cohort studies

Summary

Summary: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.

Top Publications

  1. ncbi Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care
    D C Angus
    Critical Care Medicine Division, Department of Anesthesiology and Critical Care Medicine, and the Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 29:1303-10. 2001
  2. ncbi Prediction of coronary heart disease using risk factor categories
    P W Wilson
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Mass 01701, USA
    Circulation 97:1837-47. 1998
  3. ncbi Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults
    Eugenia E Calle
    Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta 30329, USA
    N Engl J Med 348:1625-38. 2003
  4. ncbi Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland
    P Lichtenstein
    Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden
    N Engl J Med 343:78-85. 2000
  5. ncbi Frailty in older adults: evidence for a phenotype
    L P Fried
    Center on Aging and Health, The John Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    J Gerontol A Biol Sci Med Sci 56:M146-56. 2001
  6. ncbi A gene-expression signature as a predictor of survival in breast cancer
    Marc J van de Vijver
    Division of Diagnostic Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands
    N Engl J Med 347:1999-2009. 2002
  7. ncbi The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies
    Erik von Elm
    Institute of Social and Preventive Medicine ISPM, University of Bern, Bern, Switzerland
    Lancet 370:1453-7. 2007
  8. pmc A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
    Timothy M Frayling
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter, UK
    Science 316:889-94. 2007
  9. ncbi What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes
    J Zhang
    Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 7510, USA
    JAMA 280:1690-1. 1998
  10. pmc Maternal and child undernutrition: consequences for adult health and human capital
    Cesar G Victora
    Universidade Federal de Pelotas, Pelotas, Brazil
    Lancet 371:340-57. 2008

Detail Information

Publications353 found, 100 shown here

  1. ncbi Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care
    D C Angus
    Critical Care Medicine Division, Department of Anesthesiology and Critical Care Medicine, and the Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 29:1303-10. 2001
    ..To determine the incidence, cost, and outcome of severe sepsis in the United States...
  2. ncbi Prediction of coronary heart disease using risk factor categories
    P W Wilson
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Mass 01701, USA
    Circulation 97:1837-47. 1998
    ....
  3. ncbi Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults
    Eugenia E Calle
    Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta 30329, USA
    N Engl J Med 348:1625-38. 2003
    ..The influence of excess body weight on the risk of death from cancer has not been fully characterized...
  4. ncbi Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland
    P Lichtenstein
    Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden
    N Engl J Med 343:78-85. 2000
    ..The contribution of hereditary factors to the causation of sporadic cancer is unclear. Studies of twins make it possible to estimate the overall contribution of inherited genes to the development of malignant diseases...
  5. ncbi Frailty in older adults: evidence for a phenotype
    L P Fried
    Center on Aging and Health, The John Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    J Gerontol A Biol Sci Med Sci 56:M146-56. 2001
    ..A standardized definition has not yet been established...
  6. ncbi A gene-expression signature as a predictor of survival in breast cancer
    Marc J van de Vijver
    Division of Diagnostic Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands
    N Engl J Med 347:1999-2009. 2002
    ..A more accurate means of prognostication in breast cancer will improve the selection of patients for adjuvant systemic therapy...
  7. ncbi The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies
    Erik von Elm
    Institute of Social and Preventive Medicine ISPM, University of Bern, Bern, Switzerland
    Lancet 370:1453-7. 2007
    ..We hope that the STROBE statement will contribute to improving the quality of reporting of observational studies..
  8. pmc A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
    Timothy M Frayling
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter, UK
    Science 316:889-94. 2007
    ..67-fold increased odds of obesity when compared with those not inheriting a risk allele. This association was observed from age 7 years upward and reflects a specific increase in fat mass...
  9. ncbi What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes
    J Zhang
    Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 7510, USA
    JAMA 280:1690-1. 1998
    Logistic regression is used frequently in cohort studies and clinical trials...
  10. pmc Maternal and child undernutrition: consequences for adult health and human capital
    Cesar G Victora
    Universidade Federal de Pelotas, Pelotas, Brazil
    Lancet 371:340-57. 2008
    ..We analysed data from five long-standing prospective cohort studies from Brazil, Guatemala, India, the Philippines, and South Africa and noted that indices of maternal and child ..
  11. pmc Genome-wide association analysis of metabolic traits in a birth cohort from a founder population
    Chiara Sabatti
    Department of Human Genetics and Los Angeles, Los Angeles, California 90095, USA
    Nat Genet 41:35-46. 2009
    ..The association observed between low-density lipoprotein and an infrequent variant in AR suggests the potential of such a cohort for identifying associations with both common, low-impact and rarer, high-impact quantitative trait loci...
  12. ncbi The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies
    Erik von Elm
    Institute of Social and Preventive Medicine, University of Bern, 3012 Bern, Switzerland
    J Clin Epidemiol 61:344-9. 2008
    ..We hope that the STROBE Statement will contribute to improving the quality of reporting of observational studies...
  13. ncbi Estimating the relative risk in cohort studies and clinical trials of common outcomes
    Louise Anne McNutt
    Department of Epidemiology, School of Public Health, University at Albany, State University of New York, Rensselaer, NY 12144, USA
    Am J Epidemiol 157:940-3. 2003
    ..Hypothetical data are used to illustrate statistical methods with readily accessible computer software...
  14. ncbi Multiple imputation of missing blood pressure covariates in survival analysis
    S van Buuren
    TNO Prevention and Health, Department of Statistics, Leiden, The Netherlands
    Stat Med 18:681-94. 1999
    ..Risk estimates for these data appear robust to even large departures from the simplest non-response model, and are similar to those derived under deletion of the incomplete records...
  15. pmc Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
    John B Harley
    Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, Oklahoma 73104, USA
    Nat Genet 40:204-10. 2008
    ..Our results show that numerous genes, some with known immune-related functions, predispose to SLE...
  16. ncbi Incidence and outcomes of acute lung injury
    Gordon D Rubenfeld
    Division of Pulmonary and Critical Care Medicine, Harborview Medical Center, Seattle, WA 98104 2499, USA
    N Engl J Med 353:1685-93. 2005
    ..Despite recent advances in our understanding of the mechanism and treatment of acute lung injury, its incidence and outcomes in the United States have been unclear...
  17. ncbi Multi-ethnic study of atherosclerosis: objectives and design
    Diane E Bild
    Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD, USA
    Am J Epidemiol 156:871-81. 2002
    ....
  18. ncbi 2009 influenza A(H1N1) seroconversion rates and risk factors among distinct adult cohorts in Singapore
    Mark I C Chen
    Tan Tock Seng Hospital, Department of Clinical Epidemiology, 11 Jalan Tan Tock Seng, Singapore, 308433
    JAMA 303:1383-91. 2010
    ..Singapore experienced a single epidemic wave of 2009 influenza A(H1N1) with epidemic activity starting in late June 2009 and peaking in early August before subsiding within a month...
  19. ncbi Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    Circulation 116:39-48. 2007
    ..The incremental utility of measuring both visceral and subcutaneous abdominal adipose tissue (SAT) in association with metabolic risk factors and underlying heritability has not been well described in a population-based setting...
  20. ncbi Diet, lifestyle, and the risk of type 2 diabetes mellitus in women
    F B Hu
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    N Engl J Med 345:790-7. 2001
    ..Previous studies have examined individual dietary and lifestyle factors in relation to type 2 diabetes, but the combined effects of these factors are largely unknown...
  21. ncbi Cohort profile: the Norwegian Mother and Child Cohort Study (MoBa)
    Per Magnus
    Division of Epidemiology, The Norwegian Institute of Public Health, Oslo, Norway
    Int J Epidemiol 35:1146-50. 2006
  22. pmc Cohort profile: the 45 and up study
    Emily Banks
    Sax Institute, Sydney, Australia
    Int J Epidemiol 37:941-7. 2008
  23. ncbi Overall C as a measure of discrimination in survival analysis: model specific population value and confidence interval estimation
    Michael J Pencina
    Statistics and Consulting Unit, Department of Mathematics and Statistics, Boston University, 111 Cummington St, MA 02215, USA
    Stat Med 23:2109-23. 2004
    ..Then we investigate via simulations the length and coverage probability of this interval. Finally, we present a real life example evaluating the performance of a Framingham Heart Study model...
  24. pmc Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
    Yurii S Aulchenko
    1 Department of Epidemiology and Biostatistics, Erasmus University Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands 2 These authors contributed equally to this work
    Nat Genet 41:47-55. 2009
    ..001) and coronary heart disease incidence (P = 0.04). The genetic risk score improves the screening of high-risk groups of dyslipidemia over classical risk factors...
  25. ncbi The influence of glucose-lowering therapies on cancer risk in type 2 diabetes
    C J Currie
    School of Medicine, Cardiff University, The Pharma Research Centre, Cardiff Medicentre, Cardiff, CF14 4UJ, UK
    Diabetologia 52:1766-77. 2009
    ..We examined the risk of development of solid tumours in relation to treatment with oral agents, human insulin and insulin analogues...
  26. pmc Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
    Cristen J Willer
    Genetic Investigation of ANthropometric Traits Consortium
    Nat Genet 41:25-34. 2009
    ..Several of the likely causal genes are highly expressed or known to act in the central nervous system (CNS), emphasizing, as in rare monogenic forms of obesity, the role of the CNS in predisposition to obesity...
  27. ncbi The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men
    Hanna Maaria Lakka
    Research Institute of Public Health, University of Kuopio, Finland
    JAMA 288:2709-16. 2002
    ..Despite its high prevalence, little is known of the prospective association of the metabolic syndrome with cardiovascular and overall mortality...
  28. ncbi Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin
    Samantha L Bowker
    Institute of Health Economics, Edmonton, Alberta, Canada
    Diabetes Care 29:254-8. 2006
    ..We explored the association between antidiabetic therapies and cancer-related mortality in patients with type 2 diabetes, postulating that agents that increase insulin levels might promote cancer...
  29. pmc Age and gender differences in physical capability levels from mid-life onwards: the harmonisation and meta-analysis of data from eight UK cohort studies
    Rachel Cooper
    MRC Unit for Lifelong Health and Ageing, Division of Population Health, University College London, London, United Kingdom
    PLoS ONE 6:e27899. 2011
    ..measures of physical capability but provides a demonstration that harmonisation of data from several large cohort studies is possible...
  30. ncbi The humoral immune system has a key prognostic impact in node-negative breast cancer
    Marcus Schmidt
    Department of Obstetrics and Gynecology, Medical School, Johannes Gutenberg University, Mainz, Germany
    Cancer Res 68:5405-13. 2008
    ..83; 95% CI, 0.7-0.97). Thus, we could show in three cohorts of untreated, node-negative breast cancer patients that the humoral immune system plays a pivotal role in metastasis-free survival of carcinomas of the breast...
  31. ncbi Validity and repeatability of a simple index derived from the short physical activity questionnaire used in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
    Nicholas J Wareham
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Robinson Way, CB2 2SR, UK
    Public Health Nutr 6:407-13. 2003
    ....
  32. pmc Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy
    Peter W Hunt
    Positive Health Program, San Francisco General Hospital, Bldg 80, Ward 84, 995 Potrero Ave, San Francisco, CA 94110, USA
    J Infect Dis 197:126-33. 2008
    ....
  33. ncbi Effect of point-of-care CD4 cell count tests on retention of patients and rates of antiretroviral therapy initiation in primary health clinics: an observational cohort study
    Ilesh V Jani
    Instituto Nacional da Saúde, Maputo, Mozambique
    Lancet 378:1572-9. 2011
    ..We implemented point-of-care counting of CD4 cells in Mozambique and assessed the effect on loss to follow-up before immunological staging and treatment initiation...
  34. ncbi Cohort Profile: The 1946 National Birth Cohort (MRC National Survey of Health and Development)
    Michael Wadsworth
    MRC National Survey of Health and Development, Royal Free and UCL Medical School, Department of Epidemiology and Public Health, 1 19 Torrington Place, London WC1E 6BT, UK
    Int J Epidemiol 35:49-54. 2006
  35. pmc Life expectancies of South African adults starting antiretroviral treatment: collaborative analysis of cohort studies
    Leigh F Johnson
    Centre for Infectious Disease Epidemiology and Research, University of Cape Town, Cape Town, South Africa
    PLoS Med 10:e1001418. 2013
    ..We aimed to estimate the life expectancy of patients starting ART in South Africa and compare it with that of HIV-negative adults...
  36. pmc Pioglitazone and risk of bladder cancer among diabetic patients in France: a population-based cohort study
    A Neumann
    Caisse Nationale de l Assurance Maladie, 50 Avenue du Pr André Lemierre, 75986 Paris Cedex 20, France
    Diabetologia 55:1953-62. 2012
    ..Previous studies have suggested an increased risk of bladder cancer with pioglitazone exposure. We aimed to investigate the association between pioglitazone exposure and bladder cancer in France...
  37. ncbi Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus
    Peter W F Wilson
    The NHLBI s Framingham Heart Study, Framingham, Massachusetts, USA
    Circulation 112:3066-72. 2005
    ..The objective was to investigate risk for CVD, CHD, and T2DM according to metabolic syndrome traits...
  38. pmc Childhood adversities increase the risk of psychosis: a meta-analysis of patient-control, prospective- and cross-sectional cohort studies
    Filippo Varese
    Institute of Psychology, Health and Society University of Liverpool, UK
    Schizophr Bull 38:661-71. 2012
    ..We included prospective cohort studies, large-scale cross-sectional studies investigating the association between childhood adversity and psychotic ..
  39. pmc New loci associated with kidney function and chronic kidney disease
    Anna Kottgen
    Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
    Nat Genet 42:376-84. 2010
    ..These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney...
  40. pmc Early life risk factors for obesity in childhood: cohort study
    John J Reilly
    University of Glasgow Division of Developmental Medicine, Yorkhill Hospitals, Glasgow G3 8SJ
    BMJ 330:1357. 2005
    ..To identify risk factors in early life (up to 3 years of age) for obesity in children in the United Kingdom...
  41. ncbi Physical activity from childhood to adulthood: a 21-year tracking study
    Risto Telama
    LIKES Research Center, Keltavuokko 4C, 40520 Jyväskylä, Finland
    Am J Prev Med 28:267-73. 2005
    ....
  42. pmc A whole-genome association study of major determinants for host control of HIV-1
    Jacques Fellay
    Center for Population Genomics and Pharmacogenetics, Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC 27710, USA
    Science 317:944-7. 2007
    ..These findings emphasize the importance of studying human genetic variation as a guide to combating infectious agents...
  43. ncbi Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype
    Maggie C U Cheang
    Genetic Pathology Evaluation Centre, Vancouver Coastal Health Research Institute, British Columbia Cancer Agency, and University of British Columbia, Vancouver, British Columbia, Canada
    Clin Cancer Res 14:1368-76. 2008
    ..This study directly compares the prognostic significance between three- and five-biomarker surrogate panels to define intrinsic breast cancer subtypes, using a large clinically annotated series of breast tumors...
  44. pmc Stable and unstable malaria hotspots in longitudinal cohort studies in Kenya
    Philip Bejon
    Kilifi KEMRI Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    PLoS Med 7:e1000304. 2010
    ..This heterogeneity reduces the efficacy of control strategies, but also implies that focusing control strategies on "hotspots" of transmission could be highly effective...
  45. ncbi X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization
    Robert L Camp
    Department of Pathology, Yale University, School of Medicine, New Haven, Connecticut 06520, USA
    Clin Cancer Res 10:7252-9. 2004
    ....
  46. pmc New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes
    Gillian Libby
    Division of Clinical and Population Sciences and Education, University of Dundee, Dundee, UK
    Diabetes Care 32:1620-5. 2009
    ..Activation of AMPK can suppress tumor formation and inhibit cell growth in addition to lowering blood glucose levels. We tested the hypothesis that metformin reduces the risk of cancer in people with type 2 diabetes...
  47. ncbi Triple-negative breast cancer: clinical features and patterns of recurrence
    Rebecca Dent
    Department of Medical Oncology, Sunnybrook Health Sciences Center, University of Toronto, Ontario, Canada
    Clin Cancer Res 13:4429-34. 2007
    ..To compare the clinical features, natural history, and outcomes for women with "triple-negative" breast cancer with women with other types of breast cancer...
  48. ncbi Diabetes mellitus as a predictor of cancer mortality in a large cohort of US adults
    Steven S Coughlin
    Epidemiology and Applied Research Branch, Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Am J Epidemiol 159:1160-7. 2004
    ..11, 1.45). These associations were not explained by high body mass. Our findings suggest that diabetes is an independent predictor of mortality from cancer of the colon, pancreas, female breast, and, in men, of the liver and bladder...
  49. pmc Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis
    M R Law
    Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts and The London, Queen Mary s School of Medicine and Dentistry, University of London, London EC1M 6BQ
    BMJ 326:1423. 2003
    ..To determine by how much statins reduce serum concentrations of low density lipoprotein (LDL) cholesterol and incidence of ischaemic heart disease (IHD) events and stroke, according to drug, dose, and duration of treatment...
  50. ncbi Mortality in the highly active antiretroviral therapy era: changing causes of death and disease in the HIV outpatient study
    Frank J Palella
    Division of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Acquir Immune Defic Syndr 43:27-34. 2006
    ..AIDS-related death and disease rates have declined in the highly active antiretroviral therapy (HAART) era and remain low; however, current causes of death in HAART-treated patients remain ill defined...
  51. ncbi Cohort profile: 1958 British birth cohort (National Child Development Study)
    Chris Power
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Int J Epidemiol 35:34-41. 2006
  52. ncbi Infections and airway inflammation in chronic obstructive pulmonary disease severe exacerbations
    Alberto Papi
    Research Center on Asthma and COPD, Department of Respiratory Diseases, University of Modena and Reggio Emilia, Via del Pozzo 71, I 41100 Modena, Italy
    Am J Respir Crit Care Med 173:1114-21. 2006
    ..Severe exacerbations of chronic obstructive pulmonary disease (COPD) are major causes of health care costs mostly related to hospitalization. The role of infections in COPD exacerbations is controversial...
  53. pmc New equations to estimate GFR in children with CKD
    George J Schwartz
    Department of Pediatrics, University of Rochester School of Medicine, Rochester, NY 14642, USA
    J Am Soc Nephrol 20:629-37. 2009
    ..413*(height/serum creatinine), provides a good approximation to the estimated GFR formula. Additional studies of children with higher GFR are needed to validate these formulas for use in screening all children for CKD...
  54. pmc Temporal changes in programme outcomes among adult patients initiating antiretroviral therapy across South Africa, 2002-2007
    Morna Cornell
    Centre for Infectious Disease Epidemiology and Research, University of Cape Town, South Africa
    AIDS 24:2263-70. 2010
    ..We describe patient outcomes [mortality, loss-to-follow-up (LTFU) and retention] over time in a network of South African ART cohorts...
  55. pmc Body mass index, waist circumference and waist-hip ratio: which is the better discriminator of cardiovascular disease mortality risk?: evidence from an individual-participant meta-analysis of 82 864 participants from nine cohort studies
    S Czernichow
    Centre for research in Epidemiology and Population Health, Hopital Paul Brousse, Villejuif, France
    Obes Rev 12:680-7. 2011
    ..We conducted an individual-participant meta-analysis of nine cohort studies of men and women drawn from the British general population resulting in sample of 82 864 individuals...
  56. pmc The Generation R Study: design and cohort update 2010
    Vincent W V Jaddoe
    The Generation R Study Group AE006, Erasmus Medical Center, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 25:823-41. 2010
    ..Eventually, results forthcoming from the Generation R Study have to contribute to the development of strategies for optimizing health and healthcare for pregnant women and children...
  57. pmc Arterial stiffness and cardiovascular events: the Framingham Heart Study
    Gary F Mitchell
    Cardiovascular Engineering, Inc, 1 Edgewater Dr, Suite 201A, Norwood, MA 02062, USA
    Circulation 121:505-11. 2010
    ..Various measures of arterial stiffness and wave reflection have been proposed as cardiovascular risk markers. Prior studies have not assessed relations of a comprehensive panel of stiffness measures to prognosis in the community...
  58. ncbi The relationship between reduced lung function and cardiovascular mortality: a population-based study and a systematic review of the literature
    Don D Sin
    Department of Medicine, Respiratory Division, University of British Columbia, and The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 368A, 1081 Burrard St, Vancouver, BC V6Z 1Y6, Canada
    Chest 127:1952-9. 2005
    ..We sought to determine the relationship between reduced FEV1 and cardiovascular mortality, independent of smoking...
  59. ncbi Genetics of gene expression and its effect on disease
    Valur Emilsson
    deCODE Genetics, 101 Reykjavik, Iceland
    Nature 452:423-8. 2008
    ..A core network module in humans and mice was identified that is enriched for genes involved in the inflammatory and immune response and has been found to be causally associated to obesity-related traits...
  60. ncbi HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection
    Salim I Khakoo
    Liver Group, Division of Infection, Inflammation, and Repair, Southampton University, Southampton 5016 6YD, UK
    Science 305:872-4. 2004
    ..The data strongly suggest that inhibitory NK cell interactions are important in determining antiviral immunity and that diminished inhibitory responses confer protection against HCV...
  61. ncbi Genome-wide association study of hematological and biochemical traits in a Japanese population
    Yoichiro Kamatani
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Nat Genet 42:210-5. 2010
    ..05 and 0.01, respectively, and 31 (73.8%) and 27 (64.3%) of the 42 European biochemical loci were replicated...
  62. ncbi Validity of self-reported height and weight in 4808 EPIC-Oxford participants
    Elizabeth A Spencer
    Imperial Cancer Research Fund Cancer Epidemiology Unit, University of Oxford, Gibson Building, The Radcliffe Infirmary, UK
    Public Health Nutr 5:561-5. 2002
    ....
  63. ncbi Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults
    Shaista Malik
    Heart Disease Prevention Program, University of California, Irvine 92697, USA
    Circulation 110:1245-50. 2004
    ..We examined the impact of MetS on CHD, CVD, and overall mortality among US adults...
  64. pmc Milk and dairy consumption and incidence of cardiovascular diseases and all-cause mortality: dose-response meta-analysis of prospective cohort studies
    Sabita S Soedamah-Muthu
    Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    Am J Clin Nutr 93:158-71. 2011
    ..The consumption of dairy products may influence the risk of cardiovascular disease (CVD) and total mortality, but conflicting findings have been reported...
  65. ncbi KORA--a research platform for population based health research
    R Holle
    GSF Forschungszentrum für Umwelt und Gesundheit, Institut für Gesundheitsökonomie und Management im Gesundheitswesen, Neuherberg
    Gesundheitswesen 67:S19-25. 2005
    ..The increasing use of the MONICA/KORA cohorts for a variety of research topics, with a recent focus on genetic epidemiology, indicates the attractiveness of this concept...
  66. ncbi Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy
    Florencia Pereyra
    Partners AIDS Research Center, Massachusetts General Hospital, Boston, MA 02129, USA
    J Infect Dis 197:563-71. 2008
    ..The mechanisms behind this outcome remain largely unknown, and a better understanding of them will likely influence future vaccine strategies...
  67. ncbi Television viewing time and mortality: the Australian Diabetes, Obesity and Lifestyle Study (AusDiab)
    D W Dunstan
    Baker IDI Heart and Diabetes Institute, 250 Kooyong Rd, Caulfield, Victoria, Australia 3162
    Circulation 121:384-91. 2010
    ..We examined the associations of prolonged television viewing time with all-cause, cardiovascular disease (CVD), cancer, and non-CVD/noncancer mortality in Australian adults...
  68. pmc The Rotterdam Study: 2012 objectives and design update
    Albert Hofman
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Epidemiol 26:657-86. 2011
    ..erasmus-epidemiology.nl/rotterdamstudy ). This article gives the rationale of the study and its design. It also presents a summary of the major findings and an update of the objectives and methods...
  69. ncbi Chronic health conditions in adult survivors of childhood cancer
    Kevin C Oeffinger
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York 10021, USA
    N Engl J Med 355:1572-82. 2006
    ..Only a few small studies have assessed the long-term morbidity that follows the treatment of childhood cancer. We determined the incidence and severity of chronic health conditions in adult survivors...
  70. pmc Derivation and validation of QRISK, a new cardiovascular disease risk score for the United Kingdom: prospective open cohort study
    Julia Hippisley-Cox
    Tower Building, University Park, Nottingham NG2 7RD
    BMJ 335:136. 2007
    ..To derive a new cardiovascular disease risk score (QRISK) for the United Kingdom and to validate its performance against the established Framingham cardiovascular disease algorithm and a newly developed Scottish score (ASSIGN)...
  71. ncbi Solid cancer incidence in atomic bomb survivors: 1958-1998
    D L Preston
    Hirosoft International, Eureka, California, USA
    Radiat Res 168:1-64. 2007
    ..In view of the persisting increase in solid cancer risks, the LSS should continue to provide important new information on radiation exposure and solid cancer risks for at least another 15 to 20 years...
  72. ncbi Domains of physical activity and all-cause mortality: systematic review and dose-response meta-analysis of cohort studies
    Guenther Samitz
    Centre of Sports Science and University Sports, University of Vienna, Wien, Austria
    Int J Epidemiol 40:1382-400. 2011
    ..We conducted a systematic review and meta-analysis to determine the association with all-cause mortality of different domains of physical activity and of defined increases in physical activity and energy expenditure...
  73. ncbi The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies
    Erik von Elm
    Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    Ann Intern Med 147:573-7. 2007
    ..annals.org and on the Web sites of PLoS Medicine and Epidemiology. We hope that the STROBE Statement will contribute to improving the quality of reporting of observational studies...
  74. ncbi Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis
    Solbritt Rantapaa-Dahlqvist
    Umea Universitet, Umea, Sweden
    Arthritis Rheum 48:2741-9. 2003
    ....
  75. ncbi A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians
    Yoichiro Kamatani
    Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan
    Nat Genet 41:591-5. 2009
    ..52 and 0.57, respectively). Our findings show that genetic variants in the HLA-DP locus are strongly associated with risk of persistent infection with hepatitis B virus...
  76. ncbi Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: the Special Needs and Autism Project (SNAP)
    Gillian Baird
    Newcomen Centre, Guy s and St Thomas NHS Foundation Trust, London, UK
    Lancet 368:210-5. 2006
    ..Recent reports have suggested that the prevalence of autism and related spectrum disorders (ASDs) is substantially higher than previously recognised. We sought to quantify prevalence of ASDs in children in South Thames, UK...
  77. pmc The Lothian Birth Cohort 1936: a study to examine influences on cognitive ageing from age 11 to age 70 and beyond
    Ian J Deary
    Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
    BMC Geriatr 7:28. 2007
    ..A limitation of many studies is the lack of a sufficiently long period between cognitive assessments to examine determinants. Here, the aim is to examine influences on cognitive ageing between childhood and old age...
  78. ncbi Comparison of community- and health care-associated methicillin-resistant Staphylococcus aureus infection
    Timothy S Naimi
    Acute Disease Investigation and Control Section, Minnesota Department of Health, Minneapolis, USA
    JAMA 290:2976-84. 2003
    ..However, MRSA has emerged in patients without established risk factors (community-associated MRSA)...
  79. ncbi Seven-year experience of a primary care antiretroviral treatment programme in Khayelitsha, South Africa
    Andrew Boulle
    School of Public Health and Family Medicine, University of Cape Town, Anzio Road, Cape Town, South Africa
    AIDS 24:563-72. 2010
    ..We report on outcomes after 7 years of a community-based antiretroviral therapy (ART) programme in Khayelitsha, South Africa, with death registry linkages to correct for mortality under-ascertainment...
  80. ncbi The Danish National Birth Cohort--its background, structure and aim
    J Olsen
    Danish Epidemiology Science Centre, Statens Serum Institut, Copenhagen, Denmark
    Scand J Public Health 29:300-7. 2001
    ..By August 2000. a total of 60,000 pregnant women had been recruited to the study. It is expected that a large number of gene-environmental hypotheses need to be based on case-control analyses within a cohort like this...
  81. pmc A new highly penetrant form of obesity due to deletions on chromosome 16p11.2
    R G Walters
    Section of Genomic Medicine, Imperial College London, London W12 0NN, UK
    Nature 463:671-5. 2010
    ..3). The most productive approach may therefore be to combine the 'power of the extreme' in small, well-phenotyped cohorts, with targeted follow-up in case-control and population cohorts...
  82. ncbi Newly identified loci that influence lipid concentrations and risk of coronary artery disease
    Cristen J Willer
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan, 1420 Washington Heights, Ann Arbor, Michigan 48109, USA
    Nat Genet 40:161-9. 2008
    ..Notably, the 11 independent variants associated with increased LDL cholesterol concentrations in our study also showed increased frequency in a sample of coronary artery disease cases versus controls...
  83. pmc Risk of malignancies in patients with diabetes treated with human insulin or insulin analogues: a cohort study
    L G Hemkens
    Institute for Quality and Efficiency in Health Care IQWiG, Dillenburger Strasse 27, D 51105, Cologne, Germany
    Diabetologia 52:1732-44. 2009
    ..The aim of this cohort study was to investigate the risk of malignant neoplasms and mortality in patients with diabetes treated either with human insulin or with one of three insulin analogues...
  84. ncbi Systemic lupus erythematosus disease activity index 2000
    Dafna D Gladman
    The University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Ontario, Canada
    J Rheumatol 29:288-91. 2002
    ....
  85. ncbi Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk
    P A van den Brandt
    Department of Epidemiology, Maastricht University, The Netherlands
    Am J Epidemiol 152:514-27. 2000
    ..anthropometric indices and the risk of breast cancer was analyzed using pooled data from seven prospective cohort studies. Together, these cohorts comprise 337,819 women and 4,385 incident invasive breast cancer cases...
  86. pmc Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies
    R Huxley
    The George Institute for International Health, The University of Sydney, PO Box M201, Missenden Road, Sydney NSW 2050, Australia
    Br J Cancer 92:2076-83. 2005
    ..66-1.89), with evidence of heterogeneity across the studies (P=0.002 for case-control and P=0.05 for cohort studies) that was explained, in part, by higher risks being reported by smaller studies and studies that reported ..
  87. ncbi Combination antiretroviral strategies for the treatment of pregnant HIV-1-infected women and prevention of perinatal HIV-1 transmission
    Ellen R Cooper
    Maxwell Finland Laboratory for Infectious Diseases, Boston Medical Center, Boston University School of Medicine, 774 Albany Street, Suite 506, Boston, MA 02118, U S A
    J Acquir Immune Defic Syndr 29:484-94. 2002
    ..The Women and Infants Transmission Study is a prospective natural history study that has been enrolling HIV-1-infected pregnant women and their infants since 1989...
  88. pmc Newly identified genetic risk variants for celiac disease related to the immune response
    Karen A Hunt
    Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, 4 Newark Street, London E1 2AT, UK
    Nat Genet 40:395-402. 2008
    ..Type 1 diabetes and celiac disease share HLA-DQ, IL2-IL21, CCR3 and SH2B3 risk regions. Thus, this extensive genome-wide association follow-up study has identified additional celiac disease risk variants in relevant biological pathways...
  89. ncbi Low-grade systemic inflammation and the development of type 2 diabetes: the atherosclerosis risk in communities study
    Bruce B Duncan
    Graduate Studies Program in Epidemiology, School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
    Diabetes 52:1799-805. 2003
    ..7 (P for linear trend = 0.008). In conclusion, a low-grade inflammation predicts incident type 2 diabetes. The association is absent in smokers and African-Americans...
  90. pmc Adherence to Mediterranean diet and health status: meta-analysis
    Francesco Sofi
    Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    BMJ 337:a1344. 2008
    To systematically review all the prospective cohort studies that have analysed the relation between adherence to a Mediterranean diet, mortality, and incidence of chronic diseases in a primary prevention setting.
  91. pmc Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome
    Harriet C T Groom
    Division of Virology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Retrovirology 7:10. 2010
    ....
  92. pmc MYH9 is associated with nondiabetic end-stage renal disease in African Americans
    W H Linda Kao
    Department of Epidemiology, School of Medicine and Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Nat Genet 40:1185-92. 2008
    ....
  93. ncbi Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis
    Colin N A Palmer
    Population Pharmacogenetics Group, Biomedical Research Centre, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Nat Genet 38:441-6. 2006
    ..These variants also show highly significant association with asthma occurring in the context of atopic dermatitis. This work establishes a key role for impaired skin barrier function in the development of atopic disease...
  94. ncbi Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arch Gen Psychiatry 62:593-602. 2005
    ..Little is known about lifetime prevalence or age of onset of DSM-IV disorders...
  95. ncbi Long-term effects of insulin glargine on the risk of breast cancer
    S Suissa
    Center for Clinical Epidemiology, Lady Davis Research Institute, Jewish General Hospital, 3755 Cote Ste Catherine, Montreal, QC, Canada H3T 1E2
    Diabetologia 54:2254-62. 2011
    ..There have been growing concerns regarding the long-term effects of insulin glargine (A21Gly,B31Arg,B32Arg human insulin) on the risk of breast cancer...
  96. pmc Correcting for mortality among patients lost to follow up on antiretroviral therapy in South Africa: a cohort analysis
    Gilles Van Cutsem
    Medecins Sans Frontieres, Cape Town, South Africa
    PLoS ONE 6:e14684. 2011
    ..We describe LTF before and after correction for mortality in a primary care ART programme with linkages to the national vital registration system...
  97. ncbi Updated definitions of healthy ranges for serum alanine aminotransferase levels
    Daniele Prati
    Centro Trasfusionale e di Immunologia dei Trapianti, Laboratorio di Epidemiologia, Divisione di Ematologia, Istituto di Statistica Medica e Biometria, Cattedra di Gastroenterologia, Milan, Italy
    Ann Intern Med 137:1-10. 2002
    ..Current standards for "normal" ALT level were defined by using populations that included persons with subclinical liver disease...
  98. ncbi Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
    Jerome Galon
    INSERM U 255, Paris, 75006 France Université Paris Descartes Paris 5, Faculte de Medecine, Paris, 75006 France
    Science 313:1960-4. 2006
    ..In situ analysis of tumor-infiltrating immune cells may therefore be a valuable prognostic tool in the treatment of colorectal cancer and possibly other malignancies...
  99. pmc Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts
    Yudi Pawitan
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Breast Cancer Res 7:R953-64. 2005
    ..Breast cancer expression profiling has so far mainly been used to identify women with a poor prognosis as candidates for adjuvant therapy but without demonstrated value for therapy prediction...
  100. ncbi Work stress in the etiology of coronary heart disease--a meta-analysis
    Mika Kivimaki
    Finnish Insitute of Occupational Health, Topeliuksenkatu 41 a A, FI 00250 Helsinki, Finland
    Scand J Work Environ Health 32:431-42. 2006
    ..This study focused on estimating the relative risk of coronary heart disease (CHD) in association with work stress, as indicated by the job-strain model, the effort-reward imbalance model, and the organizational injustice model...

Research Grants69

  1. Prospective studies of cancer etiology and prevention in Shanghai and Singapore
    Jian Min Yuan; Fiscal Year: 2013
    ..follow-up of the 81,501 middle-aged and older Chinese men and women participants of the Shanghai and Singapore cohort studies for another 5 five years, to accrue and validate a substantially increased number of cancer endpoints in order ..
  2. Improving TB Diagnosis in Children with and without HIV in Kenya
    Rinn Song; Fiscal Year: 2013
    ..I will have the opportunity to conduct two prospective cohort studies in collaboration with the Kenya Medical Research Institute/Center for Diseases Control and Prevention Research ..
  3. Latin American Center for Malaria Research and Control
    SOCRATES HERRERA VALENCIA; Fiscal Year: 2013
    ..This investigation includes community based cohort studies (prospective studies), active surveillance using temporal cross-sectional studies, and hospital based passive ..
  4. Endotoxin, the airway transcriptome, and obstructive lung disease
    PEGGY SUE LAI; Fiscal Year: 2013
    ..These studies take advantage of the sound study infrastructure present in two already existing and unique cohort studies, and will provide novel insights into the ways nasal gene expression can be used to understand the effects of ..
  5. Vitamin D and Fish Oil for Autoimmune Disease, Inflammation and Joint Pain
    Karen H Costenbader; Fiscal Year: 2013
    ..Given the NIH-funded VITAL trial and our success with prior large mail-based trials and cohort studies, the proposed trial will furnish either definitive positive or informative null results regarding the central ..
  6. Plasma Lipid Markers and Cancer Risk
    Lu Wang; Fiscal Year: 2013
    ....
  7. Graves'Disease Therapy Risks to Mother and Fetus
    Scott A Rivkees; Fiscal Year: 2013
    ..b>Cohort studies will be performed using large clinical databases, including those of Marketscan (>1...
  8. Dioxins and Male Pubertal Growth and Development
    Russ B Hauser; Fiscal Year: 2013
    ..In boys, there are limited longitudinal cohort studies on the timing and progression of puberty and few studies on the impact of environmental chemicals...
  9. Exercise, Breast Cancer Prevention, and Mechanisms
    Henry J Thompson; Fiscal Year: 2013
    ..Estimates of the affect size ranged from 20% - 80% reduction in risk from the majority of reported cohort studies and 20% - 70% from a number of population-based case-control studies...
  10. Development of New Therapeutics for Pancreatic Cancer Management
    RICHARD JOSEPH PIETRAS; Fiscal Year: 2013
    ..This preclinical work is supported by clinical cohort studies showing that metformin users have a reduced risk of pancreatic cancer;and that metformin use correlates with a ..
  11. Immunology, Inflammation, and Endometriosis
    STACEY ANN MISSMER; Fiscal Year: 2012
    ..Study II, and over 500 within the Black Women's Health Study [unreadable]ongoing, prospective cohort studies that began when 116,000 women were enrolled in 1989 and 59,000 in 1995, respectively...
  12. For Hearing Component in the Hispanic Community Health Study (HCHS)
    Lisa Lavange; Fiscal Year: 2009
    ..Longitudinal cohort studies in Hispanic populations are needed to understand the development of risk factors and disease in these ..
  13. Cerebrovascular Disease and its Consequences in the Strong Study Cohort
    Dedra S Buchwald; Fiscal Year: 2013
    ..Magnetic resonance imaging (MRI) has redefined CBVD in large cohort studies, such as the Cardiovascular Health Study (CHS) and Atherosclerosis Risk in Communities (ARIC)...
  14. A multi-faceted approach to epigenomic profiling in Alzheimer's disorder
    Jonathan Mill; Fiscal Year: 2012
    ..death, and subsequently in a large independent collection of blood DNA samples obtained from ongoing clinical cohort studies. Our goals of identifying a) molecular changes in the brain associated with AD and associated neuropsychiatric ..
  15. Colonic Cytokinetics and Cell Signaling: Dietary Effects
    ROBERT STEPHEN CHAPKIN; Fiscal Year: 2012
    ..between dietary fat and fiber may explain why the chemoprotective effects of fiber are obscured in prospective cohort studies. Therefore, the overall goal of this proposal is to further elucidate how dietary n-3 PUFA and fermentable ..
  16. NAPS2 Continuation Genome Wide Association Study of Pancreatitis
    DAVID CLEMENT WHITCOMB; Fiscal Year: 2011
    ..genotyped controls will also be available for analysis);2) Obtain information from two European pancreatitis cohort studies (n=2850) corresponding to the lead SNPs from our combined discovery cohort analysis (Aim 1) for replication/..
  17. Pulmonary Vascular Changes in Early Chronic Obstructive Pulmonary Disease (COPD)
    R Graham Barr; Fiscal Year: 2011
    ..endothelial function and reduced cardiac output with preserved LV function in early COPD among smokers in two cohort studies, the EMCAP Study and the Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study...
  18. Environmental Determinants of Cognitive Aging in the WHI Memory Study
    Jiu Chiuan Chen; Fiscal Year: 2013
    ..Convincing cohort studies on whether and how ambient air pollution contributes to brain aging and subsequent risk of cognitive ..
  19. Chemoprevention of Prostate Cancer
    SUSAN AUDREY HALL; Fiscal Year: 2012
    ..chemopreventive potential of these currently marketed drugs by conducting retrospective, pharmacoepidemiologic cohort studies of prostate and breast cancer outcomes nested in these databases...
  20. Socioeconomic status and smoking exposure in Appalachia
    Joshua E Muscat; Fiscal Year: 2013
    ..In prospective cohort studies, the associations between low SES and elevated lung cancer risk persist after adjustment for smoking amount ..
  21. Molecular Profiles and Lifestyle Factors in Breast Cancer Prognosis
    Bette J Caan; Fiscal Year: 2013
    ..subtypes and their relationship to breast cancer risk factors and short and long-term prognosis in two ongoing cohort studies of breast cancer survivors (N=4177) being conducted within the Kaiser Permanente of Northern California (KPNC) ..
  22. Dietary Patterns, Diet Quality + Cancer Risk
    Frank B Hu; Fiscal Year: 2012
    ..between new dietary indexes and dietary patterns and risk of breast, colon, and prostate cancer in cohort studies of 121,700 women aged 30-55 years at baseline (1976, the Nurses'Health Study), 11,686 women aged 24-44 ..
  23. Development and validation of a chitin assay for environmental samples
    CHRISTINE ANNE ROGERS; Fiscal Year: 2012
    ..Finally we will use the new chitin assay on archived dust samples from previous cohort studies and will compare chitin content with existing measures of chitin-containing organisms (culturable fungi) and ..
  24. Southern Community Cohort Study
    Wei Zheng; Fiscal Year: 2013
    ..The SCCS thus differs from all other cohort studies in racial composition and socioeconomic disadvantage, and tracks a population possibly at higher cancer risk ..
  25. Modifiable lifestyle-related factors and triple negative breast cancer prognosis
    SARAH JEAN NECHUTA; Fiscal Year: 2013
    ..With the addition of two more ongoing cohort studies, we anticipate a total of approximately 1,550 women diagnosed with invasive TNBC recruited from the United ..
  26. In Vivo Imaging of bcl-2 Expression in Lymphoma
    Michael R Lewis; Fiscal Year: 2012
    ..In aggressive lymphoma, large cohort studies have shown that overexpression of the bcl-2 gene correlates strongly with resistance to radiation and ..
  27. The Effect of Diet and Nutrients on the Progression and Treatment of Prostate Can
    George Thomas; Fiscal Year: 2013
    ..Prospective cohort studies have shown a statistically significant positive association between obesity and the risk of death from PCa...
  28. Identification of Causal Variants at Novel GWAS Loci Associated with Lipid Traits
    DANIEL JAMES RADER; Fiscal Year: 2010
    ..and analytic methods for deep sequencing using next-generation technology;and (4) five population-based cohort studies with baseline lipid measures and longitudinal follow-up for incident CVD...
  29. Reasons for Racial Disparities in Venous Thromboembolism
    NEIL ADRIAN ZAKAI; Fiscal Year: 2010
    ..Dr. S. Judd is an expert on nutritional assessment in cohort studies, and Dr. V. Wadley is an expert on cognitive assessment. Dr. M...
  30. Epidemiologic Studies of Type 2 Diabetes in Normal Weight Adults
    MERCEDES RENEE CARNETHON; Fiscal Year: 2010
    ..Diabetes, Digestive and Kidney Disease), we propose to pool together data from multiple existing longitudinal cohort studies to conduct an epidemiologic study of demographic and clinical characteristics, behavioral factors, and ..
  31. Health benefits of vigorous exercise in middle-aged versus older men and women
    Paul T Williams; Fiscal Year: 2010
    ..Currently, a number of well-designed cohort studies are able to assess the impact of moderately intense physical activity on disease risk...
  32. Biomarkers of Kidney Pathology
    Sushrut S Waikar; Fiscal Year: 2013
    ..investigators and will facilitate multidirectional translation of findings across animal studies, large cohort studies, and the biopsy cohort. Urine, plasma, and DNA samples will be shared with the Consortium for future studies.
  33. The Effects of Lung Transplant on Disability and Health-Related Quality of Life
    Jonathan Paul Singer; Fiscal Year: 2013
    ..This plan also includes one-on-one apprenticeship training in the design and implementation of prospective cohort studies;advanced biostatistics;how to conceptualize and interpret measures of disability, functioning, and HRQL;and ..
  34. Clinical utility of extracellular RNA as marker of kidney disease progression
    Thomas Tuschl; Fiscal Year: 2013
    ..implementation of our research plan we established collaborations with investigators conducting longitudinal cohort studies of CKD...
  35. The natural history of cardiovascular health in U.S. populations
    CHRISTY LEIGH AVERY; Fiscal Year: 2013
    ..transition probabilities will then be merged with results from published intervention and longitudinal cohort studies to calculate race/ethnic- and sex- specific reductions in CVD associated with interventions that increase the ..
  36. Effectiveness of ICP Monitoring in Pediatric Traumatic Brain Injury
    TELLEN BENNETT; Fiscal Year: 2013
    ..This proposal will allow Dr. Bennett to develop skills in probabilistic database linkage, prospective cohort studies, propensity methods, multiple imputations, and mixed models. Drs. Mike Dean and Heather Keenan, Dr...
  37. Prospective Study of Restless Leg Syndrome
    Xiang Gao; Fiscal Year: 2011
    ..However, the etiology of RLS remains unknown. Large, well-characterized cohort studies with validated assessment of lifestyle factors could provide critical information and lead to new approaches ..
  38. Validity of Diet and Activity Measures in Men
    Meir Stampfer; Fiscal Year: 2013
    ..study will provide quantitative data on the validity of the methods that have been used in cohort studies to measure diet and physical activity...
  39. Mid Career Award in Patient Oriented Pelvic Floor Research
    Holly E Richter; Fiscal Year: 2013
    ..it will provide valuable time to continue to mentor residents and fellows with ongoing trials and cohort studies 2) continue her productive activities and capabilities as a mentor and facilitator of training of new ..
  40. Direct IL-4 and IL-13 effects on pulmonary smooth muscle in allergic airway disea
    FRED DOUGLASS FINKELMAN; Fiscal Year: 2010
    ..Proposed studies with a mouse model in which airway hyperresponsiveness is induced solely by direct IL-4 and IL-13 effects on smooth muscle should help to elucidate these mechanisms and may reveal new approaches for asthma therapy. ..
  41. NICHD Cooperative Multicenter Neonatal Research Network
    Abbot R Laptook; Fiscal Year: 2013
    ..highest risk infants, 3) to evaluate the epidemiology of specific morbidities using prospective observational cohort studies, 4) to evaluate new diagnostic tests that could not be done readily in a single center, and 5) to generate new ..
  42. Cumulative Stress and CVD Risk in Middle-Aged and Older Women
    Michelle A Albert; Fiscal Year: 2013
    ..Given our success with WHS and other mail-based clinical trials and cohort studies, as well as the evidence from our preliminary stress and socioeconomic related data in this population, we ..
  43. Molecular, Genetic &Physiological Studies of Calcium-activated Chloride Channels
    Lily Y Jan; Fiscal Year: 2013
    ..We will also use a combination of approaches to determine the CaCC stoichiometry - an important question for better appreciation of CaCC function and regulation, and the diversity of CaCCs. ..
  44. Determinants and Cardiovascular Consequences of Diabetes in Older Adults
    Susan J Zieman; Fiscal Year: 2012
    ..Few population-based cohort studies have sufficient numbers of participants, duration, stored specimens, measures of comorbidity, and confirmed ..
  45. Genetic and Environmental Risk Factors for Venous Thromboembolism
    Christopher Kabrhel; Fiscal Year: 2013
    ..NHS I&II and HPFS are ongoing prospective cohort studies of 121,700 and 116,686 female nurses, and 51,529 male health professionals...
  46. Cardiovascular and Prostatic Safety of Testosterone Therapy in Aging Males
    Stephen K Van Den Eeden; Fiscal Year: 2013
    ....
  47. Neighborhood Characteristics &Diabetes Incidence in Multiethnic Cohort Study
    KA apos IMI A SINCLAIR; Fiscal Year: 2013
    ..There are currently three cohort studies in the Epidemiology Program, including the Multiethnic Cohort Study. A GIS workgroup, of which Dr...
  48. RANDOMIZED TRIAL: MATERNAL VITAMIN D SUPPLEMENTATION TO PREVENT CHILDHOOD ASTHMA
    Robert Strunk; Fiscal Year: 2013
    ..We have observational data from two independent birth cohort studies that higher maternal intakes of vitamin D during pregnancy are each independently associated with a 50% ..
  49. RANDOMIZED TRIAL: MATERNAL VITAMIN D SUPPLEMENTATION TO PREVENT CHILDHOOD ASTHMA
    Scott T Weiss; Fiscal Year: 2013
    ..We have observational data from two independent birth cohort studies that higher maternal intakes of vitamin D during pregnancy are each independently associated with a 50% ..
  50. Traffic and Respiratory Health
    Brian P Leaderer; Fiscal Year: 2013
    ..Between 1994 and 2000, over 1,100 children and 2,300 women participated in our prospective cohort studies of respiratory health conducted in Connecticut and central Massachusetts, a region including areas that have ..
  51. Empirical eating disorder classification and validation using prospective studies
    Nadia Micali; Fiscal Year: 2013
    ..We propose to collect additional data on eating disorders and treatment from two ongoing cohort studies, the Growing Up Today Study (GUTS) in the United States and the Avon Longitudinal Study of Parents and ..
  52. Lipoproteins and PEDF in the Vascular Complications of Diabetes
    Timothy J Lyons; Fiscal Year: 2010
    ..First, (in the cohort studies) we will define the role of lipoprotein subclasses defined by nuclear magnetic resonance (NMR) as markers for ..
  53. Mucosal immune response of the anus in women to HPV, intercourse, smoking and OCs
    ANNA BARBARA NONE MOSCICKI; Fiscal Year: 2010
    ..pathogens as well as trauma induced by anal intercourse, 3) there has been a lack of techniques suitable to cohort studies to study immune parameters and 4) accessing tissue and fluids in longitudinal cohorts is often difficult...
  54. Predicting naturally acquired humoral immunity against malaria
    PHILIP LOUIS FELGNER; Fiscal Year: 2013
    ..Craig Venter Institute) to perform genotyping of targeted genomic regions of 700 individuals in one of the cohort studies as well as genome-wide transcription profiling (by RNA-seq...
  55. PREMENOPAUSAL HORMONE LEVELS AND RISK OF BREAST CANCER
    Susan E Hankinson; Fiscal Year: 2011
    ..The NHSII is one of a few cohort studies that provides an ideal context in which to investigate these relationships...
  56. The Predictors and Long-Term Trajectory of Poststroke Cognitive Decline
    Deborah Levine; Fiscal Year: 2013
    ..This project will combine data from 2 leading prospective stroke cohort studies in the US: 1) a large, geographically dispersed, race- and gender-balanced cohort of middle-aged and older ..
  57. VITamin D and omegA-3 triaL (VITAL)
    JOANN ELISABETH MANSON; Fiscal Year: 2013
    ..Given our success with prior mail-based large simple trials and cohort studies, as well as results of a pilot study in the intended source population, we believe the trial will be able to ..
  58. Effect of Nutrition, Immunity, and Vaccines on Pediatric Enteric Infections
    Juan S Leon; Fiscal Year: 2013
    ..He will also acquire mentored field experience in the design and execution of prospective cohort studies. He will be trained, in Aim 3, at the Rotavirus Surveillance Vaccine Program in Bolivia, by recruiting and ..
  59. Pooling of Prospective Studies of Diet, Lifestyle and ALS
    EILIS O'REILLY; Fiscal Year: 2013
    ..Project of Prospective Studies of Diet and Cancer (Cancer Pooling Project), an international consortium of 28 cohort studies. A number of risk factors for sporadic ALS have been examined epidemiologically, mainly in retrospective case-..
  60. Construction of a Dual Function Primate Facility: ABSL3 and Transplant Medicine
    Stuart M Zola; Fiscal Year: 2010
    ....
  61. Epigenetic Events and Colorectal Cancer Epidemiology
    Shuji Ogino; Fiscal Year: 2013
    ..For that purpose, we will utilize the resources of two large prospective cohort studies, the Nurses'Health Study (NHS) and the Health Professionals Follow-up Study (HPFS)...
  62. Mineralization Gene Variants: Biochemical Implications and Associations with BMD
    Carrie M Nielson; Fiscal Year: 2013
    ..and University of Washington (Weir), as well as the international team of investigators on the MrOS and SOF cohort studies of musculoskeletal outcomes...
  63. Early life anthropometry, IGF pathway polymorphisms, and colorectal cancer risk
    Esther Wei; Fiscal Year: 2010
    ..Several early-life anthropometric measures were previously collected in the two large Harvard cohort studies, the Nurses'Health Study (NHS) (n=121,700 women aged 35-50) and the Health Professionals Follow-up Study (..
  64. EFFECTS OF AMBIENT AIR POLLUTANTS ON ANNUAL MORTALITY
    George Thurston; Fiscal Year: 2001
    ..Two prospective cohort studies (Harvard 6-cities and American Cancer Society) showed significant excess annual total, cardiopulmonary, and ..
  65. DIARRHEAL DISEASE STUDY
    Roger Shapiro; Fiscal Year: 2004
    ..issues; he established a diarrheal surveillance system in rural western Kenya, and performed case-control and cohort studies in Kenya and Argentina...
  66. Physical Activity and Diet in the Prevention of Obesity in Men and Women
    Howard D Sesso; Fiscal Year: 2010
    ..in Obesity) and seeks to develop incident obesity as a new endpoint within two large existing prospective cohort studies of men and women...
  67. SIGNIFICANCE OF GGT EXPRESSION IN TUMORS
    MARIE HANIGAN; Fiscal Year: 2009
    ..However, multiple, large cohort studies over the past thirty years have shown that patients with hepatocellular carcinoma (HCC) have tumor-specific ..
  68. Surveillance for Hepatocellular Carcinoma among HCV-infected Veterans
    Hashem El Serag; Fiscal Year: 2009
    ..One randomized controlled trial and several cohort studies have indicated that HCC surveillance is associated with significantly improved survival...
  69. Accuracy of Physical Activity Measures in Cancer Studies
    Barbara Sternfeld; Fiscal Year: 2009
    ..self administered physical activity (PA) questionnaires used to assess recent activity in two on-going cancer cohort studies (Life After Cancer Epidemiology Study, funded by the NCI, and the California Men's Health Study, funded ..