survival analysis

Summary

Summary: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.

Top Publications

  1. pmc Recurrence and outcomes following hepatic resection, radiofrequency ablation, and combined resection/ablation for colorectal liver metastases
    Eddie K Abdalla
    Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Ann Surg 239:818-25; discussion 825-7. 2004
  2. doi Cancer statistics, 2009
    Ahmedin Jemal
    Cancer Surveillance, Surveillance and Health Policy Research, American Cancer Society, Atlanta, Georgia 30303 1002, USA
    CA Cancer J Clin 59:225-49. 2009
  3. ncbi Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    Roger Stupp
    Multidisciplinary Oncology Center, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    N Engl J Med 352:987-96. 2005
  4. ncbi A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer
    Soonmyung Paik
    Division of Pathology, Operation Center, and the Biostatistics Center, National Surgical Adjuvant Breast and Bowel Project, Pittsburgh 15212, USA
    N Engl J Med 351:2817-26. 2004
  5. ncbi Erlotinib in previously treated non-small-cell lung cancer
    Frances A Shepherd
    Department of Medical Oncology, University Health Network, Princess Margaret Hospital Site, University of Toronto, Canada
    N Engl J Med 353:123-32. 2005
  6. doi Sorafenib in advanced hepatocellular carcinoma
    Josep M Llovet
    Barcelona Clinic Liver Cancer Group, Institut d Investigacions Biomediques August Pi i Sunyer, Centro de Investigaciones en Red de Enfermedades Hepáticas y Digestivas Hospital Clínic Barcelona, Barcelona
    N Engl J Med 359:378-90. 2008
  7. ncbi MGMT gene silencing and benefit from temozolomide in glioblastoma
    Monika E Hegi
    Laboratory of Tumor Biology and Genetics, Department of Neurosurgery, University Hospital Lausanne, Lausanne, Switzerland
    N Engl J Med 352:997-1003. 2005
  8. ncbi Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer
    Joan H Schiller
    University of Wisconsin Hospital and Clinics, Madison, USA
    N Engl J Med 346:92-8. 2002
  9. doi Design and endpoints of clinical trials in hepatocellular carcinoma
    Josep M Llovet
    HCC Translational Research Lab, Barcelona Clinic Liver Cancer Group, Liver Unit, Hospital Clinic, CIBERehd, Institute for Biomedical Investigations August Pi Sunyer, Villarroel 170, 08036 Barcelona, Catalonia, Spain
    J Natl Cancer Inst 100:698-711. 2008
  10. ncbi Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2-negative invasive breast cancer, the so-called triple-negative phenotype: a population-based study from the California cancer Registry
    Katrina R Bauer
    Public Health Institute California Cancer Registry, Sacramento, California 95815 4402, USA
    Cancer 109:1721-8. 2007

Detail Information

Publications358 found, 100 shown here

  1. pmc Recurrence and outcomes following hepatic resection, radiofrequency ablation, and combined resection/ablation for colorectal liver metastases
    Eddie K Abdalla
    Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Ann Surg 239:818-25; discussion 825-7. 2004
    ..To examine recurrence and survival rates for patients treated with hepatic resection only, radiofrequency ablation (RFA) plus resection or RFA only for colorectal liver metastases...
  2. doi Cancer statistics, 2009
    Ahmedin Jemal
    Cancer Surveillance, Surveillance and Health Policy Research, American Cancer Society, Atlanta, Georgia 30303 1002, USA
    CA Cancer J Clin 59:225-49. 2009
    ..Further progress can be accelerated by applying existing cancer control knowledge across all segments of the population and by supporting new discoveries in cancer prevention, early detection, and treatment...
  3. ncbi Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    Roger Stupp
    Multidisciplinary Oncology Center, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    N Engl J Med 352:987-96. 2005
    ..In this trial we compared radiotherapy alone with radiotherapy plus temozolomide, given concomitantly with and after radiotherapy, in terms of efficacy and safety...
  4. ncbi A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer
    Soonmyung Paik
    Division of Pathology, Operation Center, and the Biostatistics Center, National Surgical Adjuvant Breast and Bowel Project, Pittsburgh 15212, USA
    N Engl J Med 351:2817-26. 2004
    ..The likelihood of distant recurrence in patients with breast cancer who have no involved lymph nodes and estrogen-receptor-positive tumors is poorly defined by clinical and histopathological measures...
  5. ncbi Erlotinib in previously treated non-small-cell lung cancer
    Frances A Shepherd
    Department of Medical Oncology, University Health Network, Princess Margaret Hospital Site, University of Toronto, Canada
    N Engl J Med 353:123-32. 2005
    ....
  6. doi Sorafenib in advanced hepatocellular carcinoma
    Josep M Llovet
    Barcelona Clinic Liver Cancer Group, Institut d Investigacions Biomediques August Pi i Sunyer, Centro de Investigaciones en Red de Enfermedades Hepáticas y Digestivas Hospital Clínic Barcelona, Barcelona
    N Engl J Med 359:378-90. 2008
    ..A preliminary study suggested that sorafenib, an oral multikinase inhibitor of the vascular endothelial growth factor receptor, the platelet-derived growth factor receptor, and Raf may be effective in hepatocellular carcinoma...
  7. ncbi MGMT gene silencing and benefit from temozolomide in glioblastoma
    Monika E Hegi
    Laboratory of Tumor Biology and Genetics, Department of Neurosurgery, University Hospital Lausanne, Lausanne, Switzerland
    N Engl J Med 352:997-1003. 2005
    ....
  8. ncbi Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer
    Joan H Schiller
    University of Wisconsin Hospital and Clinics, Madison, USA
    N Engl J Med 346:92-8. 2002
    ..We conducted a randomized study to determine whether any of three chemotherapy regimens was superior to cisplatin and paclitaxel in patients with advanced non-small-cell lung cancer...
  9. doi Design and endpoints of clinical trials in hepatocellular carcinoma
    Josep M Llovet
    HCC Translational Research Lab, Barcelona Clinic Liver Cancer Group, Liver Unit, Hospital Clinic, CIBERehd, Institute for Biomedical Investigations August Pi Sunyer, Villarroel 170, 08036 Barcelona, Catalonia, Spain
    J Natl Cancer Inst 100:698-711. 2008
    ..These surrogate markers may help to enrich study populations and maximize the cost-benefit ratio of trial execution. Design and conduct of phase 3 trials should be coordinated by centers with appropriate expertise in HCC...
  10. ncbi Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2-negative invasive breast cancer, the so-called triple-negative phenotype: a population-based study from the California cancer Registry
    Katrina R Bauer
    Public Health Institute California Cancer Registry, Sacramento, California 95815 4402, USA
    Cancer 109:1721-8. 2007
    ..The triple-negative phenotype is important because of its relation to the basal-like subtype of breast cancer...
  11. ncbi Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials
    L Gaspar
    Wayne State University, Detroit, MI 48201, USA
    Int J Radiat Oncol Biol Phys 37:745-51. 1997
    ....
  12. ncbi Unique microRNA molecular profiles in lung cancer diagnosis and prognosis
    Nozomu Yanaihara
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cancer Cell 9:189-98. 2006
    ..These results indicate that miRNA expression profiles are diagnostic and prognostic markers of lung cancer...
  13. ncbi Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival
    Josep M Llovet
    Barcelona Clinic Liver Cancer Group, Liver Unit, Digestive Disease Institut, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Catalonia, Spain
    Hepatology 37:429-42. 2003
    ..In conclusion, chemoembolization improves survival of patients with unresectable HCC and may become the standard treatment. Treatment with tamoxifen does not modify the survival of patients with advanced disease...
  14. ncbi Prognostic factors analysis of 17,600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging system
    C M Balch
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Clin Oncol 19:3622-34. 2001
    ..Thirteen cancer centers and cancer cooperative groups contributed staging and survival data from a total of 30,450 melanoma patients from their databases in order to validate this staging proposal...
  15. ncbi Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma
    Torsten O Nielsen
    Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver Hospital and British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    Clin Cancer Res 10:5367-74. 2004
    ..Currently, there exist clinical assays that identify ER+/luminal and HER2-overexpressing tumors, and we sought to develop a clinical assay for breast basal-like tumors...
  16. ncbi CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma
    Bertrand Coiffier
    Hospices Civils de Lyon and the Université Claude Bernard, Lyons, France
    N Engl J Med 346:235-42. 2002
    ..We conducted a randomized trial to compare CHOP chemotherapy plus rituximab with CHOP alone in elderly patients with diffuse large-B-cell lymphoma...
  17. ncbi Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    Herbert Hurwitz
    Duke University, Durham, NC, USA
    N Engl J Med 350:2335-42. 2004
    ..Bevacizumab, a monoclonal antibody against vascular endothelial growth factor, has shown promising preclinical and clinical activity against metastatic colorectal cancer, particularly in combination with chemotherapy...
  18. ncbi Effect of screening and adjuvant therapy on mortality from breast cancer
    Donald A Berry
    Department of Biostatistics and Applied Mathematics, M D Anderson Cancer Center, Houston, TX 77030, USA
    N Engl J Med 353:1784-92. 2005
    ..We used modeling techniques to assess the relative and absolute contributions of screening mammography and adjuvant treatment to the reduction in breast-cancer mortality in the United States from 1975 to 2000...
  19. ncbi Tutorial in biostatistics: competing risks and multi-state models
    H Putter
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
    Stat Med 26:2389-430. 2007
    ..Examples of analysis with standard software are shown...
  20. ncbi Oncogenic pathway signatures in human cancers as a guide to targeted therapies
    Andrea H Bild
    Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina 27708, USA
    Nature 439:353-7. 2006
    ..Linking pathway deregulation with sensitivity to therapeutics that target components of the pathway provides an opportunity to make use of these oncogenic pathway signatures to guide the use of targeted therapeutics...
  21. ncbi Prognosis of HIV-1-infected patients starting highly active antiretroviral therapy: a collaborative analysis of prospective studies
    Matthias Egger
    Department of Social and Preventive Medicine, University of Bern, CH 3012 Bern, Switzerland
    Lancet 360:119-29. 2002
    ..The ART Cohort Collaboration, which includes 13 cohort studies from Europe and North America, was established to fill this knowledge gap...
  22. doi Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): a randomised phase III trial
    Edward S Kim
    The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Lancet 372:1809-18. 2008
    ..We compared gefitinib with docetaxel in patients with locally advanced or metastatic non-small-cell lung cancer who had been pretreated with platinum-based chemotherapy...
  23. ncbi Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma
    Nicholas J Vogelzang
    University of Chicago, Cancer Research Center, 5841 South Maryland Ave, Chicago, IL 60637, USA
    J Clin Oncol 21:2636-44. 2003
    ..We conducted a phase III trial to determine whether treatment with pemetrexed and cisplatin results in survival time superior to that achieved with cisplatin alone...
  24. ncbi Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    D J Slamon
    Division of Hematology and Oncology, UCLA School of Medicine, Los Angeles, Calif 90095 1678, USA
    N Engl J Med 344:783-92. 2001
    ..The HER2 gene, which encodes the growth factor receptor HER2, is amplified and HER2 is overexpressed in 25 to 30 percent of breast cancers, increasing the aggressiveness of the tumor...
  25. pmc The molecular portraits of breast tumors are conserved across microarray platforms
    Zhiyuan Hu
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    BMC Genomics 7:96. 2006
    ..To overcome this problem we used publicly available breast cancer gene expression data sets and a novel approach to data fusion, in order to validate a new breast tumor intrinsic list...
  26. ncbi Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
    Gary Hudes
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    N Engl J Med 356:2271-81. 2007
    ..Interferon alfa is widely used for metastatic renal-cell carcinoma but has limited efficacy and tolerability. Temsirolimus, a specific inhibitor of the mammalian target of rapamycin kinase, may benefit patients with this disease...
  27. ncbi Cancer statistics, 2002
    Ahmedin Jemal
    Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA, USA
    CA Cancer J Clin 52:23-47. 2002
    ..Despite the continued decline in cancer death rates, the total number of recorded cancer deaths in the United States continues to increase slightly due to the aging and expanding population...
  28. doi Cancer survival in five continents: a worldwide population-based study (CONCORD)
    Michel P Coleman
    Cancer Research UK Cancer Survival Group, Non communicable Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, London, UK
    Lancet Oncol 9:730-56. 2008
    ..This is, to our knowledge, the first worldwide analysis of cancer survival, with standard quality-control procedures and identical analytic methods for all datasets...
  29. ncbi Recent cancer survival in Europe: a 2000-02 period analysis of EUROCARE-4 data
    Arduino Verdecchia
    National Centre for Epidemiology, Health Surveillance and Promotion, Istituto Superiore di Sanita, Rome, Italy
    Lancet Oncol 8:784-96. 2007
    ..We also compared our findings with data on cancer survival in the USA from the US SEER (Surveillance, Epidemiology, and End Results) programme...
  30. ncbi Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors
    George D Demetri
    Dana Farber Cancer Institute and Harvard Cancer Center, Boston, MA 02115, USA
    N Engl J Med 347:472-80. 2002
    ..Imatinib mesylate, a selective tyrosine kinase inhibitor, has been shown in preclinical models and preliminary clinical studies to have activity against such tumors...
  31. ncbi Revised response criteria for malignant lymphoma
    Bruce D Cheson
    Division of Hematology Oncology, Georgetown University Hospital, Washington, DC, USA
    J Clin Oncol 25:579-86. 2007
    ..Standardized response criteria are needed to interpret and compare clinical trials and for approval of new therapeutic agents by regulatory agencies...
  32. pmc Molecular evolution and functional characterization of Drosophila insulin-like peptides
    Sebastian Gronke
    Institute of Healthy Ageing, Department of Genetics, Evolution, and Environment, University College London, London, United Kingdom
    PLoS Genet 6:e1000857. 2010
    ..Evolutionary conservation has thus been accompanied by synergy, redundancy, and functional differentiation between DILPs, and these features may themselves be of evolutionary advantage...
  33. ncbi Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial
    Josep M Llovet
    Liver Unit, Digestive Disease Institute, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Lancet 359:1734-9. 2002
    ..There is no standard treatment for unresectable hepatocellular carcinoma. Arterial embolisation is widely used, but evidence of survival benefits is lacking...
  34. ncbi Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcgammaRIIIa gene
    Guillaume Cartron
    Service d Oncologie Médicale et Maladies du Sang et Laboratoire d Immunologie, Centre Hospitalier Régional et Universitaire de Tours, 37044 Tours Cedex, France
    Blood 99:754-8. 2002
    ..This finding will certainly give rise to new pharmacogenetic approaches to the management of patients with non-Hodgkin lymphomas...
  35. pmc Ovarian carcinoma subtypes are different diseases: implications for biomarker studies
    Martin Köbel
    Department of Pathology, Genetic Pathology Evaluation Centre of the Prostate Research Centre, Vancouver General Hospital and British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    PLoS Med 5:e232. 2008
    ..We examined variation in biomarker expression rates between subtypes, and how this influences correlations between biomarker expression and stage at diagnosis or prognosis...
  36. ncbi Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant
    R A Wolfe
    U S Renal Data System Coordinating Center, Department of Biostatistics, University of Michigan, Ann Arbor 48103, USA
    N Engl J Med 341:1725-30. 1999
    ....
  37. ncbi Phase III study of erlotinib in combination with cisplatin and gemcitabine in advanced non-small-cell lung cancer: the Tarceva Lung Cancer Investigation Trial
    Ulrich Gatzemeier
    Zentrum fur Pneumologie und Thoraxchirurgie, Krankenhaus D LVA, Germany
    J Clin Oncol 25:1545-52. 2007
    ....
  38. ncbi Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection
    Qiang Gao
    Liver Cancer Institute, Zhong Shan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, the Chinese Ministry of Education, Shanghai, People s Republic of China
    J Clin Oncol 25:2586-93. 2007
    ..To investigate the prognostic value of tumor-infiltrating lymphocytes (TILs), especially regulatory T cells (Tregs), in hepatocellular carcinoma (HCC) patients after resection...
  39. ncbi Time-dependent ROC curves for censored survival data and a diagnostic marker
    P J Heagerty
    Department of Biostatistics, University of Washington, Seattle 98195, USA
    Biometrics 56:337-44. 2000
    ....
  40. ncbi Overall C as a measure of discrimination in survival analysis: model specific population value and confidence interval estimation
    Michael J Pencina
    Statistics and Consulting Unit, Department of Mathematics and Statistics, Boston University, 111 Cummington St, MA 02215, USA
    Stat Med 23:2109-23. 2004
    The assessment of the discrimination ability of a survival analysis model is a problem of considerable theoretical interest and important practical applications...
  41. pmc Sleep disordered breathing and mortality: eighteen-year follow-up of the Wisconsin sleep cohort
    Terry Young
    Department of Population Health Sciences, University of Wisconsin Madison, Madison, WI, USA
    Sleep 31:1071-8. 2008
    ..SDB is linked to incident cardiovascular disease, stroke, and other morbidity. However, the risk of mortality with untreated SDB, determined by polysomnography screening, in the general population has not been established...
  42. ncbi A gene-expression signature as a predictor of survival in breast cancer
    Marc J van de Vijver
    Division of Diagnostic Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands
    N Engl J Med 347:1999-2009. 2002
    ..A more accurate means of prognostication in breast cancer will improve the selection of patients for adjuvant systemic therapy...
  43. ncbi Phase III study of docetaxel and cisplatin plus fluorouracil compared with cisplatin and fluorouracil as first-line therapy for advanced gastric cancer: a report of the V325 Study Group
    Eric Van Cutsem
    University Hospital Gasthuisberg, Leuven, Belgium
    J Clin Oncol 24:4991-7. 2006
    ....
  44. pmc Lethal and pre-lethal effects of a fungal biopesticide contribute to substantial and rapid control of malaria vectors
    Simon Blanford
    Center for Infectious Disease Dynamics, Mueller Laboratory, Department of Biology, Penn State University, University Park, Pennsylvania, United States of America
    PLoS ONE 6:e23591. 2011
    ..These results support broadening the current vector control paradigm beyond fast-acting chemical toxins...
  45. ncbi The validity of the diagnosis of acute myocardial infarction in routine statistics: a comparison of mortality and hospital discharge data with the Danish MONICA registry
    Mette Madsen
    National Institute of Public Health, Svanemøllevej 25, DK 2100 Copenhagen, Denmark
    J Clin Epidemiol 56:124-30. 2003
    ..The combination of the national registries was found to be a valid and powerful tool for monitoring the population incidence of MI...
  46. ncbi Long-term results of the R-CHOP study in the treatment of elderly patients with diffuse large B-cell lymphoma: a study by the Groupe d'Etude des Lymphomes de l'Adulte
    P Feugier
    Hematology Department, Centre Hospitalier Universitaire de Brabois, 54500 Vandoeuvre les Nancy, France
    J Clin Oncol 23:4117-26. 2005
    ....
  47. pmc Reductions in malaria and anaemia case and death burden at hospitals following scale-up of malaria control in Zanzibar, 1999-2008
    Maru W Aregawi
    World Health Organization, Global Malaria Programme, 20 Avenue Appia 1211 Geneva 27, Switzerland
    Malar J 10:46. 2011
    ..The impact of the scale-up of insecticide-treated nets (ITN), indoor-residual spraying (IRS) and artemisinin-combination therapy (ACT) combined on malaria burden was assessed at six out of seven in-patient health facilities...
  48. ncbi Serial evaluation of the SOFA score to predict outcome in critically ill patients
    F L Ferreira
    Department of Intensive Care, Erasme University Hospital, Route de Lennik, 808, B 1070 Brussels, Belgium
    JAMA 286:1754-8. 2001
    ..Evaluation of trends in organ dysfunction in critically ill patients may help predict outcome...
  49. ncbi Gemcitabine and cisplatin versus methotrexate, vinblastine, doxorubicin, and cisplatin in advanced or metastatic bladder cancer: results of a large, randomized, multinational, multicenter, phase III study
    H von der Maase
    Aarhus University Hospital, Denmark
    J Clin Oncol 18:3068-77. 2000
    ..Gemcitabine plus cisplatin (GC) and methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) were compared in patients with locally advanced or metastatic transitional-cell carcinoma (TCC) of the urothelium...
  50. pmc Patient retention in antiretroviral therapy programs in sub-Saharan Africa: a systematic review
    Sydney Rosen
    Center for International Health and Development, Boston University School of Public Health, Boston, Massachusetts, United States of America
    PLoS Med 4:e298. 2007
    ..In this paper we present a systematic review of patient retention in ART programs in sub-Saharan Africa...
  51. pmc Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts
    Yudi Pawitan
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Breast Cancer Res 7:R953-64. 2005
    ..Breast cancer expression profiling has so far mainly been used to identify women with a poor prognosis as candidates for adjuvant therapy but without demonstrated value for therapy prediction...
  52. ncbi Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a phase III trial--INTACT 2
    Roy S Herbst
    Department of Thoracic Head and Neck Medical Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 432, Houston, TX 77030, USA
    J Clin Oncol 22:785-94. 2004
    ..This phase III, randomized, placebo-controlled, double-blind trial evaluated gefitinib plus paclitaxel and carboplatin in chemotherapy-naive patients with advanced NSCLC...
  53. ncbi Gastrointestinal stromal tumors: the incidence, prevalence, clinical course, and prognostication in the preimatinib mesylate era--a population-based study in western Sweden
    Bengt Nilsson
    Department of Surgery, The Lundberg Laboratory for Cancer Research, Sahlgrenska Academy at the University of Göteborg, Goteborg, Sweden
    Cancer 103:821-9. 2005
    ..New treatment options mandate more accurate information regarding the incidence, prevalence, clinical behavior, and prognostic factors of GIST...
  54. ncbi Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial--INTACT 1
    Giuseppe Giaccone
    Vrije Universiteit Medical Center, Department of Oncology, De Boelelaan 1117, 1081 Amsterdam, The Netherlands
    J Clin Oncol 22:777-84. 2004
    ..Gefitinib has demonstrated encouraging efficacy in advanced NSCLC in phase II trials in pretreated patients, and a phase I trial of gefitinib in combination with gemcitabine and cisplatin showed favorable tolerability...
  55. ncbi Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck
    Jay S Cooper
    New York University Medical Center, New York, USA
    N Engl J Med 350:1937-44. 2004
    ..We tested the hypothesis that concurrent postoperative administration of cisplatin and radiotherapy would improve the rate of local and regional control...
  56. ncbi Regression models for relative survival
    Paul W Dickman
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Stat Med 23:51-64. 2004
    ....
  57. ncbi The triple negative paradox: primary tumor chemosensitivity of breast cancer subtypes
    Lisa A Carey
    Division of Hematology Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7305, USA
    Clin Cancer Res 13:2329-34. 2007
    ..Gene expression analysis identifies several breast cancer subtypes. We examined the relationship of neoadjuvant chemotherapy response to outcome among these breast cancer subtypes...
  58. ncbi Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
    Edward H Romond
    National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, USA
    N Engl J Med 353:1673-84. 2005
    ..We present the combined results of two trials that compared adjuvant chemotherapy with or without concurrent trastuzumab in women with surgically removed HER2-positive breast cancer...
  59. ncbi Phase III trial of carboplatin and paclitaxel compared with cisplatin and paclitaxel in patients with optimally resected stage III ovarian cancer: a Gynecologic Oncology Group study
    Robert F Ozols
    Medical Science Department, Fox Chase Cancer Center, Philadelphia, PA, USA
    J Clin Oncol 21:3194-200. 2003
    ..Thus, we conducted a noninferiority trial of cisplatin and paclitaxel versus carboplatin and paclitaxel in this population...
  60. ncbi Cancer statistics, 2007
    Ahmedin Jemal
    Cancer Occurrence, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA, USA
    CA Cancer J Clin 57:43-66. 2007
    ..Further progress can be accelerated by supporting new discoveries and by applying existing cancer control knowledge across all segments of the population...
  61. pmc Enhanced infection of liver sinusoidal endothelial cells in a mouse model of antibody-induced severe dengue disease
    Raphaël M Zellweger
    La Jolla Institute for Allergy and Immunology, CA 92037, USA
    Cell Host Microbe 7:128-39. 2010
    ..Antibodies promote massive infection of liver sinusoidal endothelial cells (LSECs), resulting in increased systemic levels of virus. Thus, a subprotective humoral response may, under some circumstances, have pathological consequences...
  62. ncbi Phase III trial of infusional fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) compared with infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) as first-line treatment for metastatic colorectal cancer: the Gruppo Oncologico Nor
    Alfredo Falcone
    U O Oncologia Medica, Istituto Toscano Tumori, Livorno, Italy
    J Clin Oncol 25:1670-6. 2007
    ....
  63. ncbi Intraperitoneal cisplatin and paclitaxel in ovarian cancer
    Deborah K Armstrong
    Johns Hopkins Kimmel Cancer Center, Baltimore, USA
    N Engl J Med 354:34-43. 2006
    ..The Gynecologic Oncology Group conducted a randomized, phase 3 trial that compared intravenous paclitaxel plus cisplatin with intravenous paclitaxel plus intraperitoneal cisplatin and paclitaxel in patients with stage III ovarian cancer...
  64. ncbi Chemoradiotherapy of locally advanced esophageal cancer: long-term follow-up of a prospective randomized trial (RTOG 85-01). Radiation Therapy Oncology Group
    J S Cooper
    Department of Radiation Oncology, New York University, NY, USA
    JAMA 281:1623-7. 1999
    ..We previously reported results of a study conducted from January 1986 to April 1990 of combined chemotherapy and RT vs RT alone when an interim analysis revealed significant benefit for combined therapy...
  65. doi EUROCARE-4. Survival of cancer patients diagnosed in 1995-1999. Results and commentary
    Milena Sant
    Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Eur J Cancer 45:931-91. 2009
    ..For all cancers, 5-year survival conditional to surviving 1-year was higher and varied less with region, than the overall relative survival...
  66. ncbi Central nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast carcinoma
    Johanna C Bendell
    Department of Adult Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cancer 97:2972-7. 2003
    ..Women with HER-2 overexpressing metastatic breast carcinoma benefit from trastuzumab-based therapy, but trastuzumab does not cross the blood-brain barrier. The authors characterized central nervous system (CNS) disease in these women...
  67. pmc Ki-67 as prognostic marker in early breast cancer: a meta-analysis of published studies involving 12,155 patients
    E de Azambuja
    Medical Oncology Clinic, Jules Bordet Institute, 125 Boulevard de Waterloo, 1000, Brussels, Belgium
    Br J Cancer 96:1504-13. 2007
    ..65-3.91); P<0.001) and node-positive patients (HR=2.33 (95% CI: 1.83-2.95); P<0.001). Our meta-analysis suggests that Ki-67/MIB-1 positivity confers a higher risk of relapse and a worse survival in patients with early BC...
  68. ncbi Preoperative versus postoperative chemoradiotherapy for rectal cancer
    Rolf Sauer
    Department of Radiation Therapy, University of Erlangen, Erlangen, Germany
    N Engl J Med 351:1731-40. 2004
    ..In recent years, encouraging results with preoperative radiotherapy have been reported. We compared preoperative chemoradiotherapy with postoperative chemoradiotherapy for locally advanced rectal cancer...
  69. ncbi Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
    Jerome Galon
    INSERM U 255, Paris, 75006 France Université Paris Descartes Paris 5, Faculte de Medecine, Paris, 75006 France
    Science 313:1960-4. 2006
    ..In situ analysis of tumor-infiltrating immune cells may therefore be a valuable prognostic tool in the treatment of colorectal cancer and possibly other malignancies...
  70. ncbi DNA synthesis and repair genes RRM1 and ERCC1 in lung cancer
    Zhong Zheng
    From the Division of Thoracic Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL
    N Engl J Med 356:800-8. 2007
    ..RRM1, the regulatory subunit of ribonucleotide reductase, is involved in carcinogenesis, tumor progression, and the response of non-small-cell lung cancer to treatment...
  71. ncbi Multiple imputation of missing blood pressure covariates in survival analysis
    S van Buuren
    TNO Prevention and Health, Department of Statistics, Leiden, The Netherlands
    Stat Med 18:681-94. 1999
    This paper studies a non-response problem in survival analysis where the occurrence of missing data in the risk factor is related to mortality...
  72. ncbi Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure
    Gust H Bardy
    Seattle Institute for Cardiac Research, Seattle, WA 98103, USA
    N Engl J Med 352:225-37. 2005
    ..Treatment with amiodarone or an implantable cardioverter-defibrillator (ICD) has been proposed to improve the prognosis in such patients...
  73. ncbi Randomized trial of radiation therapy versus concomitant chemotherapy and radiation therapy for advanced-stage oropharynx carcinoma
    G Calais
    G Calais, Centre Hospitalier Universitaire Tours, France
    J Natl Cancer Inst 91:2081-6. 1999
    ..e., advanced oropharynx carcinoma)...
  74. ncbi Gene expression profiling of primary cutaneous melanoma and clinical outcome
    Veronique Winnepenninckx
    Department of Pathology, Gustave Roussy Institute, 94805 Villejuif Cedex, France
    J Natl Cancer Inst 98:472-82. 2006
    ..To identify differentially expressed genes that may be involved in melanoma progression and prognosis, we investigated the relationship between gene expression profiles and clinical outcome in a cohort of patients with primary melanoma...
  75. ncbi Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease
    Peter M A Calverley
    University Hospital Aintree, Liverpool, United Kingdom
    N Engl J Med 356:775-89. 2007
    ..Long-acting beta-agonists and inhaled corticosteroids are used to treat chronic obstructive pulmonary disease (COPD), but their effect on survival is unknown...
  76. ncbi International uniform response criteria for multiple myeloma
    B G M Durie
    Aptium Oncology, Inc, Cedars Sinai Outpatient Cancer Center, Los Angeles, CA 90048, USA
    Leukemia 20:1467-73. 2006
    ..It is anticipated that the International Response Criteria for multiple myeloma will be widely used in future clinical trials of myeloma...
  77. ncbi Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention
    Mark J Sarnak
    Circulation 108:2154-69. 2003
  78. doi An improved comorbidity index for outcome analyses among dialysis patients
    Jiannong Liu
    United States Renal Data System Coordinating Center, 914 South 8th Street, Minneapolis, MN 55404, USA
    Kidney Int 77:141-51. 2010
    ..Our index performance was almost identical to the individual comorbid conditions regarding model fit, predictive ability, and effect on inference, and it outperformed the widely used Charlson Comorbidity Index...
  79. ncbi Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer
    Marshall R Posner
    Dana Farber Cancer Institute, Boston, MA 02115, USA
    N Engl J Med 357:1705-15. 2007
    ....
  80. ncbi Chemotherapy with preoperative radiotherapy in rectal cancer
    Jean Francois Bosset
    Department of Radiation Therapy, University of Franche Comte, Besancon, France
    N Engl J Med 355:1114-23. 2006
    ..Preoperative radiotherapy is recommended for selected patients with rectal cancer. We evaluated the addition of chemotherapy to preoperative radiotherapy and the use of postoperative chemotherapy in the treatment of rectal cancer...
  81. pmc Estimates of child deaths prevented from malaria prevention scale-up in Africa 2001-2010
    Thomas P Eisele
    Department of Global Health Systems and Development, Tulane University School of Public Health and Tropical Medicine, 1440 Canal Street, Suite 2200, New Orleans, LA 70112, USA
    Malar J 11:93. 2012
    ....
  82. ncbi Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib
    David A Eberhard
    Department of Pathology, Genentech Inc, San Francisco, CA, USA
    J Clin Oncol 23:5900-9. 2005
    ..KRAS is frequently activated in NSCLC. The relationship of KRAS mutations to outcome after EGFR inhibitor treatment has not been described...
  83. ncbi Flexible parametric proportional-hazards and proportional-odds models for censored survival data, with application to prognostic modelling and estimation of treatment effects
    Patrick Royston
    Cancer Division, MRC Clinical Trials Unit, 222 Euston Road, London NW1 2DA, UK
    Stat Med 21:2175-97. 2002
    ..The tools described here may be a step towards providing greater insight into the natural history of the disease and into possible underlying causes of clinical events. We illustrate these aspects by using the two examples in cancer...
  84. pmc Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary
    Ahmed Ashour Ahmed
    Functional Genomics of Ovarian Cancer Laboratory, Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK
    J Pathol 221:49-56. 2010
    ..Because TP53 mutation is almost invariably present in HGPSC, it is not of substantial prognostic or predictive significance...
  85. doi A comparison of inflammation-based prognostic scores in patients with cancer. A Glasgow Inflammation Outcome Study
    Michael J Proctor
    University Department of Surgery, Faculty of Medicine, University of Glasgow, Royal Infirmary, Glasgow, UK
    Eur J Cancer 47:2633-41. 2011
    ..The aim of the present study was to compare the prognostic value of these scores...
  86. ncbi Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer
    Arlene A Forastiere
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231 1000, USA
    N Engl J Med 349:2091-8. 2003
    ..The value of adding chemotherapy to radiotherapy and the optimal timing of chemotherapy are unknown...
  87. ncbi Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer
    Lin Zhang
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia 19104, USA
    N Engl J Med 348:203-13. 2003
    ..Although tumor-infiltrating T cells have been documented in ovarian carcinoma, a clear association with clinical outcome has not been established...
  88. pmc Repeated observation of breast tumor subtypes in independent gene expression data sets
    Therese Sorlie
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 100:8418-23. 2003
    ..Our results strongly support the idea that many of these breast tumor subtypes represent biologically distinct disease entities...
  89. ncbi A molecular signature of metastasis in primary solid tumors
    Sridhar Ramaswamy
    Whitehead Institute MIT Center for Genome Research, One Kendall Square, Building 300, Cambridge, Massachusetts 02139, USA
    Nat Genet 33:49-54. 2003
    ..These results suggest that the metastatic potential of human tumors is encoded in the bulk of a primary tumor, thus challenging the notion that metastases arise from rare cells within a primary tumor that have the ability to metastasize...
  90. pmc Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses
    Jianhua Sui
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street JFB 826, Boston, Massachusetts 02115, USA
    Nat Struct Mol Biol 16:265-73. 2009
    ..Our data further suggest that this region is recalcitrant to neutralization escape and that nAb-based immunotherapy is a promising strategy for broad-spectrum protection against seasonal and pandemic influenza viruses...
  91. ncbi Factors predictive of survival among 337 patients with mesothelioma treated between 1984 and 1994 by the Cancer and Leukemia Group B
    J E Herndon
    CALGB Statistical Center, Department of Community and Family Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Chest 113:723-31. 1998
    ..To examine the individual and joint effect of various pretreatment clinical characteristics on the survival of patients with mesothelioma treated by the Cancer and Leukemia Group B (CALGB)...
  92. pmc Regional variation in out-of-hospital cardiac arrest incidence and outcome
    Graham Nichol
    Department of Biostatistics, University of Washington Clinical Trial Center, Seattle, WA, USA
    JAMA 300:1423-31. 2008
    ..The health and policy implications of regional variation in incidence and outcome of out-of-hospital cardiac arrest remain to be determined...
  93. ncbi Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
    David Cunningham
    Royal Marsden Hospital, London, United Kingdom
    N Engl J Med 351:337-45. 2004
    ..We compared the efficacy of cetuximab in combination with irinotecan with that of cetuximab alone in metastatic colorectal cancer that was refractory to treatment with irinotecan...
  94. ncbi The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital
    Matthew A Borgman
    Brooke Army Medical Center, Fort Sam Houston, TX, USA
    J Trauma 63:805-13. 2007
    ..The risk of death from hemorrhagic shock increases in this population. To treat the coagulopathy of trauma, some have suggested early, aggressive correction using a 1:1 ratio of plasma to red blood cell (RBC) units...
  95. doi MicroRNA classifiers for predicting prognosis of squamous cell lung cancer
    Mitch Raponi
    Centocor Research and Development, Radnor, Pennsylvania 19087, USA
    Cancer Res 69:5776-83. 2009
    ..Our data indicate that miRNAs may have greater clinical utility in predicting the prognosis of patients with squamous cell lung carcinomas than mRNA-based signatures...
  96. ncbi A comparison of rate control and rhythm control in patients with atrial fibrillation
    D G Wyse
    AFFIRM Clinical Trial Center, Axio Research, 2601 4th Ave, Ste 200, Seattle, WA 98121, USA
    N Engl J Med 347:1825-33. 2002
    ..In both approaches, the use of anticoagulant drugs is recommended...
  97. ncbi Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial
    Amar Gajjar
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Lancet Oncol 7:813-20. 2006
    ..We aimed to investigate the effectiveness of risk-adapted radiotherapy followed by a shortened period of dose-intense chemotherapy in children with medulloblastoma...
  98. ncbi Prognosis of cancers associated with venous thromboembolism
    H T Sørensen
    Department of Clinical Epidemiology, Aarhus University Hospital, Denmark
    N Engl J Med 343:1846-50. 2000
    ..Little is known about the prognosis of cancer discovered during or after an episode of venous thromboembolism...
  99. ncbi European system for cardiac operative risk evaluation (EuroSCORE)
    S A Nashef
    Papworth Hospital, Cambridge, UK
    Eur J Cardiothorac Surg 16:9-13. 1999
    ..To construct a scoring system for the prediction of early mortality in cardiac surgical patients in Europe on the basis of objective risk factors...
  100. doi L1 penalized estimation in the Cox proportional hazards model
    Jelle J Goeman
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
    Biom J 52:70-84. 2010
    ..An R package, penalized, that implements the method, is available on CRAN...
  101. ncbi Systematic review of microsatellite instability and colorectal cancer prognosis
    S Popat
    MRCP, Institute of Cancer Research, Brookes Lawley Building, Sutton, Surrey SM2 5NG, UK
    J Clin Oncol 23:609-18. 2005
    ..To derive a more precise estimate of the prognostic significance of MSI, we have reviewed and pooled data from published studies...

Research Grants77

  1. Bone Deficits and Excess Adiposity after Pediatric Bone Marrow Transplantation
    Sogol Mostoufi-Moab; Fiscal Year: 2013
    ..g. longitudinal data analysis, clinical trial design, and survival analysis), (2) participation in the Childhood Cancer Survivor Study working groups for research activity, and (3) ..
  2. Geriatric Conditions and Disablement in the Older Adult Population
    Christine T Cigolle; Fiscal Year: 2013
    ..including longitudinal analysis, latent trajectory analysis, hierarchical linear modeling, and survival analysis via tutorials with mentors and classwork through the Institute for Social Research and School of Public ..
  3. Mouse Models of Non-Syndromic Cardiac Progeria
    Ali J Marian; Fiscal Year: 2012
    ..We will assess survival by Kaplan-Meier survival analysis;cardiac structure and function by echocardiography;and conduction defects and arrhythmias by ..
  4. Patient-centered approaches to diagnosing coronary heart disease
    JOSEPH ABIODUN LADAPO; Fiscal Year: 2013
    ..constitute a combination of quantitative and qualitative training, including epidemiological training in survival analysis, clinical informatics training to leverage the powerful tool of EHR for research, qualitative methods in the ..
  5. Impact of Microparticles on Oral TSE Infections
    Joel A Pedersen; Fiscal Year: 2012
    ..b>Survival analysis of oral transmission experiments demonstrate that prions bound to clay are approximately 700 times more ..
  6. Evaluation of In Vitro Companion Diagnostic Monoclonal Antibodies for Use in a St
    Christopher Horvath; Fiscal Year: 2013
    ..invasiveness, vascularity), c) correlate DEspR expression with Oncotype DX" recurrence scores and survival analysis, and d) select the preferred CDx mAb;3) to design a preliminary CDx IHCS scoring system to stratify DEspR+ ..
  7. Risk of death among veterans with depression
    Kara Zivin; Fiscal Year: 2013
    ..We will use survival analysis techniques, specifically Cox regression models, as well as logistic regression analysis to examine the ..
  8. Cardiovascular and Prostatic Safety of Testosterone Therapy in Aging Males
    Stephen K Van Den Eeden; Fiscal Year: 2013
    ..Standard survival analysis techniques will be used to examine testosterone replacement therapy in relation to each event of interest (..
  9. Frailty Models and Survival Analysis in Cancer Research
    Jason Fine; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): The proposal's objective is to develop practicable survival analysis tools for clinical, epidemiologic, and basic science studies in oncology and other chronic diseases in the health sciences...
  10. Genome wide association study of breast cancer subtype and survival in Latinas
    Laura Fejerman; Fiscal Year: 2013
    ..Fejerman to acquire the training necessary to perfect her skills in genetic data analysis, to conduct survival analysis, to design studies with primary data collection, to obtain teaching experience, and to write competitive ..
  11. Gendered Social Context of Adolescent HIV Risk Behavior in Ghana
    Jeffrey B Bingenheimer; Fiscal Year: 2013
    ..Analytic strategies include generalized confirmatory factor analysis, growth curve modeling, survival analysis, propensity stratification, and latent class modeling to answer specific research questions...
  12. Identification of Persistent Impairments in Postural Control Following Concussion
    GEORGE W SHAVER; Fiscal Year: 2011
    ..of locomotion, and ground reaction forces will be compared both within and between subjects utilizing survival analysis. We hypothesize, supported by our preliminary data, that GI, gait, and GT will identify impairments in ..
  13. TRAINING IN THE EPIDEMIOLOGY OF AGING
    Anne B Newman; Fiscal Year: 2013
    ..foundation in traditional epidemiologic methods and quantitative skills with emphasis on longitudinal and survival analysis, evaluation of heterogeneity and confounding by comorbidity and polypharmacy, assessment of functional ..
  14. Biodemography of Disease and Death in Moscow
    James W Vaupel; Fiscal Year: 2010
    ..years after the first interview and to study these longitudinal data, using standard statistical methods of survival analysis, with a focus on determining the incremental value of Holter information to predict morbidity and mortality...
  15. Genes Related to HCC Progression in LD and DD Transplant
    Robert A Fisher; Fiscal Year: 2010
    ..established in aim 2 will be studied for it's accuracy to predict outcomes post-LT by performing survival analysis and comparing the risk of post-LT HCC recurrence stratified by LDLT and Deceased Donor ...
  16. Korean Immigrants & Mammography-Culture-Specific Health Intervention (KIM-CHI)
    Eunice E Lee; Fiscal Year: 2010
    ..obtained (0, 1, or 2) and if obtained, length of time to obtain the first mammogram, at 15 months using survival analysis;(2) compare the two groups on the mediating variables of health beliefs, knowledge, self-efficacy, spousal ..
  17. Clinical and Behavioral Determinants of CKD Disparities
    LEIGH E BOULWARE; Fiscal Year: 2010
    ..Analytic methods will include logistic regression, survival analysis, analysis of clustered data, and other longitudinal data analysis techniques...
  18. Prognostic Markers for HIV-Postive Diffuse Large B-Cell Lymphoma
    Chun R Chao; Fiscal Year: 2011
    ..Analytical techniques including survival analysis and logistic regression will be used to analyze data for the proposed aims...
  19. Regional Variability in Inpatient Rehabilitation among Medicare Beneficiaries
    Timothy Reistetter; Fiscal Year: 2013
    ..skills for examining rehabilitation outcomes through the study of epidemiology, multilevel analysis, and survival analysis;4) Broaden collaboration with other researchers in health services, epidemiology and public health and ..
  20. Down Syndrome in Massachusetts: A population-based study of early childhood healt
    Eugene Declercq; Fiscal Year: 2011
    ..National Death Index data will strengthen the survival analysis. Extensive information from Early Intervention (EI) will be used to more fully characterize developmental ..
  21. Forging a road to personalized medicine in interstitial lung diseases
    Kevin R Flaherty; Fiscal Year: 2013
    ..data, high throughput molecular, genetic, and epigenetic data, and advanced concepts in clinical trials and survival analysis. I will continue my training i the responsible conduct of research through institutional review board ..
  22. Ethnic Differences in the Risk of Fracture and Vascular Disease
    Jeffrey R Curtis; Fiscal Year: 2011
    ..b>Survival analysis will compare rates and risk factors for first and recurrent fractures and vascular events by ethnicity/race ..
  23. Basic mechanisms in arteriovenous fistula maturation for hemodialysis
    EUGENE SANGKEU LEE; Fiscal Year: 2013
    ..monocyte transendothelial migration and endothelial permeability 7 Biostatistics: Multivariate analysis and survival analysis (vein maturation and duration) 7 Patient management and case report form management...
  24. Estrogen receptor beta protein:protein interactions following estrogen withdrawal
    NATASHA MOTT; Fiscal Year: 2013
    ..Despite the mean age for women experiencing menopause being 51 years (according to the Kaplan-Meier survival analysis), some women involved in the WHI study were, on average, 11-12 years post-menopause...
  25. Developing and Validating a Veterans Affairs Cardiac Risk Score
    Rodney A Hayward; Fiscal Year: 2013
    ..The REG models will be developed using Weibull survival analysis and the ML models will primarily use random forest ML methods (Aim 1)...
  26. Impact of Lifestyle with Tumor Pathways and Microenvironment on Lymphoma Survival
    ANDREW M contact EVENS; Fiscal Year: 2010
    ..of lifestyle factors and tumor molecular markers with NHL survival will be evaluated using standard survival analysis. Because the study population is well-characterized and extensive epidemiologic and follow-up data as well ..
  27. Trial of Minocycline to Reduce Pain after A1 Pulley and Carpal Tunnel Release
    CATHERINE MILLS CURTIN; Fiscal Year: 2012
    ..We plan to explicitly study pain chronicity by using TPR as our primary endpoint and survival analysis to identify predictors of transitioning from acute to chronic pain...
  28. Acute Lung Injury: Application of Novel Approaches to Longitudinal Data Analysis
    WILLIAM N CHECKLEY; Fiscal Year: 2010
    ..one event as an incomplete observation for the other violates the assumptions of standard methods in survival analysis, does not describe the realities of critical care outcomes, and only provides a limited view of the ..
  29. Race, pathomolecular signature and colorectal cancer survival
    Kristin Wallace; Fiscal Year: 2013
    ..In Aim 2, building on Aim 1, we will perform a survival analysis in a cohort of CRC patients to examine the joint influence of race and pathologic and molecular prognostic ..
  30. Acute Lung Injury: Application of Novel Approaches to Longitudinal Data Analysis
    WILLIAM N CHECKLEY; Fiscal Year: 2013
    ..one event as an incomplete observation for the other violates the assumptions of standard methods in survival analysis, does not describe the realities of critical care outcomes, and only provides a limited view ofthe ..
  31. Fertility desire and pregnancy in a cohort of discordant Ugandan couples on ART
    ANGELA KANANA KAIDA; Fiscal Year: 2012
    ..Log-linear and survival analysis methods (with a generalized estimating equation extension) will be used to model predictors of the primary ..
  32. Training Program in Biostatistics for Cancer Research
    Marina Vannucci; Fiscal Year: 2013
    ..With faculty expertise in Bayesian methods, decision theory, cancer clinical trials, cancer screening, survival analysis, statistical genetics, genomics, bioinformatics, and statistical computing, trainees will receive a broad ..
  33. Pharmacogenetics of Warfarin in Puerto Rican Patients using a Physiogenomics Appr
    Jorge Duconge; Fiscal Year: 2013
    ..obtained CYP2C9 and VKORC1 genotypes and the corresponding time to achieve stable warfarin dosing following survival analysis techniques and Cox proportional hazards model...
  34. Linking Cessation &Prevention to Stop Intergenerational Transmission of Smoking
    Christine Jackson; Fiscal Year: 2013
    ..b>Survival analysis will test the effects of the intervention on initiation of smoking among children and on maintenance of ..
  35. Retrospective cohort study of racial disparities in HIV survival, Florida
    Mary Jo Trepka; Fiscal Year: 2013
    ..b>Survival analysis using Cox Proportional Hazards and multilevel models will be conducted...
  36. Techniques for modeling complex longitidinal studies
    John P Klein; Fiscal Year: 2010
    ..2. To continue our investigation into methods for multistate and multivariate survival analysis. We plan to continue our development of techniques for direct modeling and inference for the probability a ..
  37. Nephrotic Syndrome, Cardiovascular Disease Risk and the Effect of Statin Therapy
    Laura H Mariani; Fiscal Year: 2012
    ..We will perform a survival analysis, using a Cox proportional hazards model, to determine the hazard ratio for cardiovascular events, and then ..
  38. Predictors of Pathological Gambling among African-American Young Adults
    Silvia Saboia Martins; Fiscal Year: 2012
    ..b>Survival analysis, Latent Transition Analyses and Generalized Estimating Equations (GEE) will identify distinctive features of ..
  39. Flexible Statistical Methods for Complex Survival Data in Biomedical Studies
    Wenbin Lu; Fiscal Year: 2013
    ..Thus, they play important roles in many biomedical applications by offering comprehensive survival analysis. We seek to develop statistically sound methods that not only make proper use of data information and ..
  40. Real Time Data Collection with Adaptive Sampling and Innovative Technologies
    STEPHEN L RATHBUN; Fiscal Year: 2013
    ..fitting that we propose to develop is anticipated to be broadly applicable not only to EMA, but also to survival analysis in biomedicine, spatial epidemiology in environmental health, and to event history data in the social and ..
  41. The germline variation in immune and epigenetic pathways and melanoma prognosis
    Tomas Kirchhoff; Fiscal Year: 2013
    ..In the proposed design we plan to perform a genotyping and survival analysis using a Cox model of >400 common variants in 154 genes from immunomodulatory and epigenetic pathways ..
  42. Religious engagement and psychopathology over the lifecourse
    Joanna Maselko; Fiscal Year: 2009
    ..Using survival analysis techniques, we will analyze data from three follow-up studies of the New England Cohorts of the National ..
  43. Hypoglycemia in Children and Adolescents with T1DM: Mechanisms and Prevention
    Nelly Mauras; Fiscal Year: 2011
    ..Statistical analyses will include multivariate analyses of variance, survival analysis and individual growth modeling techniques...
  44. Examining several possible causes of GxE non-replications in depression
    Suzanne Vrshek-Schallhorn; Fiscal Year: 2012
    ..abstract_text> ..
  45. Commonly Used Medications and Risk of Colorectal Cancer Recurrence
    Jessica Chubak; Fiscal Year: 2013
    ..A variety of well-established methods will be used to control for confounding in survival analysis to produce estimates of the relative risk of recurrence associated with common medications...
  46. Opioid Use, Physical Function, Falls, and Fracture in Older Men
    ERIN ELIZABETH KREBS; Fiscal Year: 2013
    ..Associations between opioid use and incident clinical fractures will be examined using survival analysis to model time to first fracture (aim 2) Geriatric risk factors and their interactions with analgesic ..
  47. Alcohol Involvement in a Cohort of Trauma Patients: Trends and Future Mortality
    GORDON STEPHEN SMITH; Fiscal Year: 2013
    ..b>Survival analysis will be used to evaluate the extent to which elevated BACs on admission predict subsequent mortality from ..
  48. Acupuncture for Dysphagia after Chemoradiation for Head and Neck Cancer
    Weidong Lu; Fiscal Year: 2011
    ..strengthen his statistical and analytic skills, including those related to meta-analysis, outcomes research, survival analysis and biomarkers in oncology;and 3) improve his substantive knowledge of clinical oncology, especially of HNC...
  49. Statistical Methods for Predicting Sucicide Attempt
    HANGA CSILLA GALFALVY; Fiscal Year: 2010
    ..Aim 2 will build/evaluate survival analysis models when some of the subjects have censored data...
  50. Optimizing Care for Older Adults with Back Pain and Depression
    Jordan F Karp; Fiscal Year: 2013
    ..b>Survival analysis will be used to compare response rates and time to response for the treatment conditions...
  51. Method Development for Survival Dynamic Regression in Chronic Disease Research
    Limin Peng; Fiscal Year: 2013
    ..of this grant have demonstrated that varying coefficient regression, termed as dynamic regression in survival analysis (Martinussen and Scheike, 2006), provides a powerful tool for discovering important changes in associations ..
  52. Alcohol Effects on Cognitive &Affective Mediation of Women's Decision Making
    Jeanette Norris; Fiscal Year: 2013
    ..Background and situational models will be examined using longitudinal data analytic techniques, including survival analysis, latent transition analysis, and growth curve modeling.
  53. Individualized Objective Techniques for Early Detection of Ototoxicity
    MARILYN FARNSWORTH contact DILLE; Fiscal Year: 2011
    ..Aim #3 will be evaluated using discrete-time survival analysis to predict the risk of hearing change over the course of treatment as a function of baseline OAE ..
  54. Interactions among Depressive Symptoms and Genetic Influences on Cardiac Outcomes
    Lorraine Q Frazier; Fiscal Year: 2011
    ..Occurrence of MACE will be followed for 2 years. Data will be analyzed using logistic regression and survival analysis.
  55. Effective clustering penalized methods for genomic biomarker selection
    Shuangge Ma; Fiscal Year: 2010
    ..3] Cancer survival analysis using proposed clustering penalized approaches, where the outcome is censored survival time...
  56. DEterminants of Timely Evaluation Colonoscopy for crc+ screening Tests
    Melissa R Partin; Fiscal Year: 2013
    ..recommendations regarding which CDE barriers to target in future improvement efforts;and (3) use survival analysis techniques to estimate the relative contribution to CDE rate estimates of: patient refusal, outside ..
  57. Initiation and Progression through Early Drinking Milestones in Underage Drinkers
    KRISTINA MELIA JACKSON; Fiscal Year: 2012
    ..aims will be addressed primarily using techniques of item response theory modeling, multilevel modeling, survival analysis, latent growth modeling, and latent transition analysis...
  58. Pain & Pain Management in a Medicaid Waiver Program
    BETH BYMA; Fiscal Year: 2010
    ..Generalized Estimating Equations, logistic regression and survival analysis methods will be used to test hypotheses generated from study aims...
  59. Linking transmission models and data analysis in infectious disease epidemiology
    Eben Kenah; Fiscal Year: 2010
    ..We will then adapt methods from survival analysis to likelihoods derived from transmission models to develop methods for point estimation and hypothesis ..
  60. Mediation in survival and onset-to-growth models applied to youth substance onset
    AMANDA JANE FAIRCHILD; Fiscal Year: 2013
    ..models developed and evaluated in the first phase involve the integration of mediation with discrete-time survival analysis tested through: (a) a series of statistical simulations to evaluate empirical power, Type 1 error rates, ..
  61. Semiparametric Bayesian Survival Analysis
    Debajyoti Sinha; Fiscal Year: 2010
    ..New and existing methods will be evaluated and compared using analysis of mainly cancer studies data from the published literature and from other sources such as the MUSC Hoolings Cancer Center. ..
  62. Residential mobility and young children: Family, neighborhoods, and well-being
    Mary Clare Lennon; Fiscal Year: 2010
    ..Using various analytic techniques, including growth curve modeling and survival analysis, we propose that the impact of residential mobility on child well-being varies with the quality of family ..
  63. Campylobacter colonization and virulence determinants
    Alain Stintzi; Fiscal Year: 2007
    ..C. jejuni colonization and virulence determinants will be identified by in vitro and in vivo survival analysis of insertional mutants using DNA microarray...
  64. PROSPECTIVE STUDY OF HEALTH IN RUNNERS AND WALKERS
    Paul Williams; Fiscal Year: 2002
    ..b>Survival analysis will be used to test for a dose-response relationship between running mileage and CHD and cancer risk, and ..
  65. Clinical Prediction rule for Pelvic Fracture Hemorrage
    C Blackmore; Fiscal Year: 2004
    ..formal coursework and informal mentoring focused on: 1) advanced techniques in data analysis, particularly survival analysis, and epidemiological methods for clinical prediction rules; 2) multi- institutional research design, ..
  66. THE BIODEMOGRAPHY OF HUMAN LONGEVITY--A TRAINING PROGRAM
    Leonid Gavrilov; Fiscal Year: 2005
    ..acquire enhanced research analytical skills in familial data analysis (event history analysis, multivariate survival analysis, multilevel modeling, population genetics), to strengthen his biosocial background and broaden his ..
  67. Aspiration Pneumonia in Children with Neurological Impairment
    Rajendu Srivastava; Fiscal Year: 2009
    ..g., clinical trials, survival analysis modeling), quality of life measurement, and the design and execution of multi-site studies...
  68. BALTIMORE NEEDLE EXCHANGE PROGRAM EVALUATION
    Steffanie Strathdee; Fiscal Year: 2004
    ..To meet Aim 1, comparisons of NEP attenders vs. non-attenders will be conducted using survival analysis and Poisson regression...
  69. Time to Neonatal and postneonatal death US 1985-1995
    AMANDA LIDDLE; Fiscal Year: 2000
    ..The study will accomplish these aims by using survival analysis (log lgostic), and logistic regression on three secondary data sets: US and South Carolina Vital Records ..
  70. Software for Survival Analysis Using Structural Models
    David Henderson; Fiscal Year: 2007
    ..Standard statistical models for survival analysis (e.g...
  71. Pancreatic cancer survival analysis with SEER and active follow-up in SF Bay Area
    ELIZABETH HOLLY; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Pancreatic cancer survival analysis with SEER and active follow-up in SF Bay Area Each year >30,000 incident cases of pancreatic cancer (PC) are diagnosed in the U.S...
  72. ART Availability and HIV-Related Stigma/Social Consequences in Rakai, Uganda
    Sabina Haberlen; Fiscal Year: 2009
    ..Discrete-time survival analysis via pooled logistic regression will be used to examine the association between ART availability and HIV sero-..
  73. STATISTICAL MODELS OF GENETIC ANTICIPATION IN PSYCHIATRY
    Jian Huang; Fiscal Year: 2002
    ..of becoming an independent investigator specializing in the application of the statistical techniques of survival analysis to genetic modeling of the complex psychiatric disorders...
  74. Child Psychopathology, Adversity & Developing Drug Abuse
    BETH MOLNAR; Fiscal Year: 2004
    ..Multilevel statistical methods will be used including discrete time survival analysis, hierarchical linear modeling, and individual growth modeling...
  75. Prognostic Significance of Neuronal Differentiation of Cutaneous Melanoma
    Vijayasaradhi Setaluri; Fiscal Year: 2009
    ..Retrospective immuno-histochemical and survival analysis of a small cohort showed that patients whose primary tumors were MAP2-positive had significantly longer ..
  76. STATISTICAL PROBLEMS IN MULTIVARIATE SURVIVAL ANALYSIS
    Jianwen Cai; Fiscal Year: 2001
    ..Finally, the strengths and weaknesses of the proposed methodologies will be critically examined via simulations and theoretical investigations. ..
  77. ETIOLOGIES/SURVEILLANCE OF BARRETT'S ESOPHAGUS
    Douglas Corley; Fiscal Year: 2004
    ..design, case-control and cohort studies, database management, questionnaire development/implementation, survival analysis, multivariate analysis, and training in cost-effectiveness analysis. Protocols: A...