proportional hazards models

Summary

Summary: Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.

Top Publications

  1. ncbi Prediction of coronary heart disease using risk factor categories
    P W Wilson
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Mass 01701, USA
    Circulation 97:1837-47. 1998
  2. ncbi A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer
    Soonmyung Paik
    Division of Pathology, Operation Center, and the Biostatistics Center, National Surgical Adjuvant Breast and Bowel Project, Pittsburgh 15212, USA
    N Engl J Med 351:2817-26. 2004
  3. ncbi A gene-expression signature as a predictor of survival in breast cancer
    Marc J van de Vijver
    Division of Diagnostic Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands
    N Engl J Med 347:1999-2009. 2002
  4. ncbi Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
    Edward H Romond
    National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, USA
    N Engl J Med 353:1673-84. 2005
  5. ncbi Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old
    Kenneth F Adams
    Nutritional Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    N Engl J Med 355:763-78. 2006
  6. doi Effects of intensive glucose lowering in type 2 diabetes
    Hertzel C Gerstein
    N Engl J Med 358:2545-59. 2008
  7. ncbi General and abdominal adiposity and risk of death in Europe
    T Pischon
    Department of Epidemiology, German Institute of Human Nutrition, Potsdam Rehbruecke, Germany
    N Engl J Med 359:2105-20. 2008
  8. doi Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes
    Anushka Patel
    N Engl J Med 358:2560-72. 2008
  9. pmc Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study
    I M Stratton
    Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Radcliffe Infirmary, Oxford OX2 6HE
    BMJ 321:405-12. 2000
  10. ncbi The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men
    Hanna Maaria Lakka
    Research Institute of Public Health, University of Kuopio, Finland
    JAMA 288:2709-16. 2002

Detail Information

Publications357 found, 100 shown here

  1. ncbi Prediction of coronary heart disease using risk factor categories
    P W Wilson
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Mass 01701, USA
    Circulation 97:1837-47. 1998
    ....
  2. ncbi A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer
    Soonmyung Paik
    Division of Pathology, Operation Center, and the Biostatistics Center, National Surgical Adjuvant Breast and Bowel Project, Pittsburgh 15212, USA
    N Engl J Med 351:2817-26. 2004
    ..The likelihood of distant recurrence in patients with breast cancer who have no involved lymph nodes and estrogen-receptor-positive tumors is poorly defined by clinical and histopathological measures...
  3. ncbi A gene-expression signature as a predictor of survival in breast cancer
    Marc J van de Vijver
    Division of Diagnostic Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands
    N Engl J Med 347:1999-2009. 2002
    ..A more accurate means of prognostication in breast cancer will improve the selection of patients for adjuvant systemic therapy...
  4. ncbi Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
    Edward H Romond
    National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, USA
    N Engl J Med 353:1673-84. 2005
    ..We present the combined results of two trials that compared adjuvant chemotherapy with or without concurrent trastuzumab in women with surgically removed HER2-positive breast cancer...
  5. ncbi Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old
    Kenneth F Adams
    Nutritional Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    N Engl J Med 355:763-78. 2006
    ..0 or more, is associated with an increased risk of death, but the relation between overweight (a BMI of 25.0 to 29.9) and the risk of death has been questioned...
  6. doi Effects of intensive glucose lowering in type 2 diabetes
    Hertzel C Gerstein
    N Engl J Med 358:2545-59. 2008
    ....
  7. ncbi General and abdominal adiposity and risk of death in Europe
    T Pischon
    Department of Epidemiology, German Institute of Human Nutrition, Potsdam Rehbruecke, Germany
    N Engl J Med 359:2105-20. 2008
    ....
  8. doi Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes
    Anushka Patel
    N Engl J Med 358:2560-72. 2008
    ..In patients with type 2 diabetes, the effects of intensive glucose control on vascular outcomes remain uncertain...
  9. pmc Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study
    I M Stratton
    Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Radcliffe Infirmary, Oxford OX2 6HE
    BMJ 321:405-12. 2000
    ..To determine the relation between exposure to glycaemia over time and the risk of macrovascular or microvascular complications in patients with type 2 diabetes...
  10. ncbi The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men
    Hanna Maaria Lakka
    Research Institute of Public Health, University of Kuopio, Finland
    JAMA 288:2709-16. 2002
    ..Despite its high prevalence, little is known of the prospective association of the metabolic syndrome with cardiovascular and overall mortality...
  11. ncbi Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial
    Jacques E Rossouw
    Division of Women s Health Initiative, National Heart, Lung, and Blood Institute, 6705 Rockledge Dr, One Rockledge Ctr, Suite 300, Bethesda, MD 20817
    JAMA 288:321-33. 2002
    ..Despite decades of accumulated observational evidence, the balance of risks and benefits for hormone use in healthy postmenopausal women remains uncertain...
  12. pmc Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adults
    Elizabeth Selvin
    Department of Epidemiology and the Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21287, USA
    N Engl J Med 362:800-11. 2010
    ..Fasting glucose is the standard measure used to diagnose diabetes in the United States. Recently, glycated hemoglobin was also recommended for this purpose...
  13. ncbi DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy
    Ken A Olaussen
    Laboratory of Radiobiology and Oncology, Commissariat a l Energie Atomique, Fontenay aux Roses, University of Paris 11, Paris, France
    N Engl J Med 355:983-91. 2006
    ..Adjuvant cisplatin-based chemotherapy improves survival among patients with completely resected non-small-cell lung cancer, but there is no validated clinical or biologic predictor of the benefit of chemotherapy...
  14. pmc Early loss of HIV-infected patients on potent antiretroviral therapy programmes in lower-income countries
    Martin W G Brinkhof
    Institute of Social and Preventive Medicine, Bern, Switzerland
    Bull World Health Organ 86:559-67. 2008
    ..To analyse the early loss of patients to antiretroviral therapy (ART) programmes in resource-limited settings...
  15. pmc Association between body-mass index and risk of death in more than 1 million Asians
    Wei Zheng
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA
    N Engl J Med 364:719-29. 2011
    ..Most studies that have evaluated the association between the body-mass index (BMI) and the risks of death from any cause and from specific causes have been conducted in populations of European origin...
  16. ncbi Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer
    Soonmyung Paik
    Division of Pathology, Operations Center, and Biostatistical Center, National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA 15212, USA
    J Clin Oncol 24:3726-34. 2006
    ..The relationship between the RS and chemotherapy benefit is not known...
  17. ncbi Relation between renal dysfunction and cardiovascular outcomes after myocardial infarction
    Nagesh S Anavekar
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 351:1285-95. 2004
    ..Renal failure is associated with one of the highest risks, but the influence of milder degrees of renal impairment is less well defined...
  18. pmc Subtyping of breast cancer by immunohistochemistry to investigate a relationship between subtype and short and long term survival: a collaborative analysis of data for 10,159 cases from 12 studies
    Fiona M Blows
    Department of Oncology, University of Cambridge, United Kingdom
    PLoS Med 7:e1000279. 2010
    ....
  19. ncbi Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis
    Christos Sotiriou
    Functional Genomics and Translational Research Unit, Universite Libre de Bruxelles, Brussels, Belgium
    J Natl Cancer Inst 98:262-72. 2006
    ..We examined whether histologic grade was associated with gene expression profiles of breast cancers and whether such profiles could be used to improve histologic grading...
  20. ncbi Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin
    Samantha L Bowker
    Institute of Health Economics, Edmonton, Alberta, Canada
    Diabetes Care 29:254-8. 2006
    ..We explored the association between antidiabetic therapies and cancer-related mortality in patients with type 2 diabetes, postulating that agents that increase insulin levels might promote cancer...
  21. ncbi Chronic kidney disease and mortality risk: a systematic review
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, Alberta T6B 2B7, Canada
    J Am Soc Nephrol 17:2034-47. 2006
    ..0 in 71% of cohorts. This review supports current guidelines that identify individuals with CKD as being at high risk for cardiovascular mortality. Determining which interventions best offset this risk remains a health priority...
  22. ncbi Simple scoring scheme for calculating the risk of acute coronary events based on the 10-year follow-up of the prospective cardiovascular Münster (PROCAM) study
    Gerd Assmann
    Institute of Arteriosclerosis Research at the University of Münster, Germany
    Circulation 105:310-5. 2002
    ..Although several scoring schemes have been suggested to calculate this profile, many omit information on important variables such as family history of coronary heart disease or LDL cholesterol...
  23. ncbi Neutrophil-lymphocyte ratio as a prognostic factor in colorectal cancer
    S R Walsh
    Department of Colorectal Surgery, West Suffolk Hospital NHS Trust, UK
    J Surg Oncol 91:181-4. 2005
    ..Simple methods to identify colorectal cancer patients at risk of recurrence are needed. This study aimed to determine if neutrophil-to-lymphocyte ratio (NLR) predicts survival in colorectal cancer patients...
  24. ncbi Survival as a function of HbA(1c) in people with type 2 diabetes: a retrospective cohort study
    Craig J Currie
    Department of Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Lancet 375:481-9. 2010
    ..Results of intervention studies in patients with type 2 diabetes have led to concerns about the safety of aiming for normal blood glucose concentrations. We assessed survival as a function of HbA(1c) in people with type 2 diabetes...
  25. ncbi Survival model predictive accuracy and ROC curves
    Patrick J Heagerty
    Department of Biostatistics, University of Washington, P O Box 357232, Seattle, Washington 98195 7232, USA
    Biometrics 61:92-105. 2005
    ..Semiparametric estimation methods appropriate for both proportional and nonproportional hazards data are introduced, evaluated in simulations, and illustrated using two familiar survival data sets...
  26. pmc Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes
    David M Nathan
    N Engl J Med 353:2643-53. 2005
    ..We studied whether the use of intensive therapy as compared with conventional therapy during the Diabetes Control and Complications Trial (DCCT) affected the long-term incidence of cardiovascular disease...
  27. ncbi Capecitabine and oxaliplatin for advanced esophagogastric cancer
    David Cunningham
    Royal Marsden Hospital National Health Service Foundation Trust, Surrey and London, United Kingdom
    N Engl J Med 358:36-46. 2008
    ..We evaluated capecitabine (an oral fluoropyrimidine) and oxaliplatin (a platinum compound) as alternatives to infused fluorouracil and cisplatin, respectively, for untreated advanced esophagogastric cancer...
  28. ncbi Optimal medical therapy with or without PCI for stable coronary disease
    William E Boden
    Western New York Veterans Affairs Healthcare Network and Buffalo General Hospital SUNY, Buffalo, NY 14203, USA
    N Engl J Med 356:1503-16. 2007
    ....
  29. pmc Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studies
    Marianne U Jakobsen
    Research Unit for Dietary Studies at the Institute of Preventive Medicine, Copenhagen University Hospital, Centre for Health and Society, Copenhagen, Denmark
    Am J Clin Nutr 89:1425-32. 2009
    ..Lower habitual intakes of SFAs, however, require substitution of other macronutrients to maintain energy balance...
  30. ncbi Cause-specific excess deaths associated with underweight, overweight, and obesity
    Katherine M Flegal
    National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD 20782, USA
    JAMA 298:2028-37. 2007
    ..The association of body mass index (BMI) with cause-specific mortality has not been reported for the US population...
  31. ncbi Histopathologic-based prognostic factors of colorectal cancers are associated with the state of the local immune reaction
    Bernhard Mlecnik
    Inserm U872, Integrative Cancer Immunology Team, 15 rue de l Ecole de Medecine, Centre de Recherche des Cordeliers, 75006 Paris, France
    J Clin Oncol 29:610-8. 2011
    ....
  32. ncbi Flexible parametric proportional-hazards and proportional-odds models for censored survival data, with application to prognostic modelling and estimation of treatment effects
    Patrick Royston
    Cancer Division, MRC Clinical Trials Unit, 222 Euston Road, London NW1 2DA, UK
    Stat Med 21:2175-97. 2002
    ..The tools described here may be a step towards providing greater insight into the natural history of the disease and into possible underlying causes of clinical events. We illustrate these aspects by using the two examples in cancer...
  33. pmc Gene expression-based prognostic signatures in lung cancer: ready for clinical use?
    Jyothi Subramanian
    Biometric Research Branch, Department of Cancer Treatment and Diagnosis, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892 7434, USA
    J Natl Cancer Inst 102:464-74. 2010
    ....
  34. ncbi Body mass index and mortality: a meta-analysis based on person-level data from twenty-six observational studies
    Daniel L McGee
    Department of Statistics, Florida State University, Tallahassee, FL 32306 4330, USA
    Ann Epidemiol 15:87-97. 2005
    ..For this report, we examined the relationships between the conditions of being overweight and obese and mortality from all causes, heart disease, cardiovascular disease, and cancer...
  35. ncbi L1 penalized estimation in the Cox proportional hazards model
    Jelle J Goeman
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
    Biom J 52:70-84. 2010
    ..An R package, penalized, that implements the method, is available on CRAN...
  36. ncbi Studies of mortality of atomic bomb survivors. Report 13: Solid cancer and noncancer disease mortality: 1950-1997
    Dale L Preston
    Department of Statistics, Radiation Effects Research Foundation, Hiroshima, Japan
    Radiat Res 160:381-407. 2003
    ..Lifetime risk summaries are used to examine uncertainties of the LSS noncancer disease findings...
  37. pmc Imputing missing covariate values for the Cox model
    Ian R White
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 0SR, UK
    Stat Med 28:1982-98. 2009
    ..We find that using logT biases covariate-outcome associations towards the null, while the new methods have lower bias. Overall, we recommend including the event indicator and the Nelson-Aalen estimator of H(T) in the imputation model...
  38. pmc Novel and conventional biomarkers for prediction of incident cardiovascular events in the community
    Olle Melander
    Department of Clinical Sciences, Lund University, Clinical Research Center, Malmo University Hospital, SE 205 02 Malmo, Sweden
    JAMA 302:49-57. 2009
    ..Prior studies have demonstrated conflicting results regarding how much information novel biomarkers add to cardiovascular risk assessment...
  39. ncbi A randomized, controlled trial of early versus late initiation of dialysis
    Bruce A Cooper
    Department of Renal Medicine, Royal North Shore Hospital, Sydney Medical School, Sydney, Australia
    N Engl J Med 363:609-19. 2010
    ..In this study, conducted at 32 centers in Australia and New Zealand, we examined whether the timing of the initiation of maintenance dialysis influenced survival among patients with chronic kidney disease...
  40. pmc Genomic index of sensitivity to endocrine therapy for breast cancer
    W Fraser Symmans
    Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Clin Oncol 28:4111-9. 2010
    ..We hypothesize that measurement of gene expression related to estrogen receptor α (ER; gene name ESR1) within a breast cancer sample represents intrinsic tumoral sensitivity to adjuvant endocrine therapy...
  41. ncbi Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 359:2195-207. 2008
    ....
  42. ncbi Long-term exposure to air pollution and incidence of cardiovascular events in women
    Kristin A Miller
    Department of Epidemiology, University of Washington, Seattle, USA
    N Engl J Med 356:447-58. 2007
    ..We examined the association of long-term exposure to particulate matter of less than 2.5 microm in aerodynamic diameter (PM2.5) with cardiovascular events...
  43. ncbi The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma
    Andreas Rosenwald
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    N Engl J Med 346:1937-47. 2002
    ..The survival of patients with diffuse large-B-cell lymphoma after chemotherapy is influenced by molecular features of the tumors. We used the gene-expression profiles of these lymphomas to develop a molecular predictor of survival...
  44. ncbi Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events
    P M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 344:1959-65. 2001
    ..We hypothesized that statins might prevent coronary events in persons with elevated C-reactive protein levels who did not have overt hyperlipidemia...
  45. ncbi Gene expression profiling of primary cutaneous melanoma and clinical outcome
    Veronique Winnepenninckx
    Department of Pathology, Gustave Roussy Institute, 94805 Villejuif Cedex, France
    J Natl Cancer Inst 98:472-82. 2006
    ..To identify differentially expressed genes that may be involved in melanoma progression and prognosis, we investigated the relationship between gene expression profiles and clinical outcome in a cohort of patients with primary melanoma...
  46. ncbi Relation between serum phosphate level and cardiovascular event rate in people with coronary disease
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Circulation 112:2627-33. 2005
    ..Given the biological importance of phosphorus, it is plausible that higher levels of serum phosphate within the normal range may also be associated with adverse outcomes...
  47. ncbi Intensive versus moderate lipid lowering with statins after acute coronary syndromes
    Christopher P Cannon
    Thrombolysis in Myocardial Infarction TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 350:1495-504. 2004
    ..Lipid-lowering therapy with statins reduces the risk of cardiovascular events, but the optimal level of low-density lipoprotein (LDL) cholesterol is unclear...
  48. ncbi Generating survival times to simulate Cox proportional hazards models
    Ralf Bender
    Institute for Quality and Efficiency in Health Care, Cologne, Germany
    Stat Med 24:1713-23. 2005
    ..In this paper, techniques to generate survival times for simulation studies regarding Cox proportional hazards models are presented...
  49. pmc Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution
    C Arden Pope
    Department of Economics, Brigham Young University, 142 FOB, Provo, UT 84602, USA
    JAMA 287:1132-41. 2002
    ..However, studies of health effects of long-term particulate air pollution have been less conclusive...
  50. ncbi Dyspnea is a better predictor of 5-year survival than airway obstruction in patients with COPD
    Koichi Nishimura
    Respiratory Division, Kyoto Katsura Hospital, Kyoto, Japan
    Chest 121:1434-40. 2002
    ....
  51. ncbi A five-gene signature and clinical outcome in non-small-cell lung cancer
    Hsuan Yu Chen
    National Taiwan University College of Public Health, National Taiwan University College of Medicine, Taipei, Taiwan
    N Engl J Med 356:11-20. 2007
    ..Current staging methods are inadequate for predicting the outcome of treatment of non-small-cell lung cancer (NSCLC). We developed a five-gene signature that is closely associated with survival of patients with NSCLC...
  52. ncbi Choice of time-scale in Cox's model analysis of epidemiologic cohort data: a simulation study
    Anne C M Thiebaut
    INSERM, E3N EPIC, Institut Gustave Roussy, Villejuif, France
    Stat Med 23:3803-20. 2004
    ..In view of our results, we strongly recommend not using time-on-study as the time-scale for analysing epidemiologic cohort data...
  53. ncbi Natural history and possible reactivation of human papillomavirus in human immunodeficiency virus-positive women
    Howard D Strickler
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Ave, Belfer 1308, Bronx, NY 10461, USA
    J Natl Cancer Inst 97:577-86. 2005
    ....
  54. ncbi HLA-DRB1 and persistent chronic inflammation contribute to cardiovascular events and cardiovascular mortality in patients with rheumatoid arthritis
    Miguel A Gonzalez-Gay
    Hospital Xeral Calde, Lugo, Spain
    Arthritis Rheum 57:125-32. 2007
    ..We assessed the contribution of epidemiologic features, clinical features, routine laboratory markers of inflammation, and HLA-DRB1 alleles to CV mortality in patients with RA prospectively followed at a single referral center in Spain...
  55. ncbi Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer
    E Kapiteijn
    Department of Surgery, Leiden University Medical Center, The Netherlands
    N Engl J Med 345:638-46. 2001
    ..2 percent in the surgery-only group (P<0.001). CONCLUSIONS: Short-term preoperative radiotherapy reduces the risk of local recurrence in patients with rectal cancer who undergo a standardized total mesorectal excision...
  56. pmc Total cholesterol and cancer risk in a large prospective study in Korea
    Cari M Kitahara
    National Cancer Institute, National Institutes of Health, Rockville, MD, USA
    J Clin Oncol 29:1592-8. 2011
    ..To further clarify the relationship between total cholesterol and cancer, which remains unclear...
  57. ncbi Carcinoma of the ovary. FIGO 26th Annual Report on the Results of Treatment in Gynecological Cancer
    A P M Heintz
    Int J Gynaecol Obstet 95:S161-92. 2006
  58. ncbi Multiple biomarkers for the prediction of first major cardiovascular events and death
    Thomas J Wang
    Framingham Heart Study, Framingham, MA, USA
    N Engl J Med 355:2631-9. 2006
    ..Few investigations have evaluated the incremental usefulness of multiple biomarkers from distinct biologic pathways for predicting the risk of cardiovascular events...
  59. ncbi Cyclin E and survival in patients with breast cancer
    Khandan Keyomarsi
    Department of Experimental Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston 77030 4095, USA
    N Engl J Med 347:1566-75. 2002
    ..Cyclin E, a regulator of the cell cycle, affects the behavior of breast-cancer cells. We investigated whether levels of cyclin E in the tumor correlated with survival among patients with breast cancer...
  60. ncbi Long-term clinical course of patients after termination of ventricular tachyarrhythmia by an implanted defibrillator
    Arthur J Moss
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Circulation 110:3760-5. 2004
    ..This analysis from the MADIT-II trial database examines the long-term clinical course and subsequent mortality risk of patients after termination of life-threatening ventricular tachyarrhythmias by an ICD...
  61. ncbi Body fat distribution and risk of coronary heart disease in men and women in the European Prospective Investigation Into Cancer and Nutrition in Norfolk cohort: a population-based prospective study
    Dexter Canoy
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Circulation 116:2933-43. 2007
    ..Body fat distribution has been cross-sectionally associated with atherosclerotic disease risk factors, but the prospective relation with coronary heart disease remains uncertain...
  62. pmc Intraepithelial effector (CD3+)/regulatory (FoxP3+) T-cell ratio predicts a clinical outcome of human colon carcinoma
    Frank A Sinicrope
    Miles and Shirley Fiterman Digestive Disease Center, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Gastroenterology 137:1270-9. 2009
    ..We investigated whether the intratumoral densities of FoxP3(+) and effector CD3(+) lymphocytes are associated with prognosis of patients with colon cancer...
  63. ncbi Prognostic model for predicting survival in men with hormone-refractory metastatic prostate cancer
    Susan Halabi
    Department of Biostatistics and Bioinformatics and CALGB Statistical Center, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Oncol 21:1232-7. 2003
    ..To develop and validate a model that can be used to predict the overall survival probability among metastatic hormone-refractory prostate cancer patients (HRPC)...
  64. ncbi Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial) [corrected]
    Masahiro Fukuoka
    Fourth Department of Internal Medicine, Kinki University School of Medicine, 377 2 Ohnohigashi Osakasayama, Osaka 589, Japan
    J Clin Oncol 21:2237-46. 2003
    ....
  65. ncbi Abdominal adiposity and coronary heart disease in women
    K M Rexrode
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02215, USA
    JAMA 280:1843-8. 1998
    ..Obesity is a well-established risk factor for coronary heart disease (CHD), but whether regional fat distribution contributes independently to risk remains unclear...
  66. ncbi Prognostic models with competing risks: methods and application to coronary risk prediction
    Marcel Wolbers
    Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland
    Epidemiology 20:555-61. 2009
    ..ignores the competing risk of non-CHD death, and (2) a cause-specific hazards model, which combines proportional hazards models for the event of interest and the competing event...
  67. ncbi A gene expression signature identifies two prognostic subgroups of basal breast cancer
    Renaud Sabatier
    Département d Oncologie Moléculaire, Centre de Recherche en Cancerologie de Marseille, UMR891 Inserm, Institut Paoli Calmettes, Marseille, France
    Breast Cancer Res Treat 126:407-20. 2011
    ..This signature could help define the prognosis, adapt the systemic treatment, and identify new therapeutic targets...
  68. ncbi Red cell distribution width in heart failure: prediction of clinical events and relationship with markers of ineffective erythropoiesis, inflammation, renal function, and nutritional state
    Zsolt Förhécz
    3rd Department of Internal Medicine, and Szentágothai Knowledge Center, Semmelweis University, Budapest, Hungary
    Am Heart J 158:659-66. 2009
    ..Understanding the mechanism underlying this observation is unclear, largely hampered by the lack of epidemiologic studies demonstrating factors that are associated with anisocytosis in cardiovascular diseases...
  69. ncbi Residual risk of breast cancer recurrence 5 years after adjuvant therapy
    Abenaa M Brewster
    Departments of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    J Natl Cancer Inst 100:1179-83. 2008
    ..Breast cancer patients have a substantial residual risk of recurrence, and selected tumor characteristics are associated with late recurrences...
  70. ncbi Excess deaths associated with underweight, overweight, and obesity
    Katherine M Flegal
    National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD 20782, USA
    JAMA 293:1861-7. 2005
    ..As the prevalence of obesity increases in the United States, concern over the association of body weight with excess mortality has also increased...
  71. pmc Competing risk regression models for epidemiologic data
    Bryan Lau
    Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    Am J Epidemiol 170:244-56. 2009
    ..71, 95% confidence interval: 1.37, 2.13 and (sd)RH = 2.01, 95% confidence interval: 1.62, 2.51). Methods for competing risks should be used by epidemiologists, with the choice of method guided by the scientific question...
  72. ncbi Sex differences in mortality and clinical expressions of patients with chronic obstructive pulmonary disease. The TORCH experience
    Bartolome Celli
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 183:317-22. 2011
    ..There is limited knowledge regarding sex differences and outcomes in patients with chronic obstructive pulmonary disease (COPD)...
  73. ncbi The number of years lived with obesity and the risk of all-cause and cause-specific mortality
    Asnawi Abdullah
    Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Vic, Australia
    Int J Epidemiol 40:985-96. 2011
    ..The role of the duration of obesity as an independent risk factor for mortality has not been investigated. The aim of this study was to analyse the association between the duration of obesity and the risk of mortality...
  74. ncbi Association of hyperuricemia with renal outcomes, cardiovascular disease, and mortality
    Wan Chun Liu
    Department of Internal Medicine, Kaohsiung Municipal Hsiao Kang Hospital, Taiwan
    Clin J Am Soc Nephrol 7:541-8. 2012
    ..Hyperuricemia is an independent risk factor for mortality, cardiovascular disease, and renal disease in general population. However, the relationship between hyperuricemia with clinical outcomes in CKD remains controversial...
  75. ncbi Gene expression profiling reveals a new classification of adrenocortical tumors and identifies molecular predictors of malignancy and survival
    Aurelien de Reynies
    Service des Maladies Endocriniennes et Metaboliques, Hopital Cochin, 27, rue du Faubourg Saint Jacques, 75014, Paris, France
    J Clin Oncol 27:1108-15. 2009
    ..Adrenocortical tumors, especially cancers, remain challenging both for their diagnosis and prognosis assessment. The aim of this article is to identify molecular predictors of malignancy and of survival...
  76. ncbi Relations of serum phosphorus and calcium levels to the incidence of cardiovascular disease in the community
    Ravi Dhingra
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702 5803, USA
    Arch Intern Med 167:879-85. 2007
    ..However, it is unknown if serum phosphorus levels influence vascular risk in individuals without CKD or CVD...
  77. pmc Plasma omega-3 fatty acids and incident diabetes in older adults
    Luc Djousse
    Division of Aging, Department of Epidemiology, University of Washington, Seattle, WA, USA
    Am J Clin Nutr 94:527-33. 2011
    ....
  78. ncbi Multi-state models for event history analysis
    Per Kragh Andersen
    Department of Biostatistics, University of Copenhagen, Danish Epidemiology Science Centre, Copenhagen, Denmark
    Stat Methods Med Res 11:91-115. 2002
    ..Consequences of observational patterns are discussed, and a real example concerning mortality and bleeding episodes in a liver cirrhosis trial is discussed...
  79. ncbi Tuberculosis and the risk of ischemic stroke: a 3-year follow-up study
    Jau Jiuan Sheu
    Department of Neurology, Taipei Medical University Hospital, Taipei, Taiwan
    Stroke 41:244-9. 2010
    ..The aim of this study is to estimate the risk of ischemic stroke during a 3-year follow-up period after a tuberculosis diagnosis using a nationwide, population-based study and a retrospective cohort design...
  80. ncbi Renal insufficiency and subsequent death resulting from cardiovascular disease in the United States
    Paul Muntner
    Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana 70112, USA
    J Am Soc Nephrol 13:745-53. 2002
    ..This study indicates that, in a representative sample of the United States general population, renal insufficiency is independently associated with increased cardiovascular disease-related and all-cause mortality rates...
  81. ncbi A novel simpler histological classification for renal survival in IgA nephropathy: a retrospective study
    Carlo Manno
    Department of Emergency and Organ Transplantation, Renal, Dialysis and Transplant Unit, University of Bari, Bari, Italy
    Am J Kidney Dis 49:763-75. 2007
    ..We evaluated factors associated with long-term renal survival by using a novel simplified histological classification...
  82. ncbi Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women
    Børge G Nordestgaard
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
    JAMA 298:299-308. 2007
    ..Elevated nonfasting triglycerides indicate the presence of remnant lipoproteins, which may promote atherosclerosis...
  83. pmc Statistical methods for the time-to-event analysis of individual participant data from multiple epidemiological studies
    Simon Thompson
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK
    Int J Epidemiol 39:1345-59. 2010
    ..Meta-analysis of individual participant time-to-event data from multiple prospective epidemiological studies enables detailed investigation of exposure-risk relationships, but involves a number of analytical challenges...
  84. pmc Higher percentage of CD133+ cells is associated with poor prognosis in colon carcinoma patients with stage IIIB
    Chun Yan Li
    Biotherapy Center, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China
    J Transl Med 7:56. 2009
    ....
  85. ncbi Minimal changes of serum creatinine predict prognosis in patients after cardiothoracic surgery: a prospective cohort study
    Andrea Lassnigg
    Department of Cardiothoracic Anesthesia and Intensive Care Medicine, University Hospital of Vienna, Waehrihger Guertel 18 20, A 1090 Vienna, Austria
    J Am Soc Nephrol 15:1597-605. 2004
    ..Any even minimal increase or profound decrease of serum creatinine was associated with a substantial decrease in survival...
  86. ncbi Race and triple negative threats to breast cancer survival: a population-based study in Atlanta, GA
    Mary Jo Lund
    Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Road, NE, Atlanta, GA 30322, USA
    Breast Cancer Res Treat 113:357-70. 2009
    ..This study examines association of the ER/PR/HER2 subtypes with race and breast cancer survival...
  87. ncbi Behavioral determinants as predictors of return to work after long-term sickness absence: an application of the theory of planned behavior
    Sandra Brouwer
    Department of Health Sciences, Section of Social Medicine, Work and Health, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, Building 3217, Room 620, 9713 AV, Groningen, The Netherlands
    J Occup Rehabil 19:166-74. 2009
    ....
  88. ncbi Body-mass index and mortality in Korean men and women
    Sun Ha Jee
    Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea
    N Engl J Med 355:779-87. 2006
    ..Obesity is associated with diverse health risks, but the role of body weight as a risk factor for death remains controversial...
  89. ncbi Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction
    Arthur J Moss
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA
    N Engl J Med 346:877-83. 2002
    ..This randomized trial was designed to evaluate the effect of an implantable defibrillator on survival in such patients...
  90. ncbi Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: a meta-analysis of randomised controlled trials
    Kausik K Ray
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Lancet 373:1765-72. 2009
    ..We undertook a meta-analysis of randomised controlled trials to determine whether intensive treatment is beneficial...
  91. ncbi Survival predictability of time-varying indicators of bone disease in maintenance hemodialysis patients
    K Kalantar-Zadeh
    Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
    Kidney Int 70:771-80. 2006
    ....
  92. ncbi Relaxing the rule of ten events per variable in logistic and Cox regression
    Eric Vittinghoff
    Department of Epidemiology and Biostatistics, University of California San Francisco, 185 Berry Street, San Francisco, CA 94107, USA
    Am J Epidemiol 165:710-8. 2007
    ..They conclude that this rule can be relaxed, in particular for sensitivity analyses undertaken to demonstrate adequate control of confounding...
  93. pmc Comparison of prognostic gene expression signatures for breast cancer
    Benjamin Haibe-Kains
    Functional Genomics Unit, Jules Bordet Institute, Universite Libre de Bruxelles, Brussels, Belgium
    BMC Genomics 9:394. 2008
    ..However, signatures were never compared on an independent population of untreated breast cancer patients, where risk assessment was computed using the original algorithms and microarray platforms...
  94. ncbi Long-term intravenous epoprostenol infusion in primary pulmonary hypertension: prognostic factors and survival
    Olivier Sitbon
    Service de Pneumologie et Reanimation, UPRES EA 2705 on Pulmonary Vascular Diseases, Hopital Antoine Beclere, Universite Paris Sud, Clamart, France
    J Am Coll Cardiol 40:780-8. 2002
    ..We sought to determine the factors associated with long-term survival in patients with primary pulmonary hypertension (PPH) treated with continuous epoprostenol infusion...
  95. pmc Patient survival after D1 and D2 resections for gastric cancer: long-term results of the MRC randomized surgical trial. Surgical Co-operative Group
    A Cuschieri
    University Department of Surgery, Ninewells Hospital and Medical School, Dundee, UK
    Br J Cancer 79:1522-30. 1999
    ..However, the possibility that D2 resection without pancreatico-splenectomy may be better than standard D1 resection cannot be dismissed by the results of this trial...
  96. pmc Building prognostic models for breast cancer patients using clinical variables and hundreds of gene expression signatures
    Cheng Fan
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, USA
    BMC Med Genomics 4:3. 2011
    ..We evaluated whether combining the prognostic powers of standard breast cancer clinical variables with a large set of gene expression signatures could improve on our ability to predict patient outcomes...
  97. pmc Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma
    Robert J Motzer
    Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    J Clin Oncol 27:3584-90. 2009
    ..Final survival analyses and updated results are reported...
  98. ncbi Pulmonary function is a long-term predictor of mortality in the general population: 29-year follow-up of the Buffalo Health Study
    H J Schünemann
    Department of Social and Preventive Medicine, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, NY 14214 3000, USA
    Chest 118:656-64. 2000
    ..The purpose of this study was to investigate the predictive value of pulmonary function by gender after 29 years of follow-up...
  99. ncbi Long-term mortality and recurrent stroke risk among Chinese stroke patients with predominant intracranial atherosclerosis
    Ka Sing Wong
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, SAR
    Stroke 34:2361-6. 2003
    ..The goal of this study was to document the long-term outcome of ischemic stroke patients in a population with predominant intracranial atherosclerosis and risk factors for a recurrent event...
  100. pmc Development of a risk score for atrial fibrillation (Framingham Heart Study): a community-based cohort study
    Renate B Schnabel
    Framingham Heart Study, Framingham, MA, USA Department of Medicine II, Johannes Gutenberg University, Mainz, Germany
    Lancet 373:739-45. 2009
    ..We aimed to develop a risk score to predict individuals' absolute risk of developing the condition, and to provide a framework for researchers to assess new risk markers...
  101. ncbi Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM Program and the Duke Databank
    G Michael Felker
    Duke Clinical Research Institute, Durham, North Carolina, USA
    J Am Coll Cardiol 50:40-7. 2007
    ..The goal of this study was to identify potentially novel laboratory markers of risk in chronic heart failure patients...

Research Grants65

  1. Statistical Innovations in Health Services Research
    Joseph Gardiner; Fiscal Year: 2009
    ..with covariate effects incorporated in transition intensities through multiplicative intensity and proportional hazards models. Heterogeneity due to unobserved or omitted variables is accommodated through random effects, frailties,..
  2. Social Networks &Breast Cancer Prognosis in the Chinese and US Evaluation Study
    Candyce H Kroenke; Fiscal Year: 2013
    ..It is hoped that addressing gaps in the literature will help point to potential avenues through which relationships with network members might be augmented to promote survival, or managed to mitigate costs of social relationships. ..
  3. Environmental Determinants of Cognitive Aging in the WHI Memory Study
    Jiu Chiuan Chen; Fiscal Year: 2013
    ..investigate exposures to ambient air pollutants as novel environmental determinants of cognitive aging to better understand the later-life environmental influence on brain aging and subsequent risk of cognitive impairment and dementia ..
  4. Effectiveness of Second Line Hypoglycemic Medications Among Veterans
    Christianne Roumie; Fiscal Year: 2013
    ..We will use the marginal structural Cox proportional hazards models (MSM) using "stabilized" Inverse probability treatment weights (IPTW)...
  5. Access to Liver Transplantation for Patients with Primary Sclerosing Cholangitis
    David Seth Goldberg; Fiscal Year: 2011
    ....
  6. Health decline in aged caregivers: epidemiologic study
    Lisa Fredman; Fiscal Year: 2013
    ..We will use mixed longitudinal models and Cox proportional hazards models to test four hypotheses in all participants and in caregivers only...
  7. Cardiovascular and Prostatic Safety of Testosterone Therapy in Aging Males
    Stephen K Van Den Eeden; Fiscal Year: 2013
    ..In addition to conventional proportional hazards models a Propensity Score Analysis and/or an Instrumental Variable Analysis will be used to identify and ..
  8. Ambulatory Case and Preventable Hospitalizations in Diabetic Kidney Disease
    Chin Lin Tseng; Fiscal Year: 2013
    ..Cox proportional hazards models will be used to evaluate the associations of consistency of subspecialty care and other independent ..
  9. Arsenic Exposure, Cardiovascular Disease and Diabetes in Native Americans
    Ana Navas-Acien; Fiscal Year: 2011
    ..The elucidation of the contribution of arsenic exposure to cardiovascular and diabetes development in this high-quality prospective cohort study can inform and potentially impact current environmental public health recommendations. ..
  10. CVD Predictors of Cognitive Function Trajectory over 20 Years
    Elizabeth L Barrett Connor; Fiscal Year: 2010
    ..This information is important given the aging of the population, the fact that CVD risk factors are modifiable, and because the maintenance of cognitive function is an essential component of healthy aging. ..
  11. MOBILITY AMONG OLDER AFRICAN AMERICANS AND WHITES
    RICHARD MARK ALLMAN; Fiscal Year: 2013
    ..or random-effects regression models will be used to examine life-space trajectories over time and Cox proportional hazards models to evaluate predictors of adverse outcomes...
  12. MEASUREMENT ERRORS IN ENVIRONMENTAL EPIDEMIOLOGY
    DONNA L SPIEGELMAN; Fiscal Year: 2013
    ..The biomarker data available in NHS and MESA-AIR will be used to improve the exposure validation. User- friendly software will be posted on the web, facilitating widescale application of the new methods. ..
  13. Obesity, Aging, and Cancer Cost (OACC) Study
    Benjamin M Craig; Fiscal Year: 2010
    ....
  14. Prevalence and Correlates of Khat Use Among HIV-Positive Patients in Ethiopia
    Alan R Lifson; Fiscal Year: 2013
    ..Our primary hypothesis is that current use of khat is associated with poorer retention in care. Proportional hazards models will be used to estimate associations between covariates and retention, and multivariate models use to ..
  15. Pesticide Use & Breast Cancer Risk in Large Cohort of Female Agriculture Workers
    LAWRENCE STUART ENGEL; Fiscal Year: 2010
    ..Relative risks will be estimated using data from both interviews (pre-diagnostic only), via Cox proportional hazards models including the full cohort, as well as separately by menopausal status and state of residence...
  16. The Quality of Buprenorphine Treatment for Medicaid Beneficiaries
    Jeffrey D Baxter; Fiscal Year: 2013
    ..Finally, for aim 3, using Cox proportional hazards models we will measure the association between receiving care according to treatment guidelines and outcomes ..
  17. Modifiable and Biochemical Predictors and Consequences of Acute Kidney Injury
    Amanda Hyre Anderson; Fiscal Year: 2013
    ..All proposed investigations will occur within the cohort framework of the CRIC Study utilizing Cox proportional hazards models, mixed effects growth curve models, and marginal structural models with time-updated exposures...
  18. Markers of transition to Alzheimer disease in veterans with MCI
    Mary Sano; Fiscal Year: 2013
    ..It will address the question of which tests and diagnostic approaches have the greatest value in predicting Alzheimer disease and clinical decline. ..
  19. Health of Children Born by Mothers with Pheumatoid Arthritis
    Jorn Olsen; Fiscal Year: 2012
    ..The study may also provide additional information on the potential fetotoxic effects of drugs used in treating RA. ..
  20. Macroeconomic Conditions and Marital Dissolution
    MELINDA SANDLER MORRILL; Fiscal Year: 2011
    ..It will demonstrate how macroeconomic conditions affect the probability of divorce, and how demographic characteristics of families affect divorce and are mitigated or accentuated by macroeconomic conditions. ..
  21. SPRY2 predicts survival post-chemotherapy in advanced ovarian cancer.
    Raymond P Perez; Fiscal Year: 2010
    ..By refining prediction of outcomes post-chemotherapy, the proposed studies could therefore potentially translate into significant improvements in public health. ..
  22. miRNA and colorectal cancer: associations with tumor phenotype and survival
    Martha L Slattery; Fiscal Year: 2013
    ..using recent extensions of several statistical methods including ANOVA, logistic regression, and Cox proportional hazards models. Our sample size allows for both a training and validation component, and provides sufficient ..
  23. MEASUREMENT ERRORS IN CANCER EPIDEMIOLOGY
    DONNA L SPIEGELMAN; Fiscal Year: 2013
    ....
  24. Determining Processes of Cardiovascular Care Relevant to Complex Patients
    Elizabeth A Bayliss; Fiscal Year: 2010
    ..More importantly, findings will provide complex patients and their clinicians with additional information to inform personalized decisions across a spectrum of care. ..
  25. Sexual Behavior Trajectories from Adolescence to Adulthood
    Carolyn T Halpern; Fiscal Year: 2013
    ..abstract_text> ..
  26. PROMOTING RESEARCH CAREERS AMONG UNDERREPRESENTED MINORITY PHYSICIANS
    Donna B Jeffe; Fiscal Year: 2013
    ....
  27. TLR-mediated gender differences in HIV-1 pathogenesis
    Marcus Altfeld; Fiscal Year: 2013
    ..The results from these studies will guide future translation studies in humans, and might provide rational to use TLR antagonists to reduce HIV-1-induced immune activation and consecutive pathology. ..
  28. Risk and Risk Preferences for Surgery and Medical Therapy in Ulcerative Colitis
    Meenakshi Bewtra; Fiscal Year: 2013
    ..Cox proportional hazards models with adjustment will be used to detemnine relative survival of UC patients treated with medical and ..
  29. Anticholinergics and Cognitive Decline in the Elderly with Depression
    Rajender R Aparasu; Fiscal Year: 2013
    ....
  30. Comparative Risk of Endometrial Cancer from Ablation Versus Medical Management
    BRIAN LESLIE STROM; Fiscal Year: 2012
    ..This will help women make informed decisions regarding their treatment options for abnormal menstrual bleeding, and help physicians make proper guidelines and recommendations for cancer monitoring and treatment. ..
  31. Stimulants and Vascular Events in ADHD
    Mark Olfson; Fiscal Year: 2010
    ..We will use Cox proportional hazards models and case crossover analyses with time dependent measures of stimulant treatment to assess these ..
  32. Investigation of Longitudinal Consequences of Adverse Events among Older Adults
    Mary W Carter; Fiscal Year: 2010
    ..The study addresses the Institute of Medicine's To Err is Human objective to reduce medical injuries as well as the Healthy People 2010's objectives to improve patient safety and reduce injuries. ..
  33. Determinants of Venous Thromboembolism in Older People
    Robert J Glynn; Fiscal Year: 2010
    ..include Kaplan-Meier estimates of cumulative risk and estimates of the relative hazard of VTE based on proportional hazards models. Strengths of the studies include their prospective design, high follow-up rates, detailed and reliable,..
  34. An Innovative Model to Predict Readmissions in Adults with Cardiovascular Disease
    MATTHEW DUPRE; Fiscal Year: 2013
    ....
  35. Alcohol and Coronary Heart Disease in People with HIV
    Matthew S Freiberg; Fiscal Year: 2010
    ..Aim#3 will prospectively evaluate the association between alcohol and CHD mortality using proportional hazards models. Aims #1 &2 will be addressed by studying the HIV LIVE (Longitudinal Interrelationships of Viruses ..
  36. Mother's Education After Childbearing and Family Well-being
    Jennifer March Augustine; Fiscal Year: 2013
    ....
  37. Estimates of Influenza Vaccine Effectiveness
    Peter G Szilagyi; Fiscal Year: 2010
    ....
  38. Mortality and Macroeconomic Conditions: Differential Vulnerability and Mechanism
    JOSE A TAPIA GRANADOS; Fiscal Year: 2010
    ....
  39. Obesity susceptibility loci and breast cancer risk in BRCA1 and BRCA2 mutation ca
    JONATHAN ANDREW MITCHELL; Fiscal Year: 2013
    ..The research proposed has the potential to identify an important modifier of breast cancer in BRCA1/2 carriers that can be target through energetic interventions that influence energy balance. ..
  40. Long-Term Outcomes of Nonmelanoma Skin Cancer
    Mary Margaret Chren; Fiscal Year: 2009
    ..Multivariate Cox proportional hazards models will also be used to explore the distribution of time to detection of first tumor recurrence...
  41. Diagnostic Innovations in Glaucoma: Structural Assessment
    Linda M Zangwill; Fiscal Year: 2013
    ..and relevant clinical and demographic predictive factors will be included in multivariable Cox proportional hazards models for predicting who will develop photograph based and/or visual field based progression and who will ..
  42. Where were you then? New insights into breast cancer and the environment (PQ2)
    Peggy Reynolds; Fiscal Year: 2013
    ....
  43. Informatic tools for predicting an ordinal response for high-dimensional data
    Kellie J Archer; Fiscal Year: 2013
    ..have been successfully applied to high-throughput genomic datasets in fitting linear, logistic, and Cox proportional hazards models with excellent performance...
  44. Evaluating Prediction Models for Cancer Endpoints Subject to Dependent Censoring
    Qi Long; Fiscal Year: 2013
    ....
  45. Semiparametric Regression Analysis of Censored Data
    Danyu Lin; Fiscal Year: 2013
    ..User-friendly, open-source software will developed and disseminated. This research will yield novel and powerful statistical and commputational tools that can be readily used by medical investigators. ..
  46. Community-Based Studies in Cancer and Environment
    Yi Li; Fiscal Year: 2011
    ..abstract_text> ..
  47. INFECTION, IMMUNIZATION AND HOST POPULATION DYNAMICS
    A John; Fiscal Year: 1993
    ....
  48. Gender Differences in Access to Publicly-Funded Substance Abuse Services
    CHRISTINA MARIE ANDREWS; Fiscal Year: 2012
    ..The proposed study will identify specific factors at the levels of policy and practice that can be reworked to decrease wait times and consequently improve rates of substance abuse treatment access in the public system. ..
  49. Fertility After a Large-Scale Disaster
    JENNA E NOBLES; Fiscal Year: 2013
    ..Of particular importance is our ability to assess why fertility changes in the context of disaster - an underdeveloped line of inquiry with clear implications for improving recovery policy and interpreting modern fertility trends. ..
  50. Race and Long-Term Diabetes Self-Management in an HMO
    Dennis Ross Degnan; Fiscal Year: 2004
    ..oral therapy), we will use descriptive analyses, generalized linear mixed models, and proportional hazards models to (1) identify racial differences in self-management practices and diabetes-related health outcomes ..
  51. Statistical Methods for Correlated and High-Dimensional Biomedical Data
    Xihong Lin; Fiscal Year: 2013
    ..In collaboration with biomedical investigators, we will apply the proposed models and methods to several motivating data sets on cancer research and other fields of research. ..
  52. Referrals for Dental Care from a Medical Office-Based Preventive Dental Program
    SALLY STEARNS; Fiscal Year: 2007
    ..Findings from this study will contribute to the evidence for physicians' role in improving access to dental care and oral health status for underserved, low-income children. [unreadable] [unreadable] [unreadable]..
  53. ECHOCARDIOGRAPHIC STROKE PREDICTORS IN A TRI-ETHNIC COMM
    Marco Di Tullio; Fiscal Year: 2003
    ..This study will be the first prospective cohort study to evaluate the role of multiple echocardiographic risk factors for ischemic stroke in a community of whites, blacks and Hispanics living in the same area. ..
  54. Hormone markers during pregnancy and ovarian concer risk
    Sven Cnattingius; Fiscal Year: 2005
    ..We estimate to include at least 1,000 women with ovarian cancer. We will use Cox proportional hazards models and Poisson regression models to estimate ovarian cancer incidence rate ratios for exposures of ..
  55. Pharmacogenetics: Breast Cancer Treatment and Prognosis
    Christine Ambrosone; Fiscal Year: 2005
    ..Kaplan-Meier survival function, log rank tests for survival differences and Cox proportional hazards models will be used to determine the impact of genetic variability on disease-free survival, adjusting for ..
  56. Neighborhood SES and Emotional Distress in Old Age
    CAROL ANESHENSEL; Fiscal Year: 2009
    ..We hypothesize that the most negative health effects of living in areas of socioeconomic disadvantage will be among those who consistently live in such areas over time, and those who live in areas that deteriorate over time. ..
  57. Alcohol and intentional injury in the U.S Army
    Nicole Bell; Fiscal Year: 2004
    ..Standard time-to-event statistical techniques will be employed (e.g., Cox Proportional Hazards Models). MIMIC models (i.e...
  58. Fertility Decision-Making and Reproductive Health Outcomes in the Era of Antiretr
    SHEREE SCHWARTZ; Fiscal Year: 2009
    ..Cox proportional hazards models will compare pregnancy risk between the two treatment groups, controlling for time-varying CD4 count ..
  59. DEVELOPMENT AND VALIDATION OF A HEAD AND NECK CANCER COM
    Jay Piccirillo; Fiscal Year: 2000
    ..The predictive ability of the two indices will be tested using logistic regression and Cox Proportional Hazards models. The indices will be compared on the basis of the performance of the regression models and c-statistic...
  60. HIGH RISK COHORTS IN KENYA; PROSTITUTES AND TRUCKDRIVERS
    Joan Kreiss; Fiscal Year: 1993
    ..Kaplan Meier survival analysis and Cox proportional hazards models will be used to determine HIV seroincidence and correlates for seroconversion in each of the cohorts...
  61. Locus of Care & Pressure Ulcers After Hip Fracture
    Mona Baumgarten; Fiscal Year: 2004
    ..Discrete time proportional hazards models will be used to identify risk factors that are associated with increased pressure ulcer rates and to ..
  62. Risks for Opioid Use and Abuse in Contrasting Chronic Pain Populations
    Mark Sullivan; Fiscal Year: 2009
    ..with new treatment episodes for these chronic pain conditions, and follow them over time, using Cox proportional hazards models to assess predictors of chronic opioid initiation...
  63. TIME-DEPENDENT EFFECT OF ALCOHOL ON SPONTANEOUS ABORTION
    Gayle Windham; Fiscal Year: 1993
    ..The analysis will use proportional hazards models to calculate the risk of SAB by gestational age, with alcohol consumption during a specified time ..
  64. Natriuretic Peptides, Genes, and Diastolic Heart Failure
    Thomas Wang; Fiscal Year: 2007
    ..variation in natriuretic peptides and natriuretic peptide levels with incident heart failure, using proportional hazards models; (3) to assess the effects of exogenous B-type natriuretic peptide on myocardial function in patients ..
  65. Psychological and Financial Burden of Cancer Caregiving in Elderly Spouses
    Nicholas Christakis; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..