linear models

Summary

Summary: Statistical models in which the value of a parameter for a given value of a factor is assumed to be equal to a + bx, where a and b are constants. The models predict a linear regression.

Top Publications

  1. pmc Hierarchical generalized linear models for multiple groups of rare and common variants: jointly estimating group and individual-variant effects
    Nengjun Yi
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA
    PLoS Genet 7:e1002382. 2011
  2. ncbi Neural basis of a perceptual decision in the parietal cortex (area LIP) of the rhesus monkey
    M N Shadlen
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, and Regional Primate Research Center, University of Washington, Seattle, Washington 98195 7290, USA
    J Neurophysiol 86:1916-36. 2001
  3. ncbi Associations between objectively assessed physical activity and indicators of body fatness in 9- to 10-y-old European children: a population-based study from 4 distinct regions in Europe (the European Youth Heart Study)
    Ulf Ekelund
    MRC Epidemiology Unit, Strangeways Research Laboratories, Wort s Causeway, Cambridge CB1 8RN, United Kingdom
    Am J Clin Nutr 80:584-90. 2004
  4. pmc Baseline serum 25-hydroxy vitamin d is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990-2000
    Nita G Forouhi
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Diabetes 57:2619-25. 2008
  5. ncbi Development of a brief test to measure functional health literacy
    D W Baker
    Department of Medicine, Department of Epidemiology and Biostatistics, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH 44109 1998, USA
    Patient Educ Couns 38:33-42. 1999
  6. pmc Concentrations of urinary phthalate metabolites are associated with increased waist circumference and insulin resistance in adult U.S. males
    Richard W Stahlhut
    Department of Community and Preventive Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Environ Health Perspect 115:876-82. 2007
  7. ncbi Human myocardium: single-breath-hold MR T1 mapping with high spatial resolution--reproducibility study
    Daniel R Messroghli
    BHF Cardiac MRI Unit, Leeds General Infirmary, England
    Radiology 238:1004-12. 2006
  8. ncbi The Anti Cancer Council of Victoria FFQ: relative validity of nutrient intakes compared with weighed food records in young to middle-aged women in a study of iron supplementation
    A Hodge
    Cancer Epidemiology Centre, Anti Cancer Council of Victoria, 1 Rathdowne Street, Carlton, Victoria 3053
    Aust N Z J Public Health 24:576-83. 2000
  9. ncbi Regression models for twin studies: a critical review
    John B Carlin
    Clinical Epidemiology and Biostatistics Unit, Murdoch Children s Research Institute, Royal Children s Hospital, Melbourne, Australia
    Int J Epidemiol 34:1089-99. 2005
  10. pmc Rice consumption contributes to arsenic exposure in US women
    Diane Gilbert-Diamond
    Children s Environmental Health and Disease Prevention Center at Dartmouth, Hanover, NH 03755, USA
    Proc Natl Acad Sci U S A 108:20656-60. 2011

Detail Information

Publications369 found, 100 shown here

  1. pmc Hierarchical generalized linear models for multiple groups of rare and common variants: jointly estimating group and individual-variant effects
    Nengjun Yi
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA
    PLoS Genet 7:e1002382. 2011
    ..The proposed hierarchical generalized linear models introduce a group effect and a genetic score (i.e...
  2. ncbi Neural basis of a perceptual decision in the parietal cortex (area LIP) of the rhesus monkey
    M N Shadlen
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, and Regional Primate Research Center, University of Washington, Seattle, Washington 98195 7290, USA
    J Neurophysiol 86:1916-36. 2001
    ..The time course of the neural response suggests that LIP accumulates sensory signals relevant to the selection of a target for an eye movement...
  3. ncbi Associations between objectively assessed physical activity and indicators of body fatness in 9- to 10-y-old European children: a population-based study from 4 distinct regions in Europe (the European Youth Heart Study)
    Ulf Ekelund
    MRC Epidemiology Unit, Strangeways Research Laboratories, Wort s Causeway, Cambridge CB1 8RN, United Kingdom
    Am J Clin Nutr 80:584-90. 2004
    ..The rising prevalence of obesity in children may be due to a reduction in physical activity (PA)...
  4. pmc Baseline serum 25-hydroxy vitamin d is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990-2000
    Nita G Forouhi
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Diabetes 57:2619-25. 2008
    ..However, prospective data using the biomarker serum 25-hydroxyvitamin D [25(OH)D] are limited and therefore examined in the present study...
  5. ncbi Development of a brief test to measure functional health literacy
    D W Baker
    Department of Medicine, Department of Epidemiology and Biostatistics, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH 44109 1998, USA
    Patient Educ Couns 38:33-42. 1999
    ..The S-TOFHLA is a practical measure of functional health literacy with good reliability and validity that can be used by health educators to identify individuals who require special assistance to achieve learning goals...
  6. pmc Concentrations of urinary phthalate metabolites are associated with increased waist circumference and insulin resistance in adult U.S. males
    Richard W Stahlhut
    Department of Community and Preventive Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Environ Health Perspect 115:876-82. 2007
    ..Low testosterone in adult human males has been associated with increased prevalence of obesity, insulin resistance, and diabetes...
  7. ncbi Human myocardium: single-breath-hold MR T1 mapping with high spatial resolution--reproducibility study
    Daniel R Messroghli
    BHF Cardiac MRI Unit, Leeds General Infirmary, England
    Radiology 238:1004-12. 2006
    ..This technique could enable direct quantification of changes in tissue characteristics in ischemic and inflammatory myocardial diseases...
  8. ncbi The Anti Cancer Council of Victoria FFQ: relative validity of nutrient intakes compared with weighed food records in young to middle-aged women in a study of iron supplementation
    A Hodge
    Cancer Epidemiology Centre, Anti Cancer Council of Victoria, 1 Rathdowne Street, Carlton, Victoria 3053
    Aust N Z J Public Health 24:576-83. 2000
    ..To assess the validity of the Anti Cancer Council of Victoria food frequency questionnaire (ACCVFFQ) relative to seven-day weighed food records (WFRs) in 63 women of child-bearing age...
  9. ncbi Regression models for twin studies: a critical review
    John B Carlin
    Clinical Epidemiology and Biostatistics Unit, Murdoch Children s Research Institute, Royal Children s Hospital, Melbourne, Australia
    Int J Epidemiol 34:1089-99. 2005
    ..We recommend the use of a general model that includes separate regression coefficients for within-twin-pair and between-pair effects, and provide guidelines for the interpretation of estimates obtained under this model...
  10. pmc Rice consumption contributes to arsenic exposure in US women
    Diane Gilbert-Diamond
    Children s Environmental Health and Disease Prevention Center at Dartmouth, Hanover, NH 03755, USA
    Proc Natl Acad Sci U S A 108:20656-60. 2011
    ..3 g/d, which is ∼0.5 cup of cooked rice each day. In general linear models adjusted for age and urinary dilution, both rice consumption (g, dry mass/d) and arsenic exposure through ..
  11. pmc Correction for hidden confounders in the genetic analysis of gene expression
    Jennifer Listgarten
    Microsoft Research, 1100 Glendon Avenue, Suite PH1, Los Angeles, CA, USA
    Proc Natl Acad Sci U S A 107:16465-70. 2010
    ..Lastly, our software and the associations we found with it are available at http://www.microsoft.com/science...
  12. pmc Mathematics of quantitative kinetic PCR and the application of standard curves
    R G Rutledge
    Natural Resources Canada, Canadian Forest Service, Laurentian Forestry Centre, 1055 du P E P S, PO Box 3800, Sainte Foy, Quebec G1V 4C7, Canada
    Nucleic Acids Res 31:e93. 2003
    ..A simplified method for absolute quantification is also proposed, in which quantitative scale is determined by DNA mass at threshold...
  13. ncbi Multiple regression of cost data: use of generalised linear models
    Julie Barber
    Research and Development Directorate, University College London Hospitals R and D Directorate, 1st Floor, Maple House, 149 Tottenham Court Road, London, W1P 9LL, UK
    J Health Serv Res Policy 9:197-204. 2004
    ..In this paper we illustrate the use of generalised linear models for regression analysis of cost data.
  14. ncbi Spike-triggered neural characterization
    Odelia Schwartz
    Howard Hughes Medical Institute and The Salk Intitute, La Jolla, CA 92037, USA
    J Vis 6:484-507. 2006
    ..We describe this methodology, demonstrating it with simulated model neuron examples that emphasize practical issues that arise in experimental situations...
  15. ncbi Genetic and environmental influences on birth weight, birth length, head circumference, and gestational age by use of population-based parent-offspring data
    Astrid Lunde
    Section for Epidemiology and Medical Statistics, Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway
    Am J Epidemiol 165:734-41. 2007
    ..Relative to the proportion of explained variation, fetal genes were most important for birth length and head circumference...
  16. pmc Myocardial T1 and extracellular volume fraction mapping at 3 tesla
    Jason J Lee
    Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, MD, USA
    J Cardiovasc Magn Reson 13:75. 2011
    ..To compare 11 heartbeat (HB) and 17 HB modified lock locker inversion recovery (MOLLI) pulse sequence at 3T and to establish preliminary reference values for myocardial T1 and the extracellular volume fraction (ECV)...
  17. ncbi The use of fractional polynomials to model continuous risk variables in epidemiology
    P Royston
    Department of Medical Statistics and Evaluation, Imperial College School of Medicine, London, UK
    Int J Epidemiol 28:964-74. 1999
    The traditional method of analysing continuous or ordinal risk factors by categorization or linear models may be improved.
  18. ncbi Global and gene-specific promoter methylation changes are related to anti-B[a]PDE-DNA adduct levels and influence micronuclei levels in polycyclic aromatic hydrocarbon-exposed individuals
    Sofia Pavanello
    Occupational Health Section, Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy
    Int J Cancer 125:1692-7. 2009
    ..We also evaluated whether PAH-induced DNA methylation states were in turn associated with micronuclei in PBLs, an indicator of chromosomal instability...
  19. pmc Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth
    Cathy E Elks
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge, United Kingdom
    PLoS Med 7:e1000284. 2010
    ..Exploration of these genotype associations in children may provide insights into the timing of weight changes leading to adult obesity...
  20. ncbi The effects of body mass index on lung volumes
    Richard L Jones
    Pulmonary Division, University of Alberta, Edmonton, AB, Canada T6G 2B7
    Chest 130:827-33. 2006
    ..It is well known that obesity causes decreases in lung volumes, but there has never been a large study showing the correlation between body mass index (BMI) and the various lung volumes...
  21. ncbi Longitudinal study of moderate weight change and sleep-disordered breathing
    P E Peppard
    University of Wisconsin School of Medicine, Department of Preventive Medicine, 502 N Walnut St, Madison, WI 53705, USA
    JAMA 284:3015-21. 2000
    ..Excess body weight is positively associated with sleep-disordered breathing (SDB), a prevalent condition in the US general population. No large study has been conducted of the longitudinal association between SDB and change in weight...
  22. pmc Hierarchical generalized linear models for multiple quantitative trait locus mapping
    Nengjun Yi
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama, Birmingham, Alabama 35294 0022, USA
    Genetics 181:1101-13. 2009
    We develop hierarchical generalized linear models and computationally efficient algorithms for genomewide analysis of quantitative trait loci (QTL) for various types of phenotypes in experimental crosses...
  23. ncbi Risk-sensitive neurons in macaque posterior cingulate cortex
    Allison N McCoy
    Department of Neurobiology, Duke University Medical Center, Box 3209, Durham, North Carolina 27710, USA
    Nat Neurosci 8:1220-7. 2005
    ..CGp activation was better predicted by the subjective salience of a chosen target than by its actual value. These data suggest that CGp signals the subjective preferences that guide visual orienting...
  24. ncbi The effect of age on pain, function, and quality of life after total hip and knee arthroplasty
    C A Jones
    Department of Public Health Sciences, PT, Room 2137, Dentistry Pharmacy Bldg, University of Alberta, Edmonton, Alberta, Canada T6G 2N8
    Arch Intern Med 161:454-60. 2001
    ....
  25. ncbi Association of black carbon with cognition among children in a prospective birth cohort study
    S Franco Suglia
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
    Am J Epidemiol 167:280-6. 2008
    ..9, 95% CI: -7.5, -0.3) of the Wide Range Assessment of Memory and Learning. Higher levels of black carbon predicted decreased cognitive function across assessments of verbal and nonverbal intelligence and memory constructs...
  26. ncbi You are where you shop: grocery store locations, weight, and neighborhoods
    Sanae Inagami
    Veterans Affairs Health Services and Research Development, VA Greater Los Angeles Health Care System, Division of General Internal Medicine, Los Angeles, California 90073, USA
    Am J Prev Med 31:10-7. 2006
    ..One possible reason might be the quality of available foods in their area. Location of grocery stores where individuals shop and its association with BMI were examined...
  27. ncbi Serum 1,25-dihydroxy vitamin D is inversely associated with body mass index
    Steinar Konradsen
    Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway
    Eur J Nutr 47:87-91. 2008
    ....
  28. pmc Personal factors associated with health-related quality of life in persons with morbid obesity on treatment waiting lists in Norway
    Anners Lerdal
    Division of Medicine, Section of Gastroenterology, Oslo University Hospital, Aker, Trondheimsveien 235, 0514, Oslo, Norway
    Qual Life Res 20:1187-96. 2011
    ....
  29. ncbi Extending the simple linear regression model to account for correlated responses: an introduction to generalized estimating equations and multi-level mixed modelling
    P Burton
    Division of Biostatistics and Genetic Epidemiology, TVW Telethon Institute for Child Health Research, West Perth, WA, Australia
    Stat Med 17:1261-91. 1998
    ....
  30. pmc Microarray analysis after RNA amplification can detect pronounced differences in gene expression using limma
    Ilhem Diboun
    Bioinformatics Unit, Department of Biochemistry and Molecular Biology, University College London, Gower Street, London, WC1E 6BT, UK
    BMC Genomics 7:252. 2006
    ..However, the consequences of such distortions on the ability to detect biological variation in expression have not been explored sufficiently to define the true extent of usability and limitations of such amplification techniques...
  31. ncbi Dimensionality reduction in neural models: an information-theoretic generalization of spike-triggered average and covariance analysis
    Jonathan W Pillow
    Gatsby Computational Neuroscience Unit, University College London, London, UK
    J Vis 6:414-28. 2006
    ..We demonstrate the effectiveness of the method by applying it to simulated responses of a Hodgkin-Huxley neuron and the recorded extracellular responses of macaque retinal ganglion cells and V1 cells...
  32. ncbi Classical and Bayesian inference in neuroimaging: theory
    K J Friston
    The Wellcome Department of Imaging Neuroscience, The Gatsby Computational Neuroscience Unit, University College London, Queen Square, London, WC1N 3BG, United Kingdom
    Neuroimage 16:465-83. 2002
    ..In particular we formulate the procedures used in conventional data analysis in terms of hierarchical linear models and establish a connection between classical inference and parametric empirical Bayes (PEB) through covariance ..
  33. pmc Comparison of the Framingham Heart Study hypertension model with blood pressure alone in the prediction of risk of hypertension: the Multi-Ethnic Study of Atherosclerosis
    Paul Muntner
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Hypertension 55:1339-45. 2010
    ..001); recalibrated and best-fit models produced a better model fit (P=0.064 and 0.245, respectively). In this multiethnic cohort of US adults, the FHS model was not substantially better than SBP alone for predicting hypertension...
  34. ncbi Blood pressure and not uraemia is the major determinant of arterial stiffness and endothelial dysfunction in patients with chronic kidney disease and minimal co-morbidity
    Pajaree Lilitkarntakul
    Clinical Pharmacology Unit, British Heart Foundation, Centre of Research Excellence, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Atherosclerosis 216:217-25. 2011
    ....
  35. pmc Increased arterial stiffness in healthy subjects with high-normal glucose levels and in subjects with pre-diabetes
    Jin Young Shin
    Department of Family Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
    Cardiovasc Diabetol 10:30. 2011
    ..The purpose of this study is to investigate the relationship between FPG and arterial stiffness in non-diabetic healthy subjects...
  36. ncbi Linking objectively measured physical activity with objectively measured urban form: findings from SMARTRAQ
    Lawrence D Frank
    University of British Columbia, School of Community and Regional Planning, Vancouver, British Columbia, Canada
    Am J Prev Med 28:117-25. 2005
    ..To date, nearly all research on physical activity and the built environment is based on self-reported physical activity and perceived assessment of the built environment...
  37. ncbi Food store access and household fruit and vegetable use among participants in the US Food Stamp Program
    Donald Rose
    Department of Community Health Sciences, School of Public Health and Tropical Medicine, Tulane University, 1440 Canal Street, Suite 2301, New Orleans, LA 70112, USA
    Public Health Nutr 7:1081-8. 2004
    ..This study examined the relationship between various measures of food store access and household fruit and vegetable use among participants in the Food Stamp Program, America's largest domestic food assistance programme...
  38. ncbi The importance of the normality assumption in large public health data sets
    Thomas Lumley
    Department of Biostatistics, University of Washington, Box 357232, Seattle, Washington 98195, USA
    Annu Rev Public Health 23:151-69. 2002
    ..The major limitation on the t-test and linear regression for inference about associations is not a distributional one, but whether detecting and estimating a difference in the mean of the outcome answers the scientific question at hand...
  39. ncbi Modelling covariance structure in the analysis of repeated measures data
    R C Littell
    Department of Statistics, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, Florida 32611, USA
    Stat Med 19:1793-819. 2000
    ..In many situations, estimates of linear combinations are invariant with respect to covariance structure, yet standard errors of the estimates may still depend on the covariance structure...
  40. ncbi Discrete coding of reward probability and uncertainty by dopamine neurons
    Christopher D Fiorillo
    Institute of Physiology, University of Fribourg, CH 1700 Fribourg, Switzerland
    Science 299:1898-902. 2003
    ..The coding of uncertainty suggests a possible role for dopamine signals in attention-based learning and risk-taking behavior...
  41. pmc Fast evaluation of fluctuations in biochemical networks with the linear noise approximation
    Johan Elf
    Department of Cell and Molecular Biology, Uppsala University, BMC, 751 24 Uppsala, Sweden
    Genome Res 13:2475-84. 2003
    ..We describe how the LNA can give precise system descriptions also near macroscopic instabilities by suitable variable changes and elimination of fast variables...
  42. pmc Does more accurate exposure prediction necessarily improve health effect estimates?
    Adam A Szpiro
    Department of Biostatistics, University of Washington, Seattle, WA 98195, USA
    Epidemiology 22:680-5. 2011
    ..We interpret our results in light of recently developed statistical theory for measurement error, and we discuss implications for the design and analysis of epidemiologic research...
  43. ncbi A parent-focused intervention to reduce infant obesity risk behaviors: a randomized trial
    Karen J Campbell
    Centre for Physical Activity and Nutrition Research, Deakin University, 221 Burwood Highway, Burwood 3125, Australia
    Pediatrics 131:652-60. 2013
    ..To assess the effectiveness of a parent-focused intervention on infants' obesity-risk behaviors and BMI...
  44. ncbi Contrast's effect on spatial summation by macaque V1 neurons
    M P Sceniak
    Center for Neural Science, New York University, 4 Washington Pl, New York, New York 10003, USA
    Nat Neurosci 2:733-9. 1999
    ..3-fold greater at low contrast. This adaptive increase in spatial summation at low contrast was seen in cells throughout V1 and was independent of surround inhibition...
  45. ncbi Normalized left ventricular systolic and diastolic function by steady state free precession cardiovascular magnetic resonance
    A M Maceira
    Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, London, UK
    J Cardiovasc Magn Reson 8:417-26. 2006
    ..These novel data have particular importance for clinical practice and clinical trials using CMR...
  46. ncbi Genetic network inference: from co-expression clustering to reverse engineering
    P D'haeseleer
    University of New Mexico, Department of Computer Science, Albuquerque, NM 87131, USA
    Bioinformatics 16:707-26. 2000
    ..of reverse engineering of genetic networks, from discrete Boolean networks, to continuous linear and non-linear models. We conclude that the combination of predictive modeling with systematic experimental verification will be ..
  47. ncbi Type 2 diabetes is associated with impaired endothelium-dependent, flow-mediated dilation, but impaired glucose metabolism is not; The Hoorn Study
    Ronald M A Henry
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Atherosclerosis 174:49-56. 2004
    ..It is controversial whether or not FMD is impaired in DM2 and IGM. We investigated this issue in a population-based setting...
  48. ncbi Insulin-like growth factor-I, IGF-binding protein-3, and mammographic breast density
    Caroline Diorio
    Unité de recherche en santé des populations, Centre Hospitalier Affilie Universitaire De Quebec, Hôpital Saint Sacrement, 1050 Chemin Sainte Foy, Quebec, Quebec, Canada G1S 4L8
    Cancer Epidemiol Biomarkers Prev 14:1065-73. 2005
    ..Adjusted mean breast density was assessed by joint levels of IGF-I and IGFBP-3 using generalized linear models. Among premenopausal women, high levels of IGF-I and low levels of IGFBP-3 were independently correlated with ..
  49. ncbi Body composition analysis by leg-to-leg bioelectrical impedance and dual-energy X-ray absorptiometry in non-obese and obese individuals
    Z Boneva-Asiova
    Endocrinology Unit, Central Police Hospital, Sofia, Bulgaria
    Diabetes Obes Metab 10:1012-8. 2008
    ..The aim of this study is to compare total weight, % body fat (% BF), fat mass (FM) and fat-free mass (FFM) measured by bioelectrical impedance analysis (BIA) and dual-energy X-ray absorptiometry (DXA)...
  50. pmc Genetic heterogeneity of residual variance - estimation of variance components using double hierarchical generalized linear models
    Lars Rönnegård
    Statistics Unit, Dalarna University, SE 781 70 Borlänge, Sweden
    Genet Sel Evol 42:8. 2010
    ..Here, linear mixed models with genetic effects in the residual variance part of the model can be used. Such models have previously been fitted using EM and MCMC algorithms...
  51. ncbi Similar associations of parental prenatal smoking suggest child blood pressure is not influenced by intrauterine effects
    Marie Jo A Brion
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, United Kingdom
    Hypertension 49:1422-8. 2007
    ..36 to 0.87; P=0.4 fully adjusted), providing further evidence that differences in child blood pressure observed in minimally adjusted models are not because of a biological influence of maternal smoking on the intrauterine environment...
  52. ncbi Assessment of Poisson, logit, and linear models for genetic analysis of clinical mastitis in Norwegian Red cows
    A I Vazquez
    Department of Dairy Science, University of Wisconsin, Madison 53706, USA
    J Dairy Sci 92:739-48. 2009
    ..6 and 3.5 for Poisson and linear, respectively, and for model for CM was 3.7 in both logit and linear models. The MSEP for all cows was similar. However, within healthy animals, MSEP was 0.085 (Poisson), 0...
  53. ncbi Faster cyclic loess: normalizing RNA arrays via linear models
    Karla V Ballman
    Division of Biostatistics, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Bioinformatics 20:2778-86. 2004
    ..Our goal was to develop a normalization technique that yields results similar to cyclic loess normalization and with speed comparable to quantile normalization...
  54. pmc Expression levels of uridine 5'-diphospho-glucuronosyltransferase genes in breast tissue from healthy women are associated with mammographic density
    Vilde D Haakensen
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Montebello, NO 0310, Norway
    Breast Cancer Res 12:R65. 2010
    ..However, the biologic correlates of density are little known...
  55. pmc Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio
    Aluisio J D Barros
    Programa de Pós Graduação em Epidemiologia, Universidade Federal de Pelotas, Brazil
    BMC Med Res Methodol 3:21. 2003
    ..Also, controlling for confounding is not equivalent for the two measures. In this paper we explore alternatives for modeling data of such studies with techniques that directly estimate the prevalence ratio...
  56. pmc Association between lung function and exacerbation frequency in patients with COPD
    Martine Hoogendoorn
    Institute for Medical Technology Assessment, Erasmus University, Rotterdam
    Int J Chron Obstruct Pulmon Dis 5:435-44. 2010
    ..To quantify the relationship between severity of chronic obstructive pulmonary disease (COPD) as expressed by Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage and the annual exacerbation frequency in patients with COPD...
  57. ncbi Low levels of androgens in men with erectile dysfunction and obesity
    Giovanni Corona
    Department of Clinical Physiopathology, Andrology Unit, University of Florence, Florence, Italy
    J Sex Med 5:2454-63. 2008
    ..The relationship between obesity and erectile dysfunction (ED) has not been completely clarified...
  58. pmc Stochastic optimal control and estimation methods adapted to the noise characteristics of the sensorimotor system
    Emanuel Todorov
    Department of Cognitive Science, University of California San Diego, La Jolla CA 92093 0515, USA
    Neural Comput 17:1084-108. 2005
    ..The application of the algorithm is illustrated in the context of reaching movements. A Matlab implementation is available at www.cogsci.ucsd.edu/~todorov...
  59. ncbi Effects of diurnal temperature range on cardiovascular and respiratory hospital admissions in Korea
    Youn Hee Lim
    Department of Epidemiology and Biostatistics, School of Public Health, Seoul National University, Seoul, South Korea
    Sci Total Environ 417:55-60. 2012
    ..These results support the hypothesis of a positive association between DTR and cardiovascular and respiratory hospital admission...
  60. ncbi Serum 25-hydroxyvitamin D is not associated with insulin resistance or beta cell function in Canadian Cree
    Liana C Del Gobbo
    McGill University, Center for Indigenous Peoples Nutrition and Environment, School of Dietetics and Human Nutrition, Ste Anne de Bellevue, Canada
    J Nutr 141:290-5. 2011
    ..Future longitudinal studies investigating the interrelationship among 25(OH)D, adiposity, and the risk of developing metabolic syndrome and type 2 diabetes are warranted...
  61. ncbi Morphological and functional vascular changes induced by childhood obesity
    Marco Matteo Ciccone
    Section of Cardiology, D E T O, University of Bari, Bari, Italy
    Eur J Cardiovasc Prev Rehabil 18:831-5. 2011
    ..To investigate endothelial dysfunction and morphological vascular changes in childhood obesity...
  62. ncbi A generalized linear-quadratic model incorporating reciprocal time pattern of radiation damage repair
    Zhibin Huang
    Department of Radiation Oncology, East Carolina University, Greenville, North Carolina 27834, USA
    Med Phys 39:224-30. 2012
    ..As a result, the purpose of this study was to investigate a new generalized linear-quadratic (LQ) model incorporating a repair pattern with reciprocal time. The new formulas were tested with published experimental data...
  63. ncbi Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides
    Jaspal S Kooner
    National Heart and Lung Institute, Imperial College London, UK
    Nat Genet 40:149-51. 2008
    ..4 x 10(-10)). MLXIPL coordinates transcriptional regulation of enzymes that channel glycolytic end-products into lipogenesis and energy storage, making MLXIPL a plausible 'thrifty gene'...
  64. ncbi Analyzing brain networks with PCA and conditional Granger causality
    Zhenyu Zhou
    Key Laboratory of Child Development and Learning Science, Southeast University, Ministry of Education, Nanjing, People s Republic of China
    Hum Brain Mapp 30:2197-206. 2009
    ..Furthermore, the use of PCA components in conjunction with conditional GCM greatly reduces the computational cost relative to the use of individual voxel time series...
  65. ncbi Serum autoantibodies against human oxidized low-density lipoproteins are inversely associated with severity of coronary stenotic lesions calculated by Gensini score
    Jingjin Che
    Department of Cardiology, Tianjin Institute of Cardiology, 2nd Hospital of Tianjin Medical University, Tianjin, People s Republic of China
    Cardiol J 18:364-70. 2011
    ..This study aimed to investigate the association between serum anti-oxLDL titers and the severity and extent of coronary stenotic lesions...
  66. ncbi Costs attributable to healthcare-acquired infection in hospitalized adults and a comparison of economic methods
    Rebecca R Roberts
    Department of Emergency Medicine, John H Stroger Jr Hospital of Cook County, Chicago, IL 60612, USA
    Med Care 48:1026-35. 2010
    ..Our goals were to estimate the costs attributable to healthcare-acquired infection (HAI) and conduct a sensitivity analysis comparing analytic methods...
  67. pmc Relationships between lipid profiles and metabolic syndrome, insulin resistance and serum high molecular adiponectin in Japanese community-dwelling adults
    Ryuichi Kawamoto
    Department of Community Medicine, Ehime University Graduate School of Medicine, Ehime, Japan
    Lipids Health Dis 10:79. 2011
    ..There are few studies to demonstrate the associations between newly addressed lipid profiles and metabolic syndrome (MetS)-associated variables...
  68. ncbi Cardiovascular risk factors are differently associated with urinary albumin excretion in men and women
    Jacobien C Verhave
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, Groningen University Institute of Drug Exploration GUIDE, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    J Am Soc Nephrol 14:1330-5. 2003
    ..It is concluded that gender differences exist in the association between cardiovascular risk factors and UAE. This is consistent with a larger vascular susceptibility to these risk factors in men as compared with women...
  69. ncbi Are American children and adolescents of low socioeconomic status at increased risk of obesity? Changes in the association between overweight and family income between 1971 and 2002
    Youfa Wang
    Center for Human Nutrition, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    Am J Clin Nutr 84:707-16. 2006
    ..A good understanding of the association between obesity and socioeconomic status (SES) has many important public health and policies implications, particularly for the prevention and management of obesity...
  70. ncbi A simple approach to assess VT during a field walk test
    V Z Dourado
    Federal University of Sao Paulo, Department of Health Sciences, Santos, Brazil
    Int J Sports Med 31:698-703. 2010
    ..05; 95%CI: -0.30-0.20  L/min). Thus, the VT can be assessed during the ISWT using a simple heart monitor. The ISWT may be a useful tool to assess exercise capacity and prescribe walking programs...
  71. ncbi Relationship between serum adiponectin and leptin concentrations and body fat distribution
    Keun Gyu Park
    Department of Internal Medicine, Keimyung University School of Medicine, Dongsan Medical Center, 194 Dongsan dong, Jung Gu, Daegu 00 712, South Korea
    Diabetes Res Clin Pract 63:135-42. 2004
    ..498, P<0.0001) In conclusion, adiponectin and leptin concentrations, although associated with metabolic parameters, were more strongly influenced by VAT in the case of adiponectin, and by SAT in the case of leptin...
  72. pmc Alcohol effects on cognitive change in middle-aged and older adults
    Faika Zanjani
    Department of Gerontology, University of Kentucky, Lexington, KY, USA
    Aging Ment Health 17:12-23. 2013
    ..This study examines cognitive outcomes for alcohol drinking status over time, across cognitive ability and age groups...
  73. ncbi Can exposure to noise affect the 24 h blood pressure profile? Results from the HYENA study
    Alexandros S Haralabidis
    Department of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece
    J Epidemiol Community Health 65:535-41. 2011
    ..OBJECTIVE; To study the association between exposure to transportation noise and blood pressure (BP) reduction during nighttime sleep...
  74. ncbi The development of numerical estimation: evidence for multiple representations of numerical quantity
    Robert S Siegler
    Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Psychol Sci 14:237-43. 2003
    ....
  75. pmc Health-related quality of life 'well-being' in HIV distal neuropathic pain is more strongly associated with depression severity than with pain intensity
    John R Keltner
    Department of Psychiatry, University of California San Diego, San Diego, CA 92117, USA
    Psychosomatics 53:380-6. 2012
    ..The relative contribution of depression and pain to worse life quality has not been addressed, however, even though a better understanding might sharpen intervention strategies...
  76. ncbi The loss of idealism throughout internship
    Charles H Griffith
    University of Kentucky, USA
    Eval Health Prof 26:415-26. 2003
    ..50%/48%, p < .0001). We conclude interns become less idealistic toward patients and the profession throughout internship, with the greatest change within the first 5 months...
  77. pmc Impact of ADMA, endothelial progenitor cells and traditional cardiovascular risk factors on pulse wave velocity among prediabetic individuals
    Ioannis Protopsaltis
    Diabetes Center, Tzanio General Hospital of Piraeus, Zanni and Afendouli 1, Piraeus 18537, Greece
    Cardiovasc Diabetol 11:141. 2012
    ..The correlations of novel and traditional cardiovascular risk factors with central arterial stiffness in prediabetic individuals were investigated in the present study...
  78. ncbi Vision related quality of life in multiple sclerosis: correlation with new measures of low and high contrast letter acuity
    E M Mowry
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Neurol Neurosurg Psychiatry 80:767-72. 2009
    ..To examine the relation between low contrast letter acuity, a new visual function test for multiple sclerosis (MS) trials, and vision targeted health related quality of life (HRQOL)...
  79. ncbi Association of perfluorooctanoic acid and perfluorooctane sulfonate with serum lipids among adults living near a chemical plant
    Kyle Steenland
    Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
    Am J Epidemiol 170:1268-78. 2009
    ..Because these data are cross-sectional, causal inference is limited. Nonetheless, the associations between these compounds and lipids raise concerns, given their common presence in the general population...
  80. pmc Reductions in arterial stiffness with weight loss in overweight and obese young adults: potential mechanisms
    Jennifer N Cooper
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Epidemiology Data Center, 130 DeSoto St, Pittsburgh, PA 15261, USA
    Atherosclerosis 223:485-90. 2012
    ..Arterial stiffness decreases with weight loss in overweight/obese young adults. We aimed to determine the mechanisms by which this occurs...
  81. ncbi The evaluation of the diet/disease relation in the EPIC study: considerations for the calibration and the disease models
    Pietro Ferrari
    International Agency for Research on Cancer IARC WHO, Lyon, France
    Int J Epidemiol 37:368-78. 2008
    ..This requires considerable work to standardize dietary measurements at the food and the nutrient levels...
  82. ncbi Dietary patterns and ethnicity are associated with distinct plasma proteomic groups
    Bibiana Garcia-Bailo
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Canada
    Am J Clin Nutr 95:352-61. 2012
    ..However, little is known about how concentrations of many plasma proteins vary between individuals from different ethnocultural groups with different dietary habits...
  83. ncbi The combination of EEG source imaging and EEG-correlated functional MRI to map epileptic networks
    Serge Vulliemoz
    Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, University College London, Queen Square, London, United Kingdom
    Epilepsia 51:491-505. 2010
    ..We then discuss analysis strategies to combine both techniques by reviewing studies in epilepsy, current methodologic development, and future directions of this fast-developing field...
  84. ncbi Premature cardiovascular events and mortality in south Asians with type 2 diabetes in the United Kingdom Asian Diabetes Study - effect of ethnicity on risk
    Srikanth Bellary
    Diabetes Centre, Heart of England NHS Foundation Trust, Birmingham, UK
    Curr Med Res Opin 26:1873-9. 2010
    ..We examined the effect of ethnicity on known risk factors and analysed the risk of cardiovascular events and mortality in UK south Asian and white Europeans patients with type 2 diabetes over a 2 year period...
  85. pmc Are neighborhood sociocultural factors influencing the spatial pattern of gonorrhea in North Carolina?
    Ashleigh B Sullivan
    Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
    Ann Epidemiol 21:245-52. 2011
    ..To determine if the spatial pattern of gonorrhea observed for North Carolina was influenced by neighborhood-level sociocultural determinants of health, including race/ethnicity...
  86. ncbi The association between acculturation and health practices among middle-aged and elderly Latinas
    P J Cantero
    Department of Preventive Medicine, University of Southern California, Los Angeles 90033 0800, USA
    Ethn Dis 9:166-80. 1999
    ..To examine the relationship between acculturation and five health practices, including cigarette smoking, alcohol consumption, exercise, obesity, and sleeping habits...
  87. ncbi Type 2 diabetes is associated with increased pulse wave velocity measured at different sites of the arterial system but not augmentation index in a Chinese population
    Minghua Zhang
    Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China
    Clin Cardiol 34:622-7. 2011
    ..Moreover, the association between pulse wave velocity (PWV) and augmentation index (AIx) in diabetes is poorly understood...
  88. ncbi Predictors of blood pressure response to the angiotensin receptor blocker candesartan in essential hypertension
    Vincent J Canzanello
    Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, USA
    Am J Hypertens 21:61-6. 2008
    ..Response to antihypertensive drugs varies widely among individuals...
  89. ncbi Fast global oscillations in networks of integrate-and-fire neurons with low firing rates
    N Brunel
    Ecole Normale Sup and eacuste rieure, LPS, 24 rue Lhomond, 75231 Paris, Cedex 5, France
    Neural Comput 11:1621-71. 1999
    ..Their characteristics are determined as functions of systems parameters in these two different regions. The results are found to be in good agreement with numerical simulations...
  90. ncbi Long-term effect of betaine on risk factors associated with the metabolic syndrome in healthy subjects
    U Schwab
    Department of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, Kuopio, Finland
    Eur J Clin Nutr 65:70-6. 2011
    ..To examine the effects of betaine on serum lipid profile, plasma homocysteine concentration and hemostatic factors in healthy subjects...
  91. ncbi Dietary fiber and subsequent changes in body weight and waist circumference in European men and women
    Huaidong Du
    National Institute for Public Health and the Environment RIVM, Bilthoven, Netherlands
    Am J Clin Nutr 91:329-36. 2010
    ..Dietary fiber may play a role in obesity prevention. Until now, the role that fiber from different sources plays in weight change had rarely been studied...
  92. pmc Prognostic significance of the complex "Visceral Adiposity Index" vs. simple anthropometric measures: Tehran lipid and glucose study
    Bozorgmanesh Mohammadreza
    Prevention of Metabolic Disorders Research Center, Research institute for endocrine sciences RIES, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    Cardiovasc Diabetol 11:20. 2012
    ..We compared the predictive abilities of the VAI with those of simple anthropometric measures i.e. BMI, waist-to-height ratio (WHtR) or waist-to-hip ratio (WHpR)...
  93. pmc Association of plasminogen activator inhibitor-1 and tissue plasminogen activator with type 2 diabetes and metabolic syndrome in Malaysian subjects
    Zaid Al-Hamodi
    Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Cardiovasc Diabetol 10:23. 2011
    ..The aim of this study was to investigate the association of tPA and its inhibitor PAI-1 with type 2 diabetes (T2D) and MetS and interrelationship between PAI-1 and tPA activities and antigens in Malaysian T2D and normal subjects...
  94. pmc Independent component analysis (ICA) of generalized spike wave discharges in fMRI: comparison with general linear model-based EEG-fMRI
    Friederike Moeller
    Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada
    Hum Brain Mapp 32:209-17. 2011
    ..This study demonstrated that the BOLD response largely resembles the standard HRF and that GLM analysis is adequate. However, ICA is more dependent on a sufficient number of events than GLM analysis...
  95. pmc Correlating changes in lung function with patient outcomes in chronic obstructive pulmonary disease: a pooled analysis
    Paul W Jones
    Division of Clinical Science, St George s, University of London, London, UK
    Respir Res 12:161. 2011
    ..We examined whether changes in trough forced expiratory volume in 1 second (FEV(1)) are correlated with changes in patient-reported outcomes...
  96. ncbi Environmental exposure to dioxins and polychlorinated biphenyls reduce levels of gonadal hormones in newborns: results from the Duisburg cohort study
    Yuguang Cao
    Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Int J Hyg Environ Health 211:30-9. 2008
    ..This study was done to evaluate effects related to the HPG axis...
  97. pmc The circulating inactive form of matrix gla protein is a surrogate marker for vascular calcification in chronic kidney disease: a preliminary report
    Leon J Schurgers
    INSERM ERI 12, Divisions of Clinical Pharmacology and Nephrology, Amiens University Hospital, Avenue Rene Laennec, F 80054 Amiens, France
    Clin J Am Soc Nephrol 5:568-75. 2010
    ....
  98. ncbi Linear relationship between systolic and diastolic blood pressure monitored over 24 h: assessment and correlates
    Benjamin Gavish
    InterCure Ltd, Lod, Israel
    J Hypertens 26:199-209. 2008
    ..We evaluated the effect of using symmetric regression on the AASI and its dependence on clinical characteristics using 24-h ambulatory monitoring...
  99. pmc Associations of seafood and elongated n-3 fatty acid intake with fetal growth and length of gestation: results from a US pregnancy cohort
    Emily Oken
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA
    Am J Epidemiol 160:774-83. 2004
    ..Results from this US cohort support the conclusion that seafood intake during pregnancy is associated with reduced fetal growth...
  100. ncbi Relationship between extent of pulmonary emphysema by high-resolution computed tomography and lung elastic recoil in patients with chronic obstructive pulmonary disease
    S Baldi
    Istituto di Fisiologia Clinica del CNR, Centro Regionale di Medicina Nucleare, Istituto di Radiologia, Dipartimento Cardio Toracico, Universita degli Studi di Pisa, Pisa, Italy
    Am J Respir Crit Care Med 164:585-9. 2001
    ..68, p < 0.0005). We conclude that currently used methods of assessing the extent of emphysema by HRCT closely reflect the reduction of CO diffusion constant, but cannot predict the elastic properties of the lung tissue...
  101. ncbi Psychosocial working conditions and depressive symptoms among Swedish employees
    Linda L Magnusson Hanson
    Work Organisation and Health, Stress Research Institute, Stockholm, Sweden
    Int Arch Occup Environ Health 82:951-60. 2009
    ..To investigate prospective associations between working conditions and depressive symptoms in Swedish men and women...

Research Grants79

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  2. Prenatal Cocaine Exposure: Young Adult Follow Up
    Ruth Rose-Jacobs; Fiscal Year: 2013
    ..We propose generalized mixed linear models to utilize fully the longitudinal nature of the data, including growth curve models to delineate trajectories, ..
  3. Feasibility and Preliminary Efficacy of Yoga in Head and Neck Cancer Survivors
    Sheila H Ridner; Fiscal Year: 2013
    ..Qualitative analysis, descriptive statistics, and Mixed Effects General Linear Models will be used to answer our aims...
  4. Personality and Health Services Use and Expenditures of Older Persons
    Bruce Friedman; Fiscal Year: 2010
    ..Two-part generalized linear models will be employed for expenditures...
  5. Meditation and Exercise for Prevention of Acute Respiratory Infection
    Bruce P Barrett; Fiscal Year: 2010
    ..Generalized estimating equations, random-effects pattern-mixture models, and hierarchical linear models will be used to assess longitudinal effects, interactions, and covariate mediation...
  6. Falls in the Community Dwelling Elderly with a History of Cancer
    SANDRA LEE SPOELSTRA; Fiscal Year: 2010
    ..The statistical approaches that accommodate the variables in this study are longitudinal Generalized Linear models and Generalized Estimating Equations...
  7. Dissemination of a Theory-Based Bone Health Program in Online Communities
    Eun Shim Nahm; Fiscal Year: 2012
    ..The primary analytic approach for the Effectiveness dimension will involve mixed linear models analyses. Other impact dimensions will be assessed using descriptive statistics...
  8. Meditation and Exercise for Preventing Acute Respiratory Infection (MEPARI-2)
    Bruce P Barrett; Fiscal Year: 2013
    ..Generalized estimating equations, random-effects pattern-mixture models, and hierarchical linear models will be used to assess longitudinal effects, interactions, and covariate mediation.
  9. Alcohol treatment & health disparity in American Indians
    R Walker; Fiscal Year: 2009
    ..Hierarchical linear models and structural equations models will be used to relate treatments to outcomes...
  10. Aqueous Humor Dynamic Components that Determine Intraocular Pressure Variance
    Sayoko E Moroi; Fiscal Year: 2013
    ..The relationships among these four physiological components to IOP will be analyzed by generalized linear models. These results will provide a critically needed database on physiological components of IOP under baseline and ..
  11. Genome Wide Association of Coronary Artery Disease and Related Risk Factors
    Ulrich Broeckel; Fiscal Year: 2012
    ..For the statistical analysis we will use standard analysis and linear models that consider the direct association of a SNP (or haplotype, or diplotype) on a trait while accounting for and ..
  12. EMA Assessment of Biobehavioral Processes in Human Pregnancy
    Pathik D Wadhwa; Fiscal Year: 2013
    ..estimating equations (GEE) and multi-level mixed models with fixed and random effects (hierarchical linear models;HLM)...
  13. Genetics, family environment, and neighborhood: impact on mental disorders
    JAN O SUNDQUIST; Fiscal Year: 2013
    ..risk of psychiatric disorders will be estimated by Structural Equation Modeling and Multilevel and General Linear Models when appropriate...
  14. Constitutive and Agent-Based Multiscale Models to Improve Vein Graft Survival
    Rongling Wu; Fiscal Year: 2013
    ..aimed at improving the durability of vein grafts have focused largely on reductionist strategies and used linear models to describe the physical and biologic components of vascular disease progression...
  15. Improving decision making for patients with prolonged mechanical ventilation
    CHRISTOPHER ETHAN COX; Fiscal Year: 2013
    ..We will use generalized linear models to test for differences in outcomes between decision aid and usual care control groups over a 6-month follow ..
  16. fMRI Correlates of Olfactory and Visual Cues in Tobacco Smoking
    STEVEN BRADLEY LOWEN; Fiscal Year: 2010
    ..Generalized linear models (GLM) are the standard analysis method for functional scans...
  17. Causal Mediation Analysis of Dental Caries in VLBW and BPD Adolescents
    Jeffrey M Albert; Fiscal Year: 2010
    ..method which translates and elaborates a proposed causal diagram into a system of easily fitted generalized linear models. This general context will allow us to incorporate specialized models, such as the zero-inflated Poisson, for ..
  18. Improving Gastrointestinal Disease Outcomes in Vulnerable Populations
    JOHN MATTHEW INADOMI; Fiscal Year: 2012
    ..Data Analysis: Chi-square testing of proportions and generalized linear models. Public health: This grant will support mentorship of young investigators interested in patient-oriented ..
  19. Role of metabolic syndrome and inflamamation on physical function in the elderly
    KRISTEN MARIE BEAVERS; Fiscal Year: 2012
    ..such as Foundations of Clinical and Translational Science, Epidemiology, Clinical Trial Methods, and Applied Linear Models. Completion of these courses will provide a more comprehensive understanding of statistical and ..
  20. Neighborhood Context, Social Relationships, and Health: Examining the Pathways
    Jennifer Ailshire; Fiscal Year: 2013
    ..A combination of generalized linear models and multilevel methods will be used to conduct the analyses outlined in the specific aims...
  21. Predicting Morbidity from Pediatric Critical Care
    MURRAY MICHAEL POLLACK; Fiscal Year: 2013
    ..for multiple functional states with normal function and death being the extreme will include both "simple" linear models with the FSS contributing the gradations of outcome, and polychotomous logistic regression analysis for models ..
  22. Adolescent Sex Hormones and Breast Density in Young Women
    Joanne F Dorgan; Fiscal Year: 2013
    ..We will use multilevel linear models to evaluate associations of adolescent serum sex hormone levels with breast density in 177 DISC participants ..
  23. MULTIPLE RISKS, DECISIONS & BEHAVIORS IN THE GENOMIC ERA
    Karen E Hurley; Fiscal Year: 2010
    ..molecular biology and advanced statistics (latent class analysis, growth curve analysis, hierarchical linear models, and automatic interaction detection)...
  24. Group Physical Therapy for Veterans with Knee Osteoarthritis
    Kelli D Allen; Fiscal Year: 2013
    ..Mixed linear models will be used to compare outcomes for the two study arms...
  25. ALSISE: Assessment of Life Science Intermediate School Educators
    PHILIP MICHAEL SADLER; Fiscal Year: 2010
    ..With the measurement of participant knowledge gains, the construction of hierarchical linear models will aid in revealing differences in approach to professional development (duration, group size, involvement ..
  26. The Role of Vascular Aging in Cognitive and Physical Function
    LYDIA BAZZANO; Fiscal Year: 2013
    ..be used to examine the relationship of early life risk factrs to subclinical vascular disease markers, while linear models will be used to examine the role of vascular risk factors and subclinical markers in maintenance of cognitive ..
  27. Dynamic markers of intraoperative instability
    Balachundhar Subramaniam; Fiscal Year: 2013
    ..fail to take into account fluctuations in physiologic control in individual patents and use simplified linear models that are unable to capture the complex, time varying features that are hallmarks of 'real-world'..
  28. Modeling of transient oxygen delivery in the brain
    David B Ress; Fiscal Year: 2012
    ..We will test how well these measurements are fit by our linear flow model as well as previous non-linear models. The proposed work will further vet our model, bringing it into the mainstream as a simple but powerful ..
  29. Flexible Statistical Methods for Biomedical Data
    Marie Davidian; Fiscal Year: 2013
    ..Linear and generalized linear models for independent data and their mixed-effects counterparts for longitudinal and other clustered data are widely ..
  30. Family Life and Child Obesity: Interactions that Matter
    Solveig Argeseanu Cunningham; Fiscal Year: 2012
    ..family activities and other covariates at 7 points over 9 years: first-difference regressions and hierarchical linear models will be used to explore relationships between changes in family structure and changes in weight and nutrition...
  31. Cardiac care in specialty and general hospitals
    Peter M Cram; Fiscal Year: 2010
    ..Three complementary methods will be used to minimize selection bias (hierarchcial linear models, propensity scores, and instrumental variables) and adjust for important patient-level, hospital-level, and ..
  32. Improving Problem-Solving Performance of Students with Mathematics Difficulties
    ASHA KIRON JITENDRA; Fiscal Year: 2010
    ..A set of hierarchical linear models will be estimated to investigate the effect of treatment on mathematical problem solving and student attitudes ..
  33. Expanding the Utility of Social Network Analysis for Multilevel Health Outcomes
    Brenda McCowan; Fiscal Year: 2013
    ..various social networks whose structure, dynamics, and robustness will be measured, and subsequently analyzed with respect to internal factors, health outcomes, and behavioral measures using multi-level generalized linear models.)
  34. Long-Term Outcomes of Nonmelanoma Skin Cancer
    Mary Margaret Chren; Fiscal Year: 2009
    ..Analyses. Mixed effects generalized linear models will be used to model the effect of treatment on outcomes, adjusting for patient, tumor, and clinician factors ..
  35. MRI Structural and Functional Connectivity Changes in Temporal Lobe Epilepsy
    Victoria L Morgan; Fiscal Year: 2013
    ..method, robust Biological Parametric Mapping (rBPM), will be used to develop multivariate, multimodal linear models of presurgical MRI connectivity, disease characteristics and neuropsychological test scores to predict post-..
  36. Parity, child mental health, and substance abuse
    ELLEN R MEARA; Fiscal Year: 2010
    ..observations on individuals, and using estimation strategies such as generalized Poisson or negative binomial models for count data and generalized linear models to address spending data, which are often highly skewed.
  37. Hierarchical Modeling and Parallelized Bayesian Inference for RNAseq Analysis
    DANIEL S NETTLETON; Fiscal Year: 2013
    ..In addition to the specific methods mentioned above, hierarchical generalized linear models for the simultaneous analysis of tens of thousands of response variables will be developed...
  38. Family Members of Alcohol Patients: Utilization and Cost
    Constance M Weisner; Fiscal Year: 2013
    ..of AODD family members and compare them to other demographically similar cohorts, we will use generalized linear models (for yearly comparison) and hierarchical linear models (for analysis of multi-year trends)...
  39. High-Dimensional Data Issues in Aging Research
    Bin Nan; Fiscal Year: 2013
    ..a novel convex penalty in multiple linear regression with high-dimensional grouped covariates, generalized linear models with high-dimensional grouped covariates, and multivariate linear regression with both high- dimensional ..
  40. Evaluation of Intervention for Siblings in Foster Care
    LEWIS I BANK; Fiscal Year: 2013
    ..Hierarchical Linear Models (HLM) and multiple regression analyses will be used to test (1) the prediction that SPMT siblings will improve ..
  41. A New Dimension in Renal Clearance Design Criteria for Dendrimer Nanostructures
    Erik C Wiener; Fiscal Year: 2010
    ..We use the maximum likelihood estimation and linear models for the variance of the additive errors...
  42. NEW STATISTICAL METHODS FOR MEDICAL SIGNALS AND IMAGES
    Iain M Johnstone; Fiscal Year: 2013
    ..investigators will study: 1) the Significance analysis of RNA-Seq comparative experiments using Poisson log linear models and a novel procedure to estimate the false discovery rate...
  43. Predictors of Hospital-Acquired Urinary Tract-Related Bloodstream Infection in VA
    Sanjay K Saint; Fiscal Year: 2013
    ..clustering by hospital location will be utilized for the analyses, as well as sliding time windows for log-linear models and cubic B-splines with time-specific weight functions...
  44. Understanding Processes of Care and Patient Safety Outcomes in Nursing Homes: An
    KALI ST MARIE THOMAS; Fiscal Year: 2010
    ..utilize an advanced statistical approach to model multilevel data, namely two-level hierarchical generalized linear models. The ultimate goal is to find ways to improve the quality of health care through an understanding of the ..
  45. Variance Modeling of Smoking-related EMA Data
    Donald Hedeker; Fiscal Year: 2010
    ..Thus, linear mixed models (LMMs, aka multilevel or hierarchical linear models) are increasingly used for analysis of EMA data...
  46. Unhealthy Drinking in Older Adults: 30-day Readmissions and Emergency Care
    LAURA JOHNSON CHAVEZ; Fiscal Year: 2013
    ..Generalized linear models will be used to examine the association between unhealthy alcohol use and total acute care costs in the 30 ..
  47. Sparse Structural Equation Models for Gene Networks and Chemical Genomics
    Xiaodong Cai; Fiscal Year: 2013
    Structural equation modeling unifies regression, factor analysis, directed graphs and other (non)linear models into a powerful and flexible toolbox for statistical inference...
  48. Improving Advance Care Planning by Preparing Diverse Seniors for Decision Making
    Rebecca L Sudore; Fiscal Year: 2013
    ..We will use mixed-effects generalized linear models to assess differences in longitudinal outcomes between arms and control for variables that differ between arms...
  49. The impact of quality end-of-life care in nursing homes
    SARAH ANN FORBES THOMPSON; Fiscal Year: 2010
    ..Analyses include generalized linear models, two-level linear mixed models, and two-level structural equation modeling...
  50. The Impact of Hospice Preferred Practices on Patient Outcomes and Hospice Costs
    MELISSA DIANE ALDRIDGE; Fiscal Year: 2013
    ..We will employ hierarchical generalized linear models to test the associations between hospice preferred practices and outcomes, accounting for patient, hospice, ..
  51. Drug Use Among Young Indians: Epidemiology &Prediction
    Frederick Beauvais; Fiscal Year: 2013
    ..Hierarchical linear models will be used to assess both the individual and school-level effects of the perceived normative environment for ..
  52. Implementation of Practice Standards for ECG Monitoring
    Marjorie Funk; Fiscal Year: 2012
    ..continuous outcomes, mixed modeling will be used to account for intra-cluster correlation through hierarchical linear models. We developed the new practice standards to improve hospital ECG monitoring...
  53. The Social Context of Social Loss
    Lauren A Lee; Fiscal Year: 2011
    ..Data analysis will occur in a multilevel modeling framework using linear and non-linear models, lower-level mediation, and path analysis...
  54. Factors that Promote and Support Careers of Women of Color in Academic Medicine
    Joan Y Reede; Fiscal Year: 2012
    ..Analysis will include basic descriptive statistics, as well as the use of hierarchical generalized linear models. The study will significantly contribute to an understanding of factors that are critical to the career ..
  55. Bioinformatics Strategies: Biodefense Vaccine Research
    Jason H Moore; Fiscal Year: 2012
    ..The inclusion of new methods such as stochastic search algorithms for genome-wide analysis and linear models for continuous endpoints will ensure that the MDR software stays on the cutting edge...
  56. Improving Mental Health Outcomes of Child Brain Injury
    Shari L Wade; Fiscal Year: 2010
    ..Families will be randomly assigned to one of two conditions. Group differences will be examined using mixed linear models for continuous outcomes and Generalized Estimation Equations (GEE) for dichotomous outcomes...
  57. Profile of Symptom Clusters Among Prostate Cancer Patients
    Shannon Ruff Dirksen; Fiscal Year: 2010
    ..Mixed effects linear models will be used to assess the relationship between symptom clusters, quality of life, and biomarkers...
  58. Health Disparities Among a Vulnerable Population: A Longitudinal Analysis
    Stefanie Mollborn; Fiscal Year: 2011
    ..these cutting-edge data, we will employ a series of innovative statistical techniques including generalized linear models, propensity score matching, multi-level models, and latent curve models...
  59. Bayesian Methods for Genome-Wide Interacting QTL Mapping
    Nengjun Yi; Fiscal Year: 2013
    ..The proposed approach incorporates all advantages of generalized linear models and hierarchical modeling into genome-wide analysis of interacting genes, allowing us to deal with various ..
  60. METHODS FOR INCOMPLETE MENTAL HEALTH SERVICES DATA
    Thomas Belin; Fiscal Year: 2001
    ..Using data from multiple sources, log linear models can be estimated on the subset which has data from all sources...
  61. Bayesian Variable Selection in Generalized Linear Models with Missing Varibles
    Xiaowei Yang; Fiscal Year: 2013
    ..nonresponse and dropout) and technical reasons (e.g., censoring over/below quantization level). Generalized linear models (GLMs) are popularly applied in biomedical data analysis where a fundamental task is to interpret or predict ..
  62. Dissemination of Amputation and Prosthetic Evidenced-based Medicine (DAP-EM)
    SANDRA L WINKLER; Fiscal Year: 2013
    ..Aims 2 and 4 will use qualitative methods based on Grounded (Aim 2) and Interpretative Phenomenological Approaches (Aim 4). Aim 3 will use a quantitative randomized control design and generalized linear models for analyses.
  63. Effectiveness of Recovery High Schools as Continuing Care
    Ken C Winters; Fiscal Year: 2013
    ..Hierarchical linear models that represent treatment providers as a blocking factor and account for nesting of students within schools ..
  64. Polysomnography in Homeopathic Remedy Effects
    Iris Bell; Fiscal Year: 2007
    ..Statistical analyses will include hierarchical linear models and general linear models...
  65. Prenatal Testosterone and Risk for Disordered Eating During Puberty
    KRISTEN CULBERT; Fiscal Year: 2009
    ..Adiposity will be assessed with bioelectrical impedance and body mass index. Hierarchal Linear Models will be used to examine differences in DE by twin type (opposite-or same-sex) and puberty status (pre-pubertal,..
  66. Decision Making in Patients with Advanced Prostate Cancer
    Randy Jones; Fiscal Year: 2009
    ..The decision aid will be administered during two clinic visits. Generalized linear models will be used for data analysis for the quantitative component;saturation of themes will be used for the ..
  67. VALIDATING THE SAFETY OF NURSE-HEALTH ADVOCATE SERVICES
    KARLA NACION; Fiscal Year: 1992
    ..Log-linear models will be used to analyze the proportion of agreement/disagreement between the MCHAs and the nurses in the needs,..
  68. Effects of Soy on Estrogens in Breast Fluid and Urine
    Gertraud Maskarinec; Fiscal Year: 2010
    ..The statistical analysis will apply general linear models to compare hormone levels, cytology of breast cells, and urinary estrogen metabolites by soy intake, while ..
  69. Predictors of Hospital-Acquired Urinary Tract-Related Bloodstream Infection
    Sanjay Saint; Fiscal Year: 2009
    ..regression with clustering by ward will be utilized for the analyses, as well as sliding time windows for log-linear models and cubic B-splines with time-specific weight functions...
  70. Neighborhood SES and Emotional Distress in Old Age
    CAROL ANESHENSEL; Fiscal Year: 2009
    ..Methods of analysis include hierarchical linear models, combined growth curve and cross-nested random effects models, and multilevel Cox proportional hazard models...
  71. The role of selection and genetic diversity in cancer progression
    LAUREN MERLO; Fiscal Year: 2009
    ..effects of specific genetic lesions in Barrett's esophagus allowing us to directly test hypothesized linear models of progression in this system and to determine the fitness effects of newly identified mutations common in ..
  72. Selegiline for Smoking Cessation
    MARC POTENZA; Fiscal Year: 2007
    ..logistic regression analyses to determine the effects of selegiline on cessation outcomes, and hierarchical linear models (HLM) for continuous outcomes (e.g., craving and withdrawal, weight, depressive symptoms)...
  73. Payees, Disability Payments and Dual Diagnosis
    Marc Rosen; Fiscal Year: 2006
    ..Multi-level hierarchical linear models will represent the fact that outcomes over time are nested within subjects, and subjects are nested within ..
  74. Tree Ensemble Regression and Classification Methods
    JAMES SCHIMERT; Fiscal Year: 2004
    ..Generalized forest models extend regression forests in the same way that generalized linear models extend linear models...
  75. CONSEQUENCES OF PHYSICAL RESTRAINTS
    Nicholas Castle; Fiscal Year: 2004
    ..We propose to use linear models of change that are less susceptible to this bias...
  76. VICTIMS OF VIOLENCE--FAMILY RISK FOR PTSD FOLLOWING RAPE
    Jonathan Davidson; Fiscal Year: 1993
    ..Log linear models will be also be used...
  77. Contraceptive in Women with Prior Gestational Diabetes
    Anny Xiang; Fiscal Year: 2005
    ..Survival analysis will be use to compare diabetes rates among forms of contraception. Generalized linear models will be used to compare effects on glucose, blood pressure and lipid levels...
  78. LIVING ARRANGEMENTS AND HEALTH STATUS IN LATE LIFE
    JUDITH HAYS; Fiscal Year: 2002
    ..include coursework in scale construction and validation, structural equation models, and hierarchial linear models; and, in consultation with mentors, validation of new standardized methods for assessing late life attachments ..
  79. Organizational Culture's Impact Across the Nursing Home Industry
    Jane Banaszak Holl; Fiscal Year: 2009
    ..Subsequently, generalized linear models with corrections for grouped variance within states will be used to estimate the effects of organizational ..