random allocation

Summary

Summary: A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.

Top Publications

  1. ncbi Generation of allocation sequences in randomised trials: chance, not choice
    Kenneth F Schulz
    Family Health International, PO Box 13950, Research Triangle Park, NC 27709, USA
    Lancet 359:515-9. 2002
  2. ncbi Bias in causal estimates from Mendelian randomization studies with weak instruments
    Stephen Burgess
    MRC Biostatistics Unit, University of Cambridge, Cambridge, U K
    Stat Med 30:1312-23. 2011
  3. ncbi Allocation concealment in randomised trials: defending against deciphering
    Kenneth F Schulz
    Family Health International, PO Box 13950, 27709, Research Triangle Park, NC, USA
    Lancet 359:614-8. 2002
  4. pmc Adaptive trial designs: a review of barriers and opportunities
    John A Kairalla
    Department of Biostatistics, University of Florida, PO Box 117450, Gainesville, FL 32611 7450, USA
    Trials 13:145. 2012
  5. ncbi Statistical comparison of random allocation methods in cancer clinical trials
    Atsushi Hagino
    Department of Industrial Management and Engineering, Faculty of Engineering, Tokyo University of Science, Tokyo, Japan
    Control Clin Trials 25:572-84. 2004
  6. pmc SERCA2a gene therapy restores microRNA-1 expression in heart failure via an Akt/FoxO3A-dependent pathway
    Regalla Kumarswamy
    Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Eur Heart J 33:1067-75. 2012
  7. ncbi Comparison of angiogenic potency between mesenchymal stem cells and mononuclear cells in a rat model of hindlimb ischemia
    Takashi Iwase
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Cardiovasc Res 66:543-51. 2005
  8. ncbi The method of minimization for allocation to clinical trials. a review
    Neil W Scott
    Department of Public Health, University of Aberdeen, Aberdeen, UK
    Control Clin Trials 23:662-74. 2002
  9. ncbi Different methods of allocation to groups in randomized trials are associated with different levels of bias. A meta-epidemiological study
    Peter Herbison
    Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, PO Box 913, Dunedin 9054, New Zealand
    J Clin Epidemiol 64:1070-5. 2011
  10. ncbi The landscape and lexicon of blinding in randomized trials
    Kenneth F Schulz
    Family Health International, Box 13950, Research Triangle Park, NC 27709, USA
    Ann Intern Med 136:254-9. 2002

Detail Information

Publications349 found, 100 shown here

  1. ncbi Generation of allocation sequences in randomised trials: chance, not choice
    Kenneth F Schulz
    Family Health International, PO Box 13950, Research Triangle Park, NC 27709, USA
    Lancet 359:515-9. 2002
    ..Investigators should devote appropriate resources to the generation of properly randomised trials and reporting their methods clearly...
  2. ncbi Bias in causal estimates from Mendelian randomization studies with weak instruments
    Stephen Burgess
    MRC Biostatistics Unit, University of Cambridge, Cambridge, U K
    Stat Med 30:1312-23. 2011
    ..We discuss ways to analyse Mendelian randomization studies to alleviate the problem of weak instrument bias...
  3. ncbi Allocation concealment in randomised trials: defending against deciphering
    Kenneth F Schulz
    Family Health International, PO Box 13950, 27709, Research Triangle Park, NC, USA
    Lancet 359:614-8. 2002
    ..Without it, even properly developed random allocation sequences can be subverted...
  4. pmc Adaptive trial designs: a review of barriers and opportunities
    John A Kairalla
    Department of Biostatistics, University of Florida, PO Box 117450, Gainesville, FL 32611 7450, USA
    Trials 13:145. 2012
    ..However, the interested reader will find that we provide current references to focused reviews and original theoretical sources which lead to details of the current state of the art in theory and practice...
  5. ncbi Statistical comparison of random allocation methods in cancer clinical trials
    Atsushi Hagino
    Department of Industrial Management and Engineering, Faculty of Engineering, Tokyo University of Science, Tokyo, Japan
    Control Clin Trials 25:572-84. 2004
    ..In conclusion, both the statistical and clinical validity of minimization was demonstrated in our study...
  6. pmc SERCA2a gene therapy restores microRNA-1 expression in heart failure via an Akt/FoxO3A-dependent pathway
    Regalla Kumarswamy
    Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Eur Heart J 33:1067-75. 2012
    ..We studied the effects of therapeutic AAV9.SERCA2a gene therapy on cardiac miRNome expression and focused on regulation, expression, and function of miR-1 in reverse remodelled failing hearts...
  7. ncbi Comparison of angiogenic potency between mesenchymal stem cells and mononuclear cells in a rat model of hindlimb ischemia
    Takashi Iwase
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Cardiovasc Res 66:543-51. 2005
    ..Accordingly, we injected equal numbers of MSC or MNC in a rat model of hindlimb ischemia and compared their therapeutic potential...
  8. ncbi The method of minimization for allocation to clinical trials. a review
    Neil W Scott
    Department of Public Health, University of Aberdeen, Aberdeen, UK
    Control Clin Trials 23:662-74. 2002
    ..From the evidence presented in this review, we believe minimization to be a highly effective allocation method and recommend its wider adoption in the conduct of randomized controlled trials...
  9. ncbi Different methods of allocation to groups in randomized trials are associated with different levels of bias. A meta-epidemiological study
    Peter Herbison
    Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, PO Box 913, Dunedin 9054, New Zealand
    J Clin Epidemiol 64:1070-5. 2011
    ..Insecure hiding of the treatment allocation in randomized trials is associated with bias. It is less certain how much bias is associated with different methods of treatment allocation...
  10. ncbi The landscape and lexicon of blinding in randomized trials
    Kenneth F Schulz
    Family Health International, Box 13950, Research Triangle Park, NC 27709, USA
    Ann Intern Med 136:254-9. 2002
  11. ncbi Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cells
    Wei Gen Li
    Department of Internal Medicine, Cardiovascular Division, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Circulation 109:2221-6. 2004
    ....
  12. ncbi Successful transplant of mesenchymal stem cells in induced osteonecrosis of the ovine femoral head: preliminary results
    Matheus Levi Tajra Feitosa
    Department of Surgery, Faculty of Veterinary Medicine and Animal Science, USP, Sao Paulo, Brazil
    Acta Cir Bras 25:416-22. 2010
    ..Evaluate the bone tissue recovery following transplantation of ovine mesenchymal stem cells (MSC) from bone marrow and human immature dental-pulp stem cells (hIDPSC) in ovine model of induced osteonecrosis of femoral head (ONFH)...
  13. pmc Prior exercise training does not prevent acute cardiac alterations after myocardial infarction in female rats
    Eduardo C A Veiga
    Department of Medicine, Cardiology division Universidade Federal de São Paulo Escola Paulista de Medicina, Sao Paulo, SP, Brazil
    Clinics (Sao Paulo) 66:889-93. 2011
    ..This study aimed to investigate whether previous exercise training could prevent or attenuate acute cardiac alterations after myocardial infarction...
  14. ncbi Habitual low-intensity exercise does not protect against myocardial dysfunction after ischemia in rats
    Joseph W Starnes
    Department of Kinesiology and Health Education, Cardiac Metabolism Laboratory, University of Texas, Austin, Texas 78712, USA
    Eur J Cardiovasc Prev Rehabil 12:169-74. 2005
    ..Thus, the purpose of this study is to determine whether low-intensity exercise provides self-protection to the heart against I-R injury...
  15. ncbi Influence of thermal stress on marginal integrity of restorative materials
    Maximiliano Sergio Cenci
    Dental School of Piracicaba, State University of Campinas, Piracicaba, SP, Brazil
    J Appl Oral Sci 16:106-10. 2008
    ..05). Marginal integrity was more affected in AM restorations under thermal cycling stress, whereas RC and GI ionomer restoration margins were only significantly affected only under longer dwell times...
  16. ncbi Effect of palatable hyperlipidic diet on lipid metabolism of sedentary and exercised rats
    Debora Estadella
    Department of Physiology, Universidade Federal de Sao Paulo EPM, Biomedical Science Building, Rua Botucatu 862, Vila Clementino, 04023 060 São Paulo, SP, Brazil
    Nutrition 20:218-24. 2004
    ....
  17. pmc Peroxynitrite mediates diabetes-induced endothelial dysfunction: possible role of Rho kinase activation
    Azza B el-Remessy
    College of Pharmacy, The University of Georgia, 1120 15th Street, HM 1200, Augusta, GA 30912, USA
    Exp Diabetes Res 2010:247861. 2010
    ..Together, peroxynitrite can suppress eNOS expression via activation of RhoA and hence cause vascular dysfunction...
  18. ncbi Postconditioning attenuates myocardial ischemia-reperfusion injury by inhibiting events in the early minutes of reperfusion
    Hajime Kin
    Department of Cardiothoracic Surgery, The Carlyle Fraser Heart Center Crawford Long Hospital, Emory University School of Medicine, Atlanta, GA 30308 2225, USA
    Cardiovasc Res 62:74-85. 2004
    ..This study tested the hypothesis that the early minutes of reperfusion (R) during which postconditioning (Post-con) is applied are critical to its cardioprotection...
  19. ncbi A generic minimization random allocation and blinding system on web
    Hongwei Cai
    Network Center, Fourth Military Medical University, No 17 Changle West Road, Xi an, Shaanxi 710032, China
    J Biomed Inform 39:706-19. 2006
    ..Minimization random allocation system integrated with blinding function that could facilitate the implementation of this method in general ..
  20. pmc CR8, a selective and potent CDK inhibitor, provides neuroprotection in experimental traumatic brain injury
    Shruti V Kabadi
    Department of Anesthesiology, Center for Shock, Trauma, and Anesthesiology Research STAR, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Neurotherapeutics 9:405-21. 2012
    ..Given the increased potency and efficacy of CR8 as compared to earlier purine analog types of CDK inhibitors, this drug should be considered as a candidate for future clinical trials of TBI...
  21. ncbi Toll-like receptor 9 agonist IMO cooperates with cetuximab in K-ras mutant colorectal and pancreatic cancers
    Roberta Rosa
    Dipartmento di Endocrinologia ed Oncologia Molecolare e Clinica, Universita di Napoli Federico II, Naples, Italy
    Clin Cancer Res 17:6531-41. 2011
    ....
  22. ncbi Exercise protects cardiac mitochondria against ischemia-reperfusion injury
    Youngil Lee
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
    Med Sci Sports Exerc 44:397-405. 2012
    ....
  23. ncbi Dose and time response after intraamniotic endotoxin in preterm lambs
    B W Kramer
    Division of Pulmonary Biology, Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA
    Am J Respir Crit Care Med 164:982-8. 2001
    ..The cells in the amniotic fluid may be a source of prolonged fetal exposure to proinflammatory cytokines...
  24. ncbi Voluntary exercise in C57 mice is anxiolytic across several measures of anxiety
    Jasmin N Salam
    Department of Psychology, University of Vermont, 2 Colchester Avenue, Burlington, VT 05405, USA
    Behav Brain Res 197:31-40. 2009
    ..Given the consistency of the anxiolytic effect of voluntary exercise across several measures, it is now possible to begin a systematic analysis of the physiological basis of the anxiolytic effect of exercise...
  25. ncbi Relationship between objective and subjective assessment of limb function in normal dogs with an experimentally induced lameness
    Andrew S Waxman
    College of Veterinary Medicine, Iowa State University, Ames, IA, USA
    Vet Surg 37:241-6. 2008
    ..To evaluate the relationship between previously used subjective and objective measures of limb function in normal dogs that had an induced lameness...
  26. ncbi Protective effects of selenium (Se) and zinc (Zn) on cadmium (Cd) toxicity in the liver and kidney of the rat: histology and Cd accumulation
    El Heni Jihen
    Unité de Recherche Eléments Traces, Radicaux Libres, Antioxydants, Pathologies Humaines et Environnement, Departement de Biophysique, Faculte de medecine de Monastir, Tunisie
    Food Chem Toxicol 46:3522-7. 2008
    ..With Se and Zn simultaneous treatment during Cd exposure, the observed morphological changes had practically disappeared from the liver, but were only reduced in the kidney...
  27. ncbi Effect of cyclopentanone prostaglandin 15-deoxy-delta12,14PGJ2 on early functional recovery from experimental spinal cord injury
    Tiziana Genovese
    IRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy
    Shock 30:142-52. 2008
    ..Taken together, our results clearly demonstrate that treatment with 15d-PGJ2 reduces the development of inflammation and tissue injury associated with spinal cord trauma...
  28. ncbi Effect of ghrelin on septic shock in rats
    Lin Chang
    Cardiovascular Research Institute, The First Hospital of Peking University, Beijing 100034, China
    Acta Pharmacol Sin 24:45-9. 2003
    ..To study the role of ghrelin in the late stage of septic shock in rats...
  29. ncbi Adenovirus-mediated peroxisome proliferator activated receptor gamma overexpression prevents nutritional fibrotic steatohepatitis in mice
    Yue Min Nan
    Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University, Shijiazhuang, China
    Scand J Gastroenterol 46:358-69. 2011
    ..We aim to elucidate the effect and the mechanism of PPARγ itself on nutritional fibrotic steatohepatitis in mice...
  30. ncbi Cardioprotective effect of polydatin against ischemia/reperfusion injury: roles of protein kinase C and mito K(ATP) activation
    Qing Miao
    Institute of Materia Medica, School of Pharmacy, Fourth Military Medical University, 17 Changle West Road, 710032 Xi an, Shaanxi, PR China
    Phytomedicine 19:8-12. 2011
    ..We therefore conclude that PPC exerts cardioprotective effect by the activation of PKC-K(ATP)-dependent signaling and the direct anti-oxidative stress mechanisms...
  31. ncbi A peptide inhibitor of C-jun N-terminal kinase modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation
    Mark Lehnert
    Department of Trauma Surgery, JW Goethe University, Frankfurt, Germany
    Shock 30:159-65. 2008
    ..These changes are mediated, at least in part, by JNK. Therefore, JNK inhibition deserves further evaluation as a potential treatment option in patients after resuscitated blood loss...
  32. ncbi Recirculating cardiac delivery of AAV2/1SERCA2a improves myocardial function in an experimental model of heart failure in large animals
    M J Byrne
    Heart Failure Research Group, Baker Heart Research Institute, Melbourne, Victoria, Australia
    Gene Ther 15:1550-7. 2008
    ..As such, AAV2/1SERCA2a elicits favourable functional and molecular actions when delivered in a mechanically targeted manner in an experimental model of HF. These observations lay a platform for potential clinical translation...
  33. pmc Random allocation software for parallel group randomized trials
    Mahmood Saghaei
    Department of Anaesthesia, Isfahan University of Medical Sciences, Isfahan, Iran
    BMC Med Res Methodol 4:26. 2004
    ..The main objective of the Random Allocation Software project was to enhance the user's control over different aspects of randomization in parallel group ..
  34. ncbi A new rating scale for open-field evaluation of behavioral recovery after cervical spinal cord injury in rats
    Marina Martinez
    Neurosciences Intégratives et Adaptatives, UMR 6149, Universite de Provence CNRS, Marseille, France
    J Neurotrauma 26:1043-53. 2009
    ..See online Supplementary Material (scoring spreadsheet and videotape recordings) at www.liebertonline.com...
  35. pmc Hypothermia and postconditioning after cardiopulmonary resuscitation reduce cardiac dysfunction by modulating inflammation, apoptosis and remodeling
    Patrick Meybohm
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Kiel, Germany
    PLoS ONE 4:e7588. 2009
    ..This study sought to examine whether hypothermia and the combination of hypothermia and pharmacological postconditioning are cardioprotective in a model of cardiopulmonary resuscitation following acute myocardial ischemia...
  36. pmc Escape of intraluminal platelets into brain parenchyma after subarachnoid hemorrhage
    V Friedrich
    Department of Neuroscience, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY, USA
    Neuroscience 165:968-75. 2010
    ..Three-dimensional analysis suggests that platelet aggregates initiate or stimulate local disruption of endothelium and destruction of adjacent basal lamina after SAH...
  37. pmc Luminal platelet aggregates in functional deficits in parenchymal vessels after subarachnoid hemorrhage
    Victor Friedrich
    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Brain Res 1354:179-87. 2010
    ....
  38. ncbi Design and analysis of an Actinobacillus pleuropneumoniae transmission experiment
    A G J Velthuis
    Quantitative Veterinary Epidemiology Group, Institute for Animal Science and Health, Wageningen University and University Utrecht, PO Box 65, 8200 AB Lelystad, The Netherlands
    Prev Vet Med 60:53-68. 2003
    ..Although it could not be demonstrated that vaccination has an effect on the susceptibility of pigs, it was demonstrated that nasal excretion of A. pleuropneumoniae is related to the infectivity of pigs...
  39. ncbi Electrophysiological evidence for two steps in syntactic analysis. Early automatic and late controlled processes
    A Hahne
    Max Plank Institute of Cogniive Neuroscience, InselstraBe 22 26, D 04103 Leipzig, Germany
    J Cogn Neurosci 11:194-205. 1999
    ..This data pattern suggests that first-pass parsing processes are automatic, whereas second-pass parsing processes are under participants' strategic control...
  40. ncbi Effect of niacin on LXRalpha and PPARgamma expression and HDL-induced cholesterol efflux in adipocytes of hypercholesterolemic rabbits
    Shui Ping Zhao
    Department of Cardiology, The Second Xiangya Hospital of Central South University, Middle Ren Min Road No 86, Changsha, Hunan 410011, PR China
    Int J Cardiol 124:172-8. 2008
    ..The aim of this study was to evaluate the effect of niacin on LXRalpha and PPARgamma expression and HDL-induced cholesterol efflux in adipocytes from hypercholesterolemic rabbits...
  41. pmc Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathway
    Mary D L Chau
    Cardiovascular and Metabolism Disease Area, Novartis Institute for Biomedical Research, Inc, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 107:12553-8. 2010
    ....
  42. ncbi The use of unequal randomisation ratios in clinical trials: a review
    J C Dumville
    Area 4, York Trials Unit, Department of Health Sciences, University of York, York, YO10 5DD, United Kingdom
    Contemp Clin Trials 27:1-12. 2006
    ..To examine reasons given for the use of unequal randomisation in randomised controlled trials (RCTs)...
  43. pmc Sepsis causes neuroinflammation and concomitant decrease of cerebral metabolism
    Alexander Semmler
    Department of Neurology, University Bonn, Bonn, Germany
    J Neuroinflammation 5:38. 2008
    ..Changes in cerebral blood flow, release of inflammatory molecules and metabolic alterations contribute to neuronal dysfunction and cell death...
  44. ncbi Excessive tumor necrosis factor activation after infarction contributes to susceptibility of myocardial rupture and left ventricular dysfunction
    Mei Sun
    Heart and Stroke Richard Lewar Centre of Excellence, University of Toronto, and University Health Network, Toronto, Ontario, Canada
    Circulation 110:3221-8. 2004
    ....
  45. pmc Repeated mild traumatic brain injury: mechanisms of cerebral vulnerability
    Mayumi L Prins
    Department of Neurosurgery, University of California, School of Medicine, Los Angeles, CA 90095, USA
    J Neurotrauma 30:30-8. 2013
    ..Results suggest that the duration of metabolic depression reflects the time-course of vulnerability to second injury in the juvenile brain and could serve as a valuable biomarker in establishing window of vulnerability guidelines...
  46. pmc Blood contamination effect on shear bond strength of an orthodontic hydrophilic resin
    Taís de Morais Alves da Cunha
    Dental School, Pontifical Catholic University of Parana, Curitiba, PR, Brazil
    J Appl Oral Sci 20:89-93. 2012
    ..The aim of this study was to assess the impact of blood contamination on shear bond strength (SBS) and bond failure pattern of metallic brackets bonded using a new hydrophilic resin...
  47. ncbi Variable tidal volumes improve lung protective ventilation strategies in experimental lung injury
    Peter M Spieth
    Department of Anesthesiology and Intensive Care Therapy, University Hospital Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Am J Respir Crit Care Med 179:684-93. 2009
    ..Noisy ventilation with variable Vt may improve respiratory function in acute lung injury...
  48. ncbi Factors related to colonic fermentation of nondigestible carbohydrates of a previous evening meal increase tissue glucose uptake and moderate glucose-associated inflammation
    Marion G Priebe
    Center for Medical Biomics, University Medical Center Groningen, University of Groningen, The Netherlands
    Am J Clin Nutr 91:90-7. 2010
    ..This phenomenon is linked to colonic fermentation of nondigestible carbohydrates, but the underlying mechanism is not fully elucidated...
  49. ncbi Dried plum reverses bone loss in an osteopenic rat model of osteoporosis
    Farzad Deyhim
    Department of Nutritional Sciences, 301 Human Environmental Sciences, Oklahoma State University, Stillwater, 74078 6141, USA
    Menopause 12:755-62. 2005
    ..The present study evaluated whether dried plum was able to restore bone mass in osteopenic ovariectomized rats...
  50. ncbi Quercetin ameliorates cardiovascular, hepatic, and metabolic changes in diet-induced metabolic syndrome in rats
    Sunil K Panchal
    Department of Biological and Physical Sciences, University of Southern Queensland, Toowoomba, Queensland, Australia
    J Nutr 142:1026-32. 2012
    ..Thus, quercetin treatment attenuated most of the symptoms of metabolic syndrome, including abdominal obesity, cardiovascular remodeling, and NAFLD, with the most likely mechanisms being decreases in oxidative stress and inflammation...
  51. ncbi Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis
    Yaojiong Wu
    161 HMRC, University of Alberta, 113 Street and 87 Avenue, Edmonton, Alberta T6G 2E1, Canada
    Stem Cells 25:2648-59. 2007
    ..Thus, our data suggest that BM-MSCs promote wound healing through differentiation and release of proangiogenic factors. Disclosure of potential conflicts of interest is found at the end of this article...
  52. ncbi The oxidation handicap hypothesis and the carotenoid allocation trade-off
    C Alonso-Alvarez
    Instituto de Investigacion en Recursos Cinegeticos, IREC, CSIC, UCLM, JCCM, Ciudad Real, Spain
    J Evol Biol 21:1789-97. 2008
    ..The trade-off was apparently solved by reducing redness, allowing increased carotenoid availability, which could have contributed to buffer oxidative stress...
  53. ncbi Acute cardiopulmonary effects of a dual-endothelin receptor antagonist on oleic acid-induced pulmonary arterial hypertension in dogs
    Ling Wang
    Research Institute of Respiratory Diseases and Department of Surgical Intensive Care Unit, Zhongshan Hospital, Fudan University, Shanghai, China
    Exp Lung Res 30:31-42. 2004
    ..Thus, dual-ET receptor antagonists such as Tezosentan may be useful in the management of acute pulmonary arterial hypertension, complicating the course of OA-induced lung injury...
  54. ncbi Videoendoscopic endotracheal intubation in the rat: a comprehensive rodent model of laparoscopic surgery
    Joseph M Fuentes
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Surg Res 122:240-8. 2004
    ..Current nonventilated rodent models of laparoscopy do not manage the CO(2) load of pneumoperitoneum, but ventilated surgical rodent models are invasive (tracheotomy) and may independently induce the inflammatory response...
  55. pmc Effect of sesamin on serum cholesterol and triglycerides levels in LDL receptor-deficient mice
    José L Peñalvo
    Institute for Preventive Medicine, Nutrition and Cancer, Folkhalsan Research Center and Division of Clinical Chemistry, University of Helsinki, Finland
    Eur J Nutr 45:439-44. 2006
    ....
  56. pmc Nutrition intervention: a strategy against systemic inflammatory syndrome
    Helieh S Oz
    Center for Oral Health Research, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    JPEN J Parenter Enteral Nutr 33:380-9. 2009
    ....
  57. pmc Changes in articular cartilage after meniscectomy and meniscus replacement using a biodegradable porous polymer implant
    Gerjon Hannink
    Orthopaedic Research Lab, Department of Orthopaedics, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Knee Surg Sports Traumatol Arthrosc 19:441-51. 2011
    ..To evaluate the long-term effects of implantation of a biodegradable polymer meniscus implant on articular cartilage degeneration and compare this to articular cartilage degeneration after meniscectomy...
  58. ncbi Biodegradable three-dimension micro-device delivering 5-fluorouracil in tumor bearing mice
    Xiaojiao Ren
    School of Medicine, Xi an Jiaotong University, Xi an 710061, PR China
    Drug Deliv 19:36-44. 2012
    ..These results suggested that the three-dimensional micro-device may provide a promising local and controlled release drug delivery system, which may enable delivery of multiple drugs for post-surgical chemotherapy against solid tumor...
  59. ncbi Effects of resistance training on matrix metalloproteinase-2 activity and biomechanical and physical properties of bone in ovariectomized and intact rats
    G E Shiguemoto
    Laboratory of Exercise Physiology, Federal University of Sao Carlos UFSCar, Sao Carlos, Sao Paulo, SP, Brazil
    Scand J Med Sci Sports 22:607-17. 2012
    ..On the other hand, ovariectomy reduced the activity of MMP-2 and produced deleterious effects on bone tissue, mimicking menopause intrinsically...
  60. ncbi Adjuvant and immuno-suppressive effect of six monophthalates in a subcutaneous injection model with BALB/c mice
    S T Larsen
    National Institute of Occupational Health, Lersø Parkallé 105, 2100, Copenhagen, Denmark
    Toxicology 169:37-51. 2001
    ..No statistically significant immune modulating effect was seen with MBnP and MnBP...
  61. ncbi Environmental enrichment results in cortical and subcortical changes in levels of synaptophysin and PSD-95 proteins
    Jess Nithianantharajah
    Department of Anatomy and Cell Biology, University of Melbourne, Melbourne, Victoria 3010, Australia
    Neurobiol Learn Mem 81:200-10. 2004
    ....
  62. ncbi Polydatin modulates inflammation by decreasing NF-κB activation and oxidative stress by increasing Gli1, Ptch1, SOD1 expression and ameliorates blood-brain barrier permeability for its neuroprotective effect in pMCAO rat brain
    Hui Ji
    Department of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, PR China
    Brain Res Bull 87:50-9. 2012
    ....
  63. ncbi Postconditioning inhibits mitochondrial permeability transition
    Laurent Argaud
    INSERM E 0226, Universite Claude Bernard Lyon I, France
    Circulation 111:194-7. 2005
    ..quot; After reflow, opening of the mitochondrial permeability transition pore (mPTP) has been involved in lethal reperfusion injury. We hypothesized that postconditioning may modulate mPTP opening...
  64. ncbi Effect of continuous versus dichotomous outcome variables on study power when sample sizes of orthopaedic randomized trials are small
    Mohit Bhandari
    Department of Clinical Epidemiology and Biostatistics, McMaster University Medical Centre, 1200 Main Street West, Room 2C12, Hamilton, Ontario L8N 3Z5, Canada
    Arch Orthop Trauma Surg 122:96-8. 2002
    ..6%, p=0.04). When orthopaedic surgeons anticipate small sample sizes for their study, they can optimize their study's statistical power by choosing a continuous outcome variable...
  65. ncbi Object memory in young and aged mice after sevoflurane anaesthesia
    Andreas Wiklund
    Department of Anaesthesiology, Surgical Services and Intensive Care Medicine, Karolinska University Hospital, Stockholm, Sweden
    Neuroreport 20:1419-23. 2009
    ..Sevoflurane anaesthesia thus causes memory impairment in mice regardless of beta2 receptor-mediated nicotinic cholinergic neurotransmission...
  66. ncbi The role of the hippocampus in memory for the temporal order of a sequence of odors
    Raymond P Kesner
    Department of Psychology, University of Utah, Salt Lake City 84112, USA
    Behav Neurosci 116:286-90. 2002
    ..However, the HIP group could discriminate between the odors. The data suggest that the hippocampus is involved in separating sensory events in time so that I event can be remembered separately from another event...
  67. ncbi Momordica charantia (bitter melon) reduces plasma apolipoprotein B-100 and increases hepatic insulin receptor substrate and phosphoinositide-3 kinase interactions
    Pratibha V Nerurkar
    Laboratory of Metabolic Disorders and Alternative Medicine, Department of Molecular Biosciences and Bioengineering, College of Tropical Agriculture and Human Resources, University of Hawaii at Manoa, Honolulu, HI 96816, USA
    Br J Nutr 100:751-9. 2008
    ..Investigating the biochemical and molecular mechanisms involved in amelioration of diabetic dyslipidaemia by BMJ may lead to identification of new molecular targets for dietary/alternative therapies...
  68. ncbi Postconditioning by xenon and hypothermia in the rat heart in vivo
    Christian Schwiebert
    Department of Anaesthesiology, University of Amsterdam, Amsterdam, The Netherlands
    Eur J Anaesthesiol 27:734-9. 2010
    ..We investigated whether xenon, administered prior to hypothermia or simultaneously with hypothermia, also protects the rat heart from reperfusion injury...
  69. ncbi Adequate intake values for dietary fibre based on faecal bulking indexes of 66 foods
    J A Monro
    New Zealand Institute for Crop and Food Research, Palmerston North, New Zealand
    Eur J Clin Nutr 58:32-9. 2004
    ..To determine an adequate daily intake value for dietary fibre (AIdf) based on faecal bulking indexes (FBIs) for 66 foods of known total dietary fibre (TDF) content...
  70. pmc Transcriptional regulation of β-secretase-1 by 12/15-lipoxygenase results in enhanced amyloidogenesis and cognitive impairments
    Jin Chu
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Ann Neurol 71:57-67. 2012
    ..12/15-Lipoxygenase (12/15-LO) is an enzyme widely distributed in the central nervous system, and it has been involved in the neurobiology of Alzheimer disease (AD). However, the mechanism involved remains elusive...
  71. ncbi Neural substrates for the effects of rehabilitative training on motor recovery after ischemic infarct
    R J Nudo
    Department of Neurobiology and Anatomy, University of Texas Health Science Center at Houston, 77030, USA
    Science 272:1791-4. 1996
    ....
  72. pmc Aerobic interval training enhances cardiomyocyte contractility and Ca2+ cycling by phosphorylation of CaMKII and Thr-17 of phospholamban
    Ole J Kemi
    Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    J Mol Cell Cardiol 43:354-61. 2007
    ..These observations indicate that calcium/calmodulin-dependent kinase IIdelta contributes significantly to the functional adaptation of the cardiomyocyte to regular exercise training...
  73. ncbi Mendelian randomization as an instrumental variable approach to causal inference
    Vanessa Didelez
    Department of Statistical Science, University College London, UK
    Stat Methods Med Res 16:309-30. 2007
    ..This framework allows us to address limitations of the Mendelian randomization technique that have often been overlooked in the medical literature...
  74. pmc Vagal sparing surgical technique but not stoma size affects body weight loss in rodent model of gastric bypass
    Marco Bueter
    Imperial Weight Centre, Department of Investigative Medicine, Hammersmith Hospital, Imperial College London, Du Cane Road, London W12 0NN, UK
    Obes Surg 20:616-22. 2010
    ..The aim of this study was to evaluate whether gastric bypass with or without vagal preservation resulted in a different outcome...
  75. ncbi Gene expression analysis after prenatal tracheal ligation in fetal rat as a model of stimulated lung growth
    Carmen Mesas-Burgos
    Astrid Lindgren s Children Hospital, Division for Pediatric Surgery, Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden
    J Pediatr Surg 44:720-8. 2009
    ..To increase understanding of the biological mechanisms involved in growth stimulation after TL in the fetal lung, we performed Global gene expression analysis using microarray technology...
  76. ncbi Preslaughter handling effects on pork quality and glycolytic potential in two muscles differing in fiber type composition
    E Hambrecht
    Nutreco Swine Research Centre, Boxmeer, The Netherlands
    J Anim Sci 83:900-7. 2005
    ..Conversely, oxidative muscle types tend to have higher ultimate pH values and produce DFD pork in response to intense physical activity and/or high psychological stress levels preslaughter...
  77. pmc The effect of eurycoma longifolia Jack on spermatogenesis in estrogen-treated rats
    Norhazlina Abdul Wahab
    Department of Physiology, Faculty of Medicine, UKM Medical Molecular Biology Institute UMBI, Universiti Kebangsaan Malaysia
    Clinics (Sao Paulo) 65:93-8. 2010
    ..The aim of the present study was to determine the effect of EL on testicular histology and sperm count in estrogen-treated male rats...
  78. pmc Neonatal overfeeding alters adult anxiety and stress responsiveness
    Sarah J Spencer
    Department of Physiology, Faculty of Medicine, Monash University, Melbourne, Victoria 3800, Australia
    Psychoneuroendocrinology 34:1133-43. 2009
    ..Thus, while neonatal litter size affects long-term body weight regulation, it can also alter long-term activity, anxiety and stress responsiveness, and the degree to which it does so appears to be sex-dependent...
  79. ncbi Effect of fluoridated bleaching gels on the remineralization of predemineralized bovine enamel in vitro
    Peter Tschoppe
    Department of Operative Dentistry and Periodontology, University School of Dental Medicine, CharitéCentrum 3, Germany
    J Dent 37:156-62. 2009
    ..This study evaluated possible differences regarding the remineralization of predemineralized enamel after exposure to fluoridated or non-fluoridated bleaching gels...
  80. ncbi Effects of in-office and at-home bleaching on human enamel and dentin: an in vitro application of Fourier transform infrared study
    Feride Severcan
    Department of Biology, Middle East Technical University, 06531 Ankara, Turkey
    Appl Spectrosc 62:1274-9. 2008
    ..Therefore, at-home bleaching seems to be much safer than in-office bleaching in terms of molecular variations...
  81. ncbi Adverse effects of the antiangiogenic agent angiostatin on the healing of experimental colonic anastomoses
    Elisabeth A te Velde
    Department of Surgery, University Medical Center Utrecht, The Netherlands
    Ann Surg Oncol 9:303-9. 2002
    ..Surgeons will encounter more patients undergoing such therapy. Therefore, it is essential to know the effects of antiangiogenic agents on physiological angiogenesis, as occurs during the healing of colonic anastomoses...
  82. ncbi Beneficial effects of hydroxyapatite on enamel subjected to 30% hydrogen peroxide
    Tao Jiang
    Key Laboratory for Oral Biomedical Engineering, Ministry of Education, School and Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Wuhan 430079, PR China
    J Dent 36:907-14. 2008
    ..To evaluate the effect of combination of hydroxyapatite (HA) and hydrogen peroxide (HP) on color, microhardness and morphology of human tooth enamel...
  83. ncbi Role of c-Jun N-terminal kinase in early brain injury after subarachnoid hemorrhage
    Hiroshi Yatsushige
    Department of Physiology, Loma Linda University, Loma Linda, California 92354, USA
    J Neurosci Res 85:1436-48. 2007
    ..This study demonstrates a multitude of beneficial effects of JNK inhibition, including protection of the neurovascular unit in early brain injury after SAH...
  84. ncbi Effect of transportation stress on heat shock protein 70 concentration and mRNA expression in heart and kidney tissues and serum enzyme activities and hormone concentrations of pigs
    Hong Yu
    Key Laboratory of Animal Physiology and Biochemistry, Department of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China
    Am J Vet Res 68:1145-50. 2007
    ..To determine the enzymatic and hormonal responses, heat shock protein 70 (Hsp70) production, and Hsp70 mRNA expression in heart and kidney tissues of transport-stressed pigs...
  85. ncbi Genes of the antioxidant response undergo upregulation in a rodent model of nonalcoholic steatohepatitis
    Andrew J Lickteig
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA
    J Biochem Mol Toxicol 21:216-20. 2007
    ..These data strongly indicate that the pathology induced by the MCD dietary model of NASH results in upregulation of the antioxidant response in rats...
  86. ncbi Role of myofibroblasts, macrophages, transforming growth factor-beta endothelin, angiotensin-II, and fibronectin in the progression of tubulointerstitial nephritis induced by gentamicin
    Tufik J Geleilete
    Department of Internal Medicine, Faculty of Medicine, Ribeirao Preto, SP, Brazil
    J Nephrol 15:633-42. 2002
    ....
  87. ncbi Potential agents to control enamel caries-like lesions
    F C Rehder Neto
    Department of Restorative Dentistry, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil
    J Dent 37:786-90. 2009
    ..To assess whether pastes containing casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and calcium sodium phosphosilicate (CSP) control artificial caries lesion progression...
  88. ncbi Estrogen attenuates the adventitial contribution to neointima formation in injured rat carotid arteries
    S Oparil
    Cardiovasc Res 44:608-14. 1999
    ....
  89. ncbi Effects of cleavable PEG-cholesterol derivatives on the accelerated blood clearance of PEGylated liposomes
    Huan Xu
    College of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, PR China
    Biomaterials 31:4757-63. 2010
    ..Consequently, these two cleavable PEG-lipid derivatives may not only prolong the circulation time of nanoparticles, but may also represent a solution to the ABC phenomenon...
  90. ncbi Involvement of opioid receptors in electroacupuncture-produced anti-hyperalgesia in rats with peripheral inflammation
    Rui Xin Zhang
    Complementary Medicine Program, Center for Integrative Medicine, University of Maryland, 3rd Floor, James Kernan Hospital Mansion, 2200 Kernan Drive, Baltimore, MD 21207, USA
    Brain Res 1020:12-7. 2004
    ..These results suggest selective involvement of mu and delta, but not kappa, receptors in EA-produced anti-hyperalgesia in rats. A combined EA and opioid drug protocol may provide an improved treatment strategy for inflammatory pain...
  91. ncbi Human recombinant erythropoietin significantly improves tumor oxygenation independent of its effects on hemoglobin
    Kimberly L Blackwell
    Division of Medical Oncology, Department of Medicine, Duke University Comprehensive Cancer Center, Erwin Road, Durham, NC 27710, USA
    Cancer Res 63:6162-5. 2003
    ..These data confirm that tumor oxygenation in nonanemic individuals may be improved through the administration of EPO, and this improvement appears to be independent of HgB effects...
  92. ncbi A comparative study on the effect of nicotine administration and cigarette smoke inhalation on bone healing around titanium implants
    João B César-Neto
    Department of Prosthodontics and Periodontics, Division of Periodontics, School of Dentistry at Piracicaba, UNICAMP, Piracicaba, Sao Paulo, Brazil
    J Periodontol 74:1454-9. 2003
    ..This study proposes to investigate the impact of two conditions, i.e., nicotine administration and cigarette smoke inhalation, on the healing around implants...
  93. pmc Utilization of insecticide-treated nets by under-five children in Nigeria: assessing progress towards the Abuja targets
    Olusola B Oresanya
    National Malaria Control Programme, Federal Ministry of Health, 2nd Floor, Yobe House, First Avenue, Off Shehu Shagari Way, Maitama, Abuja, Nigeria
    Malar J 7:145. 2008
    ..The survey was the first nationally representative study of ITN use assessing progress towards the Abuja target amongst vulnerable groups...
  94. ncbi Exercise induces early and late myocardial preconditioning in dogs
    Raúl Domenech
    Department of Pathophysiology, Biomedical Sciences Institute, Faculty of Medicine, University of Chile, Casilla 16038, Santiago 9, Chile
    Cardiovasc Res 55:561-6. 2002
    ..We tested the hypothesis that exercise induces myocardial preconditioning in dogs...
  95. pmc Immediate post-shock chest compressions improve outcome from prolonged ventricular fibrillation
    Robert A Berg
    The University of Arizona College of Medicine, Sarver Heart Center, Tucson, AZ 85724 5017, USA
    Resuscitation 78:71-6. 2008
    ..e., delayed post-shock compressions) associated with AED use...
  96. pmc Moderate alcohol consumption increases insulin sensitivity and ADIPOQ expression in postmenopausal women: a randomised, crossover trial
    M M Joosten
    Business Unit Biosciences, TNO Quality of Life, P O Box 360, 3700 AJ, Zeist, The Netherlands
    Diabetologia 51:1375-81. 2008
    ..To determine whether 6 weeks of daily, moderate alcohol consumption increases expression of the gene encoding adiponectin (ADIPOQ) and plasma levels of the protein, and improves insulin sensitivity in postmenopausal women...
  97. ncbi Dopamine transporter and D2 receptor binding densities in mice prone or resistant to chronic high fat diet-induced obesity
    Xu Feng Huang
    Department of Biomedical Science, University of Wollongong, NSW 2522, Australia
    Behav Brain Res 175:415-9. 2006
    ..D2 receptor density was significantly lower in the rostral part of caudate putamen in cDIO mice compared to cDR and LF mice...
  98. pmc Ascorbic acid protects against restraint stress-induced memory deficits in Wistar rats
    Raju Suresh Kumar
    Department of Physiology, Melaka Manipal Medical College, International Centre for Health Sciences, Manipal University Manipal, Karnataka, India
    Clinics (Sao Paulo) 64:1211-7. 2009
    ..The present work was designed to study the protective effects of ascorbic acid in memory loss induced by chronic restraint stress...
  99. ncbi Minimization--reducing predictability for multi-centre trials whilst retaining balance within centre
    Sarah Brown
    Clinical Trials Research Unit, University of Leeds, 17 Springfield Mount, Leeds LS2 9NG, UK
    Stat Med 24:3715-27. 2005
    ..Minimization incorporating a random element of 0.80 is the most efficient method to use based upon the simulations undertaken in this study of real clinical trial data using different probabilities of allocation...
  100. ncbi Long-term alterations in neuroimmune responses after neonatal exposure to lipopolysaccharide
    Lysa Boisse
    Calgary Brain Institute, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    J Neurosci 24:4928-34. 2004
    ..Thus, neonatal LPS can alter CNS-mediated inflammatory responses in adult rats...
  101. ncbi Lay conceptions of the ethical and scientific justifications for random allocation in clinical trials
    Elizabeth J Robinson
    Department of Psychology, Keele University, Keele, Staffs ST5 5BG, UK
    Soc Sci Med 58:811-24. 2004
    ..recognise scientific benefits of random allocation to treatment conditions in a trial...

Research Grants62

  1. Transfusion Trigger Trial in Coronary Artery Disease: A Pilot Study
    JEFFREY LEE CARSON; Fiscal Year: 2010
    ..The patient must have a hemoglobin concentration less than 10 g/dL at the time of random allocation to liberal (10 g/dL threshold) transfusion strategy or restrictive (<8 g/dL or symptoms)...
  2. Phthalates in Drugs and Male Genital Malformation
    Allen A Mitchell; Fiscal Year: 2012
    ..are often included in some, but not all, drugs used for a given indication, a situation that mimics random allocation;further, like other inactive ingredients, the presence of phthalates is unlikely to be known to either ..
  3. Impact of Sunflower Oil Massage on Neonatal Mortality in Nepal
    Luke C Mullany; Fiscal Year: 2013
    ..Women will also be provided with either sunflower seed oil or mustard oil, depending on the random allocation of their cluster of residence...
  4. A lipid-based approach towards a high-resolution structure of a functional nAChR
    Jose Lasalde-Dominicci; Fiscal Year: 2013
    ..Thus, the proposed research is relevant to NIH's mission in that it will increase current knowledge about an important ligand-gated ion channel which could help extend healthy life and reduce the burdens of illness. ..
  5. Neighborhood Characteristics and Body Mass Index: Selection or Causation?
    Ken Smith; Fiscal Year: 2009
    ..Achieving this objective will help us to better understand the ways in which policy-makers can alter neighborhood environments in order to reduce overweight or obesity risks among Americans. ..
  6. Cancer Genome Characterization Center at Johns Hopkins
    Stephen Baylin; Fiscal Year: 2009
    ..This project has direct relevance to public health. Precise knowledge of the type and frequency of the major cancer causing alterations will allow the best molecular targets to be selected for new therapy development. ..
  7. A Nicotine Biosensor for Addiction Studies
    Peter A Petillo; Fiscal Year: 2013
    ..abstract_text> ..
  8. Enhancing Psychological Capital to Foster Health Outcomes in Homeless Young Women
    DONNA LYNN REW; Fiscal Year: 2013
    ..Findings will be used to revise the intervention manual and research protocol for a larger multi-site test of the intervention using a randomized controlled trial design. ..
  9. Mechanisms of Statin-Induced DM in JUPITER (Rosuvasatin for CVD Prevention)
    ARUNA DAS PRADHAN; Fiscal Year: 2013
    ..The relative risk of diabetes associated with random allocation to rosuvastatin in JUPITER was 1.26 (1.05-1.51;p=0.02)...
  10. Randomized observation study of biologic therapy for rheumatoid arthritis
    LARRY W contact MORELAND; Fiscal Year: 2010
    ....
  11. The Mental Health and Well-Being of Adolescent Children of Cambodian Refugees
    Grant Marshall; Fiscal Year: 2013
    ..Separate analyses will be directed at quantifying both parental and child service utilization, perceived need, and barriers. ..
  12. Comparing ankle arthrodesis to ankle arthroplasty
    Bruce Sangeorzan; Fiscal Year: 2012
    ..is established that some potential subjects (we estimate 50% based on pilot data) will not want to undergo random allocation where blinding is not possible and one treatment represents relatively new technology;crossover after ..
  13. Cherokee Nation Prevention Trial: Interactive Effects of Environment &SBIRT
    KELLI ANN KOMRO; Fiscal Year: 2013
    ..S. continues to struggle with significant alcohol-related risks and consequences among youth. The proposed project will provide a rigorous evaluation of a new, integrated community-level preventive intervention. ..
  14. Kin and Community Support for Orphans in Cambodia
    PATRICK C HEUVELINE; Fiscal Year: 2011
    ....
  15. Silent Cerebral Infarct Multi-Center Clinical Trial -SCC
    Bruce Barton; Fiscal Year: 2009
    ..sec., and will not be eligible for the study. The remaining 338 children will be eligible for random allocation to either observation or blood transfusion therapy...
  16. Predictors of Hospital-Acquired Urinary Tract-Related Bloodstream Infection in VA
    Sanjay K Saint; Fiscal Year: 2013
    ..abstract_text> ..
  17. Silent Cerebral Infarct Multi-Center Clinical Trial
    MICHAEL RUTLEDGE DEBAUN; Fiscal Year: 2010
    ..sec. and will not be eligible for the study. The remaining 338 children will be eligible for random allocation to either observation or blood transfusion therapy...
  18. How do Changes in Families'Health Insurance Affect Children's Healthcare?
    Jennifer E DeVoe; Fiscal Year: 2013
    ..This project provides an unprecedented opportunity to study past changes, to establish a current baseline prior to the implementation of future health policy reforms, and then to evaluate the real-time impact of these changes. ..
  19. Rand Center of Excellence for the Study of Appropriateness of Care in CAM
    IAN DOUGLASS COULTER; Fiscal Year: 2013
    ..From these data are abstracted about the treatment given for CCP and the number of times M/M is done for CCP is obtained. We will also interview a sample of patients attending the clinics and do a follow study for their outcomes. ..
  20. HIV-1 Evolution and Functional Correlates of MTCT
    KATHERINE F LUZURIAGA; Fiscal Year: 2013
    ..g., through passive or active immunization) or targeting other Env functional properties (tropism, infectivity) hold promise to block primary infection of women and children. ..
  21. Causal Inference in Repeated Observational Studies
    Bo Lu; Fiscal Year: 2012
    ..Frequently, random allocation of participants to treatments is not feasible due to practical and ethical reasons...
  22. Pregnancy Risk Assessment Monitoring System (PRAMS) (U01) Category B. (Existing S
    Riley Peters; Fiscal Year: 2013
    ..2) The Washington State PRAMS project will continue to analyze PRAMS data. 3) The Washington State PRAMS project will utilize PRAMS data to affect policy development. ..
  23. Role of MHC molecules in NK recognition
    David H Raulet; Fiscal Year: 2010
    ..abstract_text> ..
  24. PARENTAL EMPLOYMENT AND CHILD DEVELOPMENT
    CHRISTOPHER RUHM; Fiscal Year: 2002
    ..This project will also improve on earlier research by examining a wider set of child outcomes and considering the effects of paternal employment. ..
  25. Modeling HIV-1 primary transmission in vitro and in vivo
    Donald E Mosier; Fiscal Year: 2013
    ..This information is essential for designing strategies to prevent transmission. ..
  26. Predictors of Hospital-Acquired Urinary Tract-Related Bloodstream Infection
    Sanjay Saint; Fiscal Year: 2009
    ....
  27. BLADDER CANCER CASE CONTROL STUDY OF ARSENIC IN WATER
    ALLAN SMITH; Fiscal Year: 2000
    ....
  28. Constructing Recommender Systems for Effective Health Messages: Smoking Cessation
    JOSEPH NICHOLAS CAPPELLA; Fiscal Year: 2013
    ..those receiving a random selection or a "most preferred" set. ..
  29. RANDOMIZED TRIAL OF THE BRIEF NEGOTIATED INTERVIEW
    Edward Bernstein; Fiscal Year: 2002
    ..After random allocation, a control group of 800 will receive the standard of care only (written advice/referral to treatment) and an ..
  30. RISK FACTORS FOR VIOLENCE AMONG NURSES
    SUSAN GERBERICH; Fiscal Year: 2000
    ..This study design will enable us to calculate rate ratios for the effect of exposures of interest on the rate of injury. From this effort, specific prevention and control strategies can be developed more realistically. ..
  31. RISK FACTORS FOR INTRACRANIAL MENINGIOMA
    Wt Longstreth; Fiscal Year: 1999
    ..The long-term goal of this study is to reduce the incidence of meningioma by identifying its etiologic risk factors. ..
  32. FETAL COCAINE EXPOSURE; EFFECT ON NEONATAL BREATHING
    GEORGE OLSEN; Fiscal Year: 1991
    ..Assignment of treatments will be random allocation. Breathing will be assessed by a noninvasive plethysmographic method in conscious neonatal animals who have ..
  33. BLACK-WHITE DIFFERENCES IN THE USE OF LONG-TERM CARE
    Raynard Kington; Fiscal Year: 1993
    ..Statistical techniques will correct for the competing risks of death and nursing home admission and the non-random selection of parents who become significantly impaired...
  34. MANAGED CARE & QUALITY: CHILDREN WITH CHRONIC CONDITIONS
    Frederick Connell; Fiscal Year: 2001
    ..abstract_text> ..
  35. Outcomes of Preschool Mental Health Problems
    Adrian Angold; Fiscal Year: 2009
    ..g., from depressive to conduct symptoms - heterotypie continuity). ..
  36. COMMUNITY BASED ENVIRONMENTAL HEALTH INTERVENTION
    Leslie Clarke; Fiscal Year: 2000
    ..b>Random allocation to treatment and control groups will be based on work group membership...
  37. Secondary drug prevention of stroke in long-term care
    Brian Quilliam; Fiscal Year: 2000
    ..Yet, confounding introduced by non-random allocation to drug treatment, defining of exposures when treatment may vary through time and bias introduced with ..
  38. Is Childhood Obesity Related to Participation in School Meals?
    SUZANNE BAXTER; Fiscal Year: 2009
    ....
  39. Scientific Misconduct: Role of the Research Coordinator
    Barbara Habermann; Fiscal Year: 2004
    ....
  40. ADDRESSING HIV RISK AND HEALTH CARE NEEDS UNDER HMO
    Rafaela Robles; Fiscal Year: 2000
    ..For each of the stated outcomes a cost will be estimated. The total cost of resources use will be estimated using claims data from managed care organizations providing services in the area. ..
  41. ISCHEMIC NECROSIS OF BONE: CLINICAL-LABORATORY STUDY
    DAVID HUNGERFORD; Fiscal Year: 1980
    ..The affect of core decompression on modifying changes in bone blood flow is also being assessed...
  42. EXERCISE EFFECT ON FUNCTION OF RESIDENTS WITH AD
    Ruth Tappen; Fiscal Year: 2000
    ..A low cost intervention such as the one proposed that reduces excess disability and maintains residents at their highest possible level of function would not only increase their quality of life but also reduce the cost of their care. ..
  43. Health Services for Parasuicidal Behavior
    KATHERINE COMTOIS; Fiscal Year: 2005
    ..3) Identify service utilization patterns related to system factors above and beyond patient factors (e.g., crisis services replacing outpatient as primary treatment for parasuicidal individuals). ..
  44. COLORECTAL CANCER TRANSFER FACTOR FEASIBILITY STUDY
    ROBERT YONEMOTO; Fiscal Year: 1980
    ..Pre- and postoperative serial LAI-blocking assays will be correlated with stage of disease, tumor burden and CEA. LAI-blocking assay may serve as a prognosticator and an adjunct to treatment of colorectal carcinoma...
  45. Gis, multilevel modeling and breast cancer screening
    Mario Schootman; Fiscal Year: 2002
    ..Few studies focusing on breast cancer screening have taken this approach, which we, and others feel is warranted. ..
  46. Mississippi Youth Tobacco Survey
    Robert McMillen; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  47. OLIGONUCLEOTIDES THAT BIND SLE ANTI-DNA ANTIBODIES
    Gary Beaudry; Fiscal Year: 1993
    ..Ultimately, determinants that are widely recognized by patient IgGs will be used as lead compounds to design drugs that block formation of damaging immune complexes and inhibit production of pathogenic antibodies in SLE patients...
  48. Archiving the Charleston Heart Study
    Paul Nietert; Fiscal Year: 2002
    ..abstract_text> ..
  49. THE IMPACT OF CLINICAL PATHWAYS FOR REHABILITATION CARE
    Deborah Dobrez; Fiscal Year: 1999
    ..How patients are selected to be on a pathway will also be examined in order to measure and control for the bias introduced by the non-random selection. ..
  50. Preventing Work Injuries and Chronic Illnesses in Truckers
    KURT HEGMANN; Fiscal Year: 2009
    ..WHEEL will be pilot-tested on 35 truck drivers for acceptance and to determine effect size for design of a full intervention. ..
  51. PARTICLE PROGRAM--CLINICAL TRIALS
    Simon Kramer; Fiscal Year: 1980
    ..neutron facilities, one pi-meson facility and one heavy ion facility who are in the process of initiating random allocation clinical studies...
  52. OT OUTCOMES: CHILDREN WITH SENSORY MODULATION DISORDERS
    Lucy Miller; Fiscal Year: 2001
    ..If SMD inclusion criteria are met, child is assigned to one of three groups using blocked, random allocation: immediate treatment, wait-list condition, or alternative treatment...
  53. THROMBOTIC, INFLAMMATORY & GENE MARKERS OF CVD IN WOMEN
    Paul Ridker; Fiscal Year: 2002
    ....
  54. SECONDARY PREVENTION TRIAL OF VENOUS THROMBOSIS
    Paul Ridker; Fiscal Year: 2002
    ....
  55. Modular Chimeric Vaccines tailored for malaria parasites
    Alberto Moreno; Fiscal Year: 2010
    ..The emergence of P. vivax chloroquine and primaquine drug resistant strains has brought increased emphasis to the need for alternative prophylactic and therapeutic strategies to control this infection. ..
  56. ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICS
    RICHARD ZAGER; Fiscal Year: 2001
    ....
  57. EPIDEMIOLOGY OF FOOT & ANKLE DISORDERS AMONG THE ELDERLY
    John McKinlay; Fiscal Year: 2001
    ..Data will be gathered from a population-based multi-ethnic sample (N=1524) of older persons in a large northeastern city, and will be collected during an in-home interview and examination. ..
  58. Causal Effects of Schooling on Adult and Child Health
    JERE BEHRMAN; Fiscal Year: 2005
    ..abstract_text> ..
  59. Medication Use, Comorbidity and Outcomes in Aging populations
    Robert Glynn; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  60. Hormones and Erectile Dysfunction in Aging Men
    John McKinlay; Fiscal Year: 2004
    ....
  61. Biology and Drug Resistance of Candida Biofilms
    Mahmoud Ghannoum; Fiscal Year: 2005
    ..albicans biofilms. By studying biofilm model systems and applying this knowledge to the patient population, we will gain a wealth of data about the biology and drug resistance of C. albicans in biofilms. ..
  62. SECONDARY PREVENTION TRIAL OF VENOUS THROMBOSIS-DCC
    Robert Glynn; Fiscal Year: 2002
    ..Events will be assessed by yearly visits and bi-monthly questionnaires at the time of the INR monitoring. ..