roc curve


Summary: A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli.

Top Publications

  1. ncbi Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study
    F Imbert-Bismut
    Department of Biochemistry, , Paris, France
    Lancet 357:1069-75. 2001
  2. ncbi Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer
    Yixin Wang
    Veridex LLC, a Johnson and Johnson Company, San Diego, CA, USA
    Lancet 365:671-9. 2005
  3. ncbi Prediction of incident diabetes mellitus in middle-aged adults: the Framingham Offspring Study
    Peter W F Wilson
    Emory Program in Cardiovascular Outcomes Research and Epidemiology, Emory University School of Medicine, Atlanta, GA 30306, USA
    Arch Intern Med 167:1068-74. 2007
  4. ncbi Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond
    Michael J Pencina
    Department of Mathematics and Statistics, Framingham Heart Study, Boston University, Boston, MA 02215, USA
    Stat Med 27:157-72; discussion 207-12. 2008
  5. ncbi ROCR: visualizing classifier performance in R
    Tobias Sing
    Department of Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, Saarbrucken, Germany
    Bioinformatics 21:3940-1. 2005
  6. pmc Assessing the performance of prediction models: a framework for traditional and novel measures
    Ewout W Steyerberg
    Department of Public Health, Erasmus MC, Rotterdam, The Netherlands
    Epidemiology 21:128-38. 2010
  7. ncbi The performance of tests of publication bias and other sample size effects in systematic reviews of diagnostic test accuracy was assessed
    Jonathan J Deeks
    Screening and Test Evaluation Program, School of Public Health, University of Sydney, Sydney, New South Wales 2006, Australia
    J Clin Epidemiol 58:882-93. 2005
  8. ncbi Use and misuse of the receiver operating characteristic curve in risk prediction
    Nancy R Cook
    Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave East, Boston, MA 02215, USA
    Circulation 115:928-35. 2007
  9. ncbi Understanding diagnostic tests 3: Receiver operating characteristic curves
    Anthony K Akobeng
    Department of Paediatric Gastroenterology, Central Manchester and Manchester Children s University Hospitals, Booth Hall Children s Hospital, Manchester, UK
    Acta Paediatr 96:644-7. 2007
  10. pmc Systematic reviews of diagnostic test accuracy
    Mariska M G Leeflang
    Dutch Cochrane Centre and Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Ann Intern Med 149:889-97. 2008

Detail Information

Publications383 found, 100 shown here

  1. ncbi Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study
    F Imbert-Bismut
    Department of Biochemistry, , Paris, France
    Lancet 357:1069-75. 2001
    ..60 to 1.00 (34% [115] of all patients). INTERPRETATION: A combination of basic serum markers could be used to substantially reduce the number of liver biopsies done in patients with chronic HCV infection...
  2. ncbi Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer
    Yixin Wang
    Veridex LLC, a Johnson and Johnson Company, San Diego, CA, USA
    Lancet 365:671-9. 2005
  3. ncbi Prediction of incident diabetes mellitus in middle-aged adults: the Framingham Offspring Study
    Peter W F Wilson
    Emory Program in Cardiovascular Outcomes Research and Epidemiology, Emory University School of Medicine, Atlanta, GA 30306, USA
    Arch Intern Med 167:1068-74. 2007
    ..Prediction rules for type 2 diabetes mellitus (T2DM) have been developed, but we lack consensus for the most effective approach...
  4. ncbi Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond
    Michael J Pencina
    Department of Mathematics and Statistics, Framingham Heart Study, Boston University, Boston, MA 02215, USA
    Stat Med 27:157-72; discussion 207-12. 2008
    ..We illustrate the use of these measures with an example from the Framingham Heart Study. We propose that scientists consider these types of measures in addition to the AUC when assessing the performance of newer biomarkers...
  5. ncbi ROCR: visualizing classifier performance in R
    Tobias Sing
    Department of Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, Saarbrucken, Germany
    Bioinformatics 21:3940-1. 2005
    ..Being equipped with only three commands and reasonable default values for optional parameters, ROCR combines flexibility with ease of usage...
  6. pmc Assessing the performance of prediction models: a framework for traditional and novel measures
    Ewout W Steyerberg
    Department of Public Health, Erasmus MC, Rotterdam, The Netherlands
    Epidemiology 21:128-38. 2010
    ..Other measures of performance may be warranted in specific applications, such as reclassification metrics to gain insight into the value of adding a novel predictor to an established model...
  7. ncbi The performance of tests of publication bias and other sample size effects in systematic reviews of diagnostic test accuracy was assessed
    Jonathan J Deeks
    Screening and Test Evaluation Program, School of Public Health, University of Sydney, Sydney, New South Wales 2006, Australia
    J Clin Epidemiol 58:882-93. 2005
    ..We investigate limitations of standard funnel plots and tests when applied to meta-analyses of test accuracy and look for improved methods...
  8. ncbi Use and misuse of the receiver operating characteristic curve in risk prediction
    Nancy R Cook
    Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave East, Boston, MA 02215, USA
    Circulation 115:928-35. 2007
    ..As novel risk factors are discovered, sole reliance on the c statistic to evaluate their utility as risk predictors thus seems ill-advised...
  9. ncbi Understanding diagnostic tests 3: Receiver operating characteristic curves
    Anthony K Akobeng
    Department of Paediatric Gastroenterology, Central Manchester and Manchester Children s University Hospitals, Booth Hall Children s Hospital, Manchester, UK
    Acta Paediatr 96:644-7. 2007
    ..Two methods commonly used to establish the optimal cut-off point include the point on the ROC curve closest to (0, 1) and the Youden index...
  10. pmc Systematic reviews of diagnostic test accuracy
    Mariska M G Leeflang
    Dutch Cochrane Centre and Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Ann Intern Med 149:889-97. 2008
    ..Challenges that remain are the poor reporting of original diagnostic test accuracy studies and difficulties with the interpretation of the results of diagnostic test accuracy research...
  11. ncbi Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C
    Laurent Castera
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, C H U Bordeaux, Pessac, France
    Gastroenterology 128:343-50. 2005
  12. ncbi Time-dependent ROC curves for censored survival data and a diagnostic marker
    P J Heagerty
    Department of Biostatistics, University of Washington, Seattle 98195, USA
    Biometrics 56:337-44. 2000
    ..A typical complexity with survival data is that observations may be censored. Two ROC curve estimators are proposed that can accommodate censored data...
  13. ncbi Bivariate analysis of sensitivity and specificity produces informative summary measures in diagnostic reviews
    Johannes B Reitsma
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    J Clin Epidemiol 58:982-90. 2005
    ..Studies of diagnostic accuracy most often report pairs of sensitivity and specificity. We demonstrate the advantage of using bivariate meta-regression models to analyze such data...
  14. ncbi Estimation of the Youden Index and its associated cutoff point
    Ronen Fluss
    Department of Statistics, University of Haifa 31905, Israel
    Biom J 47:458-72. 2005
    ..In the estimation of the Youden Index the kernel is generally the best unless the data can be well transformed to achieve normality whereas in estimation of the optimal threshold value results are more variable...
  15. ncbi Simple scoring scheme for calculating the risk of acute coronary events based on the 10-year follow-up of the prospective cardiovascular Münster (PROCAM) study
    Gerd Assmann
    Institute of Arteriosclerosis Research at the University of Münster, Germany
    Circulation 105:310-5. 2002
    ..Although several scoring schemes have been suggested to calculate this profile, many omit information on important variables such as family history of coronary heart disease or LDL cholesterol...
  16. ncbi Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection
    Richard K Sterling
    Section of Hepatology, Virginia Commonwealth University Health System, Richmond, VA 23298 0341, USA
    Hepatology 43:1317-25. 2006
    ..In conclusion, noninvasive tests can accurately predict hepatic fibrosis and may reduce the need for liver biopsy in the majority of HIV/HCV-coinfected patients...
  17. ncbi A five-microRNA signature identified from genome-wide serum microRNA expression profiling serves as a fingerprint for gastric cancer diagnosis
    Rui Liu
    Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin, 210008, China
    Eur J Cancer 47:784-91. 2011
    ..The purpose of present study was to identify a serum microRNA (miRNA) expression profile that can serve as a novel diagnostic biomarker for GC detection and to assess its clinical applications in monitoring disease progression...
  18. ncbi A hierarchical regression approach to meta-analysis of diagnostic test accuracy evaluations
    C M Rutter
    Group Health Cooperative, Center for Health Studies, 1730 Minor Avenue, Suite 1600, Seattle, WA 98101, USA
    Stat Med 20:2865-84. 2001
    ..We demonstrate the advantages of this modelling approach using a recently published meta-analysis comparing three tests used to detect nodal metastasis of cervical cancer...
  19. ncbi Diagnostic performance of coronary angiography by 64-row CT
    Julie M Miller
    Johns Hopkins University School of Medicine, Baltimore 21287, USA
    N Engl J Med 359:2324-36. 2008
    ..The accuracy of multidetector computed tomographic (CT) angiography involving 64 detectors has not been well established...
  20. ncbi The use of receiver operating characteristic curves in biomedical informatics
    Thomas A Lasko
    Decision Systems Group, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Biomed Inform 38:404-15. 2005
    ..In this article, we review the basic concepts of ROC analysis, illustrate their use with sample calculations, make recommendations drawn from the literature, and list readily available software...
  21. pmc The genetic interpretation of area under the ROC curve in genomic profiling
    Naomi R Wray
    Genetic Epidemiology and Queensland Statistical Genetics, Queensland Institute of Medical Research, Brisbane, Australia
    PLoS Genet 6:e1000864. 2010
    ..We use quantitative genetics theory to provide insight into the genetic interpretation of the area under the ROC curve (AUC) when the test classifier is a predictor of genetic risk...
  22. pmc Statistics review 13: receiver operating characteristic curves
    Viv Bewick
    School of Computing, Mathematical and Information Sciences, University of Brighton, Brighton, UK
    Crit Care 8:508-12. 2004
    ..The sensitivity, specificity and likelihood ratio of a test are discussed. The uses of the receiver operating characteristic curve and the area under the curve are explained...
  23. ncbi Optimal cut-point and its corresponding Youden Index to discriminate individuals using pooled blood samples
    Enrique F Schisterman
    Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, DHHS, Bethesda, Maryland, USA
    Epidemiology 16:73-81. 2005
    ..More importantly, J is the maximum vertical distance or difference between the ROC curve and the diagonal or chance line; it occurs at the cut-point that optimizes the biomarker's differentiating ..
  24. ncbi Performance of transient elastography for the staging of liver fibrosis: a meta-analysis
    Mireen Friedrich-Rust
    Department of Internal Medicine I, J W Goethe University Hospital, Frankfurt, Germany
    Gastroenterology 134:960-74. 2008
    ..A meta-analysis was performed to assess the overall performance of transient elastography for the diagnosis of liver fibrosis and to analyze factors influencing the diagnostic accuracy...
  25. ncbi Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysis
    Bernard Uzzan
    APHP Laboratoire de Pharmacologie Hormonologie, Hopital Avicenne, Bobigny, France
    Crit Care Med 34:1996-2003. 2006
    ..To draw and compare the summary receiver operating characteristics curves for procalcitonin and C-reactive protein from the literature...
  26. ncbi Factors influencing serum cystatin C levels other than renal function and the impact on renal function measurement
    Eric L Knight
    Channing Laboratory, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 65:1416-21. 2004
  27. ncbi Early diagnosis of myocardial infarction with sensitive cardiac troponin assays
    Tobias Reichlin
    Department of Internal Medicine, University Hospital, Basel, Switzerland
    N Engl J Med 361:858-67. 2009
    ..The rapid and reliable diagnosis of acute myocardial infarction is a major unmet clinical need...
  28. pmc Diagnosis of cirrhosis by transient elastography (FibroScan): a prospective study
    J Foucher
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, Avenue Magellan, 33604 Pessac, France
    Gut 55:403-8. 2006
    ..5 kPa. However, the clinical relevance of these values is unknown. The aim of this prospective study was to evaluate the accuracy of liver stiffness measurement for the detection of cirrhosis in patients with chronic liver disease...
  29. ncbi Properties of the summary receiver operating characteristic (SROC) curve for diagnostic test data
    S D Walter
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Stat Med 21:1237-56. 2002
    ..The methods are illustrated using data for the Pap smear screening test for cervical cancer, and for three tests for the diagnosis of metastases in cervical cancer patients...
  30. pmc Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study
    Kerby Shedden
    Department of Statistics, 1085 South University, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Med 14:822-7. 2008
    ..This study also provides the largest available set of microarray data with extensive pathological and clinical annotation for lung adenocarcinomas...
  31. ncbi Dynamic modularity in protein interaction networks predicts breast cancer outcome
    Ian W Taylor
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Ave, Toronto, Ontario M5G 1X5, Canada
    Nat Biotechnol 27:199-204. 2009
    ..Analysis of two breast cancer patient cohorts revealed that altered modularity of the human interactome may be useful as an indicator of breast cancer prognosis...
  32. ncbi Operating characteristics of prostate-specific antigen in men with an initial PSA level of 3.0 ng/ml or lower
    Ian M Thompson
    Department of Urology, University of Texas Health Science Center at San Antonio, TX 78229, USA
    JAMA 294:66-70. 2005
    ..Three fourths of US men older than 50 years have been screened with prostate-specific antigen (PSA) for prostate cancer...
  33. pmc Performance of common genetic variants in breast-cancer risk models
    Sholom Wacholder
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 5050, MSC 7244, Bethesda, MD 20892, USA
    N Engl J Med 362:986-93. 2010
    ..Genomewide association studies have identified multiple genetic variants associated with breast cancer. The extent to which these variants add to existing risk-assessment models is unknown...
  34. ncbi Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia
    Sebastien Gibot
    Service de Reanimation Medicale, Hopital Central, Nancy, France
    N Engl J Med 350:451-8. 2004
    ..The presence of soluble TREM-1 (sTREM-1) in bronchoalveolar-lavage fluid from patients receiving mechanical ventilation may be an indicator of pneumonia...
  35. ncbi Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: a large-scale, multicentre study
    Qiujin Shen
    State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Lancet Oncol 13:817-26. 2012
    ..Hepatocellular carcinoma (HCC) is prevalent worldwide and improvements in timely and effective diagnosis are needed. We assessed whether measurement of Dickkopf-1 (DKK1) in serum could improve diagnostic accuracy for HCC...
  36. pmc Urinary biomarkers and renal recovery in critically ill patients with renal support
    Nattachai Srisawat
    604 Scaife Hall, Department of Critical Care Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Clin J Am Soc Nephrol 6:1815-23. 2011
    ..Unfortunately, no reliable method to predict renal recovery exists. The discovery of biomarkers to aid in clinical risk prediction for recovery after AKI would represent a significant advance over current practice...
  37. pmc A unifying framework for evaluating the predictive power of genetic variants based on the level of heritability explained
    Hon Cheong So
    Department of Psychiatry, University of Hong Kong, Hong Kong, China
    PLoS Genet 6:e1001230. 2010
    ..We also demonstrate how to construct graphs to visualize the performance of risk models, such as the ROC curve, the density of risks, and the predictiveness curve (disease risk plotted against risk percentile)...
  38. ncbi Detection and characterisation of focal liver lesions in colorectal carcinoma patients: comparison of diffusion-weighted and Gd-EOB-DTPA enhanced MR imaging
    D Lowenthal
    Department of Radiology and Nuclear Medicine, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Eur Radiol 21:832-40. 2011
    ..To compare diffusion-weighted imaging (DWI) and Gd-EOB-DTPA-enhanced magnetic resonance (MR) imaging for the detection and characterisation of focal liver lesions (FLLs) in patients with colorectal carcinoma...
  39. ncbi Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with chronic hepatitis C
    Marianne Ziol
    UPRES EA 3406, University of Paris 13, Bobigny, France
    Hepatology 41:48-54. 2005
    ..In conclusion, noninvasive assessment of liver stiffness with transient elastography appears as a reliable tool to detect significant fibrosis or cirrhosis in patients with chronic hepatitis C...
  40. pmc Prediction model for prevalence and incidence of advanced age-related macular degeneration based on genetic, demographic, and environmental variables
    Johanna M Seddon
    Ophthalmic Epidemiology and Genetics Service, Tufts University School of Medicine and Tufts Medical Center, Boston, Massachusetts 02111, USA
    Invest Ophthalmol Vis Sci 50:2044-53. 2009
    ..The joint effects of genetic, ocular, and environmental variables were evaluated and predictive models for prevalence and incidence of AMD were assessed...
  41. pmc pROC: an open-source package for R and S+ to analyze and compare ROC curves
    Xavier Robin
    Biomedical Proteomics Research Group, Department of Structural Biology and Bioinformatics, Medical University Centre, Geneva, Switzerland
    BMC Bioinformatics 12:77. 2011
  42. pmc Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry
    Marilyn C Cornelis
    Harvard School of Public Health, Channing Laboratory, Boston, MA 02115, USA
    Ann Intern Med 150:541-50. 2009
    ..Genome-wide association studies have identified novel type 2 diabetes loci, each of which has a modest impact on risk...
  43. ncbi Statistical evaluation of prognostic versus diagnostic models: beyond the ROC curve
    Nancy R Cook
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Clin Chem 54:17-23. 2008
    ..Diagnostic and prognostic or predictive models serve different purposes. Whereas diagnostic models are usually used for classification, prognostic models incorporate the dimension of time, adding a stochastic element...
  44. ncbi Neutrophil-to-lymphocyte ratio associated with mortality in early hepatocellular carcinoma patients after radiofrequency ablation
    Tsung Ming Chen
    Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
    J Gastroenterol Hepatol 27:553-61. 2012
    ..We studied whether peripheral blood neutrophil-to-lymphocyte ratio (NLR), a marker of systemic inflammatory response, would be a useful predictor for outcome in patients with early HCC undergoing radiofrequency ablation (RFA)...
  45. ncbi APTIMA PCA3 molecular urine test: development of a method to aid in the diagnosis of prostate cancer
    Jack Groskopf
    Gen Probe Incorporated, San Diego, CA 92121, USA
    Clin Chem 52:1089-95. 2006
    ..Prostate cancer gene 3 (PCA3) encodes a prostate-specific mRNA that has shown promise as a prostate cancer diagnostic tool. This report describes the characterization of a prototype quantitative PCA3-based test for whole urine...
  46. ncbi Increase of microRNA miR-31 level in plasma could be a potential marker of oral cancer
    C J Liu
    Institute of Oral Biology, School of Dentistry, National Yang Ming University, Taipei, Taiwan
    Oral Dis 16:360-4. 2010
    ..miR-31 was found markedly up-regulated in OSCC and several other malignancies. However, miR-31 expression was also down-regulated in the metastasis process of breast carcinoma...
  47. ncbi Elevated Beclin 1 expression is correlated with HIF-1alpha in predicting poor prognosis of nasopharyngeal carcinoma
    Xiang Bo Wan
    State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Autophagy 6:395-404. 2010
    ..HI F-1alpha-associated Beclin 1 high expression might facilitate NPC cells surviving from chemoradiotherapy, suggesting a novel therapeutic molecular target for NPC...
  48. ncbi MiR423-5p as a circulating biomarker for heart failure
    Anke J Tijsen
    Heart Failure Research Center, Academic Medical Center, Meibergdreef 15, Amsterdam, The Netherlands
    Circ Res 106:1035-9. 2010
    ..Aberrant expression profiles of circulating microRNAs (miRNAs) have been described in various diseases and provide high sensitivity and specificity. We explored circulating miRNAs as potential biomarkers in patients with heart failure (HF)...
  49. ncbi A nomogram for predicting the likelihood of additional nodal metastases in breast cancer patients with a positive sentinel node biopsy
    Kimberly J Van Zee
    Departments of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Ann Surg Oncol 10:1140-51. 2003
    ..Accurate estimates of the likelihood of additional disease in the axilla could assist greatly in decision-making regarding further treatment...
  50. pmc Multicenter validation of the diagnostic accuracy of a blood-based gene expression test for assessing obstructive coronary artery disease in nondiabetic patients
    Steven Rosenberg
    CardioDx, Palo Alto, California, USA
    Ann Intern Med 153:425-34. 2010
    ..Previous studies have suggested that peripheral blood gene expression can indicate the presence of CAD...
  51. ncbi HbA(1c) as a screening tool for detection of Type 2 diabetes: a systematic review
    C M Bennett
    Department of Public Health, School of Population Health, The University of Melbourne, Australia
    Diabet Med 24:333-43. 2007
    ..To assess the validity of glycated haemoglobin A(1c) (HbA(1c)) as a screening tool for early detection of Type 2 diabetes...
  52. ncbi Open mass spectrometry search algorithm
    Lewis Y Geer
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA
    J Proteome Res 3:958-64. 2004
    ..At default thresholds, OMSSA matches more spectra from a standard protein cocktail than a comparable algorithm. OMSSA is designed to be faster than published algorithms in searching large MS/MS datasets...
  53. ncbi Association of left-heart dysfunction with severe exacerbation of chronic obstructive pulmonary disease: diagnostic performance of cardiac biomarkers
    Fekri Abroug
    Intensive Care Unit, Department of Cardiology and Biochemistry Laboratory, Fattouma Bourguiba University Hospital, Monastir, Tunisia
    Am J Respir Crit Care Med 174:990-6. 2006
    ..However, they have not been assessed in the specific setting of acute exacerbation of chronic obstructive pulmonary disease (AECOPD), where they might be released without left-heart impairment...
  54. ncbi A unification of models for meta-analysis of diagnostic accuracy studies
    Roger M Harbord
    Medical Research Council Health Services Research Collaboration, Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol, UK
    Biostatistics 8:239-51. 2007
    ..We discuss the different forms of summary model output suggested by the two approaches, including summary ROC curves, summary points, confidence regions, and prediction regions...
  55. ncbi Expression profile of microRNAs in serum: a fingerprint for esophageal squamous cell carcinoma
    Chunni Zhang
    Department of Clinical Laboratory, Jinling Hospital, Clinical School of Medical College, Nanjing University, Nanjing, China
    Clin Chem 56:1871-9. 2010
    ..In this study, we investigated the serum miRNA profile in ESCC patients to develop a novel diagnostic ESCC biomarker...
  56. ncbi Detection of circulating tumor cells in peripheral blood from patients with gastric cancer using microRNA as a marker
    Hui Zhou
    Ningbo University School of Medicine, Ningbo 315211, China
    J Mol Med (Berl) 88:709-17. 2010
    ..The areas under the ROC curve for miR-106a, miR-17, and combination were 0.684 (p = 0.0066), 0.743 (p = 0.0001), and 0.741 (p = 0...
  57. ncbi European system for cardiac operative risk evaluation (EuroSCORE)
    S A Nashef
    Papworth Hospital, Cambridge, UK
    Eur J Cardiothorac Surg 16:9-13. 1999
    ..To construct a scoring system for the prediction of early mortality in cardiac surgical patients in Europe on the basis of objective risk factors...
  58. pmc Proinflammatory and proapoptotic markers in relation to mono and di-cations in plasma of autistic patients from Saudi Arabia
    Afaf K El-Ansary
    Biochemistry Department, Science College, King Saud University, P, O Box 22452, Zip code 11495, Riyadh, Saudi Arabia
    J Neuroinflammation 8:142. 2011
    ..This study aims to clarify the relationship amongst absolute and relative concentrations of K+, Na+, Ca2+, Mg2+ and/or proinflammatory and proapoptotic biomarkers...
  59. ncbi How can we enhance the performance of liver stiffness measurement using FibroScan in diagnosing liver cirrhosis in patients with chronic hepatitis B?
    Seung Up Kim
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    J Clin Gastroenterol 44:66-71. 2010
  60. ncbi Gene prioritization through genomic data fusion
    Stein Aerts
    Laboratory of Neurogenetics, Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology VIB, University of Leuven, Herestraat 49, bus 602, 3000 Leuven, Belgium
    Nat Biotechnol 24:537-44. 2006
    ..The approach described here offers an alternative integrative method for gene discovery...
  61. ncbi Decreased expression of PinX1 protein is correlated with tumor development and is a new independent poor prognostic factor in ovarian carcinoma
    Mu Yan Cai
    Sun Yat Sen University, Guangzhou, China
    Cancer Sci 101:1543-9. 2010
    ..Our findings suggest that loss of PinX1 is an adverse independent molecular marker for epithelial ovarian carcinoma patients. PinX1 may be a novel target for telomerase-based anticancer therapy due to inhibiting telomerase activity...
  62. ncbi A novel panel of cerebrospinal fluid biomarkers for the differential diagnosis of Alzheimer's disease versus normal aging and frontotemporal dementia
    A H Simonsen
    Biomarker Discovery Center Facility, Ciphergen Biosystems Inc, Copenhagen, Denmark
    Dement Geriatr Cogn Disord 24:434-40. 2007
    ..An early and accurate diagnosis of Alzheimer's disease (AD) is important in order to initiate symptomatic treatment with currently approved drugs and will be of even greater importance with the advent of disease-modifying compounds...
  63. ncbi Persisting high levels of plasma pentraxin 3 over the first days after severe sepsis and septic shock onset are associated with mortality
    Tommaso Mauri
    Dipartimento di Medicina Perioperatoria e Terapie Intensive, Azienda Ospedaliera San Gerardo di Monza, Via Pergolesi 33, 20052, Monza, Italy
    Intensive Care Med 36:621-9. 2010
    ..During sepsis a massive inflammatory activation and coagulation/fibrinolysis dysfunction occur. PTX3, as a mediator of inflammation, may represent an early marker of severity and outcome in sepsis...
  64. ncbi Quantification of free circulating DNA as a diagnostic marker in lung cancer
    Gabriella Sozzi
    Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy
    J Clin Oncol 21:3902-8. 2003
    ..This study was designed to assess the sensitivity and specificity of a quantitative molecular assay of circulating DNA to identify patients with lung cancer and monitor their disease...
  65. ncbi Accelerometer assessment of physical activity in children: an update
    Ann V Rowlands
    Children s Health and Exercise Research Centre, School of Sport and Health Sciences, University of Exeter, UK
    Pediatr Exerc Sci 19:252-66. 2007
  66. pmc Evaluation of GO-based functional similarity measures using S. cerevisiae protein interaction and expression profile data
    Tao Xu
    Shanghai MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center, Shanghai, PR China
    BMC Bioinformatics 9:472. 2008
    ..However, biologists are more interested in the relationship between gene products than in the scores linking the GO terms. To highlight the relationships among genes, recent studies have focused on functional similarities...
  67. ncbi Receiver-operating characteristic curves and likelihood ratios: improvements over traditional methods for the evaluation and application of veterinary clinical pathology tests
    Ian A Gardner
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California Davis, Davis, CA, USA
    Vet Clin Pathol 35:8-17. 2006
    ..basis from the empirical data or by using the slope of the line joining adjacent category limits on the ROC curve. For continuous test results, data need to be categorized into intervals for estimation of likelihood ratios, or ..
  68. pmc Urinary biomarkers in the early detection of acute kidney injury after cardiac surgery
    Won K Han
    Thomas Jefferson University Hospital, Department of Medicine, Jefferson Medical School, Philadelphia, Pennsylvania 19107, USA
    Clin J Am Soc Nephrol 4:873-82. 2009
    ..Receiver-operating characteristic curves were generated and the areas under the curve (AUCs) compared for performance of biomarkers in detection of postoperative AKI...
  69. pmc Screening for depression in medical settings with the Patient Health Questionnaire (PHQ): a diagnostic meta-analysis
    Simon Gilbody
    Department of Health Sciences, University of York, York, YO10 5DD, UK
    J Gen Intern Med 22:1596-602. 2007
    ..To summarize the psychometric properties of the PHQ2 and PHQ9 as screening instruments for depression...
  70. ncbi Diagnostic accuracy of adenosine deaminase in tuberculous pleurisy: a meta-analysis
    Qiu Li Liang
    Institute of Respiratory Diseases, First Affiliated Hospital, Guangxi Medical University, Nanning, 530021 Guangxi, People s Republic of China
    Respir Med 102:744-54. 2008
    ..We conducted a meta-analysis to determine the accuracy of ADA measurements in the diagnosis of tuberculous pleurisy...
  71. ncbi Summary receiver operating characteristic curve analysis techniques in the evaluation of diagnostic tests
    Catherine M Jones
    The National Heart and Lung Institute, Imperial College of Science, Technology, and Medicine, Department of Cardiothoracic Surgery, St Mary s Hospital, London, United Kingdom
    Ann Thorac Surg 79:16-20. 2005
    ..We use a practical approach to show how SROC analysis can be applied to meta-analysis of diagnostic accuracy by using a contrived dataset of studies on virtual bronchoscopy in the diagnosis of airway lesions...
  72. ncbi Body mass index, waist circumference, and clustering of cardiovascular disease risk factors in a biracial sample of children and adolescents
    Peter T Katzmarzyk
    School of Physical and Health Education and Department of Community Health and Epidemiology, Queen s University, Kingston, Ontario, Canada
    Pediatrics 114:e198-205. 2004
    ..To derive optimal body mass index (BMI) and waist circumference thresholds for children and adolescents, to predict risk factor clustering...
  73. ncbi Limitations of the odds ratio in gauging the performance of a diagnostic, prognostic, or screening marker
    Margaret Sullivan Pepe
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Am J Epidemiol 159:882-90. 2004
    ..In addition, the serious pitfalls of using more traditional methods based on parameters in logistic regression models are illustrated...
  74. ncbi Type 2 tasks in the theory of signal detectability: discrimination between correct and incorrect decisions
    Susan J Galvin
    Department of Psychology, University of Otago, Dunedin, New Zealand
    Psychon Bull Rev 10:843-76. 2003
    ..This curve can be compared with a theoretical ROC curve, which can be generated from overlapping probability functions conditional on the Type 1 events on an ..
  75. pmc Relating introspective accuracy to individual differences in brain structure
    Stephen M Fleming
    Wellcome Trust Centre for Neuroimaging, University College London, 12 Queen Square, London WC1N 3BG, UK
    Science 329:1541-3. 2010
    ..Our findings point to a focal neuroanatomical substrate for introspective ability, a substrate distinct from that supporting primary perception...
  76. pmc Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
    John B Harley
    Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, Oklahoma 73104, USA
    Nat Genet 40:204-10. 2008
    ..Our results show that numerous genes, some with known immune-related functions, predispose to SLE...
  77. ncbi Predicting the likelihood of carrying a BRCA1 or BRCA2 mutation: validation of BOADICEA, BRCAPRO, IBIS, Myriad and the Manchester scoring system using data from UK genetics clinics
    A C Antoniou
    Cancer Research UK, Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK
    J Med Genet 45:425-31. 2008
    ..Several algorithms that predict the likelihood of carrying a BRCA1 or a BRCA2 mutation are currently used in clinical practice to identify such individuals...
  78. ncbi A comparison between cystatin C, plasma creatinine and the Cockcroft and Gault formula for the estimation of glomerular filtration rate
    Frans J Hoek
    Academic Medical Center, Department of Clinical Chemistry, Room F1 219, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Nephrol Dial Transplant 18:2024-31. 2003
    ..No data are available, however, on the performance of cys C in follow-up of patients, compared with creatinine. Also, comparisons of cys C with the Cockcroft and Gault (C&G) formula for estimation of GFR are few...
  79. ncbi Maximum entropy modeling of short sequence motifs with applications to RNA splicing signals
    Gene Yeo
    Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue Building 68 223, Cambridge, MA 02319, USA
    J Comput Biol 11:377-94. 2004
    ..Our best models out-perform previous probabilistic models in the discrimination of human 5' (donor) and 3' (acceptor) splice sites from decoys. Finally, we discuss mechanistically motivated ways of comparing models...
  80. ncbi Detection of biomarkers with a multiplex quantitative proteomic platform in cerebrospinal fluid of patients with neurodegenerative disorders
    Fadi Abdi
    Applied Biosystems, Framingham, MA, USA
    J Alzheimers Dis 9:293-348. 2006
  81. ncbi Receiver-operating characteristic analysis for evaluating diagnostic tests and predictive models
    Kelly H Zou
    Children s Hospital Boston, Boston, MA, USA
    Circulation 115:654-7. 2007
  82. pmc Comparison of HIV-1 genotypic resistance test interpretation systems in predicting virological outcomes over time
    Dineke Frentz
    Virology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands
    PLoS ONE 5:e11505. 2010
    ..This study compares the ability of the most commonly used systems (ANRS, Rega, and Stanford's HIVdb) to predict virological outcome at 12, 24, and 48 weeks...
  83. ncbi Understanding receiver operating characteristic (ROC) curves
    Jerome Fan
    Division of Emergency Medicine, McMaster University, Hamilton, ON
    CJEM 8:19-20. 2006
  84. pmc Receiver operating characteristic (ROC) curve: practical review for radiologists
    Seong Ho Park
    Department of Radiology, Seoul National University College of Medicine and Institute of Radiation Medicine, SNUMRC, Seoul, Korea
    Korean J Radiol 5:11-8. 2004
    ..this analysis, such as smooth and empirical ROC curves, parametric and nonparametric methods, the area under the ROC curve and its 95% confidence interval, the sensitivity at a particular FPR, and the use of a partial area under the ..
  85. ncbi Urinary neutrophil gelatinase-associated lipocalin and acute kidney injury after cardiac surgery
    Gebhard Wagener
    Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032 3784, USA
    Am J Kidney Dis 52:425-33. 2008
    ..We report the association of urinary NGAL with indexes of intraoperative renal hypoperfusion (cardiopulmonary bypass time and aortic cross-clamp time) and acute kidney injury (AKI) after adult cardiac surgery...
  86. ncbi Clinical risk factors, DNA variants, and the development of type 2 diabetes
    Valeriya Lyssenko
    Department of Clinical Sciences, Lund University, Malmo, Sweden
    N Engl J Med 359:2220-32. 2008
    ..Type 2 diabetes mellitus is thought to develop from an interaction between environmental and genetic factors. We examined whether clinical or genetic factors or both could predict progression to diabetes in two prospective cohorts...
  87. ncbi Comparison of gadolinium-EOB-DTPA-enhanced and diffusion-weighted liver MRI for detection of small hepatic metastases
    Kotaro Shimada
    Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto, 606 8507, Japan
    Eur Radiol 20:2690-8. 2010
    ..To compare the accuracy of gadolinium ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MRI with that of diffusion-weighted MRI (DWI) in the detection of small hepatic metastases (2 cm or smaller)...
  88. ncbi A validated risk score for in-hospital mortality in patients with heart failure from the American Heart Association get with the guidelines program
    Pamela N Peterson
    Denver Health Medical Center, Denver, CO, USA
    Circ Cardiovasc Qual Outcomes 3:25-32. 2010
    ..Our objective was to derive and validate a risk score for in-hospital mortality in patients hospitalized with heart failure using American Heart Association Get With the Guidelines-Heart Failure (GWTG-HF) program data...
  89. ncbi Megakaryocyte potentiating factor as a tumor marker of malignant pleural mesothelioma: evaluation in comparison with mesothelin
    Kota Iwahori
    Department of Respiratory Medicine, Allergy, and Rheumatic Diseases, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Lung Cancer 62:45-54. 2008
    ..We developed a novel enzyme-linked immunosorbent assay (ELISA) system to compare the diagnostic efficacy of MPF and MSLN in MPM and control groups...
  90. pmc Relation between lymphopenia and bacteraemia in UK adults with medical emergencies
    D H Wyllie
    Nuffield Departments of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    J Clin Pathol 57:950-5. 2004
    ..To determine the relevance of lymphopenia to the diagnosis of bacteraemia in patients admitted with medical emergencies, relative to peripheral blood white cell count and neutrophilia...
  91. ncbi Circulating cell-free DNA in plasma of melanoma patients: qualitative and quantitative considerations
    Pamela Pinzani
    Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Clin Chim Acta 412:2141-5. 2011
    ..According to ROC curve analysis, the ratio 180/67 is the most suitable index to be used in cancer patient selection, even if the ..
  92. pmc Comparison of a novel multiple marker assay vs the Risk of Malignancy Index for the prediction of epithelial ovarian cancer in patients with a pelvic mass
    Richard G Moore
    Program in Women s Oncology, Department of Obstetrics and Gynecology, Women and Infants Hospital of Rhode Island, Warren Alpert Medical School, Brown University, Providence, RI, USA
    Am J Obstet Gynecol 203:228.e1-6. 2010
    ..We sought to compare the Risk of Malignancy Index (RMI) to the Risk of Ovarian Malignancy Algorithm (ROMA) to predict epithelial ovarian cancer (EOC) in women with a pelvic mass...
  93. pmc New models and online calculator for predicting non-sentinel lymph node status in sentinel lymph node positive breast cancer patients
    Holbrook E Kohrt
    Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA
    BMC Cancer 8:66. 2008
    ..Our goal was to develop new models to quantify the risk of NSLN metastasis in SLN-positive patients and to compare predictive capabilities to another widely used model...
  94. ncbi A novel set of DNA methylation markers in urine sediments for sensitive/specific detection of bladder cancer
    Jian Yu
    Cancer Genetics and Gene Therapy Program, The State Key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai Jiao Tong University, Shanghai, China
    Clin Cancer Res 13:7296-304. 2007
    ..This study aims to provide a better set of DNA methylation markers in urine sediments for sensitive and specific detection of bladder cancer...
  95. ncbi Use of PCR for diagnosis of invasive aspergillosis: systematic review and meta-analysis
    Carlo Mengoli
    Department of Histology, Microbiology, and Medical Biotechnology, University of Padua, Padua, Italy
    Lancet Infect Dis 9:89-96. 2009
    ..Efforts are underway to devise a standard for Aspergillus sp PCR for screening, which will help enable formal validation of PCR and estimate its use in patients most likely to benefit...
  96. ncbi Neck Disability Index, short form-36 physical component summary, and pain scales for neck and arm pain: the minimum clinically important difference and substantial clinical benefit after cervical spine fusion
    Leah Y Carreon
    Norton Leatherman Spine Center, 210 East Gray St, Suite 900, Louisville, KY 40202, USA
    Spine J 10:469-74. 2010
    ..The minimum clinically important difference (MCID) is a threshold of improvement that is clinically relevant to the patient. However, the true goal is to provide the patient with a substantial clinical benefit (SCB)...
  97. ncbi Cystatin C: an improved estimator of glomerular filtration rate?
    Omar F Laterza
    Washington University School of Medicine, Department of Pathology and Immunology, Division of Laboratory Medicine, Box 8118, 660 S Euclid Ave, St Louis, MO 63110, USA
    Clin Chem 48:699-707. 2002
    ..The purpose of this review is to critically review the potential utility of cystatin C (CysC), especially in patient populations in which CysC may have an advantage over routinely used endogenous markers of GFR...
  98. ncbi Comparison and validation of simple noninvasive tests for prediction of fibrosis in chronic hepatitis C
    Carolin Lackner
    Department of Pathology, Medical University Graz, Graz, Austria
    Hepatology 41:1376-82. 2005
    ..of CDS, AP index, APRI, and platelet count for prediction of significant fibrosis (F3-F6) (area under the ROC curve [AUROC], 0.71, 0.74, 0.80, and 0...
  99. ncbi Noninvasive methods to assess liver disease in patients with hepatitis B or C
    Laurent Castera
    Department of Hepatology, Hopital Beaujon, Assistance Publique Hopitaux de Paris, INSERM U773 CRB3, Universite Denis Diderot Paris 7, Clichy, France
    Gastroenterology 142:1293-1302.e4. 2012
    ..We review the advantages and limitations of the noninvasive methods used to manage patients with chronic viral hepatitis B or C infection...
  100. ncbi Combining the P300-complex trial-based concealed information test and the reaction time-based autobiographical implicit association test in concealed memory detection
    Xiaoqing Hu
    Department of Psychology, Northwestern University, Evanston, Illinois 60208, USA
    Psychophysiology 49:1090-100. 2012
    ..The indicators from the RT-aIAT and P300-CIT were uncorrelated, thus combining P300-CIT and aIAT data further increased the efficiency of memory detection...
  101. ncbi A blood-based biomarker panel for stratifying current risk for colorectal cancer
    Kenneth Wayne Marshall
    GeneNews Ltd, Richmond Hill, Ontario, Canada
    Int J Cancer 126:1177-86. 2010
    ..Across the continuous spectrum of risk as defined by the current relative risk scale, it is possible to identify clinically meaningful reference points that can assist patients and physicians in CRC screening decision making...

Research Grants63

  1. Cardiac Troponin Testing for Myocardial Infarction
    Fred Apple; Fiscal Year: 2001
    ..Clinical performance of each assay (defined by ROC curve analyses) will be assessed using each cardiac maker assay for detection of AMI, compared to the ICD-9-CM ..
  2. Arm Exercise versus Other Stress Test Modalities for Clinical Outcome Prediction
    WADE HAMPTON MARTIN; Fiscal Year: 2013
  3. Prognostic &Therapeutic Implications of Breathing Patterns in Acute Lung Injury
    FRANK JOSEPH JACONO; Fiscal Year: 2013
    ..While initially applied in the ICU, these approaches will be easily applied in other settings identifying patients in need of a higher level of care or more intensive therapy. ..
  4. Beta Camera and Laparoscopic Probe for Surgical Cancer Removal.
    FARHAD DAGHIGHIAN; Fiscal Year: 2010
    ..The ROC analysis of the beta camera with visual detection of the surgeons will show if beta cameras added can help increase the rate of margin detection. ..
  5. Developing an Automated Symptom Monitoring Device for Adolescents with Asthma
    Hyekyun Rhee; Fiscal Year: 2012
  6. Detecting early disease using variability in markers under informative censoring
    Cuiling Wang; Fiscal Year: 2013
    ..In addition, these approaches will have broad applicability given that all longitudinal aging studies share similar heterogeneous variance and informative censoring issues. ..
  7. Drug Screen for Primary Care Patients
    Quyen Tiet; Fiscal Year: 2013
    ..using the receiver operating characteristic (ROC), multivariate logistic regression analyses, and area under the ROC curve (AUC) analytical techniques will be conducted to identify the best screening instrument...
  8. Genetic Risk Prediction in Primary Care
    Swati Biswas; Fiscal Year: 2013
    ..of their sensitivities, specificities, and other related statistics at a range of cutoffs, and area under the ROC curve (AUC)...
  9. Analysis of the Data from Vision in Preschoolers (VIP) Study
    Gui Shuang Ying; Fiscal Year: 2010
    ..The very large sample size (N=4,040), as well as the experience and high productivity of the VIP Study Group, support the feasibility and likelihood of high yield of the proposed project. ..
  10. Quantitative Subharmonic Breast Imaging
    Flemming Forsberg; Fiscal Year: 2013
  11. Axial Shear Strain Elastography In Benign and Malignant Breast Disease
    Jonathan Ophir; Fiscal Year: 2012
  12. Improved DBM ROC Methods for Diagnostic Radiology
    KEVIN STALEY BERBAUM; Fiscal Year: 2010 abnormal cases is close to one or zero;(3) provide a validated and easy-to-use ordinal regression option for ROC curve fitting within our major DBM MRMC method that offers familiar and interpretable ROC-style results;(4) extend DBM ..
    Michael Phillips; Fiscal Year: 2009
    ..Early, safe and cost-effective detection of lung cancer could potentially reduce the number of lives lost to the disease. ..
  14. Computer-Aided Diagnosis of Breast Lesions in Mammograms
    Yulei Jiang; Fiscal Year: 2013
    ..abstract_text> ..
  15. Healing of Segmental Defects of Bone by Gene Transfer
    Christopher H Evans; Fiscal Year: 2013
    ..Because the technology uses existing hardware, clinical translation should be straightforward. ..
    Wishwa Kapoor; Fiscal Year: 1991
    ..specificity of the previously derived models on the new group of patients, 2) a comparison of the area under the ROC curve derived from the derivation set to the area from the validation set, and 3) calculation of the likelihood ratios ..
    Jane Newburger; Fiscal Year: 1992
    ..We will evaluate models using the area under the ROC curve, a simultaneous measure of sensitivity and specificity; the R2 statistic, a measure of overall model fit; and ..
  18. Prostate-cancer Imaging by Combined Ultrasound and Magnetic-resonance Parameters
    ERNEST JOSEPH FELEPPA; Fiscal Year: 2013
    ..Successfully generating reliable prostate TTIs based on combined US and MR parameters will represent a quantum advance in PCa management by enabling significant improvements in the diagnosis and treatment of PCa. ..
  19. Quantitative diagnosis of breast cancer with ultrasound
    Chandra M Sehgal; Fiscal Year: 2013
    ..This application introduces a new paradigm that will use quantitative methods to differentiate malignant and benign breast masses. If successful, the proposed research could reduce the number of false positive or unnecessary biopsies. ..
    Andriy Bandos; Fiscal Year: 2013
    ..One of the more clinically relevant methods of ROC analysis is based on the part of the ROC curve which describes operating characteristics that are expected to be actually observable in clinical practice...
    John Boone; Fiscal Year: 1993
    ..The comprehensive approach to digital chest imaging proposed here should increase the effectiveness of chest radiography, by increasing the sensitivity and specificity to pulmonary nodules and other chest pathologies...
  22. Chaos in Human Phonation and Its Measurement
    Jack Jiang; Fiscal Year: 2007
    ..The sensitivity and specificity of nonlinear dynamic parameters in distinguishing normal from pathologic voices will be assessed based on the received operating characteristic (ROC) analysis. [unreadable] [unreadable]..
  23. Semantic Guidance of Visual Attention
    Marc Pomplun; Fiscal Year: 2013
    ..The resulting two-level attentional control model will advance the field by helping researchers to form a more comprehensive view of visual attention in real-world scenes. ..
    RICHARD SWENSON; Fiscal Year: 1980
    ..The benefits and costs of this system was analyzed in order to assess, in a real-life setting, the perceptual process in radiology as practiced by those in training. ..
  25. Accurate Models for Predicting Radiation-Induced Injury
    Shiva Das; Fiscal Year: 2009
    ..They will be made publicly available via the Internet. The overall impact of this work will be to facilitate significant reduction in thoracic radiotherapy-induced injury via accurate prediction. ..
    Kevin Berbaum; Fiscal Year: 2001
    ..This reduction in error could be most significant with increased image interpretation by non-radiologists, who, being principally driven by their clinical suspicion, are more susceptible to errors involving unanticipated abnormalities. ..
  27. Malnutrition in Childhood Chronic Renal Failure
    Bethany Foster; Fiscal Year: 2003
    ..Logistic regression and ROC analysis will be used to provide a quantitative comparison of each renal function measure's ability to discriminate between patients with and without malnutrition. ..
    Martin Resnick; Fiscal Year: 1992
    Benjamin Tsui; Fiscal Year: 2000
    ..The applicants projected that the research could significantly improve tumor imaging using dual camera ECT systems operated in both single photon and coincidence detection modes. ..
    Kunio Doi; Fiscal Year: 1992
    ..The established investigators in the Departments of Radiology, Radiation Oncology, and Cardiology would greatly benefit from accessibility of the high-resolution image processing workstation, which currently is not available...
    Rex Chisholm; Fiscal Year: 2002
    ..Plasma MMP-9 levels will be followed in a subgroup of patients longitudinally to predict rapid expansion. Additionally, plasma MMP-9 levels will be followed after open and endovascular repair. ..
  32. Quantitative RNFL Assessment for Glaucoma Diagnosis
    HENRY GRADY RYLANDER; Fiscal Year: 2010
    ..4. Using ROC analysis, formulate and test a feature set and classifier based on RNFL thickness (ZKNFL), retardation (SRNFL), and birefringence (AnRNFL) for discriminating between normal and glaucomatous human eyes. ..
    Susan Norton; Fiscal Year: 2000
    ..The influence of age and medical status on the performance of TOAE, ADP and ABR in identifying peripheral hearing impairment, as well as the cost of implementation and cost-effectiveness will also be evaluated. ..
    Yuan Hsiang Chang; Fiscal Year: 2000
    ..Receiver- operating characteristics (ROC) analysis will also be performed to evaluate the scheme performance using a clinical database that was never used during the scheme development and optimization. ..
    CHARLES METZ; Fiscal Year: 2000 the applicants for fitting ROC curves and for testing the statistical significance of differences between ROC curve estimates; (2) developing and evaluating new algorithms for ROC curve-Fitting and statistical testing, based on ..
    Ennapadam Venkatraman; Fiscal Year: 2001
    ..are in a rating scale (for example radiologic data) and study the effect of the models-used to generate the ROC curve from the discrete points on the rating scale...
    ALICIA TOLEDANO; Fiscal Year: 2002
    ..used in this research will employ a multiplicative predicator such that both the height and summetry of the ROC curve can depend on characteristics of cases and/or readers...
    John Engel; Fiscal Year: 1993
    ..The resulting software product will be available as a diagnostic tool which can be operated on standard microcomputers with no additional hardware requirements...
  39. Smart Phantom for Characterizing fMRI Informatics Tools
    Qun Zhao; Fiscal Year: 2004
    ..MRI reconstruction techniques will be compared to find an optimal way to acquire and process data. And last, validation and characterization will be performed using functional imaging data acquired from human subjects. ..
    Dev Chakraborty; Fiscal Year: 2000
    ..Analysis of this experiment yields the area under the Differential ROC curve (!ROC)...
  41. Serum C-tau Precition of Brain Damage in Mild TBI
    Frank Zemlan; Fiscal Year: 2003
    ..Similar analysis as for Specific Aim 1 but restricted to patients with no CT abnormality which is projected to be about 85% to 90% of all patients (N = approximately 70). ..
  42. Estimating Neural Network Precision for Cancer Diagnosis
    Yulei Jiang; Fiscal Year: 2003
    PHILIP SOMERVELL; Fiscal Year: 1990
    ..The dataset represents a unique opportunity to analyze the performance of two screening measures in relation to a state-of-the-art diagnostic interview, in a sample from a particular tribal group in one American Indian community...
  44. Home Sensor Data Fusion to Support Aging in Place
    Jane Jorgensen; Fiscal Year: 2004
    ..assessment of the models, including evaluation of models by mutual information, log probability scores and ROC curve analysis...
    Michael Vannier; Fiscal Year: 1991
    ..We hypothesize that 3DCT is significantly better than other imaging systems for the delineation of craniosynostosis and that for 3DCT the importance of observer experience will be significantly less...
  46. Nine mega-pixel digital mammography display workstation
    Jasjit Suri; Fiscal Year: 2003
    ..The measured outcomes will be area under the ROC curve, sensitivity, specificity, and interpretation time.
    Maria Kallergi; Fiscal Year: 2000
    David Gur; Fiscal Year: 1990
    ..We expect these investigations to yield specific recommendations for display requirements of PACS in the radiology environment...
    IZTOK KOREN; Fiscal Year: 1999
    ..The technology transfer process is simplified by the fact that AMY is essentially a software enhancement to an OEM's existing digital mammography systems. ..
  50. Neural Network Prediction of Prostate Cancer Progression
    Yulei Jiang; Fiscal Year: 2003
    ..abstract_text> ..
  51. Doppler Vascularity/Sonography--Breast Cancer Diagnosis
    Chandra Sehgal; Fiscal Year: 2005
    ..An integrated approach in which one mode represents tissue property and the other its function will result in a systematic and comprehensive diagnosis of breast cancers. ..
    Harold Kundel; Fiscal Year: 1980
    ..The results of these experiments will clarify the role of perceptual processes in film reading and suggest ways of reducing errors thus improving diagnostic accuracy...
    BRIAN CRAINE; Fiscal Year: 1993
    ..In addition, the design for the integration of this optical component as a convenient improvement of a disposable vaginal speculum will be completed...
  54. Quantitative Image Quality for Optimization of MRI
    David Wilson; Fiscal Year: 2007
    ..When this research is successfully completed, we will have established useful tools for evaluating and optimizing the almost unlimited number of MR imaging methods. ..
    Andrew Karellas; Fiscal Year: 1999
  56. Three-Class ROC Analysis for Task-Based Medical Image Quality Assessment
    Xin He; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
    Sheila Moore; Fiscal Year: 1993
    ..Direct comparative study of the imaging modality with the pathologic specimen as well as ROC analysis of specific parameters will be made...
    Dev Chakraborty; Fiscal Year: 2002
    ..Also to be generated are iso-contour plots of the effects of common workstation variables on image quality in both tasks. This will allow digital mammography workstations to be more intelligently used. ..
    Dev Chakraborty; Fiscal Year: 2003
    ..Also to be generated are iso-contour plots of the effects of common workstation variables on image quality in both tasks. This will allow digital mammography workstations to be more intelligently used. ..
  60. Causal Analysis of Encouragement Design Studies
    Xiao Hua Zhou; Fiscal Year: 2004
    ..In this proposal, we will develop a general statistical methodology for causal treatment analysis of the randomized EDS when data have a complicated structure. ..
  61. Digital Mammography: Advanced Computer-Aided Breast Can*
    Heang Ping Chan; Fiscal Year: 2007
    ..abstract_text> ..
  62. Considerations of covariates in biomarker studies
    Margaret S Pepe; Fiscal Year: 2010
    ..We will address covariate adjustment in the evaluation of a biomarker's performance with the ROC curve (Aim 1), in making comparisons between biomarkers (Aim 2(i)) and in evaluating variations in the performance of ..
  63. Statistical Methods in Diagnostic Medicine
    Xiao Hua Zhou; Fiscal Year: 2007
    ..Finally, we will develop general group sequential designs for comparative ROC studies using nonparametrically estimated ROC curves. [unreadable] [unreadable]..