twin studies

Summary

Summary: Methods of detecting genetic etiology in human traits. The basic premise of twin studies is that monozygotic twins, being formed by the division of a single fertilized ovum, carry identical genes, while dizygotic twins, being formed by the fertilization of two ova by two different spermatozoa, are genetically no more similar than two siblings born after separate pregnancies. (Last, J.M., A Dictionary of Epidemiology, 2d ed)

Top Publications

  1. ncbi The equal environments assumption of classical twin studies may not hold
    Ken Richardson
    The Open University, UK
    Br J Educ Psychol 75:339-50. 2005
  2. ncbi Twin studies in Finland 2006
    Jaakko Kaprio
    Department of Public Health, University of Helsinki, FIN 00014 Helsinki, Finland
    Twin Res Hum Genet 9:772-7. 2006
  3. ncbi Twins as willing research participants: successes from studies nested within the California Twin Program
    Myles G Cockburn
    Department of Preventive Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089 9175, USA
    Twin Res Hum Genet 9:927-32. 2006
  4. ncbi Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies
    Patrick F Sullivan
    Department of Genetics, University of North Carolina at Chapel Hill, 27599, USA
    Arch Gen Psychiatry 60:1187-92. 2003
  5. ncbi Regression models for twin studies: a critical review
    John B Carlin
    Clinical Epidemiology and Biostatistics Unit, Murdoch Children s Research Institute, Royal Children s Hospital, Melbourne, Australia
    Int J Epidemiol 34:1089-99. 2005
  6. pmc Family and twin studies in inflammatory bowel disease
    Leena Halme
    Department of Transplantation and Liver Surgery, Helsinki University Hospital, Finland
    World J Gastroenterol 12:3668-72. 2006
  7. ncbi Genetics of food intake and body composition: lessons from twin studies
    K L Keller
    New York Obesity Research Center, St Luke s Roosevelt Hospital, Center College of Physicians and Surgeons, Columbia University, New York, USA
    Acta Diabetol 40:S95-100. 2003
  8. ncbi Norwegian Twin Registers and Norwegian twin studies--an overview
    A L Mina Bergem
    Department of Psychiatry, University of Oslo, Norway
    Twin Res 5:407-14. 2002
  9. ncbi Twin studies in pediatric depression
    Anita Thapar
    Child and Adolescent Psychiatry Section, Department of Psychological Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, Wales
    Child Adolesc Psychiatr Clin N Am 15:869-81, viii. 2006
  10. ncbi A test of the equal environment assumption (EEA) in multivariate twin studies
    Eske M Derks
    Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
    Twin Res Hum Genet 9:403-11. 2006

Detail Information

Publications235 found, 100 shown here

  1. ncbi The equal environments assumption of classical twin studies may not hold
    Ken Richardson
    The Open University, UK
    Br J Educ Psychol 75:339-50. 2005
    ..This interaction may further explain MZ-DZ correlation differences. There is abundant evidence for such interactive effects in published twin data. We suggest that there is a need for a more thorough examination of these problems...
  2. ncbi Twin studies in Finland 2006
    Jaakko Kaprio
    Department of Public Health, University of Helsinki, FIN 00014 Helsinki, Finland
    Twin Res Hum Genet 9:772-7. 2006
    ..This article describes current, ongoing data collection and analyses...
  3. ncbi Twins as willing research participants: successes from studies nested within the California Twin Program
    Myles G Cockburn
    Department of Preventive Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089 9175, USA
    Twin Res Hum Genet 9:927-32. 2006
    ..However, in most analyses, the participating sample of twins does not differ substantially from the underlying sample from the CTP. Future work will focus on improving methods of re-contacting cohort members...
  4. ncbi Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies
    Patrick F Sullivan
    Department of Genetics, University of North Carolina at Chapel Hill, 27599, USA
    Arch Gen Psychiatry 60:1187-92. 2003
    There are many published twin studies of schizophrenia...
  5. ncbi Regression models for twin studies: a critical review
    John B Carlin
    Clinical Epidemiology and Biostatistics Unit, Murdoch Children s Research Institute, Royal Children s Hospital, Melbourne, Australia
    Int J Epidemiol 34:1089-99. 2005
    b>Twin studies have long been recognized for their value in learning about the aetiology of disease and specifically for their potential for separating genetic effects from environmental effects...
  6. pmc Family and twin studies in inflammatory bowel disease
    Leena Halme
    Department of Transplantation and Liver Surgery, Helsinki University Hospital, Finland
    World J Gastroenterol 12:3668-72. 2006
    ..Disease concordance rates in IBD have been examined in multiplex families and in three large European twin studies.
  7. ncbi Genetics of food intake and body composition: lessons from twin studies
    K L Keller
    New York Obesity Research Center, St Luke s Roosevelt Hospital, Center College of Physicians and Surgeons, Columbia University, New York, USA
    Acta Diabetol 40:S95-100. 2003
    b>Twin studies are useful designs for decomposing genetic and environmental influences on traits, with the basic goal being to map variations in phenotypic similarity onto variances in genetic similarity...
  8. ncbi Norwegian Twin Registers and Norwegian twin studies--an overview
    A L Mina Bergem
    Department of Psychiatry, University of Oslo, Norway
    Twin Res 5:407-14. 2002
    ..Zygosity information is further obtained in the different twin studies derived from the twin register. In 1990 the whole register was made available in a computerized form...
  9. ncbi Twin studies in pediatric depression
    Anita Thapar
    Child and Adolescent Psychiatry Section, Department of Psychological Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, Wales
    Child Adolesc Psychiatr Clin N Am 15:869-81, viii. 2006
    Pediatric depression is an important clinical problem that is known to be familial. Twin studies have been used not only to examine the genetic etiology of depression but also to investigate developmental changes and gender effects, the ..
  10. ncbi A test of the equal environment assumption (EEA) in multivariate twin studies
    Eske M Derks
    Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
    Twin Res Hum Genet 9:403-11. 2006
    ..The number of twin pairs that is needed is no greater than the number typically available in most twin registries. The analysis of spatial ability and aggression indicated no detectable violation of the EEA...
  11. ncbi Classical twin studies and beyond
    Dorret Boomsma
    Department of Biological Psychology, Vrije Universiteit, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands
    Nat Rev Genet 3:872-82. 2002
    b>Twin studies have been a valuable source of information about the genetic basis of complex traits. To maximize the potential of twin studies, large, worldwide registers of data on twins and their relatives have been established...
  12. ncbi The role of genetic and environmental factors in the association between birthweight and blood pressure: evidence from meta-analysis of twin studies
    G McNeill
    College of Medicine and Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Int J Epidemiol 33:995-1001. 2004
    An inverse association between birthweight and later blood pressure has been found in many studies in singletons. Twin studies have been used to examine whether genetic factors or family environment could account for this association.
  13. ncbi Refractive errors in twin studies
    Mohamed Dirani
    Centre for Eye Research Australia, University of Melbourne, Australia Vision Cooperative Research Centre, Sydney, Australia
    Twin Res Hum Genet 9:566-72. 2006
    ..b>Twin studies (classical twin model) are commonly used to determine the weighting of genetic and environmental components in ..
  14. ncbi Metabolic and genetic influence on glucose metabolism in type 2 diabetic subjects--experiences from relatives and twin studies
    Henning Beck-Nielsen
    Odense University Hospital, Kloevervaenget 6, 4, 5000 Odense C, Denmark
    Best Pract Res Clin Endocrinol Metab 17:445-67. 2003
    ..The cellular mechanism responsible for obesity/lipid-induced diabetes mellitus is discussed with specific emphasis on the role of accumulation of long-chain AcylCoA and triglycerides in liver, muscle and beta-cells...
  15. ncbi The genetics of coronary heart disease: the contribution of twin studies
    Alun Evans
    Department of Epidemiology and Public Health, Queen s University Belfast, Belfast, Northern Ireland, UK
    Twin Res 6:432-41. 2003
    ..b>Twin studies have also contributed to our understanding of the life course hypothesis, and GenomEUtwin has the potential to ..
  16. ncbi Heritability of cortisol levels: review and simultaneous analysis of twin studies
    M Bartels
    Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
    Psychoneuroendocrinology 28:121-37. 2003
    ..Results of a simultaneous analysis of 5 comparable twin studies suggest a heritability of 62%...
  17. ncbi Eating disorders: from twin studies to candidate genes and beyond
    Margarita C T Slof-Op 't Landt
    Centrum Eetstoornissen Ursula, National Centre for Eating Disorders, Leidschendam, The Netherlands
    Twin Res Hum Genet 8:467-82. 2005
    ..b>Twin studies often focus on broader phenotypes or subthreshold eating disorders...
  18. ncbi Twin studies in behavioral research: a skeptical view
    Leon J Kamin
    Department of Psychology, University of Cape Town, Rondebosch, 7701, South Africa
    Theor Popul Biol 61:83-95. 2002
    ..The two studies agree in their conclusions, but we do not find the conclusions to be convincing. We suggest that no scientific purpose is served by the flood of heritability estimates generated by these studies...
  19. ncbi Analysis and interpretation of twin studies including measures of the shared environment
    Eric Turkheimer
    Department of Psychology, University of Virginia, Charlottesville 22904 4400, USA
    Child Dev 76:1217-33. 2005
    ....
  20. ncbi Has the "Equal Environments" assumption been tested in twin studies?
    Lindon Eaves
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298 0003, USA
    Twin Res 6:486-9. 2003
    ..The stratification approach to testing the equal environments assumption may be misleading and the results of such tests may actually be consistent with a simpler theory of the role of genetic factors in niche selection...
  21. ncbi Twins and friendship
    Karen Thorpe
    School of Early Childhood, Queensland University of Technology, Australia
    Twin Res 6:532-5. 2003
    ..The paper argues for the need to study the process and mechanisms in friendship formation among twin children because the findings might inform not only studies of friendship but also behavioural genetic research...
  22. ncbi The danish twin registry: past and present
    Bent Harvald
    The Danish Twin Registry, Epidemiology, Department of Public Health, University of Southern Denmark, Odense, Denmark
    Twin Res 7:318-35. 2004
    ..The Danish Twin Registry was established formally in 1954 and thus celebrates its 50th anniversary in 2004. Here we give an account of its founding and the early years, and a brief summary of more recent progress...
  23. ncbi Longitudinal stability of the CBCL-juvenile bipolar disorder phenotype: A study in Dutch twins
    Dorret I Boomsma
    Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
    Biol Psychiatry 60:912-20. 2006
    ..The purpose of this study is to assess the developmental stability of the CBCL-JBD phenotype across ages 7, 10, and 12 years in a large population-based twin sample and to examine its genetic architecture...
  24. ncbi Data collection on multiple births -- establishing twin registers and determining zygosity
    Kirsten Ohm Kyvik
    University of Southern Denmark, Institute of Public Health, Epidemiology, The Danish Twin Registry, JB Winsløwsvej 9B, Odense C
    Early Hum Dev 82:357-63. 2006
    ..The distribution of zygosity and chorionicity types among spontaneous and induced twin births are illustrated...
  25. ncbi Genetic and environmental influences on the fibrinolytic system: a twin study
    Dirk Peetz
    Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg University, Mainz, Germany
    Thromb Haemost 92:344-51. 2004
    ..This genetic influence is accounted for in large part but not completely by a limited number of polymorphisms within the respective genes associated with plasma levels of the gene products...
  26. ncbi Epigenetics and twins: three variations on the theme
    Arturas Petronis
    The Krembil Family Epigenetics Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto Ontario, M5T 1R8, Canada
    Trends Genet 22:347-50. 2006
    b>Twin studies have had a key role in the evaluation of heritability, a population-based estimate of the genetic contribution to phenotypic variation...
  27. ncbi Can we generalise from findings in twins?
    Ruth Morley
    Clinical Epidemiology and Biostatistics Unit, University of Melbourne Department of Paediatrics, and Murdoch Children s Research Institute, Royal Children s Hospital, Melbourne, Australia
    Paediatr Perinat Epidemiol 19:54-9. 2005
    ..The issue of whether findings from twin studies are generally informative, or whether factors associated with twinning preclude generalisation, is considered ..
  28. ncbi Genetic influence on inflammation variables in the elderly
    Moniek P M de Maat
    Department for Thrombosis Research, University of Southern Denmark, Esbjerg, Denmark
    Arterioscler Thromb Vasc Biol 24:2168-73. 2004
    ....
  29. ncbi Functional allelic heterogeneity and pleiotropy of a repeat polymorphism in tyrosine hydroxylase: prediction of catecholamines and response to stress in twins
    Lian Zhang
    Department of Medicine, University of California at San Diego, 92161, USA
    Physiol Genomics 19:277-91. 2004
    ....
  30. ncbi The Italian Twin Register: new cohorts and tools, current projects and future perspectives of a developing resource
    Corrado Fagnani
    National Center for Epidemiology, Surveillance and Health Promotion, Istituto Superiore di Sanita, 00161 Rome, Italy
    Twin Res Hum Genet 9:799-805. 2006
    ..The Italian Twin Register is currently involved in both population and clinical based studies on various complex phenotypes and diseases, some conducted within large European consortia...
  31. ncbi Prenatal programming of behavior: a twin-study perspective
    Richard J Rose
    Department of Psychology, Indiana University, Room 132, Psychology Bldg, 1101 East Tenth Street, Bloomington, IN 47405, USA
    Neurosci Biobehav Rev 29:321-7. 2005
    ..Twin comparisons, especially the comparisons of monozygotic co-twins, offer an informative and incisive approach for research on prenatal programming in humans...
  32. ncbi Heritability of polycystic ovary syndrome in a Dutch twin-family study
    J M Vink
    Department of Biological Psychology, Vrije Universiteit, Van de Boechorststraat 1, 1081 BT Amsterdam, The Netherlands
    J Clin Endocrinol Metab 91:2100-4. 2006
    ..Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among women of reproductive age. There is evidence for a genetic component in PCOS based on familial clustering of cases...
  33. ncbi The first "classical" twin study? Analysis of refractive error using monozygotic and dizygotic twins published in 1922
    Shiao Hui M Liew
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London SE1 7EH, United Kingdom
    Twin Res Hum Genet 8:198-200. 2005
    The first classical twin studies, recognizing the potential of comparing findings in identical twins, have previously been reported to be those by Siemens and by Merriman, both published in 1924...
  34. ncbi Future contributions on genetics
    Marie Odile Krebs
    INSERM E0117 Paris V, Universite Rene Descartes, Paris Hôpital Sainte Anne, 7 rue Cabanis, 75014 Paris, France
    World J Biol Psychiatry 6:49-55. 2005
    It has become obvious from epidemiological studies in families of patients affected or from twin studies, that most psychiatric disorders are in part genetically determined...
  35. ncbi Precision and bias of a normal finite mixture distribution model to analyze twin data when zygosity is unknown: simulations and application to IQ phenotypes on a large sample of twin pairs
    Beben Benyamin
    Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, King s Buildings, West Mains Road, Edinburgh, EH9 3JT, UK
    Behav Genet 36:935-46. 2006
    ..kurtosis of the pair difference may suggest that this assumption for analysis of quantitative trait in twin studies may be incorrect and needs revisiting...
  36. ncbi Registry of adolescent and young adult twins in the Tokyo area
    Chizuru Shikishima
    Department of Human Sciences, Faculty of Letters, Keio University, Japan
    Twin Res Hum Genet 9:811-6. 2006
    ..Adding an evolutionary psychology perspective to the behavior genetics framework is currently being attempted in order to develop a grand theory of human genetics...
  37. ncbi The Tokyo Twin Cohort Project: overview and initial findings
    Juko Ando
    Faculty of Letters, Keio University, Minato ku, Tokyo, Japan
    Twin Res Hum Genet 9:817-26. 2006
    ....
  38. ncbi Role of genetic and environmental influences on heart rate variability in middle-aged men
    A L T Uusitalo
    Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Kuopio, Kuopio, Finland
    Am J Physiol Heart Circ Physiol 293:H1013-22. 2007
    ..No single behavioral determinant appeared to have a major influence on HRV. The effects of medication and diseases may mask the minimal effect of occupational loading on HRV...
  39. ncbi Healthy Twin: a twin-family study of Korea--protocols and current status
    Joohon Sung
    Department of Preventive Medicine, Kangwon National University College of Medicine, Korea
    Twin Res Hum Genet 9:844-8. 2006
    ..We report study protocols and zygosity and the distribution of family size of the study participants...
  40. ncbi Wisconsin Twin Panel: current directions and findings
    Kathryn Lemery-Chalfant
    Department of Psychology, Arizona State University, Tempe, AZ 85281, USA
    Twin Res Hum Genet 9:1030-7. 2006
    ..Reported results highlight the utility of employing multiple modes of assessment when studying child development and psychopathology...
  41. ncbi Colorado Twin Registry
    Sally Ann Rhea
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO, USA
    Twin Res Hum Genet 9:941-9. 2006
    ..The development of the CTR is an ongoing and evolving process, and it has proved to be a valuable resource, relatively representative of the population from which it was drawn...
  42. ncbi The Florida State Twin Registry: research aims and design
    Jeanette E Taylor
    Department of Psychology, Florida State University, Tallahassee, FL, USA
    Twin Res Hum Genet 9:958-62. 2006
    ..Self-report questionnaires were included to assess maladaptive personality traits. Data sharing and future directions for growing the Florida State Twin Registry are discussed...
  43. ncbi The Michigan State University Twin Registry (MSUTR): genetic, environmental and neurobiological influences on behavior across development
    Kelly L Klump
    Department of Psychology, Michigan State University, East Lansing, MI 48824, USA
    Twin Res Hum Genet 9:971-7. 2006
    ..To date, we have collected data on over 1000 twins, with additional data collections underway. This article provides an overview of the newly developed MSUTR and describes current and future research directions...
  44. ncbi The National Longitudinal Study of Adolescent Health (Add Health) twin data
    Kathleen Mullan Harris
    Carolina Population Center, University of North Carolina at Chapel Hill, 123 W Franklin Street, Chapel Hill, NC 27516, USA
    Twin Res Hum Genet 9:988-97. 2006
    ..Add Health has an enlightened dissemination policy and to date has released phenotype and genotype data to more than 3000 researchers in the scientific community...
  45. ncbi Pittsburgh Registry of Infant Multiplets (PRIM): an update
    Elizabeth A Jenkins
    Department of Human Genetics, University of Pittsburgh, 707 Salk Hall, Pittsburgh, PA 15261, USA
    Twin Res Hum Genet 9:1006-8. 2006
    ..Pilot data on the heritability of minor physical anomalies and neuropsychological characteristics (Continuous Performance Test) are reported...
  46. ncbi Genes, environment, and time: the Vietnam Era Twin Study of Aging (VETSA)
    William S Kremen
    Department of Psychiatry, University of California San Diego, San Diego, CA, USA
    Twin Res Hum Genet 9:1009-22. 2006
    ....
  47. ncbi The Japanese Study of Adult Twins Reared Apart and Growing Old Separately
    Kazuo Hayakawa
    Department of Health Promotion Science, Faculty of Medicine, Osaka University, 1 7 Yamadaoka, Suita City, Osaka Fu, Japan
    Twin Res Hum Genet 9:806-7. 2006
    ....
  48. ncbi The Longitudinal Israeli Study of Twins (LIST): children's social development as influenced by genetics, abilities, and socialization
    Ariel Knafo
    Department of Psychology, The Hebrew University of Jerusalem, Jerusalem 91905, Israel
    Twin Res Hum Genet 9:791-8. 2006
    ..Other variables of interest such as children's temperament and parental values are discussed, as are ideas for further research...
  49. ncbi Semiparametric maximum likelihood variance component estimation using mixture moment structure models
    Kristian E Markon
    Department of Psychology, University of Minnesota, Minneapolis, 55455, USA
    Twin Res Hum Genet 9:360-6. 2006
    ..Semiparametric maximum likelihood estimation can be used with a variety of genetic models, can be extended to a variety of pedigree structures, and has various advantages over other approaches to modeling nonnormal data...
  50. ncbi Genetic and cultural transmission of antisocial behavior: an extended twin parent model
    Hermine H Maes
    Department of Human Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0003, USA
    Twin Res Hum Genet 10:136-50. 2007
    ..This study showed significant heritability, which is slightly increased by assortative mating, and significant effects of primarily nonparental shared environment on CD...
  51. ncbi Identification of twin pairs from large population-based samples
    Dinand Webbink
    CPB Netherlands Bureau for Economic Policy Analysis, The Hague, The Netherlands
    Twin Res Hum Genet 9:496-500. 2006
    The basis of most twin studies is the ascertainment of twins, often through twin registries, and determination of zygosity...
  52. ncbi A twin study of attention-deficit/hyperactivity disorder dimensions rated by the strengths and weaknesses of ADHD-symptoms and normal-behavior (SWAN) scale
    David A Hay
    School of Psychology, Curtin University of Technology, Perth, Western Australia
    Biol Psychiatry 61:700-5. 2007
    ..While this has major implications for genetic designs that require extremely discordant and concordant (EDAC) siblings, little is known of the genetics of scales which seek to differentiate within the "no ADHD symptom" group...
  53. ncbi [Twins: a response to the question of genetic/environmental influence on development?]
    Julia Cohen-Levy
    Faculté de chirurgie dentaire Université Paris VII, 5 rue GaranciBre, 75006 Paris, France
    Orthod Fr 78:63-7. 2007
    This article presents recent data about human twinning and explains how twin studies can bring precious informations about craniofacial growth...
  54. ncbi Chilean school-age children twin registry: planning, sampling and implications
    Daniza M Ivanovic
    Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile
    Twin Res Hum Genet 9:743-6. 2006
    ..4%). When DZ pairs were analyzed, 47.7% were of opposite sex, 20.1% were male pairs and 32.2% female pairs. In Chile, these findings represent a baseline study to contribute to the establishment of a national twin registry in the future...
  55. ncbi Current status of the Chinese National Twin Registry
    Liming Li
    Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, 38 Xueyuan Road, Haidian District, Beijing 100083, China
    Twin Res Hum Genet 9:747-52. 2006
    ..The current state and future plans for the Chinese National Twin Registry will be discussed in this article...
  56. ncbi The Cardiff Study of all Wales and North West of England Twins (CaStANET): a longitudinal research program of child and adolescent development
    Marianne B M van den Bree
    Department of Psychological Medicine, Cardiff University, Cardiff, United Kingdom
    Twin Res Hum Genet 10:13-23. 2007
    ....
  57. ncbi The Danish Twin Registry in the new millennium
    Axel Skytthe
    The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, J B Winløws Vej 9B, DK 5000 Odense C, Denmark
    Twin Res Hum Genet 9:763-71. 2006
    ..This paper summarizes the newest extension of the register and gives examples of new developments and phenotypes studied...
  58. ncbi HealthTwiSt: the Berlin Twin Registry
    Andreas Busjahn
    HealthTwiSt GmbH, Wiltbergstrasse 50H 134, 13125 Berlin, Germany
    Twin Res Hum Genet 9:778-82. 2006
    ..Some results are briefly described to give an impression of the range of research topics and related opportunities for retrospective and prospective collaborative research...
  59. ncbi The Jena Twin Registry and the Jena Twin Study of Social Attitudes (JeTSSA)
    Katharina Stössel
    Friedrich Schiller University Jena, Humboldtstrasse 11, D 07743 Jena, Germany
    Twin Res Hum Genet 9:783-6. 2006
    ..In addition, the effects of measured environmental variables on attitude formation are examined...
  60. pmc University of Washington Twin Registry: construction and characteristics of a community-based twin registry
    Niloofar Afari
    Department of Psychiatry, University of California San Diego, San Diego, CA, USA
    Twin Res Hum Genet 9:1023-9. 2006
    ..Plans for the further growth of the University of Washington Twin Registry and its use are discussed...
  61. ncbi Gray and white matter volume abnormalities in monozygotic and same-gender dizygotic twins discordant for schizophrenia
    Hilleke E Hulshoff Pol
    Rudolf Magnus Institute for Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Biol Psychiatry 55:126-30. 2004
    ....
  62. ncbi Major genetic susceptibility for venous thromboembolism in men: a study of Danish twins
    Torben Bjerregaard Larsen
    Department of Clinical Epidemiology, Aarhus University Hospital, Aalborg, Denmark
    Epidemiology 14:328-32. 2003
    ..Although several genetic determinants (mutations or polymorphisms) have been associated with increased risk of venous thromboembolism, the overall influence of genetic factors on this disease is unknown...
  63. ncbi Twinning
    Judith G Hall
    Department of Paediatrics, 4480 Oak Street, Room 2D19, British Columbia s Children s Hospital, BC, V6H 3V4, Vancouver, Canada
    Lancet 362:735-43. 2003
    ..b>Twin studies are used increasingly to study complex traits and disorders: however, caution is suggested, since twins might ..
  64. ncbi [Epidemiology of multiple sclerosis: environmental factors versus genetic factors]
    Jun Ichi Kira
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University
    Nihon Rinsho 61:1300-10. 2003
    ..The ratio of conventional to opticospinal MS has increased rapidly in Japanese born after 1960s, suggesting that the modernization occurred after 1960s in Japan has modifying effects on MS susceptibility and phenotypes...
  65. ncbi The value of twins in dental research
    G C Townsend
    Dental School, The University of Adelaide, Adelaide, South Australia
    Aust Dent J 48:82-8. 2003
    ..Current knowledge about the genetic bases of common dental problems is summarized and future directions in dental research involving twins are outlined...
  66. ncbi The Swedish Young Male Twins Study: a resource for longitudinal research on risk factors for obesity and cardiovascular diseases
    Finn Rasmussen
    Child and Adolescent Public Health Epidemiology Group, Department of Public Health Sciences, Karolinska Institute, Norrbacka, SE 171 76 Stockholm, Sweden
    Twin Res Hum Genet 9:883-9. 2006
    ....
  67. ncbi Chinese National Twin Registry as a resource for genetic epidemiologic studies of common and complex diseases in China
    Huiying Yang
    Division of Medical Genetics, Cedars Sinai Medical Center, UCLA School of Medicine, USA
    Twin Res 5:347-51. 2002
    ..We want to develop collaborations with investigators who have expertise in cancer, psychological disorders, and other disease areas...
  68. ncbi Genetic and environmental factors in complex diseases: the older Finnish Twin Cohort
    Jaakko Kaprio
    Dept of Public Health, University of Helsinki, National Public Health Institute, Helsinki, Finland
    Twin Res 5:358-65. 2002
    ..Finally, the inclusion of DNA-based genetic information in a phenotypically rich family data base will offer a unique resource for research in genetic epidemiology and behavioral medicine...
  69. ncbi The Norwegian Institute of Public Health Twin Panel: a description of the sample and program of research
    Jennifer R Harris
    The Norwegian Institute of Public Health, Division of Epidemiology, Oslo
    Twin Res 5:415-23. 2002
    ..This paper provides a brief overview of the data, sample, and the various research projects associated with this twin program of research...
  70. ncbi Netherlands Twin Register: a focus on longitudinal research
    Dorret I Boomsma
    Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
    Twin Res 5:401-6. 2002
    ..Large cohorts of phenotyped family members from the general population are very valuable for genetic epidemiological studies and permit selection of informative families for gene finding studies...
  71. ncbi The East Flanders Prospective Twin Survey (EFPTS)
    Catherine Derom
    Center of Human Genetics, University Hospital Gasthuisberg Katholieke Universiteit Leuven, Leuven, Belgium
    Twin Res 5:337-41. 2002
    ....
  72. ncbi Genetic and environmental factors in health-related behaviors: studies on Finnish twins and twin families
    Jaakko Kaprio
    Dept of Public Health, University of Helsinki, National Public Health Institute, Helsinki, Finland
    Twin Res 5:366-71. 2002
    ..Twin and twin-family studies with multiple measurements of risk factors and morbidity over time can permit a much more detailed assessment of the developmental dynamics of disease risk and the unfolding of behavioral risk factors...
  73. ncbi Familial mesial temporal lobe epilepsy: a benign epilepsy syndrome showing complex inheritance
    Douglas E Crompton
    Department of Medicine and Epilepsy Research Centre, University of Melbourne, Austin Health, West Heidelberg, Victoria, Australia
    Brain 133:3221-31. 2010
    ..of a genetic aetiology (rather than chance aggregation) in familial mesial temporal lobe epilepsy has come from twin studies. Dominant inheritance has been reported in two large families, though the usual mode of inheritance is not ..
  74. ncbi Cancer risk factors for selecting cohorts for large-scale chemoprevention trials
    P Greenwald
    Division of Cancer Prevention and Control, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cell Biochem Suppl 25:29-36. 1996
    ..Data from twin studies support the suggestion that environmental factors such as tobacco use significantly influence cancer risk...
  75. ncbi Genetics of dietary habits and obesity - a twin study
    Ann Louise Hasselbalch
    Institute of Preventive Medicine, Copenhagen University Hospitals, Denmark
    Dan Med Bull 57:B4182. 2010
    ..genetic influence on anthropometry has previously been established and has been estimated to be 60-70% based on twin studies. These inter-individual differences can, however, not explain the increase in obesity prevalence during the ..
  76. ncbi Recent progress in understanding the genetic susceptibility to osteoporosis
    J M Zmuda
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261, USA
    Genet Epidemiol 16:356-67. 1999
    Family and twin studies have established a genetic contribution to the etiology of osteoporosis...
  77. ncbi MSR1 variants and the risks of prostate cancer and benign prostatic hyperplasia: a population-based study in China
    Ann W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Carcinogenesis 28:2530-6. 2007
    Data from epidemiologic and twin studies suggest an important role of genetic susceptibility in prostate cancer...
  78. ncbi [Foetal programming of nutrition-related chronic diseases]
    Helene Delisle
    Departement de Nutrition, Universite de Montreal, CP 6128 Succ Centre Ville, Montreal QC H3C 3J7, Canada
    Sante 12:56-63. 2002
    ..Several, but not all, twin studies lend support to the hypothesis...
  79. pmc A case of autism with an interstitial deletion on 4q leading to hemizygosity for genes encoding for glutamine and glycine neurotransmitter receptor sub-units (AMPA 2, GLRA3, GLRB) and neuropeptide receptors NPY1R, NPY5R
    Subhadra Ramanathan
    Department of Pediatrics, University of California, Irvine, Irvine, CA, USA
    BMC Med Genet 5:10. 2004
    ..Although autism is etiologically heterogeneous, family and twin studies have established a definite genetic basis...
  80. ncbi A population-based study of chronic autoimmune hypothyroidism in Danish twins
    T H Brix
    Department of Endocrinology M, Odense University Hospital, Denmark
    J Clin Endocrinol Metab 85:536-9. 2000
    ..At present there are no population-based twin studies supporting such a genetic influence in the etiology of HT/AT...
  81. ncbi Osteoarthritis and osteoporosis: clinical and research evidence of inverse relationship
    Jan Dequeker
    Department of Rheumatology, University Hospitals K U Leuven, Leuven, Belgium
    Aging Clin Exp Res 15:426-39. 2003
    ..This increased BMD is related to high peak bone mass, as shown in mother-daughter and twin studies. With aging, the bone loss in OA is lower, except when measured near an affected joint (hand, hip, knee)...
  82. ncbi C-reactive protein, an 'intermediate phenotype' for inflammation: human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic/beta-adrenergic pathway loc
    Jennifer Wessel
    Department of Medicine, University of California at San Diego, California 92093 0838, USA
    J Hypertens 25:329-43. 2007
    ..C-reactive protein (CRP) both reflects and participates in inflammation, and its circulating concentration marks cardiovascular risk. Here we sought to understand the role of heredity in determining CRP secretion...
  83. ncbi Characterization by phenotype of families with atopic dermatitis
    M Bradley
    Department of Dermatology and Venereology, Karolinska Hospital, Karolinska Institutet, Stockholm, Sweden
    Acta Derm Venereol 80:106-10. 2000
    ..b>Twin studies indicate a strong genetic factor, but the susceptibility genes are unknown...
  84. ncbi Role of genes and environments for explaining Alzheimer disease
    Margaret Gatz
    Department of Psychology, University of Southern California, Los Angeles 90089 1061, USA
    Arch Gen Psychiatry 63:168-74. 2006
    b>Twin studies using selected samples have shown high heritability for Alzheimer disease (AD).
  85. ncbi The epidemiology of Graves' disease: evidence of a genetic and an environmental contribution
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
    J Autoimmun 34:J307-13. 2010
    Previous family and twin studies have indicated that Graves' disease has a heritable component...
  86. ncbi The influence of zygosity and chorion type on fat distribution in young adult twins consequences for twin studies
    R J Loos
    Faculty of Medicine, Department of Sport and Movement Sciences, Katholieke Universiteit, Leuven, Belgium
    Twin Res 4:356-64. 2001
    ..Therefore, we suggest that the chorion type of MZ twins does not bias the twin design and the estimation of the genetic contribution to adult anthropometry...
  87. ncbi A genetic "obesity risk index" for patients with morbid obesity
    Richard C Thirlby
    Virginia Mason Medical Center, 1100 Ninth Avenue, C6 SUR, P O Box 900, Seattle, WA 98111 0900, USA
    Obes Surg 12:25-9. 2002
    The influence of genetics on obesity is well established. Adoption studies and twin studies suggest that about 80% of the obesity risk is genetic...
  88. ncbi Influence of genes and family environment on adult smoking behavior assessed in an adoption study
    M Osler
    Institute of Public Health, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark
    Genet Epidemiol 21:193-200. 2001
    b>Twin studies suggest that genetic factors influence smoking behavior. However, in these studies, genetic and environmental influences may be confounded...
  89. ncbi Disruption of the circadian timing systems: molecular mechanisms in mood disorders
    Julien Mendlewicz
    Department of Psychiatry, Free University of Brussels, Brussels, Belgium
    CNS Drugs 23:15-26. 2009
    ..This paper reviews the molecular mechanisms involved in depression, with an emphasis on circadian genes. Twin studies in depression have reported probandwise concordance rates of 40% and 70% using narrow and broad diagnostic ..
  90. ncbi Effects of diet, drugs, and genes on plasma fibrinogen levels
    M P de Maat
    Gaubius Laboratory TNO PG, P O Box 2215, 2301 CE Leiden, The Netherlands
    Ann N Y Acad Sci 936:509-21. 2001
    ..Estimates, based on twin studies, suggest that 30-50% of the plasma fibrinogen level is genetically determined...
  91. ncbi Genetic predisposition, environment and cancer incidence: a nationwide twin study in Finland, 1976-1995
    P K Verkasalo
    Department of Public Health, University of Helsinki, Finland
    Int J Cancer 83:743-9. 1999
    b>Twin studies integrate genetic and environmental (including physical environment and life-style) information by comparing monozygotic and dizygotic twins for the occurrence of disease...
  92. ncbi Transporter associated with antigen processing and the chaperone tapasin: are non-classical HLA genes keys to the pathogenesis of schizophrenia?
    Barbara Fellerhoff
    Institute for Immunology, University of Munich, Goethestrasse 31, D 80336 Munich, Germany
    Med Hypotheses 72:535-8. 2009
    Schizophrenia is a mind-destructive disease. Family and twin studies have indicated an equal contribution of genetic endowment and environmental factors in the pathogenesis of schizophrenia...
  93. ncbi Redefining the HLA and RA association: to be or not to be anti-CCP positive
    Rene R P de Vries
    Department of Immunohematology and Bloodtransfusion, Leiden University Medical Center, Building 1, E3 Q, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands
    J Autoimmun 25:21-5. 2005
    ..Based on twin studies the contribution of genetic factors to the pathogenesis has been estimated to be about 60%...
  94. ncbi Genetic susceptibility to simple febrile seizures: interleukin-1beta promoter polymorphisms are associated with sporadic cases
    Ryutaro Kira
    Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Neurosci Lett 384:239-44. 2005
    ..A genetic predisposition to FSs is known, based on family studies, twin studies, and complex segregation analysis...
  95. ncbi Association study of neurotrophic tyrosine kinase receptor type 2 (NTRK2) and childhood-onset mood disorders
    Jennifer H Adams
    Department of Psychiatry, Cell and Molecular Division, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 132:90-5. 2005
    Childhood-onset mood disorders (COMD) are often familial, and twin studies of COMD provide compelling evidence that genetic factors are involved. Deficits in neural plasticity have been suggested to underlie the development of depression...
  96. ncbi Genetics of isolated and syndromic strabismus: facts and perspectives
    Birgit Lorenz
    Department of Pediatric Ophthalmology, Strabismology and Ophthalmogenetics, University of Regensburg, Germany
    Strabismus 10:147-56. 2002
    ..strabismus (prevalence in different populations 1-5%, positive family history in 37% on average), as have twin studies (mean concordance in monozygous twins 73% compared to 35% in dizygous twins)...
  97. ncbi beta2-adrenergic receptor activation and genetic polymorphisms in autism: data from dizygotic twins
    Susan L Connors
    Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, MD 21205, USA
    J Child Neurol 20:876-84. 2005
    ..Previous twin studies have shown strong genetic components for the development of autism, a disorder that can have multiple causes...
  98. ncbi Heritability and stability of resting blood pressure
    Jouke Jan Hottenga
    Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
    Twin Res Hum Genet 8:499-508. 2005
    ..influences to variation in resting systolic (SBP) and diastolic (DBP) blood pressure in participants from 4 twin studies carried out between 1986 and 2003. A total of 1577 subjects (682 males, 895 females) participated...
  99. ncbi Behavioral and physiological effects of an infant-neglect manipulation in a bi-parental, twinning primate: impact is dependent on familial factors
    Andrea C Dettling
    Behavioural Neurobiology Laboratory, Swiss Federal Institute of Technology Zurich, Schorenstrasse 16, CH 8603 Schwerzenbach, Switzerland
    Psychoneuroendocrinology 32:331-49. 2007
    ..b>Twin studies provide a powerful model with which to study such interactions...
  100. pmc Signs of developmental stuttering up to age eight and at 12 plus
    Peter Howell
    Department of Psychology and Centre for Human Communications, University College London, Gower St, London WC1E 6BT, England, UK
    Clin Psychol Rev 27:287-306. 2007
    ..b>Twin studies showed that environmental and host factors were split roughly 30/70 for both ages...
  101. ncbi Apolipoprotein B (APOB) gene polymorphism in patients with gallbladder disease
    Mateusz Kurzawski
    Department of Pharmacology, Pomeranian Medical University, Szczecin, Poland
    Arch Med Res 38:360-3. 2007
    ..However, twin studies provided strong evidence for a role of genetic factors in the disease pathogenesis...

Research Grants66

  1. GI Endotoxin as an Environmental Trigger in an alpha-Synuclein Transgenic Mouse
    Robert L Nussbaum; Fiscal Year: 2012
    ..The cause of most PD is unknown despite decades of research. Family studies, twin studies, and genetic association studies in Parkinson disease (PD) support the view that PD is a complex systemic ..
  2. Pathophysiology and Animal Model of Restless Legs Syndrome (RLS): Btbd9 Null Mic
    Yuqing Li; Fiscal Year: 2010
    ..Family and twin studies strongly support a genetic contribution to the pathogenesis of RLS...
  3. OLFACTORY RECEPTOR COPY NUMBER ASSOCIATION WITH AGE AT ONSET OF ALZHEIMER DISEASE
    Kinga Szigeti; Fiscal Year: 2013
    ..Heritability is estimated between 58 and 79% based on twin studies, including a large twin study from the Swedish Twin Registry...
  4. GENETIC EPIDEMIOLOGY OF NONALCOHOLIC FATTY LIVER DISEASE
    Rohit Loomba; Fiscal Year: 2013
    ..In order to gain expertise in genetic epidemiology and twin studies, a rigorous career development plan is proposed that benefits from a multi-disciplinary approach designed to ..
  5. Genetic and Molecular Mechanisms of Ethanol-Induced Developmental Defects
    RACHAEL LOUISE FRENCH; Fiscal Year: 2013
    ..Finally, while human epidemiological data, twin studies, and animal models indicate that genetic factors confer risk for and protection from fetal alcohol injury, no ..
  6. A twin study of obesity pathogenesis using fMRI
    Ellen A Schur; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Twin studies have provided decisive evidence for the hereditary nature of body weight regulation, demonstrating that individual differences in tendencies to gain weight can be explained by an ..
  7. Transgenerational effects of nicotine in F1 generation of exposed fathers in mice
    Markus Vallaster; Fiscal Year: 2013
    ..However, changes in the genome as determined in twin studies or detection of single nucleotide polymorphisms (SNPs) explain only part of the human heritability of nicotine ..
  8. Relation of Consummatory and Anticipatory Food Reward to Obesity
    Sonja Yokum; Fiscal Year: 2013
    Although twin studies imply that biological factors play a prominent role in the development of obesity, few prospective studies have identified biological factors that increase risk for future weight gain...
  9. Genetic Etiologies of Horizontal Strabismus
    Elizabeth C Engle; Fiscal Year: 2013
    ..Population, family-based, and twin studies all support a strong genetic contribution to CCS, with the relative risk to a first-degree relative of a ..
  10. Genetic Basis for susceptibility to EAE
    Vijay K Kuchroo; Fiscal Year: 2011
    ..Both familial aggregation and twin studies in MS and differences in EAE susceptibility in inbred strains of mice suggest a genetic component to these ..
  11. Understanding the genetic risk underlying racial disparities in uterine fibroids
    Digna R Velez Edwards; Fiscal Year: 2013
    ..and causal factors, especially since a genetic predisposition to fibroids has already been documented from twin studies. As much as 69% of risk is explained by genetic factors...
  12. In utero antidepressant exposures and risk for autism
    Roy H Perlis; Fiscal Year: 2013
    ..This result is consistent with twin studies indicating greater concordance for autism among dizygotic twins compared to non-twin siblings, likely pointing ..
  13. Building a Unique National Community Based Twin Repository
    Dedra S Buchwald; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The value of twin studies is well recognized at the National Institutes of Health (NIH) where an estimated 255 twin studies were funded in 2009...
  14. Cocaine Addiction and Retrotransposons
    Wade H Berrettini; Fiscal Year: 2013
    ..Although twin studies are consistent with an inherited component, it has been difficult to identify risk-increasing allels by ..
  15. Genetic risk factors for alcoholic cirrhosis - genome-wide case-control study
    John B Whitfield; Fiscal Year: 2013
    ..polymorphism (in PNPLA3) has shown replicable positive result as a risk factor for ALC, although evidence from twin studies and Inter-ethnic variability in ALC mortality rates, supports a genetic component in ALC...
  16. Gene Discovery in Familial Keratoconus
    Yutao Liu; Fiscal Year: 2013
    ..Family and twin studies including linkage analyses indicate the genetic contribution to the pathogenesis of keratoconus...
  17. NEUROCOGNITIVE CONSEQUENCES OF UNDERAGE DRINKING
    Andrey P Anokhin; Fiscal Year: 2012
    ..The sample will be drawn from ongoing epidemiological twin studies of the applicant and co-investigators, with selection of twin pairs based on already available data on the ..
  18. Human immunoglobulin Fc receptor functions in sarcoidosis
    Jianming Wu; Fiscal Year: 2013
    ..The critical role for geneti factors contributing to sarcoidosis etiology is strongly supported by twin studies, disease clustering in families, and racial differences in incidence rates...
  19. Genetic and behavioral effects on high-density lipoprotein: The Look AHEAD Study
    Jeanne M McCaffery; Fiscal Year: 2013
    ..genome-wide association studies (GWAS) have been successful in identifying markers associated with HDL and twin studies suggest that HDL response to behavioral intervention is heritable...
  20. AC1 and AC8 as Mediators of the Dendritic Response to Ethanol in a Model of FASD
    Laura Susick; Fiscal Year: 2013
    ..Fetal genotype has been shown to affect the severity of FASD as shown by twin studies, although the gene(s) involved have yet to be identified...
  21. Archiving the Vietnam Era Twin Studies of Aging (VETSA): New Uses for Old Data
    CAROL ELAINE FRANZ; Fiscal Year: 2013
    ..With our rapidly aging population, these data have potential for high public policy impact through the identification of risk and protective factors that may speed or delay cognitive and brain aging. ..
  22. Genome-wide association studies of prematurity and its complications
    Jeffrey C Murray; Fiscal Year: 2010
    ..Numerous family and twin studies provide strong evidence that genetic factors underlie about 40% of the risk for prematurity...
  23. High-Resolution Mapping of Susceptibility Genes for NIHL
    Rick A Friedman; Fiscal Year: 2013
    ..Pre-exposure diagnostics and the development of targeted therapies are sorely needed. Estimates from human twin studies suggest heritability for noise induced hearing loss (NIHL) of approximately 36% and although several candidate ..
  24. COHORT STUDY OF GENETIC SUSCEPTIBILITY TO BREAST CANCER
    DAVID JOHN HUNTER; Fiscal Year: 2010
    ..b>Twin studies have shown that telomere length has a substantial heritable component, however, no genetic variants have been ..
  25. A neuroimaging study of twin pairs with autism
    ANTONIO YOUSSEF HARDAN; Fiscal Year: 2013
    ..b>Twin studies in autism are particularly informative for examining the relative contribution of genetic and environmental ..
  26. Alcohol Involvement in Asian American Men and Women
    Tamara L Wall; Fiscal Year: 2010
    ..b>Twin studies comprised predominantly of participants of European Caucasian ancestry have shown genetic factors contribute 40-..
  27. Action Monitoring and Genomic Variants in Pediatric Obsessive-Compulsive Behavior
    Gregory L Hanna; Fiscal Year: 2013
    ..Both the CBCL-OCS and ERN show substantial heritability in pediatric twin studies. Although progress has been made in identifying electrophysiological and genetic factors associated with OC ..
  28. Regulation of activity-dependent ProSAp2 synaptic dynamics
    MAGALI HOLT ROWAN; Fiscal Year: 2011
    ..Though twin studies suggest a strong genetic component, mapping studies have failed to identify a single gene underling this ..
  29. Analysis of RORA and other candidate genes in PTSD
    Mark W Miller; Fiscal Year: 2013
    ..Numerous factors contribute to the probability of developing the disorder including heredity. Twin studies have shown that a 30-70% of variation in PTSD risk is explained by genetic factors...
  30. Child Behavior Checklist-Dysregulation Profile: Genes, Environment, &Life Course
    ROBERT RUSSELL ALTHOFF; Fiscal Year: 2013
    ..Dorret Boomsma, Professor at the Vrije University of Amsterdam and internationally known expert on twin studies and Dr. Thomas Achenbach, Professor at the University, of Vermont...
  31. Integrating contextual, proximal, and individual risks for child conduct problems
    S Alexandra Burt; Fiscal Year: 2013
    ..This "at-risk" twin sampling strategy constitutes a significant advance over current epidemiological twin studies in regards to studies of contextual risk, as such samples contain relatively few at-risk families...
  32. Understanding The Pathways To Aggression
    EMIL FRANK COCCARO; Fiscal Year: 2012
    ..To gain a better understanding of these potential genetic mechanisms, twin studies can be used to identify biologically-based traits that may serve as endophenotpyes for aggression and related ..
  33. The genomic bridge project (GBP)
    Elise B Robinson; Fiscal Year: 2013
    ..Dr. Robinson has a background in behavior genetics (twin studies) and the epidemiology of childhood behavioral disorders, but no training in the use of measured genetic ..
  34. Gene-Environment Interplay of Social Contexts and Aging-Related Outcomes
    Nancy L Pedersen; Fiscal Year: 2013
    ..We will establish a consortium of seven longitudinal twin studies to explore the basis for the association of social factors and aging outcomes...
  35. Fine Mapping Susceptibility Loci for Nicotine Dependence
    Ming D Li; Fiscal Year: 2013
    ..Our previous meta-analysis of reported twin studies indicated that the weighted mean heritability for ND is 56% in adult smokers...
  36. Cognitive Endophenotypes for Genetic Studies of Alzheimer's Disease
    Kathleen M Hayden; Fiscal Year: 2011
    ..plan will also benefit from the input of collaborators Carl Pieper (biostatistics), Brenda Plassman (twin studies), and David Steffens (geriatric depression) as she strives to understand and develop latent models within the ..
  37. Twin Studies of the Marriage Benefit: Parsing Selection from Causation
    Robert E Emery; Fiscal Year: 2013
    ....
  38. Identification of susceptibility genes for Essential Tremor
    Elan D Louis; Fiscal Year: 2013
    ..highly-genetic disorder, with physicians commonly seeing families with affecteds over multiple generations, and twin studies showing high concordance among monozygotes...
  39. Gene-by-Environment Interactions, Social Stress, and Depression in Older Adults
    Mark A Whisman; Fiscal Year: 2013
    ..There has been considerable interest in evaluating such gene-by-environment interactions, including twin studies that have examined latent genetic influences and candidate gene studies that have evaluated the potential ..
  40. Robust Test for Genetic Effect in Presence of Interaction with Age-At-First-Drink
    Tatiyana V Apanasovich; Fiscal Year: 2013
    ..b>Twin studies have recently demonstrated that age at first drink moderates genetic influences on alcohol dependence...
  41. Neurobiological Signatures of Social Dysfunction and Repetitive Behavior
    Jeremy Veenstra-Vanderweele; Fiscal Year: 2013
    ..We need new treatments based upon an understanding of pathophysiology. Twin studies identify ASD as the most heritable behaviorally defined disorder...
  42. International Collaborative Twin Study of Refractive and Glaucoma Endophenotypes
    Terri Young; Fiscal Year: 2009
    ..We have created an international collaboration of large complementary twin studies, from the USA, Australia, and United Kingdom...
  43. Etiology and Neuropsychology of Math, Reading, ADHD, and their Covariation
    Erik G Willcutt; Fiscal Year: 2013
    ..and Math Project and the International Longitudinal Twin Study of Early Reading Development, two longitudinal twin studies that have followed population-based samples of twins since preschool...
  44. Whole genome sequencing of bipolar disorder and schizophrenia
    PAMELA contact SKLAR; Fiscal Year: 2010
    ..Family and twin studies have conclusively established that heritable factors play the major role in SCZ and BPD risk, and GWAS studies ..
  45. Genetic Linkage Analysis of Barrett's Esophagus
    Yvonne Romero; Fiscal Year: 2005
    ..reflux symptoms are 4-fold more likely to have erosive esophagitis compared to non-symptomatic controls; 2) Twin studies showing the heritable attributable risk of GERD symptoms to be 31%; and, with the support of an initial K23 ..
  46. Neurobiological Underpinnings of Math and Reading Comorbidity: A Twin Study
    Stephen A Petrill; Fiscal Year: 2013
    ..Project (Years 1 to 4) integrates structural and functional brain imaging within two ongoing longitudinal twin studies to address two Specifc Aims...
  47. Early Brain Development in Twins
    John H Gilmore; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Twin studies have been critical in determining the contributions of genetic and environmental factors to normal brain structure and for understanding abnormalities of brain development that underlie ..
  48. Twin, molecular, and developmental approaches to understanding alcohol misuse
    Danielle M Dick; Fiscal Year: 2013
    ..This will be accomplished by integrating findings across twin studies, gene identification projects, and longitudinal, community-based samples...
  49. The Bipolar Genome Study
    NICHOLAS JOSEPH SCHORK; Fiscal Year: 2013
    ..Though family and twin studies support strong heritability, progress towards identifying specific genes has been slow...
  50. Gene-enviornment interactions in facial clefts
    Kaare Christensen; Fiscal Year: 2006
    ..Family and twin studies have clearly indicated a genetic role in the etiology of cleft lip and palate, but environmental components ..
  51. Brain Lactate and Photic Stimulation in Panic Disorder
    RICHARD MADDOCK; Fiscal Year: 2005
    Panic disorder is a potentially disabling anxiety disorder affecting 1.5% to 3.5% of the population. Twin studies show that panic disorder has a significant heritable component...
  52. Genetically-informed designs of externalizing behavior and romantic relationships
    Jessica Salvatore; Fiscal Year: 2013
    ..Thus, this work uses complementary genetically-informed methods (twin studies and gene identification methods) to determine the extent to which genetic and/or environmental influences ..
  53. GENETIC ANALYSIS OF PSORIASIS
    Anne Bowcock; Fiscal Year: 2001
    ..The mode of inheritance of psoriasis is complex, although a familial component is now accepted as a result of twin studies, sib pair studies, the identification of large numbers of multiply affected families, and more recently, by ..
  54. JOB COMPLEXITY AND COGNITION IN OLDER TWIN PAIRS
    Guy Potter; Fiscal Year: 2003
    ..b>Twin studies allow for control of many of these confounding factors...
  55. Genetics of Mammographic Density in Ashkenazi Jews
    Elad Ziv; Fiscal Year: 2013
    ..cancer and is also a highly heritable trait with ~60-70% of the variance in due to genetic factors based on twin studies. MD is also higher in families with a strong history of breast cancer...
  56. Adenovirus & Human Obesity - Longitudinal & Twin Studies
    Richard Atkinson; Fiscal Year: 2001
    ..The potential impact on worldwide public health may be enormous. ..
  57. Genetic Elements that Influence Susceptibility to CNS Autoimmunity
    Ana C Anderson; Fiscal Year: 2010
    ..Both familial aggregation and twin studies in MS and the difference in the susceptibility to EAE in inbred strains of mice suggest a genetic component to ..
  58. Annual Meeting of the ADHD Molecular Genetics Network
    Stephen V Faraone; Fiscal Year: 2013
    ..Because family and twin studies suggest that ADHD has a substantial genetic component, several research groups have been pursuing molecular ..
  59. Discordant MZ twins in craniofacial gene discovery
    Jeffrey Murray; Fiscal Year: 2006
    ..Early on, twin studies proved very fruitful in confirming a strong heritable component of CLP but twins have not been used directly in ..
  60. Genetics of Anorexia Nervosa
    Manfred Fichter; Fiscal Year: 2005
    ..In addition to environmental influence, family and twin studies demonstrate substantial heritability for AN...
  61. Molecular Genetic Study of Sexual Orientation
    Alan Sanders; Fiscal Year: 2007
    Family and twin studies support a significant genetic component in the trait of male homosexuality, one of the most fundamental variations in normal human sexuality...
  62. PACIFIC GENETIC EPIDEMIOLOGIC STUDY ON AGING
    J Curb; Fiscal Year: 2002
    DESCRIPTION: (Abstract from application) Epidemiological, family, and twin studies suggest that a substantial proportion of the phenotypic variation in longevity and functional ability is genetic...
  63. LINKAGE STUDY OF PANIC DISORDER
    Raymond Crowe; Fiscal Year: 1999
    Background: Family and twin studies indicate that panic disorder is a genetic disease. These data indicate that the genes could act either independently, by either a dominant or a recessive model, or additively...
  64. BORNA DISEASE VIRUS AND NEUROPSYCHIATRIC DISEASE
    WALTER LIPKIN; Fiscal Year: 2002
    ..Although a genetic component is likely, discordance for disease in monozygotic twin studies and epidemiology suggest the presence of cofactors. One candidate risk factor is brain infection...
  65. Genetics of Anorexia Nervosa
    Bernie Devlin; Fiscal Year: 2006
    ..In addition to environmental influence, family and twin studies demonstrate substantial heritability for AN...
  66. Genetics of Anorexia Nervosa
    Michael Strober; Fiscal Year: 2005
    ..In addition to environmental influence, family and twin studies demonstrate substantial heritability for AN...