feasibility studies

Summary

Summary: Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.

Top Publications

  1. pmc The feasibility of using pedometers and brief advice to increase activity in sedentary older women--a pilot study
    Jacqui A Sugden
    Section of Ageing and Health, Division of Medicine and Therapeutics, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
    BMC Health Serv Res 8:169. 2008
  2. pmc Development and assessment of the Alberta Context Tool
    Carole A Estabrooks
    Faculty of Nursing, University of Alberta, Alberta, Canada
    BMC Health Serv Res 9:234. 2009
  3. pmc What is a pilot or feasibility study? A review of current practice and editorial policy
    Mubashir Arain
    Health Services Research, ScHARR, University of Sheffield, Regent Court, Regent St, Sheffield S1 4DA, UK
    BMC Med Res Methodol 10:67. 2010
  4. ncbi The PedsQL 4.0 as a pediatric population health measure: feasibility, reliability, and validity
    James W Varni
    Department of Landscape Architecture and Urban Planning, College of Architecture and the Department of Pediatrics, Texas A and M University, College Station, TX 77843, USA
    Ambul Pediatr 3:329-41. 2003
  5. ncbi Flexible transgastric peritoneoscopy: a novel approach to diagnostic and therapeutic interventions in the peritoneal cavity
    Anthony N Kalloo
    Division of Gastroenterology, Johns Hopkins Hospital, Baltimore, Maryland 21205, USA
    Gastrointest Endosc 60:114-7. 2004
  6. pmc Challenges of internet recruitment: a case study with disappointing results
    Malcolm Koo
    Department of Public Health Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    J Med Internet Res 7:e6. 2005
  7. ncbi Feasibility of reducing older adults' sedentary time
    Paul A Gardiner
    University of Queensland, Cancer Prevention Research Centre, School of Population Health, Brisbane, Australia
    Am J Prev Med 41:174-7. 2011
  8. ncbi Feasibility, acceptability and cost of home-based HIV testing in rural Kenya
    Joel Negin
    School of Public Health, University of Sydney, Sydney, Australia
    Trop Med Int Health 14:849-55. 2009
  9. pmc How we design feasibility studies
    Deborah J Bowen
    School of Public Health, Boston University, Boston, Massachusetts 02118, USA
    Am J Prev Med 36:452-7. 2009
  10. ncbi The cost diary: a method to measure direct and indirect costs in cost-effectiveness research
    M E Goossens
    Institute for Rehabilitation Research, Hoensbroek, The Netherlands
    J Clin Epidemiol 53:688-95. 2000

Detail Information

Publications387 found, 100 shown here

  1. pmc The feasibility of using pedometers and brief advice to increase activity in sedentary older women--a pilot study
    Jacqui A Sugden
    Section of Ageing and Health, Division of Medicine and Therapeutics, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
    BMC Health Serv Res 8:169. 2008
    ..The aim of this pilot study was to evaluate the feasibility of the use of pedometers plus a theory-based intervention to assist sedentary older women to accumulate increasing amounts of physical activity, mainly through walking...
  2. pmc Development and assessment of the Alberta Context Tool
    Carole A Estabrooks
    Faculty of Nursing, University of Alberta, Alberta, Canada
    BMC Health Serv Res 9:234. 2009
    ..This paper presents the development and initial psychometric validation of the Alberta Context Tool (ACT), an eight dimension measure of organizational context for healthcare settings...
  3. pmc What is a pilot or feasibility study? A review of current practice and editorial policy
    Mubashir Arain
    Health Services Research, ScHARR, University of Sheffield, Regent Court, Regent St, Sheffield S1 4DA, UK
    BMC Med Res Methodol 10:67. 2010
    ..We extended this survey to grant-awarding bodies and editors of medical journals to discover their policies regarding the function and reporting of pilot studies...
  4. ncbi The PedsQL 4.0 as a pediatric population health measure: feasibility, reliability, and validity
    James W Varni
    Department of Landscape Architecture and Urban Planning, College of Architecture and the Department of Pediatrics, Texas A and M University, College Station, TX 77843, USA
    Ambul Pediatr 3:329-41. 2003
    ....
  5. ncbi Flexible transgastric peritoneoscopy: a novel approach to diagnostic and therapeutic interventions in the peritoneal cavity
    Anthony N Kalloo
    Division of Gastroenterology, Johns Hopkins Hospital, Baltimore, Maryland 21205, USA
    Gastrointest Endosc 60:114-7. 2004
    ..A novel endoscopic peroral transgastric approach to the peritoneal cavity was tested in a porcine model in acute and long-term survival experiments...
  6. pmc Challenges of internet recruitment: a case study with disappointing results
    Malcolm Koo
    Department of Public Health Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    J Med Internet Res 7:e6. 2005
    ..This paper summarizes our experiences from 2 studies in which we attempted to recruit teenagers on the Internet for a questionnaire study to evaluate a smoking-cessation website...
  7. ncbi Feasibility of reducing older adults' sedentary time
    Paul A Gardiner
    University of Queensland, Cancer Prevention Research Centre, School of Population Health, Brisbane, Australia
    Am J Prev Med 41:174-7. 2011
    ..Sedentary time (too much sitting, as distinct from lack of exercise) is a prevalent risk to health among older adults...
  8. ncbi Feasibility, acceptability and cost of home-based HIV testing in rural Kenya
    Joel Negin
    School of Public Health, University of Sydney, Sydney, Australia
    Trop Med Int Health 14:849-55. 2009
    ..To demonstrate the feasibility, acceptability and cost of home-based HIV testing and to examine the applicability of the model to high HIV prevalence settings...
  9. pmc How we design feasibility studies
    Deborah J Bowen
    School of Public Health, Boston University, Boston, Massachusetts 02118, USA
    Am J Prev Med 36:452-7. 2009
    ..This article describes the diverse types of feasibility studies conducted in the field of cancer prevention, using a group of recently funded grants from the National ..
  10. ncbi The cost diary: a method to measure direct and indirect costs in cost-effectiveness research
    M E Goossens
    Institute for Rehabilitation Research, Hoensbroek, The Netherlands
    J Clin Epidemiol 53:688-95. 2000
    ..However, for physiotherapy contacts there were differences between the self-reported and insurance data. This study shows how the cost diary might be used successfully in cost-effectiveness studies...
  11. pmc Online advertising as a public health and recruitment tool: comparison of different media campaigns to increase demand for smoking cessation interventions
    Amanda L Graham
    The Schroeder Institute for Tobacco Research and Policy Studies, American Legacy Foundation, NW, Washington, DC 20036, USA
    J Med Internet Res 10:e50. 2008
    ..Online ads can be implemented in many forms, and surveys consistently show that consumers are receptive. Few studies have examined the potential of online advertising to recruit smokers to cessation treatments...
  12. ncbi The SHED-IT randomized controlled trial: evaluation of an Internet-based weight-loss program for men
    Philip J Morgan
    School of Education, Faculty of Education and Arts, University of Newcastle, Callaghan, New South Wales, Australia
    Obesity (Silver Spring) 17:2025-32. 2009
    ..The Internet is a feasible and effective medium for weight loss in men but strategies need to be explored to improve engagement in online programs...
  13. ncbi Material differentiation by dual energy CT: initial experience
    Thorsten R C Johnson
    Department of Clinical Radiology, University of Munich Grosshadern Campus, Marchioninistrasse 15, 81377 Munich, Germany
    Eur Radiol 17:1510-7. 2007
    ..Dual energy CT offers a more specific tissue characterization in CT and can improve the assessment of vascular disease. Further studies are required to draw conclusions on the diagnostic value of the individual applications...
  14. ncbi Preparation of a promising angiogenesis PET imaging agent: 68Ga-labeled c(RGDyK)-isothiocyanatobenzyl-1,4,7-triazacyclononane-1,4,7-triacetic acid and feasibility studies in mice
    Jae Min Jeong
    Department of Nuclear Medicine, Cancer Research Institute College of Medicine, Seoul National University, Jongro Gu, Seoul, Korea
    J Nucl Med 49:830-6. 2008
    ..The labeled RGD so produced was subjected to an in vitro binding assay and in vivo biodistribution and PET studies...
  15. pmc Multimodal e-mental health treatment for depression: a feasibility trial
    David C Mohr
    Department of Preventive Medicine, Northwestern University, Chicago, United States
    J Med Internet Res 12:e48. 2010
    ..The intervention required frequent brief log-ins for self-monitoring and feedback as well as email and brief telephone support guided by a theory-driven manualized protocol...
  16. ncbi Feasibility of low-dose coronary CT angiography: first experience with prospective ECG-gating
    Lars Husmann
    Department of Medical Radiology and Cardiovascular Center, University Hospital Zurich, Raemistr 100, CH 8091 Zurich, Switzerland
    Eur Heart J 29:191-7. 2008
    ..To determine the feasibility of prospective electrocardiogram (ECG)-gating to achieve low-dose computed tomography coronary angiography (CTCA)...
  17. pmc Feasibility of collecting diary data from asthma patients through mobile phones and SMS (short message service): response rate analysis and focus group evaluation from a pilot study
    Jacob Anhøj
    H S Unit for Patient Safety, Hvidovre, Denmark
    J Med Internet Res 6:e42. 2004
    ..The Internet has been suggested as a tool for the monitoring and self-management of asthma. However, in a recent study we found that a Web interface had some disadvantages and that users stopped using the application after a short while...
  18. ncbi Pedometer-driven walking for chronic low back pain: a feasibility randomized controlled trial
    Suzanne M McDonough
    Centre for Health and Rehabilitation Technologies, University of Ulster, Newtownabbey, County Antrim, UK School of Psychology, University of Ulster, Londonderry, Co Londonderry, UK UKCRC Centre of Excellence for Public Health NI, Queens University Belfast, UK Frontier Science Scotland, Kingussie, UK School of Health and Rehabilitation Science, University of Pittsburgh, Pittsburgh, PA Walking Behavior Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA Centre for Physiotherapy Research, University of Otago, North Dunedin, New Zealand School of Public Health, Physiotherapy and Population Science, University College Dublin, Dublin, Ireland
    Clin J Pain 29:972-81. 2013
    ..To evaluate the feasibility of an RCT of a pedometer-driven walking program and education/advice to remain active compared with education/advice only for treatment of chronic low back pain (CLBP)...
  19. ncbi User acceptability and feasibility of self-testing with HIV rapid tests
    Vernon J Lee
    Department of Clinical Epidemiology, Communicable Disease Centre, Tan Tock Seng Hospital, 802 Moulmein Road, Singapore
    J Acquir Immune Defic Syndr 45:449-53. 2007
    ..Because HIV rapid tests are considered for self-testing, this study aims to determine the user acceptability and feasibility of self-testing...
  20. ncbi Successful participant recruitment strategies for an online smokeless tobacco cessation program
    Judith S Gordon
    Oregon Research Institute, 1715 Franklin Blvd, Eugene, OR 97403, USA
    Nicotine Tob Res 8:S35-41. 2006
    ..The use of thematic mailings is novel in research settings. Recruitment of study participants went quickly and smoothly. Google ads and mailings to media outlets were the methods that recruited the highest number of participants...
  21. ncbi Use of data linkage to investigate the aetiology of acute lower respiratory infection hospitalisations in children
    Hannah C Moore
    Telethon Institute for Child Health Research, Centre for Child Health Research, Schools of Pathology and Laboratory Medicine, University of Western Australia, Perth, Western Australia, Australia
    J Paediatr Child Health 48:520-8. 2012
    ..To document the aetiology of acute lower respiratory infection (ALRI) hospitalisations in Western Australian children by linking population-based laboratory data with hospital morbidity data...
  22. ncbi Short message service (SMS) technology in alcohol research--a feasibility study
    Emmanuel Kuntsche
    Swiss Institute for the Prevention of Alcohol and Drug Problems SIPA, Research Department, PO Box 870, CH1001 Lausanne, Switzerland
    Alcohol Alcohol 44:423-8. 2009
    ..e. prior to a possible drinking event) changed the respondents' assessment, made on the following day, of the number of drinks consumed...
  23. pmc Subject-specific myoelectric pattern classification of functional hand movements for stroke survivors
    Sang Wook Lee
    Sensory Motor Performance Program, Rehabilitation Institute of Chicago, IL 60616, USA
    IEEE Trans Neural Syst Rehabil Eng 19:558-66. 2011
    ....
  24. ncbi Total mesorectal excision for middle and lower rectal cancer: a single institution experience with 337 consecutive patients
    Pompiliu Piso
    Department for Visceral and Transplantation Surgery, Hannover Medical School, Germany
    J Surg Oncol 86:115-21. 2004
    ..There have been reports on improved prognosis after TME for middle and lower rectal cancer. No prospective randomized studies have yet been performed. This is a large single institution series evaluating its own results of TME...
  25. ncbi Localization of the surgical bed using supine magnetic resonance and computed tomography scan fusion for planification of breast interstitial brachytherapy
    Marjory Jolicoeur
    Department of Radiotherapy, Hopital Charles LeMoyne, University of Sherbrooke, Quebec, Canada
    Radiother Oncol 100:480-4. 2011
    ..To assess the inter-observer variability of surgical bed delineation on computed tomography (CT) and supine MR...
  26. ncbi 3D Dosimetric verification of volumetric-modulated arc therapy by portal dosimetry
    Anton Mans
    Department of Radiation Oncology, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Radiother Oncol 94:181-7. 2010
    ..To demonstrate the feasibility of back-projection portal dosimetry for accurate 3D dosimetric verification of volumetric-modulated arc therapy (VMAT), pre-treatment as well as in vivo...
  27. ncbi Recruitment of research participants through the Internet
    Eun Ok Im
    School of Nursing, University of Texas at Austin, Austin, TX 78701, USA
    Comput Inform Nurs 22:289-97. 2004
    ....
  28. pmc Feasibility and reliability of point-of-care pocket-sized echocardiography
    Garrett Newton Andersen
    Levanger Hospital, Nord Trøndelag Health Trust, Levanger, Norway
    Eur J Echocardiogr 12:665-70. 2011
    ..To study the reliability and feasibility of point-of-care pocket-sized echocardiography (POCKET) at the bedside in patients admitted to a medical department at a non-university hospital...
  29. pmc Can high-field MREIT be used to directly detect neural activity? Theoretical considerations
    R J Sadleir
    J Crayton Pruitt Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611 6131, USA
    Neuroimage 52:205-16. 2010
    ..We also propose the idea of using MREIT as an alternative means of studying neuromodulation...
  30. pmc Effect of a multimodal high intensity exercise intervention in cancer patients undergoing chemotherapy: randomised controlled trial
    Lis Adamsen
    Institute of Public Health, University of Copenhagen, Copenhagen, Denmark
    BMJ 339:b3410. 2009
    ....
  31. ncbi Ecological momentary assessment in alcohol, tobacco, cannabis and opiate dependence: a comparison of feasibility and validity
    Fuschia Serre
    Laboratoire de psychiatrie SANPSY, CNRS USR 3413, Univ Bordeaux, Bordeaux, France
    Drug Alcohol Depend 126:118-23. 2012
    ..This study compares the feasibility and validity of computerized ambulatory monitoring in outpatients seeking treatment for alcohol, tobacco, cannabis or opiate dependence...
  32. ncbi Survival and surgical outcomes after laparoscopy-assisted total gastrectomy for gastric cancer: case-control study
    Bang Wool Eom
    Gastric Cancer Branch, Research Institute and Hospital, National Cancer Center, Ilsan ro 323, Ilsandong gu, Goyang si, Gyeonggi Do, 411 769, South Korea
    Surg Endosc 26:3273-81. 2012
    ..Few results regarding the long-term survival from laparoscopy-assisted total gastrectomy (LATG) have been reported. The purpose of this study was to investigate the feasibility of LATG in terms of long-term survival and morbidity...
  33. ncbi Intracranial metastatic disease spares the limbic circuit: a review of 697 metastatic lesions in 107 patients
    James C Marsh
    Department of Radiation Oncology, Rush University Medical Center, Chicago, Illinois, USA
    Int J Radiat Oncol Biol Phys 76:504-12. 2010
    ..This review was performed to assess the feasibility of selectively sparing the limbic system during whole-brain radiotherapy and prophylactic cranial irradiation...
  34. ncbi Quantitative computed tomography liver perfusion imaging using dynamic spiral scanning with variable pitch: feasibility and initial results in patients with cancer metastases
    Robert Goetti
    Institute of Diagnostic Radiology, University Hospital Zurich, Zurich, Switzerland
    Invest Radiol 45:419-26. 2010
    ....
  35. ncbi Caution regarding the use of pilot studies to guide power calculations for study proposals
    Helena Chmura Kraemer
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif 94305, USA
    Arch Gen Psychiatry 63:484-9. 2006
    ..The argument herein is not meant to discourage clinical researchers from performing pilot studies (or review committees from requiring them) but simply to caution against their use for the objective of guiding power calculations...
  36. pmc Surgical outcome after docetaxel-based neoadjuvant chemotherapy in locally-advanced gastric cancer
    Roberto Biffi
    Division of Abdomino Pelvic Surgery, European Institute of Oncology, Via Ripamonti 435, I 20141 Milan, Italy
    World J Gastroenterol 16:868-74. 2010
    ..To investigate feasibility, morbidity and surgical mortality of a docetaxel-based chemotherapy regimen randomly administered before or after gastrectomy in patients suffering from locally-advanced resectable gastric cancer...
  37. ncbi Adipose-derived cells
    Emanuele Meliga
    Thoraxcenter, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
    Cell Transplant 16:963-70. 2007
    ....
  38. ncbi Helical tomotherapy with simultaneous integrated boost after laparoscopic staging in patients with cervical cancer: analysis of feasibility and early toxicity
    Simone Marnitz
    Department of Radiooncology, Charite University Medicine, Berlin, Germany
    Int J Radiat Oncol Biol Phys 82:e137-43. 2012
    ..To demonstrate the feasibility and safety of the simultaneous integrated boost technique for dose escalation in combination with helical tomotherapy in patients with cervical cancer...
  39. pmc Patient study of in vivo verification of beam delivery and range, using positron emission tomography and computed tomography imaging after proton therapy
    Katia Parodi
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 68:920-34. 2007
    ..To investigate the feasibility and value of positron emission tomography and computed tomography (PET/CT) for treatment verification after proton radiotherapy...
  40. ncbi Sparing of the hippocampus, limbic circuit and neural stem cell compartment during partial brain radiotherapy for glioma: a dosimetric feasibility study
    James C Marsh
    Department of Radiation Oncology, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Med Imaging Radiat Oncol 55:442-9. 2011
    ..The aim of this study was to assess the feasibility of sparing contralateral or bilateral neural stem cell (NSC) compartment, hippocampus and limbic circuit during partial brain radiotherapy (PBRT)...
  41. ncbi Accuracy and reproducibility of real-time three-dimensional echocardiography for assessment of right ventricular volumes and ejection fraction in children
    Xiuzhang Lu
    Baylor College of Medicine and Texas Children s Hospital, Houston, Texas 77030, USA
    J Am Soc Echocardiogr 21:84-9. 2008
    ..Measurement of right ventricular (RV) volumes and ejection fraction (EF) by two-dimensional echocardiography has limited accuracy and reproducibility because of the complex RV geometry...
  42. ncbi Sparing of the neural stem cell compartment during whole-brain radiation therapy: a dosimetric study using helical tomotherapy
    James C Marsh
    Department of Radiation Oncology, Rush University Medical Center, Chicago, Illinois 60612, USA
    Int J Radiat Oncol Biol Phys 78:946-54. 2010
    ..To assess the feasibility of dosimetrically sparing the hippocampus and neural stem cell (NSC) compartment during whole-brain radiotherapy (WBRT) and prophylactic cranial irradiation (PCI)...
  43. ncbi Development and implementation of a standardized precompetition medical assessment of international elite football players--2006 FIFA World Cup Germany
    Jiri Dvorak
    FIFA Medical Assessment and Research Centre F MARC, Zurich, Switzerland
    Clin J Sport Med 19:316-21. 2009
    ....
  44. pmc Feasibility and validity of computerized ecological momentary assessment in schizophrenia
    Eric Granholm
    Psychology Service, VA San Diego Healthcare System 116B, San Diego, CA 92161, USA
    Schizophr Bull 34:507-14. 2008
    ..The present investigation examined the feasibility and validity of this assessment methodology in outpatients with schizophrenia...
  45. ncbi MINI International Neuropsychiatric Schedule: clinical utility and patient acceptance
    Narsimha R Pinninti
    SOM UMDNJ, 2250 Chapel Avenue West, Cherry Hill, NJ 08002, USA
    Eur Psychiatry 18:361-4. 2003
    ..Mini International Neuropsychiatric Schedule is a short diagnostic instrument validated against SCID and CIDI but its feasibility and patient acceptance has not been studied...
  46. ncbi Technical and organisational feasibility of a multifunctional telemedicine system in an emergency medical service - an observational study
    Sebastian Bergrath
    Emergency Medical Care Section, Department of Anaesthesiology, University Hospital Aachen, RWTH Aachen University, Pauwelsstrasse 30, D 52074 Aachen, Germany
    J Telemed Telecare 17:371-7. 2011
    ..Use of the telemedical system in EMS is feasible and the quality of the transmitted images and video was satisfactory. However, technical reliability and availability need to be improved prior to routine use...
  47. ncbi Cell tagging with clinically approved iron oxides: feasibility and effect of lipofection, particle size, and surface coating on labeling efficiency
    Lars Matuszewski
    Department of Clinical Radiology, University Hospital Muenster, Albert Schweitzer Strasse 33, D 48129 Muenster, Germany
    Radiology 235:155-61. 2005
    ..To evaluate the effect of lipofection, particle size, and surface coating on labeling efficiency of mammalian cells with superparamagnetic iron oxides (SPIOs)...
  48. ncbi Feasibility and tolerability of transnasal/per-oral placement of the wireless pH capsule vs. traditional 24-h oesophageal pH monitoring--a randomized trial
    W M Wong
    The Neuro Enteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, AZ 85723, USA
    Aliment Pharmacol Ther 21:155-63. 2005
    ..The wireless pH is a new technique to monitor oesophageal acid exposure...
  49. ncbi Feasibility of identifying pancreatic cancer based on serum metabolomics
    Oliver F Bathe
    Department of Surgery, University of Calgary, Calgary, Alberta, Canada
    Cancer Epidemiol Biomarkers Prev 20:140-7. 2011
    ..We postulated that the abundance of various metabolites in blood would facilitate the diagnosis of pancreatic and biliary lesions, which could potentially prevent unnecessary surgery...
  50. ncbi Transthoracic echocardiography for cardiopulmonary monitoring in intensive care
    M B Jensen
    Aarhus University Hospital, Department of Anaesthesiology and Intensive Care, Skejby Sygehus, Denmark
    Eur J Anaesthesiol 21:700-7. 2004
    ..To evaluate the feasibility of an abbreviated focus assessed transthoracic echocardiographic protocol, consisting of four standardized acoustic views for cardiopulmonary screening and monitoring...
  51. ncbi Feasibility of using an implantable system to measure thoracic congestion in an ambulatory chronic heart failure canine model
    Li Wang
    Medtronic, Inc, Minneapolis, Minnesota 55432, USA
    Pacing Clin Electrophysiol 28:404-11. 2005
    ..Noninvasive measures of impedance reflect alterations in thoracic fluid and pulmonary edema in acute animal and human studies...
  52. ncbi Laparoendoscopic single-site (LESS) surgery in patients with benign adnexal disease
    Pedro F Escobar
    Department of OB GYN and Women s Health Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Fertil Steril 93:2074.e7-10. 2010
    ..To present our initial experience in laparoscopic surgery for benign adnexal disease performed exclusively through an umbilical incision using a single three-channel port and flexible laparoscopic instrumentation...
  53. ncbi Quantitative hyperemic reactivity in opposed limbs during myocardial perfusion imaging: a new marker of coronary artery disease
    Jocelyn Dupuis
    Department of Medicine, Montreal Heart Institute, Montreal, Quebec, Canada
    J Am Coll Cardiol 44:1473-7. 2004
    ..We sought to evaluate the feasibility and validity of a new method to quantify the hyperemic response of the forearms that can be incorporated into a rest myocardial perfusion protocol...
  54. ncbi Out-of-hospital airway management by paramedics and emergency physicians using laryngeal tubes
    Richard Schalk
    Clinic of Anaesthesiology, Intensive Care Medicine, and Pain Therapy, J W Goethe University Hospital Frankfurt, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Resuscitation 81:323-6. 2010
    ..We prospectively evaluated the feasibility of laryngeal tubes used by paramedics and emergency physicians for out-of-hospital airway management...
  55. ncbi A critical comparison of echocardiographic measurements used for optimizing cardiac resynchronization therapy: stroke distance is best
    Dewi E Thomas
    Wales Heart Research Institute, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Eur J Heart Fail 11:779-88. 2009
    ..We also assessed the utility of 'stroke distance' [left ventricular outflow tract velocity-time integral (LVOT VTI)] in performing this function...
  56. ncbi Transgastric cholecystectomy: transgastric accessibility to the gallbladder improved with the SEMF method and a novel multibending therapeutic endoscope
    Kazuki Sumiyama
    Developmental Endoscopy Unit, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Gastrointest Endosc 65:1028-34. 2007
    ..Transgastric cholecystectomy is thought to technically and anatomically challenge a single entry flexible endoscopic approach...
  57. pmc 'Ready. Set. ACTION!' A theater-based obesity prevention program for children: a feasibility study
    Dianne Neumark-Sztainer
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 South Second Street, Suite 300, Minneapolis, MN 55454, USA
    Health Educ Res 24:407-20. 2009
    ..The next research step may be to incorporate theater-based programs into more comprehensive school-based interventions, with both educational and environmental components, and evaluate program impact...
  58. pmc Feasibility of including cellular telephone numbers in random digit dialing for epidemiologic case-control studies
    Lynda F Voigt
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer ResearchCenter, Seattle, Washington, USA
    Am J Epidemiol 173:118-26. 2011
    ....
  59. ncbi Feasiblity of transoral robotic hypopharyngectomy for early-stage hypopharyngeal carcinoma
    Young Min Park
    Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Republic of Korea
    Oral Oncol 46:597-602. 2010
    ..3days average. Decannulation was carried out within an average of 6.3days after surgery. Transoral robotic hypopharyngectomy was feasible and ontologically safe technique for the treatment of early hypopharyngeal cancer...
  60. ncbi Transoral robotic surgery for oropharyngeal squamous cell carcinoma: a prospective study of feasibility and functional outcomes
    Eric J Moore
    Department of Otorhinolaryngology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Laryngoscope 119:2156-64. 2009
    ..To investigate the feasibility of transoral robotic surgery as a method of surgical treatment of oropharyngeal squamous cell carcinoma...
  61. ncbi In vivo PET imaging and biodistribution of radiolabeled gold nanoshells in rats with tumor xenografts
    Huan Xie
    Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, 3100 Cleburn St, Houston, TX 77004, United States
    Int J Pharm 395:324-30. 2010
    ..Overall, PET images with (64)Cu had good resolution and therefore can be further applied to guide photothermal treatment of cancer...
  62. ncbi Integrated PET/CT for the assessment of coronary artery disease: a feasibility study
    Mehdi Namdar
    Nuclear Cardiology Section, Division of Cardiology, Cardiovascular Center NUK C 32, University Hospital, Raemistrasse 100, CH 8091 Zurich, Switzerland
    J Nucl Med 46:930-5. 2005
    ..We present, what is to our knowledge, the first clinical evaluation of integrated PET/CT for combined acquisition of coronary anatomy and perfusion...
  63. ncbi Molecular MRI of early thrombus formation using a bimodal alpha2-antiplasmin-based contrast agent
    Robbert Jan J H M Miserus
    Department of Radiology, Maastricht University Medical Centre, Maastricht, The Netherlands
    JACC Cardiovasc Imaging 2:987-96. 2009
    ..We aimed to investigate whether early thrombus formation can be visualized with in vivo magnetic resonance imaging (MRI) by the use of a novel bimodal alpha(2)-antiplasmin-based contrast agent (CA)...
  64. ncbi Acute and long-term outcomes of the novel side access (SLK-View) stent for bifurcation coronary lesions: a multicenter nonrandomized feasibility study
    Fumiaki Ikeno
    Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94304, USA
    Catheter Cardiovasc Interv 67:198-206. 2006
    ..To evaluate technical feasibility and procedural safety of SLK-View stent for treating bifurcation lesions...
  65. ncbi The Frontier stent registry: safety and feasibility of a novel dedicated stent for the treatment of bifurcation coronary artery lesions
    Thierry Lefevre
    Institut Hospitalier Jacques Cartier, Massy, France
    J Am Coll Cardiol 46:592-8. 2005
    ..Santa Clara, California), a novel dedicated device designed for permanent side branch (SB) access, stent delivery by simultaneous kissing balloon inflation, and optimal main branch (MB) and SB ostium scaffolding...
  66. ncbi Self-help strategies that are helpful for sub-threshold depression: a Delphi consensus study
    Amy J Morgan
    Orygen Youth Health Research Centre, Department of Psychiatry, University of Melbourne, Australia
    J Affect Disord 115:196-200. 2009
    ..Sub-threshold depressive symptoms cause substantial disability in the population and are often managed with self-help strategies. However, it is unclear which self-help strategies are likely to be helpful and should be encouraged...
  67. ncbi Prospective multicenter performance evaluation of the second-generation colon capsule compared with colonoscopy
    R Eliakim
    Department of Gastroenterology, Rambam Health Care Campus, Haifa, Israel
    Endoscopy 41:1026-31. 2009
    ..A second-generation capsule endoscopy system, using the PillCam Colon 2, was developed to increase sensitivity for colorectal polyp detection compared with the first-generation system. The performance of this new system is reported...
  68. ncbi Intrathoracic impedance monitoring in patients with heart failure: correlation with fluid status and feasibility of early warning preceding hospitalization
    Cheuk Man Yu
    Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong
    Circulation 112:841-8. 2005
    ....
  69. ncbi Diagnostic accuracy of 320-row multidetector computed tomography coronary angiography in the non-invasive evaluation of significant coronary artery disease
    Fleur R de Graaf
    Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Eur Heart J 31:1908-15. 2010
    ..The aim of the present study was to assess the diagnostic accuracy of 320-row CTA in patients with known or suspected CAD...
  70. ncbi The European Organization for Research and Treatment of Cancer breast cancer-specific quality-of-life questionnaire module: first results from a three-country field study
    M A Sprangers
    Netherlands Cancer Institute, Amsterdam, The Netherlands
    J Clin Oncol 14:2756-68. 1996
    ....
  71. ncbi Strain rate imaging for noninvasive functional quantification of the left atrium: comparative studies in controls and patients with atrial fibrillation
    Yoshie Inaba
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    J Am Soc Echocardiogr 18:729-36. 2005
    ..7 +/- 0.8 vs 2.9 +/- 0.9 s -1 ; P < .01). Based on our findings, we conclude that noninvasive quantification of LA function using SR imaging enables evaluation of LA dysfunction due to aging and LA dilatation...
  72. pmc The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test: post-test study with blinded outcome assessments
    Peter Connick
    Dept, of Clinical Neurosciences, University of Cambridge, UK
    Trials 12:62. 2011
    ..Illustrated by the MSCIMS trial protocol, we describe a novel methodology based on detailed assessment of the anterior visual pathway as a model of wider disease processes--the "sentinel lesion approach"...
  73. pmc Pilot study of a cell phone-based exercise persistence intervention post-rehabilitation for COPD
    Huong Q Nguyen
    University of Washington, Seattle, WA 98199, USA
    Int J Chron Obstruct Pulmon Dis 4:301-13. 2009
    ..To determine the feasibility and efficacy of a six-month, cell phone-based exercise persistence intervention for patients with chronic obstructive pulmonary disease (COPD) following pulmonary rehabilitation...
  74. pmc Feasibility and cost-effectiveness of treating multidrug-resistant tuberculosis: a cohort study in the Philippines
    Thelma E Tupasi
    Tropical Disease Foundation, Manila, Philippines
    PLoS Med 3:e352. 2006
    ..However, evidence regarding the feasibility, effectiveness, cost, and cost-effectiveness of DOTS-Plus is still limited...
  75. ncbi Hepatic intra-arterial injection of drug-eluting bead, irinotecan (DEBIRI) in unresectable colorectal liver metastases refractory to systemic chemotherapy: results of multi-institutional study
    Robert C G Martin
    Division of Surgical Oncology, University of Louisville School of Medicine, Louisville, KY, USA
    Ann Surg Oncol 18:192-8. 2011
    ..The aim of this study is to evaluate the efficacy of hepatic arterial sulfonate hydrogel microsphere (drug-eluting beads), irinotecan preloaded therapy (DEBIRI) in metastatic colorectal cancer refractory to systemic chemotherapy...
  76. ncbi Baby steps: pedometer-determined and self-reported leisure-time exercise behaviors of pregnant women
    Danielle Symons Downs
    Exercise Psychology Laboratory, The Pennsylvania State University, University Park, PA 16802, USA
    J Phys Act Health 6:63-72. 2009
    ..Therefore, 2 studies were conducted to determine the feasibility of pregnant women wearing pedometers and to examine women's self-reported and objectively measured PA behaviors...
  77. ncbi Advanced hepatic ablation technique for creating complete cell death: irreversible electroporation
    Edward W Lee
    Division of Interventional Radiology, Department of Radiology, Ronald Reagan Medical Center at UCLA, David Geffen School of Medicine at UCLA, 757 Westwood Plaza, Suite 2125, Los Angeles, CA 90095, USA
    Radiology 255:426-33. 2010
    ..To evaluate the effectiveness of irreversible electroporation (IRE) in hepatic tissue ablation and the radiologic-pathologic correlation of IRE-induced cell death...
  78. ncbi Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction: final one-year results of the TOPCARE-AMI Trial
    Volker Schachinger
    Department of Cardiology, Johann Wolfgang Goethe University Frankfurt, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    J Am Coll Cardiol 44:1690-9. 2004
    ....
  79. ncbi Coronary computed tomography angiography with a consistent dose below 1 mSv using prospectively electrocardiogram-triggered high-pitch spiral acquisition
    Stephan Achenbach
    Department of Cardiology, University of Erlangen, Ulmenweg 18, 91054 Erlangen, Germany
    Eur Heart J 31:340-6. 2010
    ..We evaluated the feasibility and image quality of a new scan mode for coronary computed tomography angiography (CTA) with an effective dose of less than 1 mSv...
  80. pmc Prevention of gestational diabetes: feasibility issues for an exercise intervention in obese pregnant women
    Leonie K Callaway
    Royal Brisbane Clinical School, Royal Brisbane and Women s Hospital, Brisbane, Australia
    Diabetes Care 33:1457-9. 2010
    ..To examine the feasibility of an individualized exercise program to prevent gestational diabetes mellitus (GDM) in obese pregnant women...
  81. ncbi Combining GPS, GIS, and accelerometry: methodological issues in the assessment of location and intensity of travel behaviors
    Melody Oliver
    Centre for Physical Activity and Nutrition Research, Auckland University of Technology, Auckland, New Zealand
    J Phys Act Health 7:102-8. 2010
    ..This study aimed to assess the feasibility of combining GPS, GIS, and accelerometry to understand transport-related physical activity (TPA) in adults...
  82. ncbi A feasibility and safety study of bronchoscopic thermal vapor ablation: a novel emphysema therapy
    Gregory I Snell
    Alfred Hospital and Monash University, Melbourne, NSW 3004, Australia
    Ann Thorac Surg 88:1993-8. 2009
    ..This study reports the feasibility and safety of novel second-generation bronchoscopic lung volume reduction (LVR) technology, independent of collateral ventilation...
  83. ncbi Intervening on cognitions and behavior in irritable bowel syndrome: A feasibility trial using PDAs
    Simone Oerlemans
    NIVEL Netherlands Institute for Health Services Research, Utrecht, The Netherlands
    J Psychosom Res 70:267-77. 2011
    ..The aim of this study was to establish the feasibility and the efficacy of a cognitive-behavioral e-intervention using personal digital assistants (PDAs) on the self-management of IBS patients...
  84. ncbi Minimally invasive endoscopic thyroidectomy by a cervical approach
    W B Inabnet
    Division of Laparoscopic Surgery, Department of Surgery, Mount Sinai Medical Center, 5 East 98th Street, Box 1259, New York, NY 10029, USA
    Surg Endosc 17:1808-11. 2003
    ..The purpose of this prospective review was to assess the feasibility and safety of endoscopic thyroidectomy by a cervical approach...
  85. ncbi Hierarchy of evidence: a framework for ranking evidence evaluating healthcare interventions
    David Evans
    Department of Clinical Nursing, University of Adelaide, South Australia 5005
    J Clin Nurs 12:77-84. 2003
    ..However, hierarchies only provide a guide to the strength of the available evidence and other issues such as the quality of research also have an important influence...
  86. ncbi A very early rehabilitation trial for stroke (AVERT): phase II safety and feasibility
    Julie Bernhardt
    National Stroke Research Institute, Level 1, Neurosciences Building, Heidelberg Repatriation Hospital, 300 Waterdale Rd, Heidelberg, 3081 Victoria, Australia
    Stroke 39:390-6. 2008
    ..Very early rehabilitation, with an emphasis on mobilization, may contribute to improved outcomes after stroke. We hypothesized that a very early rehabilitation protocol would be safe and feasible...
  87. ncbi Molecular testing for mutations in improving the fine-needle aspiration diagnosis of thyroid nodules
    Yuri E Nikiforov
    Department of Pathology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Clin Endocrinol Metab 94:2092-8. 2009
    ..However, 10-40% of nodules are diagnosed as indeterminate by cytology, making it difficult to optimally manage these patients...
  88. ncbi Scarless single port transumbilical nephrectomy and pyeloplasty: first clinical report
    Mihir M Desai
    Center for Laparoscopic and Robotic Surgery, Glickman Urological Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    BJU Int 101:83-8. 2008
    ..To report the initial clinical cases of scarless, single port, transumbilical nephrectomy and pyeloplasty...
  89. ncbi Completely transvaginal NOTES cholecystectomy using magnetically anchored instruments
    Daniel J Scott
    Southwestern Center for Minimally Invasive Surgery, Department of Surgery, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9156, USA
    Surg Endosc 21:2308-16. 2007
    ..The purpose of this study was to perform transvaginal cholecystectomies using instruments incorporated into a magnetic anchoring and guidance system (MAGS)...
  90. ncbi Evaluation of a community-based rehabilitation model for chronic schizophrenia in rural India
    Sudipto Chatterjee
    Latrobe Regional Hospital, Traralgon Victoria, Australia
    Br J Psychiatry 182:57-62. 2003
    ..Community-based rehabilitation (CBR) is a model of care which has been widely used for physical disabilities in resource-poor settings...
  91. ncbi The Short FES-I: a shortened version of the falls efficacy scale-international to assess fear of falling
    Gertrudis I J M Kempen
    School for Public Health and Primary Care, Maastricht University, The Netherlands
    Age Ageing 37:45-50. 2008
    ..the 16-item Falls Efficacy Scale-International (FES-I) has been shown to have excellent reliability and construct validity. However, for practical and clinical purposes, a shortened version of the FES-I would be useful...
  92. ncbi Early experience with two-stage laparoscopic Roux-en-Y gastric bypass as an alternative in the super-super obese patient
    J P Regan
    Division of Laparoscopic Surgery, Department of Surgery, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1103, New York, NY, USA
    Obes Surg 13:861-4. 2003
    ..Current limited experience exists with a two-stage biliopancreatic diversion and duodenal switch in the supersuper obese patient, and we now present our early experience with a two-stage gastric bypass for these patients...
  93. ncbi Catheter-based autologous bone marrow myocardial injection in no-option patients with advanced coronary artery disease: a feasibility study
    Shmuel Fuchs
    Cardiovascular Research Institute, MedStar Research Institute, Washington Hospital Center, 110 Irving Street NW, 4B 1, Washington, DC 20010, USA
    J Am Coll Cardiol 41:1721-4. 2003
    ..We conducted a pilot study to evaluate the feasibility of transendocardial delivery of autologous bone marrow (ABM) strategy in patients with severe symptomatic chronic myocardial ischemia not amenable to conventional revascularization...
  94. ncbi Cardiovascular magnetic resonance myocardial feature tracking for quantitative viability assessment in ischemic cardiomyopathy
    Andreas Schuster
    Division of Imaging Sciences and Biomedical Engineering, The Rayne Institute, St Thomas Hospital, London, UK
    Int J Cardiol 166:413-20. 2013
    ....
  95. ncbi Percutaneous mitral valve repair using the edge-to-edge technique: six-month results of the EVEREST Phase I Clinical Trial
    Ted Feldman
    Evanston Hospital, Cardiology Division Burch 300, Evanston, Illinois 60201, USA
    J Am Coll Cardiol 46:2134-40. 2005
    ..This study sought to evaluate the clinical results of a percutaneous approach to mitral valve repair for mitral regurgitation (MR)...
  96. ncbi 18F-labeled fluorodeoxyglucose positron emission tomography-guided surgery for recurrent colorectal cancer: a feasibility study
    E E Zervos
    Division of Surgical Oncology, Arthur G James Cancer Center, Columbus, Ohio 43210, USA
    J Surg Res 97:9-13. 2001
    ..The purpose of this study was to determine whether diagnostic information offered by preoperative PET scan could be used to detect disease intraoperatively using beta and gamma handheld probes...
  97. pmc Feasibility of a mobile phone-based data service for functional insulin treatment of type 1 diabetes mellitus patients
    Alexander Kollmann
    Department of eHealth Systems, Austrian Research Centers GmbH ARC, Graz, Austria
    J Med Internet Res 9:e36. 2007
    ..Thus, mobile phones have the potential to assist in daily diabetes management and to enable a telemedical interaction between patients and health care professionals...
  98. pmc Feasibility and value of PatientViewpoint: a web system for patient-reported outcomes assessment in clinical practice
    Claire F Snyder
    Division of General Internal Medicine, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205 1901, USA
    Psychooncology 22:895-901. 2013
    ..This pilot test evaluated PatientViewpoint's use, usefulness, and acceptability to patients and clinicians...
  99. ncbi Video-assisted thoracic surgery lobectomy: single institutional experience with 704 cases
    Kwhanmien Kim
    Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Ann Thorac Surg 89:S2118-22. 2010
    ..However, questions remain as to whether VATS lobectomy reduces local recurrence and improves long-term survival in patients with NSCLC...
  100. pmc Feasibility of using teleradiology to improve tuberculosis screening and case management in a district hospital in Malawi
    Rebecca Marie Coulborn
    Medecins Sans Frontieres, PO Box 219, Thyolo, Malawi
    Bull World Health Organ 90:705-11. 2012
    ..5%). Tuberculosis, common among HIV-infected people, requires radiologic diagnosis, yet Malawi has no radiologists in public service. This hinders rapid and accurate diagnosis and increases morbidity and mortality...
  101. ncbi Fractionated stereotactic radiotherapy boost for gynecologic tumors: an alternative to brachytherapy?
    Meritxell Molla
    Servei de Radio Oncologia, Instituto Oncologico Teknon, Barcelona, Spain
    Int J Radiat Oncol Biol Phys 62:118-24. 2005
    ..We aimed to challenge this treatment standard by using stereotactic radiotherapy (SRT) with a linac-based micromultileaf collimator technique...

Research Grants74

  1. NIEHS SUPPORT OF THE AHS COHORT STUDY AT NCI
    Charles Knott; Fiscal Year: 2010
    ..Several feasibility studies have been conducted among migrant and seasonal farm workers to determine appropriate methods for ..
  2. THE AGRICULTURAL HEALTH STUDY - FIELD STATIONS
    Charles Lynch; Fiscal Year: 2010
    ..Several feasibility studies have been conducted among migrant and seasonal farm workers to determine appropriate methods for ..
  3. Bone Deficits and Excess Adiposity after Pediatric Bone Marrow Transplantation
    Sogol Mostoufi-Moab; Fiscal Year: 2013
    ..and (3) preparation of multiple peer-reviewed grants during the award to secure support for pilot and feasibility studies of potential interventions, while conducting research during the award period...
  4. Nitric Oxide in Hemodialysis AV Fistula Maturation
    Richard A Cohen; Fiscal Year: 2010
    ..In this R21 application we propose proof- of-concept and feasibility studies to provide the groundwork for a more definitive investigation of this hypothesis that should lead to ..
  5. FEASIBILITY OF REPAIRING GBM DEFECTS IN VIVO
    Jeffrey H Miner; Fiscal Year: 2012
    ..The results of these feasibility studies will have implications not only for treating human kidney disease, but also for our basic understanding of ..
  6. FUNCTION OF THE ENTERIC NERVOUS SYSTEM
    JACKIE WOOD; Fiscal Year: 2013
    ..and mast cell proteases that we find during electrical or chemical activation of the afferents in pilot/feasibility studies. Aim 3...
  7. Neutralizing Antibodies for Complement Inhibition
    REKHA BANSAL; Fiscal Year: 2010
    ..The goals of this phase I SBIR is to complete feasibility studies demonstrating the therapeutic value of developing this cutting-edge monoclonal antibody technololgy to ..
  8. Reducing Weight and Diabetes Risk in an Underserved Population
    Carla A Green; Fiscal Year: 2012
    ..are effective at reducing weight and other diabetes risk factors in general populations, and pilot and feasibility studies suggest that such interventions will be effective with individuals who have mental illnesses, no large-..
  9. Computational Modeling and Accelerated Aging of the Ascending Aorta
    Jay D Humphrey; Fiscal Year: 2013
    ..model capable of modeling the unique evolving histo-mechanics of the ascending aorta), and "pilot or feasibility studies" (i.e., initial validation studies using fibulin 5 null mice, which show accelerated aging)...
  10. Treating Low-Income Smokers in the Hospital Emergency Department
    Steven L Bernstein; Fiscal Year: 2013
    ..Based on our feasibility studies, the Institute of Medicine 2006 report on tobacco and the 2008 US Public Health Service guidelines now list ..
  11. Anti-Inflammatory Interventions in Maintenance Hemodialysis Patients
    Talat Alp Ikizler; Fiscal Year: 2013
    ..network of investigators and dialysis facilities for efficient and swift subject recruitment for pilot and feasibility studies in maintenance hemodialysis patients...
  12. An Integrated Nano-Cell Delivery Platform of Theranostics for Lung Cancers
    Subhra Mohapatra; Fiscal Year: 2013
    ..have access to all reagents and methods and have already developed necessary collaborations and feasibility studies. The results of the proposed studies are expected to validate NPRA as a therapeutic target for lung cancer ..
  13. Identification of Biomarkers for BBB Injury-Induced by Drugs and HIV-1 Proteins
    Sheng He Huang; Fiscal Year: 2013
    ..The overall goal of this pilot project is to perform feasibility studies on the development of new cell-based biomarkers of the BBB disorders induced by drug abuse (NT) and HIV VFs ..
  14. Producing micturition by combined afferent and effernet electrical stimulation
    Kenneth J Gustafson; Fiscal Year: 2010
    ..with SCI to quantify the effectiveness of this approach and to translate animal model results to human feasibility studies. This approach to restoration of bladder voiding is expected to increase our understanding of afferent-..
  15. Novel Methods for Dissolving Blood Clots
    GUY LELAND REED; Fiscal Year: 2013
    ..In our Phase I STTR feasibility studies, we successfully converted this molecule, following FDA guidance, into a clot-dissolving biologic ..
  16. Modulated Imaging: A Wide-field Optical Imaging Platform for Clinical Research
    Anthony J Durkin; Fiscal Year: 2010
    ..Leveraging existing IRB approved clinical protocols and ongoing LAMMP- related studies, we will perform feasibility studies for skin-related applications, including normal skin, port-wine stain, melanoma, and skin flap surgeries...
  17. A multicenter outpatient trial of a bihormonal bionic pancreas
    Steven J Russell; Fiscal Year: 2013
    ..extensively tested our hormonal BP in preclinical pig studies at Boston University (BU) and in inpatient feasibility studies in pediatrics and adults with type 1 diabetes at the Massachusetts General Hospital (MGH)...
  18. Self-Complementary AAV2 Factor IX for Hemophilia B
    SCOTT WILLIAM JOHN MCPHEE; Fiscal Year: 2010
    ..Specifically, feasibility studies demonstrate improved expression from our incorporation of a novel genomic structure, self-complementary ..
  19. Feasibility of Pharmacy-Based HIV Interventions among IDUs: Ha Giang, Vietnam
    NANCY PIELEMEIER; Fiscal Year: 2010
    ..There are important methodological and contextual advantages of conducting feasibility studies in a diverse set of domestic and international sites...
  20. The Role of Alzheimer's-associated Abeta in POD and POCD
    Zhongcong Xie; Fiscal Year: 2012
    ..levels with POCD measured 7 days, 3 months, and 1 year after surgery in the same population;(3) to perform feasibility studies of using positron emission tomographic imaging with Pittsburgh Compound B to measure brain amyloid amount ..
  21. Nanotechnology enabled desktop image-guided microbeam radiation therapy system
    OTTO Z contact ZHOU; Fiscal Year: 2010
    ..We have already carried out initial feasibility studies and they indicate that the novel desktop system is capable of producing characteristic MRT radiation ..
  22. Flexible Work and Well-Being Center at the University of Minnesota
    ERIN L KELLY; Fiscal Year: 2013
    ..During Phase 1, WFHN designed and conducted multiple pilot and feasibility studies. For Phase 2, the WFHN has been called upon to implement an innovative intervention and to evaluate the ..
  23. An EP4 receptor agonist for enhancing alveolar bone regeneration in tooth-extract
    JAMES PAUL O apos MALLEY; Fiscal Year: 2010
    ..It is expected that the success of these feasibility studies will lead to a Phase II Proof of Principal study which, if successful, will generate sufficient interest ..
  24. Hormonal Induction Mouse Models of Prostate Cancer
    Maarten C Bosland; Fiscal Year: 2010
    ..is in response to PA-08-055, "Cancer Prevention Research Small Grant Program (R03)", proposing pilot-feasibility studies that address the development of innovative animal models to mimic the human [prostate] cancer process in ..
  25. Investigating the Role of a Lifestyle Intervention on Novel Estrogen Biomarkers
    Kerryn W Reding; Fiscal Year: 2011
    ..Results: The results from the pilot and feasibility studies will be used to provide preliminary data for an R01 application proposing to investigate the hypothesis ..
  26. Novel Micro-Implant to Measure Intracardiac Pressure in Congenital Heart Patients
    Nader Najafi; Fiscal Year: 2013
    ..Finally, this study will support investigators during the application process to obtain Investigational Device Exemption from the FDA for the initial feasibility studies in infants with these complex forms of congenital heart disease.
  27. Community-Based Lifestyle Promotion With Latino Women
    Deborah Koniak Griffin; Fiscal Year: 2010
    ..The study builds upon formative and feasibility studies implemented using community-based participatory research methods and materials developed in a NHLBI CVD ..
  28. Center for Research Translation in Scleroderma
    MAUREEN MAUREEN MAYES; Fiscal Year: 2010
    ..Core for facilitating UTH-CORT-SSc translational research activities and selecting novel Pilot and Feasibility studies. The studies proposed here will provide better understanding of both the fundamental pathogenetic ..
  29. Efficacy and Safety of an Aerosolized Recombinant Butyrylcholinesterase Pretreatm
    YVONNE J ROSENBERG; Fiscal Year: 2013
    ..In Phase I Phase I feasibility studies, aer-rBChE was shown to protect against paraoxon (Px) toxicity in mice while in Phase II, unmodified aer-..
  30. Development of Novel p38 MAPK Inhibitors as Therapeutics for CNS Disorders
    DANIEL MARTIN WATTERSON; Fiscal Year: 2012
    ..among neurodegenerative disorders, glia activation and increased levels of proinflammatory cytokines, with feasibility studies using macromolecular therapeutics suggestive of a positive clinical effect of proinflammatory cytokine ..
  31. New Avenues to Increase the Use of Skilled Birth Attendants in Ghana
    Jody Rae Lori; Fiscal Year: 2013
    ..The research project will allow for experiences in conducting community based research, feasibility studies in low resource clinic settings, and the use of quasi-experimental design in examining program ..
  32. The Role of the Skin Barrier in Atopic Dermatitis Development and Prevention
    Eric L Simpson; Fiscal Year: 2013
    ..An international research consortium is currently in place awaiting direction from these proposed feasibility studies. The current proposal will not definitely answer whether skin barrier protection effectively prevents AD, ..
  33. Parallel Solid-State Electrodes for Turn-Key Intracellular Electrophysiology
    Ari Chaney; Fiscal Year: 2013
    ..Using support from a Phase I SBIR grant, we will refine the device and perform feasibility studies of this game changing, inexpensive, and easy-to-use intracellular recording platform...
  34. Targeted Therapy for Non Small Cell Lung Carcinoma: In vivo Feasibility Studies
    Ginette Serrero; Fiscal Year: 2012
    ..The present application proposes feasibility studies to investigate if this agent can be inhibit lung cancer, particularly on small cell lung carcinoma...
  35. Contrast-Enhanced and Image-Guided Surgery of Lung Cancer
    Sunil Singhal; Fiscal Year: 2013
    ..green or ICG) and its albumin complexes, and will be used for device optimization and accelerated clinical feasibility studies. The second type of contrast agents is based on pegylated colloidal gold and surface-enhanced Raman ..
  36. Temperature Modulated-Fluorescence Tomography: A New Modality for Cancer Imaging
    TIFFANY KWONG; Fiscal Year: 2013
    ..This training proposal is geared toward the first in vivo feasibility studies of this nove imaging modality...
  37. RU: Daily Diary Evaluation of the Health Benefits of a Workplace Intervention
    David M Almeida; Fiscal Year: 2013
    ..During Phase 1, WFHN designed and conducted multiple pilot and feasibility studies. For Phase 2, the WFHN has been called upon to implement an innovative intervention based on Phase I pilot ..
  38. Evaluating the Health Benefits of Workplace Policies and Practices - Phase II
    Lisa F Berkman; Fiscal Year: 2012
    ..During Phase 1, WFHN designed and conducted multiple pilot and feasibility studies. For Phase 2, the WFHN has been called upon to implement an innovative intervention based on Phase I pilot ..
  39. Role of Prostatic Fibrosis in BPH/LUTS Development &Symptomology
    Jill A Macoska; Fiscal Year: 2011
    ..The Center team has designed feasibility studies that employ quantitative approaches designed to measure fibrotic changes in human and mouse tissues and ..
  40. Percutaneous cardiac HIFU ablation with multimodal image guidance
    Douglas N Stephens; Fiscal Year: 2013
    ..work are as follows: 1) Develop a large-scale prototype (15-mm footprint) CMUT array for use in initial feasibility studies and a clinically suitable, small-scale (7-mm footprint) CMUT array integrated with supporting frontend ..
  41. A membrane-based immunotherapy for triple negative breast cancer
    Christopher D Pack; Fiscal Year: 2013
    ..Completion of the proposed SBIR Phase I feasibility studies will demonstrate the efficacy of membrane-based immunotherapy in inhibiting the metastatic growth of triple ..
  42. A non-invasive nanotechnology-based skin patch for multiplexed diagnostics
    LANCE ALLEN LIOTTA; Fiscal Year: 2012
    ..Our feasibility studies demonstrate virtually 100 percent capture and 100 percent elution yield of low abundance interleukins in ..
  43. Center for Work-Family Stress, Safety &Health: Portland State University RU
    LESLIE HAMMER; Fiscal Year: 2012
    ..During Phase 1, WFHN designed and conducted multiple pilot and feasibility studies. For Phase 2, the WFHN has been called upon to implement an innovative intervention based on Phase I pilot ..
  44. Targeted genomic characterization of uncultured bacteria from the human microbiot
    Mircea Podar; Fiscal Year: 2011
    ..Initial feasibility studies indicate that our approach can be applied to any microbial consortia and is not dependent on the abundance ..
  45. Translatioanl studies of a bionic pancreas for out-patient diabetes management
    Steven J Russell; Fiscal Year: 2013
    ..BG control system in preclinical studies in diabetic swine at Boston University (BU) and in clinical feasibility studies in pediatric and adult subjects with type 1 diabetes in the Clinical Research Center (CRC) at the ..
  46. Feasibility Studies for Clinical Trials
    Yang Lu; Fiscal Year: 2011
    ..This feasibility study will provide preliminary data for a future randomized clinical trial of peer mentoring to improve adherence among adolescents and young adults with T1D. ..
  47. One-Step, POC Sample-to-Answer Process for RNA Analysis Outside the Laboratory
    John E Mueller; Fiscal Year: 2013
    ..During our initial Phase I, feasibility studies will focus on the purification and detection of genomic dengue RNA...
  48. Investigating the Role of a Lifestyle Intervention on Novel Estrogen Biomarkers
    Kerryn W Reding; Fiscal Year: 2013
    ..Results: The results from the pilot and feasibility studies will be used to provide preliminary data for an R01 application proposing to investigate the hypothesis ..
  49. Exercise and Stem Cell Engraftment in the Heart Following Myocardial Infarction
    KENNETH BER MARGULIES; Fiscal Year: 2013
    ..b>Feasibility studies from our laboratory support these hypotheses, and results from the proposed studies will provide crucial ..
  50. A Translational Coordinating Center for the Work, Family and Health Network
    Ginger C Hanson; Fiscal Year: 2013
    ..During Phase 1, WFHN designed and conducted multiple pilot and feasibility studies. For Phase 2, the WFHN has been called upon to implement an innovative intervention and to evaluate the ..
  51. Carbon Nanopipette Cellular Probe for Microinjections into Mammalian Cells
    CHAMIKA WANSAPURA; Fiscal Year: 2010
    ..b>Feasibility studies will be performed using CNPs with inner diameter in the ~100 nm range to achieve less damage to cell ..
  52. Reinnervation of Paralyzed Muscle by Nerve-Muscle-Endplate Band Grafting
    Liancai Mu; Fiscal Year: 2011
    ..Cervical strap muscles were selected to perform feasibility studies in a rat model...
  53. Medication development of a novel therapeutic for smoking cessation
    KENNETH ALAN PERKINS; Fiscal Year: 2013
    ..In the first stage, preclinical feasibility studies will be performed based on highly convincing preliminary data in rodent models that are validated ..
  54. Novel Static Screen Volumetric 3D Display for Medical Image Visualization
    Jason Geng; Fiscal Year: 2010
    ..We have already performed considerable preliminary feasibility studies to verify the validity of the proposed concept and implementation strategy...
  55. Development and Testing of a Device for Enhancing Memory During Sleep
    Alexander F Butterwick; Fiscal Year: 2012
    ..Subsequent to these early feasibility studies, we are particularly interested in memory enhancement for individuals with neurodevelopment disorders such ..
  56. Direct and Quantitative Proteomic Approaches in Xenopus
    Ileana M Cristea; Fiscal Year: 2013
    ..Specifically, we propose a series of feasibility studies based on three proteins, the T-box transcription factors TBX5, the zinc finger transcription factor CASZ1, ..
  57. Metachromatic Leukodystrophy Enzyme Drug Development
    KA WAI HUI; Fiscal Year: 2012
    ..b>Feasibility studies with the HIRMAb-ASA fusion protein were enabled following the cloning of a high producing, stably ..
  58. Automated Medication Transfer Between a Pharmacy Dispensing System and a Mobile D
    Daniel A Theobald; Fiscal Year: 2010
    ..Vecna hypothesizes that the feasibility studies and resultant proposed protocols, procedures, and mechanisms, if successful, will lead to a streamlined ..
  59. Technology to connect at-risk youth to testing
    Marguerita A Lightfoot; Fiscal Year: 2013
    ..In response to PA-09-146 (Pilot and Feasibility Studies in Preparation for Drug Abuse Prevention Trials [r34]), we propose a pilot study to examine the ..
  60. Mayo Clinic Metabolomics Resource Core
    K Sreekumaran Nair; Fiscal Year: 2013
    ..In addition, we propose an outreach and education program which will support feasibility studies and provide education and training opportunities to investigators wishing to utilize these techniques...
  61. NATIONAL BIOMEDICAL NMR RESOURCE AT MADISON
    JOHN LUTE MARKLEY; Fiscal Year: 2013
    ..or more of the following steps: (1) strategy evaluation and experiment design, (2) sample preparaton, (3) feasibility studies, (4) data collection, (5) data analysis and structure determination, (6) data validation and deposition, ..
  62. NATIONAL BIOMEDICAL NMR RESOURCE AT MADISON
    John L Markley; Fiscal Year: 2011
    ..or more of the following steps: (1) strategy evaluation and experiment design, (2) sample preparaton, (3) feasibility studies, (4) data collection, (5) data analysis and structure determination, (6) data validation and deposition, ..
  63. Rapid High-Resolution Electroanatomical Cardiac Mapping System for the Treatment
    DORON HARLEV; Fiscal Year: 2009
    ..On the heels of previously performed feasibility studies, Phase I of the proposed project will include the development of a prototype system comprised of a ..
  64. DEVELOPMENT OF NOVEL BIOMARKERS FOR ALZHEIMER'S DISEASE
    James Moe; Fiscal Year: 2009
    ..Preliminary feasibility studies with a limited number of CSF samples have indicated that tau oligomers and tau- A21-42 complexes are ..
  65. ASU-UAB EXPORT Project REAP
    Karyn Scissum Gunn; Fiscal Year: 2004
    ..The ASU-UAB Project REAP will operate from four distinct but intercommunicating Cores: Through the Feasibility Studies Pilot Research Core, one biomedical pilot research project will assess the feasibility of further ..
  66. Phage-mediated bioluminescent detection of Yersinia pestis.
    David Schofield; Fiscal Year: 2009
    ..Specific Aim 2 will perform feasibility studies to demonstrate that the luxAB-phage can effectively be used as a Y. pestis detection system...
  67. A Novel Hydrogel Colorimetric Urea Sensor for Dialysis
    ANJAL SHARMA; Fiscal Year: 2006
    ..During the Phase I effort, we will perform feasibility studies to prove that our colorimetric gels can reversibly and reproducibly monitor changing urea levels in a ..
  68. Potentiating an anthrax DNA vaccine with electroporation
    Brian Livingston; Fiscal Year: 2005
    ..Ichor has already developed a vaccine applicator suitable for clinical studies. Under SBIR Phase I feasibility studies, Ichor has demonstrated, using a research plasmid, that electroporation-based immunization against-PA, ..
  69. Versatile Mutation Assay Based on the Pig-A Locus
    Stephen Dertinger; Fiscal Year: 2009
    ..Whereas Phase I feasibility studies were conducted strictly with mice, these experiments will consider exposures of both mice and rats to each ..
  70. Novel immunoprophylactic agents against Staphylococcus aureus
    Lisa Herron Olson; Fiscal Year: 2009
    ..aureus infection, Phase I feasibility studies with three specific aims are proposed: Aim 1 will identify antigens in the IRPE fraction against which ..
  71. MULTIPURPOSE ARTHRITIS & MUSCULOSKELETAL DISEASES CENTER
    MATTHEW LIANG; Fiscal Year: 2000
    ..Center (MAC) and supports an Administrative unit, 3 Cores, 3 clinical science grants, and 4 development and feasibility studies. The Cores, Biometry, Morphology and DNA Sequencing, support a variety of biomedical and clinical studies ..
  72. REGULATED OSTEOINDUCTIVE PLASMID GENE TRANSFER VIA GENE
    KEVIN RICE; Fiscal Year: 2002
    ..Successful feasibility studies have been conducted in rat and canine models, and this work has shown for the first time that new bone will ..
  73. HUMAN AUDITORY CORTEX PHYSIOLOGY
    Matthew Howard; Fiscal Year: 2000
    ..The two specific areas of investigation will be: l) Cellular electrophysiology of human auditory cortex, 2) Feasibility studies of an auditory cortex neural prosthetic device concept...
  74. SEQUENCING THE DICTYOSTELIUM GENOME
    Adam Kuspa; Fiscal Year: 2004
    ..The previous project period focused on feasibility studies and the sequencing of chromosome 6...