cross over studies

Summary

Summary: Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)

Top Publications

  1. ncbi Inhibition of food intake in obese subjects by peptide YY3-36
    Rachel L Batterham
    Department of Metabolic Medicine, Imperial College Faculty of Medicine at Hammersmith Campus, Du Cane Rd, London W12 0NN, United Kingdom
    N Engl J Med 349:941-8. 2003
  2. ncbi Ghrelin enhances appetite and increases food intake in humans
    A M Wren
    Endocrine Unit, Imperial College School of Medicine, Hammersmith Hospital, London W12 ONN, United Kingdom
    J Clin Endocrinol Metab 86:5992. 2001
  3. ncbi Case-crossover analyses of air pollution exposure data: referent selection strategies and their implications for bias
    Holly Janes
    Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA
    Epidemiology 16:717-26. 2005
  4. ncbi Phase III study of letrozole versus tamoxifen as first-line therapy of advanced breast cancer in postmenopausal women: analysis of survival and update of efficacy from the International Letrozole Breast Cancer Group
    Henning Mouridsen
    Rigshospitalet, Copenhagen, Denmark
    J Clin Oncol 21:2101-9. 2003
  5. ncbi Cereal fiber improves whole-body insulin sensitivity in overweight and obese women
    Martin O Weickert
    Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal 14558, Germany
    Diabetes Care 29:775-80. 2006
  6. ncbi Prior short-term consumption of resistant starch enhances postprandial insulin sensitivity in healthy subjects
    M D Robertson
    Oxford Lipid Metabolism Group, OCDEM, Churchill Hospital, Oxford, UK
    Diabetologia 46:659-65. 2003
  7. ncbi Transient memory impairment after acute dose of 75mg 3.4-Methylene-dioxymethamphetamine
    Kim P C Kuypers
    Experimental Psychopharmacology Unit, Department of Neurocognition, Faculty of Psychology, Maastricht University, Maastricht, The Netherlands
    J Psychopharmacol 19:633-9. 2005
  8. ncbi Whole-grain wheat breakfast cereal has a prebiotic effect on the human gut microbiota: a double-blind, placebo-controlled, crossover study
    Adele Costabile
    Department of Food Biosciences, The School of Chemistry, Food Biosciences, and Pharmacy, University of Reading, Reading RG6 6AP UK
    Br J Nutr 99:110-20. 2008
  9. ncbi Neural and behavioral responses to tryptophan depletion in unmedicated patients with remitted major depressive disorder and controls
    Alexander Neumeister
    Section on Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892 2670, USA
    Arch Gen Psychiatry 61:765-73. 2004
  10. ncbi Acute dopamine D(1) and D(2) receptor stimulation does not modulate mismatch negativity (MMN) in healthy human subjects
    Sumie Leung
    Biological Psychiatry Research Unit, Brain Sciences Institute, Faculty of Life and Social Sciences, Swinburne University of Technology, Melbourne, Australia
    Psychopharmacology (Berl) 194:443-51. 2007

Detail Information

Publications358 found, 100 shown here

  1. ncbi Inhibition of food intake in obese subjects by peptide YY3-36
    Rachel L Batterham
    Department of Metabolic Medicine, Imperial College Faculty of Medicine at Hammersmith Campus, Du Cane Rd, London W12 0NN, United Kingdom
    N Engl J Med 349:941-8. 2003
    ..However, in obesity there is a marked resistance to the action of leptin, which greatly limits its therapeutic effectiveness. We investigated whether obese subjects were also resistant to the anorectic effects of PYY...
  2. ncbi Ghrelin enhances appetite and increases food intake in humans
    A M Wren
    Endocrine Unit, Imperial College School of Medicine, Hammersmith Hospital, London W12 ONN, United Kingdom
    J Clin Endocrinol Metab 86:5992. 2001
    ..Ghrelin is the first circulating hormone demonstrated to stimulate food intake in man. Endogenous ghrelin is a potentially important new regulator of the complex systems controlling food intake and body weight...
  3. ncbi Case-crossover analyses of air pollution exposure data: referent selection strategies and their implications for bias
    Holly Janes
    Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA
    Epidemiology 16:717-26. 2005
    ....
  4. ncbi Phase III study of letrozole versus tamoxifen as first-line therapy of advanced breast cancer in postmenopausal women: analysis of survival and update of efficacy from the International Letrozole Breast Cancer Group
    Henning Mouridsen
    Rigshospitalet, Copenhagen, Denmark
    J Clin Oncol 21:2101-9. 2003
    ..To analyze overall survival (OS) and update efficacy data for letrozole versus tamoxifen as first-line therapy in postmenopausal women with locally advanced or metastatic breast cancer...
  5. ncbi Cereal fiber improves whole-body insulin sensitivity in overweight and obese women
    Martin O Weickert
    Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal 14558, Germany
    Diabetes Care 29:775-80. 2006
    ..The pathogenic background of this phenomenon is unknown. Based on recent findings, we hypothesized that intake of purified insoluble oat fiber may improve whole-body insulin sensitivity...
  6. ncbi Prior short-term consumption of resistant starch enhances postprandial insulin sensitivity in healthy subjects
    M D Robertson
    Oxford Lipid Metabolism Group, OCDEM, Churchill Hospital, Oxford, UK
    Diabetologia 46:659-65. 2003
    ..The aim of this study was to assess whether acute changes in the insoluble-fibre (resistant starch) content of the diet would have effects on postprandial carbohydrate and lipid handling...
  7. ncbi Transient memory impairment after acute dose of 75mg 3.4-Methylene-dioxymethamphetamine
    Kim P C Kuypers
    Experimental Psychopharmacology Unit, Department of Neurocognition, Faculty of Psychology, Maastricht University, Maastricht, The Netherlands
    J Psychopharmacol 19:633-9. 2005
    ..Methylphenidate did not affect memory or mood at any time of testing. A single dose of MDMA produces transient memory impairment...
  8. ncbi Whole-grain wheat breakfast cereal has a prebiotic effect on the human gut microbiota: a double-blind, placebo-controlled, crossover study
    Adele Costabile
    Department of Food Biosciences, The School of Chemistry, Food Biosciences, and Pharmacy, University of Reading, Reading RG6 6AP UK
    Br J Nutr 99:110-20. 2008
    ..Daily consumption of WG wheat exerted a pronounced prebiotic effect on the human gut microbiota composition. This prebiotic activity may contribute towards the beneficial physiological effects of WG wheat...
  9. ncbi Neural and behavioral responses to tryptophan depletion in unmedicated patients with remitted major depressive disorder and controls
    Alexander Neumeister
    Section on Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892 2670, USA
    Arch Gen Psychiatry 61:765-73. 2004
    ....
  10. ncbi Acute dopamine D(1) and D(2) receptor stimulation does not modulate mismatch negativity (MMN) in healthy human subjects
    Sumie Leung
    Biological Psychiatry Research Unit, Brain Sciences Institute, Faculty of Life and Social Sciences, Swinburne University of Technology, Melbourne, Australia
    Psychopharmacology (Berl) 194:443-51. 2007
    ....
  11. ncbi Long-term effects of repetitive transcranial magnetic stimulation (rTMS) in patients with chronic tinnitus
    Tobias Kleinjung
    Department of Otorhinolaryngology, University of Regensburg, Germany
    Otolaryngol Head Neck Surg 132:566-9. 2005
    ..Recent studies demonstrated focal brain activation in the auditory cortex of patients with chronic tinnitus. Low-frequency repetitive transcranial magnetic stimulation (rTMS) is able to reduce cortical hyperexcitability...
  12. ncbi Effects of exercise on gut peptides, energy intake and appetite
    Catia Martins
    School of Biomedical and Molecular Sciences, University of Surrey, Guildford, UK
    J Endocrinol 193:251-8. 2007
    ..This impact on appetite and subsequent energy homeostasis was not explained by changes in postprandial levels of ghrelin; however, 'exercise-induced anorexia' may potentially be linked to increased PYY, GLP-1 and PP levels...
  13. ncbi Short-term administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in blood pressure in healthy persons
    Davide Grassi
    Department of Internal Medicine and Public Health, University of L Aquila, L Aquila, Italy
    Am J Clin Nutr 81:611-4. 2005
    ..In turn, nitric oxide bioavailability deeply influences insulin-stimulated glucose uptake and vascular tone. Thus, flavanols may also exert positive metabolic and pressor effects...
  14. ncbi Allopurinol improves endothelial dysfunction in chronic heart failure
    Colin A J Farquharson
    Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Dundee, UK
    Circulation 106:221-6. 2002
    ..Xanthine oxidase produces oxidative stress and therefore we examined whether allopurinol improved endothelial dysfunction in chronic heart failure...
  15. pmc Design, analysis, and presentation of crossover trials
    Edward J Mills
    Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada
    Trials 10:27. 2009
    ..Although crossover trials enjoy wide use, standards for analysis and reporting have not been established. We reviewed methodological aspects and quality of reporting in a representative sample of published crossover trials...
  16. ncbi Treatment of restless legs syndrome with gabapentin: a double-blind, cross-over study
    D Garcia-Borreguero
    Department of Neurology, Fundacion Jimenez Diaz, Madrid, Spain
    Neurology 59:1573-9. 2002
    ..To assess the effects of gabapentin on sensory and motor symptoms in patients with restless legs syndrome (RLS)...
  17. ncbi Exposure to traffic and the onset of myocardial infarction
    Annette Peters
    Institute of Epidemiology, GSF National Research Center for Environment and Health, Neuherberg, Germany
    N Engl J Med 351:1721-30. 2004
    ..This study was designed to assess whether exposure to traffic can trigger myocardial infarction...
  18. ncbi Effects of dextroamphetamine on cognitive performance and cortical activation
    V S Mattay
    Clinical Brain Disorders Branch, Intramural Research Program, Laboratory of Diagnostic Radiology Research, Office of Intramural Research, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland, 20892, USA
    Neuroimage 12:268-75. 2000
    ..These heterogeneic effects of dextroamphetamine may be explained by genetic variations that interact with the effects of dextroamphetamine...
  19. ncbi A single dose of the selective serotonin reuptake inhibitor citalopram exacerbates anxiety in humans: a fear-potentiated startle study
    Christian Grillon
    Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH, Bethesda, MD 20892 2670, USA
    Neuropsychopharmacology 32:225-31. 2007
    ..These results indicate that a single dose of citalopram is not anxiogenic in itself, but can exacerbate the expression of fear and anxiety...
  20. ncbi Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism
    Gisele Pickering
    Institut National de la Sante et de la Recherche Medicale, Centre d Investigation Clinique 501, Centre Hospitalier Universitaire Clermont Ferrand, France
    Clin Pharmacol Ther 79:371-8. 2006
    ..The aim of this study was to confirm these findings in humans...
  21. ncbi Synthetic exendin-4 (exenatide) significantly reduces postprandial and fasting plasma glucose in subjects with type 2 diabetes
    Orville G Kolterman
    Amylin Pharmaceuticals, Inc, San Diego, California 92121, USA
    J Clin Endocrinol Metab 88:3082-9. 2003
    ..This robust antidiabetic effect warrants further evaluation of AC2993...
  22. ncbi Transcranial direct current stimulation during sleep improves declarative memory
    Lisa Marshall
    Institute of Neuroendocrinology H23a, University of Lubeck, 23538 Lubeck, Germany
    J Neurosci 24:9985-92. 2004
    ..Shifts in extracellular ionic concentration in frontocortical tissue (expressed as negative DC potentials during SWS) may facilitate sleep-dependent consolidation of declarative memories...
  23. ncbi Referent selection in case-crossover analyses of acute health effects of air pollution
    D Levy
    Department of Epidemiology, University of Washington, Seattle 98195-7232, USA
    Epidemiology 12:186-92. 2001
    ..In addition, conditional logistic regression analysis is not strictly valid for some case-crossover designs, introducing further bias...
  24. ncbi Effect of a high-protein breakfast on the postprandial ghrelin response
    Wendy A M Blom
    TNO Quality of Life, Zeist, Netherlands
    Am J Clin Nutr 83:211-20. 2006
    ..The most satiating macronutrient appears to be dietary protein. Few studies have investigated the effects of dietary protein on ghrelin secretion in humans...
  25. ncbi Walnuts and fatty fish influence different serum lipid fractions in normal to mildly hyperlipidemic individuals: a randomized controlled study
    Sujatha Rajaram
    Department of Nutrition, School of Public Health, Loma Linda University, Loma Linda, CA, USA
    Am J Clin Nutr 89:1657S-1663S. 2009
    ..Increased consumption of n-3 (omega-3) fatty acids decreases the incidence of coronary heart disease (CHD)...
  26. ncbi Crossover trial of analgesic efficacy of glucose and pacifier in very preterm neonates during subcutaneous injections
    Ricardo Carbajal
    Poissy Neonatal Intensive Care Unit, Poissy Saint Germain Hospital, Poissy, France
    Pediatrics 110:389-93. 2002
    ....
  27. ncbi Case-crossover design in air pollution epidemiology
    J J K Jaakkola
    Institute of Occupational Health, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Eur Respir J Suppl 40:81s-85s. 2003
    ..Case-crossover design is amenable for studying the effects of varying short-term air pollution exposure on health outcomes with an abrupt onset, such as myocardial infarction or asthma attack...
  28. ncbi Hand-rubbing with an aqueous alcoholic solution vs traditional surgical hand-scrubbing and 30-day surgical site infection rates: a randomized equivalence study
    Jean Jacques Parienti
    Departments of Infectious Diseases and Intensive Care Unit, Côte de Nacre University Hospital Centre, 14 033 Caen Cedex, France
    JAMA 288:722-7. 2002
    ..Clinical studies comparing the risk of nosocomial infection after different hand antisepsis protocols are scarce...
  29. ncbi Constant intravenous ghrelin infusion in healthy young men: clinical pharmacokinetics and metabolic effects
    Esben Thyssen Vestergaard
    Medical Department M Endocrinology and Diabetes, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Am J Physiol Endocrinol Metab 292:E1829-36. 2007
    ....
  30. ncbi Pharmacokinetic and pharmacodynamic profile of new biosimilar filgrastim XM02 equivalent to marketed filgrastim Neupogen: single-blind, randomized, crossover trial
    Heinz Lubenau
    BioGeneriX AG, Mannheim, Germany
    BioDrugs 23:43-51. 2009
    ..This study was conducted to compare the pharmacokinetic and pharmacodynamic characteristics of the new biosimilar filgrastim XM02 with the marketed filgrastim (Neupogen)...
  31. ncbi Hydrolysed protein accelerates the gastrointestinal transport of formula in preterm infants
    W A Mihatsch
    Department of Pediatrics, University of Ulm, Germany
    Acta Paediatr 90:196-8. 2001
    ..Conclusion: The hydrolysate protein formula accelerated gastrointestinal transit of milk and stools, but whether hydrolysate formulas enable a more rapid establishment of full enteral feeding in preterm infants needs to be investigated...
  32. ncbi Docosahexaenoic acid restores endothelial function in children with hyperlipidemia: results from the EARLY study
    M M Engler
    University of California, San Francisco, San Francisco, CA 94143 0610, USA
    Int J Clin Pharmacol Ther 42:672-9. 2004
    ....
  33. ncbi Pharmacodynamic and pharmacokinetic effects of TPA023, a GABA(A) alpha(2,3) subtype-selective agonist, compared to lorazepam and placebo in healthy volunteers
    S L de Haas
    Centre for Human Drug Research, Leiden, The Netherlands
    J Psychopharmacol 21:374-83. 2007
    ..Contrary to lorazepam, TPA023 caused no detectable memory impairment or postural imbalance. These differences reflect the selectivity of TPA023 for different GABA(A) receptor subtypes...
  34. ncbi Involvement of inferior parietal lobules in prospective memory impairment during acute MDMA (ecstasy) intoxication: an event-related fMRI study
    Johannes G Ramaekers
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Neuropsychopharmacology 34:1641-8. 2009
    ..It is concluded that the loss of deactivation in inferior parietal lobules may account for increments in memory failures observed during MDMA intoxication...
  35. pmc A double dissociation in the roles of serotonin and mood in healthy subjects
    Oliver J Robinson
    Department of Psychiatry and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom
    Biol Psychiatry 65:89-92. 2009
    ..We attempted to disentangle the influence of affect on cognition by examining the effect of manipulating both serotonin (via acute tryptophan depletion [ATD]) and mood on established hot and cold cognitive tasks...
  36. ncbi Efficiency of the cross-over design: an empirical estimation
    Raquel Garcia
    Institut Municipal d Investigacio Medica, Barcelona, Spain
    Stat Med 23:3773-80. 2004
    ....
  37. ncbi (1)H NMR metabolite profiling of feces as a tool to assess the impact of nutrition on the human microbiome
    Doris M Jacobs
    Unilever R and D, Vlaardingen, The Netherlands
    NMR Biomed 21:615-26. 2008
    ....
  38. ncbi Recombinant human lactoferrin ingestion attenuates indomethacin-induced enteropathy in vivo in healthy volunteers
    F J Troost
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands
    Eur J Clin Nutr 57:1579-85. 2003
    ....
  39. ncbi The effect of beta-glucan on the glycemic and insulin index
    H Mäkeläinen
    Functional Foods Forum, University of Turku, Helsinki, Finland
    Eur J Clin Nutr 61:779-85. 2007
    ..To determine the effects of oat products with increasing beta-glucan content on the glycemic (GI) and insulin indexes (II) of oat products, and to establish the effect of physical properties of beta-glucan on these physiological responses...
  40. ncbi Acute dose of MDMA (75 mg) impairs spatial memory for location but leaves contextual processing of visuospatial information unaffected
    Kim P C Kuypers
    Experimental Psychopharmacology Unit, Department of Neurocognition, Faculty of Psychology, Maastricht University, Maastricht, The Netherlands
    Psychopharmacology (Berl) 189:557-63. 2007
    ..Two factors may have confounded results in abstinent users: memory task characteristics and polydrug use...
  41. ncbi The effect of caffeine, green tea and tyrosine on thermogenesis and energy intake
    A Belza
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark
    Eur J Clin Nutr 63:57-64. 2009
    ..To investigate the effect of three different food ingredients tyrosine, green tea extract (GTE) and caffeine on resting metabolic rate and haemodynamics, and on ad libitum energy intake (EI) and appetite...
  42. ncbi Methylphenidate bioavailability from two extended-release formulations
    M A Gonzalez
    GloboMax Américas, Weston, FL, USA
    Int J Clin Pharmacol Ther 40:175-84. 2002
    ....
  43. ncbi Improved short-term spatial memory but impaired reversal learning following the dopamine D(2) agonist bromocriptine in human volunteers
    M A Mehta
    Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Addenbrooke s Hospital, UK
    Psychopharmacology (Berl) 159:10-20. 2001
    ..Studies in humans of cognitive effects of dopaminergic drugs have largely focused on tasks of working memory, with a few studies also examining executive function...
  44. ncbi Opposing roles for dopamine and serotonin in the modulation of human spatial working memory functions
    M Luciana
    Department of Psychology, University of Oregon, Eugene, USA
    Cereb Cortex 8:218-26. 1998
    ....
  45. pmc Pharmacokinetics and tolerability of artesunate and amodiaquine alone and in combination in healthy volunteers
    Catherine Orrell
    Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Anzio Road, Observatory, Cape Town, 7925, South Africa
    Eur J Clin Pharmacol 64:683-90. 2008
    ..As no pharmacokinetic data on this combination have been published to date, we investigated its pharmacokinetic interactions and tolerability in healthy volunteers in Africa...
  46. ncbi Lung deposition of hydrofluoroalkane-134a beclomethasone is greater than that of chlorofluorocarbon fluticasone and chlorofluorocarbon beclomethasone : a cross-over study in healthy volunteers
    Chet L Leach
    3M Pharmaceuticals, St Paul, MN, USA
    Chest 122:510-6. 2002
    ..To compare the lung deposition of radiolabeled hydrofluoroalkane-134a beclomethasone dipropionate (HFA-BDP) with chlorofluorocarbon fluticasone propionate (CFC-FP) and chlorofluorocarbon beclomethasone (CFC-BDP)...
  47. ncbi Should we use a case-crossover design?
    M Maclure
    Epidemiology Department, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Annu Rev Public Health 21:193-221. 2000
    ....
  48. ncbi A walnut diet improves endothelial function in hypercholesterolemic subjects: a randomized crossover trial
    Emilio Ros
    Lipid Clinic at the Endocrinology and Nutrition Service, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Barcelona, Spain
    Circulation 109:1609-14. 2004
    ..Endothelial dysfunction is associated with CAD and its risk factors and is reversed by antioxidants and marine n-3 fatty acids. Walnuts are a rich source of both antioxidants and alpha-linolenic acid, a plant n-3 fatty acid...
  49. ncbi A case-crossover analysis of particulate matter air pollution and out-of-hospital primary cardiac arrest
    D Levy
    Department of Epidemiology, University of Washington, Seattle 98195-7232, USA
    Epidemiology 12:193-9. 2001
    ..The null results of this study may result from several factors, including the highly selected nature of this case series and the relatively low particulate matter levels in the Seattle metropolitan area...
  50. ncbi Glycemic responses of oat bran products in type 2 diabetic patients
    N Tapola
    Oy Foodfiles Ltd, Kuopio, Finland
    Nutr Metab Cardiovasc Dis 15:255-61. 2005
    ..In addition, we investigated the effects of oat bran flour on postprandial glucose response following an oral glucose load...
  51. pmc Effects of dietary sodium and hydrochlorothiazide on the antiproteinuric efficacy of losartan
    Liffert Vogt
    Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
    J Am Soc Nephrol 19:999-1007. 2008
    ..Combining these interventions in sodium status is an effective method to maximize the antiproteinuric efficacy of RAAS blockade...
  52. ncbi Diesel exhaust inhalation causes vascular dysfunction and impaired endogenous fibrinolysis
    Nicholas L Mills
    Centre for Cardiovascular Science, Edinburgh University, Edinburgh, Scotland
    Circulation 112:3930-6. 2005
    ..The study aim was to investigate the effects of diesel exhaust inhalation on vascular and endothelial function in humans...
  53. ncbi Oral L-arginine improves endothelial function in healthy individuals older than 70 years
    Stefanie M Bode-Boger
    Institute of Clinical Pharmacology, University Hospital, Otto von Guericke University, Magdeburg, Germany
    Vasc Med 8:77-81. 2003
    ..05). We conclude that in healthy very old age endothelial function is impaired and may be improved by oral L-arginine supplementation, probably due to normalization of the L-arginine/ADMA ratio...
  54. ncbi Lack of effect of acupuncture on electromyographic (EMG) activity--a randomised controlled trial in healthy volunteers
    Liz Tough
    Peninsula Medical School, Universiy of Plymouth, Plymouth, UK
    Acupunct Med 24:55-60. 2006
    ..This study's aim was to examine the immediate effects of acupuncture on the EMG activity of the common wrist extensor muscles...
  55. pmc Reductions in portion size and energy density of foods are additive and lead to sustained decreases in energy intake
    Barbara J Rolls
    Nutrition Department, The Pennsylvania State University, University Park, PA 16802 6501, USA
    Am J Clin Nutr 83:11-7. 2006
    ..When the portion size and energy density (in kcal/g) of a food are varied simultaneously in a single meal, each influences energy intake independently...
  56. ncbi Pharmacological dissection of the paradoxical pain induced by a thermal grill
    Delphine Kern
    INSERM U 792, Centre d Evaluation et de Traitement de la Douleur, CHU Ambroise Pare, 9, avenue Charles de Gaulle, Boulogne Billancourt F 92100, France
    Pain 135:291-9. 2008
    ..This paradoxical pain, which involves the glutamatergic systems, acting through the NMDA receptors, but not the tonic endogenous opioids systems, might share some mechanisms with pathological pain...
  57. ncbi Evidence for an independent and cumulative effect of postprandial hypertriglyceridemia and hyperglycemia on endothelial dysfunction and oxidative stress generation: effects of short- and long-term simvastatin treatment
    Antonio Ceriello
    Department of Pathology and Medicine, Experimental and Clinical, Chair of Internal Medicine, University of Udine, Udine, Italy
    Circulation 106:1211-8. 2002
    ..Evidence suggests that postprandial hypertriglyceridemia and hyperglycemia induce endothelial dysfunction through oxidative stress; however, the distinct role of these two factors is a matter of debate...
  58. ncbi Increased particulate air pollution and the triggering of myocardial infarction
    A Peters
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Circulation 103:2810-5. 2001
    ..Further studies in other locations are needed to clarify the importance of this potentially preventable trigger of MI...
  59. pmc Effects of repetitive transcranial magnetic stimulation on chronic tinnitus: a randomised, crossover, double blind, placebo controlled study
    Simone Rossi
    Dipartimento di Neuroscienze, Sezione Neurologia, Brain Stimulation and Evoked Potentials Lab, Universita di Siena, Policlinico Le Scotte, Viale Bracci, I 53100, Siena, Italy
    J Neurol Neurosurg Psychiatry 78:857-63. 2007
    ..Moreover, it may be difficult to distinguish actual repetitive transcranial magnetic stimulation (rTMS) induced clinical benefits beyond placebo effects in neuropsychiatric patients...
  60. ncbi Characterization of a 7% carbon dioxide (CO2) inhalation paradigm to evoke anxiety symptoms in healthy subjects
    Stefano Zanone Poma
    Psychiatry Centre of Excellence for Drug Discovery, Medical Research Centre, GlaxoSmithKline, Verona, Italy
    J Psychopharmacol 19:494-503. 2005
    ..Good test-retest repeatability was observed in 'responders'. These data indicate that the test can be suitable for testing putative anti-panic or anxiolytic drugs in clinical studies using a within subject, crossover design...
  61. ncbi Cocoa reduces blood pressure and insulin resistance and improves endothelium-dependent vasodilation in hypertensives
    Davide Grassi
    Dipartimento Internal Medicine and Public Health, University of L Aquila, Piazzale Salvatore Tommasi 1, 67100 Coppito, L Aquila, Italy
    Hypertension 46:398-405. 2005
    ..These results suggest that, while balancing total calorie intake, flavanols from cocoa products may provide some cardiovascular benefit if included as part of a healthy diet for patients with EH...
  62. ncbi Influence of letrozole and anastrozole on total body aromatization and plasma estrogen levels in postmenopausal breast cancer patients evaluated in a randomized, cross-over study
    Jurgen Geisler
    Department of Oncology, Haukeland University Hospital, Bergen, Norway
    J Clin Oncol 20:751-7. 2002
    ..To compare the effects of the two novel, potent, nonsteroidal aromatase inhibitors anastrozole and letrozole on total-body aromatization and plasma estrogen levels...
  63. ncbi Moderate alcohol consumption lowers risk factors for cardiovascular disease in postmenopausal women fed a controlled diet
    David J Baer
    US Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Center, Beltsville, MD 20705, USA
    Am J Clin Nutr 75:593-9. 2002
    ..Moderate alcohol consumption (1-2 drinks/d) may decrease cardiovascular disease risk in postmenopausal women by improving lipid profiles...
  64. ncbi Evidence of a role of tumor necrosis factor alpha in refractory asthma
    Mike A Berry
    Institute for Lung Health, University Hospital of Leicester National Health Service Trust, Glenfield Hospital, Leicester, United Kingdom
    N Engl J Med 354:697-708. 2006
    ..The development of tumor necrosis factor alpha (TNF-alpha) antagonists has made it feasible to investigate the role of this cytokine in refractory asthma...
  65. ncbi A role for dopamine in the processing of drug cues in heroin dependent patients
    Ingmar H A Franken
    Department of Psychology, Erasmus University Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Eur Neuropsychopharmacol 14:503-8. 2004
    ..However, no effect of haloperidol on subjective craving was found. These findings provide preliminary indications that attentional bias in heroin dependent humans is mediated by dopaminergic mechanisms...
  66. ncbi Effect of formoterol with or without budesonide in repeated low-dose allergen challenge
    B Dahlen
    Division of Respiratory Medicine and Allergy, Dept of Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Eur Respir J 33:747-53. 2009
    ..Signs of deteriorating asthma, provoked by low-dose allergen, are prevented by short-term use of budesonide/formoterol but not by temporary use of formoterol alone...
  67. ncbi A MUFA-rich diet improves posprandial glucose, lipid and GLP-1 responses in insulin-resistant subjects
    Juan A Paniagua
    Lipids and Atherosclerosis Research Unit, University Hospital Reina Sofia, Cordoba, Spain
    J Am Coll Nutr 26:434-44. 2007
    ..To study the effects of three weight-maintenance diets with different macronutrient composition on carbohydrate, lipid metabolism, insulin and incretin levels in insulin-resistant subjects...
  68. ncbi Prospective, controlled, cross-over trial of alcohol-based hand gel in critical care units
    Mark E Rupp
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, USA
    Infect Control Hosp Epidemiol 29:8-15. 2008
    ..There are limited data from prospective studies to indicate whether improvement in hand hygiene associated with the use of alcohol-based hand hygiene products results in improved patient outcomes...
  69. ncbi Validation of the premature infant pain profile in the clinical setting
    M Ballantyne
    The Hospital for Sick Children, Toronto, Ontario, Canada
    Clin J Pain 15:297-303. 1999
    ..The purpose of this study was to establish (a) construct validity of the PIPP and (b) inter- and intrarater reliability of the PIPP prospectively in the clinical environment...
  70. ncbi A randomised crossover trial of chemotherapy in the home: patient preferences and cost analysis
    D Rischin
    Division of Hematology and Medical Oncology, Peter MacCallum Cancer Institute, Melbourne, Vic
    Med J Aust 173:125-7. 2000
    ..To determine patient preferences and cost differences between home-based and hospital-based chemotherapy...
  71. ncbi Low-dose cortisol for symptoms of posttraumatic stress disorder
    Amanda Aerni
    Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8029 Zurich, Switzerland
    Am J Psychiatry 161:1488-90. 2004
    ....
  72. ncbi Testosterone treatment in multiple sclerosis: a pilot study
    Nancy L Sicotte
    Division of Brain Mapping, Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Arch Neurol 64:683-8. 2007
    ..To study the effect of testosterone supplementation on men with multiple sclerosis (MS)...
  73. ncbi Optimal insulin pump dosing and postprandial glycemia following a pizza meal using the continuous glucose monitoring system
    Susan M Jones
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Diabetes Technol Ther 7:233-40. 2005
    ..We attempted to identify an optimal insulin pump meal bolus by comparing postprandial sensor glucose values following three methods of insulin pump meal bolusing for a consistent pizza meal...
  74. pmc Acute neuropsychological effects of MDMA and ethanol (co-)administration in healthy volunteers
    G J H Dumont
    Unit for Clinical Psychopharmacology and Neuropsychiatry UCPN, Department of Psychiatry, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Psychopharmacology (Berl) 197:465-74. 2008
    ..Commonly, ecstasy is used in combination with other substances, in particular alcohol (ethanol). MDMA induces both arousing as well as hallucinogenic effects, whereas ethanol is a general central nervous system depressant...
  75. pmc Frequent genital herpes simplex virus 2 shedding in immunocompetent women. Effect of acyclovir treatment
    A Wald
    Department of Medicine, University of Washington, Seattle 98195, USA
    J Clin Invest 99:1092-7. 1997
    ..HSV-2 shedding in the genital mucosa occurs much more frequently than previously appreciated. This frequent reactivation likely plays a role in the epidemic spread of genital herpes worldwide...
  76. ncbi Increasing compression depth during manikin CPR using a simple backboard
    L Ø Andersen
    Department of Anaesthesia, Center of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Acta Anaesthesiol Scand 51:747-50. 2007
    ..The aim of this study was to compare chest compression depth with and without a rigid backboard. The authors hypothesized that the presence of a backboard would result in an increased depth of chest compressions...
  77. ncbi Effects of xanthine oxidase inhibition with allopurinol on endothelial function and peripheral blood flow in hyperuricemic patients with chronic heart failure: results from 2 placebo-controlled studies
    Wolfram Doehner
    Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Circulation 105:2619-24. 2002
    ..We therefore studied the effects of XO inhibition with allopurinol on endothelial function and peripheral blood flow in CHF patients after intra-arterial infusion and after oral administration in 2 independent placebo-controlled studies...
  78. ncbi Risk of injury after alcohol consumption: a case-crossover study in the emergency department
    Guilherme Borges
    Dept de Investigac Servicio de Salud, Div de Investigac Epidemiol Sociales, Instituto Nacional de Psiquiatria and Universidad Autonoma Metropolitana Xochimilco, Calzada Mexico Xochimilco No 101, Col San Lorenzo Huipulco, DF, 14370 Mexico
    Soc Sci Med 58:1191-200. 2004
    ..Patients with the lowest usual involvement with alcohol are subject to a higher elevation in their risk for an injury immediately after alcohol consumption compared to patients who drink more heavily...
  79. ncbi Inhibition of Seminal emission is the main cause of anejaculation induced by a new highly selective alpha1A-blocker in normal volunteers
    Ko Kobayashi
    Sapporo Medical University School of Medicine, Sapporo, Japan
    J Sex Med 5:2185-90. 2008
    ..Recent studies have highlighted the influence of alpha1-adrenoceptor antagonists on ejaculatory function...
  80. ncbi Effect of different mouthrinses on morning breath
    D van Steenberghe
    Department of Periodontology, Oral Pathology and Maxillo-Facial Surgery, Faculty of Medicine, Catholic University of Leuven, Belgium
    J Periodontol 72:1183-91. 2001
    ..CHX-Alc and CHX-CPC-Zn mouthrinses result in a significant reduction of the microbial load of tongue and saliva...
  81. ncbi The effects of low calcium dialysate on arterial compliance and vasoactive substances in patients with hemodialysis
    Soo Jeong Yoo
    Department of Internal Medicine, College of Medicine, Chung Ang University, Seoul, Korea
    Korean J Intern Med 19:27-32. 2004
    ..25 mmol/L) on the changes in arterial compliance (AC), blood pressure (BP), biochemical parameters and vasoactive substances...
  82. ncbi Diesel exhaust inhalation increases thrombus formation in man
    Andrew J Lucking
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK
    Eur Heart J 29:3043-51. 2008
    ..The aim of this study is to investigate the effect of diesel exhaust inhalation on platelet activation and thrombus formation in men...
  83. ncbi The dual-wave bolus feature in continuous subcutaneous insulin infusion pumps controls prolonged post-prandial hyperglycaemia better than standard bolus in Type 1 diabetes
    S W Lee
    Department of Medicine, Loma Linda Medical Center s Diabetes Treatment Center, Loma Linda, CA 92354, USA
    Diabetes Nutr Metab 17:211-6. 2004
    ..Prolonged post-prandial glycaemic excursions are identified using the CGMS. Treating post-prandial hyperglycaemia with dual-wave insulin delivery may help manage chronic hyperglycaemia in patients with diabetes...
  84. ncbi Effect of grapefruit juice volume on the reduction of fexofenadine bioavailability: possible role of organic anion transporting polypeptides
    George K Dresser
    Lawson Health Research Institute, London Health Sciences Centre, UK
    Clin Pharmacol Ther 77:170-7. 2005
    ....
  85. ncbi Dialysate as food: combined amino acid and glucose dialysate improves protein anabolism in renal failure patients on automated peritoneal dialysis
    Hoey Lan Tjiong
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 40, Rotterdam, 3015 GD, The Netherlands
    J Am Soc Nephrol 16:1486-93. 2005
    ..60 +/- 2.38 to 0.35 +/- 3.25 g/d (P = 0.061, NS), improving in six patients. In conclusion, APD with AA plus G dialysate improves protein kinetics. This dialysis procedure may improve the nutritional status in malnourished PD patients...
  86. ncbi A novel function of red wine polyphenols in humans: prevention of absorption of cytotoxic lipid peroxidation products
    Shlomit Gorelik
    Department of Pharmaceutics, David R Bloom Center of Pharmacy, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, Israel
    FASEB J 22:41-6. 2008
    ..These findings explain the potentially harmful effects of oxidized fats found in foods and the important benefit of dietary polyphenols in the meal...
  87. ncbi Effects on postural oscillation and memory functions of a single dose of zolpidem 5 mg, zopiclone 3.75 mg and lormetazepam 1 mg in elderly healthy subjects. A randomized, cross-over, double-blind study versus placebo
    Herve Allain
    Laboratoire de Pharmacologie Experimentale et Clinique, Universite de Rennes 1, Faculte de Medecine, 2 rue du Pr Léon Bernard, CS 34317, 35043 Rennes Cedex, France
    Eur J Clin Pharmacol 59:179-88. 2003
    ..e. usual starting doses in elderly) or placebo were administered at night to 48 healthy elderly volunteers aged 65 years or more. The study included four treatment periods separated by wash-out periods of at least 1 week...
  88. ncbi Methylprednisolone effect on brain volume and enhancing lesions in MS before and during IFNbeta-1b
    A B Rao
    Laboratory of Diagnostic Radiology Research, Clinical Center, NIH, Bethesda, MD 20892, USA
    Neurology 59:688-94. 2002
    ..To determine the effect of IV methylprednisolone (IVMP) on brain fraction volume (BFV), contrast-enhancing (CE) lesions, and white matter lesion load (WMLL) in patients with relapsing-remitting MS treated for acute exacerbations...
  89. ncbi Special low-protein foods ameliorate postprandial off in patients with advanced Parkinson's disease
    Michela Barichella
    Clinical Nutrition Unit, Istituti Clinici di Perfezionamento, Milan, Italy
    Mov Disord 21:1682-7. 2006
    ..8%) was observed. Consumption of LPP in the first part of the day ameliorates off periods in PD patients, but additional studies including pharmacokinetics are needed...
  90. ncbi Bioavailability and urinary excretion of isoflavones in humans: effects of soy-based supplements formulation and equol production
    Sébastien Vergne
    ENITA, Unité Micronutriments, Reproduction, santé, Bordeaux, France
    J Pharm Biomed Anal 43:1488-94. 2007
    ..This difference disappeared when equol excretion was added to daidzein excretion in equol producers. Our results indicated that the production of equol could partly explain the difference in daidzein bioavailability after IF ingestion...
  91. ncbi Effects of thickened feeding on gastroesophageal reflux in infants: a placebo-controlled crossover study using intraluminal impedance
    Tobias G Wenzl
    Kinderklinik, Universitatsklinikum Aachen, Aachen, Germany
    Pediatrics 111:e355-9. 2003
    ..The aim of this randomized, placebo-controlled crossover study was to examine the influence of formula thickened with carob (St. John's bread) bean gum on acid and nonacid GER...
  92. pmc Effective cross-over to granisetron after failure to ondansetron, a randomized double blind study in patients failing ondansetron plus dexamethasone during the first 24 hours following highly emetogenic chemotherapy
    R de Wit
    Rotterdam Cancer Institute and University Hospital Rotterdam, IJsselland Hospital Rotterdam, Albert Schweitzer Hospital Dordrecht, The Netherlands
    Br J Cancer 85:1099-101. 2001
    ....
  93. ncbi Ghrelin stimulates gastric emptying and hunger in normal-weight humans
    F Levin
    Department of Surgery, Danderyd Hospital, SE 182 88 Stockholm, Sweden
    J Clin Endocrinol Metab 91:3296-302. 2006
    ..Ghrelin is produced primarily by enteroendocrine cells in the gastric mucosa and increases gastric emptying in patients with gastroparesis...
  94. ncbi Pain reducing effect of three types of transcutaneous electrical nerve stimulation in patients with chronic pain: a randomized crossover trial
    Albere J A Koke
    Pain Management and Research Center, University Hospital Maastricht, Maastricht, The Netherlands
    Pain 108:36-42. 2004
    ..Because no placebo group was included, no definite conclusions on effectiveness of TENS in general in the treatment of chronic pain could be made...
  95. ncbi Effects of a policosanol supplement on serum lipid concentrations in hypercholesterolaemic and heterozygous familial hypercholesterolaemic subjects
    A Greyling
    School of Physiology, Nutrition and Consumer Sciences, North West University Potchefstroom Campus, South Africa
    Br J Nutr 95:968-75. 2006
    ..An intake of 20 mg/d policosanol for 12 weeks had no significant effect on serum lipid levels in hypercholesterolaemic and heterozygous familial hypercholesterolaemic patients when compared with placebo intake...
  96. ncbi Non-serotonergic pharmacological profiles and associated cognitive effects of serotonin reuptake inhibitors
    J A Schmitt
    Experimental Psychopharmacology Unit, Brain and Behaviour Institute, Universiteit Maastricht, The Netherlands
    J Psychopharmacol 15:173-9. 2001
    ..The impairing and facilitating cognitive effects of paroxetine and sertraline, respectively, may be more pronounced in the elderly depressed patient...
  97. ncbi Lisdexamfetamine dimesylate and mixed amphetamine salts extended-release in children with ADHD: a double-blind, placebo-controlled, crossover analog classroom study
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Biol Psychiatry 62:970-6. 2007
    ..Pharmacologically active d-amphetamine is released from lisdexamfetamine following oral ingestion...
  98. ncbi Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine
    Kelly L Johnston
    Centre for Nutrition and Food Safety, School of Biomedical and Molecular Sciences, University of Surrey, Guildford, United Kingdom
    Am J Clin Nutr 78:728-33. 2003
    ..Accumulating evidence suggests that certain dietary polyphenols have biological effects in the small intestine that alter the pattern of glucose uptake. Their effects, however, on glucose tolerance in humans are unknown...
  99. ncbi Moderate exercise, postprandial lipemia, and skeletal muscle lipoprotein lipase activity
    S L Herd
    Human Muscle Metabolism Research Group, Loughborough University, Loughborough, England
    Metabolism 50:756-62. 2001
    ..79, P <.05). In the fasted state and postprandially, carbohydrate oxidation was lower after exercise (P <.05). Thus moderate exercise attenuates postprandial lipemia, possibly by altering muscle LPL activity...
  100. pmc Sputum eosinophilia and the short term response to inhaled mometasone in chronic obstructive pulmonary disease
    C E Brightling
    Institute for Lung Health, Clinical Sciences Wing, University Hospitals of Leicester, Groby Road, Leicester LE3 9QP, UK
    Thorax 60:193-8. 2005
    ..Whether the response to inhaled corticosteroids is related to the presence of eosinophilic inflammation is unclear...
  101. ncbi Comparison of the effects of calcium loading with calcium citrate or calcium carbonate on bone turnover in postmenopausal women
    Anne M Kenny
    Center on Aging, MC 5215, University of Connecticut Health Center, Farmington, CT 06030 5215, USA
    Osteoporos Int 15:290-4. 2004
    ..05). Calcium citrate decreased markers of bone resorption significantly more than calcium carbonate in postmenopausal women, although no differences in their effects in calcium excretion or PTH were detected...

Research Grants78

  1. Triggers of Abruptio Placentae - A Case Crossover Study of an Ischemic Placental
    Michelle A Williams; Fiscal Year: 2013
    ....
  2. Randomized trial of PEITC as a modifier of NNK metabolism in smokers
    Jian Min Yuan; Fiscal Year: 2012
    ..The major strengths include the need for a randomized, placebo-controlled trial of PEITC, the qualification of the investigators, and the feasibility of the proposed studies. ..
  3. Vascular effects of dietary salt in humans with salt-resistant BP
    William B Farquhar; Fiscal Year: 2013
    ..This comprehensive endothelial assessment in humans during a controlled feeding study will allow us to determine if excess dietary salt is impairing endothelial-dependent vasodilation at both macro- and microvascular levels. ..
  4. Inhibition of Carboxylesterase Metabolism by Ethanol
    Robert B Parker; Fiscal Year: 2011
    ..Understanding this interaction is a necessary component for the safe and effective use of drugs metabolized by carboxylesterases. ! ..
  5. Translational refinement of adaptive communication system for locked-in patients
    Melanie Fried-Oken; Fiscal Year: 2013
    ..The proposed project stresses the translation of basic computer science into clinical care, supporting the proposed NIH Roadmap and public health initiatives. ..
  6. Vascular Endothelial Dysfunction in Older Adults: Dietary Sodium Restriction
    Kristen Jablonski; Fiscal Year: 2010
    ..Finally, this research project and training plan will provide an outstanding platform for research career development. ..
  7. Clinical Translation of Nitrite Therapy to Treat Arterial Aging in Humans
    Douglas R Seals; Fiscal Year: 2012
    ..Overall, the proposed research will provide important new scientific evidence on the effectiveness of sodium nitrite for decreasing the risk of developing cardiovascular diseases with aging. ..
  8. Effects of Yoga on CVD Risk Factors among African Americans: Jackson Heart Study
    Gailen D Marshall; Fiscal Year: 2013
    ..If we find out that it does, then we can provide the nation with an inexpensive way in which to help improve heart health. ..
  9. Climate Variability / Change and the Risks for a Spectrum of Diseases
    Shao Lin; Fiscal Year: 2011
    ....
  10. The Effect of Low Frequency STN DBS on Sleep and Vigilance in PD Patients
    AMY WILLIS AMARA; Fiscal Year: 2013
    ..abstract_text> ..
  11. Mechanisms underlying adverse health consequences of shift work
    Frank A Scheer; Fiscal Year: 2013
    ..We anticipate that this work will lay the groundwork for the development of targeted and timed therapies to counteract the public health burden of shift work. ..
  12. Phase II Therapeutic Trial of Mexiletine
    Richard J Barohn; Fiscal Year: 2010
    ..These secondary measures will be quantified by lndividual Neuromuscular Quality of Life (INQOL), SF-36 (adults), SF-10 (children), grip myotonia, physical exam, and electrophysiological testing, respectively. ..
  13. Obstructive Sleep Apnea in WTC Responders: Role of Nasal Pathology
    Jag Sunderram; Fiscal Year: 2013
    ....
  14. Effects of octanoic acid for treatment of essential voice tremor
    SOREN YVETTE LOWELL; Fiscal Year: 2013
    ..The proposed project will significantly advance evidence-based decisions for the clinical treatment of EVT, providing a vital step toward reducing the debilitating effects f this disorder. ..
  15. Home and community exposures in COPD exacerbation: A pilot case cross-over study
    Susan R Sama; Fiscal Year: 2011
    ....
  16. Smoking, Sex Hormones and Pregnancy
    Sharon S Allen; Fiscal Year: 2013
    ..Further, this study has the potential to inform new and innovative smoking cessation treatments for women of childbearing age. ..
  17. Carbidopa for the treatment of nausea and vomiting in familial dysautonomiaIND #
    Horacio Kaufmann; Fiscal Year: 2010
    ..Their long-term goal is to treat nausea effectively and without side effects, a therapeutic intervention that will markedly improve the quality of life of patients with FD. ..
  18. A multicenter outpatient trial of a bihormonal bionic pancreas
    Steven J Russell; Fiscal Year: 2013
    ....
  19. A Four-arm Prospective, Multicenter Study to Assess the Clinical Efficacy, Effect
    Daniel J Sexton; Fiscal Year: 2013
    ....
  20. Enhancing Dietary Iron and Zinc Bioavailability in Indian Children
    Steven A Abrams; Fiscal Year: 2010
    ..These benefits will lead to larger population-based studies and an enhanced understanding of using nutritional interventions in developing countries to improve health. ..
  21. Preventing Depression in People with Epilepsy: An Extension of Project UPLIFT
    Nancy J Thompson; Fiscal Year: 2010
    ..If one-third of the more than 3 million people in the United states with epilepsy are depressed and we can reduce that number by 12%, 120,000 people will be protected. ..
  22. Dietary fructose and low-grade inflammation
    Mario Kratz; Fiscal Year: 2012
    ..The public health impact of this project might be considerable given that the consumption of fructose in the population is pervasive, and is modifiable on an individual as well as a population level. ..
  23. Collaboration on Alcohol Self-Administration in Adolescents and Young Adults
    SEAN JOSEPH O'CONNOR; Fiscal Year: 2012
    ..The partnership is real and well balanced, and the U01 leadership plan incorporates the collaborative resources of NIAAA. ..
  24. Sensitization of Human Circadian Responses to Light
    Charles A Czeisler; Fiscal Year: 2013
    ..Our findings will provide an important step in understanding how new knowledge about the circadian photoreceptive system can be used to refine and provide better treatment options for circadian rhythm disorders. ..
  25. Asparagus to Zucchini: A Nutrition Education System for Persons with Dementia
    Cameron J Camp; Fiscal Year: 2012
    ....
  26. DOPAMINERGIC SUBSTRATES OF STARTLE GATING ACROSS SPECIES
    Neal R Swerdlow; Fiscal Year: 2013
    ..The findings will inform studies searching for the genes associated with dopamine-linked disorders of impaired sensorimotor gating in humans. ..
  27. Exploring sex differences in the neural correlates of PTSD: Impact of oxytocin
    MARGARET M MORAN-SANTA MARIA; Fiscal Year: 2013
    ..Comparisons between men and women with a history of child abuse with and without PTSD will provide critical information regarding sex differences in the neural substrates of resilience. ..
  28. Evaluating the CG ASSIST Program for Caregiving Dyads
    Patricia C Griffiths; Fiscal Year: 2012
    ....
  29. Genetic Modification of Triggers of Acute Myocardial Infarction
    ANA B BAYLIN; Fiscal Year: 2011
    ..Results from this study may help to identify susceptible sub-populations that can modify their life styles to improve health. ..
  30. Allopregnanolone in Short-Term Smoking Abstinence
    Alicia M Allen; Fiscal Year: 2012
    ..If allopregnanolone is protective against smoking relapse, this information could be incorporated in smoking cessation interventions to improve smoking cessation rates in women. ..
  31. Statistical Methods in HIV Vaccine Efficacy Trials
    Peter B Gilbert; Fiscal Year: 2013
    ..For making progress in these areas, this proposal develops novel statistical methods for the design and analysis of preventative HIV vaccine efficacy trials and of NHP challenge trials. ..
  32. CoEnzyme Q10 in Statin Myopathy
    PAUL DAVIS THOMPSON; Fiscal Year: 2010
    ....
  33. GABA Modulation and Negative Affect in Psychosis
    Stephan F Taylor; Fiscal Year: 2010
    ....
  34. Strategies to Moderate Energy Intake for the Prevention of Obesity in Children
    BARBARA JEAN ROLLS; Fiscal Year: 2013
    ..These data will translate to the development of specific strategies that can be adapted to children's energy needs and inform the design of effective public health messages to help prevent childhood obesity. ..
  35. Rapid response human testing of smokeless tobacco products
    Pamela I Clark; Fiscal Year: 2013
    ....
  36. Transcutaneous electroacupuncture for gastroparesis
    Jiande Chen; Fiscal Year: 2010
    ..A comprehensive team has been assembled to perform the study, including experts in gastrointestinal motility, traditional Chinese medicine and clinical patient care. ..
  37. Characterizing and Predicting Drug Effects on Cognition
    SUSAN E MARINO; Fiscal Year: 2013
    ..Future directions will extend this approach to patients across different disorders (e.g., epilepsy, Alzheimer's) and multiple drug classes (e.g., anticholinergics, antipsychotics). ..
  38. Medication development of a novel therapeutic for smoking cessation
    KENNETH ALAN PERKINS; Fiscal Year: 2013
    ..abstract_text> ..
  39. A model system for abnormalities in electron transport genes in bipolar disorder
    Christine L Konradi; Fiscal Year: 2010
    ..We are trying to replicated and extend these findings, since they open new treatment approaches for BPD, and since they can improve our understanding of the organic mechanisms leading to the clinical symptoms observed in BPD. ..
  40. Phase I Safety Interaction Trial of Ibudilast with Methamphetamine
    Steven Shoptaw; Fiscal Year: 2012
    ..These interaction data are necessary before moving forward with trials of ibudilast in outpatient settings. ..
  41. Time Past Menopause, Duration of Estrogen Deficiency, and Insulin Action
    Rachael E Van Pelt; Fiscal Year: 2013
    ..Confirmation of our hypotheses will provide evidence for a benefit of E2 on insulin action (GDR) when administered early, but not late, after menopause;likely contributing to delayed onset of T2DM. ..
  42. Lipogenesis, lipoprotein flux &CVD risk: role of meal composition &frequency
    Jean Marc Schwarz; Fiscal Year: 2013
    ..These findings could inform efforts to develop evidence-based interventions and dietary guidance to mitigate CVD risk. ..
  43. Behavioral and Neural Consequences of Sleep Loss on Adolescent Affective Function
    Peter L Franzen; Fiscal Year: 2013
    ..Participants will be studied in pairs of friends, enabling us to examine the influence of the peer social context on affective functioning. We will also examine neural and behavioral responses to socially- relevant stimuli. ..
  44. Effectiveness of basic and premium hearing aid features for older adults
    ROBYN MASTERTON COX; Fiscal Year: 2013
    ..This research examines the differences in real world benefits between higher-cost and lower-cost hearing aids, with the goal of providing increased access to successful, lower cost, hearing health care for underserved older adults. ..
  45. Biomechanical Evaluation of Adaptable Ankle-Foot Prostheses
    Andrew H Hansen; Fiscal Year: 2011
    ..Information gathered from able-bodied persons walking on ramp surfaces will also assist in future designs of adaptable ankle-foot prostheses. ..
  46. Phase 2 Study of Mexiletine for the Treatment of Myotonic Dystrophy
    Richard T Moxley; Fiscal Year: 2013
    ..We anticipate that this study has the potential to establish (or discourage) a new indication for the use of mexiletine. ..
  47. Patient safety monitoring in kidney disease with an eDiary.
    Jeffrey C Fink; Fiscal Year: 2013
    ....
  48. The Children's Mercy-Truman-UMKC Center: A New Addition for the Next 5 Years
    William E Truog; Fiscal Year: 2013
    ..Our long-term goal is to harness and leverage our local expertise and population to reduce suffering and death in high-risk infants. ..
  49. Impulsivity and Stimulant Response in Early- and Late-Onset CD with Comorbid ADHD
    Charles W Mathias; Fiscal Year: 2013
    ....
  50. The Memory Benefits of Sleep in Healthy Young, Elderly, and Mild AD Subjects
    Matthew A Tucker; Fiscal Year: 2013
    ..The results of these studies will help to reshape our thinking about the value of sleep as a therapeutic tool to ameliorate age-related memory decline. ..
  51. Ability of Partial Inverse Agonist, Iomazenil, to Block Ethanol Effects in Humans
    DEEPAK CYRIL D'SOUZA; Fiscal Year: 2013
    ..Iomazenil attenuated alcohol intoxication and reduced alcohol-induced driving impairments (n=5). Finally, while ethanol decreases P300 amplitude, iomazenil increases it. ..
  52. Phase II Trial of SGS-742 in Succinic Semialdehyde Dehydrogenase Deficiency
    K Michael Gibson; Fiscal Year: 2013
    ..The project's long term significance centers on identification of effective treatment for SSADH deficiency and related disorders in which neurocognitive dysfunction correlates with GABAergic systems. ..
  53. Prevention of Young Adult Drug Use in Club Settings
    Brenda A Miller; Fiscal Year: 2012
    ..abstract_text> ..
  54. Sleep and Processing Traumatic Memory
    Thomas A Mellman; Fiscal Year: 2013
    ..We will determine which indices of emotional processing are most sensitive to sleep effects. We will also evaluate the influence of characteristics of intervening sleep including measures of REM continuity. ..
  55. Phase 2 Study of Hemin for Treatment and Prevention of Porphyria Attacks
    KARL ELMO ANDERSON; Fiscal Year: 2013
    ..This project will provide the first high quality evidence for efficacy and safety of the drug viewed as the most important available treatment for acute attacks of porphyria. ..
  56. Improving Care Continuity in Drug Abuse Treatment
    Maxine L Stitzer; Fiscal Year: 2010
    ..Overall, the project will provide valuable new data that can be used by policy makers to select treatment transition options that will maximize continuity of care within a drug abuse treatment services delivery system. ..
  57. Pharmacotherapy Impact on Cocaine and Alcohol-derived Reinforcement.
    JENNIFER GRACE PLEBANI; Fiscal Year: 2012
    ..As yet, no efficacious pharmacotherapies for cocaine dependence have been found. The goal of this project is to examine the potential efficacy of cholinergic medications in treating cocaine dependence...
  58. An environmental disinfection intervention to prevent C. difficile transmission
    CURTIS DONSKEY; Fiscal Year: 2013
    ..e., monitoring of cleaning through observation only) versus enhanced cleaning (i.e., including monitoring and feedback using the fluorescent marker method). The primary outcome measure will be incidence of healthcare-associated CDI. . ..
  59. N-of-1 Trials Using mHealth in Chronic Pain
    Richard L Kravitz; Fiscal Year: 2013
    ..Achieving these aims will set the stage for broader uptake of mHealth n-of-1 trials in chronic pain and facilitate use of mHealth n-of-1 trials in designing chronic health care management. ! ..
  60. PAIN MODULATED JAW MOTOR FUNCTION
    Christian Stohler; Fiscal Year: 1999
    ....
  61. Development of Ibudilast as a Novel Treatment for Alcoholism
    Lara Ray; Fiscal Year: 2013
    ..Results from this study will inform a subsequent R01 application to conduct a randomized controlled trial of IBUD for alcoholism. ..
  62. Development of a Model to Examine Corticosteroid Effects on the Hippocampus
    E Sherwood Brown; Fiscal Year: 2009
    ..The study will determine if phenytoin, a medication used for seizures, protects the human brain from the adverse effects of cortisol. ..
  63. MYOCARDIAL ISCHEMIA INDUCED BY INHALED ANESTHETICS
    CHARLES BUFFINGTON; Fiscal Year: 1993
    ..The laboratory studies will provide insight into the underlying mechanisms. The project will improve clinical care of this high-risk population by providing basic science and clinical information...
  64. POLYUNSATURATES AND KC1 TO CONTROL MILD HYPERTENSION
    Frank Sacks; Fiscal Year: 1991
    ..Biochemical validation of compliance with each treatment will be obtained. The discovery of an effective dietary supplement to treat mild hypertension would be of great interest and practical importance...
  65. NASAL IRRITANT SENSITIVITY AND ALLERGIC RHINITIS
    Dennis Shusterman; Fiscal Year: 2000
    ..Physiologic reactivity (above) will be compared with nasal irritant perceptual acuity, as measured with a discrimination task involving pulsed CO2 and filtered air. ..
  66. The Cholinergic Anti-Inflammatory Pathway in Human Obesity and Insulin Resistance
    Karen Teff; Fiscal Year: 2009
    ..Positive findings would support future investigations for the development of a new therapeutic target to lower cytokine levels in obese individuals. ..
  67. DIETARY CHOLESTEROL EFFECTS ON PLASMA LIPOPROTEINS
    PHYLLIS MCPHERSON; Fiscal Year: 1990
    ....
  68. Pharmacoresistance in rats with kainate-induced epilepsy
    F Dudek; Fiscal Year: 2005
    ..abstract_text> ..
  69. Symptoms, Serotonin and Amino Acids in Anorexia Nervosa
    David Jimerson; Fiscal Year: 2007
    ..This exploratory study will assess whether abnormal regulation of the naturally occurring neurochemical serotonin may contribute to this important public health problem. [unreadable] [unreadable]..
  70. Efficacy of The Ketogenic Diet
    John Freeman; Fiscal Year: 2002
    ..The mechanics of the study have gone well with no adverse events and no dropouts. We believe that the recruitment problems have been solved. Since the investigators remain blinded, the results are not available. ..
  71. Kangaroo Care to Blunt Pain in Premature Infants
    Susan Ludington; Fiscal Year: 2004
    ..If the normality assumption is violated, an appropriate transformation will be used before applying the T-test. ..
  72. Effects of Soy on Estrogens in Breast Fluid and Urine
    Gertraud Maskarinec; Fiscal Year: 2010
    ..The NAF approach is the only way to learn more about the beneficial and adverse effects of soy directly in the female breast without applying invasive procedures to women without breast disease or surgery. ..
  73. Molecular Epidemiology of Recurrent Aphthous Stomatitis: Role of Ghrelin
    Lorena Baccaglini; Fiscal Year: 2009
    ..In particular, we are interested in knowing if patients with canker sores have a deficit of ghrelin (a newly discovered hormone involved in growth and mucosal protection from injury). ..
  74. Naltrexone and alprazolam-induced fMRI changes
    CHRIS STREETER; Fiscal Year: 2005
    ..Pretreatment with naltrexone will correlate with a slower decrease in rCBV and less mood-enhancement than when alprazolam is given unopposed. ..
  75. Abuse-Related Effects of Opioids and Adjuvant Drug Used by Chronic Pain Patients
    James P Zacny; Fiscal Year: 2010
    ..g., muscle relaxant B) would be the preferred drug to prescribe when treating chronic nonmalignant pain patients. ..
  76. Effect of Pyridoxamine in Oxalate excretion in Stone Disease and Hyperoxaluria
    Jon Scheinman; Fiscal Year: 2007
    ..The public health implications of this study are in its contributions to preventing common kidney stone disease, and preventing kidney failure in an orphan disease, Primary Hyperoxaluria. [unreadable] [unreadable] [unreadable]..
  77. DRUG-INDUCED SHIVERING--EFFECTS OF A NURSING MEASURE
    BARBARA HOLTZCLAW; Fiscal Year: 1990
    ..If effective, the intervention provides a low cost, easily administered alternative to drugs for shivering suppression and the basis for developing interventions for shivering in other clinical situations...
  78. BIOBEHAVIORAL PREDICTORS OF POSTOP PAIN & IMMUNE STATUS
    Joel Katz; Fiscal Year: 1999
    ..The anticipated morphine-sparing effect may reduce potential adverse effects, decrease treatment costs, and shorten length of hospital stay. ..