probability

Summary

Summary: The study of chance processes or the relative frequency characterizing a chance process.

Top Publications

  1. pmc The role of human orbitofrontal cortex in value comparison for incommensurable objects
    Thomas H B FitzGerald
    Wellcome Trust Centre for Neuroimaging, London WC1N 3BG, United Kingdom
    J Neurosci 29:8388-95. 2009
  2. ncbi Distributed neural representation of expected value
    Brian Knutson
    Department of Psychology, Stanford University, Stanford, California 94305, USA
    J Neurosci 25:4806-12. 2005
  3. doi Astrocytes impose postburst depression of release probability at hippocampal glutamate synapses
    My Andersson
    Institute of Neuroscience and Physiology, Gothenburg University, 405 30 Goteborg, Sweden
    J Neurosci 30:5776-80. 2010
  4. ncbi Learning the value of information in an uncertain world
    Timothy E J Behrens
    FMRIB Centre, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Nat Neurosci 10:1214-21. 2007
  5. ncbi A general empirical model of protein evolution derived from multiple protein families using a maximum-likelihood approach
    S Whelan
    Department of Zoology, University of Cambridge, Cambridge, England
    Mol Biol Evol 18:691-9. 2001
  6. ncbi A probability-based approach for high-throughput protein phosphorylation analysis and site localization
    Sean A Beausoleil
    Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, Massachusetts 02115, USA
    Nat Biotechnol 24:1285-92. 2006
  7. ncbi Discrete coding of reward probability and uncertainty by dopamine neurons
    Christopher D Fiorillo
    Institute of Physiology, University of Fribourg, CH 1700 Fribourg, Switzerland
    Science 299:1898-902. 2003
  8. pmc Elapsed decision time affects the weighting of prior probability in a perceptual decision task
    Timothy D Hanks
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, and National Primate Research Center, University of Washington, Seattle, Washington 98195 7290, USA
    J Neurosci 31:6339-52. 2011
  9. ncbi Neural systems responding to degrees of uncertainty in human decision-making
    Ming Hsu
    Division of Humanities and Social Sciences, 228 77, California Institute of Technology, Pasadena, CA 91125, USA
    Science 310:1680-3. 2005
  10. pmc Diagnosis of multiple cancer types by shrunken centroids of gene expression
    Robert Tibshirani
    Department of Health, Research and Policy, and Statistics, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 99:6567-72. 2002

Detail Information

Publications322 found, 100 shown here

  1. pmc The role of human orbitofrontal cortex in value comparison for incommensurable objects
    Thomas H B FitzGerald
    Wellcome Trust Centre for Neuroimaging, London WC1N 3BG, United Kingdom
    J Neurosci 29:8388-95. 2009
    ..These findings indicate that orbitofrontal cortex plays a pivotal role in valuation for incommensurable goods, a critical component process in human decision making...
  2. ncbi Distributed neural representation of expected value
    Brian Knutson
    Department of Psychology, Stanford University, Stanford, California 94305, USA
    J Neurosci 25:4806-12. 2005
    Anticipated reward magnitude and probability comprise dual components of expected value (EV), a cornerstone of economic and psychological theory. However, the neural mechanisms that compute EV have not been characterized...
  3. doi Astrocytes impose postburst depression of release probability at hippocampal glutamate synapses
    My Andersson
    Institute of Neuroscience and Physiology, Gothenburg University, 405 30 Goteborg, Sweden
    J Neurosci 30:5776-80. 2010
    ..We show that CA3-CA1 glutamate synapses exhibit a prominent depression of presynaptic release probability for approximately 1 s after such a burst...
  4. ncbi Learning the value of information in an uncertain world
    Timothy E J Behrens
    FMRIB Centre, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Nat Neurosci 10:1214-21. 2007
    ..Furthermore, variations in this ACC signal across the population predict variations in subject learning rates. Our results provide a formal account of how we weigh our different experiences in guiding our future actions...
  5. ncbi A general empirical model of protein evolution derived from multiple protein families using a maximum-likelihood approach
    S Whelan
    Department of Zoology, University of Cambridge, Cambridge, England
    Mol Biol Evol 18:691-9. 2001
    ....
  6. ncbi A probability-based approach for high-throughput protein phosphorylation analysis and site localization
    Sean A Beausoleil
    Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, Massachusetts 02115, USA
    Nat Biotechnol 24:1285-92. 2006
    ..data set sensitivity by efficiently distracting incorrect peptide spectral matches (PSMs), and we present a probability-based score, the Ascore, that measures the probability of correct phosphorylation site localization based on ..
  7. ncbi Discrete coding of reward probability and uncertainty by dopamine neurons
    Christopher D Fiorillo
    Institute of Physiology, University of Fribourg, CH 1700 Fribourg, Switzerland
    Science 299:1898-902. 2003
    ..It is determined by probability P, being maximal at P = 0.5 and decreasing at higher and lower probabilities...
  8. pmc Elapsed decision time affects the weighting of prior probability in a perceptual decision task
    Timothy D Hanks
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, and National Primate Research Center, University of Washington, Seattle, Washington 98195 7290, USA
    J Neurosci 31:6339-52. 2011
    ..novel theory: the brain exploits elapsed time during decision formation to combine sensory evidence with prior probability. Elapsed time is useful because (1) decisions that linger tend to arise from less reliable evidence, and (2) ..
  9. ncbi Neural systems responding to degrees of uncertainty in human decision-making
    Ming Hsu
    Division of Humanities and Social Sciences, 228 77, California Institute of Technology, Pasadena, CA 91125, USA
    Science 310:1680-3. 2005
    Much is known about how people make decisions under varying levels of probability (risk). Less is known about the neural basis of decision-making when probabilities are uncertain because of missing information (ambiguity)...
  10. pmc Diagnosis of multiple cancer types by shrunken centroids of gene expression
    Robert Tibshirani
    Department of Health, Research and Policy, and Statistics, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 99:6567-72. 2002
    ..The technique is general and can be used in many other classification problems. To demonstrate its effectiveness, we show that the method was highly efficient in finding genes for classifying small round blue cell tumors and leukemias...
  11. doi The probability of neurotransmitter release: variability and feedback control at single synapses
    Tiago Branco
    Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology and Pharmacology, University College London, WC1E 6BT, UK
    Nat Rev Neurosci 10:373-83. 2009
    ..imaging studies have demonstrated that synaptic terminals can individually set their neurotransmitter release probability dynamically through local feedback regulation...
  12. ncbi Processing of low-probability sounds by cortical neurons
    Nachum Ulanovsky
    Department of Physiology, Hebrew University, Hadassah Medical School, Box 12272, Jerusalem 91120, Israel
    Nat Neurosci 6:391-8. 2003
    ..In contrast, auditory thalamic neurons were insensitive to the probability of frequency deviants...
  13. doi Local dendritic activity sets release probability at hippocampal synapses
    Tiago Branco
    MRC Laboratory for Molecular Cell Biology and Cell Biology Unit, University College London, Gower Street, London WC1E6BT, UK
    Neuron 59:475-85. 2008
    The arrival of an action potential at a synapse triggers neurotransmitter release with a limited probability, p(r)...
  14. pmc Examining size-strength relationships at hippocampal synapses using an ultrastructural measurement of synaptic release probability
    Tiago Branco
    Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK
    J Struct Biol 172:203-10. 2010
    Release probability (p(r)) is a fundamental presynaptic parameter which is critical in defining synaptic strength...
  15. ncbi Estimating the probability of identity among genotypes in natural populations: cautions and guidelines
    L P Waits
    Department of Fish and Wildlife Resources, University of Idaho, Moscow, ID 83844 1136, USA
    Mol Ecol 10:249-56. 2001
    ..Statistical methods that estimate the probability of sampling identical genotypes using theoretical equations generally assume random associations between ..
  16. pmc The probability of fixation in populations of changing size
    S P Otto
    Department of Zoology, University of British Columbia, Vancouver, Canada
    Genetics 146:723-33. 1997
    ..In this paper, we calculate the probability of fixation of beneficial mutations that occur in populations of changing size...
  17. ncbi The finite state projection algorithm for the solution of the chemical master equation
    Brian Munsky
    Mechanical and Environmental Engineering, University of California Santa Barbara, Santa Barbara, California 93106, USA
    J Chem Phys 124:044104. 2006
    ..One can describe the chemical populations of such systems with probability density vectors that evolve according to a set of linear ordinary differential equations known as the chemical ..
  18. doi Connectivity-based parcellation of human cingulate cortex and its relation to functional specialization
    Matthias Beckmann
    Centre for Functional MRI of the Brain, University of Oxford, Oxford OX1 3UD, United Kingdom
    J Neurosci 29:1175-90. 2009
    ..Cingulate voxels with a high probability of connection with the different targets formed separate clusters within cingulate cortex...
  19. ncbi Multievent: an extension of multistate capture-recapture models to uncertain states
    Roger Pradel
    CEFE, UMR 5175, 1919 Route de Mende, F 34293 Montpellier, Cedex 05, France
    Biometrics 61:442-7. 2005
    ..I also show in this article that the memory model, in which the next state or location is influenced by the previous state occupied, can be fully treated within the framework of multievent models...
  20. pmc Constructing inverse probability weights for marginal structural models
    Stephen R Cole
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Am J Epidemiol 168:656-64. 2008
    The method of inverse probability weighting (henceforth, weighting) can be used to adjust for measured confounding and selection bias under the four assumptions of consistency, exchangeability, positivity, and no misspecification of the ..
  21. doi Serological response to human endogenous retrovirus K in melanoma patients correlates with survival probability
    Silvia Hahn
    Retroelement Section, Paul Ehrlich Institut, Langen, Germany
    AIDS Res Hum Retroviruses 24:717-23. 2008
    ..serum level of S100-beta) revealed serological HERV-K reactivity as an independent marker of reduced survival probability (p = 0.027) in melanoma patients with the early stages of the disease (AJCC I-III)...
  22. ncbi Neural correlates of decision variables in parietal cortex
    M L Platt
    Center for Neural Science, New York University, New York 10003, USA
    Nature 400:233-8. 1999
    ..This assessment can be computed, in part, from the probability that each action will result in a gain and the magnitude of the gain expected...
  23. pmc Dissociable prior influences of signal probability and relevance on visual contrast sensitivity
    Valentin Wyart
    Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, United Kingdom
    Proc Natl Acad Sci U S A 109:3593-8. 2012
    ..Here, we reassessed the prior influences of signal probability and relevance on visual contrast detection using a reverse-correlation technique that quantifies how signal-..
  24. ncbi A representation of the hazard rate of elapsed time in macaque area LIP
    Peter Janssen
    Howard Hughes Medical Institute, National Primate Research Center and Department of Physiology and Biophysics, University of Washington, Box 357290, Seattle, Washington 98195, USA
    Nat Neurosci 8:234-41. 2005
    ..Such anticipation requires knowledge of elapsed time and of the probability that an event will occur...
  25. pmc Overlapping dual ERP responses to low cloze probability sentence continuations
    Katherine A DeLong
    Department of Cognitive Science, University of California, San Diego, La Jolla, California 92093 0515, USA
    Psychophysiology 48:1203-7. 2011
    ..We suggest that this positivity is consistent with hypotheses that additional neural processing may be invoked when highly expected continuations are not encountered in the input and speculate briefly on possible functional correlates...
  26. ncbi Dissociable roles of ventral and dorsal striatum in instrumental conditioning
    John O'Doherty
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London WC1N 3BG, UK
    Science 304:452-4. 2004
    ..Our results suggest partly dissociable contributions of the ventral and dorsal striatum, with the former corresponding to the critic and the latter corresponding to the actor...
  27. ncbi A method for estimating the probability of adverse drug reactions
    C A Naranjo
    Clin Pharmacol Ther 30:239-45. 1981
  28. doi Review of inverse probability weighting for dealing with missing data
    Shaun R Seaman
    MRC Biostatistics Unit, Institute of Public Health, Forvie Site, Robinson Way, Cambridge, UK
    Stat Methods Med Res 22:278-95. 2013
    ..e. individuals with no missing values. This can induce bias, however. Inverse probability weighting (IPW) is a commonly used method to correct this bias...
  29. pmc Per-contact probability of HIV transmission in homosexual men in Sydney in the era of HAART
    Fengyi Jin
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Darlinghurst, Australia
    AIDS 24:907-13. 2010
    The objective of this study is to estimate per-contact probability of HIV transmission in homosexual men due to unprotected anal intercourse (UAI) in the era of HAART.
  30. ncbi RNA secondary structure prediction using stochastic context-free grammars and evolutionary history
    B Knudsen
    Department of Genetics and Ecology, The Institute of Biological Sciences, University of Aarhus, Building 550, Ny Munkegade, 8000 Aarhus C, Denmark
    Bioinformatics 15:446-54. 1999
    ..The method reported here is based on stochastic context-free grammars (SCFGs) to give a prior probability distribution of structures.
  31. ncbi A globally coherent fingerprint of climate change impacts across natural systems
    Camille Parmesan
    Integrative Biology, Patterson Laboratories 141, University of Texas, Austin, Texas 78712, USA
    Nature 421:37-42. 2003
    ..This suite of analyses generates 'very high confidence' (as laid down by the IPCC) that climate change is already affecting living systems...
  32. pmc Modeling the probability distribution of positional errors incurred by residential address geocoding
    Dale L Zimmerman
    Department of Statistics and Actuarial Science and Center for Health Policy and Research, University of Iowa, Iowa City, IA 52242, USA
    Int J Health Geogr 6:1. 2007
    ..Unfortunately, this process results in positional errors. Our study sought to model the probability distribution of positional errors associated with automated geocoding and E911 geocoding.
  33. ncbi Probability of HIV-1 transmission per coital act in monogamous, heterosexual, HIV-1-discordant couples in Rakai, Uganda
    R H Gray
    Departments of Population and Family Health Sciences, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Lancet 357:1149-53. 2001
    The probability of HIV-1 transmission per coital act in representative African populations is unknown. We aimed to calculate this probability overall, and to estimate how it is affected by various factors thought to influence infectivity.
  34. doi Neural response to reward anticipation under risk is nonlinear in probabilities
    Ming Hsu
    Beckman Institute for Advanced Science and TechnologyUniversity of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Neurosci 29:2231-7. 2009
    ..Models such as prospect theory have relaxed this assumption and introduced the notion of a "probability weighting function," which captures the key properties found in experimental data...
  35. ncbi Probabilistic reasoning by neurons
    Tianming Yang
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, National Primate Research Center, University of Washington, Box 357290, Seattle, Washington 98195 7290, USA
    Nature 447:1075-80. 2007
    ..to choose between a pair of coloured targets after viewing four shapes, shown sequentially, that governed the probability that one of the targets would furnish reward...
  36. doi Assigning stereochemistry to single diastereoisomers by GIAO NMR calculation: the DP4 probability
    Steven G Smith
    Unilever Centre for Molecular Science Informatics, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    J Am Chem Soc 132:12946-59. 2010
    ..We have compared several approaches for assigning a probability to each candidate structure and have tested the ability of these methods to distinguish up to 64 possible ..
  37. doi Surface-enhanced Raman spectroscopy of benzenethiol adsorbed from the gas phase onto silver film over nanosphere surfaces: determination of the sticking probability and detection limit time
    Kevin B Biggs
    Northwestern University, Department of Chemistry, Evanston, Illinois 60208 3113, USA
    J Phys Chem A 113:4581-6. 2009
    ..The DLt for this kinetically controlled sensor is fundamentally determined by the low sticking probability of BT on AgFONs which is determined to be approximately 2 x 10(-5) at 356 K...
  38. pmc Balance of calcineurin Aα and CDK5 activities sets release probability at nerve terminals
    Sung Hyun Kim
    Department of Biochemistry, Weill Cornell Medical College, New York, New York 10065, USA
    J Neurosci 33:8937-50. 2013
    ..Thus, CNAα and CDK5 enzymatic activities are key determinants of release probability.
  39. doi Estimation of the detection probability for Yangtze finless porpoises (Neophocaena phocaenoides asiaeorientalis) with a passive acoustic method
    T Akamatsu
    NRIFE, Fisheries Research Agency, Hasaki, Kamisu, Ibaraki 314 0408, Japan
    J Acoust Soc Am 123:4403-11. 2008
    ..The calculated detection probability using acoustic method was approximately twice that for visual detection for each vessel...
  40. ncbi Multilevel linear modelling for FMRI group analysis using Bayesian inference
    Mark W Woolrich
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK
    Neuroimage 21:1732-47. 2004
    ..We also demonstrate that we can infer on the top level of multilevel hierarchies by inferring on the levels of the hierarchy separately and passing summary statistics of a noncentral multivariate t distribution between them...
  41. pmc Activity-dependent coordination of presynaptic release probability and postsynaptic GluR2 abundance at single synapses
    Hirofumi Tokuoka
    Medical Research Council Laboratory for Molecular Cell Biology and Cell Biology Unit, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 105:14656-61. 2008
    The strength of an excitatory synapse depends on both the presynaptic release probability (p(r)) and the abundance of functional postsynaptic AMPA receptors...
  42. pmc Validation of probability equation and decision tree in predicting subsequent dengue hemorrhagic fever in adult dengue inpatients in Singapore
    Tun L Thein
    Communicable Disease Center, Tan Tock Seng Hospital, Singapore
    Am J Trop Med Hyg 85:942-5. 2011
    We developed a probability equation and a decision tree from 1,973 predominantly dengue serotype 1 hospitalized adult dengue patients in 2004 to predict progression to dengue hemorrhagic fever (DHF), applied in our clinic since March ..
  43. ncbi Representation of action-specific reward values in the striatum
    Kazuyuki Samejima
    Department of Computational Neurobiology, ATR Computational Neuroscience Laboratories, 619 0288 Kyoto, Japan
    Science 310:1337-40. 2005
    ..Fewer neurons were tuned to relative values or action choice. These results suggest representation of action values in the striatum, which can guide action selection in the basal ganglia circuit...
  44. ncbi Is progesterone elevation on the day of human chorionic gonadotrophin administration associated with the probability of pregnancy in in vitro fertilization? A systematic review and meta-analysis
    C A Venetis
    Unit for Human Reproduction, 1st Department of Obstetrics and Gynaecology, Papageoriou General Hospital, Aristotle University of Thessaloniki, Nea Efkarpia, Peripheral Road, Thessaloniki, Greece
    Hum Reprod Update 13:343-55. 2007
    ..progesterone elevation on the day of human chorionic gonadotrophin (hCG) administration is associated with the probability of pregnancy. Eligible studies were considered those in which patients did not participate more than once...
  45. ncbi Open capture-recapture models with heterogeneity: I. Cormack-Jolly-Seber model
    Shirley Pledger
    School of Mathematical and Computing Sciences, Victoria University of Wellington, P O Box 600, Wellington, New Zealand
    Biometrics 59:786-94. 2003
    ..Bias in parameter estimates is reduced by including individual heterogeneity. Model selection and bias reduction are important in population studies and for making informed management decisions...
  46. doi Tonic activation of GABAB receptors reduces release probability at inhibitory connections in the cerebellar glomerulus
    Lisa Mapelli
    Department of Physiological and Pharmacological Sciences and National Consortium for the Physics of Matter, University of Pavia, I 27100 Pavia, Italy
    J Neurophysiol 101:3089-99. 2009
    ..neurotransmission, revealing that tonic GABA(B) receptor activation by ambient GABA regulates release probability. Blocking GABA(B) receptors with CGP55845 enhanced the first inhibitory postsynaptic current (IPSC) and short-..
  47. pmc A statistical sampling algorithm for RNA secondary structure prediction
    Ye Ding
    Bioinformatics Center, Wadsworth Center, New York State Department of Health, 150 New Scotland Avenue, Albany, NY 12208, USA
    Nucleic Acids Res 31:7280-301. 2003
    ..Statistical sampling provides a means to estimate the probability of any structural motif, with or without constraints...
  48. ncbi Prediction error as a linear function of reward probability is coded in human nucleus accumbens
    Birgit Abler
    Department of Psychiatry, University of Ulm, Leimgrubenweg 12 14, 89075 Ulm, Germany
    Neuroimage 31:790-5. 2006
    Reward probability has been shown to be coded by dopamine neurons in monkeys...
  49. ncbi Linking retinotopic fMRI mapping and anatomical probability maps of human occipital areas V1 and V2
    A M Wohlschlager
    Institut fur Medizin, Forschungszentrum Julich, Germany
    Neuroimage 26:73-82. 2005
    ..By averaging the individual maps into group maps, probability maps of functionally defined V1 or V2 were determined and compared to anatomical probability maps of Brodmann ..
  50. doi Sexual behavior in the United States: results from a national probability sample of men and women ages 14-94
    Debby Herbenick
    Center for Sexual Health Promotion, Indiana University, Bloomington, IN, USA
    J Sex Med 7:255-65. 2010
    ..Despite a demonstrated relationship between sexual behaviors and health, including clinical risks, little is known about contemporary sexual behavior...
  51. ncbi Gene tree distributions under the coalescent process
    James H Degnan
    Department of Mathematics and Statistics, University of New Mexico, Albuquerque, New Mexico 87131, USA
    Evolution 59:24-37. 2005
    ..The method for computing gene tree distributions is implemented in the computer program COAL...
  52. doi Moral judgments recruit domain-general valuation mechanisms to integrate representations of probability and magnitude
    Amitai Shenhav
    Department of Psychology, Harvard University, 33 Kirkland Street, Cambridge, MA 02138, USA
    Neuron 67:667-77. 2010
    ..at the policy level, require the evaluation of choices involving outcomes of variable magnitude and probability. Many economic decisions involve the same problem...
  53. ncbi The probability of topological concordance of gene trees and species trees
    Noah A Rosenberg
    Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
    Theor Popul Biol 61:225-47. 2002
    ..Takahata (1989), Genetics 122, 957-966. Increasing the sample size is found to increase the probability of topological concordance, but a limit exists on how much the topological concordance probability can be ..
  54. pmc State reduction for network intervention in probabilistic Boolean networks
    Xiaoning Qian
    Department of Computer Science and Engineering, University of South Florida, Tampa, FL 33620, USA
    Bioinformatics 26:3098-104. 2010
    ..A major obstacle for its application is the large state space of the underlying Markov chain, which poses a serious computational challenge. Hence, it is critical to reduce the model complexity of PBNs for practical applications...
  55. doi Hierarchical structure and the prediction of missing links in networks
    Aaron Clauset
    Department of Computer Science, University of New Mexico, Albuquerque, New Mexico 87131, USA
    Nature 453:98-101. 2008
    ..Taken together, our results suggest that hierarchy is a central organizing principle of complex networks, capable of offering insight into many network phenomena...
  56. pmc Neural correlates of multisensory cue integration in macaque MSTd
    Yong Gu
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Neurosci 11:1201-10. 2008
    ..These findings show that perceptual cue integration occurs in nonhuman primates and identify a population of neurons that may form its neural basis...
  57. ncbi Coordinated memory replay in the visual cortex and hippocampus during sleep
    Daoyun Ji
    The Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Neurosci 10:100-7. 2007
    ..These results imply simultaneous reactivation of coherent memory traces in the cortex and hippocampus during sleep that may contribute to or reflect the result of the memory consolidation process...
  58. ncbi Cell survival fraction estimation based on the probability densities of domain and cell nucleus specific energies using improved microdosimetric kinetic models
    Tatsuhiko Sato
    Japan Atomic Energy Agency JAEA, Tokai, Iberaki 319 1195, Japan
    Radiat Res 178:341-56. 2012
    ..The probability densities of the domain and cell nucleus specific energies are the fundamental quantities for expressing ..
  59. pmc iProphet: multi-level integrative analysis of shotgun proteomic data improves peptide and protein identification rates and error estimates
    David Shteynberg
    Institute for Systems Biology, Seattle, WA, USA
    Mol Cell Proteomics 10:M111.007690. 2011
    ..rate estimates at the level of sequence identical peptide identifications, which in turn leads to more accurate probability estimates at the protein level...
  60. pmc Probability of cancer in pulmonary nodules detected on first screening CT
    Annette McWilliams
    Vancouver General Hospital, Vancouver, BC, Canada
    N Engl J Med 369:910-9. 2013
    ..We conducted a population-based prospective study to determine factors predicting the probability that lung nodules detected on the first screening low-dose CT scans are malignant or will be found to be ..
  61. ncbi Does this patient have deep vein thrombosis?
    Philip S Wells
    Department of Medicine, University of Ottawa, Ontario
    JAMA 295:199-207. 2006
    ..Missed DVT diagnosis may result in fatal pulmonary embolism. Since many patients may have DVT, a selective and efficient diagnostic process is needed...
  62. ncbi The Dallas Heart Study: a population-based probability sample for the multidisciplinary study of ethnic differences in cardiovascular health
    Ronald G Victor
    Donald W Reynolds Cardiovascular Clinical Research Center at the University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 8586, USA
    Am J Cardiol 93:1473-80. 2004
    ..The Dallas Heart Study was designed as a single-site, multiethnic, population-based probability sample to (1) produce unbiased population estimates of biologic and social variables that pinpoint ethnic ..
  63. ncbi P300 and probability: comparison of oddball and single-stimulus paradigms
    J Polich
    Department of Neuropharmacology, Scripps Research Institute TPC 10, La Jolla, CA 92037, USA
    Int J Psychophysiol 25:169-76. 1997
    ..Target stimulus probability was manipulated in the oddball task in different conditions (0.10, 0.30, 0.50, 0.70, 0.90)...
  64. pmc Similarity measures for protein ensembles
    Kresten Lindorff-Larsen
    Department of Molecular Biology, University of Copenhagen, Copenhagen Ø, Denmark
    PLoS ONE 4:e4203. 2009
    ..The methods are based on the estimation of the probability distributions underlying the ensembles and subsequent comparison of these distributions...
  65. ncbi Dose-finding in phase I clinical trials based on toxicity probability intervals
    Yuan Ji
    Department of Bioinformatics and Computational Biology, University of Texas, M D Anderson Cancer Center, Houston, TX, USA
    Clin Trials 4:235-44. 2007
    ..Most phase I clinical trials conducted at the M. D. Anderson Cancer Center use the algorithmic 3 + 3 design, despite the availability of more advanced model-based designs such as the continual reassessment method...
  66. ncbi Probability of walking in children with cerebral palsy in Europe
    Eva Beckung
    Queen Silvia Children s Hospital Sahlgrenska, University of Goteborg, Goteborg, Sweden
    Pediatrics 121:e187-92. 2008
    ....
  67. doi Effect of parent's death on child survival in rural Bangladesh: a cohort study
    Carine Ronsmans
    London School of Hygiene and Tropical Medicine, London, UK
    Lancet 375:2024-31. 2010
    ..We therefore investigated the effect of the death of the mother or father on the survival of the child up to age 10 years in rural Bangladesh...
  68. ncbi Combined use of clinical assessment and d-dimer to improve the management of patients presenting to the emergency department with suspected deep vein thrombosis (the EDITED Study)
    D R Anderson
    Department of Medicine, QEII Health Sciences Center, Dalhousie University, Halifax, Nova Scotia, Canada
    J Thromb Haemost 1:645-51. 2003
    ..evaluate the safety and effectiveness of a management strategy that combined consideration of clinical pretest probability and a d-dimer test to evaluate patients presenting to the emergency department with suspected deep vein ..
  69. doi Sexual behaviors, relationships, and perceived health among adult men in the United States: results from a national probability sample
    Michael Reece
    Center for Sexual Health Promotion, Indiana University, Bloomington, IN 47405, USA
    J Sex Med 7:291-304. 2010
    ..To provide a foundation for those who provide sexual health services and programs to men in the United States, the need for population-based data that describes men's sexual behaviors and their correlates remains...
  70. pmc Probabilistic inference in general graphical models through sampling in stochastic networks of spiking neurons
    Dejan Pecevski
    Institute for Theoretical Computer Science, Graz University of Technology, Graz, Austria
    PLoS Comput Biol 7:e1002294. 2011
    ....
  71. pmc The probability of a gene tree topology within a phylogenetic network with applications to hybridization detection
    Yun Yu
    Department of Computer Science, Rice University, Houston, Texas, United States of America
    PLoS Genet 8:e1002660. 2012
    ..Methods that account for both hybridization and deep coalescence in computing the probability of a gene tree topology currently exist for very limited cases...
  72. doi Biophysical mechanisms of multistability in resting-state cortical rhythms
    Frank Freyer
    Bernstein Focus State Dependencies of Learning and Bernstein Center for Computational Neuroscience, 10115 Berlin, Germany
    J Neurosci 31:6353-61. 2011
    ....
  73. doi Performance of 4 clinical decision rules in the diagnostic management of acute pulmonary embolism: a prospective cohort study
    Renee A Douma
    Academic Medical Center, Amsterdam, The Netherlands
    Ann Intern Med 154:709-18. 2011
    ..Several clinical decision rules (CDRs) are available to exclude acute pulmonary embolism (PE), but they have not been directly compared...
  74. pmc Consistent strategy updating in spatial and non-spatial behavioral experiments does not promote cooperation in social networks
    Jelena Grujic
    Grupo Interdisciplinar de Sistemas Complejos GISC, Departamento de Matematicas, Universidad Carlos III de Madrid, Leganes, Madrid, Spain
    PLoS ONE 7:e47718. 2012
    ..This suggests that the promotion of cooperation by population structure is not as straightforward in humans as often envisioned in theoretical models...
  75. doi A simple tool predicted probability of falling after aged care inpatient rehabilitation
    Catherine Sherrington
    The George Institute for Global Health, University of Sydney, PO Box M201, Missenden Road, Sydney NSW 2050, Australia
    J Clin Epidemiol 64:779-86. 2011
    ..To develop and internally validate a falls prediction tool for people being discharged from inpatient aged care rehabilitation...
  76. ncbi Improved detection of event-related functional MRI signals using probability functions
    G E Hagberg
    Laboratory of Functional Neuroimaging, Fondazione Santa Lucia IRCCS, Rome, Italy
    Neuroimage 14:1193-205. 2001
    ..The use of known probability distributions offers the possibility to control event timing and constrain the search space for finding optimal ..
  77. ncbi Three-month stability of delay and probability discounting measures
    Yu Ohmura
    Department of Behavioral Science, Graduate School of Letters, Hokkaido University, Sapporo, Japan
    Exp Clin Psychopharmacol 14:318-28. 2006
    Psychopharmacologists are interested in delay and probability discounting because the tendency to discount the value of future and uncertain rewards has been linked with drug dependency...
  78. doi A quantum theoretical explanation for probability judgment errors
    Jerome R Busemeyer
    Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA
    Psychol Rev 118:193-218. 2011
    A quantum probability model is introduced and used to explain human probability judgment errors including the conjunction and disjunction fallacies, averaging effects, unpacking effects, and order effects on inference...
  79. doi Dopamine D₁ receptors and nonlinear probability weighting in risky choice
    Hidehiko Takahashi
    Department of Psychiatry, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    J Neurosci 30:16567-72. 2010
    ..Although the normative theory in decision-making under risks assumes that people typically take the probability-weighted expectation over possible utilities, experimental studies of choices among risks suggest that outcome ..
  80. doi Daptomycin exposure and the probability of elevations in the creatine phosphokinase level: data from a randomized trial of patients with bacteremia and endocarditis
    Sujata M Bhavnani
    Institute for Clinical Pharmacodynamics, Ordway Research Institute, Albany, New York, USA
    Clin Infect Dis 50:1568-74. 2010
    The objective of this analysis was to evaluate the relationship between daptomycin exposure and the probability of an elevation in the creatine phosphokinase (CPK) level (hereafter, "CPK elevation") in patients with Staphylococcus aureus ..
  81. pmc Probability and predictors of transition from first use to dependence on nicotine, alcohol, cannabis, and cocaine: results of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC)
    Catalina Lopez-Quintero
    New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Drug Alcohol Depend 115:120-30. 2011
    This study aims to estimate general and racial-ethnic specific cumulative probability of developing dependence among nicotine, alcohol, cannabis or cocaine users, and to identify predictors of transition to substance dependence.
  82. doi Unsupervised statistical learning underpins computational, behavioural, and neural manifestations of musical expectation
    Marcus T Pearce
    Department of Computing, Goldsmiths, University of London, London SE14 6NW, UK
    Neuroimage 50:302-13. 2010
    ..statistical learning of sequential structure in music and uses this knowledge to estimate the conditional probability (and information content) of musical notes...
  83. pmc PicXAA: greedy probabilistic construction of maximum expected accuracy alignment of multiple sequences
    Sayed Mohammad Ebrahim Sahraeian
    Department of Electrical and Computer Engineering, Texas A and M University, College Station, TX 77843, USA
    Nucleic Acids Res 38:4917-28. 2010
    ..PicXAA source code is freely available at: http://www.ece.tamu.edu/~bjyoon/picxaa/...
  84. ncbi Dynamics of the firing probability of noisy integrate-and-fire neurons
    Nicolas Fourcaud
    Laboratoire de Physique Statistique, Ecole Normale Superieure, 75231 Paris Cedex 05, France
    Neural Comput 14:2057-110. 2002
    ..Analytical results for the modulation of firing probability in response to an oscillatory input current are obtained by expanding a Fokker-Planck equation for small ..
  85. doi Altered neural reward representations in pathological gamblers revealed by delay and probability discounting
    Stephan F Miedl
    Department of Systems Neuroscience, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Arch Gen Psychiatry 69:177-86. 2012
    ..The neural basis of excessive delay discounting and reduced risk sensitivity of pathological gamblers with a particular focus on subjective neural reward representations has not been previously examined...
  86. ncbi Excitatory cortical neurons form fine-scale functional networks
    Yumiko Yoshimura
    Systems Neurobiology Laboratories, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 433:868-73. 2005
    ....
  87. ncbi Incorporating covariates into standard line transect analyses
    Fernanda F C Marques
    Research Unit for Wildlife Population Assessment, CREEM, The Observatory, Buchanan Gardens, St Andrews, Fife KY16 9LZ, UK
    Biometrics 59:924-35. 2003
    ..Small sample size properties of estimators are examined via simulations. As an example the method is applied to eastern tropical Pacific dolphin sightings data...
  88. ncbi Optimal neural population coding of an auditory spatial cue
    Nicol S Harper
    Department of Physiology and UCL Ear Institute, University College London, London WC1E 6BT, UK
    Nature 430:682-6. 2004
    ..For humans, the optimal strategy to code ITDs from an acoustically measured distribution depends on frequency; above 400 Hz a homogeneous distribution is optimal, and below 400 Hz distinct sub-populations are optimal...
  89. pmc Statistics review 13: receiver operating characteristic curves
    Viv Bewick
    School of Computing, Mathematical and Information Sciences, University of Brighton, Brighton, UK
    Crit Care 8:508-12. 2004
    ..The sensitivity, specificity and likelihood ratio of a test are discussed. The uses of the receiver operating characteristic curve and the area under the curve are explained...
  90. pmc α2δ expression sets presynaptic calcium channel abundance and release probability
    Michael B Hoppa
    Department of Biochemistry, Weill Cornell Medical College, New York, New York 10023, USA
    Nature 486:122-5. 2012
    ..Expression of α2δ with an intact MIDAS motif leads to an 80% increase in release probability, while simultaneously protecting exocytosis from blockade by an intracellular Ca(2+) chelator...
  91. ncbi Radiation-induced liver disease after three-dimensional conformal radiotherapy for patients with hepatocellular carcinoma: dosimetric analysis and implication
    Jason Chia Hsien Cheng
    Department of Radiation Oncology, Koo Foundation Sun Yat Sen Cancer Center, No 125 Lih Der Road, Pei tou District, Taipei 112, Taiwan
    Int J Radiat Oncol Biol Phys 54:156-62. 2002
    ..liver disease (RILD) with patient-related and treatment-related dose-volume factors and to describe the probability of RILD by a normal tissue complication probability (NTCP) model for patients with hepatocellular carcinoma (..
  92. ncbi Combining probability from independent tests: the weighted Z-method is superior to Fisher's approach
    M C Whitlock
    Department of Zoology, University of British Columbia, Vancouver, BC, Canada
    J Evol Biol 18:1368-73. 2005
    ..biology for combining information across multiple tests of the same null hypothesis is Fisher's combined probability test...
  93. pmc From uncertainty to reward: BOLD characteristics differentiate signaling pathways
    Birgit Abler
    Department of Psychiatry, University of Ulm, Leimgrubenweg 12 14, 89075 Ulm, Germany
    BMC Neurosci 10:154. 2009
    ....
  94. doi Routes of extraocular extension of uveal melanoma: risk factors and influence on survival probability
    Sarah E Coupland
    Department of Pathology, School of Clinical Sciences, University of Liverpool, Liverpool, United Kingdom
    Ophthalmology 115:1778-85. 2008
    ..To correlate extraocular spread with other survival predictors and with metastatic death and determine whether there was any relationship between the size of the extraocular tumor and survival...
  95. ncbi Statistical neuroanatomy of the human inferior frontal gyrus and probabilistic atlas in a standard stereotaxic space
    Alexander Hammers
    MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK
    Hum Brain Mapp 28:34-48. 2007
    ..Applications include probabilistic determination of location in group studies, automatic labeling of new scans, and detection of anatomical abnormalities in patients...
  96. ncbi Excluding pulmonary embolism at the bedside without diagnostic imaging: management of patients with suspected pulmonary embolism presenting to the emergency department by using a simple clinical model and d-dimer
    P S Wells
    Division of Hematology, The Ottawa Hospital, Civic Campus, Suite 452, 737 Parkdale Avenue, Ottawa, Ontario K1Y 1J8, Canada
    Ann Intern Med 135:98-107. 2001
    ..We previously demonstrated that determining the pretest probability can assist with management and that the high negative predictive value of certain D -dimer assays may simplify ..
  97. doi Reproducibility of thalamic segmentation based on probabilistic tractography
    Catherine Traynor
    King s College London Institute of Psychiatry, Department of Clinical Neuroscience, England, UK
    Neuroimage 52:69-85. 2010
    ..A large degree of overlap in segmentation results from different subjects was obtained, particularly in thalamic regions classified as connecting to frontal, parietal, temporal and pre-central cortical target regions...
  98. ncbi Cytoarchitectonic analysis of the human extrastriate cortex in the region of V5/MT+: a probabilistic, stereotaxic map of area hOc5
    Aleksandar Malikovic
    C and O Vogt Institute for Brain Research, Heinrich Heine University, D 40225 Dusseldorf, Germany
    Cereb Cortex 17:562-74. 2007
    ..was to identify a cytoarchitectonic correlate of this region in 10 human postmortem brains and to provide a probability map of this area...
  99. doi A CoD-based reduction algorithm for designing stationary control policies on Boolean networks
    Noushin Ghaffari
    Department of Electrical and Computer Engineering, Texas A and M University, College Station, TX 77843, USA
    Bioinformatics 26:1556-63. 2010
    ..derive therapeutic intervention strategies, in particular, stationary control policies over time that shift the probability mass of the steady state distribution (SSD) away from states associated with undesirable phenotypes...
  100. pmc Replication strategies for rare variant complex trait association studies via next-generation sequencing
    Dajiang J Liu
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Hum Genet 87:790-801. 2010
    ..It is shown that currently attainable levels of sequencing error only minimally affect the comparison, and the advantage of sequence-based replication remains...
  101. ncbi Probability in transcriptional regulation and its implications for leukocyte differentiation and inducible gene expression
    D A Hume
    Departments of Biochemistry and Microbiology Parasitology and the Centre for Molecular and Cellular Biology, University of Queensland, Queensland, Australia
    Blood 96:2323-8. 2000
    ..transcriptional regulation at the level of individual cells is best described in terms of the regulation of the probability of transcription rather than the rate...

Research Grants77

  1. VERY LOW ENERGY CARDIOVERSION FOR ATRIAL FIBRILLATION
    Patrick Wolf; Fiscal Year: 2003
    ..A technology is proposed that utilizes multiple very low energy (less than .5J) shocks(VLES) with a low probability of first shock success but a high cumulative probability of conversion...
  2. Auditory Perception of Drug Names: Neighborhood Effects
    Bruce Lambert; Fiscal Year: 2006
    ..This prediction is embodied in Luce's Frequency-Weighted neighborhood Probability Rule (FWNPR)...
  3. Development and Validation of a Diagnostic Tool for Infant Head Injuries from Fal
    SUSAN SHEPS contact MARGULIES; Fiscal Year: 2010
    ..EAH) on the piglets'cortex to identify biomechanical tolerances associated with 10, 50 and 90 percent probability of EAH...
  4. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  5. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  6. Novel TIRF microscopy analyzing trafficking & signaling at the cell cortex
    Derek Toomre; Fiscal Year: 2009
    ..Consistent with the recovery act's goal, this funding will provide full-time summer employment for 4 undergraduate students and accelerate scientific achievement of the parent DP2 award...
  7. The Primate Corpus Luteum: Functional Regression and Cardiovascular Impacts
    Randy L Bogan; Fiscal Year: 2012
    ..from the CL is required to maintain pregnancy in women through the first 6-7 weeks of gestation with the probability of pregnancy loss during this period being inversely related to P4 levels...
  8. Pharmacogenetics of obesity and endocannabinergic modulation (POEM)
    Russell A Wilke; Fiscal Year: 2012
    ..using a quantitative trait nucleotide (QTN) approach, and all variants with greater than 80% posterior probability of effect (based upon Bayesian information criterion) will be genotyped in a second population, the Marshfield ..
  9. Development of VN/14-1 and Related Analogs for Breast Cancer Therapy
    VINCENT COLLINS OFUKA NJAR; Fiscal Year: 2013
    ..Objectives: To test this hypothesis, and to maximize the probability of achieving our ultimate goal while using resources most efficiently, we will carry out four specific aims: 1) ..
  10. Improving TB Diagnosis in Children with and without HIV in Kenya
    Rinn Song; Fiscal Year: 2013
    ..achieve these aims, we will conduct a prospective cohort study in Kenya enrolling children with a high pretest probability of having microbiologic confirmed TB...
  11. Intracellular Phase Diagram Creation Using a Micro-Differential Scanning Calorime
    GARY L SOLBREKKEN; Fiscal Year: 2010
    ..while the glassy vitrification state provides a chemically and mechanically stable structure that increases the probability of cell/tissue survival...
  12. Screening Complete TB Proteome for Protective Antigens
    Alan Greener; Fiscal Year: 2010
    ..developed a platform technology for high throughput, proteome-based identification of antigens that have a high probability of inducing protective cellular immunity when formulated and administered as a vaccine...
  13. Multivariate CART for survival with dental applications
    Martha E Nunn; Fiscal Year: 2013
    ..and third-party payers must make value judgments about the cost of suggested dental treatments against the probability of long-term success for those treatments...
  14. Dietary Risk for Colon Cancer in the Mouse
    Leonard H Augenlicht; Fiscal Year: 2013
    ..Thus, the perturbations track with probability of tumor formation...
  15. Somatic Stem Cells in Engineered Human Skin
    Steven Boyce; Fiscal Year: 2009
    ..required for grafting, make initial demonstrations of adnexal development in engineered skin, improve efficacy of CSS for treatment of burn scars, and increase the probability of saving the lives of patients with life-threatening burns.
  16. NATIONAL CHILDREN'S STUDY - CACHE COUNTY STUDY CENTER
    Edward Clark; Fiscal Year: 2012
    ..The NCS will employ a national probability sampling approach to select locations and participants for conduct of the study...
  17. Hepatocyte Nox proteins in the pathogenesis of hepatocellular carcinoma
    Jinah Choi; Fiscal Year: 2013
    ..of HCV, and increased the generation of ROS and nitrotyrosine in the nucleus which is likely to increase the probability of reactive species damaging the host nuclear DNA in carcinogenesis...
  18. MRI of Acute Vascular Injury and Hemorrhagic Transformation in Ischemic Stroke
    Robert A Knight; Fiscal Year: 2010
    ..of the MT- and/or MRCA-MRI parameters during the first several hours of ischemia and reperfusion to the probability of developing subsequent HT following tPA treatment...
  19. Molecular Determinants of DNA Sliding and Hopping by a DNA Repair Glycosylase
    MENG MENG ROWLAND; Fiscal Year: 2013
    ..target sites separated by a set number of base pairs, and then measure the effect of charge ablation on the probability that hUNG will slide between the sites...
  20. Regulation of the VDJ recombinase during genotoxic stress
    Karla K Rodgers; Fiscal Year: 2013
    ..the V(D)J recombinase is stabilized in G1, prolonging this cell cycle phase would be expected to increase the probability of aberrant recombination events...
  21. Creation of hyperactive transposons for mutagenesis in rodents
    Eric M Ostertag; Fiscal Year: 2011
    ..reporter gene-trap insertional mutations;a EGFP reporter system will be used as a polyA trap to maximize the probability of generating insertional mutations in each of the approximately 30,000 rat genes, and a promoterless tdTomato ..
  22. Proteome Bead-Display for Discovery of Tumor Antigens
    Mark Lim; Fiscal Year: 2013
    ..will initially fabricate an intermediate 500-member library including known CRC TAAs from the literature, high probability TAAs and those discovered in Phase I...
  23. Effects of nerve demyelination on auditory synaptic functions
    Jun Hee Kim; Fiscal Year: 2012
    ..I will study the timing and firing probability of the action potential (AP) during tetanic stimulation at several different frequencies, and the excitatory ..
  24. Live cell imaging of IgH and c-Myc gene loci and the role of nuclear organization
    Mark T Groudine; Fiscal Year: 2010
    ..and used to determine if the distance between the two loci prior to B cell stimulation influences the probability of their colocalization to the same transcription factory...
  25. FUNCTION OF THE RAS RELATED RAL PROTEINS
    LARRY FEIG; Fiscal Year: 2009
    ..possibility of targeting the Ral signaling cascade in genetically stable dermal fibroblasts, which have a low probability of developing drug resistance, as a novel mode of anti-cancer therapy...
  26. Ca2+ and ROS Crosstalk Signaling in Cardiac Mitochondria
    Shey Shing Sheu; Fiscal Year: 2013
    ..Both the increases in [Ca2+]m and ROS enhance the opening probability of MPT that further augments ROS generation...
  27. Epigenetic modulation of epileptogenesis.
    PEYMAN GOLSHANI; Fiscal Year: 2010
    ..2 channels after SE increases the excitability of hippocampal neurons and has been proposed to increase the probability of chronic seizures...
  28. L-carnitine Treatment for Vasopressor Dependent Septic Shock
    Alan E Jones; Fiscal Year: 2013
    ..As the trial progresses 28-day mortality data will be used to determine the probability that the dose of L-carnitine associated with the largest decrease in SOFA score would demonstrate efficacy in a ..
  29. NATIONAL CHILDREN'S STUDY SUPPORT
    Betty Wood; Fiscal Year: 2013
    ..The NCS will employ a national probability sampling approach to select locations and participants for conduct of the study...
  30. NATIONAL CHILDREN'S STUDY -CLINICAL BIOLOGICAL ANALYSIS
    VELAZQUEZ FRANCISCO; Fiscal Year: 2011
    ..The NCS will employ a national probability sampling approach to select locations and participants for conduct of the study...
  31. NATIONAL CHILDREN'S STUDY SUPPORT
    Betty Wood; Fiscal Year: 2011
    ..The NCS will employ a national probability sampling approach to select locations and participants for conduct of the study...
  32. NATIONAL CHILDREN'S STUDY SUPPORT
    Betty Wood; Fiscal Year: 2012
    ..The NCS will employ a national probability sampling approach to select locations and participants for conduct of the study...
  33. ROLE OF NITRIC OXIDE IN INTERSTITIAL CYSTITIS
    Lori A Birder; Fiscal Year: 2013
    ..place in these FIC cell types during long-term culture has given us a different perspective suggesting the probability of multiple changes along the sensory pathway...
  34. Violence Exposure, Immune Function &HIV/AIDS Risks in African American Young Ad
    FROUGH SAADATMAND; Fiscal Year: 2013
    ..g., multiple partners;failure to use condoms) that increase the probability f exposure to HIV. Chronic exposure to violence in multiple contexts (e.g...
  35. Bioconductor: an open computing resource for genomics
    Martin Morgan; Fiscal Year: 2010
    ..There is a high probability that funding this project will help to maintain and advance this important community resource...
  36. The development of a recombinant vaccine against human onchocerciasis
    Sara Lustigman; Fiscal Year: 2013
    ..a robust screening process, with the discovery of the best 2 recombinant Ov vaccine antigens with the highest probability for success at inducing protective immunity in humans...
  37. Vascular Structure and Function in Arteriovenous Fistula Maturation
    Jonathan Himmelfarb; Fiscal Year: 2012
    ..functional and structural alterations in the vasculature can be identified which will predict the probability of AV fistula maturation. To examine this hypothesis, we propose the following Specific Aims: 1...
  38. NATIONAL CHILDREN'S STUDY COORDINATING CENTER
    Elaine D Eaker; Fiscal Year: 2009
    ..The NCS will employ a national probability sampling approach to select locations and participants for conduct of the study...
  39. GB Virus C and Non-Hodgkins Lymphoma Risk and Prognosis
    Jack T Stapleton; Fiscal Year: 2013
    ..and by working with leaders in GBV-C and lymphoma epidemiology and clinical research, the study has a high probability of success...
  40. Allergic Condition Susceptibility Polymorphisms and Glioma Risk
    Judith Schwartzbaum; Fiscal Year: 2012
    The most common type of adult glioma (a primary malignant brain tumor), glioblastoma, has a five-year survival probability of only 3%...
  41. TBI epileptogenesis: pathologic hippocampal L-glut synaptic plasticity
    John T Slevin; Fiscal Year: 2011
    ..identify potential therapeutic targets, and pinpoint the therapeutic window to eliminate or reduce the probability of developing PTE...
  42. Individualized Treatment Strategies and Optimal Hematocrit Target for Complex Dia
    DENNIS JOSEPH COTTER; Fiscal Year: 2010
    ..We propose to apply causal analytical methods (inverse probability weighting models) that, unlike standard statistical methods, appropriately adjust for time-dependent ..
  43. Using a Biomarker Panel for Detecting Adolescent Depression
    John A Bilello; Fiscal Year: 2010
    ..The SBIR project will develop a cost effective, minimally invasive, rapid screening bioassay using a small volume of blood. An algorithm will be used to quantify the probability that a teen is suffering from MDD.
  44. Hypocretin and Locus Ceruleus Interactions in Zebrafish Development and Behavior
    Grigorios Oikonomou; Fiscal Year: 2012
    ..Activity in these centers is correlated with wakefulness and stimulation of either cluster increases the probability of waking in sleeping mice...
  45. Muscle viscosity as a protective mechanism for absorbing mechanical shock
    Armen Sarvazyan; Fiscal Year: 2013
    ..could help in anticipating joint diseases, such as tendonitis, bursitis and osteoarthritis and decreasing the probability of osteoporotic bone fracture...
  46. Role of Gprotein and SNAP-25 in NMDA vs mGluR presynaptic long-term plasticity
    KATISHA ROSE GOPAUL; Fiscal Year: 2013
    ..Presynaptic components of NMDAR-LTD and LTP alter probability of neurotransmitter release, an effect believed to be associated with release of a retrograde signal from the ..
  47. Targeting of alpha7 nAChR for therapeutic effects
    Roger L Papke; Fiscal Year: 2013
    ..to measure the desensitizing properties of specific ligands and to overcome the intrinsically limited open probability of a7 receptors, making their single-channel currents more amenable to study...
  48. Statistical models to investigate long-distance QTL transcription regulation
    BARBARA ELIZABETH ENGELHARDT; Fiscal Year: 2011
    ..We will build these networks using Bayesian statistical models to compute the probability of a particular network with respect to each gene in the network jointly, with associated eQTLs providing ..
  49. NATIONAL CHILDREN'S STUDY
    William Hogan; Fiscal Year: 2013
    ..The NCS will employ a national probability sampling approach to select locations and participants for conduct of the study...
  50. Microenvironmental changes on NK cell responses to primary HSV-1
    Andrew J Tarr; Fiscal Year: 2011
    ..There are many factors that increase the severity and probability of reoccurrence, stress being one...
  51. NATIONAL CHILDREN'S STUDY
    Helen Koo; Fiscal Year: 2013
    ..The NCS will employ a national probability sampling approach to select locations and participants for conduct of the study...
  52. Impaired hippocampal function as a risk factor for Post-Traumatic Stress Disorder
    Almira Vazdarjanova; Fiscal Year: 2013
    ..Understanding the risk factors for developing PTSD can help reduce the probability of occurrence after experiencing emotional trauma...
  53. NATIONAL CHILDREN'S STUDY
    Kristina Lewis; Fiscal Year: 2013
    ..The NCS will employ a national probability sampling approach to select locations and participants for conduct of the study...
  54. NATIONAL CHILDREN'S STUDY SUPPORT
    Russell Walker; Fiscal Year: 2012
    ..The NCS will employ a national probability sampling approach to select locations and participants for conduct of the study...
  55. NATIONAL CHILDREN'S STUDY
    DANA DABALEA; Fiscal Year: 2012
    ..The NCS will employ a national probability sampling approach to select locations and participants for conduct of the study...
  56. SUPPORT OF THE NATIONAL CHILDREN'S STUDY INFORMATION SYSTEM
    JAMES TER MAAT; Fiscal Year: 2012
    ..The NCS will employ a national probability sampling approach to select locations and participants for conduct of the study...
  57. NATIONAL CHILDREN'S STUDY BIOMEDICAL (APPLIED/EXPLORATORY)
    Lee Smith; Fiscal Year: 2011
    ..The NCS will employ a national probability sampling approach to select locations and participants for conduct of the study...
  58. NATIONAL CHILDREN'S STUDY BIOMEDICAL (APPLIED/EXPLORATORY)
    Lee Smith; Fiscal Year: 2012
    ..The NCS will employ a national probability sampling approach to select locations and participants for conduct of the study...
  59. NATIONAL CHILDREN'S STUDY
    Helen Koo; Fiscal Year: 2012
    ..The NCS will employ a national probability sampling approach to select locations and participants for conduct of the study...
  60. The Abeta protein of Alzheimer's Disease is an antimicrobial peptide
    Robert D Moir; Fiscal Year: 2013
    ..We feel this line of enquiry has a high probability of yielding real and novel insights that will facilitate better strategies for ameliorating the pathological ..
  61. Integrative Cardiovascular Control During Exercise in Hypertension
    DONAL S O apos LEARY; Fiscal Year: 2010
    ..of any strenuous physical activity due to the dangerous elevations in arterial pressure which increase the probability of sudden, adverse cardiovascular events such as myocardial infarction and stroke...
  62. Using fMRI to Measure Negative Symptoms in Schizophrenia
    EDWARD E contact SMITH; Fiscal Year: 2010
    ..g., money), where the probability that each object leads to reward keeps changing slowly...
  63. TEST OF NEUTRAL MOLECULAR EVOLUTION
    Martin Kreitman; Fiscal Year: 1999
    ..teissieri and D. erecta - D. orena. Strictly neutral evolution is independent of population size, but the probability of fixation of slightly deleterious alleles is inversely proportional to population size and the probability of ..
  64. Unifying Mechanisms of Neurological Disorders: Scientific, Translational, and Cli
    JOAN MARIE CRANMER; Fiscal Year: 2010
    ..Neurotoxicology Conference is an annual event that focuses on a timely and provocative theme that has a high probability of advancing the field by being addressed by an interdisciplinary, international group of scientists in the ..
  65. Hurricane Katrina Community Advisory Group
    Ronald C Kessler; Fiscal Year: 2010
    ..The current research design is based on a probability sample of 3000 adults (ages 18+) who were residents of the areas affected by Hurricane Katrina and who were ..
  66. A RuleFit Product for Classification and Regression
    DAN STEINBERG; Fiscal Year: 2007
    ..output of RULEFIT is a numeric value reecting a prediction of the value of the dependent variable or the probability of a class membership. RULEFIT is likely to become a leading technique in the machine learning and statistics...
  67. GATING OF THE CFTR CL CHANNEL BY ATP HYDROLYSIS
    Tzyh Chang Hwang; Fiscal Year: 1999
    ..phosphorylation of the okadaic acid-insensitive site(s) enhances the channel activity by increasing the open probability. Further studies using nonhydrolyzable ATP analogs, AMP-PNP, and transition state phosphate analogs, vanadate ..
  68. Novel Treatment for Post-LASIK Ectasia
    MATTHEW MATTSON; Fiscal Year: 2009
    ..risk and high efficacy, patients in the "at risk" group might be treated prophylactically to greatly reduce the probability of subsequent ectasia...
  69. G2/M DNA DAMAGE CHECKPOINT IN BUDDING YEAST
    Ted Weinert; Fiscal Year: 2000
    ..Human checkpoint genes include p53 and ATM and mutations in these genes are associated with increased probability of developing cancer. Dr...
  70. DIAGNOSIS OF CHEST PAIN AND CARE IN RURAL HOSPITALS
    John Westfall; Fiscal Year: 2000
    ..The ACI-TIPI prints a probability score on the electrocardiogram report from 0-100% that the patient is truly suffering acute cardiac Ischemia...
  71. A Nanotechnology Enabled Point of Care Diagnostic Platform for Early Stage Cancer
    James Nelson; Fiscal Year: 2009
    ..Of cancers in males, the most common is prostate, with a probability of 1 in 6...