prosthesis design

Summary

Summary: The plan and delineation of prostheses in general or a specific prosthesis.

Top Publications

  1. ncbi The Norwegian Arthroplasty Register: 11 years and 73,000 arthroplasties
    L I Havelin
    Department of Orthopaedic Surgery, Haukeland University Hospital, Norway
    Acta Orthop Scand 71:337-53. 2000
  2. ncbi Six-year results of a prospective study of metal ion levels in young patients with metal-on-metal hip resurfacings
    J Daniel
    The McMinn Centre, 25 Highfield Road, Birmingham B15 3DP, UK
    J Bone Joint Surg Br 91:176-9. 2009
  3. ncbi Energy expenditure and biomechanical characteristics of lower limb amputee gait: the influence of prosthetic alignment and different prosthetic components
    Thomas Schmalz
    Department of Research, Otto Bock Health Care, Duderstadt, Germany
    Gait Posture 16:255-63. 2002
  4. ncbi A robust, real-time control scheme for multifunction myoelectric control
    Kevin Englehart
    Department of Biomedical Engineering, University of New Brunswick, 25 Dineen Drive, Fredericton, NB E3B5A3, Canada
    IEEE Trans Biomed Eng 50:848-54. 2003
  5. ncbi Unilateral versus bilateral endoscopic metal stenting for malignant hilar biliary obstruction
    Itaru Naitoh
    Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Gastroenterol Hepatol 24:552-7. 2009
  6. pmc Early migration characteristics of a hydroxyapatite-coated femoral stem: an RSA study
    David Campbell
    Orthopaedic Unit, Repatriation General Hospital, Adelaide, South Australia, Australia
    Int Orthop 35:483-8. 2011
  7. pmc How successful are current ankle replacements?: a systematic review of the literature
    Nikolaos Gougoulias
    Centre for Sports and Exercise Medicine, Barts and the London School of Medicine and Dentistry, Mile End Hospital, 275 Bancroft Road, London E1 4DG, UK
    Clin Orthop Relat Res 468:199-208. 2010
  8. pmc Risk of cancer with metal-on-metal hip replacements: population based study
    Keijo T Mäkelä
    Department of Orthopaedics and Traumatology, Surgical Hospital, Turku University Hospital, FI 20701 Turku, Finland
    BMJ 345:e4646. 2012
  9. ncbi Early failure of metal-on-metal bearings in hip resurfacing and large-diameter total hip replacement: A consequence of excess wear
    D J Langton
    North Tees and Hartlepool NHS Trust, Stockton on Tees and Centre for Rehabilitation, Newcastle University, Newcastle upon Tyne, England
    J Bone Joint Surg Br 92:38-46. 2010
  10. ncbi Transcatheter aortic valve implantation: first results from a multi-centre real-world registry
    Ralf Zahn
    Abteilung fur Kardiologie, Herzzentrum Ludwigshafen, Bremserstrasse 79, Ludwigshafen, Germany
    Eur Heart J 32:198-204. 2011

Detail Information

Publications332 found, 100 shown here

  1. ncbi The Norwegian Arthroplasty Register: 11 years and 73,000 arthroplasties
    L I Havelin
    Department of Orthopaedic Surgery, Haukeland University Hospital, Norway
    Acta Orthop Scand 71:337-53. 2000
    ..Since the practice of using undocumented implants has not changed, the register will continue to survey these implants. We plan to assess the mid- and long-term results of implants that have so far had good short-term results...
  2. ncbi Six-year results of a prospective study of metal ion levels in young patients with metal-on-metal hip resurfacings
    J Daniel
    The McMinn Centre, 25 Highfield Road, Birmingham B15 3DP, UK
    J Bone Joint Surg Br 91:176-9. 2009
    ..Subsequently there is a decreasing trend in excretion of both cobalt and chromium. The levels of cobalt and chromium in whole blood also show a significant increase at one year, followed by a decreasing trend until the sixth year...
  3. ncbi Energy expenditure and biomechanical characteristics of lower limb amputee gait: the influence of prosthetic alignment and different prosthetic components
    Thomas Schmalz
    Department of Research, Otto Bock Health Care, Duderstadt, Germany
    Gait Posture 16:255-63. 2002
    ..All investigated variations can be clearly characterized by the sagittal moments acting on the joints of the prosthetic limb during gait...
  4. ncbi A robust, real-time control scheme for multifunction myoelectric control
    Kevin Englehart
    Department of Biomedical Engineering, University of New Brunswick, 25 Dineen Drive, Fredericton, NB E3B5A3, Canada
    IEEE Trans Biomed Eng 50:848-54. 2003
    ..Finally, minimal storage capacity is required, which is an important factor in embedded control systems...
  5. ncbi Unilateral versus bilateral endoscopic metal stenting for malignant hilar biliary obstruction
    Itaru Naitoh
    Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Gastroenterol Hepatol 24:552-7. 2009
    ..The aim of this study was to compare endoscopic unilateral versus bilateral drainage in patients with malignant hilar biliary obstruction using a self-expanding metal stent (SEMS)...
  6. pmc Early migration characteristics of a hydroxyapatite-coated femoral stem: an RSA study
    David Campbell
    Orthopaedic Unit, Repatriation General Hospital, Adelaide, South Australia, Australia
    Int Orthop 35:483-8. 2011
    ..The results from this study can be compared with those from novel cementless stem designs to help predict the long-term outcome one may expect from new cementless stem designs...
  7. pmc How successful are current ankle replacements?: a systematic review of the literature
    Nikolaos Gougoulias
    Centre for Sports and Exercise Medicine, Barts and the London School of Medicine and Dentistry, Mile End Hospital, 275 Bancroft Road, London E1 4DG, UK
    Clin Orthop Relat Res 468:199-208. 2010
    ..The overall failure rate was approximately 10% at 5 years with a wide range (range, 0%-32%) between different centers. Superiority of an implant design over another cannot be supported by the available data...
  8. pmc Risk of cancer with metal-on-metal hip replacements: population based study
    Keijo T Mäkelä
    Department of Orthopaedics and Traumatology, Surgical Hospital, Turku University Hospital, FI 20701 Turku, Finland
    BMJ 345:e4646. 2012
    ..To assess the risk of cancer associated with modern primary metal-on-metal hip replacements...
  9. ncbi Early failure of metal-on-metal bearings in hip resurfacing and large-diameter total hip replacement: A consequence of excess wear
    D J Langton
    North Tees and Hartlepool NHS Trust, Stockton on Tees and Centre for Rehabilitation, Newcastle University, Newcastle upon Tyne, England
    J Bone Joint Surg Br 92:38-46. 2010
    ..Surgeons must consider implant design, expected component size and acetabular component positioning in order to reduce early failures when performing large-bearing metal-on-metal hip resurfacing and replacement...
  10. ncbi Transcatheter aortic valve implantation: first results from a multi-centre real-world registry
    Ralf Zahn
    Abteilung fur Kardiologie, Herzzentrum Ludwigshafen, Bremserstrasse 79, Ludwigshafen, Germany
    Eur Heart J 32:198-204. 2011
    ..We report the first results of the prospective multi-centre German Transcatheter Aortic Valve Interventions-Registry...
  11. pmc Risk of cancer in first seven years after metal-on-metal hip replacement compared with other bearings and general population: linkage study between the National Joint Registry of England and Wales and hospital episode statistics
    Alison J Smith
    Musculosketal Research Unit, School of Clinical Sciences, University of Bristol, Avon Orthopaedic Centre, Bristol BS10 5NB, UK
    BMJ 344:e2383. 2012
    ....
  12. pmc Targeted muscle reinnervation for real-time myoelectric control of multifunction artificial arms
    Todd A Kuiken
    Neural Engineering Center for Artificial Limbs, Rehabilitation Institute of Chicago, 345 E Superior St, Room 1309, Chicago, IL 60611, USA
    JAMA 301:619-28. 2009
    ..After reinnervation, these target muscles produce electromyogram (EMG) signals on the surface of the skin that can be measured and used to control prosthetic arms...
  13. ncbi Vascular responses to drug eluting stents: importance of delayed healing
    Aloke V Finn
    CVPath Institute, Inc, 19 Firstfield, Road, Gaithersburg, MD 20878, USA
    Arterioscler Thromb Vasc Biol 27:1500-10. 2007
    ..Because the time course of complete healing with DES in man is unknown, the optimal duration of antiplatelet treatment remains to be determined...
  14. ncbi Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: a randomised non-inferiority trial
    David R Holmes
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Lancet 374:534-42. 2009
    ..We assessed the efficacy and safety of percutaneous closure of the LAA for prevention of stroke compared with warfarin treatment in patients with atrial fibrillation...
  15. ncbi Diagnostic evaluation of left-sided prosthetic heart valve dysfunction
    Jesse Habets
    Department of Radiology, University Medical Center, Utrecht, P O Box 85500, 3508 GA, The Netherlands j habets umcutrecht nl
    Nat Rev Cardiol 8:466-78. 2011
    ..In this Review, we discuss the use of established imaging modalities for the detection of left-sided mechanical and biological PHV dysfunction and discuss the complementary role of MDCT in this context...
  16. ncbi Metal-on-metal bearings: the evidence so far
    F S Haddad
    Department of Orthopaedics, University College Hospital, 235 Euston Road, London NW1 2BU, UK
    J Bone Joint Surg Br 93:572-9. 2011
    ..This review examines the literature and contemporary presentations on current clinical dilemmas in metal-on-metal hip replacement...
  17. ncbi Five-year results of the ASR XL Acetabular System and the ASR Hip Resurfacing System: an analysis from the Australian Orthopaedic Association National Joint Replacement Registry
    Richard N de Steiger
    Australian Orthopaedic Association National Joint Replacement Registry, Discipline of Public Health, University of Adelaide, Adelaide, SA, Australia
    J Bone Joint Surg Am 93:2287-93. 2011
    ..This report summarizes an analysis by the Australian Orthopaedic Association National Joint Replacement Registry (AOANJRR) of the outcome of arthroplasties involving the ASR prostheses...
  18. ncbi Accelerating failure rate of the ASR total hip replacement
    D J Langton
    Northern Deanery, Goldcrest Way, Newcastle upon Tyne NE15 8NY, UK
    J Bone Joint Surg Br 93:1011-6. 2011
    ..Our results suggest that wear at the modular junction is an important factor in the development of adverse tissue reactions after implantation of a large-diameter MoM THR...
  19. ncbi Percutaneous repair or surgery for mitral regurgitation
    Ted Feldman
    Evanston Hospital, NorthShore University Health System, Evanston, IL 60201, USA
    N Engl J Med 364:1395-406. 2011
    ..Mitral-valve repair can be accomplished with an investigational procedure that involves the percutaneous implantation of a clip that grasps and approximates the edges of the mitral leaflets at the origin of the regurgitant jet...
  20. ncbi Wear mechanisms in metal-on-metal bearings: the importance of tribochemical reaction layers
    Markus A Wimmer
    Department of Orthopedic Surgery, Rush University Medical Center, 1653 West Congress Parkway, Chicago, Illinois 60612, USA
    J Orthop Res 28:436-43. 2010
    ..This novel finding of a mechanically mixed zone of nanocrystalline metal and organic constituents provides the basis for understanding particle release and may help in identifying new strategies to reduce MoM wear...
  21. pmc Inferior outcome after hip resurfacing arthroplasty than after conventional arthroplasty. Evidence from the Nordic Arthroplasty Register Association (NARA) database, 1995 to 2007
    Per Erik Johanson
    Department of Orthopedics, Sahlgrenska University Hospital, University of Gothenburg, Sweden
    Acta Orthop 81:535-41. 2010
    ..We therefore determined the outcome of HRA in the NARA database, which is common to all 3 countries, and compared it to the outcome of conventional total hip arthroplasty (THA)...
  22. pmc Competing risks survival analysis applied to data from the Australian Orthopaedic Association National Joint Replacement Registry
    Marianne H Gillam
    School of Population Health and Clinical Practice, University of Adelaide, Adelaide, Australia
    Acta Orthop 81:548-55. 2010
    ..In the presence of a competing risk such as death, KM is known to overestimate the probability of revision. We investigated the degree to which the risk of revision is overestimated in registry data...
  23. ncbi Evaluation of the Medtronic (Driver) cobalt-chromium alloy coronary stent system
    Michael H Sketch
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Cardiol 95:8-12. 2005
    ..4% at 180 days. In-stent late loss was 0.94 mm at 180 days, and no subacute stent thromboses were observed. This registry demonstrated the safety and efficacy of this novel coronary stent platform...
  24. ncbi Assessment of the absorption process following bioabsorbable everolimus-eluting stent implantation: temporal changes in strain values and tissue composition using intravascular ultrasound radiofrequency data analysis. A substudy of the ABSORB clinical tri
    Hector M Garcia-Garcia
    Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands
    EuroIntervention 4:443-8. 2009
    ....
  25. ncbi Femoral head size is a risk factor for total hip luxation: a study of 42,987 primary hip arthroplasties from the Norwegian Arthroplasty Register
    Sven Byström
    Department of Orthopaedic Surgery, Haukeland University Hospital, Bergen, Norway
    Acta Orthop Scand 74:514-24. 2003
    ..A posterior approach increased the risk of revision more than a lateral one (FRR 1.9, 95% CI 1.4-2.5). Gender, trochanteric osteotomy and duration of the operation did not affect the results...
  26. pmc Design of a cybernetic hand for perception and action
    M C Carrozza
    ARTS Lab, Scuola Superiore Sant Anna, Pontedera Pi, Italy
    Biol Cybern 95:629-44. 2006
    ....
  27. pmc Minimizing dynamic knee spacer complications in infected revision arthroplasty
    Aaron J Johnson
    Center for Joint Preservation and Replacement, Rubin Institute for Advanced Orthopedics, Sinai Hospital of Baltimore, 2401 West Belvedere Avenue, Baltimore, MD 21215, USA
    Clin Orthop Relat Res 470:220-7. 2012
    ..However, because of several dynamic spacer problems noted at our institution, we wanted to assess their associated failures, reinfection rates, and functionality...
  28. ncbi Failure rates of metal-on-metal hip resurfacings: analysis of data from the National Joint Registry for England and Wales
    Alison J Smith
    Orthopaedic Surgery, Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol, Bristol, UK
    Lancet 380:1759-66. 2012
    ..We assessed the survival of different sizes of metal-on-metal resurfacing in men and women, and compared this survival with those for conventional stemmed THRs...
  29. ncbi Pseudotumors in association with well-functioning metal-on-metal hip prostheses: a case-control study using three-dimensional computed tomography and magnetic resonance imaging
    Alister J Hart
    Department of Orthopaedic Surgery, Charing Cross Hospital Imperial College Healthcare NHS Trust and Imperial College London, Fulham Palace Road, London W6 8RF, United Kingdom
    J Bone Joint Surg Am 94:317-25. 2012
    ....
  30. pmc Quantifying pattern recognition-based myoelectric control of multifunctional transradial prostheses
    Guanglin Li
    Neural Engineering Center for Artificial Limbs, Rehabilitation Institute of Chicago, Chicago, IL 60611, USA
    IEEE Trans Neural Syst Rehabil Eng 18:185-92. 2010
    ....
  31. pmc Hip resurfacing arthroplasty: short-term survivorship of 4,401 hips from the Finnish Arthroplasty Register
    Matti Seppänen
    Department of Orthopaedics and Traumatology, Turku University Hospital, Turku, Finland
    Acta Orthop 83:207-13. 2012
    ..We analyzed the short-term survival of 4,401 HRAs in the Finnish Arthroplasty Register...
  32. ncbi One-year prospective comparative study of three large-diameter metal-on-metal total hip prostheses: serum metal ion levels and clinical outcomes
    J F Lardanchet
    Department of Orthopaedic Surgery, North Amiens Teaching Hospital Center, 1, Place Victor Pauchet, 80000 Amiens, France
    Orthop Traumatol Surg Res 98:265-74. 2012
    ....
  33. pmc Hip arthroplasty in patients younger than 30 years: excellent ten to 16-year follow-up results with a HA-coated stem
    H Wangen
    Department of Orthopaedics, Rikshospitalet Radiumhospitalet Medical Centre, 0027, Oslo, Norway
    Int Orthop 32:203-8. 2008
    ..In conclusion, we found mechanical failures at the acetabular side, but excellent results with a fully HA-coated femoral stem, with no revisions after ten to 16 years...
  34. ncbi A trabecular metal tibial component in total knee replacement in patients younger than 60 years: a two-year radiostereophotogrammetric analysis
    A Henricson
    Umea University Hospital, Umea, Sweden
    J Bone Joint Surg Br 90:1585-93. 2008
    ..This pattern of subsidence is regarded as being beneficial for uncemented fixation...
  35. ncbi Multimodal assessment of the aortic annulus diameter: implications for transcatheter aortic valve implantation
    David Messika-Zeitoun
    INSERM, U698, University Paris 7, Paris, France
    J Am Coll Cardiol 55:186-94. 2010
    ....
  36. ncbi Correctness of multi-detector-row computed tomography for diagnosing mechanical prosthetic heart valve disorders using operative findings as a gold standard
    I Chen Tsai
    Department of Radiology, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China
    Eur Radiol 19:857-67. 2009
    ..Except for images impaired by severe beam-hardening artifacts, MDCT provides excellent delineation of prosthetic valve disorders...
  37. ncbi The effect of hydroxyapatite on the micromotion of total knee prostheses. A prospective, randomized, double-blind study
    R G Nelissen
    Department of Orthopaedic Surgery, Leiden University Medical Centre, The Netherlands
    J Bone Joint Surg Am 80:1665-72. 1998
    ..Therefore, hydroxyapatite, a biological mediator, may be necessary for the adequate fixation of tibial components when cement is not used...
  38. pmc Decoding of grasping information from neural signals recorded using peripheral intrafascicular interfaces
    Silvestro Micera
    BioRobotics Institute, Scuola Superiore Sant Anna, Pisa, Italy
    J Neuroeng Rehabil 8:53. 2011
    ..This goal can be achieved with several approaches and among them, the use of implantable interfaces connected with the peripheral nervous system, namely intrafascicular electrodes, is considered particularly interesting...
  39. ncbi Sensitivity and specificity of blood cobalt and chromium metal ions for predicting failure of metal-on-metal hip replacement
    A J Hart
    Imperial College London, Department of Musculoskeletal Surgery, Charing Cross Hospital Campus, Fulham Palace Road, London W6 8RF, UK
    J Bone Joint Surg Br 93:1308-13. 2011
    ..Blood metal ions had good discriminant ability to separate failed from well-functioning hip replacements. The MHRA cut-off level of 7 ppb provides a specific test but has poor sensitivity...
  40. pmc Risk factors for revision due to infection after primary total hip arthroplasty. A population-based study of 80,756 primary procedures in the Danish Hip Arthroplasty Registry
    Alma B Pedersen
    Department of Clinical Epidemiology, Aarhus University Hospital, Arhus, Denmark
    Acta Orthop 81:542-7. 2010
    ..We therefore studied patient- and surgery-related risk factors for revision due to infection after primary THA in a population-based setting...
  41. ncbi Mobile-bearing knee replacement: concepts and results
    J J Callaghan
    Department of Orthopaedics, University of Iowa, Iowa City, Iowa, USA
    Instr Course Lect 50:431-49. 2001
    ....
  42. ncbi Patient-prosthesis mismatch does not affect survival following aortic valve replacement
    Neil J Howell
    Department of Cardiothoracic Surgery, University Hospital NHS Foundation Trust, Birmingham, UK
    Eur J Cardiothorac Surg 30:10-4. 2006
    ..We analysed the effect of PPM at values predicting severe mismatch on survival following AVR in our unit...
  43. pmc The John Charnley Award: Metal-on-metal hip resurfacing versus large-diameter head metal-on-metal total hip arthroplasty: a randomized clinical trial
    Donald S Garbuz
    Division of Lower Limb Reconstruction and Oncology, Department of Orthopaedics, University of British Columbia, Room 3114, 910 West 10th Avenue, Vancouver, BC, V5Z 4E3, Canada
    Clin Orthop Relat Res 468:318-25. 2010
    ..6-fold higher than in the resurfacing arm. Due to these excessively high metal ion levels, the authors recommend against further use of this particular large-head total hip arthroplasty...
  44. ncbi Characterization of the running-in period in total hip resurfacing arthroplasty: an in vivo and in vitro metal ion analysis
    Christian Heisel
    Laboratory of Biomechanics and Implant Research, Department of Orthopaedics, University of Heidelberg, Schlierbacher Landstrasse 200a, 69117 Heidelberg, Germany
    J Bone Joint Surg Am 90:125-33. 2008
    ..The goal of this study was to characterize the early running-in period in vivo and in vitro by characterizing metal ion levels...
  45. ncbi Trans-apical aortic valve implantation using a new self-expandable bioprosthesis: initial outcomes
    Jörg Kempfert
    Heartcenter University of Leipzig, Leipzig, Germany
    Eur J Cardiothorac Surg 40:1114-9. 2011
    ..As an alternative device, a self-expanding sub-coronary trans-apical bioprosthesis was evaluated...
  46. ncbi Migration pattern of a short femoral neck preserving stem
    S M Röhrl
    Department of Surgery and Perioperative Sciences, Umea University Hospital, Sweden
    Clin Orthop Relat Res 448:73-8. 2006
    ..The low migration of this short neck preserving stem suggests a favorable long-term outcome but longer followup is needed to substantiate this prediction. This design might become an alternative to standard stems and hip resurfacing...
  47. pmc Late complications and survival of endoprosthetic reconstruction after resection of bone tumors
    Ahmad Shehadeh
    Washington Cancer Institute at Washington Hospital Center, Washington, DC, USA
    Clin Orthop Relat Res 468:2885-95. 2010
    ..While complications following massive endoprosthetic reconstruction have been previously described, the incidence and effects of these complications over extended periods of time have not been well characterized in large series...
  48. ncbi Prevalence of pseudotumor in asymptomatic patients after metal-on-metal hip arthroplasty
    Daniel H Williams
    Division of Lower Limb Reconstruction and Oncology, Department of Orthopaedics, University of British Columbia, 910 West 10th Avenue, Vancouver, BC, Canada
    J Bone Joint Surg Am 93:2164-71. 2011
    ..A secondary purpose was to assess whether a correlation exists between elevated serum metal ion levels and pseudotumor formation...
  49. ncbi The seven-year wear of highly cross-linked polyethylene in total hip arthroplasty: a double-blind, randomized controlled trial using radiostereometric analysis
    Geraint E R Thomas
    Biomedical Research Unit, Headington, Oxford OX3 7LD, United Kingdom
    J Bone Joint Surg Am 93:716-22. 2011
    ....
  50. ncbi The effect of component size and orientation on the concentrations of metal ions after resurfacing arthroplasty of the hip
    D J Langton
    Joint Replacement Unit, University Hospital of North Tees, Hardwick, Stockton on Tees TS19 8PE, UK
    J Bone Joint Surg Br 90:1143-51. 2008
    ..Accurate positioning of the acetabular component intra-operatively is essential in order to reduce the concentration of metal ions in the blood after hip resurfacing arthroplasty with the Articular Surface Replacement implant...
  51. ncbi Functional outcome after shoulder arthroplasty for primary osteoarthritis: a multicenter study
    Tom R Norris
    California Pacific Medical Center, San Francisco, California, USA
    J Shoulder Elbow Surg 11:130-5. 2002
    ..Postoperative humeral head subluxation is often associated with other factors including rotator cuff tears or glenoid component loosening...
  52. ncbi What is the benefit of introducing new hip and knee prostheses?
    Rajan Anand
    Discipline of Public Health, University of Adelaide, MDP DX650, 511 Australia SA 5005
    J Bone Joint Surg Am 93:51-4. 2011
    ..The underlying purpose of the introduction of new devices is to improve patient outcomes. This study was undertaken to determine how many new prostheses were associated with improved patient outcomes...
  53. ncbi Development and evaluation of an improved cochlear implant electrode design for electric acoustic stimulation
    Oliver Adunka
    ENT Department, J W Goethe University Frankfurt am Main, Frankfurt am Main, Germany
    Laryngoscope 114:1237-41. 2004
    ..Special emphasis was placed on the practicality for combined electric and acoustic stimulation of the auditory system...
  54. pmc Elevation of circulating HLA DR(+) CD8(+) T-cells and correlation with chromium and cobalt concentrations 6 years after metal-on-metal hip arthroplasty
    Nils P Hailer
    Department of Orthopedics, Institute of Surgical Sciences, Uppsala University Hospital, Sweden
    Acta Orthop 82:6-12. 2011
    ..We hypothesized that changes in lymphocyte subpopulations would be associated with elevated metal ion concentrations...
  55. ncbi An intraoperatively moulded PMMA prostheses like spacer for two-stage revision of infected total knee arthroplasty
    Sandro Kohl
    Department of Orthopaedic Surgery, Inselspital, University of Bern, Switzerland
    Knee 18:464-9. 2011
    ..The use of this spacer is a time sparing, cheap and convenient option in 2-stage TKA revision...
  56. ncbi Whole blood metal ion concentrations in correlation with activity level in three different metal-on-metal bearings
    Christophe A Pattyn
    Department of Orthopedic Surgery and Traumatology, Ghent University Hospital, Ghent, Belgium
    J Arthroplasty 26:58-64. 2011
    ..In conclusion, although the current second-generation metal bearings may show differences in ion release, more attention should be paid to the correlation between ion release and implant positioning...
  57. ncbi Biomechanical properties of orthodontic miniscrews. An in-vitro study
    Britta Florvaag
    Department of Orthodontics, University of Cologne, Cologne, Germany
    J Orofac Orthop 71:53-67. 2010
    ..Comparing five commercially-available miniscrew types for skeletal anchorage with regard to the biomechanical properties influencing their primary stability...
  58. ncbi Effect of swing phase load on metal-on-metal hip lubrication, friction and wear
    Sophie Williams
    School of Mechanical Engineering, Institute of Medical and Biological Engineering, University of Leeds, Leeds, LS2 9JT, UK
    J Biomech 39:2274-81. 2006
    ..This may explain some of the variations that have been observed with clinical wear rates...
  59. ncbi Prediction of range of motion 2 years after mobile-bearing total knee arthroplasty: PCL-retaining versus PCL-sacrificing
    Yoshinori Ishii
    Ishii Orthopaedic and Rehabilitation Clinic, 1089 Shimo Oshi, Gyoda, Saitama, 361 0037, Japan
    Knee Surg Sports Traumatol Arthrosc 19:2002-8. 2011
    ..This study evaluated the changes in the range of motion (ROM) with time postoperatively...
  60. ncbi A wavelet-based continuous classification scheme for multifunction myoelectric control
    K Englehart
    Department of Electrical and Computer Engineering and the Institute of Biomedical Engineering, University of New Brunswick, Fredericton, Canada
    IEEE Trans Biomed Eng 48:302-11. 2001
    ..Although in its preliminary stages of development, this scheme promises a more natural and efficient means of myoelectric control than one based on discrete, transient bursts of activity...
  61. ncbi Cemented versus uncemented fixation of the femoral component of the NexGen CR total knee replacement in patients younger than 60 years: a prospective randomised controlled RSA study
    Feng Gao
    Department of Orthopaedics, Umea University Hospital, Umea, Sweden
    Knee 16:200-6. 2009
    ..These findings suggest that an uncemented and non HA-coated femoral component may behave equally as well as a cemented one in the long-term...
  62. ncbi Changes over time in electrical stimulation levels and electrode impedance values in children using the Nucleus 24M cochlear implant
    Yael Henkin
    Department of Communication Disorders, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Int J Pediatr Otorhinolaryngol 67:873-80. 2003
    ..e. threshold levels, comfortable levels, dynamic range, and electrode impedance values during the 1st year post-implantation, in children using the Nucleus 24M cochlear implant system...
  63. ncbi Procedural, 30-day and one year outcome following CoreValve or Edwards transcatheter aortic valve implantation: results of the Belgian national registry
    Johan M Bosmans
    Department of Cardiology and Cardiac Surgery, Antwerp University Hospital, Antwerp, Belgium
    Interact Cardiovasc Thorac Surg 12:762-7. 2011
    ..This mid-term mortality was mainly related to age-related, non-cardiac complications...
  64. ncbi Differences in the fretting corrosion of metal-metal and ceramic-metal modular junctions of total hip replacements
    Nadim James Hallab
    Department of Orthopedic Surgery, Rush Presbyterian St Lukes Medical Center, 1653 W Congress Parkway, Chicago, IL 60612, USA
    J Orthop Res 22:250-9. 2004
    ....
  65. ncbi Quality of life evaluation after implantation of 2 multifocal intraocular lens models and a monofocal model
    Jorge L Alio
    Vissum Corporation Instituto Oftalmologico de Alicante, Avenida de Denia s n, Edificio Vissum, 03016 Alicante, Spain
    J Cataract Refract Surg 37:638-48. 2011
    ..To compare vision-related quality of life using the National Eye Institute Visual Function Questionnaire (NEI VFQ-25) in patients with 1 of 3 types of intraocular lenses (IOLs) and to correlate it with postoperative visual outcomes...
  66. ncbi Circulating levels of cobalt and chromium from metal-on-metal hip replacement are associated with CD8+ T-cell lymphopenia
    A J Hart
    Department of Musculoskeletal Surgery Charing Cross, Imperial College, London, England
    J Bone Joint Surg Br 91:835-42. 2009
    ....
  67. ncbi Long-term results of the ABG-1 hydroxyapatite coated total hip arthroplasty: analysis of 111 cases with a minimum follow-up of 10 years
    R Bidar
    Department of Orthopaedics and Traumatology, Carémeau Teaching Hospital Center, place du Pr Robert Debré, 30029 Nimes Cedex 9, France
    Orthop Traumatol Surg Res 95:579-87. 2009
    ....
  68. pmc Trabecular Metal cups for acetabular defects with 50% or less host bone contact
    Dror Lakstein
    Orthopedic Department, Division of Arthroplasty, Mount Sinai Hospital, 600 University Avenue, Suite 476A, Toronto, ON, M5G 1X5, Canada
    Clin Orthop Relat Res 467:2318-24. 2009
    ..The data suggest treatment of cavitary defects with less than 50% host bone contact using Trabecular Metal cups, without structural support by augments or structural bone grafts, is a reasonable option...
  69. ncbi Percutaneous transarterial aortic valve implantation: what do we know?
    John Webb
    St Paul s Hospital, University of British Columbia, 1081 Burrard Street, Vancouver, BC, Canada
    Eur Heart J 32:140-7. 2011
    ..Nevertheless considerable work needs to be done before the indications for TAVI are expanded into lower risk groups. We review what is currently known about percutaneous transarterial implantation of the aortic valve...
  70. ncbi Randomised controlled trial comparing early migration of two collarless polished cemented stems using radiostereometric analysis
    R W McCalden
    London Health Sciences Centre, University of Western Ontario, 339 Windermere Road, London, Ontario, Canada N6A 5A5
    J Bone Joint Surg Br 92:935-40. 2010
    ..The subtle differences in designs may explain the different patterns of migration. Comparable migration with the Exeter stem suggests that the CPCS design will perform well in the long term...
  71. ncbi Exposure to chromium, cobalt and molybdenum from metal-on-metal total hip replacement and hip resurfacing arthroplasty
    Wolf Christoph Witzleb
    Department of Orthopaedic Surgery, Universty Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany
    Acta Orthop 77:697-705. 2006
    ....
  72. ncbi Correlation between inclination of the acetabular component and metal ion levels in metal-on-metal hip resurfacing replacement
    R de Haan
    University Hospital Brussels, Laarbeeklaan 101, 1090 Brussels, Belgium
    J Bone Joint Surg Br 90:1291-7. 2008
    ..This is probably due to a greater risk of edge-loading...
  73. ncbi Immediate weight bearing after uncemented total hip arthroplasty with an anteverted stem: a prospective randomized comparison using radiostereometry
    Truike M Thien
    Department of Orthopaedics, Sahlgrenska University Hospital, Molndal, Sweden
    Acta Orthop 78:730-8. 2007
    ..In uncemented total hip arthroplasty with hydroxyapatite coating, early weight bearing is frequently practiced but there is still not much evidence to support this recommendation...
  74. ncbi Aortic annulus evaluation in transcatheter aortic valve implantation
    Andrea Hutter
    Clinic for Cardiovascular Surgery, German Heart Centre Munich, Munich, Germany
    Catheter Cardiovasc Interv 76:1009-19. 2010
    ..We compared the annulus diameters measured by transthoracic echocardiography (TTE), transesophageal echocardiography (TEE), and dual-source computed tomography (DSCT) before transcatheter aortic valve implantation (TAVI)...
  75. ncbi A prospective metal ion study of large-head metal-on-metal bearing: a matched-pair analysis of hip resurfacing versus total hip replacement
    Paul E Beaule
    The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada
    Orthop Clin North Am 42:251-7, ix. 2011
    ..51 vs 1.02, P = .002), and 2 years (3.77 vs 1.22, P<.001) following surgery. No differences in chromium ions were observed. Further research is required to determine the clinical significance of elevated serum cobalt ions...
  76. pmc Thirty years of experience with alumina-on-alumina bearings in total hip arthroplasty
    Didier Hannouche
    Department of Orthopaedic Surgery and Traumatology, AP HP, Hôpital Lariboisière University Paris 7, 2 rue Ambroise Pare, 75010 Paris, France
    Int Orthop 35:207-13. 2011
    ..4% at ten years. However, concern remains over ceramic liner fracture and squeaking, which has been noted recently with increasing prevalence. This review will discuss the current knowledge on the use of alumina-on-alumina bearings...
  77. pmc Cementless total hip arthroplasty with ceramic-on-ceramic bearing in patients younger than 45 years with femoral-head osteonecrosis
    Young Hoo Kim
    Joint Replacement Center of Korea, Ewha Womans University School of Medicine, Seoul, Korea
    Int Orthop 34:1123-7. 2010
    ..1-year follow-up in this series of young patients with femoral-head osteonecrosis...
  78. ncbi Serum cobalt and chromium elevations following hip resurfacing with the Cormet 2000 device
    D Gordon Allan
    Southern Illinois University, School of Medicine, Division of Orthopedics and Rehabilitation, Springfield, IL 62794 9679, USA
    J Surg Orthop Adv 16:12-8. 2007
    ..Future studies are needed to determine what serum Co/Cr levels are of clinical concern, particularly in outlier cases...
  79. ncbi Online myoelectric control of a dexterous hand prosthesis by transradial amputees
    Christian Cipriani
    The BioRobotics Institute formerly ARTS and CRIM Labs, Scuola Superiore Sant Anna, 56025 Pontedera, Italy
    IEEE Trans Neural Syst Rehabil Eng 19:260-70. 2011
    ..These results are encouraging for the development of noninvasive EMG interfaces for the control of dexterous prostheses...
  80. ncbi Initial evidence for the return of coronary vasoreactivity following the absorption of bioabsorbable magnesium alloy coronary stents
    Gopal Ghimire
    Royal Brompton and Harefield NHS Trust, Imperial College, London, United Kingdom
    EuroIntervention 4:481-4. 2009
    ....
  81. pmc Do ion levels in hip resurfacing differ from metal-on-metal THA at midterm?
    A Moroni
    Department II of Orthopaedics and Traumatology, Bologna University, Rizzoli Orthopaedic Institute, Via G C Pupilli 1, 40136 Bologna, Italy
    Clin Orthop Relat Res 469:180-7. 2011
    ..Metal-on-metal Birmingham hip resurfacing (MOM-BHR) is an alternative to metal-on-metal total hip arthroplasty (MOM-THA), especially for young and/or active patients. However, wear resulting in increased serum ion levels is a concern...
  82. ncbi Primary total hip arthroplasty with a proximally porous-coated femoral stem
    Raj K Sinha
    University of Pittsburgh Medical Center, Pennsylvania, USA
    J Bone Joint Surg Am 86:1254-61. 2004
    ..The purpose of the present report was to examine the five to ten-year results associated with the use of a so-called second-generation circumferentially proximally porous-coated titanium-alloy stem...
  83. ncbi Multidetector-row computed tomography imaging characteristics of mechanical prosthetic valves
    Petr Symersky
    Department of Cardiothoracic Surgery, Isala Klinieken Zwolle, The Netherlands
    J Heart Valve Dis 20:216-22. 2011
    ..A pulsatile in vitro model was developed to study the MDCT imaging characteristics of mechanical heart valves (MHVs)...
  84. pmc Follow-up of 11-16 years after modular fixed-bearing TKA
    D Parsch
    Department of Orthopaedic Surgery, University of Heidelberg, Heidelberg, Germany
    Int Orthop 33:431-5. 2009
    ..The mean Knee Society and function scores were 76 and 48 points, respectively. In this multi-surgeon series modular fixed-bearing TKA had good clinical and radiographic results with excellent long-term survivorship...
  85. ncbi Clinical and angiographic results with the next-generation resolute stent system: a prospective, multicenter, first-in-human trial
    Ian T Meredith
    Monash Heart Monash Medical Centre and University, Melbourne, Australia
    JACC Cardiovasc Interv 2:977-85. 2009
    ..The RESOLUTE trial examined the safety and efficacy of a next-generation zotarolimus-eluting coronary stent, Resolute (Medtronic CardioVascular Inc., Santa Rosa, California)...
  86. ncbi Long-term clinical outcomes with the next-generation Resolute Stent System: a report of the two-year follow-up from the RESOLUTE clinical trial
    Ian T Meredith
    MonashHEART Medical Centre, Melbourne, Australia
    EuroIntervention 5:692-7. 2010
    ..The 12-month results of RESOLUTE were favourable for the new Resolute stent. Two-year safety and efficacy results from RESOLUTE have been evaluated and are now reported...
  87. ncbi Multicenter study of the Artisan phakic intraocular lens
    C Budo
    J Cataract Refract Surg 26:1163-71. 2000
    ..To assess the Artisan intraocular lens to correct myopia in phakic eyes...
  88. ncbi Direct neural sensory feedback and control of a prosthetic arm
    Gurpreet Singh Dhillon
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    IEEE Trans Neural Syst Rehabil Eng 13:468-72. 2005
    ..We believe this to be the first demonstration of direct neural feedback from and direct neural control of an artificial arm in amputees...
  89. ncbi Comparison of survival and cost-effectiveness between unicondylar arthroplasty and total knee arthroplasty in patients with primary osteoarthritis: a follow-up study of 50,493 knee replacements from the Finnish Arthroplasty Register
    Esa Koskinen
    Orton Orthopedic Hospital, Helsinki, Finland
    Acta Orthop 79:499-507. 2008
    ..We therefore compared the survival of UKA with that of TKA and conducted a cost-benefit analysis comparing UKA with TKA in patients with primary OA...
  90. pmc Total ankle replacement: a population-based study of 515 cases from the Finnish Arthroplasty Register
    Eerik T Skyttä
    COXA Hospital for Joint Replacement, Tampere, Finland
    Acta Orthop 81:114-8. 2010
    ..We evaluated the survival of two TAR designs and factors associated with survival using data from the nationwide arthroplasty registry in Finland...
  91. ncbi The results of the titanium-coated RM acetabular component at 20 years: a long-term follow-up of an uncemented primary total hip replacement
    M Ihle
    Orthopädische Klinik Kassel, Wilhelmshöher Allee 345, D 34131 Kassel, Germany
    J Bone Joint Surg Br 90:1284-90. 2008
    ....
  92. ncbi Radiographic evaluation of a monoblock acetabular component: a multicenter study with 2- to 5-year results
    Thomas A Gruen
    Zonal Concepts, Wesley Chapel, Florida, USA
    J Arthroplasty 20:369-78. 2005
    ....
  93. ncbi Usefulness of a multidetector-row computed tomography scanner for detecting pannus formation
    Hideki Teshima
    Department of Surgery, Kurume University, School of Medicine, Kurume, Japan
    Ann Thorac Surg 77:523-6. 2004
    ..The use of a more advanced diagnostic image, multidetector-row computed tomography scanner, may enable us to determine the anatomic and functional causes of PVD...
  94. ncbi Primary hemiarthroplasty in four-part fractures of the proximal humerus: randomized trial of two different implant systems
    Christian Fialka
    Department of Surgery, Medical University of Vienna, Vienna, Austria
    J Shoulder Elbow Surg 17:210-5. 2008
    ..Accurate placement of the tuberosities and healing at the bone-bone interface of the rotator cuff seem to be the most important factors influencing the outcome in prosthetic care of fractures...
  95. ncbi Standardized incidence rates of total hip replacement for primary hip osteoarthritis in the 5 Nordic countries: similarities and differences
    L Stefan Lohmander
    Department of Orthopaedics, Lund University, Sweden
    Acta Orthop 77:733-40. 2006
    ....
  96. ncbi The PCL significantly affects the functional outcome of total knee arthroplasty
    Michael A Conditt
    Institute of Orthopedic Research and Education, Houston, Texas 77030, USA
    J Arthroplasty 19:107-12. 2004
    ....
  97. ncbi The Harris-Galante porous-coated, hemispherical, polyethylene-lined acetabular component in patients under 50 years of age: a 12- to 16-year review
    M R Utting
    Royal Perth Rehabilitation Hospital, 6 Selby Street, Shenton Park, Western Australia 6008, Australia
    J Bone Joint Surg Br 90:1422-7. 2008
    ..5 to 93.5) and for impending revision 55.3% (95% confidence interval 40.6 to 70) at 16 years. Uncemented acetabular components with polyethylene liners undergo silent lysis and merit regular long-term radiological review...
  98. ncbi The use of targeted muscle reinnervation for improved myoelectric prosthesis control in a bilateral shoulder disarticulation amputee
    T A Kuiken
    Rehabilitation Institute of Chicago, Department of PM and R at Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Prosthet Orthot Int 28:245-53. 2004
    ..Subjectively the patient clearly preferred the new prosthesis. He reported that it was easier and faster to use, and felt more natural...
  99. ncbi Procedural and 30-day outcomes following transcatheter aortic valve implantation using the third generation (18 Fr) corevalve revalving system: results from the multicentre, expanded evaluation registry 1-year following CE mark approval
    Nicolo Piazza
    Thoraxcenter, Rotterdam, The Netherlands
    EuroIntervention 4:242-9. 2008
    ..To describe the procedural performance and 30-day outcomes following implantation using the 18 Fr CoreValve Revalving System (CRS) as part of the multicentre, expanded evaluation registry, 1-year after obtaining CE mark approval...
  100. ncbi Orthopaedic metals and their potential toxicity in the arthroplasty patient: A review of current knowledge and future strategies
    G M Keegan
    University of Bristol, Bristol Implant Research Centre, Avon Orthopaedic Centre lower level, Southmead Hospital, Westbury on Trym, Bristol, BS10 5NB, UK
    J Bone Joint Surg Br 89:567-73. 2007
    ....
  101. pmc A retrospective comparative study of mortality and causes of death among patients with metal-on-metal and metal-on-polyethylene total hip prostheses in primary osteoarthritis after a long-term follow-up
    Tuomo Visuri
    Research Institute of Military Medicine, Helsinki, Finland
    BMC Musculoskelet Disord 11:78. 2010
    ..We analyzed the causes of total and site-specific mortality among a cohort of patients with MM and with metal-on-polyethylene (MP) THA after a long follow-up time...

Research Grants61

  1. A Novel Load Sensing Tibial Prosthesis Design
    DARRYL D LIMA; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  2. Characterizing Ankle Function During Sloped Locomotion For Prosthesis Development
    Alena Grabowski; Fiscal Year: 2012
    ..I also bring together mentors, consultants, and collaborators with extensive expertise in prosthesis design and development, rehabilitation, computer modeling and simulation, and the biomechanics and energetics of ..
  3. Advanced Engineering Development of a Chronic Retinal Implant
    JOHN L contact WYATT; Fiscal Year: 2010
    We propose to develop and improve a novel minimally-invasive retinal prosthesis design. The goal is to restore a limited but useful level of vision to patients blind with retinitis pigmentosa or macular degeneration...
  4. An Exotendon Prosthesis to Improve Walking for Lower Limb Amputees
    BRIAN GLAISTER; Fiscal Year: 2012
    ..In Specific Aim 2 of Phase II, we will further develop the exotendon prosthesis design to provide even greater kinetic and metabolic benefits through the use of non-uniform radii pulleys for both ..
  5. Nanotechnology Enabled Temporomandibular Joint(TMJ)Prosthesis
    RAYMOND G THOMPSON; Fiscal Year: 2012
    ..Commercialization potential for the product will be developed through prosthesis design, prototype wear testing and clinical translation...
  6. Asynchronous glimpsing of speech in the hearing impaired
    EROL JAMES OZMERAL; Fiscal Year: 2013
    ..ability to follow speech in complex backgrounds, with implications for the future of auditory prosthesis design. The training program outlined in the current proposal provides strong mentorship in research design, ..
  7. Electrical Stimulation to Restore Vestibular Function
    CHARLES DELLA SANTINA; Fiscal Year: 2007
    ..by refining a mammalian model of vestibular ototoxicity and by testing the biologic premises upon which prosthesis design is based...
  8. IN VIVO MEASURE VERSUS DYNAMIC ESTIMATE OF HIP FORCE
    Robert Mann; Fiscal Year: 1993
    ..b>Prosthesis design, hip surgery, patient management, rehabilitation protocols, and ADL advice would benefit from precise ..
  9. NEW SMALL VESSEL PROSTHESIS
    Robert Whalen; Fiscal Year: 1990
    ..The composition, structure, and thickness of the PNI from both groups will be compared, and the anastomotic sites will be examined for evidence of diminished intimal hyperplasia resulting from the new prosthesis design.
  10. INTERFACE MECHANICS, MATERIALS AND TISSUE RESPONSE
    Joan Sanders; Fiscal Year: 2007
    ..The development of methods to predict and overcome the detrimental effects of residual limb shape change and ultimately prevent soft-tissue breakdown will help to prevent secondary disability and morbidity in the amputee population. ..
  11. Skin Adaptation to Mechanical Stress
    Joan Sanders; Fiscal Year: 2006
    ..By understanding the process of skin adaptation (natural skin strengthening) at both a cellular and molecular level, therapies to encourage skin adaptation before breakdown occurs can be intelligently pursued. ..
  12. Assessment of Tissue Response to Stress
    Joan Sanders; Fiscal Year: 2006
    ..this technology could be applied to other areas of rehabilitation, for example, shoe design for patients with insensate feet, cushion design for wheelchair users, and mattress design for bedridden patients [unreadable] [unreadable]..
  13. INTERFACE MECHANICS, MATERIALS, AND TISSUE RESPONSE
    Joan Sanders; Fiscal Year: 2003
    ....
  14. INTERFACE MECHANICS, MATERIALS, AND TISSUE RESPONSE
    Joan Sanders; Fiscal Year: 2002
    ....
  15. NEW BIOMATERIALS TO MINIMIZE SCAR TISSUE FORMATION
    Joan Sanders; Fiscal Year: 2002
    ..e. soft-tissue complications that require surgical repair through use of a biomaterial. The new materials will prevent scar tissue formation and reduce the occurrence of secondary complications. ..
  16. Dental Implant Science & Tech Transfer Satellite Meeting
    Jack Lemons; Fiscal Year: 2004
    ..Both organizations, IRG and WCOI-6 have approved the collaborations. Experience has been that 400 or more implant dentists attend the WCOI-6 and i00 or more researchers attend the IRG satellite sessions. ..
  17. Analyses of InSitu and Explanted Surgical Implant Devices
    Jack Lemons; Fiscal Year: 2009
    ..abstract_text> ..
  18. A Novel Waveform for Electrical Nerve Conduction Block
    Kevin Kilgore; Fiscal Year: 2002
    ..The initial intended human application will be to alleviate pain in individuals with neuromas secondary to limb amputation. ..
  19. A Validated Micro-Structural Mechanical Model of Coronary Arteries
    Ghassan S Kassab; Fiscal Year: 2010
    ....
  20. Improving Flow Dynamics in Fontan Surgeries
    Ajit Yoganathan; Fiscal Year: 2006
    ....
  21. Pressure and Flow-Induced Remodeling of Coronary Arteries
    Ghassan S Kassab; Fiscal Year: 2010
    ..The long-term goal of this research is to develop optimal therapies to restore the oxidative balance in CAD. ..
  22. NEURAL REPRESENTATION OF ACOUSTIC ELEMENTS OF SPEECH
    Nina Kraus; Fiscal Year: 2006
    ..Furthermore, the results will delineate the role of neural synchrony in speech perception, and suggest training protocols that may improve speech perception in individuals with impaired hearing mechanisms. ..
  23. A new allograft that promotes long-term, infection-free skeletal repair
    NOREEN J contact HICKOK; Fiscal Year: 2010
    ....
  24. Infusion of Particles at Implant interfeces
    Stuart Goodman; Fiscal Year: 2006
    ..abstract_text> ..
  25. Strain Controlled LVAD Unloading and Post MI Remodeling
    BARTLEY PERRY GRIFFITH; Fiscal Year: 2010
    ..Accordingly, we will learn the impact of controlled strain after large infarction with an interventionally applied micro VAD. ..
  26. Cleveland Clinic Orthopaedic Research Training Grant
    JOSEPH IANNOTTI; Fiscal Year: 2008
    ..abstract_text> ..
  27. Capillary Electrophoresis Profiling of Tears in Dry Eye
    JEAN JACOB; Fiscal Year: 2006
    ....
  28. Osteolysis and Implant Wear: Biological, Biomedical Engineering, and Surgical Pri
    Stuart Goodman; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  29. Annular and Sub-Valvular Repair Techniques for Ischemic Mitral Regurgitation: In-
    Ajit P Yoganathan; Fiscal Year: 2010
    ..abstract_text> ..
  30. EPITHELIALIZATION OF TISSUE ENGINEERED CORNEAS
    JEAN JACOB; Fiscal Year: 2003
    ..The results of these studies will provide insight into the processes involved in the success or failure of corneal augmentation and replacement by artificial implants. ..
  31. Fluid Mechanics of the Mitral Valve: In Vitro Studies
    Ajit Yoganathan; Fiscal Year: 2004
    ..The use of state of the art measurement systems unavailable for in vivo use will yield significant results. ..
  32. CONTROLLED-RELEASE SEALANT TO PREVENT SECONDARY CARIES
    Kenneth Anusavice; Fiscal Year: 2004
    ..mutans, site specific levels of S. mutans at the margins of amalgam and composite restorations, and the width of marginal crevices adjacent to amalgam and composite restorations). ..
  33. EXON-SPECIFIC FIBRONECTIN ISOFORMS AND CHONDROGENESIS
    NOREEN HICKOK; Fiscal Year: 2003
    ..abstract_text> ..
  34. Development of a Spinal Intervertebral Disc Prosthesis
    GLENN BUTTERMANN; Fiscal Year: 2003
    ..The objective of Phase I is to demonstrate that the device restores normal spine biomechanics (range of motion and stiffness) and is durable in fatigue testing. ..
  35. Aerobic Exercise Intervention for Knee Osteoarthritis
    Kenton Kaufman; Fiscal Year: 2005
    ..Hypothesis: A effective exercise prescription for adults with degenerative joint disease is dependent on knee compartment involvement, CIA stage, BMI, and type of exercise prescribed. ..
  36. BIOENGINEERING-BIOLOGIC STUDY OF NON-PULSATILE PERFUSION
    Bartley Griffith; Fiscal Year: 2003
    ..From these experiments, we believe that we will provide significant new information regarding tissue perfusion and arterial adaptation to, and possible impairment from, diminished or non-existent flow pulse. ..
  37. Becoming a member of the CPCRN-for prostatitis
    Richard Berger; Fiscal Year: 2005
    ..Furthermore, the same multidisciplinary focus and experience will allow us the flexibility to design and carry out ancillary studies, which will fit with the overall plan of the CPCRN. ..
  38. Antiproliferative Rx for venous neointimal hyperplasia
    Prabir Roy Chaudhury; Fiscal Year: 2005
    ..We believe that the results from this study could transform the clinical care of hemodialysis patients and at the same time result in the successful clinical application of local therapy for the treatment of neointimal hyperplasia...
  39. BIOENGINEERING-BIOLOGIC STUDY OF NON-PULSATILE PERFUSION
    Bartley Griffith; Fiscal Year: 2002
    ..From these experiments, we believe that we will provide significant new information regarding tissue perfusion and arterial adaptation to, and possible impairment from, diminished or non-existent flow pulse. ..
  40. QUANTIFICATION OF CARTILAGE AND BONE DEFECTS USING MRI
    Chris Mc Gibbon; Fiscal Year: 2002
    ..Hypothesis: the analytical model can predict AC and SB thickness within 1 voxel dimension at a 95 percent confidence level and exhibit defect detection sensitivity and specificity greater than 98 percent. ..
  41. Intracortical Visual Prothesis
    Philip Troyk; Fiscal Year: 2005
    ..6. Establish criteria for proceeding to a future human implantation using a thorough multi-faceted examination of ethical and psychological issues. ..
  42. Intracortical Visual Prothesis
    Philip Troyk; Fiscal Year: 2002
    ..6. Establish criteria for proceeding to a future human implantation using a thorough multi-faceted examination of ethical and psychological issues. ..
  43. DEVELOPMENT OF A CHRONIC ARTIFICIAL LUNG
    Bartley Griffith; Fiscal Year: 2001
    ..5) Develop and validate a closed-loop, flow control algorithm to ensure fail-safe pumping by the CAL spinning disc(s); incorporate algorithm into a controller unit to be part of the overall CAL system. ..
  44. A Novel Waveform for Electrical Nerve Conduction Block
    Kevin L Kilgore; Fiscal Year: 2010
    ..This research will provide a significant tool in our ongoing efforts to reduce disability and improve quality of life. ..
  45. Human Bladder Urothelial Cell Structure and Function in Bladder Hypersensation
    Toby C Chai; Fiscal Year: 2010
    ..By accomplishing these aims, we hope to develop an understanding of the pathogenesis of hypersensory bladder conditions which ultimately can lead to targeted treatment options. ..
  46. Mitral Annular Remodeling for MR Therapy
    Kiyotaka Fukamachi; Fiscal Year: 2005
    ..Therefore, this proposed research program is an important first step in this novel procedure's development as one potential therapeutic option for high-risk CHF patients with functional MR. ..
  47. Bioreactivity Markers in Total Hip Replacments
    Nadim Hallab; Fiscal Year: 2004
    ..Additionally, variable immunologic responses induced by implant degradation products (i.e. lymphocyte response to metal ions and monocyte/macrophage response to particulate debris) will be correlated with the development of osteolysis ..
  48. Motion Sensor Array for Vestibular-deficient Individuals
    Conrad Wall; Fiscal Year: 2005
    ....
  49. Dermatopharmacokinetics: In Vivo Analysis of Solvents
    Karla Thrall; Fiscal Year: 2005
    ..To evaluate the kinetics and dermal bioavailability of ethylbenzene, styrene, and toluene vapor using F344 rats. ..
  50. In Vivo Assessment of AAA Biomechanics with Dynamic Wall Properties
    ENDER FINOL; Fiscal Year: 2008
    ..This methodology is expected to greatly enhance the presurgical planning capabilities of vascular surgeries and endovascular therapies in the future management of cardiovascular diseases. [unreadable] [unreadable] [unreadable]..
  51. Optimizing Hearing Aid Fitting for Older Adults
    Robyn Cox; Fiscal Year: 2007
    ..For these individuals, resources presently allocated to hearing aid purchase would be used more effectively for alternate rehabilitation methods. Outcomes of 100 bilateral hearing aid fittings will be evaluated. [unreadable] [unreadable]..
  52. Effect of Femoral Stem Design om Cement Mantle Failure
    Amos Race; Fiscal Year: 2006
    ..Should these aims be met, the proposed model will be of great use in pre-clinical testing of novel cemented stem designs. ..
  53. Snapshot Retinal Imaging Polarimeter
    James Schwiegerling; Fiscal Year: 2007
    ..Furthermore, the device could potentially be a low-cost add-on to existing fundus cameras, allowing a more widespread utility than existing devices. [unreadable] [unreadable]..
  54. Channel Interaction in Cochlear Implant Subjects
    JULIE BIERER; Fiscal Year: 2004
    ..The results of these studies could influence the development of future cochlear implant electrodes and speech processing strategies, ideally, leading to improved performance for most cochlear implant subjects. ..
  55. Bridge to neonatal Fontan repair of single ventricle
    Mark Rodefeld; Fiscal Year: 2006
    ..abstract_text> ..
  56. Fatigue Crack Morphology in Cemented Hips
    Amos Race; Fiscal Year: 2002
    ....
  57. Motor Control Deficit in Low Back Pain: Cause or Effect?
    Jacek Cholewicki; Fiscal Year: 2003
    ..The results of the proposed research will have a significant clinical relevance for designing more effective prevention, diagnosis, and rehabilitation strategies for LBP. ..
  58. The Mechanism and Function of Lumbosacral Orthoses
    Jacek Cholewicki; Fiscal Year: 2006
    ..In addition, data generated from the proposed research will also carry-over into advancing our understanding of the mechanisms and function of ergonomic lumbar supports. ..