Summary: The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.

Top Publications

  1. pmc Supervised risk predictor of breast cancer based on intrinsic subtypes
    Joel S Parker
    Lineberger Comprehensive Cancer Center, Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    J Clin Oncol 27:1160-7. 2009
  2. ncbi Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland
    P Lichtenstein
    Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden
    N Engl J Med 343:78-85. 2000
  3. ncbi What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes
    J Zhang
    Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 7510, USA
    JAMA 280:1690-1. 1998
  4. pmc Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
    Carl A Anderson
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Nat Genet 43:246-52. 2011
  5. ncbi Estimating the relative risk in cohort studies and clinical trials of common outcomes
    Louise Anne McNutt
    Department of Epidemiology, School of Public Health, University at Albany, State University of New York, Rensselaer, NY 12144, USA
    Am J Epidemiol 157:940-3. 2003
  6. ncbi Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis
    Evangelos C Rizos
    Lipid Disorders Clinic, Department of Internal Medicine, University Hospital of Ioannina, Ioannina, Greece
    JAMA 308:1024-33. 2012
  7. ncbi Genetic variations in the TGFβ signaling pathway, smoking and risk of colorectal cancer in a Chinese population
    Rong Zhong
    Department of Epidemiology and Biostatistics, and the Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
    Carcinogenesis 34:936-42. 2013
  8. ncbi General and abdominal adiposity and risk of death in Europe
    T Pischon
    Department of Epidemiology, German Institute of Human Nutrition, Potsdam Rehbruecke, Germany
    N Engl J Med 359:2105-20. 2008
  9. ncbi Association between nucleoside analogues and risk of hepatitis B virus–related hepatocellular carcinoma recurrence following liver resection
    Chun Ying Wu
    School of Medicine, National Yang Ming University, Taipei, Taiwan
    JAMA 308:1906-14. 2012
  10. ncbi Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    Circulation 116:39-48. 2007

Detail Information

Publications265 found, 100 shown here

  1. pmc Supervised risk predictor of breast cancer based on intrinsic subtypes
    Joel S Parker
    Lineberger Comprehensive Cancer Center, Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    J Clin Oncol 27:1160-7. 2009
    ..To improve on current standards for breast cancer prognosis and prediction of chemotherapy benefit by developing a risk model that incorporates the gene expression-based "intrinsic" subtypes luminal A, luminal B, HER2-enriched, and ..
  2. ncbi Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland
    P Lichtenstein
    Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden
    N Engl J Med 343:78-85. 2000
    ..The contribution of hereditary factors to the causation of sporadic cancer is unclear. Studies of twins make it possible to estimate the overall contribution of inherited genes to the development of malignant diseases...
  3. ncbi What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes
    J Zhang
    Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 7510, USA
    JAMA 280:1690-1. 1998
    ..population (>10%), the adjusted odds ratio derived from the logistic regression can no longer approximate the risk ratio...
  4. pmc Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
    Carl A Anderson
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Nat Genet 43:246-52. 2011
    ..We identified 29 additional risk loci (P < 5 × 10(-8)), increasing the number of ulcerative colitis-associated loci to 47...
  5. ncbi Estimating the relative risk in cohort studies and clinical trials of common outcomes
    Louise Anne McNutt
    Department of Epidemiology, School of Public Health, University at Albany, State University of New York, Rensselaer, NY 12144, USA
    Am J Epidemiol 157:940-3. 2003
    Logistic regression yields an adjusted odds ratio that approximates the adjusted relative risk when disease incidence is rare (<10%), while adjusting for potential confounders...
  6. ncbi Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis
    Evangelos C Rizos
    Lipid Disorders Clinic, Department of Internal Medicine, University Hospital of Ioannina, Ioannina, Greece
    JAMA 308:1024-33. 2012
    ..Considerable controversy exists regarding the association of omega-3 polyunsaturated fatty acids (PUFAs) and major cardiovascular end points...
  7. ncbi Genetic variations in the TGFβ signaling pathway, smoking and risk of colorectal cancer in a Chinese population
    Rong Zhong
    Department of Epidemiology and Biostatistics, and the Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
    Carcinogenesis 34:936-42. 2013
    Recent genome-wide association studies (GWAS) have reported multiple risk loci associated with risk of colorectal cancer (CRC), some of which are involved in the transforming growth factor beta (TGFβ) signaling pathway...
  8. ncbi General and abdominal adiposity and risk of death in Europe
    T Pischon
    Department of Epidemiology, German Institute of Human Nutrition, Potsdam Rehbruecke, Germany
    N Engl J Med 359:2105-20. 2008
    ..BMI, the weight in kilograms divided by the square of the height in meters) to assess the association of adiposity with the risk of death, but few have examined whether the distribution of body fat contributes to the prediction of death.
  9. ncbi Association between nucleoside analogues and risk of hepatitis B virus–related hepatocellular carcinoma recurrence following liver resection
    Chun Ying Wu
    School of Medicine, National Yang Ming University, Taipei, Taiwan
    JAMA 308:1906-14. 2012
    ..Tumor recurrence is a major issue for patients with hepatocellular carcinoma (HCC) following curative liver resection...
  10. ncbi Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    Circulation 116:39-48. 2007
    Visceral adipose tissue (VAT) compartments may confer increased metabolic risk. The incremental utility of measuring both visceral and subcutaneous abdominal adipose tissue (SAT) in association with metabolic risk factors and underlying ..
  11. ncbi Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a meta-analysis
    David Preiss
    BHF Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Pl, Glasgow G12 8TA, Scotland, United Kingdom
    JAMA 305:2556-64. 2011
    A recent meta-analysis demonstrated that statin therapy is associated with excess risk of developing diabetes mellitus.
  12. pmc Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach
    Anna Floegel
    Department of Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Diabetes 62:639-48. 2013
    Metabolomic discovery of biomarkers of type 2 diabetes (T2D) risk may reveal etiological pathways and help to identify individuals at risk for disease...
  13. ncbi Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial
    Jacques E Rossouw
    Division of Women s Health Initiative, National Heart, Lung, and Blood Institute, 6705 Rockledge Dr, One Rockledge Ctr, Suite 300, Bethesda, MD 20817
    JAMA 288:321-33. 2002
    ..Despite decades of accumulated observational evidence, the balance of risks and benefits for hormone use in healthy postmenopausal women remains uncertain...
  14. ncbi Risk of ischemic heart disease in women after radiotherapy for breast cancer
    Sarah C Darby
    Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom
    N Engl J Med 368:987-98. 2013
    Radiotherapy for breast cancer often involves some incidental exposure of the heart to ionizing radiation. The effect of this exposure on the subsequent risk of ischemic heart disease is uncertain.
  15. ncbi Urinary sodium and potassium excretion and risk of cardiovascular events
    Population Health Research Institute, Hamilton General Hospital, McMaster University, 237 Barton St E, Third Floor, Hamilton, ON, L8L 2X2, Canada
    JAMA 306:2229-38. 2011
    The precise relationship between sodium and potassium intake and cardiovascular (CV) risk remains uncertain, especially in patients with CV disease.
  16. pmc Social relationships and mortality risk: a meta-analytic review
    Julianne Holt-Lunstad
    Department of Psychology, Brigham Young University, Provo, Utah, United States of America
    PLoS Med 7:e1000316. 2010
    ..The quality and quantity of individuals' social relationships has been linked not only to mental health but also to both morbidity and mortality...
  17. pmc Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adults
    Elizabeth Selvin
    Department of Epidemiology and the Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21287, USA
    N Engl J Med 362:800-11. 2010
    ..Fasting glucose is the standard measure used to diagnose diabetes in the United States. Recently, glycated hemoglobin was also recommended for this purpose...
  18. pmc Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
    Chia Chen Liu
    Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian 361005, China
    Nat Rev Neurol 9:106-18. 2013
    ..APOE polymorphic alleles are the main genetic determinants of Alzheimer disease (AD) risk: individuals carrying the ε4 allele are at increased risk of AD compared with those carrying the more common ε3 ..
  19. pmc A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk
    Lena J Chin
    Department of Molecular, Yale University, New Haven, Connecticut 06520, USA
    Cancer Res 68:8535-40. 2008
    Lung cancer is the leading cause of cancer deaths worldwide, yet few genetic markers of lung cancer risk useful for screening exist...
  20. ncbi Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study
    B Fisher
    National Surgical Adjuvant Breast and Bowel Project, Allegheny University of the Health Sciences, Pittsburgh, PA 15212 5234, USA
    J Natl Cancer Inst 90:1371-88. 1998
    ..To test this hypothesis, the National Surgical Adjuvant Breast and Bowel Project initiated the Breast Cancer Prevention Trial (P-1) in 1992...
  21. ncbi Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women
    Børge G Nordestgaard
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
    JAMA 298:299-308. 2007
    ..Elevated nonfasting triglycerides indicate the presence of remnant lipoproteins, which may promote atherosclerosis...
  22. ncbi Dietary cadmium exposure and risk of postmenopausal breast cancer: a population-based prospective cohort study
    Bettina Julin
    Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Cancer Res 72:1459-66. 2012
    ..However, no prospective studies of cadmium exposure and breast cancer risk have been reported...
  23. ncbi Greater whole-grain intake is associated with lower risk of type 2 diabetes, cardiovascular disease, and weight gain
    Eva Qing Ye
    Program on Genomics and Nutrition, School of Public Health, University of California, Los Angeles, CA, USA
    J Nutr 142:1304-13. 2012
    ..study was to systematically examine longitudinal studies investigating whole-grain and fiber intake in relation to risk of type 2 diabetes (T2D), cardiovascular disease (CVD), weight gain, and metabolic risk factors...
  24. pmc Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21
    Albert Tenesa
    Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and MRC Human Genetics Unit, Edinburgh EH4 2XU, UK
    Nat Genet 40:631-7. 2008
    In a genome-wide association study to identify loci associated with colorectal cancer (CRC) risk, we genotyped 555,510 SNPs in 1,012 early-onset Scottish CRC cases and 1,012 controls (phase 1)...
  25. ncbi Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions
    A L Cheng
    Department of Internal Medicine, National Taiwan University College of Medicine, Taipei
    Anticancer Res 21:2895-900. 2001
    ..This prospective phase-I study evaluated these issues of curcumin in patients with one of the following five high-risk conditions: 1) recently resected urinary bladder cancer; 2) arsenic Bowen's disease of the skin; 3) uterine ..
  26. ncbi Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study
    Francesco U S Mattace-Raso
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Circulation 113:657-63. 2006
    Arterial stiffness has been associated with the risk of cardiovascular disease in selected groups of patients...
  27. pmc HIV transmission risk through anal intercourse: systematic review, meta-analysis and implications for HIV prevention
    Rebecca F Baggaley
    Department of Infectious Disease Epidemiology, MRC Centre for Outbreak Analysis and Modelling, Faculty of Medicine, Imperial College London, Paddington, London, UK
    Int J Epidemiol 39:1048-63. 2010
    ..We assessed the per-act and per-partner HIV transmission risk from AI exposure for heterosexuals and MSM and its implications for HIV prevention.
  28. pmc Quantifying the number of pregnancies at risk of malaria in 2007: a demographic study
    Stephanie Dellicour
    Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, UK
    PLoS Med 7:e1000221. 2010
    Comprehensive and contemporary estimates of the number of pregnancies at risk of malaria are not currently available, particularly for endemic areas outside of Africa...
  29. pmc Dysfunctional adiposity and the risk of prediabetes and type 2 diabetes in obese adults
    Ian J Neeland
    Division of Cardiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8830, USA
    JAMA 308:1150-9. 2012
    The risk of type 2 diabetes mellitus is heterogeneous among obese individuals. Factors that discriminate prediabetes or diabetes risk within this population have not been well characterized...
  30. ncbi Intermittent preventive therapy for malaria during pregnancy using 2 vs 3 or more doses of sulfadoxine-pyrimethamine and risk of low birth weight in Africa: systematic review and meta-analysis
    Kassoum Kayentao
    Liverpool School of Tropical Medicine, Liverpool, United Kingdom
    JAMA 309:594-604. 2013
    ..However, 2 doses may not provide protection during the last 4 to 10 weeks of pregnancy, a pivotal period for fetal weight gain...
  31. pmc Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)
    Eric A Klein
    Department of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    JAMA 306:1549-56. 2011
    The initial report of the Selenium and Vitamin E Cancer Prevention Trial (SELECT) found no reduction in risk of prostate cancer with either selenium or vitamin E supplements but a statistically nonsignificant increase in prostate cancer ..
  32. ncbi A functional -77T>C polymorphism in XRCC1 is associated with risk of breast cancer
    Li Liu
    Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
    Breast Cancer Res Treat 125:479-87. 2011
    ..tested this hypothesis by examining the contribution of polymorphism in the regulatory region of XRCC1 -77T>C to risk of breast cancer in 995 patients and 1,004 controls...
  33. pmc Association between body-mass index and risk of death in more than 1 million Asians
    Wei Zheng
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA
    N Engl J Med 364:719-29. 2011
    ..Most studies that have evaluated the association between the body-mass index (BMI) and the risks of death from any cause and from specific causes have been conducted in populations of European origin...
  34. ncbi Lifetime risk for development of atrial fibrillation: the Framingham Heart Study
    Donald M Lloyd-Jones
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University Feinberg School of Medicine, 680 N Lake Shore Drive, Suite 1102, Chicago, IL, 60611, USA
    Circulation 110:1042-6. 2004
    Atrial fibrillation (AF) is the most common cardiac dysrhythmia and a source of considerable morbidity and mortality, but lifetime risk for AF has not been estimated.
  35. ncbi Risk of dementia in diabetes mellitus: a systematic review
    Geert Jan Biessels
    Department of Neurology, Rudolf Magnus Institute of Neurosciences, University Medical Center Utrecht, Netherlands
    Lancet Neurol 5:64-74. 2006
    ..This high risk included both Alzheimer's disease and vascular dementia (eight of 13 studies and six of nine studies respectively)...
  36. pmc Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia
    John E Lisman
    Department of Biology, Brandeis University, 415 South Street, Waltham, MA 02454, USA
    Trends Neurosci 31:234-42. 2008
    Many risk genes interact synergistically to produce schizophrenia and many neurotransmitter interactions have been implicated. We have developed a circuit-based framework for understanding gene and neurotransmitter interactions...
  37. pmc Hsa-miR-499 rs3746444 polymorphism contributes to cancer risk: a meta-analysis of 12 studies
    Man Tang Qiu
    The Fourth Clinical College of Nanjing Medical University, Nanjing, China
    PLoS ONE 7:e50887. 2012
    ..Since 2007, many studies have investigated the association between common SNPs located on hsa-miR-499 (rs3746444) and cancer risks; however, the results were inconclusive...
  38. ncbi Risk of myocardial infarction and stroke after acute infection or vaccination
    Liam Smeeth
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    N Engl J Med 351:2611-8. 2004
    There is evidence that chronic inflammation may promote atherosclerotic disease. We tested the hypothesis that acute infection and vaccination increase the short-term risk of vascular events.
  39. pmc Genome-wide association meta-analysis identifies new endometriosis risk loci
    Dale R Nyholt
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Nat Genet 44:1355-9. 2012
    ..Finally, we found a significant overlap in polygenic risk for endometriosis between the genome-wide association cohorts of European and Japanese descent (P = 8...
  40. pmc Investigation of relative risk estimates from studies of the same population with contrasting response rates and designs
    Nicole M Mealing
    The Sax Institute, Broadway NSW, Australia
    BMC Med Res Methodol 10:26. 2010
    There is little empirical evidence regarding the generalisability of relative risk estimates from studies which have relatively low response rates or are of limited representativeness...
  41. pmc The ecology of infectious disease: effects of host diversity and community composition on Lyme disease risk
    Kathleen LoGiudice
    Institute of Ecosystem Studies, Box AB, Millbrook, NY 12545, USA
    Proc Natl Acad Sci U S A 100:567-71. 2003
    ..We present evidence that supports a novel function of vertebrate biodiversity, the buffering of human risk of exposure to Lyme-disease-bearing ticks...
  42. ncbi Increased cardiometabolic risk is associated with increased TV viewing time
    Katrien Wijndaele
    Cancer Prevention Research Centre, School of Population Health, University of Queensland, Herston, Queensland, Australia
    Med Sci Sports Exerc 42:1511-8. 2010
    ..in self-reported television viewing time are associated with changes in continuous biomarkers of cardiometabolic risk (waist circumference, triglycerides, HDL-cholesterol, systolic and diastolic blood pressure, fasting plasma glucose,..
  43. ncbi How does stress increase risk of drug abuse and relapse?
    R Sinha
    Department of Psychiatry, Yale University School of Medicine, 1 Long Wharf, Box 18, New Haven, CT 06511, USA
    Psychopharmacology (Berl) 158:343-59. 2001
    ..Although clinical observations suggest that exposure to stress increases drug use, and are associated with craving and relapse in addicts, human research in this area is largely correlational and at times contradictory...
  44. ncbi Polygenes, risk prediction, and targeted prevention of breast cancer
    Paul D P Pharoah
    Department of Oncology, University of Cambridge, United Kingdom
    N Engl J Med 358:2796-803. 2008
    ..New developments in the search for susceptibility alleles in complex disorders provide support for the possibility of a polygenic approach to the prevention and treatment of common diseases...
  45. ncbi Overweight and obesity as determinants of cardiovascular risk: the Framingham experience
    Peter W F Wilson
    Boston University School of Medicine, 715 Albany St, Evans 204, Boston, MA 02118, USA
    Arch Intern Med 162:1867-72. 2002
    To our knowledge, no single investigation concerning the long-term effects of overweight status on the risk for hypertension, hypercholesterolemia, diabetes mellitus, and cardiovascular sequelae has been reported.
  46. ncbi Subclinical atrial fibrillation and the risk of stroke
    Jeff S Healey
    Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    N Engl J Med 366:120-9. 2012
    ..We evaluated whether subclinical episodes of rapid atrial rate detected by implanted devices were associated with an increased risk of ischemic stroke in patients who did not have other evidence of atrial fibrillation.
  47. ncbi Metformin and cancer risk in diabetic patients: a systematic review and meta-analysis
    Andrea Decensi
    Division of Medical Oncology Unit, EO Ospedali Galliera, Mura delle Cappuccine 14, 16128 Genoa, Italy
    Cancer Prev Res (Phila) 3:1451-61. 2010
    Metformin, an insulin-lowering agent, has been associated with decreased cancer risk in epidemiologic studies in diabetic patients...
  48. pmc Gait and cognition: a complementary approach to understanding brain function and the risk of falling
    Manuel Montero-Odasso
    Division of Geriatric Medicine, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada
    J Am Geriatr Soc 60:2127-36. 2012
    ..that gait assessments can provide a window into the understanding of cognitive function and dysfunction and fall risk in older people in clinical practice. To this end, the benefits of dual-task gait assessments (e.g...
  49. ncbi Effects of tamoxifen vs raloxifene on the risk of developing invasive breast cancer and other disease outcomes: the NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 trial
    Victor G Vogel
    Magee Womens Hospital, University of Pittsburgh School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213 3221, USA
    JAMA 295:2727-41. 2006
    Tamoxifen is approved for the reduction of breast cancer risk, and raloxifene has demonstrated a reduced risk of breast cancer in trials of older women with osteoporosis.
  50. ncbi Inflammation in atherosclerosis: from vascular biology to biomarker discovery and risk prediction
    René R S Packard
    Leducq Center for Cardiovascular Research, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Clin Chem 54:24-38. 2008
    ..Despite the irreplaceable utility of plasma lipid profiles in assessment of atherosclerotic risk, these profiles provide an incomplete picture...
  51. pmc Dietary flavonoid intakes and risk of type 2 diabetes in US men and women
    Nicole M Wedick
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 95:925-33. 2012
    ..Data from mechanistic studies support a beneficial effect of specific flavonoids on insulin sensitivity. However, few studies have evaluated the relation between intakes of different flavonoid subclasses and type 2 diabetes...
  52. ncbi Aspirin and cancer risk: a quantitative review to 2011
    C Bosetti
    Department of Epidemiology, Istituto di Ricerche Farmacologiche, Mario Negri, Milan, Italy
    Ann Oncol 23:1403-15. 2012
    Aspirin has been associated to a reduced risk of colorectal and possibly of a few other common cancers.
  53. pmc Metabolite profiling identifies pathways associated with metabolic risk in humans
    Susan Cheng
    Cardiology Division, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    Circulation 125:2222-31. 2012
    Although metabolic risk factors are known to cluster in individuals who are prone to developing diabetes mellitus and cardiovascular disease, the underlying biological mechanisms remain poorly understood.
  54. pmc Low-frequency HIV-1 drug resistance mutations and risk of NNRTI-based antiretroviral treatment failure: a systematic review and pooled analysis
    Jonathan Z Li
    Section of Retroviral Therapeutics, Brigham and Women s Hospital, Harvard Medical School, Harvard University, Boston, Massachusetts 02139, USA
    JAMA 305:1327-35. 2011
  55. ncbi Effect of dutasteride on the risk of prostate cancer
    Gerald L Andriole
    Division of Urology, Washington University School of Medicine in St Louis, St Louis, MO 63110, USA
    N Engl J Med 362:1192-202. 2010
    We conducted a study to determine whether dutasteride reduces the risk of incident prostate cancer, as detected on biopsy, among men who are at increased risk for the disease.
  56. pmc A world malaria map: Plasmodium falciparum endemicity in 2007
    Simon I Hay
    Malaria Public Health and Epidemiology Group, Centre for Geographic Medicine, Kenya Medical Research Institute University of Oxford Wellcome TrustCollaborative Programme, Nairobi, Kenya
    PLoS Med 6:e1000048. 2009
    ..to intervene against malaria requires a detailed understanding of the contemporary spatial distribution of malaria risk. It is exactly 40 y since the last global map of malaria endemicity was published...
  57. ncbi Neural systems responding to degrees of uncertainty in human decision-making
    Ming Hsu
    Division of Humanities and Social Sciences, 228 77, California Institute of Technology, Pasadena, CA 91125, USA
    Science 310:1680-3. 2005
    Much is known about how people make decisions under varying levels of probability (risk). Less is known about the neural basis of decision-making when probabilities are uncertain because of missing information (ambiguity)...
  58. ncbi Maternal obesity and risk of preterm delivery
    Sven Cnattingius
    Clinical Epidemiology Unit, T2, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    JAMA 309:2362-70. 2013
    ..Obesity increases the risk of preterm delivery, but the associations between overweight and obesity and subtypes of preterm delivery are not ..
  59. pmc A meta-analysis of depression during pregnancy and the risk of preterm birth, low birth weight, and intrauterine growth restriction
    Nancy K Grote
    University of Washington, Seattle, 98105, USA
    Arch Gen Psychiatry 67:1012-24. 2010
    Maternal depressive symptoms during pregnancy have been reported in some, but not all, studies to be associated with an increased risk of preterm birth (PTB), low birth weight (LBW), and intrauterine growth restriction (IUGR).
  60. pmc Ambient air pollution and the risk of acute ischemic stroke
    Gregory A Wellenius
    Center for Environmental Health and Technology, Brown University, Providence, RI 02912, USA
    Arch Intern Med 172:229-34. 2012
    ..5 μm in diameter [PM(2.5)]) and cardiovascular morbidity and mortality is well established. Whether PM(2.5) levels below current US National Ambient Air Quality Standards also increase the risk of ischemic stroke remains uncertain.
  61. pmc α-Linolenic acid and risk of cardiovascular disease: a systematic review and meta-analysis
    An Pan
    Department of Nutrition, Harvard School of Public Health, Harvard Medical School, Boston, MA 02115, USA
    Am J Clin Nutr 96:1262-73. 2012
    Prior studies of α-linolenic acid (ALA), a plant-derived omega-3 (n-3) fatty acid, and cardiovascular disease (CVD) risk have generated inconsistent results.
  62. ncbi Comparisons of the strength of associations with future type 2 diabetes risk among anthropometric obesity indicators, including waist-to-height ratio: a meta-analysis
    Satoru Kodama
    Department of Health Management Center, Mito Kyodo General Hospital, Ibaraki, Japan
    Am J Epidemiol 176:959-69. 2012
    The aim of this meta-analysis was to compare the association of waist-to-height ratio (WHtR) with risk of incident diabetes with the associations of 3 other conventional obesity indicators (body mass index (BMI), waist circumference (WC), ..
  63. pmc Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes
    David M Nathan
    N Engl J Med 353:2643-53. 2005
    Intensive diabetes therapy aimed at achieving near normoglycemia reduces the risk of microvascular and neurologic complications of type 1 diabetes...
  64. ncbi Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism
    Jakob Christensen
    Department of Neurology, Aarhus University Hospital, Norrebrogade 44, DK 8000 Aarhus C, Denmark
    JAMA 309:1696-703. 2013
    Valproate is used for the treatment of epilepsy and other neuropsychological disorders and may be the only treatment option for women of childbearing potential. However, prenatal exposure to valproate may increase the risk of autism.
  65. ncbi Common genetic variants in pre-microRNAs were associated with increased risk of breast cancer in Chinese women
    Zhibin Hu
    Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China
    Hum Mutat 30:79-84. 2009
    ..and rs3746444) in pre-miRNAs (hsa-mir-146a, hsa-mir-149, hsa-mir-196a2, and hsa-mir-499) with breast cancer risk in a case-control study of 1,009 breast cancer cases and 1,093 cancer-free controls in a population of Chinese ..
  66. ncbi Telomere length and risk of incident cancer and cancer mortality
    Peter Willeit
    Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    JAMA 304:69-75. 2010
    Telomeres are essential to preserve the integrity of the genome. Critically short telomeres lead to replicative cell senescence and chromosomal instability and may thereby increase cancer risk.
  67. ncbi Vitamin B6 and risk of colorectal cancer: a meta-analysis of prospective studies
    Susanna C Larsson
    Division of Nutritional Epidemiology, National Institute of Environmental Medicine, Karolinska Institutet, PO Box 210, SE 171 77 Stockholm, Sweden
    JAMA 303:1077-83. 2010
    Mounting evidence indicates that vitamin B(6), a coenzyme involved in nearly 100 enzymatic reactions, may reduce the risk of colorectal cancer.
  68. ncbi C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women
    P M Ridker
    Center for Cardiovascular Disease Prevention, and Division of Cardiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 342:836-43. 2000
    Since inflammation is believed to have a role in the pathogenesis of cardiovascular events, measurement of markers of inflammation has been proposed as a method to improve the prediction of the risk of these events.
  69. ncbi Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women
    Sandeep Bansal
    Donald W Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, Boston, MA 02215, USA
    JAMA 298:309-16. 2007
    ..Although triglyceride levels are typically obtained in the fasting state, postprandial hypertriglyceridemia may play an important role in atherosclerosis...
  70. pmc Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls
    Maria N Timofeeva
    International Agency for Research on Cancer, Lyon, France
    Hum Mol Genet 21:4980-95. 2012
    ..33, 6p21-6p22 and 15q25.1 associated with lung cancer risk. Several other genetic regions including variants of CHEK2 (22q12), TP53BP1 (15q15) and RAD52 (12p13) have been ..
  71. pmc Understanding the link between malaria risk and climate
    Krijn P Paaijmans
    Center for Infectious Disease Dynamics, Department of Entomology, Chemical Ecology Laboratory, Pennsylvania State University, University Park, PA 16802, USA
    Proc Natl Acad Sci U S A 106:13844-9. 2009
    ..within the mosquito is exquisitely temperature-sensitive, so that temperature is a major determinant of malaria risk. Epidemiological models are increasingly used to guide allocation of disease control resources and to assess the ..
  72. ncbi Flavonoid intake and risk of chronic diseases
    Paul Knekt
    National Public Health Institute, Helsinki, Finland
    Am J Clin Nutr 76:560-8. 2002
    ..Flavonoids are effective antioxidants and may protect against several chronic diseases...
  73. ncbi Mammographic density and the risk and detection of breast cancer
    Norman F Boyd
    Campbell Family Institute for Breast Cancer Research, Toronto, ON, Canada
    N Engl J Med 356:227-36. 2007
    Extensive mammographic density is associated with an increased risk of breast cancer and makes the detection of cancer by mammography difficult, but the influence of density on risk according to method of cancer detection is unknown.
  74. ncbi Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck
    Jay S Cooper
    New York University Medical Center, New York, USA
    N Engl J Med 350:1937-44. 2004
    Despite the use of resection and postoperative radiotherapy, high-risk squamous-cell carcinoma of the head and neck frequently recurs in the original tumor bed...
  75. ncbi Radiation dose associated with common computed tomography examinations and the associated lifetime attributable risk of cancer
    Rebecca Smith-Bindman
    Department of Radiology, University of California, San Francisco, 94115, USA
    Arch Intern Med 169:2078-86. 2009
    ..We sought to estimate the radiation dose associated with common CT studies in clinical practice and quantify the potential cancer risk associated with these examinations.
  76. ncbi Participation in cognitively stimulating activities and risk of incident Alzheimer disease
    Robert S Wilson
    Rush Alzheimer s Disease Center, 1645 W Jackson Blvd, Suite 675, Chicago, IL 60612, USA
    JAMA 287:742-8. 2002
    Frequent participation in cognitively stimulating activities has been hypothesized to reduce risk of Alzheimer disease (AD), but prospective data regarding an association are lacking.
  77. ncbi Blood levels of long-chain n-3 fatty acids and the risk of sudden death
    Christine M Albert
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215 1204, USA
    N Engl J Med 346:1113-8. 2002
    ..properties, and a randomized trial suggested that dietary supplements of n-3 fatty acids may reduce the risk of sudden death among survivors of myocardial infarction...
  78. pmc Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies
    A Antoniou
    Cancer Research U K Genetic Epidemiology Unit, Department of Public Health, University of Cambridge, Cambridge, United Kingdom
    Am J Hum Genet 72:1117-30. 2003
    ..Estimates based on multiple-case families may be enriched for mutations of higher risk and/or other familial risk factors, whereas risk estimates from studies based on cases unselected for family ..
  79. pmc Angiotensin-receptor blockade and risk of cancer: meta-analysis of randomised controlled trials
    Ilke Sipahi
    Harrington McLaughlin Heart and Vascular Institute, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Lancet Oncol 11:627-36. 2010
    ..approved for treatment of hypertension, heart failure, diabetic nephropathy, and, recently, for cardiovascular risk reduction...
  80. pmc ADHD medications and risk of serious cardiovascular events in young and middle-aged adults
    Laurel A Habel
    Division of Research, Kaiser Permanente Northern California, 2000 Broadway, Fifth Floor, Oakland, CA 94612, USA
    JAMA 306:2673-83. 2011
    ..These agents can increase heart rate and blood pressure, raising concerns about their cardiovascular safety...
  81. pmc Effects of vitamin D and calcium supplementation on pancreatic β cell function, insulin sensitivity, and glycemia in adults at high risk of diabetes: the Calcium and Vitamin D for Diabetes Mellitus (CaDDM) randomized controlled trial
    Joanna Mitri
    Division of Endocrinology, Diabetes, and Metabolism, Tufts Medical Center, Boston, MA 02111, USA
    Am J Clin Nutr 94:486-94. 2011
    A suboptimal vitamin D and calcium status has been associated with higher risk of type 2 diabetes in observational studies, but evidence from trials is lacking.
  82. ncbi A genome-wide association study identifies two new risk loci for Graves' disease
    Xun Chu
    State Key Laboratory of Medical Genomics, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
    Nat Genet 43:897-901. 2011
    ..Moreover, we identified strong associations of TSHR and major histocompatibility complex class II variants with persistently TRAb-positive Graves' disease...
  83. ncbi Risk of venous thromboembolism with the angiogenesis inhibitor bevacizumab in cancer patients: a meta-analysis
    Shobha Rani Nalluri
    Division of Medical Oncology, Department of Medicine, Stony Brook University, Stony Brook, New York 11794, USA
    JAMA 300:2277-85. 2008
    ..Concerns have arisen regarding the risk of venous thromboembolism with the novel antiangiogenic agent bevacizumab, a recombinant humanized monoclonal ..
  84. ncbi Adolescent BMI trajectory and risk of diabetes versus coronary disease
    Amir Tirosh
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 364:1315-25. 2011
    ..The association of body-mass index (BMI) from adolescence to adulthood with obesity-related diseases in young adults has not been completely delineated...
  85. pmc Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study
    Peter Broderick
    Institute of Cancer Research, Sutton, Surrey, United Kingdom
    Cancer Res 69:6633-41. 2009
    To explore the impact of common variation on the risk of developing lung cancer, we conducted a two-phase genome-wide association (GWA) study...
  86. ncbi Intussusception risk and health benefits of rotavirus vaccination in Mexico and Brazil
    Manish M Patel
    Centers for Disease Control and Prevention, 1600 Clifton Rd, MS A 47, Atlanta, GA 30333, USA
    N Engl J Med 364:2283-92. 2011
  87. ncbi The metabolic syndrome: the crossroads between rheumatoid arthritis and cardiovascular risk
    Elisa Gremese
    Division of Rheumatology, Catholic University of the Sacred Heart, Rome, Italy
    Autoimmun Rev 10:582-9. 2011
    ..Traditional CV risk factors seem to have the same prevalence in RA and non-RA patients, and thus do not fully explain the increased CV ..
  88. ncbi Serum bilirubin and risk of respiratory disease and death
    Laura J Horsfall
    Research Department of Primary Care and Population Health, University College London, Royal Free Hospital, Rowland Hill Street, London NW3 2PF, England
    JAMA 305:691-7. 2011
    Serum total bilirubin levels in healthy patients reflect genetic and environmental factors that could influence the risk of developing respiratory disease.
  89. ncbi Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study
    Rudi G J Westendorp
    Department of Gerontology and Geriatrics, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Am Geriatr Soc 57:1634-7. 2009
    To compare the risk of mortality of nonagenarian siblings with that of sporadic nonagenarians (not selected on having a nonagenarian sibling) and to compare the prevalence of morbidity in their offspring with that of the offsprings' ..
  90. ncbi Mapping the onset of psychosis: the Comprehensive Assessment of At-Risk Mental States
    Alison R Yung
    Department of Psychiatry, University of Melbourne, Melbourne, Australia
    Aust N Z J Psychiatry 39:964-71. 2005
    ..This paper describes an instrument, the Comprehensive Assessment of At-Risk Mental States (CAARMS), which has been designed for such a purpose...
  91. pmc Genetic variants in telomere-maintaining genes and skin cancer risk
    Hongmei Nan
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Hum Genet 129:247-53. 2011
    ..TERT-CLPTM1L locus which has been identified as a susceptibility locus to skin cancer in the previous GWAS, and the risk of skin cancer in a case-control study of Caucasians nested within the Nurses' Health Study (NHS) among 218 ..
  92. ncbi Sex hormones and risk of liver tumor
    L Giannitrapani
    Dipartimento di Medicina Clinica e Patologie Emergenti, Universita di Palermo, Palermo, Italy
    Ann N Y Acad Sci 1089:228-36. 2006
    ..The human liver expresses estrogen and androgen receptors and experimentally both androgens and estrogens have been implicated in stimulating hepatocyte proliferation and may act as liver tumor inducers or promoters...
  93. ncbi Genetic polymorphisms and breast cancer risk: evidence from meta-analyses, pooled analyses, and genome-wide association studies
    Sihua Peng
    Department of Pathology, Zhejiang University School of Medicine, Zhejiang, People s Republic of China
    Breast Cancer Res Treat 127:309-24. 2011
    ..Such studies have prompted an updated assessment of the associations between gene variants and breast cancer risk. We searched PubMed, Medline, and Web of Science and retrieved a total of 87 meta- and pooled analyses, which ..
  94. pmc Red meat consumption and risk of type 2 diabetes: 3 cohorts of US adults and an updated meta-analysis
    An Pan
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 94:1088-96. 2011
    The relation between consumption of different types of red meats and risk of type 2 diabetes (T2D) remains uncertain.
  95. pmc Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success
    Susan E Hiby
    Department of Pathology, University of Cambridge, Cambridge CB2 1QP, England, UK
    J Exp Med 200:957-65. 2004
    ..KIR (AA genotype) when the fetus possessed HLA-C belonging to the HLA-C2 group were at a greatly increased risk of preeclampsia...
  96. ncbi Bisphosphonate use and the risk of subtrochanteric or femoral shaft fractures in older women
    Laura Y Park-Wyllie
    Institute for Clinical Evaluative Sciences, and Li Ka Shing Knowledge Institute of St Michael s Hospital, 30 Bond St, Toronto, Ontario, M5B 1W8
    JAMA 305:783-9. 2011
    ..Oral bisphosphonates have become a mainstay of treatment, but concerns have emerged that long-term use of these drugs may suppress bone remodeling, leading to unusual fractures...
  97. ncbi Purine-rich foods, dairy and protein intake, and the risk of gout in men
    Hyon K Choi
    Rheumatology Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 350:1093-103. 2004
    Various purine-rich foods and high protein intake have long been thought to be risk factors for gout...
  98. ncbi X-ray repair cross-complementing group 1 (XRCC1) genetic polymorphisms and gastric cancer risk: A HuGE review and meta-analysis
    HuiPing Xue
    Department of Gastroenterology, Renji Hospital, Shanghai Institute of Gastrointestinal Diseases, School of Medicine, Shanghai Jiaotong University, People s Republic of China
    Am J Epidemiol 173:363-75. 2011
    ..1 gene (XRCC1) single nucleotide polymorphisms (SNPs) Arg194Trp, Arg280His, and Arg399Gln with gastric cancer risk, based on eligible studies retrieved from electronic databases for the period January 2000-December 2009...
  99. pmc Single nucleotide polymorphisms associated with risk for contralateral breast cancer in the Women's Environment, Cancer, and Radiation Epidemiology (WECARE) Study
    Sharon N Teraoka
    Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908 0717, USA
    Breast Cancer Res 13:R114. 2011
    ..polymorphisms (SNPs) in a number of genomic regions that have alleles associated with a significantly increased risk of breast cancer...
  100. pmc Association between smoking and risk of bladder cancer among men and women
    Neal D Freedman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Blvd, EPS 320, MSC 7232, Rockville, MD 20852, USA
    JAMA 306:737-45. 2011
    Previous studies indicate that the population attributable risk (PAR) of bladder cancer for tobacco smoking is 50% to 65% in men and 20% to 30% in women and that current cigarette smoking triples bladder cancer risk relative to never ..
  101. ncbi Fruit and vegetable intake in relation to risk of ischemic stroke
    K J Joshipura
    Department of Epidemiology, Harvard School of Public Health, Boston, Mass, USA
    JAMA 282:1233-9. 1999
    ..Few studies have evaluated the relationship between fruit and vegetable intake and cardiovascular disease...

Research Grants100

  1. Methodology of Phase I and II trials of anticancer CAM
    Andrew Vickers; Fiscal Year: 2004
  2. Angiogenesis and thalidomide therapy in multiple myeloma
    S Rajkumar; Fiscal Year: 2004
    ..This study offers a unique opportunity to serially study tumor cells and the tumor microenvironment following potential anti-angiogenic therapy. ..
  3. Treatment of Early Stage Multiple Myeloma
    S Rajkumar; Fiscal Year: 2006
    ..BM angiogenesis will be studied using immunostaining (IHC) for CD34 and an in vitro human angiogenesis assay. VEGF expression will be studied using IHC and quantitative RT-PCR. ..
    Richard Santen; Fiscal Year: 2009
    ..FTS, a novel mTOR inhibitor will be used in vitro to activate the stress kinase pathway and apoptosis. In vivo, FTS will be used to enhance estradiol induced apoptosis in nude mice. ..
    Scott Woods; Fiscal Year: 2004
    ..risperidone, quetiapine) is the claim that the atypical antipsychotic medications are associated with a lower risk for the development of tardive dyskinesia than are the older conventional drugs...
    Scott Woods; Fiscal Year: 2003
    ..Thus, we are proposing to add these aims. ..
  7. Epidemiology of Disturbed Sleep Among Adolescents
    Robert Roberts; Fiscal Year: 2006
    ..The second is analytic, in which there are two foci. The first analytic focus is to examine the role of risk and protective factors in the etiology of disordered sleep...
    ALAN TAIT; Fiscal Year: 2002
    ..abstract_text> ..
    Richard Santen; Fiscal Year: 2008
    ..A clinical trial in women, which is designed to specifically demonstrate that high dose estrogen induces tumor regression through the mechanism of apoptosis will be conducted. ..
  10. Enhancing the Prospective Prediction of Psychosis
    Scott Woods; Fiscal Year: 2007
    ..Accurate identification of schizophrenic psychosis risk offers what may be the field's best hope for developing more effective treatment strategies, including ..
    Leslie Myatt; Fiscal Year: 2006
    ..The confocal microscopy will provide information on cellular localization of receptors and the promoter analyses will reveal potential regulatory sites for control of expression of uterine receptors at parturition. ..
    William Shadel; Fiscal Year: 2001
    ..Support for this social cognitive model would advance an understanding of the mechanisms involved in smoking and cessation behaviors, and possible lead to developing interventions that will help increasing number of smokers to quit. ..
  13. Growth Factors and Colon Cancer
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
    ..IGF), growth hormones that appear to be important for colorectal cancer, are influenced by previously identified risk factors for colorectal cancer such as body size and physical activity...
  14. Adolescents' responses to anti-smoking PSAs
    William Shadel; Fiscal Year: 2006
    ..cognitive model that specifies how features of anti-smoking Public Service Announcements (PSAs) influence high risk smoking cognitions (i.e...
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2007
    ..e. p53, K-ras, and microsatellite instability). Differences in colon and rectal tumors will be compared. Additionally data from rectal tumors will be combined with that from colon tumors to define disease pathways. ..
  16. Evolution of Disease: Current patterns and future trends
    Matthew Keeling; Fiscal Year: 2006
    ..The types of trade-offs and constraints seen in the experimental systems can then be used to formulated more biologically mechanistic and more accurate computer models of disease evolution in higher organisms. ..
  17. Lymphoma in Autoimmune Disease: Consequence of Immune Suppression or Stimulation?
    Sasha Bernatsky; Fiscal Year: 2008
    ..assembled the largest-ever cohort of SLE patients and reported that these patients have an almost 4-fold increased risk of developing lymphoma...
  18. Vitamin D Intake and Breast Cancer Survival
    Michelle Holmes; Fiscal Year: 2005
    ..animal studies have linked either dietary intake of vitamin D, vitamin D blood levels, or sun exposure with reduced risk of breast cancer incidence or breast cancer mortality...
  19. Metabolic and Epidemiologic Evaluation of Choline and Betaine Intake
    Eunyoung Cho; Fiscal Year: 2008
    ..lower fasting plasma homocysteine levels in women and men and higher choline intake was associated with an elevated risk of colorectal adenoma in women...
  20. Evaluation of Biological Relevance of Choline Intake
    Eunyoung Cho; Fiscal Year: 2005
    ..We will also examine choline intake in relation to colorectal adenoma risk in the Nurses' Health Study, a large prospective study of women...
  21. Effect of 14 Underage Drinking Laws on Youthful Deaths
    James Fell; Fiscal Year: 2006
    ..abstract_text> ..
  22. The NonCancer Care of Elderly Colorectal Cancer Patients
    Laura Mae Baldwin; Fiscal Year: 2006
    ..abstract_text> ..
  23. Cancer Risks Attributable To Radiation from Pediatric CT
    David Brenner; Fiscal Year: 2006
    ..benefits of CT almost always far outweigh the small individual risks, but there is room to reduce the population risk, by reducing pediatric CT exposure settings, and by a somewhat more selective use of pediatric CT...
  24. High Stability Accelerator for Sub-Cellular Microbeam
    David Brenner; Fiscal Year: 2003
    ..We have considerably more demand for microbeam time than we can cope with, primarily because of limited physicist manpower. ..
    Laura Mae Baldwin; Fiscal Year: 2003
    ..Alternate methods of defining comorbidity and costs will be used to evaluate their utility in cancer research. ..
    David Brenner; Fiscal Year: 2002
    ..abstract_text> ..
  27. An Evaluation of the Night Restriction and Passenger Limitation Components of Gra
    James Fell; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  28. Effects of Light at Night on Circadian System in Nurses
    Eva Schernhammer; Fiscal Year: 2008
    ..Particularly, light exposure that occurs at night may have an adverse effect on cancer risk through suppression of melatonin, a hormone that is intimatelylinked with the circadian system and which may have ..
  29. Statistical Methods for Identifying Clonal Tumors
    Colin B Begg; Fiscal Year: 2011
  30. Preventing Alcohol Use Among African American Youths
    Gene Brody; Fiscal Year: 2009
    ..As in the original research, a multi-informant design that includes reports from adolescents, their friends, their primary caregivers, and their teachers will be used to collect the additional data. ..
  31. Modeling the Effect of Cigarette Advertising on Adolescent Smoking
    William G Shadel; Fiscal Year: 2010
    ..media channels stronger than the effect of exposure via a single channel? Are some groups of adolescents more at risk to the effects of cigarette advertising and marketing than others? What psychological processes mediate and ..
  32. Reduction of Annexin A5 in Antipholipid Pregnancy Loss
    JACOB RAND; Fiscal Year: 2010
    Peter Carroll; Fiscal Year: 2008
    ..In addition, members of a recently formed Prostate Cancer Advocacy Core will work with SPORE investigators to design, and implement optimal approaches to clinical trials. ..
  34. Gene-Specific Responses to Exercise in Discordant Twins
    Paul Williams; Fiscal Year: 2007
    ..DNA samples will be shared with other institutions to cross-validate gene associations identified from training studies or other designs. ..
  35. A Genome-Wide Association Study of Non-Hodgkin Lymphoma
    Christine F Skibola; Fiscal Year: 2010
    ..Once target genes are identified by pooled genotyping, the association of these loci with NHL risk will be verified and further investigated by individual genotyping...
  36. Mouse Allergen and Inner-City Asthma
    Elizabeth C Matsui; Fiscal Year: 2010
    Alberto Palloni; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  38. Prospective Risk and Protective Factors for Suicide and co-occurring Risk Behavio
    ..Previous studies have identified theoretically grounded and empirically validated risk and protective factors for suicide among adolescents and young adults (Borowsky et al...
  39. Reactive astrocytes from gliotic capsule
    J Marc Simard; Fiscal Year: 2007
    ..unreadable] [unreadable]..
    Maarten C Bosland; Fiscal Year: 2010
    ..arm (n = 126/arm) randomized, double-blind, placebo-controlled phase I I/I 11 clinical trial in men who are at high risk for prostate cancer recurrence after a radical prostatectomy with administration of soy protein isolate or a casein-..
  41. Visual Impairment, Treatment and Effects on the Elderly
    Frank Sloan; Fiscal Year: 2008
    ..Ten papers are anticipated for this four-year study. [unreadable] [unreadable]..
  42. Pharmacogenetics of the acute response to sulfonylurea and metformin treatment in
    Jose Florez; Fiscal Year: 2008
    ..propose to examine 1) the acute response to a sulfonylurea challenge (glipizide 5 mg orally) in 750 subjects at risk of diabetes or with early diabetes (on diet treatment alone), depending on genotype at KCNJ11 E23K and TCF7L2 ..
  43. Mouse Allergen and Asthma Intervention Trial
    Elizabeth Matsui; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  44. Host and Viral Genetic Variability in HBV Carriers
    Alison Evans; Fiscal Year: 2006
    Chronic carriers of hepatitis B virus (HBV) are at increased risk for hepatocellular carcinoma (HCC). Worldwide, however, the risk of HCC and other adverse outcomes varies substantially both between and within populations of HBV carriers...
  45. Dose-Volume Modeling of Late Rectal and Bladder Toxicity
    Susan Tucker; Fiscal Year: 2007
    ..RT, there is an increasing need to improve the quality of life among prostate cancer survivors by reducing the risk of normal-tissue toxicity...
  46. Aspartame Intake and the Risk of Cancer
    Eva Schernhammer; Fiscal Year: 2008
    ..Health Professionals Follow-up Study, with prospectively and repeatedly collected information on diet to assess the risk of cancer in relation to aspartame intake...
  47. True prevalence of pre-existing reverse transcriptase inhibitor resistance in tre
    Rafael Campo; Fiscal Year: 2008
    ..Most importantly, unrecognized resistance might impair the efficacy of antiretroviral therapy, and its timely identification could lead to better treatment outcomes. [unreadable] [unreadable] [unreadable]..
  48. Gene-Nutrient Interactions and Breast Cancer
    SUSAN STECK; Fiscal Year: 2007
    ..vegetable consumption and polymorphisms in GSTM 1, GSTT 1, GSTP 1 and CYP 1A 1 in relation to breast cancer risk in a large population-based case-control study; and 3) to examine the interaction in relation to breast cancer ..
  49. Neighborhoods and the Health of Elderly Americans
    Jeannette Rogowski; Fiscal Year: 2007
    ..Neighborhood characteristics, derived from the work of the Center's data core, will be merged with the individual level data at the census tract level...
  50. Validation of the EARTH Study Diet History Questionnaire
    Maureen Murtaugh; Fiscal Year: 2007
    ..traditional). [unreadable] [unreadable] [unreadable]..
  51. Tailored Web Program to Reduce At-Risk College Drinking
    C Raymond Bingham; Fiscal Year: 2009
    Great need is evident for effective interventions to prevent/reduce at-risk drinking (ARD;combinations of quantity and frequency that place one's health at risk) among underage college undergraduate students...
  52. HIV/STD Risk Behaviors in Methamphetamine User Networks
    Steven Shoptaw; Fiscal Year: 2007
    ..associations between drug involvement (methamphetamine user, other drug user, non-drug user), IDU status, sexual risk behavior (MSM, MSM/W, WSM), and HIV/STDs; (2) Evaluate the types of sexual partnerships and dynamics of the ..
  53. Conference on Aging in Developing Countries: Building Integrated Research Agendas
    Alberto Palloni; Fiscal Year: 2007
    ..As a consequence, this meeting is highly relevant for policy design not just for public health but also for policies related to labor force, income distribution, and pensions systems. [unreadable] [unreadable] [unreadable]..
  54. Adult Outcome of Attention Deficit Hyperactivity Disorder
    Joseph Biederman; Fiscal Year: 2007
    ..For these reasons, we expect the proposed work to clarify the course and outcome of ADHD. ..
  55. Liability Markers for Deficit Schizophrenia?
    L Hong; Fiscal Year: 2004
    ..We plan to use the preliminary data collected from this grant support to guide our full-scale search for phenotypic markers specifically associated with the liability for deficit schizophrenia and subsequent molecular genetic studies. ..
    Carol North; Fiscal Year: 2002
    ..Structural characteristics (organizational, management, and financing) data will be collected from service agencies at baseline to examine their impact on service use. ..
    Michael Irwin; Fiscal Year: 2003
    ..This study hypothesizes that older adults with major depression are at increased risk for reactivation of varicella-zoster virus (VZV) infection...
    J Simard; Fiscal Year: 2004
    ..proven deleterious effects on the cerebral circulation, Epidemiological evidence indicates that smoking elevates risk of stroke by promoting development of atherosclerosis, formation of multiple cerebral aneurysms, and vasospasm ..
    Barbara Klein; Fiscal Year: 2002
    ..common cataract type to precede lens extraction While older age and female gender are associated with increased risk, other factors have been found and still other, hypothesized to also be associated with risk, some positively and ..
  60. Family Clustering of Incidence & Progression of Cataract
    Barbara Klein; Fiscal Year: 2003
    ..factors, aggregate in families and whether families that display greater progression of cataracts are at greater risk of systemic morbidity, frailty and mortali1y...
    Laurence Boxer; Fiscal Year: 2003
    ..Specific AIM 3 will examine the cellular targets of ceramide and sphingosine actin during PMN phagocytosis, focusing primarily on activation of mitogen-activated kinase (MAPK), Raf kinase and how they are linked to phagosome generation. ..
    Dina Hirshfeld Becker; Fiscal Year: 2002
    ..The candidate proposes to build upon her experience studying behavioral inhibition as a risk factor for anxiety disorders by learning to apply this knowledge to benefit children at risk...
    Laurie Chassin; Fiscal Year: 2003
    The proposed project studies a centrally important question in substance use research-namely, how is risk transmitted across multiple generations? First, we follow children of alcoholics (COAs) and controls into adulthood to examine risk ..
  64. Mental Health Consequences of Bioterrorism
    Carol North; Fiscal Year: 2002
    ..As a result, mental health risks to individuals from bioterrorism are unpredictable because the risk follows unknown variables other than exposure that are not well understood...
    Lewis Landsberg; Fiscal Year: 2003
    ..This plan will not only meet national research needs in neurodegenerative diseases, but will lead to more efficient utilization of over $3M/year in direct costs provided to these six investigators by NIH. ..
    Leslie Myatt; Fiscal Year: 2002
    ..5. Expression of mRNA and protein for SOD isoforms, xanthine oxidase and the cytochrome b558 subunit of NADPH oxidase in normal and pathologic placental tissues using RT-PCR and immunohistochemistry. ..
    CHRISTOPHER LONIGAN; Fiscal Year: 2004
    ..children's emergent literacy skills and to use this knowledge to improve (a) early identification of children at risk for reading disabilities, (b) the understanding of the developmental and causal relations between preschool ..
    Davangere Devanand; Fiscal Year: 2001
    ..These clinical data will be important in improving the management of AD patients with behavioral complications. ..
  69. Pet Exposure, Allergy and Early Asthma in the Inner-City
    Matthew Perzanowski; Fiscal Year: 2005
    ..cockroach and mouse allergens, exposure to high concentrations of cat and dog allergens early in life decreases the risk of developing pet-specific IgE responses and allergic symptoms...
  70. 2006 Clinical Research Training Institute
    James George; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
    Michael Irwin; Fiscal Year: 2006
    ..abstract_text> ..
  72. A Method for Validating Gene - Disease Associations
    Colin Begg; Fiscal Year: 2004
    ..in relation to the underlying incidence rate of the cancer under study, the population frequency and the relative risk of the genotype...
    Joseph Biederman; Fiscal Year: 2002
    ..over a five-year neuropsychological functional and psychosocial disability and 4) the course and outcome of high risk siblings of ADHD probands...
    Joseph Biederman; Fiscal Year: 2001
    ..This finding suggests that preventive efforts focus on adolescence, a known risk period for the initiation of smoking...
  75. Views of Privacy of Genetic Information
    Robert Klitzman; Fiscal Year: 2005
    ..The aims of this study are thus 1) to explore views of privacy issues among individuals who are at risk of or have genetic disorders concerning privacy of genetic and other health information, threats to privacy, ..
  76. Minicomputer Upgrade for the Clinical Resarch Database
    Colin Begg; Fiscal Year: 2002
    ..This proposal is a request for funds to upgrade the hardware platform once again to maintain the performance of the system in the face of these rapidly increasing demands. ..
  77. Pain Medication Use & Risk Factors for Opioid Dependence
    Daniel Solomon; Fiscal Year: 2004
    ..Our goal is to use the results of the proposed research to inform a future intervention to improve opioid prescribing within this large pharmacy benefits program. ..
    Maarten Bosland; Fiscal Year: 2004
    ..abstract_text> ..
  79. Neuroinflammation in Cholesterol-Induced AD Pathogenesis
    Narayan Bhat; Fiscal Year: 2009
    ..The outcome of these studies should have implications for developing novel and effective anti- inflammatory treatments for AD. ..
    John Constantino; Fiscal Year: 2002
    ..If the SRS compares favorably with the ADI-R, the SRS could feasibly be used to study the genetics of autism by examining the genetic structure of autistic traits in whole populations. ..
    SANDRA HASSTEDT; Fiscal Year: 2009
    ..Nevertheless, the current application also proposes to develop new genetic models of disease risk, including a mode-of-inheritance free method...
  82. Adolescents' Exposure to Family and Community Violence
    Gayla Margolin; Fiscal Year: 2009
    ..outcomes (behavioral and psychological functioning;aggression toward others;academic achievement;and high-risk, health-compromising behaviors)...
    SANDRA HASSTEDT; Fiscal Year: 2002
    ..Cigarette smoking is the primary environmental factor that increases the risk of COPD, but other environmental factors have also been implicated...
  84. Pioglitazone in Alzheimer's Disease Progression
    David Geldmacher; Fiscal Year: 2003
    ..Comparison of mean differences (using last observation carried forward imputation techniques) and survival analyses will be employed to assess for group differences in clinical measures AD of progression. ..
  85. Improving Metabolic Control in Diabetic Young Children
    Claude Chemtob; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  86. Fordham Resident Alcohol Prevention Program
    Celia Fisher; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  87. Mood Worsening in Spring in Women with Depression and Tree-Pollen Allergy
    TEODOR POSTOLACHE; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
    Steven Cummings; Fiscal Year: 2002
    ..This Consortium will catalyze interactions between outstanding laboratory and clinical scientists that will lead to collaborative studies of the genetic determinants of longevity and frailty. ..
  89. Cardiovascular Risk 50 Years After Thymic Irradiation
    Michael Adams; Fiscal Year: 2007
    ..this proposal evaluating this cohort is in fact two studies: 1) the follow-up of the entire cohort evaluating the risk of clinical coronary artery disease events associated with radiotherapy and 2) a pilot study clinically evaluating ..
  90. Prenatal NSAID Use and Miscarriage
    De Kun Li; Fiscal Year: 2008
    unreadable] DESCRIPTION (provided by applicant): Recent reports have revealed an increased risk of spontaneous abortion associated with the use of non-steroidal anti-inflammatory drugs (NSAIDs) during pregnancy...
    TEODOR POSTOLACHE; Fiscal Year: 2009
    ..we proposed that the massive release of tree-pollen in spring, via mediators of inflammation, elevates the relative risk for suicide, by affecting individuals with vulnerability for allergies, depression, and suicide...
  92. Mechanism of Endotoxin's Effect On Allergy Risk
    Keoki Williams; Fiscal Year: 2008
    ..provided by applicant): A number of studies suggest that early exposure to endotoxin is associated with a lower risk of asthma and allergies. The overall objective of this research is to understand the mechanism of that effect...
  93. Defining the Clinical Significance of HbA1c Prior to the Onset of Diabetes
    Elizabeth Selvin; Fiscal Year: 2008
    ..We hypothesize that HbA1c is a valuable risk predictor in non- diabetic individuals of not only the onset of diabetes, but also the development of clinical ..
  94. Recall and Survivor Bias: Impact on SES-CVD Associations
    Kathryn Rose; Fiscal Year: 2009
  95. Prenatal MF Exposure & Miscarriage Risk Among Women
    De Kun Li; Fiscal Year: 2009
    ..concerns about exposure to high levels >=16 milligauss (mG)] of magnetic fields (MFs) during pregnancy and the risk of miscarriage...
  96. Non-Invasive Localization of Vulnerable Plaques
    Cynthia McCollough; Fiscal Year: 2009
  97. Combat Stress and Cardiovascular Risk Among Aging Men
    Kathryn Rose; Fiscal Year: 2007
    ..This is a first resubmission of Assignment Number 1 R21 HL080422-01 titled "Combat Stress and Cardiovascular Risk Among Aging Men"...
    Thomas Roth; Fiscal Year: 2003
    ..morbidity, and significance is emerging, little population-based information about the prevalence, consequences and risk factor's of EDS exists...