least squares analysis


Summary: A principle of estimation in which the estimates of a set of parameters in a statistical model are those quantities minimizing the sum of squared differences between the observed values of a dependent variable and the values predicted by the model.

Top Publications

  1. ncbi Chemometrics in metabonomics
    Johan Trygg
    Research Group for Chemometrics, Institute of Chemistry, Umea University, Sweden
    J Proteome Res 6:469-79. 2007
  2. ncbi Statistical characterisation of bacterial wild-type MIC value distributions and the determination of epidemiological cut-off values
    J Turnidge
    Division of Laboratory Medicine, Women s and Children s Hospital, North Adelaide, South Australia 5006, Australia
    Clin Microbiol Infect 12:418-25. 2006
  3. ncbi Partial least squares: a versatile tool for the analysis of high-dimensional genomic data
    Anne Laure Boulesteix
    Department of Medical Statistics and Epidemiology, Technical University of Munich, Ismaningerstrasse 22, D 81675 Munich, Germany
    Brief Bioinform 8:32-44. 2007
  4. pmc Prediction of total genetic value using genome-wide dense marker maps
    T H Meuwissen
    Research Institute of Animal Science and Health, 8200 AB Lelystad, The Netherlands
    Genetics 157:1819-29. 2001
  5. ncbi An alternating least squares approach to inferring phylogenies from pairwise distances
    J Felsenstein
    Department of Genetics, University of Washington, Box 357360, Seattle, Washington 98195 7360, USA
    Syst Biol 46:101-11. 1997
  6. ncbi Using chemometrics for navigating in the large data sets of genomics, proteomics, and metabonomics (gpm)
    Lennart Eriksson
    Umetrics AB, POB 7960, 907 19, Umea, Sweden
    Anal Bioanal Chem 380:419-29. 2004
  7. ncbi Toxicological effects of cinnabar in rats by NMR-based metabolic profiling of urine and serum
    Lai Wei
    Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, PR China
    Toxicol Appl Pharmacol 227:417-29. 2008
  8. ncbi Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics
    Joanne T Brindle
    Biological Chemistry, Biomedical Sciences Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London, UK
    Nat Med 8:1439-44. 2002
  9. ncbi Human craniofacial sphericity: a simultaneous analysis of frontal and lateral cephalograms of a Japanese population using geometric morphometrics and partial least squares analysis
    Markus Bastir
    Department of Paleobiology, Museo Nacional de Ciencias Naturales CSIC, c Jose Gutierrez Abascal, 2, 28006 Madrid, Spain
    Arch Oral Biol 53:295-303. 2008
  10. ncbi A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis
    Kevin A Janes
    Biological Engineering Division, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 310:1646-53. 2005

Detail Information

Publications287 found, 100 shown here

  1. ncbi Chemometrics in metabonomics
    Johan Trygg
    Research Group for Chemometrics, Institute of Chemistry, Umea University, Sweden
    J Proteome Res 6:469-79. 2007
    ..This is illustrated by examples from the literature...
  2. ncbi Statistical characterisation of bacterial wild-type MIC value distributions and the determination of epidemiological cut-off values
    J Turnidge
    Division of Laboratory Medicine, Women s and Children s Hospital, North Adelaide, South Australia 5006, Australia
    Clin Microbiol Infect 12:418-25. 2006
    ..5% of MIC values fall within the cut-off value range. Non-linear regression fitting to a cumulative log-normal distribution is a novel and effective method for modelling MIC distributions and quantifying wild-type MIC ranges...
  3. ncbi Partial least squares: a versatile tool for the analysis of high-dimensional genomic data
    Anne Laure Boulesteix
    Department of Medical Statistics and Epidemiology, Technical University of Munich, Ismaningerstrasse 22, D 81675 Munich, Germany
    Brief Bioinform 8:32-44. 2007
    ..g. tumor classification from transcriptome data, identification of relevant genes, survival analysis and modeling of gene networks and transcription factor activities...
  4. pmc Prediction of total genetic value using genome-wide dense marker maps
    T H Meuwissen
    Research Institute of Animal Science and Health, 8200 AB Lelystad, The Netherlands
    Genetics 157:1819-29. 2001
    ..It was concluded that selection on genetic values predicted from markers could substantially increase the rate of genetic gain in animals and plants, especially if combined with reproductive techniques to shorten the generation interval...
  5. ncbi An alternating least squares approach to inferring phylogenies from pairwise distances
    J Felsenstein
    Department of Genetics, University of Washington, Box 357360, Seattle, Washington 98195 7360, USA
    Syst Biol 46:101-11. 1997
    ..The relationship of this method to the neighbor-joining method is also discussed...
  6. ncbi Using chemometrics for navigating in the large data sets of genomics, proteomics, and metabonomics (gpm)
    Lennart Eriksson
    Umetrics AB, POB 7960, 907 19, Umea, Sweden
    Anal Bioanal Chem 380:419-29. 2004
    ..The third and last data set describes sequence-function classification studies in a set of G-protein-coupled receptors using hierarchical PCA...
  7. ncbi Toxicological effects of cinnabar in rats by NMR-based metabolic profiling of urine and serum
    Lai Wei
    Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, PR China
    Toxicol Appl Pharmacol 227:417-29. 2008
    ..This work illustrated the high reliability of NMR-based metabolomic approach on the study of the biochemical effects induced by traditional Chinese medicine...
  8. ncbi Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics
    Joanne T Brindle
    Biological Chemistry, Biomedical Sciences Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London, UK
    Nat Med 8:1439-44. 2002
  9. ncbi Human craniofacial sphericity: a simultaneous analysis of frontal and lateral cephalograms of a Japanese population using geometric morphometrics and partial least squares analysis
    Markus Bastir
    Department of Paleobiology, Museo Nacional de Ciencias Naturales CSIC, c Jose Gutierrez Abascal, 2, 28006 Madrid, Spain
    Arch Oral Biol 53:295-303. 2008
    ..The aim of this paper was to test Enlows morphological predictions of the "balloon model" of cranial head form patterns. This model predicts specific suites of morphological features in relation to basicranial flexure and skull globularity...
  10. ncbi A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis
    Kevin A Janes
    Biological Engineering Division, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 310:1646-53. 2005
    ..Projection along these axes captures the entire measured apoptotic network, suggesting that cell survival is determined by signaling through this canonical basis set...
  11. ncbi Partial least squares proportional hazard regression for application to DNA microarray survival data
    Danh V Nguyen
    Department of Statistics, Texas A and M University, College Station, TX 77843, USA
    Bioinformatics 18:1625-32. 2002
    ..We consider here the case that the number of covariates, p, exceeds the number of samples, N, a setting typical of gene expression data from DNA microarrays...
  12. ncbi Fast exact leave-one-out cross-validation of sparse least-squares support vector machines
    Gavin C Cawley
    School of Computing Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Neural Netw 17:1467-75. 2004
    ..For clarity the exposition concentrates on sparse least-squares support vector machines in the context of non-linear regression, but is equally applicable in a pattern recognition setting...
  13. pmc Interrupted time-series analysis of regulations to reduce paracetamol (acetaminophen) poisoning
    Oliver W Morgan
    Department of Primary Care and Social Medicine, Imperial College London, United Kingdom
    PLoS Med 4:e105. 2007
  14. ncbi Pharmacophore identification and validation study of CK2 inhibitors using CoMFA/CoMSIA
    Mohammad Neaz Morshed
    Korea Institute of Science and Technology, Seoul, South Korea
    Chem Biol Drug Des 74:148-58. 2009
    ..The overall study implies that a highly positive and bulky group with H-bond donating property is desirable around the nitrogen atom adjacent to the pyrrolidine ring...
  15. pmc Empirical Bayes hierarchical models for regularizing maximum likelihood estimation in the matrix Gaussian Procrustes problem
    Douglas L Theobald
    Department of Chemistry and Biochemistry, UCB 215, University of Colorado, Boulder, CO 80309, USA
    Proc Natl Acad Sci U S A 103:18521-7. 2006
    ..Our analysis generalizes, simplifies, and extends results from previous discussions of the ML Procrustes problem. An iterative algorithm is presented for the simultaneous, numerical determination of the ML solutions...
  16. ncbi Identification of small scale biochemical networks based on general type system perturbations
    Henning Schmidt
    Signals, Sensors and Systems, Royal Institute of Technology KTH, Stockholm, Sweden
    FEBS J 272:2141-51. 2005
    ..We demonstrate herein the performance of the method on two small-scale in silico genetic networks...
  17. ncbi The association of bacterial adhesion with dental caries
    C Stenudd
    Department of Odontology/Cariology, , Sweden
    J Dent Res 80:2005-10. 2001
    ..Non-Db phenotypes (i.e., acidic PRP-1 and PRP-2 variants) coincided with both low caries experience and S. mutans, but high A. naeslundii, adhesion. Thus, bacterial adhesion may modulate susceptibility and resistance to dental caries...
  18. ncbi Partial least squares analysis of neuroimaging data: applications and advances
    Anthony Randal McIntosh
    Rotman Research Institute of Baycrest Centre, University of Toronto, Toronto, Ontario, Canada M6A 2E1
    Neuroimage 23:S250-63. 2004
    ..We further discuss its role as an important tool in a pluralistic analytic approach to neuroimaging...
  19. pmc An adaptive prediction and detection algorithm for multistream syndromic surveillance
    Amir Homayoon Najmi
    National Security Technology Department, The Johns Hopkins University Applied Physics Laboratory, Laurel, MD 20723 6099, USA
    BMC Med Inform Decis Mak 5:33. 2005
    ..In this paper we extend our results to predict clinical data multiple steps ahead using OTC sales as well as the clinical data itself...
  20. pmc Integrative analysis of genome-scale data by using pseudoinverse projection predicts novel correlation between DNA replication and RNA transcription
    Orly Alter
    Department of Biomedical Engineering and Institute for Cellular and Molecular Biology, University of Texas, Austin, TX 78712, USA
    Proc Natl Acad Sci U S A 101:16577-82. 2004
    ..Novel correlation between DNA replication initiation and RNA transcription during the yeast cell cycle, which might be due to a previously unknown mechanism of regulation, is predicted...
  21. pmc Metabolic profiles to define the genome: can we hear the phenotypes?
    Julian L Griffin
    Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK
    Philos Trans R Soc Lond B Biol Sci 359:857-71. 2004
  22. ncbi Improved approach for proteochemometrics modeling: application to organic compound--amine G protein-coupled receptor interactions
    Maris Lapinsh
    Department of Pharmaceutical Biosciences, Uppsala University Box 591 BMC, SE 751 24 Uppsala, Sweden
    Bioinformatics 21:4289-96. 2005
    ..We have here customized it for analysis of large datasets and evaluated it for the modeling of the interaction of psychoactive organic amines with all the five known families of amine G protein-coupled receptors (GPCRs)...
  23. pmc Estimation of hospital emergency room data using OTC pharmaceutical sales and least mean square filters
    A H Najmi
    National Securit Technology Department, The Johns Hopkins University, Applied Physics Laboratory, Laurel, MD 20723 6099, USA
    BMC Med Inform Decis Mak 4:5. 2004
  24. ncbi Theoretical foundation of the balanced minimum evolution method of phylogenetic inference and its relationship to weighted least-squares tree fitting
    Richard Desper
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA
    Mol Biol Evol 21:587-98. 2004
    ..Interestingly, the covarion parameter has little effect on the tree quality for any of the algorithms. FASTME is freely available on the web...
  25. ncbi Detection of DNA copy number alterations using penalized least squares regression
    Tao Huang
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA
    Bioinformatics 21:3811-7. 2005
    ..In addition, we use a stationary bootstrap approach to estimate the statistical significance and false discovery rate...
  26. pmc Gene selection algorithms for microarray data based on least squares support vector machine
    E Ke Tang
    School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore
    BMC Bioinformatics 7:95. 2006
    ..It is not only difficult but also unnecessary to conduct the discriminant analysis with all the genes. Hence, gene selection is usually performed to select important genes...
  27. ncbi Missing value estimation for DNA microarray gene expression data: local least squares imputation
    Hyunsoo Kim
    Department of Computer Science and Engineering, University of Minnesota Twin Cities, 200 Union Street S E, Minneapolis, MN 55455, USA
    Bioinformatics 21:187-98. 2005
  28. ncbi Iron-induced oxidative stress in a macrophyte: a chemometric approach
    Sarita Sinha
    Ecotoxicology and Bioremediation Group, National Botanical Research Institute, Rana Pratap Marg, Lucknow 226 001, India
    Ecotoxicol Environ Saf 72:585-95. 2009
    ..MDA and NP-SH were identified as most pronounced variables in plant during the highest exposure time. The chemometric approach allowed for the interpretation of the induced biochemical changes in plant tissues exposed to iron...
  29. ncbi Tumor classification by partial least squares using microarray gene expression data
    Danh V Nguyen
    Center for Image Processing and Integrated Computing, University of California, Davis, CA 95616, USA
    Bioinformatics 18:39-50. 2002
    ..Modification of existing statistical methodologies or development of new methodologies is needed for the analysis of microarray data...
  30. ncbi Diagnosis of breast cancer using diffuse reflectance spectroscopy: Comparison of a Monte Carlo versus partial least squares analysis based feature extraction technique
    Changfang Zhu
    Department of Electrical and Computer Engineering, University of Wisconsin, Madison, Wisconsin 53705, USA
    Lasers Surg Med 38:714-24. 2006
    ..A physical model (Monte Carlo inverse model) and an empirical model (partial least squares analysis) based approach, were compared for extracting diagnostic features from the diffuse reflectance spectra.
  31. ncbi Exploring relationships in gene expressions: a partial least squares approach
    S Datta
    Department of Statistics and Mathematics, Georgia State University, Atlanta 30303, USA
    Gene Expr 9:249-55. 2001
    ..We show that this method can identify established gene relationships; we argue that it can be an exploratory tool for identifying potential gene relationships requiring further biological investigation...
  32. ncbi Multi-class cancer classification via partial least squares with gene expression profiles
    Danh V Nguyen
    Department of Statistics, Texas A and M University, College Station, TX 77843, USA
    Bioinformatics 18:1216-26. 2002
    ..The need for multi-class discrimination methodologies is apparent in many microarray experiments where various cancer types are considered simultaneously...
  33. ncbi Quantitative trait loci mapping for meat quality and muscle fiber traits in a Japanese wild boar x Large White intercross
    M Nii
    Livestock Research Institute, Tokushima Agriculture, Forestry and Fisheries Technology Center, Anan, Tokushima 774 0047, Japan
    J Anim Sci 83:308-15. 2005
    ..In five QTL located on SSC2, SSC6, and SSC14, each wild boar allele had the effect of increasing types I and IIA muscle fibers and decreasing type IIB muscle fibers. These effects are expected to improve meat quality...
  34. ncbi Confidence regions and hypothesis tests for topologies using generalized least squares
    Edward Susko
    Department of Mathematics and Statistics, Dalhousie University, Halifax, Nova Scotia
    Mol Biol Evol 20:862-8. 2003
    ..Assuming the model used to construct the distances is correct, the coverage probabilities are correct with large numbers of sites...
  35. ncbi Dimension reduction for classification with gene expression microarray data
    Jian J Dai
    University of California, Davis, USA
    Stat Appl Genet Mol Biol 5:Article6. 2006
    ..A five-step assessment procedure is designed for the purpose. Predictive accuracy and computational efficiency of the methods are examined. Two gene expression data sets for tumor classification are used in the study...
  36. ncbi Patient-reported outcomes helped predict survival in multiple myeloma using partial least squares analysis
    Muriel Viala
    Mapi Values, Lyon, France
    J Clin Epidemiol 60:670-679. 2007
  37. ncbi Cue-signal-response analysis of TNF-induced apoptosis by partial least squares regression of dynamic multivariate data
    Kevin A Janes
    Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Comput Biol 11:544-61. 2004
    ..Importantly, informative protein predictors of cell responses are always multivariate, demonstrating the multicomponent nature of the decision process...
  38. ncbi A two-stage discrimination of cardiac arrhythmias using a total least squares-based prony modeling algorithm
    S W Chen
    Department of Electronic Engineering, Chang Gung University, Tao Yuan, Taiwan
    IEEE Trans Biomed Eng 47:1317-27. 2000
    ..24%, 96.00%, 97.78%). A data decimation process is also introduced in the novel method to enhance the computational efficiency, resulting in a significant reduction in the time required for generating the feature values...
  39. ncbi Autocorrelation of molecular electrostatic potential surface properties combined with partial least squares analysis as new strategy for the prediction of the activity of human A(3) adenosine receptor antagonists
    Stefano Moro
    Molecular Modeling Section, Dipartimento di Scienze Farmaceutiche, Universita di Padova, Via Marzolo 5, I 35131 Padova, Italy
    J Med Chem 48:5698-704. 2005
    ..81) and prediction capability (r(pred) = 0.82). The proposed MEP/PLS approach can be considered as an alternative hit identification tool in virtual screening applications...
  40. pmc Testing the robustness of the new Haseman-Elston quantitative-trait loci-mapping procedure
    D B Allison
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA
    Am J Hum Genet 67:249-52. 2000
    ..for the ML approach (i.e., 100 pairs; high residual sibling correlation). Results showed that, when marked nonnormality is present, the NHE can be used without severe type I error-rate inflation, even at very small alpha levels...
  41. ncbi Fourier transform infrared-attenuated total reflection nitrate determination of soil pastes using principal component regression, partial least squares, and cross-correlation
    Raphael Linker
    Faculty of Civil and Environmental Engineering, Lowdermilk Division of Agricultural Engineering, Technion Israel Institute of Technology, Haifa, Israel, 32000
    Appl Spectrosc 58:516-20. 2004
    ..In this case, the best results are obtained using PLS, followed by PCR, while cross-correlation with reference libraries leads to poorer results...
  42. ncbi Signal LMMSE estimation from multiple samples in MRI and DT-MRI
    S Aja-Fernandez
    LPI, ETSI Telecomunicacion, Universidad de Valladolid
    Med Image Comput Comput Assist Interv 10:368-75. 2007
    ..This method gives a closed-form analytical solution that takes into account the probability distribution of the data as well as the existing level of noise, showing a better performance than methods such as the average or the median...
  43. ncbi Penalized discriminant methods for the classification of tumors from gene expression data
    Debashis Ghosh
    Department of Biostatistics, University of Michigan, 1420 Washington Heights, Ann Arbor, Michigan 48105, USA
    Biometrics 59:992-1000. 2003
    ..We also develop a procedure for ranking genes based on the fitted regression models. The proposed methodologies are applied to two microarray studies in cancer...
  44. ncbi Multiresolution moment filters: theory and applications
    Michael Sühling
    Biomedical Imaging Group, Swiss Federal Institute of Technology, Lausanne EPFL, CH 1015 Lausanne, Switzerland
    IEEE Trans Image Process 13:484-95. 2004
    ..The third is a multiscale optical-flow algorithm that uses a local affine model for the motion field, extending the Lucas-Kanade optical-flow method. The results obtained in all cases are promising...
  45. ncbi Determination of pesticides and metabolites in wine by high performance liquid chromatography and second-order calibration methods
    Jez Willian B Braga
    Universidade Estadual de Campinas, Instituto de Quimica, C P 6154, CEP 13084 971, Campinas SP, Brazil
    J Chromatogr A 1148:200-10. 2007
    ..Relative errors of prediction lower than 10% for all compounds were obtained, indicating that the methodology employing HLPC-DAD and second-order calibration can handle complex analytical systems...
  46. ncbi Multi-class tumor classification by discriminant partial least squares using microarray gene expression data and assessment of classification models
    Yongxi Tan
    Burns and Allen Research Institute Microarray Core, Cedars Sinai Medical Center, David Geffen School of Medicine, UCLA, Los Angeles, CA 90048, USA
    Comput Biol Chem 28:235-44. 2004
  47. ncbi Pure component selectivity analysis of multivariate calibration models from near-infrared spectra
    Mark A Arnold
    Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA
    Anal Chem 76:2583-90. 2004
    ..The proposed procedure demonstrates conclusively that no component of the sucrose or maltose spectrum contributes to the selective measurement of glucose. Analogous conclusions are possible for the sucrose and maltose calibration models...
  48. ncbi A nonlinear least square technique for simultaneous image registration and super-resolution
    Yu He
    School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore 639798
    IEEE Trans Image Process 16:2830-41. 2007
    ..An iterative scheme is developed to solve the arising nonlinear least squares problem. Experimental results show that the proposed method is effective in performing image registration and SR for simulated as well as real-life images...
  49. ncbi Megavariate analysis of hierarchical QSAR data
    Lennart Eriksson
    Umetrics AB, POB 7960, 907 19 Umeå, Sweden
    J Comput Aided Mol Des 16:711-26. 2002
    ..Due to the complexity of the biological data, they are sub-divided in four blocks. All the modelling steps on the base-level and the top-level are reported and the final QSAR model is interpreted thoroughly...
  50. ncbi Overdetermined least-squares aberration estimates using common-midpoint signals
    Mark A Haun
    Philips Research, Briarcliff Manor, NY 10510, USA
    IEEE Trans Med Imaging 23:1205-20. 2004
    ..It also appears that the signal-to-noise penalty for using complete data sets is partially compensated by the overdetermined nature of the problem...
  51. pmc Analysis of potassium spectra with low counting statistics using trapezoidal and library least-squares methods
    L M Ramirez
    Brookhaven National Laboratory, Medical Department, Upton, NY 11973, USA
    Appl Radiat Isot 61:1367-73. 2004
    ..We demonstrate, using measured and synthetic spectra, that a smaller error is obtained in the analysis of potassium when using the Library Least-Squares method...
  52. ncbi Sparse kernel density construction using orthogonal forward regression with leave-one-out test score and local regularization
    Sheng Chen
    School of Electronics and Computer Science, University of Southampton, Southampton SO17 IBJ, UK
    IEEE Trans Syst Man Cybern B Cybern 34:1708-17. 2004
    ..Our experimental results also demonstrate that the proposed algorithm compares favorably with the SVM method, in terms of both test accuracy and sparsity, for constructing kernel density estimates...
  53. ncbi Effects of nonlinearities and uncorrelated or correlated errors in realistic simulated data on the prediction abilities of augmented classical least squares and partial least squares
    David K Melgaard
    Sandia National Laboratories, Albuquerque, New Mexico 87185 0889, USA
    Appl Spectrosc 58:1065-73. 2004
  54. ncbi Classification using partial least squares with penalized logistic regression
    Gersende Fort
    CNRS LMC IMAG BP 53, 38041 Grenoble Cedex 9, France
    Bioinformatics 21:1104-11. 2005
    ..Our procedure is compared with these other classifiers. The predictive performance of the resulting classification rule is illustrated on three data sets: Leukemia, Colon and Prostate...
  55. ncbi Non-contact skin moisture measurement based on near-infrared spectroscopy
    Hidenobu Arimoto
    National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki 305 8564, Japan
    Appl Spectrosc 58:1439-46. 2004
    ..The simulation result also shows that the measurement depth of the optical method is much deeper than the depth of the capacitance method, especially in the spectral range where water absorption is relatively weak...
  56. ncbi Comparison of different fluorimetric signals for the simultaneous multivariate determination of tocopherols in vegetable oils
    T Galeano Díaz
    Department of Analytical Chemistry, University of Extremadura, Badajoz, Spain
    Appl Spectrosc 60:194-202. 2006
    ..The developed method was applied to different edible oils. The results are satisfactory for alpha-, beta-, and gamma-, but they are worse for delta-T...
  57. ncbi Simultaneous square wave voltammetric determination of 2-mercaptobenzothiazole and 2-mercaptobenzoxazole by partial least squares method in water samples
    H Parham
    Department of Chemistry, Faculty of Science, Shahid Chamran University, Ahvaz, Iran
    J Hazard Mater 151:636-41. 2008
    ..841 and 0.777 microg mL(-1) and +/-3.58 and +/-3.74% for MBT and MBO, respectively. The developed method was then applied to the analysis of these two compounds in different water samples with satisfactory results...
  58. ncbi A better lemon squeezer? Maximum-likelihood regression with beta-distributed dependent variables
    Michael Smithson
    The Australian National University, Canberra, Australian Capital Terrotory, Australia
    Psychol Methods 11:54-71. 2006
    ..The article discusses comparisons between beta regression and alternative techniques, model selection and interpretation, practical estimation, and software...
  59. ncbi Sliced inverse regression with regularizations
    Lexin Li
    Department of Statistics, North Carolina State University, Raleigh, NC 27695, USA
    Biometrics 64:124-31. 2008
    ..The L1 regularization is further introduced to achieve simultaneous reduction estimation and predictor selection. Both simulations and the analysis of a microarray expression data set demonstrate the usefulness of the proposed method...
  60. ncbi Prediction of toxicity of nitrobenzenes using ab initio and least squares support vector machines
    Ali Niazi
    Department of Chemistry, Faculty of Sciences, Azad University of Arak, Arak, Iran
    J Hazard Mater 151:603-9. 2008
    ..0049 for LS-SVM. Results have shown that the introduction of LS-SVM for quantum chemical descriptors drastically enhances the ability of prediction in QSAR studies superior to multiple linear regression and partial least squares...
  61. ncbi Multivariate calibrations in UV spectrophotometric analysis
    M Saeed Arayne
    Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 20:163-74. 2007
    ..Calibration techniques (used in the calibration step) differ in determining coefficient values for the preceding or similar equations...
  62. ncbi Quantitative analysis of paracetamol polymorphs in powder mixtures by FT-Raman spectroscopy and PLS regression
    Kyriakos Kachrimanis
    Department of Pharmaceutical Technology, School of Pharmacy, University of Thessaloniki, 54124 Thessaloniki, Greece
    J Pharm Biomed Anal 43:407-12. 2007
    ..The proposed multivariate calibration presents a significant improvement over existing methods for the quantitation of paracetamol polymorphs...
  63. ncbi Regularized estimation in the accelerated failure time model with high-dimensional covariates
    Jian Huang
    Department of Statistics and Actuarial Science, University of Iowa, Iowa City, Iowa 52242, USA
    Biometrics 62:813-20. 2006
    ..The proposed method is evaluated using simulations and demonstrated on a real data example...
  64. pmc Penalized weighted least-squares approach to sinogram noise reduction and image reconstruction for low-dose X-ray computed tomography
    Jing Wang
    Department of Radiology, State University of New York, Stony Brook, NY 11794, USA
    IEEE Trans Med Imaging 25:1272-83. 2006
    ..The KL-PWLS implementation may have the advantage in terms of computation for high-resolution dynamic low-dose CT imaging...
  65. ncbi Novel semi-automated methodology for developing highly predictive QSAR models: application for development of QSAR models for insect repellent amides
    Jayendra B Bhonsle
    Department of Medicinal Chemistry, Division of Experimental Therapeutics, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    J Mol Model 13:179-208. 2007
    ..The poses/shapes of the mined bioactive conformers provide valuable insight into the mechanism of action of the insect repellents. All of the repetitive tasks were automated using Tcl-based Cerius2 scripts...
  66. ncbi Prediction of cytotoxicity data (CC(50)) of anti-HIV 5-phenyl-1-phenylamino-1H-imidazole derivatives by artificial neural network trained with Levenberg-Marquardt algorithm
    M Arab Chamjangali
    College of Chemistry, Shahrood University of Technology, Shahrood, P O Box 36155 316, Iran
    J Mol Graph Model 26:360-7. 2007
    ..The obtained results show the validity of proposed model in the prediction of cytotoxicity data of corresponding anti-HIV drugs...
  67. ncbi Effect of the electronic and physicochemical parameters on the carcinogenesis activity of some sulfa drugs using QSAR analysis based on genetic-MLR and genetic-PLS
    Omar Deeb
    Department of Chemistry and Chemical Technology, Al Quds University, P O Box 20002, Jerusalem, Palestine
    Chemosphere 67:2122-30. 2007
    ..The results confirmed the superiority of the results obtained by GA-PLS relative to GA-MLR. The significant effect of the HOMO energy on the carcinogenic activity was explained in the context of the shape of this orbital...
  68. ncbi Multivariate curve resolution-alternating least squares and kinetic modeling applied to near-infrared data from curing reactions of epoxy resins: mechanistic approach and estimation of kinetic rate constants
    M Garrido
    Department of Analytical and Organic Chemistry, Faculty of Chemistry, Rovira i Virgili University, Tarragona, Spain
    Appl Spectrosc 60:174-81. 2006
    ..The nonlinear fitting provides the kinetic rate constants. The optimized rate constants are in agreement with values reported in the literature...
  69. ncbi New liquid chromatographic-chemometric approach for the determination of sunset yellow and tartrazine in commercial preparation
    Erdal Dinc
    Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry 06100, Tandogan, Ankara, Turkey
    J AOAC Int 88:1748-55. 2005
    ..The experimental results of the LC-chemometric approaches were compared with those obtained by a developed classical LC method using single-wavelength detection...
  70. ncbi Tandem 3D-QSARs approach as a valuable tool to predict binding affinity data: design of new Gly/NMDA receptor antagonists as a key study
    M Bacilieri
    Molecular Modeling Section, Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, I 35131 Padova, Italy
    J Chem Inf Model 47:1913-22. 2007
  71. ncbi Structural invariants for the prediction of relative toxicities of polychloro dibenzo-p-dioxins and dibenzofurans
    J M Luco
    Laboratorio de Alimentos, Facultad de Quimica, Bioquimica y Farmacia, Universidad Nacional de San Luis, Argentina
    Mol Divers 8:331-42. 2004
    ..The general trends of the group are correctly reproduced and better results are presented than have previously been published. In general, the more toxic compounds exhibit more symmetric molecular structures...
  72. ncbi Modeling calcium channel antagonistic activity of dihydropyridine derivatives using QTMS indices analyzed by GA-PLS and PC-GA-PLS
    Afshan Mohajeri
    Department of Chemistry, Shiraz University, Shiraz, Iran
    J Mol Graph Model 26:1057-65. 2008
    ..It was obtained that those belonging to the substituted 4-phenyl ring represent high influence on the biological activity which, confirms their importance in mechanism of action of DHP derivatives...
  73. pmc Prediction of valid acidity in intact apples with Fourier transform near infrared spectroscopy
    Yan de Liu
    School of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310029, China
    J Zhejiang Univ Sci B 6:158-64. 2005
    ..0677, low root mean square error of calibration (RMSEC) of 0.0562. The results indicated the feasibility of FT-NIR spectral analysis for predicting apple valid acidity in a nondestructive way...
  74. ncbi Application of Multivariate curve resolution-alternating least square methods on the resolution of overlapping CE peaks from different separation conditions
    Fang Zhang
    Institute of Analytical Science, Northwest University, Xi an, People s Republic of China
    Electrophoresis 28:3674-83. 2007
  75. ncbi Accelerated penalized weighted least-squares and maximum likelihood algorithms for reconstructing transmission images from PET transmission data
    J M M Anderson
    Department of Electrical and Computer Engineering, University of Florida, Gainesville, FL 32611, USA
    IEEE Trans Med Imaging 24:337-51. 2005
    ..In experiments using real phantom data, the PML images produced the most accurate attenuation correction factors. On the other hand, the PWLS images produced images with the highest levels of contrast for low-count data...
  76. ncbi Exploration of linear modelling techniques and their combination with multivariate adaptive regression splines to predict gastro-intestinal absorption of drugs
    E Deconinck
    Department of Analytical Chemistry and Pharmaceutical Technology, Pharmaceutical Institute, Vrije Universiteit Brussel VUB, Laarbeeklaan 103, B 1090 Brussels, Belgium
    J Pharm Biomed Anal 43:119-30. 2007
    ..This combination resulted in a model with a Pearson correlation coefficient of 0.90 and a cross-validation error, evaluated with 10-fold cross-validation of 9.9%, pointing at good descriptive and high predictive properties...
  77. ncbi Efficient least squares multimodal registration with a globally exhaustive alignment search
    Jeff Orchard
    David R Cheriton School of Computer Science, University of Waterloo, Waterloo, ON N2L 3G1, Canada
    IEEE Trans Image Process 16:2526-34. 2007
  78. ncbi Increased sensitivity in neuroimaging analyses using robust regression
    Tor D Wager
    Department of Psychology, Columbia University, New York, NY 10027, USA
    Neuroimage 26:99-113. 2005
    ..We show that IRLS can have substantial benefits in analysis of group data and in estimating hemodynamic response shapes from time series data. We provide software to implement IRLS in group neuroimaging analyses...
  79. ncbi Combining self-modeling curve resolution methods and partial least squares to develop a quantitative reaction monitoring method with minimal reference data
    Nicholas I Pedge
    Process Research and Development Department, AstraZeneca R and D Charnwood, Loughborough, Leicestershire, United Kingdom
    Appl Spectrosc 61:940-9. 2007
    ..This prompted a check of the batch temperature and it was found to be 10 degrees C lower than the required set-point. The temperature was corrected and the batch successfully reached completion in the expected time...
  80. ncbi First-order system least-squares (FOSLS) for modeling blood flow
    J J Heys
    Chemical and Materials Engineering Department, Arizona State University, Tempe, AZ 85287 6006, USA
    Med Eng Phys 28:495-503. 2006
    ..The FOSLS formulation has other benefits, including that the functional is a sharp, a posteriori error measure...
  81. pmc Regularized Least Squares Cancer classifiers from DNA microarray data
    Nicola Ancona
    Istituto di Studi sui Sistemi Intelligenti per I Automazione, CNR, Via Amendola 122 D I, 70126 Bari, Italy
    BMC Bioinformatics 6:S2. 2005
    ..The performances of both approaches have been also investigated with respect to the number of selected genes and different gene selection strategies...
  82. ncbi Fast parametric imaging algorithm for dual-input biomedical system parameter estimation
    Hon Chit Choi
    Center for Multimedia Signal Processing, Department of Electronic and Information Engineering, The Hong Kong Polytechnic University, Hong Kong
    Comput Methods Programs Biomed 81:49-55. 2006
    ..This method may be potentially applicable to other dual-input biomedical system parameter estimation as well...
  83. ncbi The fundamental constants and theory
    Peter J Mohr
    National Institute of Standards and Technology, Gaithersburg, MD 20899 8420, USA
    Philos Trans A Math Phys Eng Sci 363:2123-37. 2005
    ..An overview of the calculations that influence the recommended values of the constants will be given...
  84. pmc Length of pregnancy in African Americans: validation of a new predictive rule
    R Mittendorf
    Department of Obstetrics and Gynecology, Pritzker School of Medicine, University of Chicago, IL, USA
    J Natl Med Assoc 91:523-7. 1999
    ..When using the linear regression model rule, a more accurate EDD can be determined for African-American women. Moreover, it is possible to predict the risk of preterm delivery (those occurring > 3 weeks earlier than the EDD)...
  85. ncbi A multivariate approach applied to microarray data for identification of genes with cell cycle-coupled transcription
    Daniel Johansson
    Research Group for Chemometrics, Organic Chemistry, Department of Chemistry, Umea University, Sweden
    Bioinformatics 19:467-73. 2003
    ..5%. Among the candidates, 85% of the known periodic transcripts were included. Analysis of the three data sets separately yielded similar ranking lists, showing that the method is robust...
  86. ncbi A coded approach to system identification using a modified Golay FIR filter
    Krishna Oolun
    Department of Electrical and Electronic Engineering, Faculty of Engineering, University of Mauritius, Reduit, Mauritius
    ISA Trans 42:29-37. 2003
    ..Analysis of the results obtained from experiments, performed on a simple first-order linear time invariant (LTI) system, gave an average deviation of +/- 2.94% from the ideal response...
  87. ncbi Sensor data validation using gray models
    K M Tsang
    Department of Electrical Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong
    ISA Trans 42:9-17. 2003
    ..The quality of the measured value is determined by the prediction errors and variance of the prediction error sequence. Experimental results for detecting the quality of measurements from a thermistor are presented...
  88. pmc Implementation of a computationally efficient least-squares algorithm for highly under-determined three-dimensional diffuse optical tomography problems
    Phaneendra K Yalavarthy
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Med Phys 35:1682-97. 2008
    ..Use of these new alternative forms becomes effective when the ratio of the number of imaging property parameters exceeds the number of measurements by a factor greater than 2...
  89. ncbi Correction for ambiguous solutions in factor analysis using a penalized least squares objective
    Arkadiusz Sitek
    E O Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    IEEE Trans Med Imaging 21:216-25. 2002
    ..The results show that the technique works well in comparison to the truth in computer simulations and to region of interest (ROI) measurements in the experimental studies...
  90. ncbi Precise image-receptor calibration and monitoring of beam quality with a step wedge
    R A Couture
    Department of Radiology, Washington University, 510 South Kingshighway, St Louis, MO 63110, USA
    Dentomaxillofac Radiol 31:56-62. 2002
    ..To describe an extended bootstrap calibration procedure that uses a step-wedge absorber and minimal equipment for rapid, accurate calibration of image receptors and simultaneous monitoring of beam quality...
  91. ncbi Nondestructive near-infrared spectroscopic measurement of multiple analytes in undiluted samples of serum-based cell culture media
    Martin Rhiel
    Department of Chemical and Biochemical Engineering, University of Iowa, Iowa City, Iowa 52242, USA
    Biotechnol Bioeng 77:73-82. 2002
  92. ncbi Localization error analysis for stereo X-ray image guidance with probability method
    H Jiang
    Center for Bioengineering and School of Electrical and Computer Engineering, University of Oklahoma, Room 219, 202 West Boyd, Norman, OK 73019, USA
    Med Eng Phys 23:573-81. 2001
    ..Imaging protocols can be effectively optimized through the 3D localization error analysis using the approximate formulas proposed in this study...
  93. ncbi Evaluation of linear registration algorithms for brain SPECT and the errors due to hypoperfusion lesions
    P E Radau
    Department of Medical Biophysics, University of Western Ontario, London, Canada
    Med Phys 28:1660-8. 2001
    ..The error in quantifying the patient-template parietal ratio due to misregistration was 2.0% for large defects (70% hypoperfusion) and 0.5% for smaller defects (85% hypoperfusion)...
  94. ncbi An overview and performance evaluation of classification-based least squares trained filters
    Ling Shao
    Video Processing and Analysis Group, Philips Research Laboratories, Eindhoven, The Netherlands
    IEEE Trans Image Process 17:1772-82. 2008
    ..The results show that the performance of integrated designs is superior to that of cascaded filters when the combined applications have conflicting demands in the frequency spectrum...
  95. ncbi Artifact removal in complex frequency domain optical coherence tomography with an iterative least-squares phase-shifting algorithm
    Jung Taek Oh
    Institute for Medical Engineering, Yonsei University, Wonju, South Korea
    Appl Opt 45:4157-64. 2006
    ..A series of simulations and experiments prove that this algorithm can effectively remove strong mirror-image artifacts because it is unaffected by random phase fluctuation...
  96. ncbi A regularized kernel CCA contrast function for ICA
    Carlos Alzate
    Department of Electrical Engineering ESAT SCD SISTA, Katholieke Universiteit Leuven, B 3001 Leuven, Belgium
    Neural Netw 21:170-81. 2008
    ..Simulations with toy data, images and speech signals show improved performance on the estimation of independent components compared with existing kernel-based contrast functions...
  97. ncbi Use of the orthogonal projection approach (OPA) to monitor batch processes
    S Gourvénec
    ChemoAC, Pharmaceutical Institute, Vrije Universiteit Brussel, Laarbeeklaan 103, B 1090 Brussel, Belgium
    Appl Spectrosc 57:80-7. 2003
    ..Taking into account the variations of the process by using an augmented matrix of complete batches, the procedure explained here calculates some prediction coefficients that can afterwards be applied for a new batch...
  98. ncbi Application of two-dimensional correlation spectroscopy to chemometrics: self-modeling curve resolution analysis of spectral data sets
    Young Jung Mee
    Department of Chemistry, Pohang University of Science and Technology, San 31, Hyojadong, Pohang 790 784, Korea
    Appl Spectrosc 57:1376-80. 2003
    ..The obtained pure component spectra of MEK, d-toluene, and PS matched well with known spectra. The concentration profiles for components looked reasonable...
  99. ncbi A method based on moving least squares for XRII image distortion correction
    Shiju Yan
    Institute of Biomedical Manufacturing and Life Quality Engineering, School of Mechanical Engineering, Shanghai Jiaotong University, Shanghai, China
    Med Phys 34:4194-206. 2007
    ..2544 +/- 0.2479 pixels) is lower than that of the traditional global method (0.4223 +/- 0.3879 pixels) and local methods (0.4555 +/- 0.3518 pixels and 0.3696 +/- 0.4019 pixels, respectively)...
  100. ncbi Computationally efficient curve-fitting procedure for large two-dimensional experimental infrared spectroscopic arrays using the Pearson VII model
    Li Chen
    Department of Chemical and Environmental Engineering, 4 Engineering Drive 4, National University of Singapore, Singapore 119260
    Appl Spectrosc 57:331-7. 2003
    ..The procedure holds considerable promise for the curve fitting of massive time-series spectroscopic data, such as that arising from on-line process monitoring of expensive value-added specialty chemical and pharmaceutical syntheses...
  101. ncbi Automated method for subtraction of fluorescence from biological Raman spectra
    Chad A Lieber
    Department of Biomedical Engineering, Vanderbilt University, Station B, Box 351631, Nashville, Tennessee 37235, USA
    Appl Spectrosc 57:1363-7. 2003
    ..Results indicate that the presented automated method is proficient in fluorescence subtraction, repeatability, and in retention of Raman spectral lineshapes...

Research Grants67

  1. Effect of Chronic Proton Pump Inhibitor Therapy on Bone Mineral Density and Bone
    Yu Xiao Yang; Fiscal Year: 2013
  2. Sugar-sweetened beverage taxes, beverage purchasing patterns, and weight
    Jamie F Chriqui; Fiscal Year: 2013
  3. Understanding the malaria-poverty vicious circle
    MARCIA CALDAS DE CASTRO; Fiscal Year: 2010
    ..The research will also prepare the way to assess the economic impact of malaria control efforts in different countries, a research priority toward current malaria elimination goals. ..
  4. Engineering DNA Delivery Polymers using Combinatorial and Cheminformatics Methods
    Kaushal Rege; Fiscal Year: 2013
    ..The efficacy and biocompatibility (toxicity) of polymers and combination treatments will be evaluated in vitro and in vivo (in mice). ..
    Thomas L Vaughan; Fiscal Year: 2013
  6. Screening Lung Cancer by Ultra Low-Dose Computed Tomography
    JEROME Z LIANG; Fiscal Year: 2013
    ..PHS 398 (Rev. 04/06) Page __1___ Continuation Format Page ..
  7. Impact of Heath Information Technology on Delivery and Quality of Patient Care
    AMANDA JANE HESSELS; Fiscal Year: 2012
    ..This will impact public health by generating knowledge that may be used to direct valuable resources that will have the greatest positive effect for hospitalized patients. ..
    MICHAEL ISAAC GORAN; Fiscal Year: 2013
    ..abstract_text> ..
    Houchun H Hu; Fiscal Year: 2013
    ..This project will contribute novel and non-invasive magnetic resonance imaging techniques to accurately and reliably study fat across the entire human body. ..
  10. A Melamine Field Sensor for Surety Control of Dairy Products
    Kevin M Spencer; Fiscal Year: 2010
    ..The compact system would be fully automated and incorporate a spectral library with partial least squares analysis. Identification and quantification of melamine would be reported to the field technician...
  11. Understanding Providers Stigmatization of SMI Among Veterans
    JAN GREER SULLIVAN; Fiscal Year: 2013
    ..A series of standard ordinary least squares analysis will be used to examine the outcomes of interest.
  12. Computational tools for T- and B-cell epitope prediction
    Werner A Braun; Fiscal Year: 2010
    ..abstract_text> ..
  13. Highly multivariate quantitative trait loci mapping in systems genetics
    Ina Hoeschele; Fiscal Year: 2012
    ..Identifying key targets in regulatory networks underlying diseases is a critical step towards the development of better therapies and preventive measures for these complex diseases. ..
  14. Healthcare Associated Infections in Home Health Care
    Jingjing Shang; Fiscal Year: 2013
  15. Efficient Methods for Genotype-Specific Distributions with Unobserved Genotypes.
    Yuanjia Wang; Fiscal Year: 2013
    ..We will apply apply developed methods to analyze a kin-cohort study on Parkinson's disease, a large family study on Huntington's disease and two QTL studies. ..
  16. Computational studies of in vitro selection of RNAs
    Tamar Schlick; Fiscal Year: 2012
    ..We will interact with experimental biomedical researchers to exploit and extend our methods'capabilities for advancing the development of molecular tools for biomedical applications. ..
  17. A New Model of Peptide Fragmentation for Improved Protein Identification and Targ
    WILLIAM MARLAND OLD; Fiscal Year: 2013
    ..4) Develop an algorithm for de novo prediction of selected reaction monitoring (SRM) assays for highly multiplexed quantitative measurement of proteins in complex mixtures. ..
  18. Data-Driven Modeling of Signaling Dysregulation in Rheumatoid Arthritis
    DOUGLAS SCOTT JONES; Fiscal Year: 2013
    ..Furthermore, it will create an integrated approach that can be used to identify novel sites for therapeutic intervention in a range of other human diseases. ..
  19. Access to Care of Medicare and Medicaid Enrollees
    Marlene Niefeld; Fiscal Year: 2003
    ..If care is inappropriate or ineffective, then expanded benefits or increased payments for current services may be more important. ..
  20. Statistical Methods for Cancer Biomarkers
    JEREMY MG TAYLOR; Fiscal Year: 2013
    ..Successful completion of the aims will have an impact both in understanding and utilizing biomarkers and also in developing statistical methodology that can be more broadly applicable to other fields. ..
  21. Combinatorial analysis of migration stimuli for enhanced wound healing
    Kristyn S Masters; Fiscal Year: 2013
    ..A partial least squares regression model will be developed to analyze the data set acquired in Aims 1 and 2, enabling us to not only describe but also predict how keratinocytes integrate numerous combinations of microenvironmental cues. ..
  22. Improved DBM ROC Methods for Diagnostic Radiology
    KEVIN STALEY BERBAUM; Fiscal Year: 2010
    ..This will lead to better radiology research, which will raise the quality and lower the cost of health care. ..
  23. Refinement of Macromolecular Assembly Structure using Electron Microscopy
    Michael S Chapman; Fiscal Year: 2010
    ..A second goal is a more detailed mechanistic understanding of biomolecular complexes, going beyond domain movements to the internal conformational changes that drive them. ..
  24. The Spatiotemporal Anatomy of Seasonal Influenza in the United States, 1968
    BIANCA MALCOLM; Fiscal Year: 2011
    ..The knowledge gained as a result of this dissertation will allow public health officials to refine currnt influenza intervention strategies in order to more effectively and efficiently utilize influenza interventions. ..
  25. Feedback Control of Respiration Induced Tumor Motion with a Treatment Couch
    WARREN D D'SOUZA; Fiscal Year: 2012
    ..This will enable more widespread use of highly conformal treatments such as intensity- modulated radiation therapy (IMRT) and stereotactic body radiation therapy (SBRT) in a reliable manner. ..
  26. Systems biology approach to optimize tissue growth in vitro
    Robert T Tranquillo; Fiscal Year: 2011
    ..In this project, high- throughput cell signaling data will be obtained periodically during the incubation to adjust the incubation conditions so that tissue growth is improved. ..
  27. Untangling Racial and Gender Disparities in Health and Well-Being in the United S
    JASON LAMONT CUMMINGS; Fiscal Year: 2010
    ..abstract_text> ..
  28. Bayesian analysis of structural shape and conformation
    DOUGLAS LOWELL THEOBALD; Fiscal Year: 2013
  29. Tongue-Jaw Linkages in Feeding
    Jeffrey Palmer; Fiscal Year: 2005
    ROBIN GARDNER; Fiscal Year: 2002
    ..The development and testing of this approach is the research proposed here. ..
  31. Advancing Instrumental Variable Methods in Comparative Effectiveness Research
    Anirban Basu; Fiscal Year: 2010
    ..The goal of this application is to increase the appropriate utilization of IV methods by overcoming three important barriers to adoption of these powerful methods for CER. ..
  32. Heterogeneity and Econometric Net Cost Estimates of Schizophrenia Drug Treatments
    David Salkever; Fiscal Year: 2009
    ..Review note: This application is submitted as an R03 small grant in response to PA-06-180;the content is within the scope of "Research in Mental Health Economics" (NIMH PA-07-213). ..
    Rochelle Shain; Fiscal Year: 1991
    ..New methods for the estimation of covariance structure model with data violate the maximum-likelihood assumption will be considered...
    Patricia McGovern; Fiscal Year: 1991
  35. Improved Methods for Assessing Immune Correlates in HIV-1 Vaccine Trials
    Youyi Fong; Fiscal Year: 2013
    ..Second, three models for the shape of the concentration-response curves are compared: four-parameter logistic model, five-parameter logistic model, and a semi-parametric model. ..
  36. Models of Birthweight and Low Birthweight
    Narayan Sastry; Fiscal Year: 2004
    ..The first is the 1997 Natality Data Set (NDS), compiled from birth certificates by the National Center for Health Statistics. The second data source is the 1988 National Maternal and Infant Health Survey (NMIHS). ..
  37. Frontiers in Statistical Genetics for NIAMS Researchers
    Hemant Tiwari; Fiscal Year: 2005
    ..abstract_text> ..
    Michael Miller; Fiscal Year: 1993
    ..While we have focused on the therapy of bacterial endophthalmitis, the studies are applicable to the investigation of other classes of ocular pharmaceuticals...
  39. Parent's Schooling and Child Well-Being in Taiwan
    Michael Grossman; Fiscal Year: 2005
    ..The data collections are all birth and infant and child death certificates for 1978-2000; files with test scores; and three micro level surveys. ..
    John Moffat; Fiscal Year: 1990
    ..Calculations will be performed of the electrostatic potential and the electric field around calcium binding proteins of known structure, to investigate possible electrostatic effects in cation binding, and in intermolecular interactions...
  41. Sociodemographics and HRQL: Mapping the SF-12 and EQ-5D
    Erica Lubetkin; Fiscal Year: 2003
    ..In addition, understanding the relationship between the two measures could allow data from studies initially undertaken for one purpose (i.e. clinical trials, quality assessment) to be used for the other (i.e. CEA). ..
  42. Depression and Insulin Resistance in Type 2 Diabetes
    Patrick Lustman; Fiscal Year: 2006
    ..The findings from this study could identify a potentially modifiable factor for improving the course and outcome of those living with T2DM. [unreadable] [unreadable]..
  43. Tree Ensemble Regression and Classification Methods
    JAMES SCHIMERT; Fiscal Year: 2004
    ..This proposed software will enable medical researchers to obtain high prediction accuracy, and complement traditional tools like discriminant analysis, linear and logistic regression models, and the Cox model. ..
  44. Factors Associated with RN Decisions to Work
    Carol Brewer; Fiscal Year: 2004
    ..If successful, we will expand the tools that can be used to examine work behavior of the whole RN population, and ultimately develop relevant policy. ..
  45. Metabolomic and Isotopomer Analysis of Xenobiotic Stress
    Henri Brunengraber; Fiscal Year: 2009
    ..This will be achieved by administering low doses of 2H20 and acetaminophen, followed by measuring the 2H-labeling of urinary acetaminophen-glutathione adduct. ..
    HOWARD TUCKMAN; Fiscal Year: 1991
    ..4) A predictive model used both to classify individual hospitals and to predict how changes in policy affects profit level...
    Ke Xu; Fiscal Year: 2006
    STEWART TOLNAY; Fiscal Year: 1999
  49. Development of a Universal Calibration Method for a Noninvasive Glucometer
    ROBERT PEURA; Fiscal Year: 2009
    Patricia McGovern; Fiscal Year: 2003
    ..Knowledge of these factors will facilitate the design and testing of policy and programmatic interventions relevant to employers, policy makers and occupational health providers. ..
    Fred Bookstein; Fiscal Year: 1991
    Kimberly Rask; Fiscal Year: 1990
    ..The impact of reimbursement funds on medical care utilization and the substitution of hospital-based services for non-hospital-based services will be examined using Tobit analysis...
    David Levy; Fiscal Year: 2001
    ..abstract_text> ..
  54. Nursing Inquiry: Stress & Immune Response with Battering
    STEPHANIE WOODS; Fiscal Year: 2003
    ..abstract_text> ..
    Lee Makowski; Fiscal Year: 1992
    ..The development of this coordinated approach to the study of macromolecular assemblies holds great promise for the study of the molecular architecture of many subcellular organelles...
    David Grembowski; Fiscal Year: 1992
    ..Independent variables include patient characteristics and the characteristics of dentists providing the treatment, collected through a mail survey. Logistic, OLS and Tobit regression will be used in the data analysis...
    John Wasson; Fiscal Year: 1992
    ..The covariates (control variables) are continuity of care, patient health status and life satisfaction at entry, and patient sociodemographics (age, gender, education, income), age of physician, type of practice and urban/rural setting...
  58. Glucose Micromonitor with Radio Interface
    EDWARD WUORI; Fiscal Year: 2002
    ..The market size is measured in the billions of dollars. In addition, other emerging markets, such as the artificial pancreas, will further multiply demand for our glucose monitoring technology. ..
  59. Improving Public Health Policy for Adolescents
    JAMES ROSENQUIST; Fiscal Year: 2005
    ..Second, it pioneers in the use of genetic markers as a tool for researchers to better understand health and other economic behaviors. ..
  60. Longitudinal Analysis for Diverse Populations
    Justine Shults; Fiscal Year: 2006
    ..Further, to widely disseminate the programs, and their documentation, on a web site developed for this project. ..
    Sharon Brown; Fiscal Year: 1992
    ..A weighted least squares analysis will be performed to test the impact of weight loss strategies and subject/study variables on weight loss ..
    GRACIE BOSWELL; Fiscal Year: 2000
    ..This research will also look at how the mediators, of health-enhancing lifestyle behaviors and spiritual and religious resources, suppress the impact of this stress on the subjective outcome measures of well-being. ..
  63. Feedback Control and Inferential Modeling for Radiotherapy Treatment Couch
    WARREN D SOUZA; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
    Gerald Stubbs; Fiscal Year: 1991
    ..We plan to improve the quality of our TRV diffraction patterns, by varying the solution conditions under which specimens for X- ray diffraction experiments are made...
  65. Pregnancy Related Weight Gain: A Link to Obesity
    Anna Maria Siega Riz; Fiscal Year: 2006
    ..These data, both the quantitative and qualitative, will be used to identify modifiable behaviors for pregnant women that are associated with gaining weight above the recommended ranges and postpartum weight retention. ..
  66. Centrifrugal analysis of complex hetero-interactions
    James Cole; Fiscal Year: 2006
    ..The analysis package, along with documentation and tutorials, will be freely available over the internet. [unreadable] [unreadable]..
    Paul De Weer; Fiscal Year: 2004