stochastic processes

Summary

Summary: Processes that incorporate some element of randomness, used particularly to refer to a time series of random variables.

Top Publications

  1. pmc Nature, nurture, or chance: stochastic gene expression and its consequences
    Arjun Raj
    Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 135:216-26. 2008
  2. pmc Stochastic mRNA synthesis in mammalian cells
    Arjun Raj
    Courant Institute of Mathematical Sciences, New York University, New York, New York, USA
    PLoS Biol 4:e309. 2006
  3. ncbi Stochastic gene expression in a single cell
    Michael B Elowitz
    Laboratory of Cancer Biology, Center for Studies in Physics and Biology, Rockefeller University, New York, NY 10021, USA
    Science 297:1183-6. 2002
  4. ncbi Phenotypic diversity, population growth, and information in fluctuating environments
    Edo Kussell
    Laboratory of Living Matter and Center for Studies in Physics and Biology, Rockefeller University, 1230 York Avenue, Box 34, New York, NY 10021 6399, USA
    Science 309:2075-8. 2005
  5. pmc Parameter estimation in biochemical pathways: a comparison of global optimization methods
    Carmen G Moles
    Process Engineering Group, Instituto de Investigaciones Marinas CSIC, 36208 Vigo, Spain
    Genome Res 13:2467-74. 2003
  6. ncbi Mammalian genes are transcribed with widely different bursting kinetics
    David M Suter
    Department of Molecular Biology, Sciences III, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneva, Switzerland
    Science 332:472-4. 2011
  7. ncbi Stochastic switching as a survival strategy in fluctuating environments
    Murat Acar
    Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Genet 40:471-5. 2008
  8. pmc Frequency-modulated nuclear localization bursts coordinate gene regulation
    Long Cai
    Howard Hughes Medical Institute, Division of Biology and Department of Applied Physics, California Institute of Technology, M C 114 96, Pasadena, California 91125, USA
    Nature 455:485-90. 2008
  9. ncbi Experimental evolution of bet hedging
    Hubertus J E Beaumont
    New Zealand Institute for Advanced Study and Allan Wilson Centre for Molecular Ecology and Evolution, Massey University, Private Bag 102904, North Shore Mail Centre, North Shore City 0745, Auckland, New Zealand
    Nature 462:90-3. 2009
  10. ncbi Spatial structure often inhibits the evolution of cooperation in the snowdrift game
    Christoph Hauert
    Department of Zoology, University of British Columbia, 6270 University Boulevard, Vancouver, British Columbia V6T 1Z4, Canada
    Nature 428:643-6. 2004

Detail Information

Publications362 found, 100 shown here

  1. pmc Nature, nurture, or chance: stochastic gene expression and its consequences
    Arjun Raj
    Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 135:216-26. 2008
    ..These situations include the stress response, metabolism, development, the cell cycle, circadian rhythms, and aging...
  2. pmc Stochastic mRNA synthesis in mammalian cells
    Arjun Raj
    Courant Institute of Mathematical Sciences, New York University, New York, New York, USA
    PLoS Biol 4:e309. 2006
    ..These results demonstrate that gene expression in mammalian cells is subject to large, intrinsically random fluctuations and raise questions about how cells are able to function in the face of such noise...
  3. ncbi Stochastic gene expression in a single cell
    Michael B Elowitz
    Laboratory of Cancer Biology, Center for Studies in Physics and Biology, Rockefeller University, New York, NY 10021, USA
    Science 297:1183-6. 2002
    ..These results establish a quantitative foundation for modeling noise in genetic networks and reveal how low intracellular copy numbers of molecules can fundamentally limit the precision of gene regulation...
  4. ncbi Phenotypic diversity, population growth, and information in fluctuating environments
    Edo Kussell
    Laboratory of Living Matter and Center for Studies in Physics and Biology, Rockefeller University, 1230 York Avenue, Box 34, New York, NY 10021 6399, USA
    Science 309:2075-8. 2005
    ..The optimal switching rates then mimic the statistics of environmental changes. We derive a relation between the long-term growth rate of the organism and the information available about its fluctuating environment...
  5. pmc Parameter estimation in biochemical pathways: a comparison of global optimization methods
    Carmen G Moles
    Process Engineering Group, Instituto de Investigaciones Marinas CSIC, 36208 Vigo, Spain
    Genome Res 13:2467-74. 2003
    ..Although these stochastic methods cannot guarantee global optimality with certainty, their robustness, plus the fact that in inverse problems they have a known lower bound for the cost function, make them the best available candidates...
  6. ncbi Mammalian genes are transcribed with widely different bursting kinetics
    David M Suter
    Department of Molecular Biology, Sciences III, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneva, Switzerland
    Science 332:472-4. 2011
    ..Our analysis demonstrated that bursting kinetics are highly gene-specific, reflecting refractory periods during which genes stay inactive for a certain time before switching on again...
  7. ncbi Stochastic switching as a survival strategy in fluctuating environments
    Murat Acar
    Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Genet 40:471-5. 2008
    ..These results suggest that cells may tune inter-phenotype switching rates to the frequency of environmental changes...
  8. pmc Frequency-modulated nuclear localization bursts coordinate gene regulation
    Long Cai
    Howard Hughes Medical Institute, Division of Biology and Department of Applied Physics, California Institute of Technology, M C 114 96, Pasadena, California 91125, USA
    Nature 455:485-90. 2008
    ....
  9. ncbi Experimental evolution of bet hedging
    Hubertus J E Beaumont
    New Zealand Institute for Advanced Study and Allan Wilson Centre for Molecular Ecology and Evolution, Massey University, Private Bag 102904, North Shore Mail Centre, North Shore City 0745, Auckland, New Zealand
    Nature 462:90-3. 2009
    ..These findings capture the adaptive evolution of bet hedging in the simplest of organisms, and suggest that risk-spreading strategies may have been among the earliest evolutionary solutions to life in fluctuating environments...
  10. ncbi Spatial structure often inhibits the evolution of cooperation in the snowdrift game
    Christoph Hauert
    Department of Zoology, University of British Columbia, 6270 University Boulevard, Vancouver, British Columbia V6T 1Z4, Canada
    Nature 428:643-6. 2004
    ..In particular, spatial structure eliminates cooperation if the cost-to-benefit ratio of cooperation is high. Our results caution against the common belief that spatial structure is necessarily beneficial for cooperative behaviour...
  11. pmc Replication timing and its emergence from stochastic processes
    John Bechhoefer
    Department of Physics, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada
    Trends Genet 28:374-81. 2012
    ..This work suggests that replication timing need not be controlled by a hierarchical mechanism that imposes replication timing from a central regulator, but instead results from simple rules that affect individual origins...
  12. ncbi Enhancement of cellular memory by reducing stochastic transitions
    Murat Acar
    Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 435:228-32. 2005
    ..Indeed, the rate at which single cells randomly switch back and forth between expression states was reduced. These observations provide a quantitative understanding of the stability and reversibility of cellular differentiation states...
  13. ncbi Stochasticity in gene expression: from theories to phenotypes
    Mads Kaern
    Department of Cellular and Molecular Medicine and Ottawa Institute of Systems Biology, University of Ottawa, 451 Smyth Road, Ottawa, Ontario K1H8M5, Canada
    Nat Rev Genet 6:451-64. 2005
    ..It can provide the flexibility needed by cells to adapt to fluctuating environments or respond to sudden stresses, and a mechanism by which population heterogeneity can be established during cellular differentiation and development...
  14. ncbi Elite and stochastic models for induced pluripotent stem cell generation
    Shinya Yamanaka
    Center for iPS Cell Research and Application CiRA, Kyoto University, Kyoto 606 8507, Japan
    Nature 460:49-52. 2009
    ..Here I consider reasons for bottlenecks in induced pluripotent stem cell generation, and propose a model in which most or all cells have the potential to become pluripotent...
  15. ncbi Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise
    John R S Newman
    Howard Hughes Medical Institute, San Francisco, California, USA
    Nature 441:840-6. 2006
    ..Thus, these studies reveal a remarkable structure to biological noise and suggest that protein noise levels have been selected to reflect the costs and potential benefits of this variation...
  16. ncbi A synthetic oscillatory network of transcriptional regulators
    M B Elowitz
    Department of Molecular Biology and Physics, Princeton University, New Jersey 08544, USA
    Nature 403:335-8. 2000
    ..Such 'rational network design may lead both to the engineering of new cellular behaviours and to an improved understanding of naturally occurring networks...
  17. ncbi Transcriptome-wide noise controls lineage choice in mammalian progenitor cells
    Hannah H Chang
    Vascular Biology Programme, Department of Pathology and Surgery, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 453:544-7. 2008
    ....
  18. pmc Non-genetic heterogeneity from stochastic partitioning at cell division
    Dann Huh
    Department of Systems Biology, Harvard University, Boston, Massachusetts, USA
    Nat Genet 43:95-100. 2011
    ..We propose experiments to separate between these two types of fluctuations and discuss future directions...
  19. pmc Noise in gene expression: origins, consequences, and control
    Jonathan M Raser
    Medical Scientist Training Program, University of California San Francisco, 600 16th Street, GH S472D, San Francisco, CA 94143 2240, USA
    Science 309:2010-3. 2005
    ..In this review, we summarize noise terminology and comment on recent investigations into the sources, consequences, and control of noise in gene expression...
  20. pmc Fluctuating synaptic conductances recreate in vivo-like activity in neocortical neurons
    A Destexhe
    Unite de Neurosciences Integratives et Computationnelles, CNRS, UPR 2191, Gif sur Yvette, France
    Neuroscience 107:13-24. 2001
    ..We conclude that many of the characteristics of cortical neurons in vivo can be explained by fast glutamatergic and GABAergic conductances varying stochastically...
  21. ncbi Dynamics of the 2001 UK foot and mouth epidemic: stochastic dispersal in a heterogeneous landscape
    M J Keeling
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    Science 294:813-7. 2001
    ..We assess the history and possible duration of the epidemic, the performance of control strategies, and general implications for disease dynamics in space and time...
  22. pmc Transmission dynamics and control of severe acute respiratory syndrome
    Marc Lipsitch
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Science 300:1966-70. 2003
    ..Public-health efforts to reduce transmission are expected to have a substantial impact on reducing the size of the epidemic...
  23. ncbi Regulation of noise in the expression of a single gene
    Ertugrul M Ozbudak
    Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Genet 31:69-73. 2002
    ..Our results thus provide the first direct experimental evidence of the biochemical origin of phenotypic noise, demonstrating that the level of phenotypic variation in an isogenic population can be regulated by genetic parameters...
  24. ncbi Stochastic resonance and sensory information processing: a tutorial and review of application
    Frank Moss
    Center for Neurodynamics, University of Missouri at St Louis, St Louis, MO, USA
    Clin Neurophysiol 115:267-81. 2004
    ..To review the stochastic resonance phenomena observed in sensory systems and to describe how a random process ('noise') added to a subthreshold stimulus can enhance sensory information processing and perception...
  25. ncbi Synchrony, waves, and spatial hierarchies in the spread of influenza
    Cecile Viboud
    Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA
    Science 312:447-51. 2006
    ..A simple epidemiological model, based on the gravity formulation, captures the observed increase of influenza spatial synchrony with transmissibility; high transmission allows influenza to spread rapidly beyond local spatial constraints...
  26. pmc Stochastic gene expression in fluctuating environments
    Mukund Thattai
    Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genetics 167:523-30. 2004
    ..However, this heterogeneity is beneficial only if the bacterial response rate is sufficiently low. Our results could be useful in the design of artificial evolution experiments and in the optimization of fermentation processes...
  27. pmc Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence
    Joao F Passos
    Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom
    PLoS Biol 5:e110. 2007
    ..X foci. We propose that mitochondrial ROS is a major determinant of telomere-dependent senescence at the single-cell level that is responsible for cell-to-cell variation in replicative lifespan...
  28. pmc Control of stochasticity in eukaryotic gene expression
    Jonathan M Raser
    Department of Biochemistry and Biophysics, Howard Hughes Medical Institute, University of California San Francisco UCSF, 600 16th Street, Room S472D, San Francisco, CA 94143 2240, USA
    Science 304:1811-4. 2004
    ..These mutations suggest that noise is an evolvable trait that can be optimized to balance fidelity and diversity in eukaryotic gene expression...
  29. ncbi Network theory and SARS: predicting outbreak diversity
    Lauren Ancel Meyers
    Section of Integrative Biology and Institute for Cellular and Molecular Biology, University of Texas at Austin, 1 University Station C0930, Austin, TX 78712, USA
    J Theor Biol 232:71-81. 2005
    ..We offer quantitative insight into the heterogeneity of SARS outbreaks worldwide, and illustrate the utility of this approach for assessing public health strategies...
  30. ncbi Recovery rates reflect distance to a tipping point in a living system
    Annelies J Veraart
    Department of Aquatic Ecology and Water Quality Management, Wageningen University, PO Box 47, NL 6700 AA, Wageningen, The Netherlands
    Nature 481:357-9. 2012
    ..Although stochasticity prohibits prediction of the timing of critical transitions, our results suggest that indicators of slowing down may be used to rank complex systems on a broad scale from resilient to fragile...
  31. pmc Dynamic analysis of stochastic transcription cycles
    Claire V Harper
    Centre for Cell Imaging, School of Biological Sciences, University of Liverpool, Liverpool, United Kingdom
    PLoS Biol 9:e1000607. 2011
    ..Stochastically timed bursts of transcription in an apparently random subset of cells in a tissue may thus produce an overall coordinated but heterogeneous phenotype capable of acute responses to stimuli...
  32. pmc Analytical distributions for stochastic gene expression
    Vahid Shahrezaei
    Centre for Non linear Dynamics, Department of Physiology, McGill University, 3655 Promenade Sir William Osler, Montreal, QC, Canada, H3G 1Y6
    Proc Natl Acad Sci U S A 105:17256-61. 2008
    ..More generally, we introduce a technique to derive a simpler, effective dynamics for a stochastic system by eliminating a fast variable...
  33. pmc Nanog variability and pluripotency regulation of embryonic stem cells--insights from a mathematical model analysis
    Ingmar Glauche
    Institute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, University of Leipzig, Leipzig, Germany
    PLoS ONE 5:e11238. 2010
    ..Furthermore, we provide a conceptual framework that consistently explains Nanog variability and a potential "gate-keeper" function of Nanog expression with respect to the control of ES cell differentiation...
  34. ncbi The dynamics of measles in sub-Saharan Africa
    Matthew J Ferrari
    Center for Infectious Disease Dynamics, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Nature 451:679-84. 2008
    ..Such erratic dynamics emphasize the importance both of control strategies that address build-up of susceptible individuals and efforts to mitigate the impact of large outbreaks when they occur...
  35. ncbi A chance at survival: gene expression noise and phenotypic diversification strategies
    Dawn Fraser
    Ottawa Institute of Systems Biology, Ottawa, Canada
    Mol Microbiol 71:1333-40. 2009
    ..Here, we discuss different scenarios where gene expression noise might bestow a selective advantage under stress, highlighting a potentially fundamental role of stochastic mechanisms in the evolution of microbial survival strategies...
  36. ncbi Noise can induce bimodality in positive transcriptional feedback loops without bistability
    Tsz Leung To
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 327:1142-5. 2010
    ....
  37. pmc Noise propagation and signaling sensitivity in biological networks: a role for positive feedback
    Gil Hornung
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    PLoS Comput Biol 4:e8. 2008
    ..As the design of biological networks optimizes for multiple constraints, positive feedback can be used to improve sensitivity without a compromise in the ability to buffer propagated noise...
  38. ncbi Effects of molecular memory and bursting on fluctuations in gene expression
    Juan M Pedraza
    Department of Systems Biology, Harvard University, Boston, MA 02115, USA
    Science 319:339-43. 2008
    ..Characterizing the random events that give rise to noise in concentrations instead requires dynamic measurements with single-molecule resolution...
  39. ncbi Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells
    Piyush B Gupta
    Broad Institute, Cambridge, MA 02142, USA
    Cell 146:633-44. 2011
    ..These findings contribute to our understanding of cancer heterogeneity and reveal how stochasticity in single-cell behaviors promotes phenotypic equilibrium in populations of cancer cells...
  40. ncbi Stochastic modelling for quantitative description of heterogeneous biological systems
    Darren J Wilkinson
    School of Mathematics and Statistics and the Centre for Integrated Systems Biology of Ageing and Nutrition, Newcastle University, Newcastle upon Tyne, Tyne and Wear NE1 7RU, UK
    Nat Rev Genet 10:122-33. 2009
    ..Both frameworks are needed to adequately describe observed noise, variability and heterogeneity of biological systems over a range of scales of biological organization...
  41. ncbi Efficient step size selection for the tau-leaping simulation method
    Yang Cao
    Department of Computer Science, Virginia Tech, Blacksburg, Virginia 24061, USA
    J Chem Phys 124:044109. 2006
    ..This new tau-selection procedure is more accurate, easier to code, and faster to execute than the currently used procedure. The speedup in execution will be especially pronounced in systems that have many reaction channels...
  42. pmc Cell-to-cell stochastic variation in gene expression is a complex genetic trait
    Juliet Ansel
    Universite de Lyon, Lyon, France
    PLoS Genet 4:e1000049. 2008
    ..The complex genetic architecture of noise buffering couples genetic to non-genetic robustness and provides a molecular basis to the probabilistic nature of complex traits...
  43. ncbi Continuous and discrete mathematical models of tumor-induced angiogenesis
    A R Anderson
    Department of Mathematics, University of Dundee, U K
    Bull Math Biol 60:857-99. 1998
    ..The theoretical capillary networks generated by computer simulations of the discrete model are compared with the morphology of capillary networks observed in in vivo experiments...
  44. ncbi The benefits of noise in neural systems: bridging theory and experiment
    Mark D McDonnell
    The Computational and Theoretical Neuroscience Laboratory, Institute for Telecommunications Research, University of South Australia, Mawson Lakes, SA 5095, Australia
    Nat Rev Neurosci 12:415-26. 2011
    ..Understanding the diverse roles of noise in neural computation will require the design of experiments based on new theory and models, into which biologically appropriate experimental detail feeds back at various levels of abstraction...
  45. pmc What is stochastic resonance? Definitions, misconceptions, debates, and its relevance to biology
    Mark D McDonnell
    Institute for Telecommunications Research, University of South Australia, Mawson Lakes, South Australia, Australia
    PLoS Comput Biol 5:e1000348. 2009
    ....
  46. ncbi Real-time kinetics of gene activity in individual bacteria
    Ido Golding
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Cell 123:1025-36. 2005
    ..This greatly facilitates kinetic interpretations in terms of the integer-valued random processes that produce the fluctuations...
  47. ncbi Containing pandemic influenza at the source
    Ira M Longini
    Department of Biostatistics, The Rollins School of Public Health, Emory University, 1518 Clifton Road, N E, Atlanta, GA 30322, USA
    Science 309:1083-7. 2005
    ..1. Combinations of targeted antiviral prophylaxis, pre-vaccination, and quarantine could contain strains with an R(0) as high as 2.4...
  48. pmc Niche tradeoffs, neutrality, and community structure: a stochastic theory of resource competition, invasion, and community assembly
    David Tilman
    Department of Ecology, Evolution, and Behavior, University of Minnesota, 1987 Upper Buford Circle, St Paul, MN 55108, USA
    Proc Natl Acad Sci U S A 101:10854-61. 2004
    ..This prediction provides a potential solution to the invasion paradox, which is the tendency for highly diverse regions to be more heavily invaded...
  49. ncbi Evolutionary dynamics on graphs
    Erez Lieberman
    Program for Evolutionary Dynamics, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 433:312-6. 2005
    ..Evolutionary graph theory has many fascinating applications ranging from ecology to multi-cellular organization and economics...
  50. ncbi Different epidemic curves for severe acute respiratory syndrome reveal similar impacts of control measures
    Jacco Wallinga
    National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Am J Epidemiol 160:509-16. 2004
    ..In controlling SARS outbreaks, timely alerts have been essential: Delaying the institution of control measures by 1 week would have nearly tripled the epidemic size and would have increased the expected epidemic duration by 4 weeks...
  51. pmc Methicillin-resistant Staphylococcus aureus in hospitals and the community: stealth dynamics and control catastrophes
    B S Cooper
    Department of Medical Microbiology, Royal Free and University College Medical School, University of London, WC1E 7HU, United Kingdom
    Proc Natl Acad Sci U S A 101:10223-8. 2004
    ..If resources do not scale with MRSA prevalence, isolation policies can fail "catastrophically."..
  52. pmc Sensitivity, robustness, and identifiability in stochastic chemical kinetics models
    Michał Komorowski
    Division of Molecular Biosciences, Imperial College London, London SW7 2AZ, United Kingdom
    Proc Natl Acad Sci U S A 108:8645-50. 2011
    ..correlations and show how this approach can be used in the analysis and design of experiments probing stochastic processes at the cellular level...
  53. ncbi The finite state projection algorithm for the solution of the chemical master equation
    Brian Munsky
    Mechanical and Environmental Engineering, University of California Santa Barbara, Santa Barbara, California 93106, USA
    J Chem Phys 124:044104. 2006
    ..Furthermore, due to very small molecular counts in these particular examples, the FSP also performs far more effectively than tau leaping methods...
  54. ncbi Stochastic simulation of chemical kinetics
    Daniel T Gillespie
    Dan T Gillespie Consulting, Castaic, CA 91384, USA
    Annu Rev Phys Chem 58:35-55. 2007
    ....
  55. ncbi Noise in eukaryotic gene expression
    William J Blake
    Center for BioDynamics, Center for Advanced Biotechnology, Bioinformatics Program, and Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, Massachusetts 02215, USA
    Nature 422:633-7. 2003
    ..This result has implications for the role of noise in phenotypic variation and cellular differentiation...
  56. pmc A model of yeast cell-cycle regulation based on multisite phosphorylation
    Debashis Barik
    Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Mol Syst Biol 6:405. 2010
    ..The model gives a quantitatively accurate account of the variability observed in the G1-S transition in budding yeast, which is governed by an underlying sizer+timer control system...
  57. ncbi Stochastic resonance in binocular rivalry
    Yee Joon Kim
    Department of Psychology, Institute for Neuroscience, Northwestern University, Evanston, IL 60208, USA
    Vision Res 46:392-406. 2006
    ....
  58. pmc Systems biology of stem cell fate and cellular reprogramming
    Ben D MacArthur
    Department of Gene and Cell Medicine and Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Rev Mol Cell Biol 10:672-81. 2009
    ....
  59. pmc Strategies for pandemic and seasonal influenza vaccination of schoolchildren in the United States
    Nicole E Basta
    Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA
    Am J Epidemiol 170:679-86. 2009
    ..Given the current worldwide threat of novel influenza A (H1N1), with an estimated R of 1.4-1.6, health officials should consider strategies for vaccinating children against novel influenza A (H1N1) as well as seasonal influenza...
  60. ncbi RNA secondary structure prediction using stochastic context-free grammars and evolutionary history
    B Knudsen
    Department of Genetics and Ecology, The Institute of Biological Sciences, University of Aarhus, Building 550, Ny Munkegade, 8000 Aarhus C, Denmark
    Bioinformatics 15:446-54. 1999
    ..The method reported here is based on stochastic context-free grammars (SCFGs) to give a prior probability distribution of structures...
  61. pmc Population robustness arising from cellular heterogeneity
    Pawel Paszek
    Centre for Cell Imaging, School of Biological Sciences, University of Liverpool, Liverpool L69 7ZB, United Kingdom
    Proc Natl Acad Sci U S A 107:11644-9. 2010
    ..Our analyses suggest in contrast, that this cellular variation might be advantageous and subject to evolutionary selection. Alternative types of therapy could perhaps be designed to modulate this cellular heterogeneity...
  62. pmc A stochastic single-molecule event triggers phenotype switching of a bacterial cell
    Paul J Choi
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Science 322:442-6. 2008
    ..Hence, a stochastic single-molecule event determines a cell's phenotype...
  63. ncbi Beyond the sequence: cellular organization of genome function
    Tom Misteli
    National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 128:787-800. 2007
    ..Recent insights into the cell biology of genomes have overturned long-held dogmas and have led to new models for many essential cellular processes, including gene expression and genome stability...
  64. ncbi Demography in an increasingly variable world
    Mark S Boyce
    Department of Biological Sciences, University of Alberta, Edmonton, AB, Canada, T6G 2E9
    Trends Ecol Evol 21:141-8. 2006
    ..We also highlight new tools for anticipating the consequences of the magnitude and temporal patterning of environmental variability...
  65. pmc Stochasticity and cell fate
    Richard Losick
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Science 320:65-8. 2008
    ..Stochasticity has important mechanistic requirements. We speculate on why stochasticity is advantageous-and even critical in some circumstances-to the individual, the colony, or the species...
  66. pmc Positive feedback and noise activate the stringent response regulator rel in mycobacteria
    Kamakshi Sureka
    Department of Chemistry, Bose Institute, Kolkata, India
    PLoS ONE 3:e1771. 2008
    ....
  67. pmc Predicting the spatial dynamics of rabies epidemics on heterogeneous landscapes
    David L Smith
    Department of Epidemiology and Preventive Medicine, University of Maryland, 115 Howard Hall, 660 West Redwood Street, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 99:3668-72. 2002
    ....
  68. pmc Inference for nonlinear dynamical systems
    E L Ionides
    Department of Statistics, University of Michigan, 1085 South University Avenue, Ann Arbor, MI 48109 1107, USA
    Proc Natl Acad Sci U S A 103:18438-43. 2006
    ..We construct confidence intervals, perform residual analysis, and apply other diagnostics. Our analysis, based upon a model capturing the intrinsic nonlinear dynamics of the system, reveals some effects overlooked by previous studies...
  69. pmc Neural dynamics as sampling: a model for stochastic computation in recurrent networks of spiking neurons
    Lars Buesing
    Institute for Theoretical Computer Science, Graz University of Technology, Graz, Austria
    PLoS Comput Biol 7:e1002211. 2011
    ..This provides a step towards closing the gap between abstract functional models of cortical computation and more detailed models of networks of spiking neurons...
  70. ncbi Stochastic reaction-diffusion simulation with MesoRD
    Johan Hattne
    Department of Cell and Molecular Biology, BMC, Uppsala University, 75124 Uppsala, Sweden
    Bioinformatics 21:2923-4. 2005
    ..In particular, it is an implementation of the next subvolume method, which is an exact method to simulate the Markov process corresponding to the reaction-diffusion master equation...
  71. pmc Comparison of deterministic and stochastic models of the lac operon genetic network
    Michail Stamatakis
    Department of Chemical and Biomolecular Engineering, Rice University, Houston, Texas 77005, USA
    Biophys J 96:887-906. 2009
    ..For these cases, the temporal asymptotic behavior of the deterministic model remains unchanged, indicating a role of stochasticity in modulating the behavior of the system...
  72. pmc Bacterial persistence: a model of survival in changing environments
    Edo Kussell
    Rockefeller University, New York, New York 10021 6399, USA
    Genetics 169:1807-14. 2005
    ..In contrast to typical examples of adaptations to features of a single environment, persistence appears to constitute an adaptation that is tuned to the distribution of environmental change...
  73. pmc Stochastic models for regulatory networks of the genetic toggle switch
    Tianhai Tian
    Advanced Computational Modelling Centre, University of Queensland, Brisbane, QLD 4072, Australia
    Proc Natl Acad Sci U S A 103:8372-7. 2006
    ....
  74. pmc Drought mediates the importance of stochastic community assembly
    Jonathan M Chase
    Deptartment of Biology, Washington University, Box 1229, St Louis, MO 63130, USA
    Proc Natl Acad Sci U S A 104:17430-4. 2007
    ..These results implicate the critical role for understanding the processes of community assembly when examining patterns of biodiversity at different spatial scales...
  75. pmc Pulsatile stimulation determines timing and specificity of NF-kappaB-dependent transcription
    Louise Ashall
    Centre for Cell Imaging, School of Biological Sciences, Bioscience Research Building, Crown Street, Liverpool, L69 7ZB, UK
    Science 324:242-6. 2009
    ..Altering the stimulation intervals gave different patterns of NF-kappaB-dependent gene expression, which supports the idea that oscillation frequency has a functional role...
  76. pmc Modeling the worldwide spread of pandemic influenza: baseline case and containment interventions
    Vittoria Colizza
    School of Informatics and Center for Biocomplexity, Indiana University, Bloomington, Indiana, United States of America
    PLoS Med 4:e13. 2007
    ..Here we study the worldwide spread of a pandemic and its possible containment at a global level taking into account all available information on air travel...
  77. ncbi Predator-prey cycles from resonant amplification of demographic stochasticity
    A J McKane
    Theory Group, School of Physics and Astronomy, University of Manchester, Manchester M13 9PL, United Kingdom
    Phys Rev Lett 94:218102. 2005
    ..Our results indicate that additional biological mechanisms, such as predator satiation, may not be necessary to explain observed predator-prey cycles in real (finite) populations...
  78. pmc Fast evaluation of fluctuations in biochemical networks with the linear noise approximation
    Johan Elf
    Department of Cell and Molecular Biology, Uppsala University, BMC, 751 24 Uppsala, Sweden
    Genome Res 13:2475-84. 2003
    ..We describe how the LNA can give precise system descriptions also near macroscopic instabilities by suitable variable changes and elimination of fast variables...
  79. pmc Stochastic simulations on the reliability of action potential propagation in thin axons
    A Aldo Faisal
    Department of Zoology, Cambridge University, Cambridge, United Kingdom
    PLoS Comput Biol 3:e79. 2007
    ..In contrast we find that thicker axons above 0.5 microm diameter are reliable...
  80. ncbi Noisy clockwork: time series analysis of population fluctuations in animals
    O N Bjørnstad
    Department of Entomology, 501 ASI Building, Penn State University, University Park, PA 16802, USA
    Science 293:638-43. 2001
    ..We discuss recent advances in understanding ecological dynamics and testing theory using long-term data and review how dynamical forces interact to generate some central field and laboratory time series...
  81. ncbi Stochastic mapping of morphological characters
    John P Huelsenbeck
    Section of Ecology, Behavior and Evolution, Division of Biology, University of California San Diego, La Jolla, California 92093 0116, USA
    Syst Biol 52:131-58. 2003
    ..Biol. 51:729-739) to the mapping of morphological characters under continuous-time Markov models and demonstrate here the utility of the method for mapping characters on trees and for identifying character correlation...
  82. pmc Timing cellular decision making under noise via cell-cell communication
    Aneta Koseska
    Center for Dynamics of Complex Systems, University of Potsdam, Potsdam, Germany
    PLoS ONE 4:e4872. 2009
    ..In other words, the summation performed by the cell population would average out the noise and reduce its detrimental impact...
  83. pmc Noise in gene expression determines cell fate in Bacillus subtilis
    Hédia Maamar
    Public Health Research Institute Center, New Jersey Medical School, 225 Warren Street, Newark, NJ 07103, USA
    Science 317:526-9. 2007
    ..These results illustrate how such stochastic transitions are regulated in a natural system and suggest that noise characteristics are subject to evolutionary forces...
  84. pmc Stochastic spineless expression creates the retinal mosaic for colour vision
    Mathias F Wernet
    Center for Developmental Genetics, Department of Biology, New York University, 100 Washington Place, New York, New York 10003, USA
    Nature 440:174-80. 2006
    ..Therefore, this study suggests that the entire retinal mosaic required for colour vision is defined by the stochastic expression of a single transcription factor, Spineless...
  85. ncbi Controlling nosocomial infection based on structure of hospital social networks
    Taro Ueno
    Tokyo Metropolitan Hiroo General Hospital, 2 34 10 Ebisu, Shibuya, Tokyo 150 0013, Japan
    J Theor Biol 254:655-66. 2008
    ....
  86. pmc Stochastic receptor expression determines cell fate upon interferon treatment
    Doron Levin
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    Mol Cell Biol 31:3252-66. 2011
    ..Conversely, a high number of receptors is required for antiproliferative activity, which allows for fine-tuning on a single-cell level...
  87. pmc Stochastic and deterministic processes interact in the assembly of desert microbial communities on a global scale
    Tancredi Caruso
    Institut fur Biologie, Plant Ecology, Freie Universitat Berlin, Berlin, Germany
    ISME J 5:1406-13. 2011
    ..Null models applied to the photosynthetic assemblage revealed that stochastic processes exerted most effect on the assemblage, although the level of community dissimilarity varied between ..
  88. ncbi Molecular orientation affects localization accuracy in superresolution far-field fluorescence microscopy
    Johann Engelhardt
    German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Nano Lett 11:209-13. 2011
    ..When imaging rotation-impaired fluorophores of unknown random orientation, the average localization accuracy in three-dimensional samples is typically limited to about ±32 nm, restricting the attainable resolution accordingly...
  89. ncbi Multispike interactions in a stochastic model of spike-timing-dependent plasticity
    Peter A Appleby
    Institute for Theoretical Biology, Humboldt Universitat zu Berlin, Invalidenstrasse 43, D 10115 Berlin, Germany
    Neural Comput 19:1362-99. 2007
    ....
  90. ncbi Probing gene expression in live cells, one protein molecule at a time
    Ji Yu
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Science 311:1600-3. 2006
    ..The quantitative study of low-level gene expression demonstrates the potential of single-molecule experiments in elucidating the workings of fundamental biological processes in living cells...
  91. ncbi Longevity can buffer plant and animal populations against changing climatic variability
    William F Morris
    Biology Department, Duke University, Box 90338, Durham, North Carolina 27708 0338, USA
    Ecology 89:19-25. 2008
    ....
  92. pmc Robust transport by multiple motors with nonlinear force-velocity relations and stochastic load sharing
    Ambarish Kunwar
    Department of Neurobiology, Physiology and Behavior, University of California Davis, Davis, CA 95616, USA
    Phys Biol 7:16012. 2010
    ..Finally, our simulations predict that the stochastic effects are responsible for a significant dispersion of velocities generated by the 'tug-of-war' of the multiple opposing motors...
  93. ncbi Stochastic protein expression in individual cells at the single molecule level
    Long Cai
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    Nature 440:358-62. 2006
    ..This microfluidic single cell assay opens up possibilities for system-wide characterization of the expression of these low copy number proteins...
  94. ncbi Evaluation of stochastic differential equation approximation of ion channel gating models
    Ian C Bruce
    Department of Electrical and Computer Engineering, Room ITB A213, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada
    Ann Biomed Eng 37:824-38. 2009
    ....
  95. pmc Bilinear dynamical systems
    W Penny
    Wellcome Department of Imaging Neuroscience, University College, London WC1N 3BG, UK
    Philos Trans R Soc Lond B Biol Sci 360:983-93. 2005
    ..We report preliminary results that focus on the assumed stochastic nature of the neurodynamic model and compare the method to Wiener deconvolution...
  96. ncbi A delay stochastic process with applications in molecular biology
    Robert Schlicht
    Institute of Biomathematics and Biometry, Ingolstädter Landstr Neuherberg, Germany
    J Math Biol 57:613-48. 2008
    ..Simulation of the molecular oscillator controlling this process reveals major differences between stochastic and deterministic models...
  97. pmc Stochastic signal processing and transduction in chemotactic response of eukaryotic cells
    Masahiro Ueda
    Laboratories for Nanobiology, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan
    Biophys J 93:11-20. 2007
    ..Theoretical consideration of noisy signal transduction by chemotactic signaling systems can further be applied to signaling systems in general...
  98. pmc Exact results for the evolution of stochastic switching in variable asymmetric environments
    Bernadett Gaál
    Systems Biology Doctoral Training Centre, University of Oxford, Oxford, United Kingdom
    Genetics 184:1113-9. 2010
    ..The evolutionary implications of our findings are discussed in relation to their to real-world applications in the light of recent experimental evidence...
  99. ncbi A generalized Luria-Delbrück model
    A Dewanji
    Indian Statistical Institute, Applied Statistics Division, 203, B T Road, Kolkata 700 108, India
    Math Biosci 197:140-52. 2005
    ..We also discuss connections with previous work on carcinogenesis models...
  100. ncbi Stochastic epidemic models: a survey
    Tom Britton
    Department of Mathematics, Stockholm University, SE 10691 Stockholm, Sweden
    Math Biosci 225:24-35. 2010
    ..Several generalizations towards realism, e.g. multitype and household epidemic models, are also presented, as is a model for endemic diseases...
  101. ncbi Noise-induced breakdown of the Michaelis-Menten equation in steady-state conditions
    R Grima
    School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    Phys Rev Lett 102:218103. 2009
    ....

Research Grants63

  1. Dietary Risk for Colon Cancer in the Mouse
    Leonard H Augenlicht; Fiscal Year: 2013
    ..abstract_text> ..
  2. Novel whole cell HTS for inhibitors of bacterial toxin-antitoxin interaction
    JAMES SCOTT BUTLER; Fiscal Year: 2013
    ..Moreover, it appears that stochastic processes elicit the formation of small numbers of persister cells within growing populations of bacteria...
  3. Modeling B Cell Vaccine Responses in Transplant Recipients
    Martin S Zand; Fiscal Year: 2013
    ..If successful, it would greatly advance prediction of vaccine responses and vaccine strategies that improve influenza immunity in kidney transplant recipients ..
  4. Estimating the Demand for Medicaid Financial Long-Term Care for the Elderly
    Arpita Chattopadhyay; Fiscal Year: 2013
    ..Robert Newcomer and Charlene Harrington, experts in long-term care issues;Dr. Peter Bacchetti, expert in stochastic processes in chronic disease modeling;and Dr...
  5. Microbial Ecology of the Zebrafish Intestine
    John F Rawls; Fiscal Year: 2013
    ..microbial communities include the extent to which these communities are assembled by host selection or by stochastic processes. If host selection is important, what mechanisms by which this selection occurs? Do selective forces change ..
  6. Microsystems for targeting Levy walks in metastatic cancer cells
    BARTOSZ ANDRZEJ GRZYBOWSKI; Fiscal Year: 2013
    ..The importance of this finding is that it is known from the theory of stochastic processes that L[unreadable]vy walks represent an optimal search strategy - one that is often employed by animal ..
  7. Intercellular Interactions Modulate Carcinogenesis Course: A Dynamic System Study
    Lynn Hlatky; Fiscal Year: 2013
    ..abstract_text> ..
  8. Statistical methods for understanding heterogeneity in cocaine relapse
    Yongtao Guan; Fiscal Year: 2013
    ..They can also help assess the efficacy of treatment approaches by providing a more fine-tuned analysis to cocaine relapse trajectories. ..
  9. Functional and Molecular Analysis of Scout Cell Awakening
    SLAVA SIMON EPSTEIN; Fiscal Year: 2013
    ..This may ultimately lead to better tools for disease control, and is especially relevant to latent infections. ..
  10. Genetic control of colorectal cancer histopathology
    David W Threadgill; Fiscal Year: 2013
    ..The identification of genetic polymorphisms predisposing patient to flat adenomas will be useful as prognostic markers for individuals needing extra scrutiny during colonoscopy. ..
  11. Synthetic Lethal Modifier of a New Ciliopathy Gene
    Bruce A Hamilton; Fiscal Year: 2013
    ..The distribution of phenotypes in surviving animals is dependent on both modifier genes and apparently stochastic processes. However, on the most commonly used strain background, no mutant animals survive...
  12. Semiparametric Bayesian Survival Analysis
    Debajyoti Sinha; Fiscal Year: 2010
    ..New and existing methods will be evaluated and compared using analysis of mainly cancer studies data from the published literature and from other sources such as the MUSC Hoolings Cancer Center. ..
  13. Hierarchical spatial process models for estimating and predicting health effects
    Sudipto Banerjee; Fiscal Year: 2010
    ....
  14. MECHANISMS AND CONSEQUENCES OF DELETERIOUS EVOLUTION IN BACTERIA
    Jennifer J Wernegreen; Fiscal Year: 2010
    ..By deciphering fundamental mechanisms that influence bacterial genome evolution, this study will contribute to a predictive framework for understanding how microbes evolve. ..
  15. Large Scale Nanochannel Electroporation (NEP) for Cell Reprogramming
    José Javier Otero; Fiscal Year: 2013
    ..the great majority of these techniques, with the exception of microinjection, are based on stochastic processes that lead to random cell transfection with significant cell-to-cell variations...
  16. Causal Effects of Time-Dependent Treatment: Optimizing Care of Cancer Patients
    Igor Akushevich; Fiscal Year: 2013
    ..Successful completion of this project will assist clinicians in choosing the optimal lung cancer treatment that balances benefits and risks based on individual patient characteristics. ..
  17. Normal and Pathological Function of the Dentate Gyrus
    Douglas A Coulter; Fiscal Year: 2013
    ....
  18. Stochastic dynamics for multiscale biology
    Eric D Mjolsness; Fiscal Year: 2011
    ..and stochastic mathematics, including advances arising from operator algebra, quantum field theory, stochastic processes, statistical physics, machine learning, and related mathematically grounded fields...
  19. Genetic regulation
    José Miguel Ponciano; Fiscal Year: 2013
    ..In addition, a theoretical and practical knowledge gap will be filled so that the risk to diseases associated with responses to disturbances of human-associated microbial ecosystems can be better defined. ..
  20. HIV Risk Dynamics, Genetic Patterns, and Control
    JAMES STEPHEN KOOPMAN; Fiscal Year: 2012
    ..The new insights and analysis methods developed should help all control programs everywhere set more effective control priorities. ..
  21. Biostatistics Training for Research in the Biosciences
    John D Kalbfleisch; Fiscal Year: 2010
    ..A new Ph.D. course will be developed in stochastic processes including applications in the biosciences...
  22. DETERMINANTS OF DISABILITY IN ELDERLY MEN
    MIRJA NISSINEN; Fiscal Year: 1993
    ..Together with the long follow-up with standardized methodology, this is one of the unique streghts of the proposed study...
  23. WEALTH, SAVINGS & FINANCIAL SECURITY IN OLDER HOUSEHOLDS
    Matthew Shapiro; Fiscal Year: 2000
    ....
  24. Neural limits of visual discrimination
    Peter Sterling; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Neural signaling employs many stochastic processes (transmitter release, receptor binding, channel opening) that might add noise and thus lose information...
  25. Age-related epigenetic gene silencing in the RPE
    LEONARD HJELMELAND; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  26. Survival Analysis Methods for Transplantation Studies
    DOROTA DABROWSKA; Fiscal Year: 2009
    ..We consider prediction of patient post-transplant experience based on pre-transplant characteristics and follow-up history. ..
  27. Stochastic Nonlinear Dynamics of Sensory Nervous Systems
    David Russell; Fiscal Year: 2004
    ..of the proposed research is to gain a better understanding of the functional roles of nonlinear and stochastic processes in neural mechanisms of information processing in the sensory nervous systems of vertebrates...
  28. HUMAN B CELL DIFFERENTIATION IN A MODEL SYSTEM
    LORI COVEY; Fiscal Year: 1999
    ..We will identify the rearrangement status of the non- productive allele after simulation with cytokines and T cell contact. ..
  29. ACTIVE LIFE EXPECTANCY IN OLD AND OLDEST OLD POPULATIONS
    Kenneth Manton; Fiscal Year: 2002
    ..Using the detailed measures of disability made in each NLTCS wave, the project will examine more refined changes in specific types and intensity of disability and differences over age, race, gender, and education. ..
  30. ANALYSIS OF EARNING INEQUALITY AND EARNINGS MOBILITY
    DOUGLAS GALE; Fiscal Year: 2002
    ..will use data from the 1969-1996 waves of the Panel Study of Income Dynamics (PSID) to examine how the stochastic processes for earnings of men and income women have shifted over this period...
  31. RETRIEVAL PROCESSES IN MEMORY
    Roger Ratcliff; Fiscal Year: 2004
    ..Reaction time models especially might lead to diagnostic techniques that are non-invasive and relatively inexpensive. ..
  32. STATISTICAL METHODS IN AIDS RESEARCH
    Jeremy Taylor; Fiscal Year: 1999
    ..The methods in both projects will be evaluated and compared to other approaches on simulated, clinical trial and Multicenter AIDS Cohort Study (MACS) data. The methodology has wide applicability to both AIDS and non-AIDS studies. ..
  33. Transition Model for Incomplete Longitudinal Binary Data
    Xiaowei Yang; Fiscal Year: 2003
    ..In MLM approach, status of missingness is treated as a third category to extend the repeated measures into three-category ones. ..
  34. PATTERNS OF DECLINE IN NURSING HOME PATIENTS
    WALTER FREIBERGER; Fiscal Year: 1993
    ..Study results will include improvements in the methods of estimation of the probabilities of ADL transition, the expected duration of stay in each level, and the expected length of stay in the nursing home prior to discharge or death...
  35. EPIDEMIC PROCESSES, ESTIMATION AND SEQUENTIAL ANALYSIS
    LYNNE BILLARD; Fiscal Year: 1980
    ..1) is with epidemic models, the mathematics to be developed will also be widely applicable to many other stochastic processes. The work on estimation procedures will be concerned largely with maximum likelihood, empirical Bayes and ..
  36. Mechanisms of visual memory decay
    Jason Gold; Fiscal Year: 2005
    ..g., making comparisons amongst X-ray displays, etc.). ..
  37. SENESCENCE IN HUMAN T LYMPHOCYTE CULTURES
    Rita Effros; Fiscal Year: 1992
    ..Since one of the central phenomena of mammalian aging is the immune decline at the organismal level, T lymphocytes represent and eminently suitable model to further explore in vitro senescence...
  38. POPULATION STABILITY IN TUMOR DORMANCY
    Richard Scheuermann; Fiscal Year: 2002
    ..that results in long term population stability in culture is achieved by an overall balance between two stochastic processes in the population or as directed process involving asymmetric cell division. 3...
  39. STATISTICAL METHODS FOR CANCER CLINICAL TRIALS
    JOHN LACHINE; Fiscal Year: 1999
    ..David DeMets of the University of Wisconsin Clinical Cancer Center and Dr. Timothy Chen of the National Cancer Institutes. ..
  40. Inflammatory Processes in Aging Drosophila
    Scott Pletcher; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  41. Demographic Change and Dependent Social Structures
    James Jones; Fiscal Year: 2009
    ..abstract_text> ..
  42. STATISTICAL METHODS FOR ANALYSIS OF FAILURE TIME DATA
    Rebecca Betensky; Fiscal Year: 2002
    ..To accomplish these aims, local likelihood estimation, multiple imputation, estimating equations, approximations of first passage time distributions for continuous stochastic processes, and convex optimization theory will be used.
  43. A signal transduction pathway database/modeling system
    Eric Mjolsness; Fiscal Year: 2006
    ..3) Ingest and store results from computational simulations and provide tools for comparing, visualizing and mining simulation results. ..
  44. DYNAMIC DETERMINANTS OF EXCEPTIONAL HEALTH AT LATE AGES
    ANATOLIY YASHIN; Fiscal Year: 2009
    ..Evaluate contribution of genetic and non-genetic factors in exceptional health at late ages in the joint analysis of FHS and FHSO data. ..
  45. Mathematical Models of Programmed CTL Proliferation
    Dominik Wodarz; Fiscal Year: 2009
    ..These are the role of effector molecules (such as perform and IFN-g) for CTL dynamics, and the role of CD4 T cell help. The modeling work will be complemented by experiments with VSV and LCMV infected mice. ..
  46. Semiparametric Regression Analysis of Censored Data
    Danyu Lin; Fiscal Year: 2004
    ..Applications to real medical studies will be provided. The research results will be disseminated to practicing statisticians and medical investigators via publications, lectures and software distributions. ..
  47. CYTOGENETIC MODELS FOR ASSESSING LOW DOSE RADIATION RISK
    Rainer Sachs; Fiscal Year: 2001
    ..By studying molecular, mechanisms relevant to low doses and low dose-rates quantitatively the project will help firm-up risk estimates and make them more credible. ..
  48. Evolution of Disease: Current patterns and future trends
    Matthew Keeling; Fiscal Year: 2006
    ..The types of trade-offs and constraints seen in the experimental systems can then be used to formulated more biologically mechanistic and more accurate computer models of disease evolution in higher organisms. ..
  49. Towards Quantitative Study of Systems Biology
    Ping Ao; Fiscal Year: 2007
    ..Additional funds will be aggressively sought to support the project. The execution of the research plan will provide the needed opportunity to deepen my understanding of systems biology. [unreadable] [unreadable] [unreadable]..
  50. New Methods of Studying Aging, Health and Longevity: Combining Longitudinal Data
    ANATOLIY I YASHIN; Fiscal Year: 2010
    ....
  51. Updating Chromosome Aberration Simulator (CAS) Software
    Rainer Sachs; Fiscal Year: 2006
    ..An interdisciplinary team has been assembled for this project. The grant would ensure that a computer resource important to the radiation cytogenetics community is kept fully current and readily available. ..
  52. Power and Sample Size for Microarray Studies
    Mei Ling Lee; Fiscal Year: 2004
    ..Aim 3. Develop software for computing power and sample size for different experimental designs. Aim 4. Demonstrate application of the derived methodology in several practical studies. ..
  53. Auditory Information Processing of Temporal Modulation
    Stanley Sheft; Fiscal Year: 2007
    ..Multi-message conditions are studied to evaluate the extent to which modulation information can be segregated by source and still utilized in a meaningful way. ..
  54. MOLECULAR MECHANISMS IN NEOPLASIA
    Paul Neiman; Fiscal Year: 2008
    ..In this fashion we hope to establish whether Myc-induced genomic instability merits wider exploration in human neoplasm. [unreadable] [unreadable] [unreadable] [unreadable]..
  55. Growth Hormone Secretory Dynamics in Peripubertal Girls
    Steven Pincus; Fiscal Year: 2002
    ..In particular, collaborations with pharmaceutical companies who manufacture growth hormone. ..
  56. Transport and Complexity in Biological Systems
    ARTHUR LANDER; Fiscal Year: 2004
    ..abstract_text> ..
  57. NEW FUNCTIONAL MODELS FOR BIOMEDICAL DATA
    Wensheng Guo; Fiscal Year: 2009
    ..The proposed methods are motivated by and will be applied to the clinical studies that the principal investigator is directly or indirectly involved. ..
  58. FMRI Investigations of Anterior Temporal Lobe Function
    Colin Humphries; Fiscal Year: 2006
    ..Finally, the third experiment will investigate the influence of prosody on ATSA activation. We predict that disrupting sentence prosody will affect activation levels in the ATSA. ..
  59. Genetics of Susceptibility to MMTV-Induced Mammary Tumor
    Susan Ross; Fiscal Year: 2006
    ..The results obtained from these studies will greatly increase our understanding of the genetic mechanisms which viruses use to infect their hosts and how genetic resistance to such viruses in the hosts occurs. ..
  60. Aging-Related Models and Mitochondrial Bioenergetics
    David Nicholls; Fiscal Year: 2006
    ..3. To indicate therapeutic strategies whereby the deleterious consequences of aging-related changes in mitochondrial function can be minimized. ..
  61. Calcium Waves in Atrial Cells
    Leighton Izu; Fiscal Year: 2005
    ..A quantitative model of the atrial Ca control system is necessary for understanding both normal E-C coupling and the origins of pathological spontaneous Ca waves, which recent data suggest can trigger atrial arrhythmias. ..