odds ratio

Summary

Summary: The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.

Top Publications

  1. ncbi Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study
    Salim Yusuf
    Population Health Research Institute, Hamilton General Hospital, 237 Barton Street East, Hamilton, Ontario, Canada L8L 2X2
    Lancet 364:937-52. 2004
  2. ncbi What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes
    J Zhang
    Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 7510, USA
    JAMA 280:1690-1. 1998
  3. ncbi The diagnostic odds ratio: a single indicator of test performance
    Afina S Glas
    Department of Clinical Epidemiology and Biostatistics, University of Amsterdam, Academic Medical Center, Post Office Box 22700, 100 DE Amsterdam, The Netherlands
    J Clin Epidemiol 56:1129-35. 2003
  4. ncbi A variant associated with nicotine dependence, lung cancer and peripheral arterial disease
    Thorgeir E Thorgeirsson
    deCODE Genetics, 101 Reykjavik, Iceland
    Nature 452:638-42. 2008
  5. ncbi Gender-based violence, relationship power, and risk of HIV infection in women attending antenatal clinics in South Africa
    Kristin L Dunkle
    Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA
    Lancet 363:1415-21. 2004
  6. ncbi A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25
    Rayjean J Hung
    International Agency for Research on Cancer IARC, Lyon 69008, France
    Nature 452:633-7. 2008
  7. ncbi What to add to nothing? Use and avoidance of continuity corrections in meta-analysis of sparse data
    Michael J Sweeting
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK
    Stat Med 23:1351-75. 2004
  8. ncbi Complement factor H variant increases the risk of age-related macular degeneration
    Jonathan L Haines
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Science 308:419-21. 2005
  9. ncbi Estimating the relative risk in cohort studies and clinical trials of common outcomes
    Louise Anne McNutt
    Department of Epidemiology, School of Public Health, University at Albany, State University of New York, Rensselaer, NY 12144, USA
    Am J Epidemiol 157:940-3. 2003
  10. ncbi Explaining heterogeneity in meta-analysis: a comparison of methods
    S G Thompson
    Department of Medical Statistics and Evaluation, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, U K
    Stat Med 18:2693-708. 1999

Research Grants

Detail Information

Publications284 found, 100 shown here

  1. ncbi Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study
    Salim Yusuf
    Population Health Research Institute, Hamilton General Hospital, 237 Barton Street East, Hamilton, Ontario, Canada L8L 2X2
    Lancet 364:937-52. 2004
    ..Therefore, the effect of such factors on risk of coronary heart disease in most regions of the world is unknown...
  2. ncbi What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes
    J Zhang
    Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 7510, USA
    JAMA 280:1690-1. 1998
    ..When the incidence of an outcome of interest is common in the study population (>10%), the adjusted odds ratio derived from the logistic regression can no longer approximate the risk ratio...
  3. ncbi The diagnostic odds ratio: a single indicator of test performance
    Afina S Glas
    Department of Clinical Epidemiology and Biostatistics, University of Amsterdam, Academic Medical Center, Post Office Box 22700, 100 DE Amsterdam, The Netherlands
    J Clin Epidemiol 56:1129-35. 2003
    ..Here we propose the use of the odds ratio as a single indicator of diagnostic performance...
  4. ncbi A variant associated with nicotine dependence, lung cancer and peripheral arterial disease
    Thorgeir E Thorgeirsson
    deCODE Genetics, 101 Reykjavik, Iceland
    Nature 452:638-42. 2008
    ..The findings provide a case study of a gene-environment interaction, highlighting the role of nicotine addiction in the pathology of other serious diseases...
  5. ncbi Gender-based violence, relationship power, and risk of HIV infection in women attending antenatal clinics in South Africa
    Kristin L Dunkle
    Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA
    Lancet 363:1415-21. 2004
    ..No study on women has yet assessed gender-based violence as a risk factor for HIV after adjustment for women's own high-risk behaviours, although these are known to be associated with experience of violence...
  6. ncbi A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25
    Rayjean J Hung
    International Agency for Research on Cancer IARC, Lyon 69008, France
    Nature 452:633-7. 2008
    ..Our results provide compelling evidence of a locus at 15q25 predisposing to lung cancer, and reinforce interest in nicotinic acetylcholine receptors as potential disease candidates and chemopreventative targets...
  7. ncbi What to add to nothing? Use and avoidance of continuity corrections in meta-analysis of sparse data
    Michael J Sweeting
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK
    Stat Med 23:1351-75. 2004
    ..To compare the performance of different meta-analysis methods for pooling odds ratios when applied to sparse event data with emphasis on the use of continuity corrections...
  8. ncbi Complement factor H variant increases the risk of age-related macular degeneration
    Jonathan L Haines
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Science 308:419-21. 2005
    ..45 and 5.57. This common variant likely explains approximately 43% of AMD in older adults...
  9. ncbi Estimating the relative risk in cohort studies and clinical trials of common outcomes
    Louise Anne McNutt
    Department of Epidemiology, School of Public Health, University at Albany, State University of New York, Rensselaer, NY 12144, USA
    Am J Epidemiol 157:940-3. 2003
    Logistic regression yields an adjusted odds ratio that approximates the adjusted relative risk when disease incidence is rare (<10%), while adjusting for potential confounders...
  10. ncbi Explaining heterogeneity in meta-analysis: a comparison of methods
    S G Thompson
    Department of Medical Statistics and Evaluation, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, U K
    Stat Med 18:2693-708. 1999
    ..The main example is from a meta-analysis of randomized trials of serum cholesterol reduction, in which the log-odds ratio for coronary events is related to the average extent of cholesterol reduction achieved in each trial...
  11. ncbi Diabetes mellitus as a predictor of cancer mortality in a large cohort of US adults
    Steven S Coughlin
    Epidemiology and Applied Research Branch, Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Am J Epidemiol 159:1160-7. 2004
    ..11, 1.45). These associations were not explained by high body mass. Our findings suggest that diabetes is an independent predictor of mortality from cancer of the colon, pancreas, female breast, and, in men, of the liver and bladder...
  12. ncbi The metabolic syndrome and chronic kidney disease in U.S. adults
    Jing Chen
    Tulane University Schools of Medicine and Public Health and Tropical Medicine, New Orleans, Louisiana 70112, USA
    Ann Intern Med 140:167-74. 2004
    ..The metabolic syndrome is a common risk factor for cardiovascular disease...
  13. ncbi Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33
    Richard S Houlston
    Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK
    Nat Genet 42:973-7. 2010
    ..We identified associations at four new CRC risk loci: 1q41 (rs6691170, odds ratio (OR) = 1.06, P = 9.55 × 10⁻¹⁰ and rs6687758, OR = 1.09, P = 2.27 × 10⁻⁹, 3q26.2 (rs10936599, OR = 0...
  14. ncbi A simple method for converting an odds ratio to effect size for use in meta-analysis
    S Chinn
    Department of Public Health Sciences, King s College, London, 5th Floor, Capital House, 42 Weston Street, London SE1 3QD, UK
    Stat Med 19:3127-31. 2000
    ..It is shown that a ln(odds ratio) can be converted to effect size by dividing by 1.81...
  15. pmc A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma
    Maria Teresa Landi
    Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Hum Genet 85:679-91. 2009
    ..In analyses by histology, rs2736100 (TERT), on chromosome 5p15.33, was associated with risk of adenocarcinoma (odds ratio [OR]=1.23, 95% confidence interval [CI]=1.13-1.33, p=3.02x10(-7)), but not with other histologic types (OR=1...
  16. pmc Genome-wide association study identifies novel breast cancer susceptibility loci
    Douglas F Easton
    CR UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
    Nature 447:1087-93. 2007
    ..05 level compared with an estimated 1,343 that would be expected by chance, indicating that many additional common susceptibility alleles may be identifiable by this approach...
  17. pmc Social capital and self-rated health: a contextual analysis
    I Kawachi
    Department of Health and Social Behavior, Harvard School of Public Health, Boston, Mass 02115, USA
    Am J Public Health 89:1187-93. 1999
    ..This article reports a contextual analysis of social capital and individual self-rated health, with adjustment for individual household income, health behaviors, and other covariates...
  18. ncbi Identifying risk for obesity in early childhood
    Philip R Nader
    Division of Community Pediatrics, University of California, San Diego, California, USA
    Pediatrics 118:e594-601. 2006
    ..Our aim with this study was to assist clinicians by estimating the predictive value of earlier levels of BMI status on later risk of overweight and obesity during the middle childhood and early adolescent years...
  19. pmc Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior
    Thorgeir E Thorgeirsson
    1 deCODE genetics, Reykjavik, Iceland 2 Center for Biomolecular Science and Engineering, Jack Baskin School of Engineering, University of California, Santa Cruz, California, USA
    Nat Genet 42:448-53. 2010
    ..Nominal associations with lung cancer were observed at both 8p11 (rs6474412[T], odds ratio (OR) = 1.09, P = 0.04) and 19q13 (rs4105144[C], OR = 1.12, P = 0.0006).
  20. ncbi Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study
    Olivia Fletcher
    Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    J Natl Cancer Inst 103:425-35. 2011
    ..Genome-wide association studies have identified several common genetic variants associated with breast cancer risk. It is likely, however, that a substantial proportion of such loci have not yet been discovered...
  21. pmc Genome-wide association study of blood pressure and hypertension
    Daniel Levy
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Nat Genet 41:677-87. 2009
    ..Identifying genes associated with blood pressure advances our understanding of blood pressure regulation and highlights potential drug targets for the prevention or treatment of hypertension...
  22. ncbi Maternal obesity and pregnancy outcome: a study of 287,213 pregnancies in London
    N J Sebire
    Department of Obstetrics and Gynaecology, Imperial College School of Medicine at St Mary's Hospital, London, UK
    Int J Obes Relat Metab Disord 25:1175-82. 2001
    ..to women with normal BMI, the following outcomes were significantly more common in obese pregnant women (odds ratio (99% confidence interval) for BMI 25--30 and BMI> or =30 respectively): gestational diabetes mellitus (1.68 (1...
  23. pmc A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration
    Gregory S Hageman
    Department of Ophthalmology and Visual Sciences, Cell Biology and Functional Genomics Laboratory, University of Iowa, Iowa City, IA 52240, USA
    Proc Natl Acad Sci U S A 102:7227-32. 2005
    ..One common at-risk haplotype is present at a frequency of 50% in AMD cases and 29% in controls [odds ratio (OR) = 2.46, 95% confidence interval (1.95-3.11)]...
  24. pmc Interactions between genetic variants and breast cancer risk factors in the breast and prostate cancer cohort consortium
    Daniele Campa
    Genomic Epidemiology Group, German Cancer Research Center Deutsches Krebsforschungszentrum DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Natl Cancer Inst 103:1252-63. 2011
    ..Relatively little is known about the possible interactions between these loci and the established risk factors for breast cancer...
  25. ncbi The prevalence and etiology of elevated aminotransferase levels in the United States
    Jeanne M Clark
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Gastroenterol 98:960-7. 2003
    ..Unexplained aminotransferase elevation was strongly associated with adiposity and other features of the metabolic syndrome, and thus may represent nonalcoholic fatty liver disease...
  26. ncbi Maternal morbid obesity and the risk of adverse pregnancy outcome
    Marie I Cedergren
    Division of Obstetrics and Gynecology, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping University, SE 581 85 Linkoping, Sweden
    Obstet Gynecol 103:219-24. 2004
    ..To evaluate whether morbidly obese women have an increased risk of pregnancy complications and adverse perinatal outcomes...
  27. pmc Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies
    R Huxley
    The George Institute for International Health, The University of Sydney, PO Box M201, Missenden Road, Sydney NSW 2050, Australia
    Br J Cancer 92:2076-83. 2005
    ..The age and sex-adjusted odds ratio (OR) for pancreatic cancer associated with type-II diabetes was obtained from each study...
  28. pmc Comparing exposure assessment methods for traffic-related air pollution in an adverse pregnancy outcome study
    Jun Wu
    Program in Public Health and Department of Epidemiology, Anteater Instruction and Research Office, University of California, Irvine, CA 92697 3957, USA
    Environ Res 111:685-92. 2011
    ..Yet, little information exists on how effect estimates are impacted by the different exposure assessment methods employed in these studies...
  29. pmc The association between glucometabolic disturbances, traditional cardiovascular risk factors and self-rated health by age and gender: a cross-sectional analysis within the Malmö Preventive Project
    Margret Leosdottir
    Department of Cardiology, Skane University Hospital, and Heart Health Group Department of Clinical Sciences, Lund University, Malmo, Sweden
    Cardiovasc Diabetol 10:118. 2011
    ..Whether this age-related reduction applies to CVD risk factors, and whether it is limited to established diabetes mellitus (DM) or also applies to pre-diabetic conditions are not well known...
  30. ncbi Much ado about nothing: a comparison of the performance of meta-analytical methods with rare events
    Michael J Bradburn
    Centre for Statistics in Medicine, Wolfson College, Linton Road, Oxford OX2 6UD, UK
    Stat Med 26:53-77. 2007
    ..The bias was greatest in inverse variance and DerSimonian and Laird odds ratio and risk difference methods, and the Mantel-Haenszel (MH) odds ratio method using a 0.5 zero-cell correction...
  31. ncbi Reported methodologic quality and discrepancies between large and small randomized trials in meta-analyses
    L L Kjaergard
    Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Center for Clinical Intervention Research, Copenhagen University Hospital, H S Rigshospitalet, DK 2100 Copenhagen, Denmark
    Ann Intern Med 135:982-9. 2001
    ..To explore whether reported methodologic quality affects estimated intervention effects in randomized trials and contributes to discrepancies between the results of large randomized trials and small randomized trials in meta-analyses...
  32. ncbi Risk factors for depression among elderly community subjects: a systematic review and meta-analysis
    Martin G Cole
    Department of Psychiatry, St Mary s Hospital and McGill University, Quebeck, Canada
    Am J Psychiatry 160:1147-56. 2003
    ..The goal of this study was to determine risk factors for depression among elderly community subjects...
  33. ncbi Sedentary behavior, physical activity, and the metabolic syndrome among U.S. adults
    Earl S Ford
    Division of Adult and Community Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Obes Res 13:608-14. 2005
    ..We examined the associations among physical activity, sedentary behavior, and metabolic syndrome in a representative sample of U.S. adults...
  34. ncbi DNA repair polymorphisms and cancer risk in non-smokers in a cohort study
    G Matullo
    ISI Foundation and Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy
    Carcinogenesis 27:997-1007. 2006
    ..Further investigations of the combined effects of polymorphisms within these DNA repair genes, smoking and other risk factors may help to clarify the influence of genetic variation in the carcinogenic process...
  35. ncbi Genetic polymorphisms in the base excision repair pathway and cancer risk: a HuGE review
    Rayjean J Hung
    Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France
    Am J Epidemiol 162:925-42. 2005
    ..They found increased lung cancer risk among subjects carrying the OGG1 Cys/Cys genotype (odds ratio (OR) = 1.24, 95% confidence interval (CI): 1.01, 1...
  36. ncbi Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations
    Daiki Miki
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Nat Genet 42:893-6. 2010
    ..91 × 10⁻¹¹), odds ratio (OR) = 1.27) and TP63 (rs10937405, combined P = 7.26 × 10⁻¹²), OR = 1.31)...
  37. ncbi Complement C3 variant and the risk of age-related macular degeneration
    John R W Yates
    Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    N Engl J Med 357:553-61. 2007
    ..Age-related macular degeneration is the most common cause of blindness in Western populations. Susceptibility is influenced by age and by genetic and environmental factors. Complement activation is implicated in the pathogenesis...
  38. ncbi X-ray repair cross-complementing group 1 (XRCC1) genetic polymorphisms and gastric cancer risk: A HuGE review and meta-analysis
    HuiPing Xue
    Department of Gastroenterology, Renji Hospital, Shanghai Institute of Gastrointestinal Diseases, School of Medicine, Shanghai Jiaotong University, People s Republic of China
    Am J Epidemiol 173:363-75. 2011
    ..After stratification of the Arg399Gln SNP data by anatomic type (cardia vs. noncardia), the pooled odds ratio was 1.07 (95% CI: 0.84, 1.37; P = 0.568)...
  39. pmc Ankle brachial index combined with Framingham Risk Score to predict cardiovascular events and mortality: a meta-analysis
    F G R Fowkes
    JAMA 300:197-208. 2008
    ..Prediction models to identify healthy individuals at high risk of cardiovascular disease have limited accuracy. A low ankle brachial index (ABI) is an indicator of atherosclerosis and has the potential to improve prediction...
  40. ncbi Prevalence of kidney damage in Australian adults: The AusDiab kidney study
    Steven J Chadban
    Department of Nephrology, Monash Medical Centre, USA
    J Am Soc Nephrol 14:S131-8. 2003
    ..Identifying and targeting this section of the population may provide a means to reduce the burden of ESRD...
  41. ncbi Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma
    J Lagergren
    Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden
    N Engl J Med 340:825-31. 1999
    ..The causes of adenocarcinomas of the esophagus and gastric cardia are poorly understood. We conducted an epidemiologic investigation of the possible association between gastroesophageal reflux and these tumors...
  42. pmc Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan, United States of America
    PLoS Genet 4:e1000054. 2008
    ..Understanding the etiologic heterogeneity of breast cancer may ultimately result in improvements in prevention, early detection, and treatment...
  43. ncbi Tracking of obesity and physical activity from childhood to adulthood: the Physical Activity Longitudinal Study
    Katya M Herman
    School of Kinesiology and Health Studies, Queen s University, Kingston, Ontario
    Int J Pediatr Obes 4:281-8. 2009
    ..Tracking studies have often had limited follow-up lengths. The aim was to investigate BMI and PA tracking over 22 years from youth to adulthood...
  44. ncbi Association of the microRNA-499 variants with susceptibility to hepatocellular carcinoma in a Chinese population
    Yu Xiang
    Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing, People s Republic of China
    Mol Biol Rep 39:7019-23. 2012
    ..Compared with miRNA-499 T/T, the odds ratio (OR) of patients with miRNA-499 C/C for developing HCC was 3.630 (95% CI: 1.545-8...
  45. pmc Measures and models for causal inference in cross-sectional studies: arguments for the appropriateness of the prevalence odds ratio and related logistic regression
    Michael E Reichenheim
    Department of Epidemiology, Institute of Social Medicine, Rio de Janeiro State University, Brazil
    BMC Med Res Methodol 10:66. 2010
    ..Although some have favored the Prevalence Ratio over the Prevalence Odds Ratio -- thus suggesting the use of log-binomial or robust Poisson instead of the logistic regression models -- this ..
  46. ncbi Circulating adipocyte-fatty acid binding protein levels predict the development of the metabolic syndrome: a 5-year prospective study
    Aimin Xu
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Rd, Hong Kong, China
    Circulation 115:1537-43. 2007
    ..In the present study, we further evaluated the prospective association of A-FABP with the metabolic syndrome (MetS) as defined by the updated National Cholesterol Education Program criteria...
  47. ncbi Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: third National Health and Nutrition Examination Survey, 1988-1994
    Shanna Nesby-O'Dell
    Division of Nutrition and Physical Activity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta 30341 3717, USA
    Am J Clin Nutr 76:187-92. 2002
    ..African American women are at higher risk of vitamin D deficiency than are white women, but few studies have examined determinants of hypovitaminosis D in this population...
  48. ncbi Odds ratio based multifactor-dimensionality reduction method for detecting gene-gene interactions
    Yujin Chung
    Department of Statistics, Seoul National University San 56 1 Shillim Dong, Kwanak gu, Seoul 151 747, Korea
    Bioinformatics 23:71-6. 2007
    ..Hence, we propose the odds ratio based multifactor dimensionality reduction (OR MDR) method that uses the odds ratio as a new quantitative ..
  49. ncbi Nut consumption is associated with decreased health risk factors for cardiovascular disease and metabolic syndrome in U.S. adults: NHANES 1999-2004
    Carol E O'Neil
    Louisiana State University Agricultural Center, Baton Rouge, Louisiana 70803, USA
    J Am Coll Nutr 30:502-10. 2011
    ..Few recent epidemiologic studies have assessed the effect that nut consumption (including tree nuts and peanuts) has on health risks, including metabolic syndrome (MetS)...
  50. ncbi Vitamin D receptor genotype and breast cancer in Latinas (United States)
    S A Ingles
    Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles 90033, USA
    Cancer Causes Control 11:25-30. 2000
    ..The purpose of this study was to determine whether polymorphism in the VDR gene may also influence breast cancer risk...
  51. ncbi C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease
    John Danesh
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, United Kingdom
    N Engl J Med 350:1387-97. 2004
    ..We report data from a large study of C-reactive protein and other circulating inflammatory markers, as well as updated meta-analyses, to evaluate their relevance to the prediction of coronary heart disease...
  52. ncbi Longitudinal measurement of clinical mammographic breast density to improve estimation of breast cancer risk
    Karla Kerlikowske
    Department of Epidemiology and Biostatistics, Department of Veterans Affairs, University of California, San Francisco, CA, USA
    J Natl Cancer Inst 99:386-95. 2007
    ..Whether a change over time in clinically measured mammographic breast density influences breast cancer risk is unknown...
  53. ncbi XRCC1 gene polymorphisms and lung cancer susceptibility: a meta-analysis of 44 case-control studies
    Liping Dai
    Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Science Avenue, Zhengzhou 450001, China
    Mol Biol Rep 39:9535-47. 2012
    ..To further evaluate effect of XRCC1 polymorphisms, gene-gene interaction and gene-environment interaction on lung cancer risk, a single large sample size study with thousands of subjects is required to get conclusive results...
  54. ncbi Markers of DNA repair and susceptibility to cancer in humans: an epidemiologic review
    M Berwick
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Natl Cancer Inst 92:874-97. 2000
    ..The evolving ability to study polymorphisms in DNA repair genes may contribute to new understandings about the mechanisms of DNA repair and the way in which DNA repair capacity affects the development of cancer...
  55. ncbi Maternal effects for preterm birth: a genetic epidemiologic study of 630,000 families
    Anna C Svensson
    Division of Public Health Epidemiology, Department of Public Health Sciences, Karolinska Institutet, Norrbacka, Fifth Floor, SE 171 76 Stockholm, Sweden
    Am J Epidemiol 170:1365-72. 2009
    ..The increased odds ratio between offspring of sisters was independent of maternal risk factors for preterm birth, suggesting that the ..
  56. pmc Calcium plus vitamin D supplementation and the risk of breast cancer
    Rowan T Chlebowski
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    J Natl Cancer Inst 100:1581-91. 2008
    ..Although some observational studies have associated higher calcium intake and especially higher vitamin D intake and 25-hydroxyvitamin D levels with lower breast cancer risk, no randomized trial has evaluated these relationships...
  57. pmc Increased risk of diabetes and polychlorinated biphenyls and dioxins: a 24-year follow-up study of the Yucheng cohort
    Shu Li Wang
    Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Miaoli, Taiwan
    Diabetes Care 31:1574-9. 2008
    ..We aimed to examine the association between previous high exposures to PCBs and PCDFs and the cumulative incidence of type 2 diabetes and hypertension...
  58. ncbi The US Department of Agriculture Automated Multiple-Pass Method reduces bias in the collection of energy intakes
    Alanna J Moshfegh
    Beltsville Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, Beltsville, MD, USA
    Am J Clin Nutr 88:324-32. 2008
    ..Because the data have important program and policy applications, it is essential that the validity of the method be tested...
  59. pmc Insulin, insulin-like growth factor-I, and risk of breast cancer in postmenopausal women
    Marc J Gunter
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, New York, NY 10461, USA
    J Natl Cancer Inst 101:48-60. 2009
    ..However, no prospective studies have directly assessed associations between circulating levels of insulin and/or insulin-like growth factor (IGF)-I, a related hormone, and the risk of breast cancer independent of estrogen level...
  60. pmc Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus
    Timothy R D J Radstake
    Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Nat Genet 42:426-9. 2010
    ..39 x 10(-9) in the combined analysis). Additionally, we confirm and firmly establish the role of the MHC (P = 2.31 x 10(-18)), IRF5 (P = 1.86 x 10(-13)) and STAT4 (P = 3.37 x 10(-9)) gene regions as SSc genetic risk factors...
  61. ncbi Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia
    Elli Papaemmanuil
    Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK
    Nat Genet 41:1006-10. 2009
    ..We identified risk loci for ALL at 7p12.2 (IKZF1, rs4132601, odds ratio (OR) = 1.69, P = 1.20 x 10(-19)), 10q21.2 (ARID5B, rs7089424, OR = 1.65, P = 6.69 x 10(-19)) and 14q11...
  62. ncbi Complementary and alternative medicine use in Australia: a national population-based survey
    Charlie C L Xue
    World Health Organization Collaborating Centre for Traditional Medicine, School of Health Sciences, Melbourne, Melbourne, Australia
    J Altern Complement Med 13:643-50. 2007
    ....
  63. ncbi Assessing the probability that a positive report is false: an approach for molecular epidemiology studies
    Sholom Wacholder
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7244, USA
    J Natl Cancer Inst 96:434-42. 2004
    ..An FPRP-based criterion for deciding whether to call a finding noteworthy formalizes the process already used informally by investigators--that is, tempering enthusiasm for remarkable study findings with considerations of plausibility...
  64. ncbi Associations of hip and thigh circumferences independent of waist circumference with the incidence of type 2 diabetes: the Hoorn Study
    Marieke B Snijder
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, Netherlands
    Am J Clin Nutr 77:1192-7. 2003
    ..However, smaller hip or thigh circumference may also explain the predictive value of the WHR or WTR for type 2 diabetes...
  65. ncbi Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: a meta-analysis of randomised controlled trials
    Kausik K Ray
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Lancet 373:1765-72. 2009
    ..We undertook a meta-analysis of randomised controlled trials to determine whether intensive treatment is beneficial...
  66. ncbi Has-miR-146a polymorphism (rs2910164) and cancer risk: a meta-analysis of 19 case-control studies
    Jun Wang
    Department of Oncology, General Hospital, Jinan Command of the People s Liberation Army, Shifan Street 25, Tianqiao District, Jinan, 250031, China
    Mol Biol Rep 39:4571-9. 2012
    ..However, further well-designed studies with large sample size will be necessary to validate the risk identified in the current meta-analysis...
  67. ncbi Maternal gestational diabetes, birth weight, and adolescent obesity
    Matthew W Gillman
    Department of Ambulatory Care and Prevention, Harvard Medical School Harvard Pilgrim Health Care, Boston, Massachusetts, USA
    Pediatrics 111:e221-6. 2003
    ....
  68. ncbi Random effects meta-analysis of event outcome in the framework of the generalized linear mixed model with applications in sparse data
    Theo Stijnen
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, P O Box 9600, The Netherlands
    Stat Med 29:3046-67. 2010
    ..For instance, in the case of odds ratio meta-analysis, one can use the non-central hypergeometric distribution likelihood leading to mixed-effects ..
  69. pmc Associations between hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma
    Hwai I Yang
    Genomics Research Center, Academia Sinica and Graduate Institute of Epidemiology, National Taiwan University, Taipei, Taiwan
    J Natl Cancer Inst 100:1134-43. 2008
    ..We examined the HCC risk associated with HBV genotypes and common variants in the precore and basal core promoter (BCP) regions...
  70. ncbi Trends in socioeconomic inequalities in self-assessed health in 10 European countries
    Anton E Kunst
    Department of Public Health, Erasmus MC, 3000 DR Rotterdam, The Netherlands
    Int J Epidemiol 34:295-305. 2005
    ....
  71. ncbi Polymorphisms in XRCC1 and glutathione S-transferase genes and hepatitis B-related hepatocellular carcinoma
    Ming Whei Yu
    Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
    J Natl Cancer Inst 95:1485-8. 2003
    ..with the GSTT1-null/GSTM1-present genotype, the risk of HCC was greater for those with the Gln/Gln genotype (odds ratio = 8.07, 95% confidence interval = 1.67 to 38.93) than for those with the Arg/Arg genotype...
  72. ncbi Systematic review of the association between respiratory diseases and oral health
    Amir Azarpazhooh
    Department of Community Dentistry, Faculty of Dentistry, University of Toronto, Toronto, ON, Canada
    J Periodontol 77:1465-82. 2006
    ..The purpose of this review was to investigate evidence for a possible etiological association between oral health and pneumonia or other respiratory diseases...
  73. ncbi A multilevel model framework for meta-analysis of clinical trials with binary outcomes
    R M Turner
    MRC Clinical Trials Unit, 222 Euston Road, London NW1 2DA, UK
    Stat Med 19:3417-32. 2000
    ..Having implemented these techniques, the flexibility of multilevel modelling may be exploited in facilitating extensions to standard meta-analysis methods...
  74. ncbi Race-ethnicity-specific waist circumference cutoffs for identifying cardiovascular disease risk factors
    Shankuan Zhu
    Injury Research Center and Department of Family and Community Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Clin Nutr 81:409-15. 2005
    ..However, WC cutoffs for other race-ethnicity groups remain unknown...
  75. ncbi DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder
    W Hennah
    Medical Genetics Section, University of Edinburgh, Edinburgh EH4 2XU, Scotland
    Mol Psychiatry 14:865-73. 2009
    ..00020; corrected P=0.016; odds ratio=2.73+/-95% confidence interval (CI) 1.42-5.27) and at rs821577 in the London cohort (uncorrected P=0...
  76. ncbi The use of fractional polynomials to model continuous risk variables in epidemiology
    P Royston
    Department of Medical Statistics and Evaluation, Imperial College School of Medicine, London, UK
    Int J Epidemiol 28:964-74. 1999
    ..The traditional method of analysing continuous or ordinal risk factors by categorization or linear models may be improved...
  77. ncbi A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci
    Jin Xin Bei
    State Key Laboratory of Oncology in Southern China, Guangzhou, China
    Nat Genet 42:599-603. 2010
    ..We identified three new susceptibility loci, TNFRSF19 on 13q12 (rs9510787, Pcombined=1.53x10(-9), odds ratio (OR)=1.20), MDS1-EVI1 on 3q26 (rs6774494, Pcombined=1.34x10(-8), OR=0...
  78. ncbi Contribution of the TP53, OGG1, CHRNA3, and HLA-DQA1 genes to the risk for lung squamous cell carcinoma
    Takashi Kohno
    Biology Division, National Cancer Center Research Institute Division of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan
    J Thorac Oncol 6:813-7. 2011
    ..Therefore, significance of these functional polymorphisms was evaluated in a population, in which polymorphisms in the GWAS genes showed associations with lung SQC risk...
  79. pmc The relationship between neighborhood poverty and alcohol use: estimation by marginal structural models
    Magdalena Cerda
    Center for Urban Epidemiologic Studies, New York Academy of Medicine, New York, NY 10029, USA
    Epidemiology 21:482-9. 2010
    ....
  80. ncbi Multivariate meta-analysis
    In Sun Nam
    Queensland University of Technology, Australia
    Stat Med 22:2309-33. 2003
    ..Our preferred method is then illustrated through an analysis of a new data set on parental smoking and two health outcomes (asthma and lower respiratory disease) in children...
  81. pmc Perinatal exposure to hazardous air pollutants and autism spectrum disorders at age 8
    Amy E Kalkbrenner
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA
    Epidemiology 21:631-41. 2010
    ..Hazardous air pollutants are plausible candidate exposures for autism spectrum disorders. They have been explored in recent studies for their role in the development of these disorders...
  82. ncbi Issues in the selection of a summary statistic for meta-analysis of clinical trials with binary outcomes
    Jonathan J Deeks
    Centre for Statistics in Medicine, Institute of Health Sciences, Old Road, Headington, Oxford OX3 7LF, UK
    Stat Med 21:1575-600. 2002
    ..The appropriate selection for a particular meta-analysis may depend on understanding reasons for variation in control group event rates; in some situations uncertainty about the choice of summary statistic will remain...
  83. ncbi Maternal periodontitis as a potential risk variable for preeclampsia: a case-control study
    Fernanda Mafra Siqueira
    Department of Periodontology, Faculty of Dentistry, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
    J Periodontol 79:207-15. 2008
    ....
  84. ncbi Contribution of the NQO1 and GSTT1 polymorphisms to lung adenocarcinoma susceptibility
    Noriaki Sunaga
    Biology Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Epidemiol Biomarkers Prev 11:730-8. 2002
    ..The NQO1 and GSTT1 polymorphisms were associated with lung adenocarcinoma risk with adjusted odds ratio of 2.15 for the NQO1-Pro/Pro genotype versus the Ser/Ser genotype and adjusted odds ratio of 1...
  85. ncbi Methylenetetrahydrofolate reductase polymorphisms and breast cancer risk: a meta-analysis from 41 studies with 16,480 cases and 22,388 controls
    Xiaowei Qi
    Breast Disease Center, Southwest Hospital, Third Military Medical University, Gaotanyan Street 29, Chongqing, 400038, China
    Breast Cancer Res Treat 123:499-506. 2010
    ..It can be concluded that potentially functional MTHFR C677T polymorphism may play a low penetrance role in the development of breast cancer...
  86. ncbi NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism and the risk of eight cancers for Japanese
    Nobuyuki Hamajima
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Int J Clin Oncol 7:103-8. 2002
    ..This study was conducted to screen possible cancer sites associated with this polymorphism by a prevalent case-control design...
  87. pmc High blood pressure in obese and nonobese Japanese children: blood pressure measurement is necessary even in nonobese Japanese children
    Takako Shirasawa
    Department of Public Health, Showa University School of Medicine, Shinagawa ku, Tokyo, Japan
    J Epidemiol 20:408-12. 2010
    ..We evaluated the prevalences of HT and high-normal blood pressure (HNBP), and examined the relationship between blood pressure (BP) and body mass index (BMI), in Japanese children...
  88. ncbi Does low participation in cohort studies induce bias?
    Ellen Aagaard Nohr
    The Danish Epidemiology Science Centre, Institute of Public Health, University of Aarhus, Aarhus C, Denmark
    Epidemiology 17:413-8. 2006
    ..Participation rates in large cohort studies have decreased during the last 2 decades. The consequences of this trend for relative risk estimation are unknown...
  89. ncbi Serum B vitamin levels and risk of lung cancer
    Mattias Johansson
    International Agency for Research on Cancer, Lyon, France
    JAMA 303:2377-85. 2010
    ..B vitamins and factors related to 1-carbon metabolism help to maintain DNA integrity and regulate gene expression and may affect cancer risk...
  90. ncbi Low-density lipoprotein cholesterol and the risk of cancer: a mendelian randomization study
    Marianne Benn
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Denmark
    J Natl Cancer Inst 103:508-19. 2011
    ..Low plasma levels of low-density lipoprotein (LDL) cholesterol are associated with an increased risk of cancer, but whether this association is causal is unclear...
  91. ncbi Association of usual sleep duration with hypertension: the Sleep Heart Health Study
    Daniel J Gottlieb
    The Pulmonary Center, Boston University School of Medicine, 715 Albany Street, R 304, Boston, MA 02118 2394, USA
    Sleep 29:1009-14. 2006
    ..This study assesses the relationship between usual sleep duration and hypertension in a community-based cohort...
  92. ncbi A population-based study of juvenile disc degeneration and its association with overweight and obesity, low back pain, and diminished functional status
    Dino Samartzis
    Department of Orthopaedics and Traumatology, University of Hong Kong, Hong Kong, SAR, China
    J Bone Joint Surg Am 93:662-70. 2011
    ..Consequently, the purpose of this study was to assess the prevalence, determinants, and clinical relevance associated with juvenile disc degeneration of the lumbar spine in individuals without spinal deformities...
  93. ncbi Validation of the Gail et al. model of breast cancer risk prediction and implications for chemoprevention
    B Rockhill
    B Rockhill, C Byrne, Channing Laboratory, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    J Natl Cancer Inst 93:358-66. 2001
    ..to aid decision making regarding potential prevention options for breast cancer, including chemoprevention with tamoxifen...
  94. ncbi Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study
    B Fisher
    National Surgical Adjuvant Breast and Bowel Project, Allegheny University of the Health Sciences, Pittsburgh, PA 15212 5234, USA
    J Natl Cancer Inst 90:1371-88. 1998
    ..To test this hypothesis, the National Surgical Adjuvant Breast and Bowel Project initiated the Breast Cancer Prevention Trial (P-1) in 1992...
  95. pmc NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20852 7234, USA
    Lancet 366:649-59. 2005
    ..Associations between polymorphisms in other NAT and GST genes and bladder-cancer risk have been inconsistent...
  96. pmc Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium
    Therese Truong
    Genetic Epidemiology Group, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon Cedex 08, France
    J Natl Cancer Inst 102:959-71. 2010
    ....
  97. ncbi Serum C-peptide, insulin-like growth factor (IGF)-I, IGF-binding proteins, and colorectal cancer risk in women
    R Kaaks
    International Agency for Research on Cancer, Lyon, France
    J Natl Cancer Inst 92:1592-600. 2000
    ..To test this hypothesis, we conducted a case-control study nested within a cohort of 14 275 women in New York...
  98. ncbi ASIP and TYR pigmentation variants associate with cutaneous melanoma and basal cell carcinoma
    Daniel F Gudbjartsson
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 40:886-91. 2008
    ..known to affect a similar spectrum of pigmentation traits as MC1R variants, conferred significant risk of CM (odds ratio (OR) = 1.45, P = 1.2 x 10(-9)) and BCC (OR = 1.33, P = 1.2 x 10(-6))...
  99. ncbi Daytime and nighttime blood pressure as predictors of death and cause-specific cardiovascular events in hypertension
    Robert H Fagard
    Hypertension and Cardiovascular Rehabilitation Unit, Faculty of Medicine, University of Leuven, Belgium
    Hypertension 51:55-61. 2008
    ....
  100. ncbi Clinical risk factors, DNA variants, and the development of type 2 diabetes
    Valeriya Lyssenko
    Department of Clinical Sciences, Lund University, Malmo, Sweden
    N Engl J Med 359:2220-32. 2008
    ..Type 2 diabetes mellitus is thought to develop from an interaction between environmental and genetic factors. We examined whether clinical or genetic factors or both could predict progression to diabetes in two prospective cohorts...
  101. ncbi Polymorphisms in folate metabolic genes and lung cancer risk in Xuan Wei, China
    Min Shen
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, MSC 7240, 6120 Executive Blvd, Bethesda, MD 20892 7240, USA
    Lung Cancer 49:299-309. 2005
    ..002 and P=0.07, respectively). In summary, three genetic variants in folate metabolism genes are associated with an increased risk of lung cancer in Xuan Wei, China...

Research Grants62

  1. Immune Mechanism of Rejection in Human Lung Allografts
    Thalachallour Mohanakumar; Fiscal Year: 2013
    ..V (ColV) and K-alpha 1 Tubulin (K?1T)) and these patients demonstrate an increased risk of developing PGD (odds ratio of 3.09, (p<0.02), increased levels of pro-inflammatory cytokines (p<0...
  2. Mechanisms of Airway Smooth Muscle Hypertrophy
    Marc B Hershenson; Fiscal Year: 2013
    ..of gender, birth weight and gestational age, isolation of mesenchymal stromal cells increased the adjusted odds ratio of BPD over 31-fold...
  3. A novel allele influencing HIV infection among injection drug users
    Xiao Fang Yu; Fiscal Year: 2012
    ..are significantly more resistant to HIV-1 infection than those who are homozygous for the wild-type A3B alleles (odds ratio=3 [95% confidence interval 1.2-7.5])...
  4. Validation of a multi-gene test for lung cancer risk
    James C Willey; Fiscal Year: 2010
    ..In these studies the test had ROC AUC of better than 0.84 and odds ratio of more than 20 for identifying individuals over the age of 50 with more than 20 pack years smoking history who ..
  5. Glucocerebrosidase mutations in a mouse synucleinopathy model
    Robert L Nussbaum; Fiscal Year: 2011
    ..The odds ratio of finding a heterozygous GBA mutation in sporadic PD patients compared to controls ranges from the 13-28 ..
  6. NADPH-Oxidase and SLE Susceptibility
    Swapan K Nath; Fiscal Year: 2013
    ..e., in EA, missense rs17849502 is more strongly associated with lupus nephritis (odds ratio (OR) = 3.5), and with SLE in males (OR = 4.23), compared to SLE in general (OR = 2.5)...
  7. GB Virus C and Non-Hodgkins Lymphoma Risk and Prognosis
    Jack T Stapleton; Fiscal Year: 2013
    ..Canadian, population-based case- control study found an association between GBV-C and non-Hodgkin lymphoma (NHL;odds ratio of 2.72 [95% CI 1.22-6.69])...
  8. Interactions of Enteropathogenic E Coli with Intestinal Epithelial Cells
    Gail A Hecht; Fiscal Year: 2013
    ..In addition, active duty military personnel who experienced infectious gastroenteritis had an increased risk (odds ratio, 1.4) for the development of inflammatory bowel disease (2)...
  9. Telomere length, telomere maintenance genes and cancer risk
    LISA ALLYN BOARDMAN; Fiscal Year: 2012
    ..has been found to be associated with a six fold increased risk for head and neck cancer and increases to an odds ratio of 25 when combined with a history of tobacco use...
  10. Genetics of Nicotine Dependence
    Wade H Berrettini; Fiscal Year: 2013
    ..In this second population, a CHRNA3 SNP was strongly associated with CPD (p = 0.0000026, odds ratio 1.30, 95% CI 1.17-1.48)...
  11. Alpha-1 AD Carriers and Lung Cancer Risk
    Ping Yang; Fiscal Year: 2009
    ..are at a higher risk than non-carriers to develop lung cancer among cigarette smokers and never smokers (odds ratio of 1.8-2.3), independent of the effects of COPD...
  12. Investigation of Indoor Solid Fuel and Kerosene Use as Tuberculosis Risk Factors
    Kirk R Smith; Fiscal Year: 2013
    ..Division of the odds ratio (OR) obtained using all controls by the corresponding OR obtained using just latently infected controls will ..
  13. Skin Cancer and Arsenic Exposure
    Leslie K Dennis; Fiscal Year: 2013
    ..Our recent study of CM cases and arsenic found an adjusted odds ratio of 2.1 for the highest quartile of arsenic in toenail samples (trend p-value=0.001)...
  14. Stroke and aPL: Community-Based Clinicopathological Study
    STEVEN RICHARD LEVINE; Fiscal Year: 2012
    ..Our study is well-powered to be able to detect an odds ratio (OR) of 2 or greater for the primary endpoint of pathologically-proven ischemic stroke...
  15. Osteosarcoma Genetics Using an Animal Model
    JENNIE L ROWELL; Fiscal Year: 2011
    ..The highest incidence of canine OSA is in the American Greyhound (odds ratio of 17), but strikingly the closely related Spanish Greyhound (or Galgo) does not have increased risk...
  16. Copy Number Variants (CNVs) and Subclinical Atherosclerosis in MESA
    Stephen S Rich; Fiscal Year: 2010
    ..5% in the cohort) but with strong effects on disease risk (odds ratio in the 2-3 range)...
  17. MOTOR-Maternal Oral Therapy to Reduce Obstetric Risk
    STEVEN NMN OFFENBACHER; Fiscal Year: 2010
    ..g. gestational age (GA)<37 weeks: adjusted odds ratio 2.1(CI95%:1.12, 4.09)and OR=4.2 for GA<28 weeks (CI95%: 1.42,12.6)] and decreased fetal weight [e.g...
  18. Determining the Role of the Potassium Channel, KCNN3, in Atrial Fibrillation
    PATRICK THOMAS ELLINOR; Fiscal Year: 2013
    ..In a meta-analysis of the primary and replication cohorts, rs13376333 had an odds ratio of 1.52 (P=1.8x10-21)...
  19. Mesenchymal stromal cells and bronchopulmonary dysplasia
    ANTONIA PETROVA POPOVA; Fiscal Year: 2013
    ..Completion of this work will provide insight into the origins of BPD and provide training for Dr. Popova, facilitating her transition to independent investigator in patient-oriented research. ..
  20. Filaggrin Mutations and the Prognosis of Atopic Dermatitis
    David J Margolis; Fiscal Year: 2013
    ..Based on studies using the first two sequenced FLG loss-of- function variants, the odds ratio of association among those with AD as compared to those without AD was between 8 and 14...
  21. Long-Term Trends in Breast Cancer Tumor Profiles &Disparities
    Nancy Krieger; Fiscal Year: 2013
    ..position and race/ethnicity, and (2) our new study documenting that between 1992 and 2005, the US white/black odds ratio for ER+ tumors among breast cancer cases likewise rose and fell...
  22. Cancer, venous thromboembolic disease and tissue factor-bearing microparticles
    Bruce Furie; Fiscal Year: 2012
    ..to ascertain the association of thrombosis with a potential biomarker, tissue factor-bearing microparticles, the odds ratio for these microparticles in cancer patients with venous thromboembolic events compared with cancer patients ..
  23. Proinflammatory Effects Of Acute Alcohol Ingestion in Humans
    Majid Afshar; Fiscal Year: 2013
    ..is an independent risk factor for developing acute lung injury (ALI) in the first five days of hospitalization (Odds Ratio 1.40;95% Confidence Interval 1.22-1.60;p<0.0001)...
  24. Systematic functional annotation of human cis-regulatory genetic variation
    Hunter B Fraser; Fiscal Year: 2011
    ..will allow its genotyping in case/control cohorts to reveal the true population-attributable risk and odds ratio of the association, both of which are crucial to our understanding of each polymorphism's importance in ..
  25. Examination of exposure to bacterial metabolites as a risk factor for Parkinson D
    JULIE BETH contact OLSON; Fiscal Year: 2010
    ..While exposure to pesticides may be partially responsible for PD in rural areas, the odds ratio for farming itself cannot be accounted for by pesticide exposure alone...
  26. Identifying Agents which Restored BRM expression
    David N Reisman; Fiscal Year: 2013
    ..in both cancer cell lines and in primary tumors and is also strongly associated with lung cancer risk, with an odds ratio of 2.2...
  27. Fine Mapping Susceptibility Loci for Nicotine Dependence
    Ming D Li; Fiscal Year: 2013
    ..We expect that such a sample size will have sufficient power to detect 80% of true effects with an odds ratio (OR) as low as 1.3...
  28. Improving delivery of chemotherapy for older patients
    Martine Extermann; Fiscal Year: 2010
    ..the 1st group had a 37% recurrence of severe toxicity, whereas the 2nd only had a 17% recurrence rate (Odds ratio 2.85, p = 0.0075)...
  29. Glucocerebrosidase mutations in a mouse synucleinopathy model
    Robert L Nussbaum; Fiscal Year: 2010
    ..The odds ratio of finding a heterozygous GBA mutation in sporadic PD patients compared to controls ranges from the 13-28 ..
  30. IDENTIFYING RARE VARIANTS THAT INCREASE RISK FOR ALZHEIMER'S DISEASE
    Carlos Cruchaga; Fiscal Year: 2013
    ..The TREM2 R47H variant exhibits an odds ratio similar to that of the apolipoprotein e4 allele, confirming that additional rare variants with large effect ..
  31. Does Teamwork Mediate Relationship between Partner Familiarity and EMT Injuries?
    PAUL D PATTERSON; Fiscal Year: 2013
    ..AMR.net). A sample size of 500 EMTs gives over 99% power to detect an odds ratio of injury of 2.0 for a 1- standard deviation change in familiarity...
  32. Robust Test for Genetic Effect in Presence of Interaction with Age-At-First-Drink
    Tatiyana V Apanasovich; Fiscal Year: 2013
    ..needs to carefully select the functional form of the association between the factor and the logarithm of the odds ratio of alcohol dependence...
  33. Libman-Sacks Endocarditis and NPSLE
    Carlos Roldan; Fiscal Year: 2009
    ..008);and of most importance, 6) mitral valve vegetations were the strongest independent predictor of NPSLE (odds ratio 15.3, 95% Cl 1.7 - 139, p = 0.005)...
  34. EQUITY OF INPATIENT SURGERY UTILIZATION IN CALIFORNIA
    Mita Giacomini; Fiscal Year: 1992
    ..For example, the uninsured: insured odds ratio rank for each procedure will be correlated with the rank of resource intensity of the procedure...
  35. INCIDENCE OF DIABETES AND CVD IN MEXICAN AMERICANS
    Michael Stern; Fiscal Year: 2002
    ..that all-cause mortality is actually higher in Mexican Americans than in non-Hispanic whites in San Antonio (odds ratio of 1.54)...
  36. META ANALYSIS OF CLINICAL INFORMATION SERVICE TRIALS
    E Balas; Fiscal Year: 2001
    ..Binary and continuous effect (end-point) variables will be transformed and summarized in tables (odds ratio, rate difference, mean value, t value). Point and ...
  37. Prospective Study on Selenium, Genectics of Selenoenzymes, and Colorectal Cancer
    Ulrike Peters; Fiscal Year: 2013
    ..We have sufficient power (88%) to detect an odds ratio (OR) for colorectal cancer of 0...
  38. Aspirin, Helicobacter Pylori, and Peptic Ulcer Disease
    Edward Lew; Fiscal Year: 2003
    ..We will have 80% power to detect a difference of 1.56 in the odds ratio, when comparing the association of aspirin use and ulcer formation in H. pylori positive and negative subjects...
  39. Organic Solvent Mixtures & Neuropsychological Outcomes
    Ellen Kirrane; Fiscal Year: 2002
    ..2) the slope and correlation coefficient describing the association between exposure and test score; and (3) an odds ratio estimating the relative risk of an abnormal test score across exposure groups...
  40. Effects of Dioxin on Vietnamese Civilians
    David Carpenter; Fiscal Year: 2004
    ..least 163 cases of each of the three types of birth defect, and at least 489 controls will provide power to detect an elevated risk of each of these types of birth defects from dioxin exposure with an odds ratio of 1.7.
  41. Randomized trial of HIV / STD prevention in Zimbabwean youth
    Frances Cowan; Fiscal Year: 2006
    ..greatly increased risk of HIV infection when compared to young people whose parents are both alive (age adjusted odds ratio 3.43 (95% Cl: 1.93-6.11)...
  42. Finding Genes for Uterine Fibroids
    Cynthia Morton; Fiscal Year: 2007
    ..risk for UL among first-degree relatives of affected probands compared to relatives of unaffected probands; this odds ratio increases to 5...
  43. GUANYLYL CYCLASE C AS A BI0MARKER FOR COLORECTAL CANCER
    Scott Waldman; Fiscal Year: 2006
    ..The odds ratio for mortality associated with GCC RT-PCR (+) regional lymph nodes was 16.5 (95 percent CI, 1.1-756.7)...
  44. Gender as a Risk Factor for Pediatric Cardiac Surgery
    Ruey Kang Chang; Fiscal Year: 2002
    ..Logistic regression will be conducted to calculate the odds ratio for mortality comparing females with males while controlling for other patient, medical and healthcare system ..
  45. WHAT DAMAGE DOES VAGINAL BIRTH CAUSE
    John DeLancey; Fiscal Year: 2000
    ..Incontinent women have an odds ratio of 11.2 for having had a vaginal delivery compared with continent controls, twice the rate for any other factor...
  46. Proteomics of Cerebrospinal Fluid in Chronic Fatigue Syndrome
    James Baraniuk; Fiscal Year: 2009
    ..A specific pattern of proteins (biosignature) predicted CFS with a significant odds ratio of 34.5 and concordance of 80%...
  47. ANTIHYPERTENSIVE DRUG/GENE INTERACTIONS AND CV EVENTS
    Bruce Psaty; Fiscal Year: 2004
    ..58 (the difference between an odds ratio of 0.46 and 0.79 in subjects with and without the variant, respectively)...
  48. ORAL CONTRACEPTIVES AND INFLAMMATORY BOWEL DISEASE RISK
    Edward Boyko; Fiscal Year: 1992
    ..Traditional methods for matched analysis and conditional logistic regression will be used to estimate the odds ratio for ulcerative colitis among oral contraceptive users while adjusting for potential confounding factors.
  49. Statistical Strategies for Establishing Etiologic Heterogeneity of Tumors
    Colin B Begg; Fiscal Year: 2013
    ..We show that the odds ratio linking tumor sub-types of pairs of independently occurring cancers is directly related to the underlying ..
  50. Feasibility of CT in high risk breast cancer patients
    John Boone; Fiscal Year: 2003
    ..women with extremely dense breasts are at higher risk from breast cancer (by virtue of their dense breasts with odds ratio from 4 to 6), and mammography is less sensitive in these women...
  51. DIETARY SURVEY INSTRUMENT DEVELOPMENT FOR AN ETHNIC MINO
    L Su; Fiscal Year: 2001
    ..from epidemiological studies generally showed modest associations between specific nutrients and cancer, with odds ratio generally under 2.0...
  52. PROGRESSION OF AORTIC ATHEROMA IN STROKE/TIA PATIENTS
    Souvik Sen; Fiscal Year: 2004
    ..Other locations will be examined for any new change. Univariate Fisher's Exact test and Odds ratio computation and Multivariable Multiple Logistic Regression Analysis will be used to study the effect of risk ..
  53. Gene Markers: Antipsychotic-Induced Metabolic Syndrome
    GUALBERTO RUANO; Fiscal Year: 2005
    ..records, the study has been powered to detect common haplotypes of even modest individual predictive power (odds ratio of 1.7). When combined into physiotypes, the markers have specificity and sensitivity of 80% or more...
  54. RISK FOR ENAMEL FLUOROSIS AMONG NORWEGIAN CHILDREN
    David Pendrys; Fiscal Year: 2003
    ..Logistic regression analyses will be used to derive adjusted odds ratio estimates of the relative risk of enamel fluorosis associated with early fluoride exposures as well as adjusted ..
  55. CASE-CONTROL EVALUATIONS OF COLORECTAL CANCER SCREENING
    Joe Selby; Fiscal Year: 1990
    ..If related to both, we will use the strength of these associations to adjust our case-control odds ratio estimates...
  56. COMBINING DIFFERENT DATA SOURCES TO ASSESS TREATMENTS
    Christopher Schmid; Fiscal Year: 2000
    ..Analyzing 115 meta-analyses with binary outcomes, we found significant correlation with the odds ratio in 15 percent of cases...
  57. Aortic, Cardiovascular Disease and Silent Brain Infarcts
    Marco Di Tullio; Fiscal Year: 2009
    ..24-hour ambulatory blood pressure monitoring will also be performed. Odds ratio for aortic/cardiac/24-hour blood pressure abnormalities and silent brain infarcts will be calculated by logistic ..
  58. Genetic Test for Schizophrenia Susceptibility: A Targeted Approach
    Mark Brennan; Fiscal Year: 2007
    ..another involving proprietary genetic markers in conjunction with novel microdeletions elsewhere in the genome (odds ratio of approximately 15)...
  59. PSA SCREENING AND PROSTATE CANCER MORTALITY
    George Rhoads; Fiscal Year: 2002
    ..The extent of protection (measured as an odds ratio for prostate cancer death of less than 1...
  60. PERIODONTITIS AND PRETERM LOW BIRTH WEIGHT
    Steven Offenbacher; Fiscal Year: 2001
    ..e. greater than or equal to 60% of sites with 3 or more mm of attachment loss) have an adjusted odds ratio of 7.5 for having a PLBW...
  61. OCCUPATIONAL LEAD EXPOSURE: RISK TO THE AGING WORKER
    Lisa Morrow; Fiscal Year: 2002
    ..This is a revision of 1 R01 OH03891-01 ..
  62. ANALYZING CLUSTERED DATA IN PERIODONTAL RESEARCH
    Melissa Begg; Fiscal Year: 1999
    ..Methods include an extended Mantel-Haenszel test, an estimator of the standard error of the common odds ratio and a test of homogeneity across strata...