weiss
    Department of Molecular Medicine and Surgery, Section of Orthopaedics and Sports Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Acta Orthop 82:136-42. 2011
    ..In this paper, we review risk factors for the outcome of the Link MP stem and report implant survival compared to conventional cemented long-stem hip revision arthroplasties...
  30. ncbi Patellar resurfacing in total knee arthroplasty for osteoarthritis: a meta-analysis
    Yonghui Fu
    Department of Orthopedic Surgery, Shengjing Hospital, China Medical University, No 36, Sanhao Street, Heping District, Shenyang City, People s Republic of China
    Knee Surg Sports Traumatol Arthrosc 19:1460-6. 2011
    ..The aim of this study was to determine the advantages and disadvantages of patellar resurfacing during total knee arthroplasty for osteoarthritis through an evaluation of the current literature...
  31. ncbi Correlation between inclination of the acetabular component and metal ion levels in metal-on-metal hip resurfacing replacement
    R de Haan
    University Hospital Brussels, Laarbeeklaan 101, 1090 Brussels, Belgium
    J Bone Joint Surg Br 90:1291-7. 2008
    ..This is probably due to a greater risk of edge-loading...
  32. pmc What works best, a cemented or cementless primary total hip arthroplasty?: minimum 17-year followup of a randomized controlled trial
    Kristoff Corten
    London Health Sciences Centre, University Campus, 339 Windermere Road, London, ON N6A 5A5, Canada
    Clin Orthop Relat Res 469:209-17. 2011
    ..Total hip arthroplasty (THA) has been associated with high survival rates, but debate remains concerning the best fixation mode of THA...
  33. ncbi Fixed or loose? Dichotomy in RSA data for cemented cups
    Per Aspenberg
    Department of Orthopaedics, IKE, Faculty of Health Sciences, Linkoping, Sweden
    Acta Orthop 79:467-73. 2008
    ..We present an exploratory evaluation of such a dichotomy using a mixture distribution algorithm...
  34. ncbi Birmingham hip resurfacing: the prevalence of failure
    A D Carrothers
    Robert Jones and Agnes Hunt Orthopaedic Hospital, Gobowen, Oswestry SY10 7AG, UK
    J Bone Joint Surg Br 92:1344-50. 2010
    ..5 years, 0.02 to 11.0). There was a significantly shorter time to failure in men (mean 2.1 years, 0.4 to 8.7) compared with women (mean 3.6 years, 0.003 to 11.0) (p < 0.001)...
  35. ncbi What is the benefit of introducing new hip and knee prostheses?
    Rajan Anand
    Discipline of Public Health, University of Adelaide, MDP DX650, 511 Australia SA 5005
    J Bone Joint Surg Am 93:51-4. 2011
    ..The underlying purpose of the introduction of new devices is to improve patient outcomes. This study was undertaken to determine how many new prostheses were associated with improved patient outcomes...
  36. ncbi The effect of hydroxyapatite on the micromotion of total knee prostheses. A prospective, randomized, double-blind study
    R G Nelissen
    Department of Orthopaedic Surgery, Leiden University Medical Centre, The Netherlands
    J Bone Joint Surg Am 80:1665-72. 1998
    ..Therefore, hydroxyapatite, a biological mediator, may be necessary for the adequate fixation of tibial components when cement is not used...
  37. pmc Thirty years of experience with alumina-on-alumina bearings in total hip arthroplasty
    Didier Hannouche
    Department of Orthopaedic Surgery and Traumatology, AP HP, Hôpital Lariboisière University Paris 7, 2 rue Ambroise Pare, 75010 Paris, France
    Int Orthop 35:207-13. 2011
    ..4% at ten years. However, concern remains over ceramic liner fracture and squeaking, which has been noted recently with increasing prevalence. This review will discuss the current knowledge on the use of alumina-on-alumina bearings...
  38. ncbi Randomised controlled trial comparing early migration of two collarless polished cemented stems using radiostereometric analysis
    R W McCalden
    London Health Sciences Centre, University of Western Ontario, 339 Windermere Road, London, Ontario, Canada N6A 5A5
    J Bone Joint Surg Br 92:935-40. 2010
    ..The subtle differences in designs may explain the different patterns of migration. Comparable migration with the Exeter stem suggests that the CPCS design will perform well in the long term...
  39. ncbi Long-term results of the ABG-1 hydroxyapatite coated total hip arthroplasty: analysis of 111 cases with a minimum follow-up of 10 years
    R Bidar
    Department of Orthopaedics and Traumatology, Carémeau Teaching Hospital Center, place du Pr Robert Debré, 30029 Nimes Cedex 9, France
    Orthop Traumatol Surg Res 95:579-87. 2009
    ....
  40. ncbi Survival of metal-on-metal hip resurfacing arthroplasty: a systematic review of the literature
    W van der Weegen
    Department of Orthopaedic Surgery, St Anna Hospital, Geldrop, The Netherlands
    J Bone Joint Surg Br 93:298-306. 2011
    ..None of the hip resurfacing arthroplasty implants used to date met the full ten-year NICE benchmark of survival. A total of 13 studies showed satisfactory survival compared with the three-year NICE benchmark...
  41. pmc Risk factors in cutout of sliding hip screw in intertrochanteric fractures: an evaluation of 937 patients
    Kuang Kai Hsueh
    Departments of Orthopaedics and Traumatology, Taipei Veterans General Hospital, National Yang Ming University, Taiwan, Republic of China corrected
    Int Orthop 34:1273-6. 2010
    ..In order to decrease the risk of lag-screw cutout, it is important to ensure good fracture reduction and to place the lag screw in either the middle/middle or inferior/middle position with appropriate TAD...
  42. ncbi Ceramic liner fracture after cementless alumina-on-alumina total hip arthroplasty
    Yong Chan Ha
    Department of Orthopaedic Surgery, Gyeongsang National University Colleg of Medicine, Chinju, South Korea
    Clin Orthop Relat Res 458:106-10. 2007
    ..Early ceramic liner fracture was associated with impingement associated with excessive anteversion of the acetabular cup in Korean patients who habitually squat...
  43. pmc Improved results of primary total hip replacement
    Bjørg Tilde S Fevang
    Department of Rheumatology, Haukeland University Hospital, Norway
    Acta Orthop 81:649-59. 2010
    ..For this reason, we wanted to investigate the results after hip replacement in terms of revision rate, during a 21-year period among hip replacements reported to the Norwegian Arthroplasty Register...
  44. ncbi Medium term results of the collum femoris preserving hydroxyapatite coated total hip replacement
    I R Gill
    Department of Trauma and Orthopaedic Surgery, Mayday University Hospital, Croydon, UK
    Hip Int 18:75-80. 2008
    ..Survivorship was 97% and 100% at 3 years for the cup and stem respectively. Our findings suggest that the medium term results of the CFP stem are excellent...
  45. ncbi Migration pattern of a short femoral neck preserving stem
    S M Röhrl
    Department of Surgery and Perioperative Sciences, Umea University Hospital, Sweden
    Clin Orthop Relat Res 448:73-8. 2006
    ..The low migration of this short neck preserving stem suggests a favorable long-term outcome but longer followup is needed to substantiate this prediction. This design might become an alternative to standard stems and hip resurfacing...
  46. ncbi The effect of component size and orientation on the concentrations of metal ions after resurfacing arthroplasty of the hip
    D J Langton
    Joint Replacement Unit, University Hospital of North Tees, Hardwick, Stockton on Tees TS19 8PE, UK
    J Bone Joint Surg Br 90:1143-51. 2008
    ..Accurate positioning of the acetabular component intra-operatively is essential in order to reduce the concentration of metal ions in the blood after hip resurfacing arthroplasty with the Articular Surface Replacement implant...
  47. pmc A retrospective comparative study of mortality and causes of death among patients with metal-on-metal and metal-on-polyethylene total hip prostheses in primary osteoarthritis after a long-term follow-up
    Tuomo Visuri
    Research Institute of Military Medicine, Helsinki, Finland
    BMC Musculoskelet Disord 11:78. 2010
    ..We analyzed the causes of total and site-specific mortality among a cohort of patients with MM and with metal-on-polyethylene (MP) THA after a long follow-up time...
  48. ncbi Loosening and osteolysis associated with metal-on-metal bearings: A local effect of metal hypersensitivity?
    Joshua J Jacobs
    J Bone Joint Surg Am 88:1171-2. 2006
  49. ncbi Isolated fracture of the ceramic head after third-generation alumina-on-alumina total hip arthroplasty
    Kyung Hoi Koo
    Department of Orthopaedic Surgery, Seoul National University College of Medicine, 28 Yeongeon dong, Jongno gu, Seoul 110 744, South Korea
    J Bone Joint Surg Am 90:329-36. 2008
    ..In the present multicenter study, we investigated ceramic head fractures in a cohort of patients who underwent third-generation alumina-on-alumina total hip arthroplasty...
  50. pmc Histological features of pseudotumor-like tissues from metal-on-metal hips
    Pat Campbell
    J Vernon Luck Sr MD Orthopaedic Research Center, Orthopaedic Hospital UCLA, 2400 S Flower Street, Los Angeles, CA 90007, USA
    Clin Orthop Relat Res 468:2321-7. 2010
    ..The tissue features may help distinguish reactions to high wear from those with suspected metal hypersensitivity...
  51. pmc Outcome of prosthesis exchange for infected knee arthroplasty: the effect of treatment approach
    Esa Jämsen
    Medical School, University of Tampere, Tampere, Finland
    Acta Orthop 80:67-77. 2009
    ..The purpose of this literature review is to compare the clinical outcome achieved with one-stage revision and two-stage revision with different types of spacers...
  52. ncbi Comparison of the uncemented Cone and the cemented Bimetric hip prosthesis in young patients with osteoarthritis: an RSA, clinical and radiographic study
    Håkan Ström
    Department of Orthopedics, University of Uppsala, Sweden
    Acta Orthop 77:71-8. 2006
    ..There is no consensus as to whether uncemented or cemented femoral stems should be used in younger patients. We compared the uncemented Cone stem to the cemented Bimetric stem in young patients with osteoarthritis...
  53. ncbi Retrieval analysis of 240 metal-on-metal hip components, comparing modular total hip replacement with hip resurfacing
    A Matthies
    Department of Musculoskeletal Surgery, Imperial College London, London, United Kingdom
    J Bone Joint Surg Br 93:307-14. 2011
    ..These findings show that failed metal-on-metal hip resurfacing and modular THRs have similar component wear rates and are both associated with raised pre-revision blood levels of metal ions...
  54. ncbi Alumina-alumina artificial hip joints. Part II: characterisation of the wear debris from in vitro hip joint simulations
    J L Tipper
    Medical and Biological Engineering, School of Molecular Biology and Biochemistry, University of Leeds, UK
    Biomaterials 23:3441-8. 2002
    ....
  55. ncbi Early failures among 7,174 primary total knee replacements: a follow-up study from the Norwegian Arthroplasty Register 1994-2000
    Ove Furnes
    Department of Orthopaedic Surgery, Haukeland University Hospital, Bergen, Norway
    Acta Orthop Scand 73:117-29. 2002
    ..In tricompartmental knees, however, there were more revisions because of an infection. The relatively few patients with uncemented and hybrid implants showed no improvements in results compared to cemented knee prostheses...
  56. ncbi Revision rates after total joint replacement: cumulative results from worldwide joint register datasets
    G Labek
    European Arthroplasty Register, Scientific Office, Innsbruck, Austria
    J Bone Joint Surg Br 93:293-7. 2011
    ..29 revisions per 100 observed component years was seen. The outcomes of total hip and knee replacement are almost identical. Revision rates of about 6% after five years and 12% after ten years are to be expected...
  57. ncbi Adverse reaction to metal debris following hip resurfacing: the influence of component type, orientation and volumetric wear
    D J Langton
    Northern Deanery, Goldcrest Way, Newcastle upon Tyne, NE15 8NY, UK
    J Bone Joint Surg Br 93:164-71. 2011
    ..However, the extent of tissue destruction at revision surgery did not appear to be dose-related to the volumetric wear...
  58. ncbi Total knee arthroplasty in obese patients: a comparison with a matched control group
    Jared R H Foran
    Department of Orthopaedic Surgery, The Good Samaritan Hospital, Arthritis Division of The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Arthroplasty 19:817-24. 2004
    ..This may occur because of increasing stress at the bone-prosthesis interface, whereas increased activity levels in the nonobese patients may adversely affect the longevity of the polyethylene insert...
  59. pmc A prospective randomized study comparing electrochemically deposited hydroxyapatite and plasma-sprayed hydroxyapatite on titanium stems
    Berte Grimsmo Bøe
    Department of Orthopaedics, Oslo University Hospital, Ulleval, Norway
    Acta Orthop 82:13-9. 2011
    ..We investigated whether an electrochemically deposited hydroxyapatite, Bonemaster (BM), might be a safe alternative in total hip arthroplasty. Our hypothesis was that the new coating would not be inferior to the conventional one...
  60. ncbi Hip arthroplasty for salvage of failed treatment of intertrochanteric hip fractures
    George J Haidukewych
    Mayo Clinic, Rochester, Minnesota 55905, USA
    J Bone Joint Surg Am 85:899-904. 2003
    ..The purpose of the present study was to evaluate the results and complications of hip arthroplasty performed as a salvage procedure after the failed treatment of an intertrochanteric hip fracture...
  61. pmc Design-related risk factors for revision of primary cemented stems
    Truike M Thien
    Department of Orthopaedics, Institute of Clinical Sciences at Sahlgrenska Academy, University of Gothenburg, Sweden
    Acta Orthop 81:407-12. 2010
    ..We investigated whether design-related factors play any role in the risk of non-aseptic revision of the 3 most frequently used primary cemented stem designs in the Swedish Hip Arthroplasty Register...
  62. pmc AQUILA: assessment of quality in lower limb arthroplasty. An expert Delphi consensus for total knee and total hip arthroplasty
    Bart G Pijls
    Department of Orthopaedics, Leiden University Medical Center, Leiden, The Netherlands, Albinusdreef 2, Leiden, The Netherlands
    BMC Musculoskelet Disord 12:173. 2011
    ..A Delphi approach was used to develop a checklist for reporting quality, methodological quality and generalizability of case series and cohorts in total hip and total knee arthroplasty with a focus on aseptic loosening...
  63. ncbi Long-term results with cementless Fitek (or Fitmore) cups
    Piergiorgio Marchetti
    Clinica Ortopedica, Istituto Ortopedico Rizzoli, Bologna, Italy
    J Arthroplasty 20:730-7. 2005
    ..7 years, was 100% (end point: revision for any cause). Fitek cup showed good clinicoradiographic results...
  64. ncbi Early and late complications associated with transcatheter occlusion of secundum atrial septal defect
    Massimo Chessa
    Pediatric Cardiology, Istituto Policlinico San Donato, San Donato Milanese, Italy
    J Am Coll Cardiol 39:1061-5. 2002
    ..The goal of this study was to report the early and late complications experienced in atrial septal defect (ASD) transcatheter closure...
  65. pmc Alumina-on-alumina hip arthroplasty in patients younger than 30 years old
    R Nizard
    Department of Orthopaedic Surgery, Lariboisiere Hospital, 2, rue A Paré, 75010 Paris, France
    Clin Orthop Relat Res 466:317-23. 2008
    ..The main limiting factor in this series was the fixation of the acetabular component. However, improvements in the design and in the mode of fixation of this component should enhance long-term results...
  66. ncbi Primary total hip arthroplasty with a proximally porous-coated femoral stem
    Raj K Sinha
    University of Pittsburgh Medical Center, Pennsylvania, USA
    J Bone Joint Surg Am 86:1254-61. 2004
    ..The purpose of the present report was to examine the five to ten-year results associated with the use of a so-called second-generation circumferentially proximally porous-coated titanium-alloy stem...
  67. ncbi Immediate weight bearing after uncemented total hip arthroplasty with an anteverted stem: a prospective randomized comparison using radiostereometry
    Truike M Thien
    Department of Orthopaedics, Sahlgrenska University Hospital, Molndal, Sweden
    Acta Orthop 78:730-8. 2007
    ..In uncemented total hip arthroplasty with hydroxyapatite coating, early weight bearing is frequently practiced but there is still not much evidence to support this recommendation...
  68. ncbi Exposure to chromium, cobalt and molybdenum from metal-on-metal total hip replacement and hip resurfacing arthroplasty
    Wolf Christoph Witzleb
    Department of Orthopaedic Surgery, Universty Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany
    Acta Orthop 77:697-705. 2006
    ....
  69. ncbi FDG PET for differentiation of infection and aseptic loosening in total hip replacements: comparison with conventional radiography and three-phase bone scintigraphy
    Katrin D M Stumpe
    Department of Medical Radiology, Division of Nuclear Medicine, University Hospital, CH 8091 Zurich, Switzerland
    Radiology 231:333-41. 2004
    ....
  70. ncbi Blood and urine metal ion levels in young and active patients after Birmingham hip resurfacing arthroplasty: four-year results of a prospective longitudinal study
    J Daniel
    The McMinn Centre, 25 Highfield Road, Edgbaston, Birmingham B15 3DP, UK
    J Bone Joint Surg Br 89:169-73. 2007
    ..The levels in this study provide a baseline against which the in vivo wear performance of newer bearings can be compared...
  71. ncbi Hip resurfacings revised for inflammatory pseudotumour have a poor outcome
    G Grammatopolous
    Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Services University of Oxford, Headington, Oxford OX37LD, UK
    J Bone Joint Surg Br 91:1019-24. 2009
    ..The outcome of revision for pseudotumour is poor and consideration should be given to early revision to limit the extent of the soft-tissue destruction. The outcome of resurfacing revision for other causes is good...
  72. ncbi Orthopaedic metals and their potential toxicity in the arthroplasty patient: A review of current knowledge and future strategies
    G M Keegan
    University of Bristol, Bristol Implant Research Centre, Avon Orthopaedic Centre lower level, Southmead Hospital, Westbury on Trym, Bristol, BS10 5NB, UK
    J Bone Joint Surg Br 89:567-73. 2007
    ....
  73. pmc The association between metal allergy, total hip arthroplasty, and revision
    Jacob Pontoppidan Thyssen
    National Allergy Research Centre, Department of Dermato Allergology, Gentofte Hospital, University of Copenhagen, Copenhagen
    Acta Orthop 80:646-52. 2009
    ..Furthermore, we compared the prevalence of metal allergy in dermatitis patients with and without THA...
  74. pmc The Nordic Arthroplasty Register Association: a unique collaboration between 3 national hip arthroplasty registries with 280,201 THRs
    Leif I Havelin
    The Norwegian Arthroplasty Register, Department of Orthopaedic Surgery, Haukeland University Hospital, Bergen, Norway
    Acta Orthop 80:393-401. 2009
    ..In addition, we plan to study results in patient groups in which the numbers are too small to be studied in the individual countries...
  75. pmc Low rate of infected knee replacements in a nationwide series--is it an underestimate?
    Esa Jämsen
    Medical School, University of Tampere, Tampere, Finland
    Acta Orthop 80:205-12. 2009
    ..Specialist hospitals have reported an incidence of early deep infections of < 1% following primary knee replacement. The purpose of this study was to estimate the infection rate in a nationwide series using register-based data...
  76. pmc A prospective randomised study of "covered" versus "uncovered" diamond stents for the management of distal malignant biliary obstruction
    H Isayama
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Gut 53:729-34. 2004
    ..Covered self-expandable metal stents (EMS) were recently developed to overcome tumour ingrowth in conventional EMS. However, supporting evidence for the efficacy of covered EMS is lacking...
  77. ncbi Use of the reverse shoulder prosthesis for the treatment of failed hemiarthroplasty in patients with glenohumeral arthritis and rotator cuff deficiency
    J C Levy
    Orthopaedic Institute at Holy Cross, Fort Lauderdale, Florida 33308, USA
    J Bone Joint Surg Br 89:189-95. 2007
    ..However, high rates of complications were associated with glenoid and proximal humeral bone loss...
  78. ncbi A new model-based RSA method validated using CAD models and models from reversed engineering
    B L Kaptein
    Department of Orthopaedics, Leiden University Medical Center, P O Box 9600 RC, Leiden 2300, The Netherlands
    J Biomech 36:873-82. 2003
    ..05 degrees. Studies with clinical RSA-radiographs must prove that these results can also be reached in a clinical setting, making model-based RSA a possible alternative for marker-based RSA...
  79. ncbi Aseptic loosening, not only a question of wear: a review of different theories
    Mikael Sundfeldt
    Department of Biomaterials Handicap Research, Sahlgrenska University Hospital, University of Gothenburg, Sweden
    Acta Orthop 77:177-97. 2006
    ..In this review, we discuss the most common theories concerning aseptic loosening. It emerges from this review that aseptic loosening has a multifactorial etiology and cannot be explained by a single theory...
  80. ncbi Revision following cemented and uncemented primary total hip replacement: a seven-year analysis from the New Zealand Joint Registry
    G J Hooper
    Department of Orthopaedic Surgery and Musculoskeletal Medicine, Christchurch Public Hospital, Private Bag, PO Box 4710 Christchurch, New Zealand
    J Bone Joint Surg Br 91:451-8. 2009
    ....
  81. ncbi Cup inclination angle of greater than 50 degrees increases whole blood concentrations of cobalt and chromium ions after metal-on-metal hip resurfacing
    A J Hart
    Department of Musculoskeletal Surgery, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, UK
    Hip Int 18:212-9. 2008
    ..The implication is that metal levels can be minimised with optimal orientation of the acetabular component...
  82. ncbi The premature failure of the Charnley Elite-Plus stem: a confirmation of RSA predictions
    J Hauptfleisch
    Oxford Orthopaedic Engineering Centre The Botnar Research Centre, University of Oxford, Nuffield Orthopaedic Centre, Windmill Road, Headington, Oxford OX3 7LD, UK
    J Bone Joint Surg Br 88:179-83. 2006
    ..Our findings have also shown that rapid posterior head migration is predictive of premature loosening and a better predictor than subsidence...
  83. pmc Less wear with aluminium-oxide heads than cobalt-chrome heads with ultra high molecular weight cemented polyethylene cups: a ten-year follow-up with radiostereometry
    Jon Dahl
    Orthopaedic Department, Oslo University Hospital, N 0407, Oslo, Norway
    Int Orthop 36:485-90. 2012
    ..Both alumina (Al(2)O(3)) and cobalt-chrome (CoCr) femoral heads are commonly used. We investigated wear comparing alumina heads to cobalt-chrome heads against conventional cemented polyethylene (PE) cups for up to ten years...
  84. ncbi Comparison of the Norwegian knee arthroplasty register and a United States arthroplasty registry
    Elizabeth W Paxton
    Department of Surgical Outcomes and Analysis, Kaiser Permanente, 3033 Bunker Hill Street, San Diego, CA 92109, USA
    J Bone Joint Surg Am 93:20-30. 2011
    ..Patient characteristics, selection of implants, surgical techniques, and outcomes differed between the cohorts. Harmonization of data elements and definitions is necessary for future international research...
  85. pmc Endoprostheses last longer than intramedullary devices in proximal femur metastases
    Norah Harvey
    Department of Orthopedics, University of Southern California Los Angeles County Medical Center, Los Angeles, CA, USA
    Clin Orthop Relat Res 470:684-91. 2012
    ..Intramedullary devices are less expensive, less invasive, and may yield improved function over endoprostheses. However, it is unclear which, if either, has any advantages...
  86. pmc Mechanical properties, oxidation, and clinical performance of retrieved highly cross-linked Crossfire liners after intermediate-term implantation
    Steven M Kurtz
    Implant Research Center, School of Biomedical Engineering, Science, and Health, Systems, Drexel University, Philadelphia, PA 19104, USA
    J Arthroplasty 25:614-23.e1-2. 2010
    ..Rim surface damage, however, was observed in only 3 (5%) of 60 cases. Retrieval analysis of the 3 rim-damaged liners did not reveal an association between surface damage and the reasons for revision...
  87. ncbi Reverse total shoulder arthroplasty for failed shoulder arthroplasty
    Deepan N Patel
    Department of Orthopaedic Surgery, New York University Hospital of Joint Diseases, New York, NY 10003, USA
    J Shoulder Elbow Surg 21:1478-83. 2012
    ..Recently, the reverse total shoulder arthroplasty (rTSA) has been used in these difficult clinical situations. Therefore, we sought to examine our initial experience using rTSA as a treatment for failed shoulder arthroplasty...
  88. pmc Ceramic bearings for total hip arthroplasty have high survivorship at 10 years
    James A D'Antonio
    Greater Pittsburgh Orthopaedics Association, 725 Cherrington Parkway, Suite 200, Moon Township, PA 15108, USA
    Clin Orthop Relat Res 470:373-81. 2012
    ..In a previous study comparing ceramic with metal-on-polyethylene at 5 to 8 years, we found higher survivorship and no osteolysis for the ceramic bearings...
  89. ncbi Vascular tissue reaction to acute malapposition in human coronary arteries: sequential assessment with optical coherence tomography
    Juan Luis Gutiérrez-Chico
    Erasmus Medical Centre Thoraxcentre, Rotterdam, The Netherlands
    Circ Cardiovasc Interv 5:20-9, S1-8. 2012
    ..The vascular tissue reaction to acute incomplete stent apposition (ISA) is not well known. The aim of this study was to characterize the vascular response to acute ISA in vivo and to look for predictors of incomplete healing...
  90. pmc Aseptic failure: how does the Compress(®) implant compare to cemented stems?
    Andrew C Pedtke
    Department of Orthopaedic Surgery, University of California San Francisco, San Francisco, CA 94115 1939, USA
    Clin Orthop Relat Res 470:735-42. 2012
    ..Though the existing literature suggests survivorship of Compress(®) and stemmed implants is similar in the short term, studies are limited by population size and followup duration...
  91. pmc Indications and results of hip resurfacing
    D J W McMinn
    The McMinn Centre, 25 Highfield Road, Edgbaston, Birmingham B15 3DP, UK
    Int Orthop 35:231-7. 2011
    ..The clinical history of one device cannot be extrapolated to other devices...
  92. ncbi A critique of revision rate as an outcome measure: re-interpretation of knee joint registry data
    J W Goodfellow
    Botnar Research Centre, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK
    J Bone Joint Surg Br 92:1628-31. 2010
    ..Furthermore, revision is much less sensitive than the OKS to clinical failure in both types and therefore exaggerates the success of knee replacements, particularly of TKR...
  93. pmc A randomized study on migration of the Spectron EF and the Charnley flanged 40 cemented femoral components using radiostereometric analysis at 2 years
    Thomas Kadar
    Department of Orthopaedic Surgery, Haukeland University Hospital, Bergen, Norway
    Acta Orthop 82:538-44. 2011
    ....
  94. pmc In vivo oxidation contributes to delamination but not pitting in polyethylene components for total knee arthroplasty
    Francisco J Medel
    Implant Research Center, School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, Pennsylvania, USA
    J Arthroplasty 26:802-10. 2011
    ..Despite the lower oxidation displayed by conventional retrievals, this study provides strong evidence that delamination secondary to in vivo oxidation may occur during the second decade of implantation...
  95. pmc Effects of hydroxyapatite coating on survival of an uncemented femoral stem. A Swedish Hip Arthroplasty Register study on 4,772 hips
    Stergios Lazarinis
    Department of Orthopaedics, Institute of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Acta Orthop 82:399-404. 2011
    ..However, the evidence behind the use of HA coating on femoral stems is ambiguous. We investigated survival of an uncemented, tapered titanium femoral stem that was available either with or without HA coating (Bi-Metric)...
  96. pmc Obesity in total hip arthroplasty--does it really matter? A meta-analysis
    Daniel Haverkamp
    Department of Orthopaedic Surgery, Tergooi Ziekenhuizen, Hilversum, The Netherlands
    Acta Orthop 82:417-22. 2011
    ..We performed a meta-analysis with the primary research question of whether obesity has a negative effect on short- and long-term outcome of total hip arthroplasty...
  97. ncbi Noninflammatory pseudotumor simulating venous thrombosis after metal-on-metal hip resurfacing
    Werner Maurer-Ertl
    Department of Orthopedic Surgery, Medical University of Graz, Austria
    Orthopedics 34:e678-81. 2011
    ..At 30-month follow-up, the patient was doing well and there were no signs of local recurrence. Additionally, the metal ion levels of cobalt and chromium in the blood had significantly decreased...
  98. pmc History and systematic review of wear and osteolysis outcomes for first-generation highly crosslinked polyethylene
    Steven M Kurtz
    Exponent, Inc, 3401 Market Street, Suite 300, Philadelphia, PA 19104, USA
    Clin Orthop Relat Res 469:2262-77. 2011
    ....
  99. ncbi Increased expression of toll-like receptors in aseptic loose periprosthetic tissues and septic synovial membranes around total hip implants
    Yasunobu Tamaki
    Department of Orthopaedic Surgery, Yamagata University School of Medicine, Yamagata 990 9585, Japan
    J Rheumatol 36:598-608. 2009
    ..Our objective was to elucidate tissue localization and functional roles of TLR in periprosthetic tissues in 2 different pathologic conditions, aseptic and septic implant loosening...
  100. ncbi Avascular necrosis associated with fracture of the femoral neck after hip resurfacing: histological assessment of femoral bone from retrieval specimens
    R T Steffen
    Nuffield Orthopaedic Centre, University of Oxford, Oxford, UK
    J Bone Joint Surg Br 92:787-93. 2010
    ..This indicates established avascular necrosis and suggests that damage to the blood supply at the time of surgery is a potent risk factor for fracture of the femoral neck after hip resurfacing...
  101. pmc Dual mobility cup reduces dislocation rate after arthroplasty for femoral neck fracture
    Sarunas Tarasevicius
    Department of Orthopedics, Lund University Hospital, Getingevagen 4, Lund, Sweden
    BMC Musculoskelet Disord 11:175. 2010
    ..The aim of our study was to investigate the dislocation rate in acute femoral neck fracture patients operated with a posterior approach with cemented conventional or dual articulation acetabular components...

Research Grants27

  1. Superhard Nanocrystalline Coated Prosthesis
    Eric Tobin; Fiscal Year: 2004
    ..UHMWPE wear is a primary cause of prosthesis failure, and roughness of the mating Co-Cr surface has been identified as a major contributing factor to UHMWPE wear...
  2. GRADED FILMS ON CO-CR FOR REDUCED UHMWPE WEAR
    FEREYDOON NAMAVAR; Fiscal Year: 2000
    ..UHMWPE wear is a primary cause of prosthesis failure, and roughness of the mating Co-Cr surface has been identified as a major contributing factor to UHMWPE wear...
  3. The study of gene therapy for aseptic loosening using a mouse implant model
    Shang You Yang; Fiscal Year: 2009
    ..and pathological aspects of a longterm mouse model of debris-associated bone resorption and joint prosthesis failure;(2) to evaluate the efficacy of combination anti-inflammatory and anti-osteolytic gene therapy in preventing ..
  4. CONTROLLED-RELEASE SEALANT TO PREVENT SECONDARY CARIES
    Kenneth Anusavice; Fiscal Year: 2004
    ..mutans, site specific levels of S. mutans at the margins of amalgam and composite restorations, and the width of marginal crevices adjacent to amalgam and composite restorations). ..
  5. Daily Activity of TKR Patients as Input for Wear Testing
    Markus Wimmer; Fiscal Year: 2008
    ..Based on the kinematic and kinetic in vivo data derived in the motion laboratory, we will calculate contact forces using a mathematical model of the artificial knee. [unreadable] [unreadable] [unreadable]..
  6. Tissue Engineering of Cartilage using Periosteum
    SHAWN O DRISCOLL; Fiscal Year: 2008
    ..In addition, by eliminating the need for cell culture expansion facilities and expertise, the cost of this approach should be considerably less thereby making cartilage repair more globally accessible. ..
  7. Cleveland Clinic Orthopaedic Research Training Grant
    JOSEPH IANNOTTI; Fiscal Year: 2008
    ..abstract_text> ..
  8. Annular and Sub-Valvular Repair Techniques for Ischemic Mitral Regurgitation: In-
    Ajit P Yoganathan; Fiscal Year: 2010
    ..abstract_text> ..
  9. Osteolysis and Implant Wear: Biological, Biomedical Engineering, and Surgical Pri
    Stuart Goodman; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  10. Analyses of InSitu and Explanted Surgical Implant Devices
    Jack Lemons; Fiscal Year: 2009
    ..abstract_text> ..
  11. Antiproliferative Rx for venous neointimal hyperplasia
    Prabir Roy Chaudhury; Fiscal Year: 2005
    ..We believe that the results from this study could transform the clinical care of hemodialysis patients and at the same time result in the successful clinical application of local therapy for the treatment of neointimal hyperplasia...
  12. Effects of AGE/RAGE on Monocytes in Arteriogenesis
    William Nicholson; Fiscal Year: 2004
    ..abstract_text> ..
  13. MECHANICAL FACTORS IN CARTILAGE REPAIR
    SHAWN O DRISCOLL; Fiscal Year: 2004
    ..It is felt that these findings will have relevance to other important area of orthopedics, including fracture healing, and have significant potential to impact the care of patients. ..
  14. Dental Implant Science & Tech Transfer Satellite Meeting
    Jack Lemons; Fiscal Year: 2004
    ..Both organizations, IRG and WCOI-6 have approved the collaborations. Experience has been that 400 or more implant dentists attend the WCOI-6 and i00 or more researchers attend the IRG satellite sessions. ..
  15. Infusion of Particles at Implant interfeces
    Stuart Goodman; Fiscal Year: 2006
    ..abstract_text> ..
  16. Fluid Mechanics of the Mitral Valve: In Vitro Studies
    Ajit Yoganathan; Fiscal Year: 2004
    ..The use of state of the art measurement systems unavailable for in vivo use will yield significant results. ..
  17. Improving Flow Dynamics in Fontan Surgeries
    Ajit Yoganathan; Fiscal Year: 2006
    ....
  18. Bioreactivity Markers in Total Hip Replacments
    Nadim Hallab; Fiscal Year: 2004
    ..Additionally, variable immunologic responses induced by implant degradation products (i.e. lymphocyte response to metal ions and monocyte/macrophage response to particulate debris) will be correlated with the development of osteolysis ..
  19. Wear Analysis of Intervertebral Total Disc Replacements
    Thomas Brown; Fiscal Year: 2009
    ....
  20. Fatigue Crack Morphology in Cemented Hips
    Amos Race; Fiscal Year: 2002
    ....
  21. Dermatopharmacokinetics: In Vivo Analysis of Solvents
    Karla Thrall; Fiscal Year: 2005
    ..To evaluate the kinetics and dermal bioavailability of ethylbenzene, styrene, and toluene vapor using F344 rats. ..
  22. NONLINEAR COMPUTATIONAL BIOMECHANICS OF THE HIP
    Thomas Brown; Fiscal Year: 2004
    ..This partnership proposes to bring together a critical mass of engineers and surgeons, to achieve clinically grounded advances in nonlinear numerical simulations of surgery of the hip. ..
  23. Colon and liver anticarcinogenicity by acetaminophen
    Gary Williams; Fiscal Year: 2004
    ..In addition, these experiments will provide support for the epidemiological observations of reduced cancer risk associated with the use of APAP. ..
  24. Utilizing Saliva to Measure Bone Turnover
    Sreenivas Koka; Fiscal Year: 2007
    ..We anticipate that our results will identify how salivary biomarkers can be used to assess the osseo-status of patients with, or at risk for, osteoporosis. [unreadable] [unreadable] [unreadable] [unreadable]..
  25. Effect of Femoral Stem Design om Cement Mantle Failure
    Amos Race; Fiscal Year: 2006
    ..Should these aims be met, the proposed model will be of great use in pre-clinical testing of novel cemented stem designs. ..
  26. The Emu as a Model for Necrotic Femoral Head Collapse
    Thomas Brown; Fiscal Year: 2006
    ....