Summary: The condition in which reasonable knowledge regarding risks, benefits, or the future is not available.

Top Publications

  1. ncbi Uncertainty, neuromodulation, and attention
    Angela J Yu
    Gatsby Computational Neuroscience Unit, London, United Kingdom
    Neuron 46:681-92. 2005
  2. ncbi Pvclust: an R package for assessing the uncertainty in hierarchical clustering
    Ryota Suzuki
    Department of Mathematical and Computing Sciences, Tokyo Institute of Technology 2 12 1 Ookayama, Meguro ku, Tokyo 152 8552, Japan
    Bioinformatics 22:1540-2. 2006
  3. pmc Uncertainty in heterogeneity estimates in meta-analyses
    John P A Ioannidis
    Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    BMJ 335:914-6. 2007
  4. pmc Coordinate-based activation likelihood estimation meta-analysis of neuroimaging data: a random-effects approach based on empirical estimates of spatial uncertainty
    Simon B Eickhoff
    Institut for Neuroscience and Biophysics Medicine INB 3, Research Center Julich, Julich, Germany
    Hum Brain Mapp 30:2907-26. 2009
  5. pmc A methodology for performing global uncertainty and sensitivity analysis in systems biology
    Simeone Marino
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109 0620, USA
    J Theor Biol 254:178-96. 2008
  6. ncbi Choice, uncertainty and value in prefrontal and cingulate cortex
    Matthew F S Rushworth
    Department of Experimental Psychology and Centre for Functional MRI of the Brain, John Radcliffe Hospital, University of Oxford, South Parks Road, Oxford OX1 3UD, UK
    Nat Neurosci 11:389-97. 2008
  7. pmc Accounting for alignment uncertainty in phylogenomics
    Martin Wu
    Department of Biology, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS ONE 7:e30288. 2012
  8. ncbi Neural systems responding to degrees of uncertainty in human decision-making
    Ming Hsu
    Division of Humanities and Social Sciences, 228 77, California Institute of Technology, Pasadena, CA 91125, USA
    Science 310:1680-3. 2005
  9. ncbi A common role of insula in feelings, empathy and uncertainty
    Tania Singer
    Laboratory for Social and Neural Systems Research, University of Zurich, Switzerland
    Trends Cogn Sci 13:334-40. 2009
  10. ncbi Knowing how much you don't know: a neural organization of uncertainty estimates
    Dominik R Bach
    Wellcome Trust Centre for Neuroimaging, University College London, UK
    Nat Rev Neurosci 13:572-86. 2012

Detail Information

Publications354 found, 100 shown here

  1. ncbi Uncertainty, neuromodulation, and attention
    Angela J Yu
    Gatsby Computational Neuroscience Unit, London, United Kingdom
    Neuron 46:681-92. 2005
    b>Uncertainty in various forms plagues our interactions with the environment...
  2. ncbi Pvclust: an R package for assessing the uncertainty in hierarchical clustering
    Ryota Suzuki
    Department of Mathematical and Computing Sciences, Tokyo Institute of Technology 2 12 1 Ookayama, Meguro ku, Tokyo 152 8552, Japan
    Bioinformatics 22:1540-2. 2006
    Pvclust is an add-on package for a statistical software R to assess the uncertainty in hierarchical cluster analysis...
  3. pmc Uncertainty in heterogeneity estimates in meta-analyses
    John P A Ioannidis
    Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    BMJ 335:914-6. 2007
  4. pmc Coordinate-based activation likelihood estimation meta-analysis of neuroimaging data: a random-effects approach based on empirical estimates of spatial uncertainty
    Simon B Eickhoff
    Institut for Neuroscience and Biophysics Medicine INB 3, Research Center Julich, Julich, Germany
    Hum Brain Mapp 30:2907-26. 2009
    ..variability for 16 functionally defined regions, which were then used to explicitly model the spatial uncertainty associated with each reported coordinate...
  5. pmc A methodology for performing global uncertainty and sensitivity analysis in systems biology
    Simeone Marino
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109 0620, USA
    J Theor Biol 254:178-96. 2008
    ..However, these methods do not accurately assess uncertainty and sensitivity in the system as, by default, they hold all other parameters fixed at baseline values...
  6. ncbi Choice, uncertainty and value in prefrontal and cingulate cortex
    Matthew F S Rushworth
    Department of Experimental Psychology and Centre for Functional MRI of the Brain, John Radcliffe Hospital, University of Oxford, South Parks Road, Oxford OX1 3UD, UK
    Nat Neurosci 11:389-97. 2008
    ..Moreover, decisions are not guided solely by the magnitude of the reward that is expected. Uncertainty in the estimate of the reward expectation, the value of information that might be gained by taking a course of ..
  7. pmc Accounting for alignment uncertainty in phylogenomics
    Martin Wu
    Department of Biology, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS ONE 7:e30288. 2012
    b>Uncertainty in multiple sequence alignments has a large impact on phylogenetic analyses...
  8. ncbi Neural systems responding to degrees of uncertainty in human decision-making
    Ming Hsu
    Division of Humanities and Social Sciences, 228 77, California Institute of Technology, Pasadena, CA 91125, USA
    Science 310:1680-3. 2005
    ..Neurological subjects with orbitofrontal lesions were insensitive to the level of ambiguity and risk in behavioral choices. These data suggest a general neural circuit responding to degrees of uncertainty, contrary to decision theory.
  9. ncbi A common role of insula in feelings, empathy and uncertainty
    Tania Singer
    Laboratory for Social and Neural Systems Research, University of Zurich, Switzerland
    Trends Cogn Sci 13:334-40. 2009
    ..accumulating evidence highlights a crucial role of the insular cortex in feelings, empathy and processing uncertainty in the context of decision making, neuroscientific models of affective learning and decision making have mostly ..
  10. ncbi Knowing how much you don't know: a neural organization of uncertainty estimates
    Dominik R Bach
    Wellcome Trust Centre for Neuroimaging, University College London, UK
    Nat Rev Neurosci 13:572-86. 2012
    How we estimate uncertainty is important in decision neuroscience and has wide-ranging implications in basic and clinical neuroscience, from computational models of optimality to ideas on psychopathological disorders including anxiety, ..
  11. pmc Cortical substrates for exploratory decisions in humans
    Nathaniel D Daw
    Gatsby Computational Neuroscience Unit, University College London UCL, Alexandra House, 17 Queen Square, London WC1N 3AR, UK
    Nature 441:876-9. 2006
    ..The results suggest a model of action selection under uncertainty that involves switching between exploratory and exploitative behavioural modes, and provide a computationally ..
  12. ncbi Correlating viral phenotypes with phylogeny: accounting for phylogenetic uncertainty
    Joe Parker
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, United Kingdom
    Infect Genet Evol 8:239-46. 2008
    ..This method accounts for uncertainty arising from phylogenetic error and provides a statistical significance test of the null hypothesis that traits ..
  13. ncbi Neural correlates, computation and behavioural impact of decision confidence
    Adam Kepecs
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nature 455:227-31. 2008
    ..We suggest that confidence estimation may be a fundamental and ubiquitous component of decision-making...
  14. ncbi Improving GO semantic similarity measures by exploring the ontology beneath the terms and modelling uncertainty
    Haixuan Yang
    Department of Computer Science and Centre for Systems and Synthetic Biology, Royal Holloway, University of London, Egham, TW20 0EX, UK
    Bioinformatics 28:1383-9. 2012
    ..Second, existing similarity measures do not model the inherent uncertainty which comes from the fact that our current knowledge of the gene annotation and of the ontology structure is ..
  15. ncbi The comparative psychology of uncertainty monitoring and metacognition
    J David Smith
    Department of Psychology and Center for Cognitive Science, State University of New York at Buffalo, Buffalo, NY 14260, USA
    Behav Brain Sci 26:317-39; discussion 340-73. 2003
    Researchers have begun to explore animals' capacities for uncertainty monitoring and metacognition. This exploration could extend the study of animal self-awareness and establish the relationship of self-awareness to other-awareness...
  16. ncbi Climate change impacts on tree ranges: model intercomparison facilitates understanding and quantification of uncertainty
    Alissar Cheaib
    Laboratoire d Ecologie, Systématique et Evolution ESE, Univ Paris Sud, UMR 8079 CNRS Univ Paris Sud AgroParisTech, Orsay Cedex, France
    Ecol Lett 15:533-44. 2012
    ..However, poorly evaluated sources of uncertainty require more scrutiny before relying heavily on models for decision-making...
  17. ncbi Oxytocin and cooperation under conditions of uncertainty: the modulating role of incentives and social information
    Carolyn H Declerck
    University of Antwerp, Faculty of Applied Economics, Antwerpen, Belgium
    Horm Behav 57:368-74. 2010
    ..When these cues are absent, OT appears to instead elicit a risk-averse strategy...
  18. pmc Fast, single-molecule localization that achieves theoretically minimum uncertainty
    Carlas S Smith
    Department of Imaging Science and Technology, Delft University of Technology, The Netherlands
    Nat Methods 7:373-5. 2010
  19. ncbi Comparing niche- and process-based models to reduce prediction uncertainty in species range shifts under climate change
    Xavier Morin
    Centre d Ecologie Fonctionnelle et Evolutive, Unite Mixte de Recherche, Centre National de la Recherche Scientifique 5175, Equipe BIOFLUX, CNRS, 1919, route de Mende, 34293 Montpellier Cedex 5, France
    Ecology 90:1301-13. 2009
  20. ncbi Climate change and forests of the future: managing in the face of uncertainty
    Constance I Millar
    USDA Forest Service, Sierra Nevada Research Center, Pacific Southwest Research Station, 800 Buchanan Street, Albany, California 94710, USA
    Ecol Appl 17:2145-51. 2007
    ..Priority-setting approaches (e.g., triage), appropriate for rapidly changing conditions and for situations where needs are greater than available capacity to respond, will become increasingly important in the future...
  21. pmc A general Bayesian treatment for MEG source reconstruction incorporating lead field uncertainty
    J D Lopez
    Mechatronics School, Bl M8 108 Facultad de Minas, Universidad Nacional de Colombia, Medellin, Colombia
    Neuroimage 60:1194-204. 2012
    There is uncertainty introduced when a cortical surface based model derived from an anatomical MRI is used to reconstruct neural activity with MEG data...
  22. ncbi Bayesian theories of conditioning in a changing world
    Aaron C Courville
    Département d informatique et de recherche opérationnelle, Universite de Montreal, Montreal, QC H3C 3J7, Canada
    Trends Cogn Sci 10:294-300. 2006
    ..We suggest that, in a statistical account of conditioning, surprise signals change and therefore uncertainty and the need for new learning...
  23. pmc Prospective strategies to delay the evolution of anti-malarial drug resistance: weighing the uncertainty
    David L Smith
    Emerging Pathogens Institute and Department of Biology, University of Florida, Gainesville, 32611, USA
    Malar J 9:217. 2010
    ..Such strategies are deployed to best effect before resistance has emerged, under conditions of great uncertainty.
  24. pmc A Bayesian approach to targeted experiment design
    J Vanlier
    Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    Bioinformatics 28:1136-42. 2012
    ..amount of experimental data on which the models are parameterized is often limited, these models exhibit large uncertainty in both parameters and predictions...
  25. pmc Exploring uncertainty in the calibration of the molecular clock
    Rachel C M Warnock
    School of Earth Sciences, University of Bristol, Bristol, UK
    Biol Lett 8:156-9. 2012
    ..Bayesian approaches to divergence time estimation make it possible to incorporate the uncertainty in the degree to which fossil evidence approximates the true time of divergence...
  26. pmc Near optimal combination of sensory and motor uncertainty in time during a naturalistic perception-action task
    A Aldo Faisal
    Dept of Engineering, Univ of Cambridge, Trumpington St, CB2 1PZ Cambridge, UK
    J Neurophysiol 101:1901-12. 2009
    ..In general, the longer we perceive, the smaller the uncertainty in perceptual estimates...
  27. pmc Evolution of direct reciprocity under uncertainty can explain human generosity in one-shot encounters
    Andrew W Delton
    Center for Evolutionary Psychology, Department of Psychology and Anthropology, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 108:13335-40. 2011
    ..the necessary byproduct of selection on decision systems for regulating dyadic reciprocity under conditions of uncertainty. In deciding whether to engage in dyadic reciprocity, these systems must balance (i) the costs of mistaking a ..
  28. pmc "Could this be something serious?" Reassurance, uncertainty, and empathy in response to patients' expressions of worry
    Ronald M Epstein
    Department of Family Medicine, Rochester, NY, USA
    J Gen Intern Med 22:1731-9. 2007
    ..Previous work suggests that exploration and validation of patients' concerns is associated with greater patient trust, lower health care costs, improved counseling, and more guideline-concordant care...
  29. ncbi Uncertainty in assessing the impacts of global change with coupled dynamic species distribution and population models
    Erin Conlisk
    Department of Biology, Center for Conservation Biology, University of California, 900 University Ave, Riverside, CA 92521, USA
    Glob Chang Biol 19:858-69. 2013
    ..Each modelling component introduces its own source of uncertainty through different parameters and assumptions, which, when combined, can result in compounded uncertainty that ..
  30. ncbi Network resets in medial prefrontal cortex mark the onset of behavioral uncertainty
    Mattias P Karlsson
    Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA
    Science 338:135-9. 2012
    ..These dynamics reflect network switches to a state of instability, which diminishes over the period of exploration as new stable representations are formed...
  31. ncbi Model parameter estimation and uncertainty: a report of the ISPOR-SMDM Modeling Good Research Practices Task Force--6
    Andrew H Briggs
    Health Economics and Health Technology Assessment, Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK
    Value Health 15:835-42. 2012
    ..point estimate for a specific outcome but also in the systematic examination and responsible reporting of uncertainty surrounding this outcome and the ultimate decision being addressed...
  32. ncbi Parameter uncertainty analysis of non-point source pollution from different land use types
    Zhen yao Shen
    State Key Laboratory of Water Environment Simulation, School of Environment, Beijing Normal University, Beijing, P R China
    Sci Total Environ 408:1971-8. 2010
    Land use type is one of the most important factors that affect the uncertainty in non-point source (NPS) pollution simulation...
  33. ncbi Model parameter estimation and uncertainty analysis: a report of the ISPOR-SMDM Modeling Good Research Practices Task Force Working Group-6
    Andrew H Briggs
    Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK
    Med Decis Making 32:722-32. 2012
    ..point estimate for a specific outcome but also in the systematic examination and responsible reporting of uncertainty surrounding this outcome and the ultimate decision being addressed...
  34. ncbi Characterizing structural uncertainty in decision analytic models: a review and application of methods
    Laura Bojke
    Centre for Health Economics, University of York, York, UK
    Value Health 12:739-49. 2009
    The characterization of uncertainty is critical in cost-effectiveness analysis, particularly when considering whether additional evidence is needed...
  35. pmc Risk, unexpected uncertainty, and estimation uncertainty: Bayesian learning in unstable settings
    Elise Payzan-LeNestour
    University of New South Wales, Sydney, Australia
    PLoS Comput Biol 7:e1001048. 2011
    ..Here, we investigate what this implies for human appreciation of uncertainty. In our task, a Bayesian learner distinguishes three equally salient levels of uncertainty...
  36. ncbi Decision-making under great uncertainty: environmental management in an era of global change
    Stephen Polasky
    Department of Applied Economics, University of Minnesota, St Paul, MN 55108, USA
    Trends Ecol Evol 26:398-404. 2011
    ..Standard approaches to decision-making under uncertainty require information about the likelihood of alternative states, how states and actions combine to form outcomes ..
  37. ncbi The experimental uncertainty of heterogeneous public K(i) data
    Christian Kramer
    Novartis Institutes for BioMedical Research, Novartis Pharma AG, Forum 1, Novartis Campus, CH 4056 Basel, Switzerland
    J Med Chem 55:5165-73. 2012
    ..Consequently, experimental uncertainty defines a natural upper limit to the predictive performance possible...
  38. ncbi Visualizing uncertainty about the future
    David Spiegelhalter
    Centre for Mathematical Sciences, University of Cambridge, Cambridge CB3 0WB, UK
    Science 333:1393-400. 2011
    We are all faced with uncertainty about the future, but we can get the measure of some uncertainties in terms of probabilities...
  39. ncbi Decision-making under uncertainty: biases and Bayesians
    Pete C Trimmer
    Department of Computer Science, University of Bristol, UK
    Anim Cogn 14:465-76. 2011
    ..This paper reviews the theoretical side of decision-making under uncertainty, particularly with regard to unknown risk (ambiguity)...
  40. pmc Bayesian models: the structure of the world, uncertainty, behavior, and the brain
    Iris Vilares
    Departments of Physical Medicine and Rehabilitation, Physiology, and Applied Mathematics, Northwestern University, 345E Superior St Onterie, Chicago, IL 60611, USA
    Ann N Y Acad Sci 1224:22-39. 2011
    Experiments on humans and other animals have shown that uncertainty due to unreliable or incomplete information affects behavior. Recent studies have formalized uncertainty and asked which behaviors would minimize its effect...
  41. ncbi Future uncertainty and socioeconomic inequalities in health: the Whitehall II study
    Jane E Ferrie
    Department of Epidemiology and Public Health, University College London Medical School, London, UK
    Soc Sci Med 57:637-46. 2003
    ..These findings imply that the specific effects of job insecurity in this cohort may be less important than the more general effects of financial insecurity in determining inequalities in health...
  42. ncbi Rapid word learning under uncertainty via cross-situational statistics
    Chen Yu
    Department of Psychological and Brain Sciences and Program in Cognitive Science, Indiana University, IN 47405, USA
    Psychol Sci 18:414-20. 2007
    ..Different learning conditions varied the degree of within-trial reference uncertainty, the number of trials, and the length of trials...
  43. pmc A comparison of approaches to account for uncertainty in analysis of imputed genotypes
    Jin Zheng
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA
    Genet Epidemiol 35:102-10. 2011
    ..A natural question when implementing these procedures concerns how best to take into account uncertainty in imputed genotypes...
  44. ncbi Thinking outside the box: recent advances in the analysis and presentation of uncertainty in cost-effectiveness studies
    Andrew H Briggs
    Health Economics Research Centre, Department of Public Health, University of Oxford, Oxford OX3 7LF, United Kingdom
    Annu Rev Public Health 23:377-401. 2002
    ..In particular, we focus on the handling and presentation of uncertainty, including the importance of estimation rather than hypothesis testing, the use of the net-benefit statistic, ..
  45. ncbi Beta-band activity during motor planning reflects response uncertainty
    Charidimos Tzagarakis
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, United Kingdom
    J Neurosci 30:11270-7. 2010
    ..Here, we examined whether the degree of uncertainty about the upcoming movement direction modulated beta-band desynchronization during motor preparation...
  46. ncbi Accounting for phylogenetic uncertainty in biogeography: a Bayesian approach to dispersal-vicariance analysis of the thrushes (Aves: Turdus)
    Johan A A Nylander
    School of Computational Science, Florida State University, Tallahassee, Florida 32306, USA
    Syst Biol 57:257-68. 2008
    ..Here, we apply a Bayesian approach to dispersal-vicariance analysis that accounts for phylogenetic uncertainty and allows a more accurate analysis of the biogeographic history of lineages...
  47. pmc Rostrolateral prefrontal cortex and individual differences in uncertainty-driven exploration
    David Badre
    Department of Cognitive, Linguistic, and Psychological Sciences, Brown Institute for Brain Sciences, Brown University, Providence, RI 02912 1978, USA
    Neuron 73:595-607. 2012
    ..outcome? Recent evidence suggests that individuals may strategically explore as a function of the relative uncertainty about the expected value of options...
  48. pmc Sloppy models, parameter uncertainty, and the role of experimental design
    Joshua F Apgar
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Mol Biosyst 6:1890-900. 2010
  49. pmc An integrated strategy for prediction uncertainty analysis
    J Vanlier
    Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    Bioinformatics 28:1130-5. 2012
    ..biological pathways in combination with the limited amount of quantitative data results in large parameter uncertainty which propagates into model predictions...
  50. pmc Influence of uncertainty and surprise on human corticospinal excitability during preparation for action
    Sven Bestmann
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, UK
    Curr Biol 18:775-80. 2008
    ..We systematically varied the uncertainty about an impending action by changing the validity of the instructive visual cue...
  51. ncbi A neural representation of categorization uncertainty in the human brain
    Jack Grinband
    Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    Neuron 49:757-63. 2006
    ..Psychophysical functions were used to define a decision variable, categorization uncertainty, which was systematically manipulated...
  52. pmc Implicit knowledge of visual uncertainty guides decisions with asymmetric outcomes
    Louise Whiteley
    Gatsby Computational Neuroscience Unit, University College London, London, UK
    J Vis 8:2.1-15. 2008
    ..by noise (Green & Swets, 1989), requiring the brain to compute perceptual beliefs under conditions of uncertainty. Here we show that human observers performing a simple visual choice task under an externally imposed loss ..
  53. ncbi Accounting for methodological, structural, and parameter uncertainty in decision-analytic models: a practical guide
    Joke Bilcke
    Center for Health Economic Research and Modeling for Infectious Diseases CHERMID, Vaccine and Infectious Disease Institute VAXINFECTIO, Antwerp University, Antwerp, Belgium
    Med Decis Making 31:675-92. 2011
    Accounting for uncertainty is now a standard part of decision-analytic modeling and is recommended by many health technology agencies and published guidelines...
  54. ncbi Uncertainty analysis for 3D image-based cervix cancer brachytherapy by repetitive MR imaging: assessment of DVH-variations between two HDR fractions within one applicator insertion and their clinical relevance
    Stefan Lang
    Department of Radiotherapy, Comprehensive Cancer Center, Medical University of Vienna, Austria
    Radiother Oncol 107:26-31. 2013
    ..To investigate dosimetric uncertainties of MRI-based cervix cancer brachytherapy, when applying two HDR fractions for each applicator insertion and their clinical relevance...
  55. ncbi Accounting for uncertainty in marine reserve design
    Benjamin S Halpern
    National Center for Ecological Analysis and Synthesis, 735 State St, Santa Barbara, CA 93101, USA
    Ecol Lett 9:2-11; discussion 11-4. 2006
    ..Managing and conserving these systems in the face of uncertainty remains a daunting challenge, particularly with respect to developing networks of marine reserves...
  56. ncbi Empirical uncertainty and moral contest: a qualitative analysis of the relationship between medical specialists and the pharmaceutical industry in Australia
    E Doran
    Discipline of Clinical Pharmacology, School of Medical Practice and Population Health, University of Newcastle, New South Wales, Australia
    Soc Sci Med 62:1510-9. 2006
  57. pmc PPAR-γ as a therapeutic target in cardiovascular disease: evidence and uncertainty
    Janice V Huang
    Cardiology Section, Denver VA Medical Center, US Department of Veterans Affairs, Denver, CO, USA
    J Lipid Res 53:1738-54. 2012
    ..This review addresses these issues from a clinician's perspective and highlights several ongoing clinical trials that may help to clarify the therapeutic role of PPAR-γ activators in cardiovascular disease...
  58. ncbi Range uncertainty in proton therapy due to variable biological effectiveness
    Alejandro Carabe
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Phys Med Biol 57:1159-72. 2012
    ..The results of our study allow a quantitative consideration of RBE-caused range uncertainties as a function of treatment site and dose in treatment planning...
  59. pmc Gaussian process regression bootstrapping: exploring the effects of uncertainty in time course data
    Paul D W Kirk
    Centre for Bioinformatics, Division of Molecular Biosciences, Imperial College London, London SW7 2AZ, UK
    Bioinformatics 25:1300-6. 2009
    Although widely accepted that high-throughput biological data are typically highly noisy, the effects that this uncertainty has upon the conclusions we draw from these data are often overlooked...
  60. pmc Communicating uncertainty can lead to less decision satisfaction: a necessary cost of involving patients in shared decision making?
    Mary C Politi
    Department of Surgery, Washington University School of Medicine, Wales, UK
    Health Expect 14:84-91. 2011
    Given the large number of interventions of uncertain effectiveness, research on communicating uncertainty is needed to examine its impact on patients' health decisions.
  61. ncbi Dealing with uncertainty in general practice: an essential skill for the general practitioner
    Margaret O'Riordan
    Centre for Health Sciences Research, Cardiff University, Neuadd Meirionnydd, Wales, UK
    Qual Prim Care 19:175-81. 2011
    Many patients attending general practice do not have an obvious diagnosis at presentation. Skills to deal with uncertainty are particularly important in general practice as undifferentiated and unorganised problems are a common challenge ..
  62. ncbi Impact and uncertainty of a traffic management intervention: population exposure to polycyclic aromatic hydrocarbons
    Sotiris Vardoulakis
    Public and Environmental Health Research Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Sci Total Environ 394:244-51. 2008
    ..air pollutants has often been quantified in a deterministic manner that disregards the various sources of uncertainty in the modelling systems used...
  63. pmc Practical issues in handling data input and uncertainty in a budget impact analysis
    M J C Nuijten
    Institute for Medical Technology Assessment iMTA, Erasmus University Rotterdam, PO Box 1738, Rotterdam, 3000 DR, Rotterdam, The Netherlands
    Eur J Health Econ 12:231-41. 2011
    The objective of this paper was to address the importance of dealing systematically and comprehensively with uncertainty in a budget impact analysis (BIA) in more detail...
  64. ncbi Reducing the uncertainty in measurement and understanding of mercury in the atmosphere
    Mae Gustin
    Department of Natural Resources and Environmental Science, University of Nevada Reno, USA
    Environ Sci Technol 44:2222-7. 2010
    ..Elucidating the extent of mercury in the atmosphere requires deployment of robust and sensitive instruments...
  65. ncbi Social context, the struggle with uncertainty, and subjective risk as meaning-rich constructs for explaining HBP noncompliance
    Michelle Proulx
    Equipe sur le Médicament Comme Objet Social et Culturel MEOS, Faculte de Pharmacie, Universite de Montreal, Canada
    Patient Educ Couns 68:98-106. 2007
    ..To identify the reasons for which people fail to take blood-pressure-lowering medication regularly, a qualitative study was conducted...
  66. ncbi Coping with uncertainty: T1a,bN0M0 HER2-positive breast cancer, do we have a treatment threshold?
    C M Kelly
    Department of Medical Oncology, Waterford Regional Hospital, Dunmore Road, Waterford, Ireland
    Ann Oncol 22:2387-93. 2011
    ..The absolute benefits associated with treating this subgroup are uncertain...
  67. ncbi Estimating toxicity-related biological pathway altering doses for high-throughput chemical risk assessment
    Richard S Judson
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, United States
    Chem Res Toxicol 24:451-62. 2011
    ..assay data and an in vitro-derived pharmacokinetic model, coupled with estimates of population variability and uncertainty. The quantity we calculate, the biological pathway altering dose (BPAD), is analogous to current risk ..
  68. pmc Probabilistic models in human sensorimotor control
    Daniel M Wolpert
    Computational and Biological Learning Group, Department of Engineering, University of Cambridge, Trumpington Street, Cambridge CB2 1PZ, Cambridge, UK
    Hum Mov Sci 26:511-24. 2007
    Sensory and motor uncertainty form a fundamental constraint on human sensorimotor control...
  69. pmc Coping with environmental uncertainty: dynamic bet hedging as a maternal effect
    Angela J Crean
    School of Integrative Biology, University of Queensland, 4072 Brisbane, Queensland, Australia
    Philos Trans R Soc Lond B Biol Sci 364:1087-96. 2009
    ..but what happens when the offspring's environment is unpredictable? Theory suggests that when mothers face uncertainty regarding their offspring's environment, they should increase within-clutch variation in the offspring ..
  70. pmc Assessing the risk of bluetongue to UK livestock: uncertainty and sensitivity analyses of a temperature-dependent model for the basic reproduction number
    Simon Gubbins
    Institute for Animal Health, Pirbright Laboratory, Ash Road, Pirbright, Surrey GU24 0NF, UK
    J R Soc Interface 5:363-71. 2008
    ..Moreover, explicit temperature dependence was included for those parameters for which it had been quantified. Uncertainty and sensitivity analyses based on Latin hypercube sampling and partial rank correlation coefficients identified ..
  71. pmc A dosimetric uncertainty analysis for photon-emitting brachytherapy sources: report of AAPM Task Group No. 138 and GEC-ESTRO
    Larry A DeWerd
    Department of Medical Physics and Accredited Dosimetry Calibration Laboratory, University of Wisconsin, Madison, Wisconsin 53706, USA
    Med Phys 38:782-801. 2011
    ..The International Organization for Standardization (ISO) Guide to the Expression of Uncertainty in Measurement (GUM) and the National Institute of Standards and Technology (NIST) Technical Note 1297 are ..
  72. pmc From uncertainty to reward: BOLD characteristics differentiate signaling pathways
    Birgit Abler
    Department of Psychiatry, University of Ulm, Leimgrubenweg 12 14, 89075 Ulm, Germany
    BMC Neurosci 10:154. 2009
    Reward value and uncertainty are represented by dopamine neurons in monkeys by distinct phasic and tonic firing rates...
  73. ncbi Uncertainty analysis of least-cost modeling for designing wildlife linkages
    Paul Beier
    School of Forestry and Merriam Powell Center for Environmental Research, Northern Arizona University, Flagstaff, Arizona 86011 5018, USA
    Ecol Appl 19:2067-77. 2009
    ..Each model produced a proposed corridor for that species. We examined the extent to which uncertainty in factor weights and class resistance values affected two key conservation-relevant outputs, namely, the ..
  74. ncbi Physicians' reactions to uncertainty in the context of shared decision making
    Mary C Politi
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63112 1408, USA
    Patient Educ Couns 80:155-7. 2010
    Physicians' reactions towards uncertainty may influence their willingness to engage in shared decision making (SDM)...
  75. ncbi Risk of tumorigenesis in first-in-human trials of embryonic stem cell neural derivatives: Ethics in the face of long-term uncertainty
    Pascale G Hess
    Dalhousie University, Halifax, Canada
    Account Res 16:175-98. 2009
    ..These challenges are examined within the context of foreseen trials for disorders of the central nervous system...
  76. pmc Communicating uncertainty--how Australian television reported H1N1 risk in 2009: a content analysis
    Andrea S Fogarty
    School of Public Health, University of Sydney, Sydney, Australia
    BMC Public Health 11:181. 2011
    ..This paper presents a case-study of news communication regarding the emergence of pH1N1...
  77. pmc A computational model of limb impedance control based on principles of internal model uncertainty
    Djordje Mitrovic
    IPAB, School of Informatics, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 5:e13601. 2010
    ..this computational model could be used to interpret existing experimental impedance control data from the viewpoint of optimality or could even govern the design of future experiments based on principles of internal model uncertainty.
  78. ncbi The hippocampus codes the uncertainty of cue-outcome associations: an intracranial electrophysiological study in humans
    Giovanna Vanni-Mercier
    Center for Cognitive Neuroscience, Reward and Decision Making Group, CNRS, UMR 5229, Universite Lyon 1, 69675 Bron Cedex, France
    J Neurosci 29:5287-94. 2009
    ..midbrain dopaminergic neurons code two statistical properties of reward: a prediction error at the outcome and uncertainty during the delay period between cues and outcomes...
  79. pmc Risk-sensitive optimal feedback control accounts for sensorimotor behavior under uncertainty
    Arne J Nagengast
    Computational and Biological Learning Lab, Department of Engineering, University of Cambridge, Cambridge, United Kingdom
    PLoS Comput Biol 6:e1000857. 2010
    ..controller) or as an added value (risk-seeking controller) to model human motor behavior in the face of uncertainty. We use a sensorimotor task to test the hypothesis that subjects are risk-sensitive...
  80. ncbi Modulation of pain ratings by expectation and uncertainty: Behavioral characteristics and anticipatory neural correlates
    Christopher A Brown
    Human Pain Research Group, Clinical Sciences Building, Hope Hospital, Salford M6 8HD, United Kingdom
    Pain 135:240-50. 2008
    ..Source analysis (LORETA) revealed that uncertainty about expected heat intensity involves an anticipatory cortical network commonly associated with attention (..
  81. ncbi Coverage with evidence development: an examination of conceptual and policy issues
    John Hutton
    University of York, York Y010 5DD, UK
    Int J Technol Assess Health Care 23:425-32. 2007
    ..CED demands that additional evidence is generated to address the sources of uncertainty and secure ongoing coverage...
  82. ncbi Accounting for uncertainty in ecological analysis: the strengths and limitations of hierarchical statistical modeling
    Noel Cressie
    Program in Spatial Statistics and Environmental Statistics, Department of Statistics, Ohio State University, Columbus, Ohio 43210, USA
    Ecol Appl 19:553-70. 2009
    Analyses of ecological data should account for the uncertainty in the process(es) that generated the data. However, accounting for these uncertainties is a difficult task, since ecology is known for its complexity...
  83. ncbi Discrete coding of reward probability and uncertainty by dopamine neurons
    Christopher D Fiorillo
    Institute of Physiology, University of Fribourg, CH 1700 Fribourg, Switzerland
    Science 299:1898-902. 2003
    b>Uncertainty is critical in the measure of information and in assessing the accuracy of predictions. It is determined by probability P, being maximal at P = 0.5 and decreasing at higher and lower probabilities...
  84. ncbi Uncertainty assessment of input parameters for economic evaluation: Gauss's error propagation, an alternative to established methods
    Björn Stollenwerk
    Institute of Health Economics and Clinical Epidemiology of the University of Cologne, Gleueler Strasse Cologne, Germany
    Med Decis Making 30:304-13. 2010
    ..evaluation, bootstrapping and the Cholesky decomposition method are frequently used to assess parameter uncertainty and to support probabilistic sensitivity analysis...
  85. ncbi The effects of uncertainty in error monitoring on associated ERPs
    Patricia E Pailing
    Department of Psychology, University of Waterloo, Ont, Canada
    Brain Cogn 56:215-33. 2004
    A series of experiments were conducted to address the effect of uncertainty regarding performance for predicting the likelihood of a correct-response negativity (CRN) in addition to error-related negativity (ERN)...
  86. pmc Uncertainties associated with quantifying climate change impacts on human health: a case study for diarrhea
    Erik W Kolstad
    Uni Bjerknes Centre, Bergen, Norway
    Environ Health Perspect 119:299-305. 2011
    ..Climate change is expected to have large impacts on health at low latitudes where droughts and malnutrition, diarrhea, and malaria are projected to increase...
  87. ncbi Cancer in the mass print media: fear, uncertainty and the medical model
    Juanne N Clarke
    Wilfrid Laurier University Waterloo, Ont, Canada
    Soc Sci Med 62:2591-600. 2006
    ..The paper concludes with a discussion of the implications of the linking of fear with cancer in the context of medicine as the solution...
  88. pmc Equipoise, design bias, and randomized controlled trials: the elusive ethics of new drug development
    James F Fries
    Stanford University School of Medicine, Palo Alto, California, USA
    Arthritis Res Ther 6:R250-5. 2004
    The concept of 'equipoise', or the 'uncertainty principle', has been represented as a central ethical principle, and holds that a subject may be enrolled in a randomized controlled trial (RCT) only if there is true uncertainty about ..
  89. ncbi Variants of uncertainty in decision-making and their neural correlates
    Kirsten G Volz
    Max Planck Institute for Human Cognitive and Brain Sciences, PO Box 500 355, D 04303 Leipzig, Germany
    Brain Res Bull 67:403-12. 2005
    ..refer to them as a family of subjective probability concepts or following Kahneman and Tversky, as variants of uncertainty. The authors distinguished between external and internal attributions of uncertainty and could show that the ..
  90. ncbi Human midbrain sensitivity to cognitive feedback and uncertainty during classification learning
    A R Aron
    Dept of Psychology and Brain Research Institute, University of California Los Angeles, CA 90065, USA
    J Neurophysiol 92:1144-52. 2004
    ..ventral striatal, orbital, and medial frontal regions, as well as by showing sensitivity to the degree of uncertainty associated with individual stimuli...
  91. ncbi Outcomes of an intervention to reduce uncertainty among African American women with diabetes
    Emelia Amoako
    School of Nursing, The University of North Carolina at Greensboro, Greensboro, NC 27402 6170, USA
    West J Nurs Res 30:928-42. 2008
    Poor adjustment to diabetes in older African American women may result from uncertainty, stemming from a lack of information about self-care activities, a complexity of self-care activities, comorbid conditions, and a lack of resources...
  92. ncbi Multi-scale strategies for the monitoring of freshwater cyanobacteria: reducing the sources of uncertainty
    Ramsy Agha
    Departamento de Biologia, C Darwin 2, Universidad Autonoma de Madrid, 28049 Cantoblanco, Spain
    Water Res 46:3043-53. 2012
    ..heterogeneities in both cyanobacterial distribution (remote sensing) and MC concentrations (subpopulation analysis) and thereby reduce the main sources of uncertainty in the assessment of the risks associated to bloom events.
  93. ncbi Making conservation decisions under uncertainty for the persistence of multiple species
    Emily Nicholson
    The Ecology Centre, School of Integrative Biology, University of Queensland, St Lucia, Queensland 4072, Australia
    Ecol Appl 17:251-65. 2007
    ..given the associated uncertainties? We use information-gap decision theory to explore the impact of parameter uncertainty on the conservation decision when planning for the persistence of multiple species...
  94. ncbi Uncertainty and anticipation in anxiety: an integrated neurobiological and psychological perspective
    Dan W Grupe
    Departments of Psychiatry and Psychology, Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin Madison, 1500 Highland Avenue, Madison, Wisconsin 53705, USA
    Nat Rev Neurosci 14:488-501. 2013
    b>Uncertainty about a possible future threat disrupts our ability to avoid it or to mitigate its negative impact and thus results in anxiety...
  95. ncbi Investigating the construct validity of intolerance of uncertainty and its unique relationship with worry
    Kristin Buhr
    Department of Psychology py 170, Concordia University, 7141 Sherbrooke Street West, Montreal, Que, Canada H4B 1R6
    J Anxiety Disord 20:222-36. 2006
    Although recent findings suggest that intolerance of uncertainty is a fundamental construct involved in excessive worry, additional research is required to further establish the construct validity of intolerance of uncertainty and ..
  96. pmc Risky business: the neuroeconomics of decision making under uncertainty
    Michael L Platt
    Center for Neuroeconomic Studies, Room B243F LSRC Building, Duke University, Durham, North Carolina 27708 0999, USA
    Nat Neurosci 11:398-403. 2008
    Many decisions involve uncertainty, or imperfect knowledge about how choices lead to outcomes. Colloquial notions of uncertainty, particularly when describing a decision as 'risky', often carry connotations of potential danger as well...
  97. ncbi Are patterns of density dependence in the Global Population Dynamics Database driven by uncertainty about population abundance?
    Jonas Knape
    Department of Environmental Science, Policy and Management, University of California, Berkeley, Berkeley, CA 94720, USA
    Ecol Lett 15:17-23. 2012
    ..A major difficulty with assessing density dependence from time series is that uncertainty in population abundance estimates can cause strong bias in both tests and estimates of strength...
  98. pmc The brain network of expectancy and uncertainty processing
    Andres Catena
    Departamento de Psicologia Experimental, Universidad de Granada, Granada, Spain
    PLoS ONE 7:e40252. 2012
    ..The uncertainty hypothesis we present here postulates that the SPN is linked to control-related areas in the prefrontal cortex ..
  99. ncbi The human relevant potency threshold: reducing uncertainty by human calibration of cumulative risk assessments
    C J Borgert
    Applied Pharmacology and Toxicology, Inc, Gainesville, FL, USA
    Regul Toxicol Pharmacol 62:313-28. 2012
    ..The proposed approach recommends application of independent action for phthalates and other chemicals with potential anti-androgenic properties at current human exposure levels...
  100. pmc The known unknowns: neural representation of second-order uncertainty, and ambiguity
    Dominik R Bach
    Wellcome Trust Centre for Neuroimaging, University College London, London WC1N 3BG, United Kingdom
    J Neurosci 31:4811-20. 2011
    Predictions provided by action-outcome probabilities entail a degree of (first-order) uncertainty. However, these probabilities themselves can be imprecise and embody second-order uncertainty...
  101. ncbi Doubly distributional population codes: simultaneous representation of uncertainty and multiplicity
    Maneesh Sahani
    W M Keck Foundation Center for Integrative Neurosciences, Univ of Calif, San Francisco, CA 94143 0732, USA
    Neural Comput 15:2255-79. 2003
    Perceptual inference fundamentally involves uncertainty, arising from noise in sensation and the ill-posed nature of many perceptual problems...

Research Grants79

  1. Impact of the P479L Variant in CPT1A on Infant Mortality in Alaska
    David M Koeller; Fiscal Year: 2011
    ..The uncertainty regarding the appropriate treatment for infants with the c...
    Sarah Wagner; Fiscal Year: 2013
    ..cause of anger, despair, and hostility in post-conflict and post-disaster settings around the world is the uncertainty and lack of closure felt by families and communities whose loved ones disappeared without a trace...
  3. Effectiveness and Safety of Antithrombotic Strategies after Joint Replacement
    Elaine Hylek; Fiscal Year: 2013
    ..Specialty consensus guidelines differ leading to wide variation in clinical practice. Further heightening the uncertainty, higher all-cause mortality has been reported with use of potent anticoagulants and a pooled analysis of VTE ..
  4. Expanded Testing Methods for Elements and Metals in Animal Diagnostic Specimens
    Timothy Baszler; Fiscal Year: 2013
    ..accuracy, precision, selectivity, 22 limit of detection, limit of quantification, linearity, range, measurement uncertainty and 23 ruggedness...
  5. A rational approach to liver toxicity monitoring in methotrexate users
    Gabriela Schmajuk; Fiscal Year: 2013
    ..The uncertainty around the effects of frequent, untargeted toxicity monitoring represents a critical gap in knowledge that ..
  6. Robot-Assisted MRI-Guided Prostate Biopsy
    Dan Stoianovici; Fiscal Year: 2010
    ..These represent a daily problem for urologists managing the disease, create uncertainty and emotional stress for patients, and initiate a cascade of repeat testing and biopsies or overtreatment...
  7. Climate Change and Adverse Birth Outcomes: Assessing the Vulnerability of Pregnan
    Shao Lin; Fiscal Year: 2013
    ..K-means cluster analysis and Monte Carlo methods will be used to estimate weather factor clusters and uncertainty, respectively...
  8. Synergistic Roles of Adiponectin & PPARgamma in Beta-Cell Survival/Proliferation
    William L Holland; Fiscal Year: 2010
    ..Although there remains uncertainty about the molecular mechanism of action of TZDs, their effects likely involve upregulation of the adipocyte-..
  9. Predictors of sleep-dependent Memory Consolidation in Obstructive Sleep Apnea
    Ina E Djonlagic; Fiscal Year: 2013
    ..This diagnostic uncertainty can lead to a delay in disease recognition and treatment...
  10. Gender Selectivity to Colon Cancer Chemoprevention by NSAIDS
    RAMESH K contact WALI; Fiscal Year: 2010
    ..be linked to severe side-effects including ulcers, GI bleeding, hemorrhagic strokes etc, thereby causing some uncertainty in its use for preventing CRC for average risk use...
  11. Nanodiagnostics and Nanotherapeutics: Building Research Ethics and Oversight
    Susan M Wolf; Fiscal Year: 2010
    ..not yet adequately addressed key concerns including: difficulty predicting human response from animal data, uncertainty about how to assess risks, concerns about both participant and third-party safety both short-term and long-term,..
  12. Advanced Center for Latino and MH Systems Research
    Margarita Alegria; Fiscal Year: 2009
    ..and test a mixed methods approach to helping clinicians in public health psychiatric settings decrease clinical uncertainty by more accurately diagnosing patients with diverse cultural backgrounds and improving the matching of clinical ..
  13. Patient-centered approaches to diagnosing coronary heart disease
    JOSEPH ABIODUN LADAPO; Fiscal Year: 2013
    ..My interest in this area has grown out of my own personal experience with diagnostic uncertainty and also from my experience caring for patients evaluated for new, life-changing diseases...
  14. Individualized Treatment Strategies and Optimal Hematocrit Target for Complex Dia
    DENNIS JOSEPH COTTER; Fiscal Year: 2010
    ..Currently, there appears to be uncertainty in the nephrology community as to the optimal target hematocrit and epoetin dosing protocols for various ..
  15. Risk of Cancer in Incidental Findings Identified on Ultrasound Imaging
    Rebecca Smith-Bindman; Fiscal Year: 2013
    ..associated with theses findings is considered very low (the are almost entirely false positive diagnoses), uncertainty regarding their importance and clinical significance, and lack of management guidelines, often generated ..
  16. Competetive Renewal of MSM: Multiscale Studies of Segmentation in Vertebrates
    Claudio D Stern; Fiscal Year: 2013
    ..In part this uncertainty is due to the spatiotemporal complexity of somitogenesis, the number of mechanisms involved and the relative ..
  17. Barcoded Magnetic Beads for Rapid Tests of MRSA and Respiratory Viral Panels
    WINSTON Z HO; Fiscal Year: 2010
    ..cause illness, hospitalizations and deaths in the US during the normally flu-free summer months, there is some uncertainty about what the upcoming flu season might bring...
  18. Cancer Mortality among Military Participants at U.S. Nuclear Weapons Tests
    JOHN DUNNING BOICE; Fiscal Year: 2013
    ..New developments in statistical methodologies will be applied to account for the uncertainty in the estimated radiation doses...
  19. Developing Radiological Risk Communication Materials for Low-Literacy Populations
    SARAH B BASS; Fiscal Year: 2010
    ..literacy level;N=50) using psycho-physiological measures to assess the types of messages most likely to reduce uncertainty, decisional conflict, and physiological stress/tension and increase the willingness to comply with ..
    Yanle Hu; Fiscal Year: 2013
    ..With reduced uncertainty in tumor location, shape and motion, we will be able to provide more conformal treatments, reducing radiation ..
  21. Development and Validation of a Diagnostic Tool for Infant Head Injuries from Fal
    SUSAN SHEPS contact MARGULIES; Fiscal Year: 2010
    ..Some cases are easy to diagnose, but in cases of uncertainty accurate diagnosis of inflicted trauma is hindered by a lack of clarity regarding specific head injury ..
  22. DNA cross-linking by diepoxybutane
    Natalia Y Tretyakova; Fiscal Year: 2013
    ..activity of BD and afford new insights into the mechanisms of its mutagenicity and cytotoxicity, reducing the uncertainty in cancer risk assessment for human exposure to BD...
  23. Vitamin D Status in Relation to Incident Type 2 Diabetes and Cardiometabolic Risk
    Anastassios G Pittas; Fiscal Year: 2010
    ..interactions with weight change, race, physical activity, calcium intake and kidney function) and there is also uncertainty about its potential physiologic mechanisms of action in humans in relation to t2DM/CMD, which limits the value ..
  24. Longitudinal Impact of Antihypertensive Polypharmacy on Geriatric Syndromes
    Joseph T Hanlon; Fiscal Year: 2012
    ..However there is uncertainty regarding the generalizability of these beneficial findings to frail community dwelling older adults 85+ years ..
  25. Effects of Tobacco Exposure on Immune Responses
    Kari C Nadeau; Fiscal Year: 2013
    ..is surprisingly little understanding of tobacco smoke's specific impact on immune function and there is uncertainty about the mechanisms and full scope of its potential immunotoxicities...
  26. Genetics and biology of a viable mutant mouse with dystonic movements
    Kathleen J Sweadner; Fiscal Year: 2013
    ..The project is high-risk because of uncertainty about what genetic and neurological features will be discovered, and high-reward because the mouse's ..
  27. Safety and Effectiveness Evaluations for Diabetes
    DONALD READ MILLER; Fiscal Year: 2013
    ..Many new therapies for diabetes have emerged in recent years, but there continues to be concern and uncertainty regarding their safety and whether there are any incremental long term benefits...
  28. Biological Response to Air Quality Change in Beijing pre-, mid- and post-Olympics
    Lina Mu; Fiscal Year: 2013
    ..However, in vitro and in vivo studies can only provide indirect evidence due to the inherent uncertainty in the approaches when extrapolating their results to humans...
  29. Real-Time Reagent-Free Noninvasive Diagnosis of Tuberculosis
    Payam Nahid; Fiscal Year: 2013
    ..Undiagnosed cases unwittingly continue to transmit disease, threatening public health. In the US, the uncertainty in diagnosis, and the absence of sensitive, specific, and rapid tests, results in significant increases in ..
  30. Mitochondrial DNA repair agents for acute lung injury
    Mark N Gillespie; Fiscal Year: 2012
    ..of ALI/ARDS which tends to obfuscate design and interpretation of clinical trials, and partly to the scientific uncertainty about molecular targetsof anti-oxidant drug action...
  31. Trajectories of Kidney Dysfunction in Older Adults with Chronic Kidney Disease
    ..Furthermore, qualitative work has suggested that uncertainty about the expected course of CKD appears to be an important concern among both patients and providers...
  32. Environment, Psychosocial Stress and Self-regulatory Development
    SARA BURR JOHNSON; Fiscal Year: 2013
    ..Competent regulatory functioning allows individuals to control impulses, manage arousal and uncertainty, and delay short-term gratification in favor of longer-term goals...
  33. CFFONE: A Cell Phone Support Program for Adolescents with Cystic Fibrosis
    KEVIN F DAWKINS; Fiscal Year: 2010
    ..CF can cause a host of social-emotional stressors, including uncertainty about the future, poor self-image, low self-esteem, and frustration with delayed growth/maturation all of which ..
  34. Disorders of Sex Development: Platform for Basic and Translational Research
    ERIC J VILAIN; Fiscal Year: 2013
    ..For families, the birth of a child with a DSD, and the accompanying uncertainty about future psychological and sexual development, is believed to be extraordinarily stressful...
  35. Automatic Detection of Critical Dermoscopy Features for Basal Cell Carcinoma
    William V Stoecker; Fiscal Year: 2010
    ..designed to solve problems every healthcare consumer has encountered- too long a wait to get specialty care, uncertainty about the diagnosis when one does get the care, and too much overall expenditure in providing the care...
  36. Mindfulness Based Stress Reduction for Psycho-Immune Dysregulation in Cancer
    Herbert L Mathews; Fiscal Year: 2012
    ..diagnosis and treatment cause psychosocial distress, disrupted social relationships, anxiety, poor sleep, uncertainty, and fear of cancer recurrence...
  37. Etiologic Role of HPV in Keratinocyte Carcinomas
    Margaret Karagas; Fiscal Year: 2009
    ..e., squamous cell carcinoma (SCC) of the skin) is unclear. Part of the uncertainty stems from the lack of large, population-based studies...
  38. Methods for modeling air pollution effects on exhaled biomarkers
    SANDRAH PROCTOR ECKEL; Fiscal Year: 2013
    ..methods employed in epidemiologic studies with multiple flows FeNO use data inefficiently and ignore the uncertainty in the estimation of the parameters...
    Huei Ting Tsai; Fiscal Year: 2013
    ..Additionally, there is uncertainty about the optimal application of ADT - continuously, or intermittently with off- treatment periods if a patient&..
  40. Assessing the Cumulative Climate-Related Health Risks in the Eastern U.S.
    Yang Liu; Fiscal Year: 2011
    ..to verify simulated current exposures, and analyze the impact of each analytical step to the overall uncertainty in risk estimates...
    Robert D Gregg; Fiscal Year: 2013
    ..independently control different joints and time periods of the gait cycle, limiting robustness to environmental uncertainty and requiring clinicians to spend significant amounts of time tuning each control model to the individual...
  42. Comparative and Cost-Effectiveness of Preventing HPV-Related Diseases
    JANE JOOYUN KIM; Fiscal Year: 2013
    ..the best available data;evaluate the health and economic consequences of alternative strategies;explore the uncertainty around their outcomes;explicitly quantify the tradeoffs associated with different approaches;and inform timely ..
  43. Auditory Processing of Stochastic FM in Relationship to Speech Perception
    STANLEY E SHEFT; Fiscal Year: 2011
    ..Incorporating stimulus uncertainty-a fundamental aspect of natural speech-all proposed psychoacoustic measures determine ability to discriminate ..
  44. Chemotherapy Near Death: Modifiable Factors and Outcomes in Ovarian Cancer
    Alexi Wright; Fiscal Year: 2013
    ..Rates are highest in ovarian cancer where patients may respond to multiple lines of chemotherapy, increasing uncertainty about when to stop treatment...
  45. Space-time Modeling for Linking Climate Change,Pollutant Exposure, Built Environm
    Montserrat Fuentes; Fiscal Year: 2013
    ..stressors, climatic variables, and health outcomes, while taking into account different sources of uncertainty in models and data...
  46. High Performance Validation and Classification of Metagenomic Ribosomal-RNA Seque
    Daniel Frank; Fiscal Year: 2011
    ..Calculation of position-specific measures of alignment uncertainty allows detection of poorly aligned sequences and alignment positions, which can be removed prior to downstream ..
  47. Penn Center for ELSI Research in Emerging Genetic Technologies in Health Care
    Reed E Pyeritz; Fiscal Year: 2012
    ..However, many genetic technologies increase uncertainty and confusion in the minds of patients, relatives, doctors, health insurers and others...
  48. Uncertainty and stimulant self-administration
    PAUL R VEZINA; Fiscal Year: 2013
    Liise Anne Pirofski; Fiscal Year: 2010
    ..The emergence of non-vaccine STs, uncertainty as to whether pneumococcal capsular polysaccharide (PPS) vaccines prevent pneumonia in adults, and the ..
  50. MR Angiography and Renography for Renovascular Disease
    Vivian S Lee; Fiscal Year: 2013
    ..The inability to differentiate RVD from incidental RAS has also contributed to the widespread uncertainty treatment, and lack of a sensitive test for detecting individual kidney response has further limited clinical ..
  51. Comparative effectiveness of ECG screening in children with Attention Deficit Hyp
    Laurel K Leslie; Fiscal Year: 2010
    ..In addition, decision analysis permits quantification of the impact of uncertainty accompanying the available data that may affect estimates of the tradeoffs between different screening and ..
  52. The Impact of Genetic Variability on Human Susceptibility to Chlorpyrifos
    ALICE LANGFORD CRANE; Fiscal Year: 2013
    ..current risk assessment efforts, which rely heavily on animal data and use population- driven paradigms with uncertainty factors used to account for poorly understood variability among individuals...
  53. Novel Influenza A Nanovaccines for Broad Cross Protection
    Baozhong Wang; Fiscal Year: 2013
    ..matched viruses, major limitations of current vaccines are the need to produce new vaccines every season, the uncertainty in choice of the correct strains, and the inability to prevent a new influenza pandemic...
  54. Origin of CD5+ B cell Lymphoma/Leukemia in Mice
    Kyoko Hayakawa; Fiscal Year: 2013
    ..Precise definition of CLL has been difficult due to lack of identification of key cytogenetic abnormalities and uncertainty over its cellular origins and pathogenesis...
  55. 4D Robust Optimization in Intensity-Modulated Proton Therapy
    Wei Liu; Fiscal Year: 2013
    ..Sources of uncertainty include tumor shrinkage, weight loss, variation in patient setup, respiratory motion, uncertainties in CT ..
  56. Translational Research Cancer Centers Consortium Annual Meeting
    Gregory B Lesinski; Fiscal Year: 2012
    ..This is especially important due to the uncertainty of institutional and corporate donations in the current financial climate...
  57. Polyploidy, aneuploidy and genome stability
    DAVID S PELLMAN; Fiscal Year: 2013
    ..Is it beneficial, detrimental, or a completely neutral passenger phenomenon during tumor development? The uncertainty about the contribution of aneuploidy to tumorigenesis is largely fueled by the paucity of mechanisms explaining ..
  58. A Probabilistic Pose Estimation Algorithm for 3D Motion Capture Data
    W Scott Selbie; Fiscal Year: 2011
    ..The current pose estimation algorithms were not designed to incorporate models of soft tissue artifact. Uncertainty in data (e.g...
  59. Activation and Signaling Mechanism of the RET Tyrosine Kinase Receptor
    JENNIFER MARIE CHOW; Fiscal Year: 2013
    ..These questions include addressing the difficult and longstanding uncertainty concerning whether GF receptors function by ligand-induced receptor dimerization, or alternatively by causing a ..
  60. New Avenues in GPIHBP1 Research
    Anne Beigneux; Fiscal Year: 2012
    ..These findings left me with uncertainty regarding whether the in vitro assays of GPIHBP1 were truly reliable indicators of GPIHBP1 function in vivo...
  61. Climate change and heat-related morbidity among vulnerable populations in Atlanta
    Stefanie Ebelt Sarnat; Fiscal Year: 2013
    ..regarding the current and future health impacts of heat, including assessment of sensitive subpopulations and uncertainty quantification in health impact projections...
  62. Stereotyping in medical student decision-making: presence, origins and solutions
    Robert L Williams; Fiscal Year: 2013
    ..and determinants of racial and gender biases in medical decision-making under conditions of scientific uncertainty of senior medical students...
    Reginald Valdez; Fiscal Year: 1999
    ..There was some uncertainty as to the extent of the problem of acute anaplasmosis infection in cattle and how the research findings might ..
    Robert Kusy; Fiscal Year: 2002
    ..Unfortunately the uncertainty of frictional forces complicates the practitioner's best efforts to move teeth...
  65. Risk of Cancer with Incidental Findings Identified on Ultrasound Imaging
    Rebecca Smith Bindman; Fiscal Year: 2010
    ..Although the risk of pathology associated with these lesions is considered low, uncertainty regarding their clinical significance and lack of guidelines for their management leads to extensive further ..
    JoAnne Youngblut; Fiscal Year: 2001
    ..a child suffers an accidental injury, families are suddenly faced with fears about the child's survival and uncertainty about the child's future...
  67. Implementation of a Mammography Reminder System in a Healthcare Network
    Roger Luckmann; Fiscal Year: 2009
    ..However, MRCS adoption faces many barriers including uncertainty about the roles of primary care practices, managed care organizations, and integrated healthcare networks (IHN),..
  68. Optimizing HIV Care in Less Developed Countries
    KENNETH ALAN FREEDBERG; Fiscal Year: 2012
    ..However, substantial uncertainty persists regarding optimal treatment strategies, the cost of second- and third-line antiretroviral treatment, ..
  69. Aging, Social Interdependence and Wisdom in the U.S. and Japan
    Richard E Nisbett; Fiscal Year: 2010
    ..dialectic reasoning, recognition of uncertainty, and context-dependent learning...
  70. CFFONE: A Cell Phone Support Program for Teens with Cystic Fibrosis
    Kevin Dawkins; Fiscal Year: 2007
    ..CF can cause a host of social-emotional stressors, including uncertainty about the future, poor self-image, low self-esteem, and frustration with delayed growth/maturation all of which ..
  71. Compensating for Uncertainty Biases in Health Risk Judgments
    SCOTT D FERSON; Fiscal Year: 2010
    ..The first issue is that there is usually uncertainty about the data arising from sampling error due to limited sample sizes, random measurement error, and a variety ..
  72. Stem Cells as Delivery Vehicles and Imaging Probes for Glioma Gene Therapy
    Syed Ali; Fiscal Year: 2009
    ..therapy (followed by adjuvant chemotherapy), which form the standard practice, very often fail because of uncertainty in delineating the margin of the tumor...
  73. Seeing through the Ears
    Alvaro Pascual Leone; Fiscal Year: 2006
    ..taking into account the major constraints imposed by both the human auditory system and the frequency-time uncertainty relation (The vOICe, U.S. Patent 5,097,326)...
  74. Mental Health Services in NY after WTC Disaster
    Joseph Boscarino; Fiscal Year: 2004
    ..Adding to the anxiety and uncertainty in the NYC is the economic uncertainty created by this disaster and the ongoing threat of future terrorism...
  75. Remittances and Risk: Evidence from Mexican Migrants
    Catalina Amuedo Dorantes; Fiscal Year: 2005
    ..rich cross-sectional dataset to study remittances to Mexico from the United States and to explore how risk and uncertainty affect the volume of remittances sent by individual workers to their families...
  76. Timely End-of-Life Communication to Parents of Children with Brain Tumors
    VERNA LEE FERGUSON; Fiscal Year: 2010
    ..care and end of life care (PC/EOL) decisions for these children, and they suffer from emotional distress, uncertainty about available options, decisional regret, false hope that focuses on cure rather than palliation, and ..
  77. Uncertainty and Watchful Waiting in Chronic Hepatitis C
    Donald Bailey; Fiscal Year: 2005
    ..We will also examine the associations of demographic variables, illness markers, and illness uncertainty with these trajectories. The specific aims are to: 1) identify potentially distinct classes of trajectories (e...
    Laurel Northouse; Fiscal Year: 2005
    ..outcomes (better family communication, higher self-efficacy, more problem-focused coping, and less threat, uncertainty, and hopelessness) and improve the distal clinical outcome, better quality of life, in a culturally and ..
  79. Impact of Health IT on Primary Care Work-flow and Financial Measures
    NEIL FLEMING; Fiscal Year: 2009
    ..outcome measures, contributing knowledge about the frequently cited perceived barriers to AEHR adoption of uncertainty regarding impact on productivity and financial performance during implementation, and uncertain financial and ..