control groups

Summary

Summary: Groups that serve as a standard for comparison in experimental studies. They are similar in relevant characteristics to the experimental group but do not receive the experimental intervention.

Top Publications

  1. pmc Usual and unusual care: existing practice control groups in randomized controlled trials of behavioral interventions
    Kenneth E Freedland
    Department of Psychiatry, Washington University School of Medicine, 4320 Forest Park Ave, Suite 301, St Louis, Missouri 63108, USA
    Psychosom Med 73:323-35. 2011
  2. ncbi Change over time in alcohol consumption in control groups in brief intervention studies: systematic review and meta-regression study
    Richard J Jenkins
    Centre for Paediatric Epidemiology and Biostatistics, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, United Kingdom
    Drug Alcohol Depend 100:107-14. 2009
  3. ncbi Headache: the placebo effects in the control groups in randomized clinical trials; an analysis of systematic reviews
    Femke M de Groot
    Department of General Practice, Erasmus Medical Center, Rotterdam, The Netherlands
    J Manipulative Physiol Ther 34:297-305. 2011
  4. ncbi A controlled trial of placebo versus real acupuncture
    Greg Goddard
    Center for Orofacial Pain, Department of Oral and Maxillofacial Surgery, University of California San Francisco, San Francisco, CA, USA
    J Pain 6:237-42. 2005
  5. ncbi Consensus definitions and application guidelines for control groups in cerebrospinal fluid biomarker studies in multiple sclerosis
    Charlotte Teunissen
    Neurological laboratory, Innogentecis and Roche, VU University Medical Center, Netherlands
    Mult Scler 19:1802-9. 2013
  6. ncbi Predictability of quantification of beta-trace protein for diagnosis of cerebrospinal fluid leak: cutoff determination in nasal fluids with two control groups
    Marcelo Hamilton Sampaio
    Department of Otolaryngology Head and Neck, Faculty of Medical Sciences, University of Campinas UNICAMP, Campinas, Sao Paulo, Brazil
    Am J Rhinol Allergy 23:585-90. 2009
  7. ncbi Explanations for improvement in both experimental and control groups
    Heather Becker
    University of Texas, Austin School of Nursing, USA
    West J Nurs Res 25:746-55. 2003
  8. ncbi Carcinogenicity evaluation: comparison of tumor data from dual control groups in the Sprague-Dawley rat
    Paul Baldrick
    Scientific and Regulatory Consulting, Covance Laboratories Ltd, Otley Road, Harrogate, HG3 1PY North Yorkshire, United Kingdom
    Toxicol Pathol 33:283-91. 2005
  9. ncbi Estimating the influenza vaccine effectiveness in elderly on a yearly basis using the Spanish influenza surveillance network--pilot case-control studies using different control groups, 2008-2009 season, Spain
    Camelia Savulescu
    European Centre for Disease Prevention and Control, European Programme for Intervention Epidemiology Training, Stockholm, Sweden
    Vaccine 28:2903-7. 2010
  10. ncbi The effect of waiting: A meta-analysis of wait-list control groups in trials for tinnitus distress
    Hugo Hesser
    Department of Behavioural Sciences and Learning, Linnaeus Centre, Swedish Institute for Disability Research, Linkoping University, Linkoping, Sweden
    J Psychosom Res 70:378-84. 2011

Detail Information

Publications240 found, 100 shown here

  1. pmc Usual and unusual care: existing practice control groups in randomized controlled trials of behavioral interventions
    Kenneth E Freedland
    Department of Psychiatry, Washington University School of Medicine, 4320 Forest Park Ave, Suite 301, St Louis, Missouri 63108, USA
    Psychosom Med 73:323-35. 2011
    To evaluate the use of existing practice control groups in randomized controlled trials of behavioral interventions and the role of extrinsic health care services in the design and conduct of behavioral trials.
  2. ncbi Change over time in alcohol consumption in control groups in brief intervention studies: systematic review and meta-regression study
    Richard J Jenkins
    Centre for Paediatric Epidemiology and Biostatistics, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, United Kingdom
    Drug Alcohol Depend 100:107-14. 2009
    ..This systematic review sought to examine the nature of change in alcohol consumption over time in control groups in brief intervention studies...
  3. ncbi Headache: the placebo effects in the control groups in randomized clinical trials; an analysis of systematic reviews
    Femke M de Groot
    Department of General Practice, Erasmus Medical Center, Rotterdam, The Netherlands
    J Manipulative Physiol Ther 34:297-305. 2011
    ..The purpose of this study is to describe the effects in the placebo and "no treatment" arms in trials with headache patients...
  4. ncbi A controlled trial of placebo versus real acupuncture
    Greg Goddard
    Center for Orofacial Pain, Department of Oral and Maxillofacial Surgery, University of California San Francisco, San Francisco, CA, USA
    J Pain 6:237-42. 2005
    ..463). Subjects were not able to differentiate between real or placebo acupuncture, thereby validating this novel method of administering placebo acupuncture as a good control for acupuncture-naive patients...
  5. ncbi Consensus definitions and application guidelines for control groups in cerebrospinal fluid biomarker studies in multiple sclerosis
    Charlotte Teunissen
    Neurological laboratory, Innogentecis and Roche, VU University Medical Center, Netherlands
    Mult Scler 19:1802-9. 2013
    ..There is a lack of definitions and nomenclature of different control groups and a rationalized application of different control groups...
  6. ncbi Predictability of quantification of beta-trace protein for diagnosis of cerebrospinal fluid leak: cutoff determination in nasal fluids with two control groups
    Marcelo Hamilton Sampaio
    Department of Otolaryngology Head and Neck, Faculty of Medical Sciences, University of Campinas UNICAMP, Campinas, Sao Paulo, Brazil
    Am J Rhinol Allergy 23:585-90. 2009
    ..The majority of Brazilian hospitals have the nephelometric equipment for betaTP detection. This study was designed to determine threshold values for betaTP concentrations in nasal cavity secretions as a predictor of CFS leak...
  7. ncbi Explanations for improvement in both experimental and control groups
    Heather Becker
    University of Texas, Austin School of Nursing, USA
    West J Nurs Res 25:746-55. 2003
    ..assignment to groups protects against false causal inferences that could be made when both the treatment and control groups change because of factors such as testing effects, reactivity, contamination, maturation, history, and other ..
  8. ncbi Carcinogenicity evaluation: comparison of tumor data from dual control groups in the Sprague-Dawley rat
    Paul Baldrick
    Scientific and Regulatory Consulting, Covance Laboratories Ltd, Otley Road, Harrogate, HG3 1PY North Yorkshire, United Kingdom
    Toxicol Pathol 33:283-91. 2005
    ..In this paper, the results of 13 rat carcinogenicity studies, performed between 1991 and 2002, with 2 control groups, are presented...
  9. ncbi Estimating the influenza vaccine effectiveness in elderly on a yearly basis using the Spanish influenza surveillance network--pilot case-control studies using different control groups, 2008-2009 season, Spain
    Camelia Savulescu
    European Centre for Disease Prevention and Control, European Programme for Intervention Epidemiology Training, Stockholm, Sweden
    Vaccine 28:2903-7. 2010
    ..The results suggested a protective effect of the vaccine against laboratory-confirmed influenza in elderly in 2008-2009. The screening method and the test-negative control designs enable estimating IVE using exclusively SISSS data...
  10. ncbi The effect of waiting: A meta-analysis of wait-list control groups in trials for tinnitus distress
    Hugo Hesser
    Department of Behavioural Sciences and Learning, Linnaeus Centre, Swedish Institute for Disability Research, Linkoping University, Linkoping, Sweden
    J Psychosom Res 70:378-84. 2011
    ..The aim of the present study was to quantify the overall effect of wait-list control groups on tinnitus distress.
  11. ncbi Multiple regression analyses in artificial-grammar learning: the importance of control groups
    Anja Lotz
    Department of Psychology, Philipps Universitat Marburg, Marburg, Germany
    Q J Exp Psychol (Hove) 62:576-84. 2009
    ..Here we argue that multiple regression analysis can be successfully combined with the use of control groups to assess whether participants were able to transfer knowledge acquired during training when making judgements ..
  12. ncbi Control groups in psychosocial intervention research: ethical and methodological issues
    L L Street
    National Institute of Mental Health, 6001 Executive Blvd, Room 7160, MSC 9635, Bethesda, MD 20892 9635, USA
    Ethics Behav 12:1-30. 2002
    ....
  13. ncbi Toward rapproachment in the placebo control debate. A calculated compromise of power
    Andrew C Leon
    Weill Medical College of Cornell University, USA
    Eval Health Prof 26:404-14. 2003
    ....
  14. ncbi Testing therapies less effective than the best current standard: ethical beliefs in an international sample of researchers
    David M Kent
    Tufts New England Medical Center, Boston, USA
    Am J Bioeth 3:W11. 2003
    ..To test the range of beliefs regarding the ethics of testing, in resource poor settings, new therapies that are less efficacious but more affordable and feasible than the best current therapeutic standard...
  15. ncbi Comparison groups in autism family research: Down syndrome, fragile X syndrome, and schizophrenia
    Marsha Mailick Seltzer
    Waisman Center, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    J Autism Dev Disord 34:41-8. 2004
    ..We discuss both matching and statistical control procedures and point to next steps in this line of comparative autism family research...
  16. pmc Patterns of stress in schizophrenia
    Julia D Betensky
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Psychiatry Res 160:38-46. 2008
    ....
  17. ncbi Empathic abilities in people with schizophrenia
    Emre Bora
    Melbourne Neuropsychiatry Centre, Psychiatry Department of Melbourne University, Victoria, Australia
    Psychiatry Res 160:23-9. 2008
    ..Studies focusing on dysfunctional brain networks underlying empathy deficits and studies using more experimental measures of empathy should be helpful to unravel the true nature of the empathic failure in patients with schizophrenia...
  18. ncbi What makes placebo-controlled trials unethical?
    Franklin G Miller
    National Institutes of Health
    Am J Bioeth 2:3-9. 2002
    ..Placebo controls are ethically justifiable when they are supported by sound methodological considerations and their use does not expose research participants to excessive risks of harm...
  19. pmc Using event related potentials to explore stages of facial affect recognition deficits in schizophrenia
    Jonathan K Wynn
    VA Greater Los Angeles Healthcare System, MIRECC, Building 210, Los Angeles, CA 90073, USA
    Schizophr Bull 34:679-87. 2008
    ..Our results imply that abnormalities in the later stage of feature decoding could potentially underlie emotion identification deficits in schizophrenia...
  20. ncbi Redefining the randomized controlled trial in the context of acupuncture research
    Rishma Walji
    Leslie Dan Faculty of Pharmacy, University of Toronto, 19 Russell Street, Toronto, Ont, Canada
    Complement Ther Clin Pract 12:91-6. 2006
    ..The randomized controlled trial (RCT) is considered the 'gold standard' methodology for evaluating efficacy of an intervention. It has been argued that RCTs cannot be used to examine the effectiveness of acupuncture...
  21. ncbi The neuropsychology of cannabis and other substance use in schizophrenia: review of the literature and critical evaluation of methodological issues
    Carissa M Coulston
    Academic Discipline of Psychological Medicine, Northern Clinical School, University of Sydney, NSW, Australia
    Aust N Z J Psychiatry 41:869-84. 2007
    ....
  22. ncbi Cognitive improvement after treatment with second-generation antipsychotic medications in first-episode schizophrenia: is it a practice effect?
    Terry E Goldberg
    Zucker Hillside Hospital, 7559 263rd Street, Glen Oaks, NY 11004, USA
    Arch Gen Psychiatry 64:1115-22. 2007
    ..However, none of these studies included healthy controls undergoing repeated testing to assess the possibility that improvements might reflect simple practice effects...
  23. ncbi The importance of preservation of the ethical principle of equipoise in the design of clinical trials: relative impact of the methodological quality domains on the treatment effect in randomized controlled trials
    Benjamin Djulbegovic
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, 12902 Magnolia Dr, Tampa, FL 33612, USA
    Account Res 10:301-15. 2003
    ..We argue that an adequate control intervention can be selected if people designing a trial explicitly take into consideration the ethical principle of equipoise, also known as "the uncertainty principle."..
  24. ncbi 'I wash until it feels right' the phenomenology of stopping criteria in obsessive-compulsive washing
    Karina Wahl
    University of Luebeck, Department of Psychiatry and Psychotherapy, Ratzeburger Allee 160, 23538 Luebeck, Germany
    J Anxiety Disord 22:143-61. 2008
    ..They indicate that the use of subjective criteria and elevated evidence requirements is affected by the perceived significance of the situation in a similar way for obsessional and non-obsessional individuals...
  25. ncbi Homeopathy for depression: a systematic review of the research evidence
    K Pilkington
    Research Council for Complementary Medicine, London, UK
    Homeopathy 94:153-63. 2005
    ..To systematically review the research evidence on the effectiveness of homeopathy for the treatment of depression and depressive disorders...
  26. ncbi Clinical hypertension research tools: the randomized controlled clinical trial
    Daniel T Lackland
    Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Clin Hypertens (Greenwich) 8:427-31; quiz 432-3. 2006
    ..Herein, the authors provide an overview of design features of clinical trials, particularly those useful for designing a hypertension therapeutic clinical trial...
  27. ncbi Study design options in evaluating gene-environment interactions: practical considerations for a planned case-control study of pediatric leukemia
    Michael Goodman
    Department of Epidemiology Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    Pediatr Blood Cancer 48:375-9. 2007
    ..We considered three design options: a full case-control study (Option I), a case-only study (Option II), and a partial case-control study (Option III), in which information on controls is limited to environmental exposure only...
  28. ncbi Design options for case-control studies of gene-environment interactions
    Cheng Cheng
    Department of Biostatistics, St Jude Children s Research Hospital, Memphis, Tennessee
    Pediatr Blood Cancer 48:373-4. 2007
  29. ncbi Inter-correlations between Cloninger's temperament dimensions-- a meta-analysis
    Jouko Miettunen
    Department of Psychiatry, Oulu University and Oulu University Hospital, PO Box 5000, Oulu, Finland
    Psychiatry Res 160:106-14. 2008
    ..In conclusion, we found a medium level negative correlation between NS and HA; other correlations between the dimensions were small. These findings mainly support Cloninger's theory of independent dimensions...
  30. ncbi Striatal dopamine D(2) receptor availability in OCD with and without comorbid social anxiety disorder: preliminary findings
    Franklin R Schneier
    Anxiety Disorders Clinic, New York State Psychiatric Institute, New York, NY 10032, USA
    Depress Anxiety 25:1-7. 2008
    ..Prior findings of decreased D(2) receptor availability in noncomorbid OCD were not confirmed. Decreased D(2) receptor availability was also associated with trait detachment, supporting prior findings in samples of healthy subjects...
  31. ncbi Borderline personality disorder and mood spectrum
    Carmen Berrocal
    Department of Psychiatry, Neurobiology, Pharmacology, and Biotechnologies, University of Pisa, Via Roma 67, Pisa 56126, Italy
    Psychiatry Res 159:300-7. 2008
    ..The results of this study are consistent with previous findings suggesting the importance of mood dysregulations in patients with BPD...
  32. pmc What aspects of emotional functioning are impaired in schizophrenia?
    Ellen S Herbener
    Center for Cognitive Medicine, University of Illinois at Chicago, 912 S Wood Street M C 913, Chicago, IL 60612, USA
    Schizophr Res 98:239-46. 2008
    ....
  33. ncbi Self-reported motivation to smoke in schizophrenia is related to antipsychotic drug treatment
    Alasdair M Barr
    Faculty of Medicine, Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada
    Schizophr Res 100:252-60. 2008
    ..While a number of theories have been proposed to account for such high rates of smoking, little is known about the subjective motivation for why schizophrenia patients smoke in comparison with those without the disease...
  34. ncbi Automatic affective processing impairments in patients with deficit syndrome schizophrenia
    Gregory P Strauss
    Department of Psychology, University of Nevada Las Vegas, Las Vegas, NV 89154, USA
    Schizophr Res 102:76-87. 2008
    ..Results are generally consistent with a mood-congruent processing abnormality and suggest that impaired automatic processing may be core to diminished emotional experience symptoms exhibited in deficit syndrome patients...
  35. ncbi Association study of three polymorphisms in the dopamine D2 receptor gene and schizophrenia in the Russian population
    Mikhail Monakhov
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilova 32, 119991 Moscow, Russia
    Schizophr Res 100:302-7. 2008
    ..02). In conclusion, our findings provide additional evidence for an association between the C957T polymorphism and schizophrenia...
  36. ncbi Norms and standardization of the Brief Assessment of Cognition in Schizophrenia (BACS)
    Richard S E Keefe
    Department of Psychiatry, Box 3207, Duke University Medical Center, Durham, North Carolina 27710, USA
    Schizophr Res 102:108-15. 2008
    ..An education-correction factor was calculated and recommended only for non-schizophrenia patients. Eight different verbal memory tests were found to have equivalent levels of difficulty...
  37. pmc Assessment of social judgments and complex mental states in the early phases of psychosis
    Shannon M Couture
    University of North Carolina at Chapel Hill, Department of Psychology, CB 3270, Davie Hall, Chapel Hill, NC 27599 3270, USA
    Schizophr Res 100:237-41. 2008
    ..Social cognition plays an important role in the functioning of individuals with psychosis. In this study, we explored two areas of social cognition not previously investigated early in the course of psychosis...
  38. ncbi Elucidating semantic disorganisation from a word comprehension task: do patients with schizophrenia and bipolar disorder show differential processing of nouns, verbs and adjectives?
    Susan L Rossell
    Macquarie Centre for Cognitive Science MACCS, Macquarie University, Sydney, NSW 2109, Australia
    Schizophr Res 102:63-8. 2008
    ..most healthy controls perform at ceiling, questioning the validity of observed differences between patient and control groups. A new word definition task examined word comprehension across grammatical categories, i.e...
  39. ncbi Pain perception in schizophrenia: no changes in diffuse noxious inhibitory controls (DNIC) but a lack of pain sensitization
    Stephane Potvin
    Centre de Recherche Fernand Seguin, University of Montreal, Montreal, Canada
    J Psychiatr Res 42:1010-6. 2008
    ..Preliminary experimental studies have shown diminished pain sensitivity in schizophrenia patients. The objective of the study was to investigate the role of excitatory and inhibitory systems on pain perception in schizophrenia...
  40. ncbi Lack of support for the inability to taste phenylthiocarbamide as an endophenotypic marker in patients with schizophrenia and their first-degree relatives
    Michael T Compton
    Emory University School of Medicine, 49 Jesse Hill Jr Drive, S E, Room 333, Atlanta, GA 30303, USA
    Schizophr Res 95:65-9. 2007
    ..Associations between PTC-tasting status and olfactory identification scores also were examined...
  41. pmc The translation of cognitive paradigms for patient research
    Steven J Luck
    Center for Mind and Brain, University of California, Davis, CA 95618, USA
    Schizophr Bull 34:629-44. 2008
    ..Finally, we present examples of 2 experiments, one of which exemplifies our recommendations regarding measurement issues and was a success and one of which was a painful but informative failure...
  42. pmc Building a clinically relevant cognitive task: case study of the AX paradigm
    Angus W MacDonald
    Department of Psychology, University of Minnesota, Minneapolis, MN 55455, USA
    Schizophr Bull 34:619-28. 2008
    ..The development of the expectancy AX paradigm continues, and future developments that may enhance its usefulness are also described...
  43. ncbi Personality in schizophrenia assessed with the Temperament and Character Inventory (TCI)
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo, Japan
    Psychiatry Res 160:175-83. 2008
    ....
  44. ncbi Association of cholesterol and socio-demographic parameters with suicidality in the male patients with schizophrenia
    Darko Marcinko
    University Psychiatric Clinic Rebro, Clinical Hospital Centre Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia
    Psychiatr Danub 20:390-5. 2008
    ....
  45. ncbi Relationships between white matter metabolite abnormalities, cognitive and social functioning in elderly schizophrenic subjects
    Joseph I Friedman
    Schizophr Res 100:356-8. 2008
  46. ncbi Effect of thought disorders on quality of life in patients with schizophrenia
    H Ulas
    Psychiatry Department of Medical School of Dokuz Eylul University, Izmir, Turkey
    Prog Neuropsychopharmacol Biol Psychiatry 32:332-5. 2008
    ..The aim of the present study was to investigate the impact of thought disorder on quality of life in patients with schizophrenia...
  47. ncbi Effects of mindful and non-mindful exercises on people with depression: a systematic review
    Hector W H Tsang
    Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong
    Br J Clin Psychol 47:303-22. 2008
    ..The purpose of this study is to examine the effectiveness of mindful and non-mindful physical exercises as an intervention in managing depression or depressive symptoms based on a systematic literature review...
  48. ncbi Some design issues in trials of microbicides for the prevention of HIV infection
    Thomas R Fleming
    Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA
    J Infect Dis 190:666-74. 2004
    ..The first issue relates to the benefits of using both blinded and unblinded control groups when the placebo regimen may not be inert and when the effectiveness of an intervention heavily depends on ..
  49. pmc Research ethics and evidence based medicine
    R K Lie
    Department of Clinical Bioethics, National Institutes of Health, Bethesda, MD 20852, USA
    J Med Ethics 30:122-5. 2004
    ..It has been thought that this is an issue only in extremely resource poor settings. This paper gives an example from the United Kingdom illustrating that this is also a problem faced by richer countries...
  50. ncbi An observational examination of the literature in diagnostic anatomic pathology
    Elliott Foucar
    Department of Pathology, University of Virginia, Charlottesville, VA, USA
    Semin Diagn Pathol 22:126-38. 2005
    ....
  51. ncbi Trial design and informed consent for a clinic-based study with a treatment as usual control arm
    H B Degenholtz
    Department of Health Services Administration and Center for Bioethics and Health Law, University of Pittsburgh, 3708 5th Ave, Pittsburgh, PA 15213, USA
    Ethics Behav 12:43-62. 2002
    ..Our analysis reveals the tension between ethics and scientific integrity involved with using TAU as a control condition and the difficulty in designing high-quality research in a community-based setting...
  52. ncbi Ethical issues in psychosocial interventions research involving controls
    E R Saks
    University of Southern California Law School, 699 Exposition Blvd, Los Angeles, CA 90089 0071, USA
    Ethics Behav 12:87-101. 2002
    ..explores those issues in the context of a particular kind of research: psychosocial intervention research with control groups. We discuss 4 broad categories of ethical issues: consent, confidentiality, boundary violations, and risk-..
  53. ncbi Using the CABLES model to assess and minimize risk in research: control group hazards
    G P Koocher
    Graduate School for Health Studies, Simmons College, 300 The Fenway, Boston, MA 02115 5898, USA
    Ethics Behav 12:75-86. 2002
    ..Adoption of a thoughtful ethical analysis addressing all 6 CABLES strands in designing research provides a strong protective step toward safeguarding and promoting the well-being of study participants...
  54. ncbi Avoiding a Jekyll-and-Hyde approach to the ethics of clinical research and practice
    Trudo Lemmens
    University of Toronto
    Am J Bioeth 2:14-7. 2002
  55. ncbi Planning of clinical trials
    J P Boissel
    Clinical Pharmacology Department, RTH Laennec School of Medicine, Lyon Cedex, France
    J Intern Med 255:427-38. 2004
    ..As such, it should meet the fundamentals of scientific discovery that guarantee causality between the observed difference and the intervention. All the planning components are thought according to these fundamentals...
  56. ncbi How to deal with multiple treatment or dose groups in randomized clinical trials?
    L A Hothorn
    Institute of Biostatistics, Leibniz University of Hannover, Herrenhaeuser Str 2, D 30419 Hannover, Germany
    Fundam Clin Pharmacol 21:137-54. 2007
    ..Other multiplicity issues (i.e. multiple endpoints, multiple analyses, and subgroup analyses) are discussed...
  57. ncbi Therapeutic beneficence and placebo controls
    Terrence F Ackerman
    University of Tennessee
    Am J Bioeth 2:21-2. 2002
  58. ncbi How to ensure clinical trial sensitivity in psychotropic drug development: a case study
    Sebastian Videla
    Clin Ther 27:252-4. 2005
  59. ncbi Hyperbaric oxygen therapy for radionecrosis: clear advice from confusing data
    Gerard Laden
    J Clin Oncol 23:4465; author reply 4466-8. 2005
  60. ncbi When argument fails
    Charles Weijer
    Dalhousie University
    Am J Bioeth 2:10-1. 2002
  61. ncbi A pilot seminar on ethical issues in clinical trials for cancer researchers in Vietnam
    Richard R Love
    Departments of Medicine and Pediatrics and the Program in Bioethics, University of Wisconsin Medical School, Madison, Wisconsin, USA
    IRB 25:8-10. 2003
  62. ncbi Improving the quality of randomized controlled trials in Chinese herbal medicine, part II: control group design
    Zhao Xiang Bian
    School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China
    Zhong Xi Yi Jie He Xue Bao 4:130-6. 2006
    To discuss the types of control groups in randomized controlled trials (RCTs) of Chinese herbal medicine (CHM), and to provide suggestions for improving the design of control group in future clinical studies in this therapeutic area.
  63. ncbi Fifth revision of Declaration of Helsinki. Clause 29 forbids trials from using placebos when effective treatment exists
    J M Bland
    BMJ 324:975. 2002
  64. ncbi Placebo controls: scientific and ethical issues
    Charles J Kowalski
    University of Michigan
    Am J Bioeth 2:33-4. 2002
  65. ncbi International ethical regulations on placebo-use in clinical trials: a comparative analysis
    Hans Jörg Ehni
    Institut für Ethik und Geschichte der Medizin, Bereich Ethik in der Medizin, Schleichstr, Tubingen
    Bioethics 22:64-74. 2008
    ..Finally, we try to show how the normative difference of each guideline could influence the decision of researchers or IRBs concerning the ethical acceptability of placebo-use...
  66. ncbi Empathy, social functioning and schizotypy
    Julie D Henry
    School of Psychology, University of New South Wales, Sydney, Australia
    Psychiatry Res 160:15-22. 2008
    ..These data show that the relationship between negative schizotypy and social functioning is at least partially attributable to deficits in affective empathy...
  67. ncbi The Periodontitis and Vascular Events (PAVE) pilot study: recruitment, retention, and community care controls
    David J Couper
    Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA
    J Periodontol 79:80-9. 2008
    ....
  68. ncbi Electroacupuncture prophylaxis of postoperative nausea and vomiting following pediatric tonsillectomy with or without adenoidectomy
    Lynn M Rusy
    Department of Pediatric Anesthesiology, Medical College of Wisconsin Children s Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 96:300-5. 2002
    ..The authors studied the effect of electrical P6 acupuncture in awake pediatric patients who had undergone surgery associated with a high incidence of PONV...
  69. ncbi [Budesonide attenuates airway remodeling and modules the expression of Janus protein tyrosine kinase 1, and signal transducers and activators of transcription 6 in asthma: an experiment with mice]
    Xiao hong Chen
    Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, China
    Zhonghua Yi Xue Za Zhi 87:1627-32. 2007
    ..To investigate the effects of budesonide (BUD) on the airway remodeling and the expression of Janus protein tyrosine kinases 1 (JAK1) and signal transducer and activator of transcription 6 (STAT6) in asthma...
  70. ncbi [Relationship between expression of angiopoietin-2 and retinal vascular development in hyperoxic rats]
    Wen ying Liang
    Department of Neonatology, Women and Children Health Care and Medical Center in Luoyang, Luoyang 471000, China
    Zhonghua Er Ke Za Zhi 47:204-8. 2009
    ....
  71. ncbi Assay of fipronil efficacy to prevent canine monocytic ehrlichiosis in endemic areas
    B Davoust
    Direction Régionale du Service de Santé des Armées, BP 16, Armees, 69998 Lyon, France
    Vet Parasitol 112:91-100. 2003
    ..G1 (66 dogs) and G2 (60 dogs) were untreated control groups located in Djibouti, whereas G4 (32 dogs), G5 (13 dogs), G6 (18 dogs) and G7 (4 dogs) were the control groups ..
  72. ncbi Inhibition of experimental angiogenesis of cornea by various doses of doxycycline and combination of triamcinolone acetonide with low-molecular-weight heparin and doxycycline
    Erdinc Aydin
    Department of Ophthalmology, Tulane University Medical School, New Orleans, LA, USA
    Cornea 27:446-53. 2008
    ....
  73. ncbi [Influence of microtubule depolymerization of myocardial cells on mitochondria distribution and energy metabolism in adult rats]
    Yong ming Dang
    Institute of Burn Research, Southwest Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, The Third Military Medical University, Chongqing 400038, China
    Zhonghua Shao Shang Za Zhi 26:18-22. 2010
    ..To investigate the influence of microtubule depolymerization of myocardial cells on distribution and activity of mitochondria, and energy metabolism of cells in adult rats...
  74. ncbi Preliminary studies on the effect of Anaplasma marginale antibodies ingested by Dermacentor andersoni ticks (Acari:Ixodidae) with their blood meal on infections in salivary glands
    K M Kocan
    Department of Veterinary Pathology, College of Veterinary Medicine, Oklahoma State University, Stillwater, 74078, USA
    Exp Appl Acarol 20:297-311. 1996
    ..Trial 1 was done using splenectomized calves (two calves per treated and control groups) while ticks in trial 2 were fed on intact yearling cattle (four cattle per treated and control groups)...
  75. ncbi [The impact of glutamine-enhanced enteral nutrition on clinical outcome of patients with critical illness: a systematic review of randomized controlled trials]
    Hua Jiang
    Department of Traumatic Surgery, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Chengdu 610073, China
    Zhonghua Shao Shang Za Zhi 25:325-30. 2009
    ..To systematically evaluate the influence of glutamine-enhanced enteral nutrition on clinical prognosis and treatment cost of patients with critical illness...
  76. ncbi Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis by dietary curcumin and hesperidin: comparison with the protective effect of beta-carotene
    T Tanaka
    First Department of Pathology, Gifu University School of Medicine, Japan
    Cancer Res 54:4653-9. 1994
    ..At 6 weeks of age, rats were divided into experimental and control groups and fed the diet containing beta-carotene, hesperidin, or curcumin at a dose of 0.5 g/kg diet (500 ppm)...
  77. ncbi The protective effect of HMG-CoA reductase inhibitors against monocrotaline-induced pulmonary hypertension in the rat might not be a class effect: comparison of pravastatin and atorvastatin
    Zo Rakotoniaina
    Laboratory of Experimental Cardiovascular Physiopathology and Pharmacology EA2979, University of Burgundy, BP 87900, 21000, Dijon, France
    Naunyn Schmiedebergs Arch Pharmacol 374:195-206. 2006
    ..45 +/- 4 and 14 +/- 1 for MC + PS, MC + AS, MC, and control groups, respectively)...
  78. ncbi The effects of ageing and sulfur dioxide inhalation exposure on visual-evoked potentials, antioxidant enzyme systems, and lipid-peroxidation levels of the brain and eye
    Derya Kilic
    Department of Physics, Faculty of Arts and Science, Akdeniz University, Kampus, 07058, Antalya, Turkey
    Neurotoxicol Teratol 25:587-98. 2003
    ..The experimental groups were placed in an exposure chamber containing a constant level of 10 ppm SO(2), while control groups were placed in an exposure chamber, which was continually pumped with filtered air, for 1 h/day x 7 days/week ..
  79. ncbi Ornithine decarboxylase and thymidine kinase activities and polyamine levels from selected organs of adult miniature swine receiving three concentrations of dietary menhaden oil
    D W Gaines
    Food and Drug Administration, Center for Food Safety and Applied Nutrition, 8301 Muirkirk Road, Laurel, MD 20708 2476, USA
    Food Chem Toxicol 39:1109-17. 2001
    ....
  80. ncbi Investigation of the microcirculation and the state of oxidative stress in the rat after scorpion envenomation
    Z Sahnoun
    Laboratory of Pharmacologie, Faculty of Medicine, Sfax, Tunisia
    Clin Exp Pharmacol Physiol 34:263-8. 2007
    ..Six groups were used for histomorphometric study: two control groups, two poisoned groups an two melatonin-pretreated and poisoned groups...
  81. ncbi Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis by citrus auraptene in rats
    T Tanaka
    First Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Carcinogenesis 19:425-31. 1998
    ..At 6 weeks of age, animals were divided into experimental and control groups, and fed the diets containing 100 ppm or 500 ppm auraptene...
  82. ncbi [The inhibitive effect of sodium tanshinone II A sulfonic acid on intimal hyperplasia in rabbit iliac artery ballon injury model]
    Yu Cheng Chen
    Cardiovascular Department, West China Hospital of Sichuan University, Chengdu 610041, China
    Zhong Yao Cai 30:811-5. 2007
    ..To study the preventive effect of Sodium Tanshinone II A sulfonic acid on intimal hyperplasia in rabbit iliac artery balloon injury model and explore the possible mechanism...
  83. ncbi Teratogenicity associated with pre-existing and gestational diabetes
    Victoria M Allen
    Halifax, NS, Canada
    J Obstet Gynaecol Can 29:927-44. 2007
    ....
  84. ncbi Recombinant human granulocyte colony-stimulating factor enhanced the resolution of venous thrombi
    Yi kuan Chen
    Department of General Surgery, Second Affiliated Hospital, Chongqing University of Medical Science, Chongqing, Peoples Republic of China
    J Vasc Surg 47:1058-65. 2008
    ....
  85. ncbi Human neural stem cells promote corticospinal axons regeneration and synapse reformation in injured spinal cord of rats
    Peng Liang
    Department of Neurosurgery, First Clinical College, Harbin Medical University, Harbin 150001, China
    Chin Med J (Engl) 119:1331-8. 2006
    ..This paper studied the action of neural stem cell (NSC) in promoting corticospinal axons regeneration and synapse reformation in rats with injured spinal cord...
  86. ncbi Effect of long-term treatment with metformin added to hypocaloric diet on body composition, fat distribution, and androgen and insulin levels in abdominally obese women with and without the polycystic ovary syndrome
    R Pasquali
    Department of Internal Medicine and Gastroenterology, S Orsola Malpighi Hospital, Bologna, Italy
    J Clin Endocrinol Metab 85:2767-74. 2000
    ..Hypocaloric dieting for 1 month similarly reduced BMI values and the waist circumference in both PCOS and control groups, without any significant effect on CT scan parameters...
  87. ncbi Effects of taurine in cellular responses to oxidative stress in young and middle-aged rat liver
    Zuhal Yildirim
    Gazi University, Faculty of Medicine, Department of Medical Biochemistry, 06510 Besevler, Ankara, Turkey
    Ann N Y Acad Sci 1100:553-61. 2007
    ..There was not a significant difference in liver MDA levels between the control groups of young and middle-aged rats (P > 0.05)...
  88. ncbi Celecoxib but not the combination of celecoxib+atorvastatin prevents the development of monocrotaline-induced pulmonary hypertension in the rat
    Zo Rakotoniaina
    Universite de Bourgogne, Dijon, France
    Naunyn Schmiedebergs Arch Pharmacol 378:241-51. 2008
    ..in lung to body weight ratio (L/BW), right ventricular pressure (RVP in mmHg, 31 +/- 3 and 14 +/- 1 for MC and control groups, respectively, P < 0...
  89. ncbi Cerebral blood flow abnormalities induced by transient hypothyroidism after thyroidectomy--analysis by tc-99m-HMPAO and SPM96
    Shigeki Nagamachi
    Department of Radiology, Miyazaki Medical College, Kihara, Japan
    Ann Nucl Med 18:469-77. 2004
    ..In addition, the effects of thyroxine treatment on rCBF changes were studied...
  90. ncbi Implementation of universal influenza immunization recommendations for healthy young children: results of a randomized, controlled trial with registry-based recall
    Allison Kempe
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Pediatrics 115:146-54. 2005
    ..We collaborated with 5 pediatric practices to attempt universal influenza immunization in this age group...
  91. ncbi [Aprotinin (Antilysin Spofa)--its effect on decreasing hemorrhage in the postoperative period in hip arthroplasty]
    K Cvachovec
    Klinika anesteziologie a resuscitace 2 LF UK a IPVZ, Praha
    Acta Chir Orthop Traumatol Cech 68:311-4. 2001
    ....
  92. ncbi Protective effect of sodium selenite and zinc sulfate on intensive swimming-induced testicular gamatogenic and steroidogenic disorders in mature male rats
    Kuladip Jana
    Garrison Institute on Aging, Texas Tech University Health Sciences Center, 3601 4th St, Lubbock, TX 79430, USA
    Appl Physiol Nutr Metab 33:903-14. 2008
    ..05) was seen in rats in the exercised group, compared with rats in both control groups, in paired testicular masses; in epididymal sperm count; in testicular Delta5, 3beta-hydroxysteroid ..
  93. ncbi [Expression of mucin-l and beta-catenin in papillary thyroid carcinoma and the clinical significance thereof]
    Fei He
    Department of Endocrinology, Taizhou Municipal Hospital, Taizhou 318000, China
    Zhonghua Yi Xue Za Zhi 89:393-6. 2009
    ..To investigate the expression levels of mucin-1 (MUC1) and beta-catenin in papillary thyroid carcinoma, the significance thereof in the carcinogenesis and development of tumor...
  94. ncbi [Effects of garlicin on the expression of transcription factor T-bet and GATA-3 in blood lymph cells in rats with allergic rhinitis]
    Dong Chen
    Department of Otorhinolaryngology, First Affiliated Hospital of SUN Yet san University, Guangzhou 510080, China
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 45:133-8. 2010
    ..To investigate the effects of garlicin on the expression of transcription factors T-bet and GATA-3 in blood lymph cells of experimental rats with allergic rhinitis...
  95. ncbi The use of antifibrinolytic agents in spine surgery. A meta-analysis
    J Brian Gill
    Department of Orthopaedic Surgery and Rehabilitation, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9436, Lubbock, TX 79430, USA
    J Bone Joint Surg Am 90:2399-407. 2008
    ..The purpose of the present study was to determine if antifibrinolytic agents reduced blood transfusions in patients managed with spine surgery and to see if one agent had a greater effect than another...
  96. ncbi Anterior cervical discectomy and fusion with implantable titanium cage: initial impressions, patient outcomes and comparison to fusion with allograft
    Douglas B Moreland
    Buffalo Neurosurgery Group, 550 Orchard Park Road, Buffalo, NY 14224, USA
    Spine J 4:184-91; discussion 191. 2004
    ..One of these devices is the titanium Rabea cage (Signus, Alzenau, Germany) [correction]. There are no peer-reviewed objective reports on the use of these cages in cervical discectomy...
  97. ncbi Bone regeneration around implants in the canine mandible with cultured fibroblasts in polyglactin mesh
    Michael S Sparks
    Department of Periodontics, Baylor College of Dentistry The Texas A and M University Health Science Center, Dallas, TX, USA
    J Periodontol 78:1276-87. 2007
    ..HFDDS also is capable of stimulating angiogenesis and wound healing. The purpose of this study was to attempt to evaluate the effects of HFDDS on guided bone regeneration at sites with 1.5-mm peri-implant defects in the canine mandible...
  98. ncbi The vitamin E nutritional status of rats fed on diets high in fish oil, linseed oil or sunflower seed oil
    S R Farwer
    Rheinische Friedrich Wilhelms Universitat Bonn, Germany
    Br J Nutr 72:127-45. 1994
    Twelve groups of eight rats and two control groups of sixteen rats were given semisynthetic diets with 40% energy as fat for a period of 76 d...
  99. ncbi Effectiveness of furosemide in patients on peritoneal dialysis
    Amy Flinn
    Acute Care of the Elderly, London Health Sciences Centre, London, Ontario
    CANNT J 16:40-4. 2006
    ..The aim of this study is to evaluate our use of furosemide and its effect on diuresis in a home peritoneal dialysis program...
  100. ncbi Up-regulated intragraft gene expression, ICAM-1 and IL-2R molecules, and apoptotic epithelial cells during rejection of rat small intestine allografts
    Y Li
    Research Institute of General Surgery, Nanjing Military Area General Hospital of PLA, Nanjing 210002, China
    Chin Med J (Engl) 114:1089-94. 2001
    ....
  101. ncbi Burn injury alters beta-adrenergic receptor and second messenger function in rat ventricular muscle
    C Wang
    Department of Anesthesiology, Harvard Medical School, Boston, MA, USA
    Crit Care Med 24:118-24. 1996
    ..In the present study, myocardial tissues were used as a model of beta-adrenergic receptors to study burn injury-induced alterations in receptors and in signal transduction...

Research Grants75

  1. Surgical amelioration of type 2 diabetes: Hormones, microbiota and mitochondria
    PETER J contact HAVEL; Fiscal Year: 2010
    ..All tissue analyses will be performed at 1 and 3 months after surgery in IT, Sham and non-surgical control groups. PUBLIC HEALTH RELEVANCE: The clinical observation that bariatric surgery reverses T2DM provides researchers ..
  2. Effects of Standardized Aerobic Exercise-Training on Neurocognitive and Neurodege
    Thomas O Obisesan; Fiscal Year: 2010
    ..exercise-training by the intervention group, all baseline tests will be repeated in both the intervention and control groups. Between groups cognitive performance will be compared using appropriate multivariate methods...
  3. RADIATION-INDUCED THYROID CANCER
    Heinz Ulrich G Weier; Fiscal Year: 2011
    ..b>Control groups will be comprised of children who developed thyroid cancer without prior radiation exposure as well as tumors ..
  4. Genetic Epidemiology of Life-Threatening Influenza Infection in Children
    Adrienne Randolph; Fiscal Year: 2009
    ..and innate immune response of children with life-threatening LRTI from influenza infection alone to 7 control groups including children with healthy lungs, severe LRTI from respiratory syncytial virus, and LRTI from influenza ..
  5. Abdominal Symptom Phenotypes: Pathways to New Biomarkers
    Robert Shulman; Fiscal Year: 2010
    ..and girls in Aim 1 and identify potential biomarkers, namely proteins whose levels differ between IBS and Control groups. 3) Advances in high throughput genomics and proteomics have increased the potential for new biomarkers ..
  6. Hypoplastic Left Heart Syndrome: Expression of RHD in the Fetus?
    Pirooz Eghtesady; Fiscal Year: 2013
    ..myosin serum titers in mothers of HLHS babies (as found in patients with rheumatic fever), compared with three control groups. To extend these studies, we will compare groups of pregnant women referred for fetal echocardiography (echo) ..
  7. Community Ambulation Following Hip Fracture
    Jay Magaziner; Fiscal Year: 2013
    ..The study is designed to detect at least a 20 percentage point difference between the exercise and control groups in the primary outcome with 90 percent power (alpha=. 05) in an intention to treat analysis...
  8. Role of T Cell Mediated Immunity In Emotion And Stress Responsiveness
    Leonardo H Tonelli; Fiscal Year: 2012
    ..b>Control groups will consist of naive RAG2-/- mice under different immunization protocols and reconstituted RAG2-/- mice not ..
  9. Restorative Yoga for Therapy of the Metabolic Syndrome (RHYTHMS) study
    Alka M Kanaya; Fiscal Year: 2012
    ..Participants in the yoga and control groups will participate in group classes twice per week for the first 6 weeks, once per week during weeks 7-12, and ..
  10. GENETIC SUSCEPTIBILITY TO LIPID-LOWERING DRUG-INDUCED MYOPATHIES
    GEORGIRENE VLADUTIU; Fiscal Year: 2012
    ..Preliminary studies have identified a highly associated notch-like gene (p<0.001 vs. combined control groups) localized in muscle and CNS tissue and predicted to have a role in regulatory properties of muscle ..
  11. RNA-Seq studies of Gene Expression in Cells and Networks in FI and ACC in Autism
    Barbara J Wold; Fiscal Year: 2010
    ..We propose to use laser micro-dissection to investigate gene expression in specific neuronal and non-neuronal populations in the cortical areas of interest in the autism-A, autism-B and control groups.
  12. OMEGA-3 SUPPLMENTATION DECREASES INFLAMMATION AND FETAL OBESITY IN PREGNANCY
    Sylvie Hauguel De Mouzon; Fiscal Year: 2010
    ..insutin sensitivity witt be examined by characterizing the expression of PPARy in WAT of both supptemented and control groups. Additionatty, w witl investigate the direct affect of n-3 pf4 on the expression of adiponectin and PPARy ..
  13. Reversing Non-adherence in American Indians with Diabetes Mellitus Type Two
    Marlene K Wilken; Fiscal Year: 2012
    ..Goal 3: Monitor, compare, and report outcomes of the experimental and control groups at recommended intervals for the duration of the study...
  14. Effects of Hypoxia on Craniofacial Morphology and Molecular Signaling
    FRANCIS JOEL SMITH; Fiscal Year: 2011
    ..normoxic control groups, and among hypoxic groups compared to the normoxic group...
  15. Effects of maternal cortisol on fetal and neonatal growth and metabolism
    Maureen Keller-Wood; Fiscal Year: 2013
    ..will be slightly accelerated in these fetuses, resulting in slightly earlier delivery as compared to the control groups, and we will test the hypotheses that there will be an impaired insulin response to increases in glucose ..
  16. Acceptance-based Group Intervention for Binge Eating
    Niloofar Afari; Fiscal Year: 2012
    ..eating will be randomized to receive either four 2-hour weekly ACT intervention groups or brief MOVE-II active control groups after their participation in MOVE!...
  17. Brain Structure and Function in Adolescents after the Fontan Operation
    MICHAEL JOHN RIVKIN; Fiscal Year: 2012
    ..In Aim 1, Fontan and control groups will be compared on Magnetic Resonance Imaging (MRI) measures of brain structure...
  18. Adipose-Derived Stromal/Stem Cell Therapy for Pressure Ulcers
    Xiying Wu; Fiscal Year: 2012
    ..S. and abroad. With its background in adipose stromal/stem cell biotechnology, LaCell and its consultants are uniquely positioned to address this unmet medical need. ..
  19. Intranasal deferoxamine to treat stroke in young and older, male and female rats
    SAMUEL SCOTT PANTER; Fiscal Year: 2013
    ..The time course for improvement in behavioral- functional scores between the DFO-treated and the control groups during the 28-day survival will be evaluated...
  20. Health Care Partners in Cancer Prevention and Care Among Aged - Competing Renewal
    Eva Kahana; Fiscal Year: 2013
    ..the "Speak Up" facilitated discussion groups (N=480) will be compared to participants in "Connect" attention control groups (N=480). The latter program addresses important goals of enhancing civic and social engagement...
  21. Peer groups for healthy pregnancy &HIV prevention for young Malawian women
    Kathleen F Norr; Fiscal Year: 2013
    ..After attrition, a final sample of 345 in the intervention and in the control groups will provide adequate power to detect medium effects...
  22. ROLE OF TNF IN BLADDER INFLAMMATION
    David J Klumpp; Fiscal Year: 2010
    ..will test this hypothesis by first establishing the prevalence of elevated RANTES in urines of IC patients and control groups by taking advantage of our unique access to a cohort of 600 urine samples from a nationwide IC epidemiology ..
  23. Circle of Willis variability and migraine
    BRETT LEE CUCCHIARA; Fiscal Year: 2010
    ..outcome measure will be a comparison of the frequency of an incomplete circle of Willis between migraine and control groups. Additional evaluation of individual circle of Willis anomalies, the composite of circle of Willis and ..
  24. Physical Telerahabilitation in Veterans with Multiple Sclerosis
    MITCHELL TAYLOR WALLIN; Fiscal Year: 2012
    ..A sample of eligible veterans with MS will be recruited within VISN 5 and randomized to the intervention and control groups. Randomization into these groups will also be stratified by two Expanded Disability Status Scale groups (EDSS ..
  25. Dissemination of a Theory-Based Bone Health Program in Online Communities
    Eun Shim Nahm; Fiscal Year: 2012
    ..will be assessed using a randomized controlled trial employing a 3-group design (2 intervention and 1 control groups) with repeated measures (baseline, 8 weeks, 6, 12, and 18 months)...
  26. Immunity in alcoholic hepatitis.
    Zhang Xu Liu; Fiscal Year: 2013
    ..Plasma levels of proinflammatory and anti-inflammatory cytokines/mediators in control groups and AH patients will be measured by multiplex assays;the phenotypes and functions of PBMC subsets (NK/NKT, ..
  27. Essential Features of Neural Damage in Mild Traumatic Brain Injury
    Scott R Sponheim; Fiscal Year: 2012
    ..To date we have studied over 150 individuals divided into bTBI, bTBI+PTSD, PTSD, and control groups and found evidence of diffuse white matter abnormalities associated with bTBI...
  28. Immunologic mechanisms in post-Lyme disease syndrome
    Armin Alaedini; Fiscal Year: 2011
    ..of the current application is the established availability of specimens from PLDS patients and important control groups, which is made possible by collaborations with internationally-recognized investigators in the areas of Lyme ..
  29. The Moderating Influence of Personality on Cognitive Stimulation Outcomes in Pers
    Nikki L Hill; Fiscal Year: 2013
    ..Eligible subjects are randomized to treatment and control groups. The intervention consists of a variety of individually tailored cognitively stimulating recreational ..
  30. Functional Brain Imaging and Appetite-Related Hormones Pre and Post Obesity Surge
    Allan Geliebter; Fiscal Year: 2013
    ..Two surgical groups, laparoscopic RYGB and gastric banding (GB), will be compared to two control groups: i) participants losing weight on a 3-mo formula diet (WL), and ii) those who qualify for, but choose not to ..
  31. Survivorship Plans and Outcomes in Underserved Breast Cancer Survivors
    Rose C Maly; Fiscal Year: 2013
    ..Our specific aims are to assess and compare between experimental and control groups the following primary outcomes at one year post-intervention: 1) discussion and implementation of recommended ..
  32. Sidenafil Impacts Exercise Performance in Adolescent Survivors of the Fontan
    Robert E Shaddy; Fiscal Year: 2013
    ..The rate of decline (trajectory) in VAT measured within the sildenafil and control groups will be compared over the 3 year study period as the primary endpoint...
  33. The Role of GPR120 and Omega-3 Fatty Acids in Steatosis and Systemic Inflammation
    Sarah Carlson; Fiscal Year: 2013
    ..KO and WT control groups (KO control and WT control, respectively) will receive standard rodent chow...
  34. Lunch in the Bag: Packing More Fruit, Vegetables, Grain in Preschool Sack Lunches
    DEANNA MARIE HOELSCHER; Fiscal Year: 2013
    ..centers (n=40) that require parents to send sack lunches from home will be randomized to intervention and control groups. Families (n=800) will be enrolled as parent-child dyads comprised of the primary lunch packer and one 3 to 5 ..
  35. A Pap Test Intervention to Enhance Decision Making among Pacific Islander Women
    Sora P Tanjasiri; Fiscal Year: 2013
    ..organizational samples and recruit and follow the cohorts of PI females and males in the intervention and control groups 5...
  36. Maintaining Exercise and Healthy Eating in Older Adults
    Phillip G Clark; Fiscal Year: 2010
    ..Participants will be randomized into intervention and control groups stratified by previous SENIOR Project group assignment...
  37. Antibody Biomarkers for Early Detection of Tuberculosis
    D Mitchell Magee; Fiscal Year: 2012
    ..To accomplish this, we will obtain sera from well-defined patient and control groups, and screen these sera on a unique and novel platform, nucleic acid programmable protein arrays (NAPPA), which ..
  38. Psychoeducation for BMT caregivers: Biobehavioral markers and outcome
    Mark L Laudenslager; Fiscal Year: 2012
    ..many intervention studies have used convenience samples, failed to randomize treatments, did not include control groups for comparison purposes, or omitted biomarkers...
  39. Structural Analysis of NAT Acetylation, Substrate Specificity and Polymorphisms
    Kylie J Walters; Fiscal Year: 2010
    ..Bladder cancer patients exhibit elevated levels of arylamine-adducts compared to control groups, some of which have been demonstrated to be poor substrates for NATs...
  40. Enhancing Civilian Support for Military Tobacco Control
    Ruth E Malone; Fiscal Year: 2013
    ..Conduct focus groups with members of (a) veterans'groups, (b) public health groups, and (c) tobacco control groups to explore and describe perceptions about military tobacco control;3) Conduct a content analysis of messages ..
  41. Effects of the Built Environment, Crime &Food Prices on BMI, Activity &Eating
    Natalie Colabianchi; Fiscal Year: 2012
    ..The key advantage of the MTO data is participants were randomized to treatment and control groups, which would likely eliminate any baseline differences among these groups...
  42. Enhancing Civilian Support for Military Tobacco Control
    Ruth E Malone; Fiscal Year: 2012
    ..Conduct focus groups with members of (a) veterans'groups, (b) public health groups, and (c) tobacco control groups to explore and describe perceptions about military tobacco control;3) Conduct a content analysis of messages ..
  43. Development for RCT of Gluten Free Diet in Gliadin-Positive Schizophrenia
    Deanna L Kelly; Fiscal Year: 2013
    ..Treatment and control groups will receive a gluten-free diet with addition of non-gluten starch in the treatment group and identical-..
  44. Community-based End-of-life Intervention for African American Dementia Caregivers
    GLORIA J BONNER; Fiscal Year: 2013
    ..design, controlled efficacy trial, HCPs with no EOL care plans will be assigned to either EduAct or attention control groups. We will deliver 9 waves of 4 weekly sessions, a 4-mo booster tailored to residual knowledge deficits...
  45. International Center of TCM for Cancer
    Lorenzo Cohen; Fiscal Year: 2010
    ..much of the research lacks appropriate methodologies of clinical investigation including randomization, control groups, and blinding, as well as lack of documentation on compliance and outcomes...
  46. Control Systems Engineering for Optimizing a Prenatal Weight Gain Intervention
    Danielle Symons Downs; Fiscal Year: 2013
    ..PA with e-health technology mechanisms, randomization/retention/data collection procedures with treatment and control groups, and to establish user acceptability...
  47. HCMV Vaccine produced from BAC-MVA that Blocks Epithelial and Fibroblast Entry
    Don J Diamond; Fiscal Year: 2013
    ..RM and properties of NAb generated against the pentamer complex in sera and saliva from vaccinated and control groups will be assessed in preventing natural HCMV isolate infection of ARPE-19 cells...
  48. POSTMORTEM NEUROCHEMICAL STUDIES IN SUICIDE
    Victoria Arango; Fiscal Year: 2013
    ..We hypothesize that MDD suicides will over-express TPH2 compared to the nonsuicide MDD and control groups. Alternatively, TPH2 expression in suicides may have anatomically restricted changes compared to MDD non-..
  49. College Students as Facilitators to Reduce Adolescent Obesity Disparity
    Deborah L Slawson; Fiscal Year: 2013
    ..trial design will be used and 6 rural high schools will be randomly assigned to the intervention and control groups. Approximately 1440 adolescents will be included as study subjects...
  50. Therapeutic Strategies for Spinal Cord Injury
    Radhika Vaishnav; Fiscal Year: 2009
    ..Tissue sparing, functional and locomotor recovery will also be compared among the treatment and control groups. Aim 2 will test the hypothesis that a combination of antioxidant therapy with calpain inhibition will produce ..
  51. An alternate therapy for treatment of IBD and prevention of colon cancer
    Moul Dey; Fiscal Year: 2012
    ..animals to oral treatments will be determined by comparing macroscopic and microscopic scorings with untreated control groups. Dose dependency, efficacy comparison with known drugs and bioavailability of BSP in blood and urine, will be ..
  52. Th2 effects on eicosanoid pathways: implications for altered innate responses in
    Sally E Wenzel; Fiscal Year: 2010
    ..in asthma exacerbations, both at the level of tissue obtained from individuals dying of asthma (as compared to control groups), as well as in living asthmatics during an exacerbation of asthma...
  53. Enhancing Psychological Capital to Foster Health Outcomes in Homeless Young Women
    DONNA LYNN REW; Fiscal Year: 2013
    ..Quantitative data will be collected at baseline, immediately following the four sessions of intervention or control groups, and 4 weeks later...
  54. Endothelial Progenitor Cells in Diabetes and Renal Failure
    Karen A Lapidos; Fiscal Year: 2010
    ..of pbECs, the anti-thrombogenic, anticoagulant, and inflammatory activities of pbECs derived from patient and control groups will be quantified and compared on a novel biomaterial...
  55. Gene-Environment Interaction Effects on HIV Risk
    Brian Mustanski; Fiscal Year: 2012
    ..In addition to this "treatment condition", two natural control groups exist: (1) youth living in other public housing neighborhoods that are equivalent on census measures of ..
  56. Tai Chi for Treating Major Depressive Disorder in Underserved Chinese Americans
    Albert S Yeung; Fiscal Year: 2012
    ..We hypothesize that at the conclusion of 12-weeks, Tai Chi participants, as compared to control groups, will demonstrate a) greater improvement in depressive symptoms (Hamilton Depression Severity Index-17, Beck ..
  57. Promoting Self-Management in Stroke Survivors Using Health IT
    Kamakshi Lakshminarayan; Fiscal Year: 2013
    ..b>control groups at 3 months after enrollment...
  58. Environmental Strategies &Behavior Change to Reduce Overeating in Obese Children
    Thomas N Robinson; Fiscal Year: 2013
    ..The primary outcome analysis will compare individual trajectories of change in BMI in the treatment and control groups over the full 18-month follow-up, using random regression models...
  59. VULNERABILITY TO ANXIOLYTIC ABUSE IN WOMEN
    Suzette M Evans; Fiscal Year: 2010
    ..or impulsivity and assess their response to alcohol and the stimulant d-amphetamine (AMPH) relative to matched control groups. We will also conduct a parallel study in men...
  60. The role of GLT1 in the modulation of alcohol-drinking behavior in P rats.
    Youssef Sari; Fiscal Year: 2013
    ..We will also investigate the effects of GLT1 activation in EtOH-drinking behavior in Wistar rats as comparison control groups. Our working hypothesis in aim 1 is that an increase in GLT1 function, via up- regulation or activation, ..
  61. Improving decision making for patients with prolonged mechanical ventilation
    CHRISTOPHER ETHAN COX; Fiscal Year: 2013
    ..We will use generalized linear models to test for differences in outcomes between decision aid and usual care control groups over a 6-month follow up period...
  62. Consequences of voluntary intake of ethanol &nicotine during peri-adolescence
    Eric A Engleman; Fiscal Year: 2013
    ..b>Control groups drinking ethanol, nicotine, or water alone will also be used to assess the impact of concurrent intake as ..
  63. MULTIDIMENSIONAL HORMONAL ASSESSMENT OF PTSD
    Sheila Wang; Fiscal Year: 1999
    ..e., the National Center for PTSD Division at the West Haven, CT VA Medical Center. Reference is made to control groups of at least 30 normal subjects of each sex, although the source of the control subjects and other details ..
  64. CHOLESTEROL TREATMENT MODEL FOR LOW INCOME PATIENTS
    Ross Simpson; Fiscal Year: 1993
    ..The randomized trial will include 40 providers and 400 patients equally divided into intervention and control groups. All providers will use a standardized screening protocol, but control group providers will receive no ..
  65. Acupuncture to Prevent Postoperative Paralytic lleus
    JOSEPH CHIANG; Fiscal Year: 2004
    ..Additional objectives are to: 1) compare post-surgical quality of life status between treatment and control groups in terms of pain, use of opioid analgesics, nausea, vomiting, insomnia, abdominal distention/fullness, ..
  66. VA Low Vision Intervention Trial (LOVIT) II
    Joan Stelmack; Fiscal Year: 2009
    ..analysis will compare the mean changes in VA LV VFQ-48 visual reading ability scores between treatment and control groups using a t-test for independent groups...
  67. EXERCISE--NURSING INTERVENTION FOR FUNCTIONAL RECOVERY
    Beverly Roberts; Fiscal Year: 2000
    ..of age and older admitted to general medical units will be randomly assigned to the experimental (n = 80) and control groups (n = 80)...
  68. DEVELOPMENT OF CLINICAL MARKER FOR PERILYMPH FISTULA
    Steven Telian; Fiscal Year: 1993
    ..more common than previously appreciated, but are characterized by a lack of prospective design and appropriate control groups. Phase I of this study proposes to utilize the unique constituency of perilymph proteins to develop a ..
  69. Evaluating Patient Information Prescriptions
    NANCY RODERER; Fiscal Year: 2006
    ..unreadable] [unreadable] In each RCT, patients in both intervention and control groups will receive standard clinical care in their clinic visits...
  70. Environmental Risk Factors and Canine Malignant Lymphoma
    Elizabeth Bertone Johnson; Fiscal Year: 2005
    ..The proposed case-control study will use hospital records to identify cases of CML and 2 control groups of dogs, one consisting of dogs with benign tumors and one consisting of dog with non-cancer chronic diseases, ..
  71. Exploring the effect of a low-fat diet and/or exercise on change in inflammatory
    Deborah Young; Fiscal Year: 2009
    ..that regular physical activity may reduce CRP levels, but previous studies have had small sample sizes and no control groups. In contrast, only a few cross-sectional studies have assessed associations among a low-fat diet and CRP, and ..
  72. ECONOMIC ANALYSIS OF THE FAST TRACK INTERVENTION
    EDWARD FOSTER; Fiscal Year: 2007
    ..These children were randomly assigned to intervention or control groups and are being followed over time...
  73. REPRODUCTIVE TOXICOLOGY AND EPIDEMIOLOGY
    Bill Lasley; Fiscal Year: 2003
    ..The epidemiologic study design provides information linking cause and effect by including appropriate control groups and simultaneous exposure assessment...
  74. Study design importance in analyzing emerging pathogens
    Anthony Harris; Fiscal Year: 2005
    ..case-control studies performed to analyze risk factors for antibiotic resistant pathogens have used different control groups and thus yielded different results...
  75. ANOREXIA NERVOSA: PREVALENCE, DETERMINANTS, TREATMENT
    PAUL GARFINKEL; Fiscal Year: 1980
    ..These included ballet students (N equals 183), fashion students (N equals 56), and control groups of university students (N equals 81) and music students (N equals 35) as well as patients with anorexia ..