epidemiologic research design
Summary: The form and structure of analytic studies in epidemiologic and clinical research.
Publications220 found, 100 shown here
- Safety and efficacy of simplified antibiotic regimens for outpatient treatment of serious infection in neonates and young infants 0-59 days of age in Bangladesh: design of a randomized controlled trialAbdullah H Baqui
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Pediatr Infect Dis J 32:S12-8. 2013..Because access to care is limited in settings with high mortality, exclusive reliance on the current recommendation of 7-10 days of parenteral antibiotic treatment is a barrier to provision of adequate treatment of newborn infections...
- Simplified antibiotic regimens for the management of clinically diagnosed severe infections in newborns and young infants in first-level facilities in Karachi, Pakistan: study design for an outpatient randomized controlled equivalence trialAnita K M Zaidi
Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan
Pediatr Infect Dis J 32:S19-25. 2013..Alternative, simpler antibiotic regimens that could be used in outpatient settings have the potential to save thousands of lives...
- Calculating measures of biological interactionTomas Andersson
Stockholm Centre for Public Health, Sweden
Eur J Epidemiol 20:575-9. 2005..Finally, we show how this output can be used as input in an Excel sheet that is set up to calculate the measures of biological interaction to be used for the assessment...
- Building multivariable regression models with continuous covariates in clinical epidemiology--with an emphasis on fractional polynomialsP Royston
Cancer Division, MRC Clinical Trials Unit, London, UK
Methods Inf Med 44:561-71. 2005....
- Quantitative assessment of unobserved confounding is mandatory in nonrandomized intervention studiesR H H Groenwold
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
J Clin Epidemiol 62:22-8. 2009..Our objective was to review methods to control for observed confounding, as well as unobserved confounding..
- Instrumental variables I: instrumental variables exploit natural variation in nonexperimental data to estimate causal relationshipsJeremy A Rassen
Brigham and Women s Hospital, Boston, MA 02120, USA
J Clin Epidemiol 62:1226-32. 2009..It gives examples of instruments used in clinical epidemiology and concludes with an outline on estimation of effects...
- On the nondifferential misclassification of a binary confounderElizabeth L Ogburn
Department of Biostatistics, Harvard University, Boston MA, USA
Epidemiology 23:433-9. 2012..We also present an analytic proof of the result for the effect of treatment among the treated and describe extensions to measures conditional on or standardized over other covariates...
- Case-crossover design in air pollution epidemiologyJ J K Jaakkola
Institute of Occupational Health, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Eur Respir J Suppl 40:81s-85s. 2003..Case-crossover design is amenable for studying the effects of varying short-term air pollution exposure on health outcomes with an abrupt onset, such as myocardial infarction or asthma attack...
- Comparing respondent-driven sampling and targeted sampling methods of recruiting injection drug users in San FranciscoAlex H Kral
Urban Health Program, RTI International, 114 Sansome Street, Suite 500, San Francisco, CA 94104, USA
J Urban Health 87:839-50. 2010....
- Poor quality of reporting confounding bias in observational intervention studies: a systematic reviewRolf H H Groenwold
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
Ann Epidemiol 18:746-51. 2008..To systematically review observational studies on medical interventions to determine the quality of reporting of confounding...
- Overcoming the winner's curse: estimating penetrance parameters from case-control dataSebastian Zollner
Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA
Am J Hum Genet 80:605-15. 2007..Finally, we show that application of the method to case-control data can improve the design of replication studies considerably...
- Reporting participation in epidemiologic studies: a survey of practiceLindsay M Morton
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
Am J Epidemiol 163:197-203. 2006..The authors conclude that epidemiologists need to address declining participation and to report participation consistently, including for biologic specimen collection...
- The use of primary care databases: case-control and case-only designsLiam Smeeth
Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, UK
Fam Pract 23:597-604. 2006..The principles underlying these case-only designs are presented along with examples of their use. The advantages and limitations of the different designs are discussed...
- The Generation R Study: design and cohort update 2010Vincent W V Jaddoe
The Generation R Study Group AE006, Erasmus Medical Center, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
Eur J Epidemiol 25:823-41. 2010..Eventually, results forthcoming from the Generation R Study have to contribute to the development of strategies for optimizing health and healthcare for pregnant women and children...
- Analysis of individual drug use as a time-varying determinant of exposure in prospective population-based cohort studiesB H Ch Stricker
Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
Eur J Epidemiol 25:245-51. 2010..However, such estimates may be biased in the presence of time-dependent confounders which are themselves affected by prior exposure...
- Using risk-based sampling to enrich cohorts for endpoints, genes, and exposuresClarice R Weinberg
Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Am J Epidemiol 166:447-55. 2007....
- Choosing a retrospective design to assess joint genetic and environmental contributions to riskC R Weinberg
Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Am J Epidemiol 152:197-203. 2000..The investigator must also consider certain practical issues, such as the availability of parents or sibling controls...
- Design and analysis of group-randomized trials: a review of recent methodological developmentsDavid M Murray
Department of Psychology, College of Arts and Sciences, University of Memphis, Memphis, TN, USA
Am J Public Health 94:423-32. 2004..We encourage investigators who conduct GRTs to become familiar with these developments and to collaborate with methodologists who can strengthen the design and analysis of their trials...
- 'Why me?' versus 'why now?'--differences between operational hypotheses in case-control versus case-crossover studiesMalcolm Maclure
School of Health Information Science, University of Victoria, Victoria, British Columbia, Canada
Pharmacoepidemiol Drug Saf 16:850-3. 2007
- Problematic variation in local institutional review of a multicenter genetic epidemiology studyRita McWilliams
Bloomberg School of Public Health, Johns Hopkins Medical Institutions, Baltimore, MD, USA
JAMA 290:360-6. 2003..Sequencing of the human genome provides an immense resource for studies correlating DNA variation and epidemiology. However, appropriately powered genetic epidemiology studies often require recruitment from multiple sites...
- Seven deadly sins of environmental epidemiology and the virtues of precautionPhilippe Grandjean
Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark
Epidemiology 19:158-62. 2008....
- Can incentives undermine intrinsic motivation to participate in epidemiologic surveys?Marika Wenemark
Department of Medicine and Health Sciences, Division of Community Medicine, Linkoping University, 581 83, Linkoping, Sweden
Eur J Epidemiol 25:231-5. 2010..Incentives may undermine motivation in studies in which the intrinsic motivation of the respondents is already high...
- The INTERPHONE study: design, epidemiological methods, and description of the study populationElisabeth Cardis
International Agency for Research on Cancer, 150 cours Albert Thomas, 69372, Lyon, Cedex 08, France
Eur J Epidemiol 22:647-64. 2007..Particular attention was paid to estimating the amount and direction of potential recall and participation biases and their impact on the study results...
- Study of return rate and return time of undeliverable postal lettersAndrea Schmidt-Pokrzywniak
Institute of Clinical Epidemiology, Medical Faculty, University of Halle Wittenberg, Magdeburgerstr 8, 06097, Halle, Germany
Eur J Epidemiol 25:467-70. 2010..Three hundred and three letters (98.2%) were returned as undeliverable. The return rates only slightly differed by layout of the envelopes, region and deliverer...
- Early life patterns of common infection: a latent class analysisSarah J Hepworth
Centre for Epidemiology and Biostatistics, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Room 8 49, Paediatric Epidemiology Group, Worsley Building, Clarendon Way, Leeds LS2 9JT, UK
Eur J Epidemiol 25:875-83. 2010..Other children in the home had the greatest association with infectious class membership. Latent class analysis provided a flexible method of investigating the relationship between multiple symptoms and demographic and lifestyle factors...
- Selective reporting biases in cancer prognostic factor studiesPanayiotis A Kyzas
Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece
J Natl Cancer Inst 97:1043-55. 2005..We probed these biases in a meta-analysis of a prognostic factor for head and neck squamous cell cancer (HNSCC) mortality that has drawn wide attention--the status of the tumor suppressor protein TP53...
- Experience with multiple control groups in a large population-based case-control study on genetic and environmental risk factorsE R Pomp
Department of Clinical Epidemiology, C7 P, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
Eur J Epidemiol 25:459-66. 2010..Our experience with the intricacies of dealing with two control groups may be useful to others when thinking about an optimal research design or the best statistical approach...
- The Shanghai Women's Health Study: rationale, study design, and baseline characteristicsWei Zheng
Center for Health Services Research, Department of Medicine, Vanderbilt University, Nashville, TN 37232 8300, USA
Am J Epidemiol 162:1123-31. 2005..The resources from the cohort will be valuable in future studies of environmental exposures and biomarkers for the risk of cancer and other chronic diseases...
- Causal effects in clinical and epidemiological studies via potential outcomes: concepts and analytical approachesR J Little
University of Michigan, Ann Arbor 48109 2029, USA
Annu Rev Public Health 21:121-45. 2000....
- The case for a global human genome epidemiology initiativeMuin J Khoury
Nat Genet 36:1027-8. 2004
- The effect of concurvity in generalized additive models linking mortality to ambient particulate matterTimothy O Ramsay
Health Canada, Ottawa, Canada
Epidemiology 14:18-23. 2003....
- The role of GIS: coping with space (and time) in air pollution exposure assessmentDavid Briggs
Small Area Health Statistics Unit, Department of Epidemiology and Public Health, Faculty of MedicineImperial College London, London, United Kingdom
J Toxicol Environ Health A 68:1243-61. 2005....
- Community based participatory research: a promising approach for increasing epidemiology's relevance in the 21st centuryMargaret W Leung
Division of Health and Social Behavior, University of California, Berkeley, School of Public Health, 140 Warren Hall, Berkeley, CA 94720 7360, USA
Int J Epidemiol 33:499-506. 2004....
- The Rotterdam Study: objectives and design updateAlbert Hofman
Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
Eur J Epidemiol 22:819-29. 2007..epib.nl/rotterdamstudy). This article gives the reasons for the study and its design. It also presents a summary of the major findings and an update of the objectives and methods...
- An overview of the Canadian Study of Health and AgingI McDowell
Department of Epidemiology and Community Medicine, University of Ottawa, Ontario, Canada
Int Psychogeriatr 13:7-18. 2001..The present article describes the origins and objectives of the study, provides an overview of its design, organization, and data collection methods, and offers a brief summary of the main results...
- Estimating interaction between genetic and environmental risk factors: efficiency of sampling designs within a cohortAlexandre Bureau
Centre de Recherche Universite Laval Robert Giffard, Universite Laval, Quebec, Canada
Epidemiology 19:83-93. 2008..It was possible to estimate the interaction effect with precision close to that of the full cohort when using case-cohort or nested case-control samples containing fewer than half the subjects of the cohort...
- Reducing overestimation in reported mobile phone use associated with epidemiological studiesKari Tokola
Tampere School of Public Health, University of Tampere, Tampere, Finland
Bioelectromagnetics 29:559-63. 2008..The estimates obtained in our study may not be applicable in other contexts, but similar methods could be used to reduce bias in other studies...
- Respondent-driven sampling to recruit MDMA users: a methodological assessmentJichuan Wang
Center for Interventions, Treatment and Addictions Research, Wright State University School of Medicine, 3640 Colonel Glenn Highway, Dayton, OH 45435, USA
Drug Alcohol Depend 78:147-57. 2005..RDS has the potential to be widely employed in studies of illicit drug-using populations...
- Issues in the reporting of epidemiological studies: a survey of recent practiceStuart J Pocock
Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT
BMJ 329:883. 2004..To review current practice in the analysis and reporting of epidemiological research and to identify limitations...
- Sample size determination for hierarchical longitudinal designs with differential attrition ratesAnindya Roy
Center for Health Statistics, University of Illinois at Chicago, 1601 W Taylor St, Chicago, Illinois 60612, USA
Biometrics 63:699-707. 2007..e., power characteristics) for a test of treatment-by-time interaction(s) for designs based on either subject-level or cluster-level randomization. The general methodology is illustrated using two characteristic examples...
- Valid consent for genomic epidemiology in developing countriesDave A Chokshi
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
PLoS Med 4:e95. 2007
- Identifying optimal risk windows for self-controlled case series studies of vaccine safetyStanley Xu
Institute for Health Research, Kaiser Permanente Colorado, Denver, CO, U S A
Stat Med 30:742-52. 2011..Both simulation studies and vaccine safety data applications show that our proposed approach is effective in identifying medium and long-risk windows...
- The Shanghai Changfeng Study: a community-based prospective cohort study of chronic diseases among middle-aged and elderly: objectives and designXin Gao
Department of Endocrinology and Metabolism, Zhong Shan Hospital, Fudan University, 200032 Shanghai, China
Eur J Epidemiol 25:885-93. 2010..15,000 subjects of 40 years or over are planned to be recruited. The rationale, objectives and design of this study are described in this paper...
- Population ageing research: a family of disciplinesRonald P Stolk
Healthy Ageing Population and Society HAPS, University of Groningen, Groningen, The Netherlands
Eur J Epidemiol 24:715-8. 2009....
- The Paris prospective birth cohort study: which design and who participates?B Clarisse
Laboratoire Santé Publique et Environnement, EA 4064, Faculte des Sciences Pharmaceutiques et Biologiques, Universite Rene Descartes, 4 avenue de l Observatoire, 75270 Paris Cedex 06, France
Eur J Epidemiol 22:203-10. 2007....
- Users' guide to the surgical literature. Case-control studies in surgical journalsAlexandra Mihailovic
Department of Surgery, Toronto General Hospital Research Institute, Toronto, Ont
Can J Surg 48:148-51. 2005..Most of these studies appear instead to be retrospective cohort studies or comparisons of case series...
- Distribution of study designs in four major US journals of obstetrics and gynecologyE F Funai
Divisions of Maternal Fetal Medicine and Gynecologic Oncology and Department of Obstetrics and Gynecology, New York University School of Medicine, New York, N Y, USA
Gynecol Obstet Invest 51:8-11. 2001..To classify and compare articles, based on the study design, in four leading US obstetrics and gynecology journals...
- From networks to populations: the development and application of respondent-driven sampling among IDUs and Latino gay menJesus Ramirez-Valles
Community Health Sciences, University of Illinois Chicago, School of Public Health, Chicago, IL 60612 4394, USA
AIDS Behav 9:387-402. 2005..Recruitment differences were observed across cities, but the samples were comparable. RDS showed broader population coverage than TLS, especially among individuals at high risk for HIV...
- The future of BiobankTom Meade
Lancet 362:492. 2003
- Determining causation of work-related upper extremity disordersRobert M Szabo
Department of Orthopaedic Surgery, University of California, Davis, School of Medicine, 4860 Y Street, Sacramento, CA 95817, USA
Clin Occup Environ Med 5:225-34, v. 2006..Terms such as "repetitive stress," "repetitive strain," and "cumulative trauma" should be abandoned, and we should educate our patients as to the multiple risk factors for upper extremity pain...
- Reported residential pesticide use and breast cancer risk on Long Island, New YorkSusan L Teitelbaum
Department of Community Medicine, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
Am J Epidemiol 165:643-51. 2007..This study is the first known to suggest that self-reported use of residential pesticides may increase breast cancer risk. Further investigation in other populations is necessary to confirm these findings...
- Mobile telephones and cancer--a review of epidemiological evidenceMichael Kundi
Institute of Environmental Health, Department for Occupational and Social Hygiene, Medical Faculty, University of Vienna Kinderspitalgasse 15 A 1095 Vienna Austria
J Toxicol Environ Health B Crit Rev 7:351-84. 2004..3 and 4.6 with highest overall risk for acoustic neuroma (3.5) and uveal melanoma (4.2), and there is evidence for enhanced cancer risk with increasing latency and duration of mobile phone use...
- On a supplemented case-control designRuth M Pfeiffer
Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 8030, Bethesda, Maryland 20892 7244, USA
Biometrics 61:584-90. 2005....
- Challenges in operationalizing the DSM-IV clinical significance criterionJanette Beals
American Indian and Alaska Native Programs, University of Colorado Health Sciences Center, Aurora 80045 0508, USA
Arch Gen Psychiatry 61:1197-207. 2004..The American Indian Service Utilization, Psychiatric Epidemiology, Risk and Protective Factors Project (AI-SUPERPFP) offered a unique opportunity to examine the success of this effort...
- [Epidemiologic challenges in rare diseases]S Rückinger
Ludwig Maximilians Universitat Munchen
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 51:483-90. 2008..Challenges in risk factor research and related to therapeutic or preventive trials are presented. Examples from epidemiologic practice are given...
- Inhaled corticosteroids and hip fracture: disease or drugs?Tjeerd P van Staa
Am J Respir Crit Care Med 168:128; author reply 129. 2003
- Prevalence of lower-limb ulceration: a systematic review of prevalence studiesIan D Graham
School of Nursing, Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada
Adv Skin Wound Care 16:305-16. 2003..To determine the prevalence of leg ulcers reported in the literature...
- Classifying periodontitis among adolescents: implications for epidemiological researchRodrigo Lopez
Department of Community Oral Health and Pediatric Dentistry, Faculty of Health Sciences, University of Aarhus, Aarhus, Denmark
Community Dent Oral Epidemiol 31:136-43. 2003..We assess the extent to which the use of different case definition systems may influence the outcome of descriptive and analytical epidemiological studies...
- Back pain prevalence in nursing personnel: measurement issuesNancy N Menzel
College of Nursing, University of Florida, Gainesville, FL, USA
AAOHN J 52:54-65. 2004....
- Data collected in the Canadian Study of Health and AgingI McDowell
Department of Epidemiology and Community Medicine, University of Ottawa, Ontario, Canada
Int Psychogeriatr 13:29-39. 2001..This report describes the data collection and processing procedures, summarizes the content of each data set, and outlines the information collected in sufficient detail to permit its suitability for secondary analyses to be scrutinized...
- A recommended method for obtaining the age at onset of dementia from the CSHA databaseF Rouah
Centre for Clinical Epidemiology and Community Studies, Jewish General Hospital, Montreal, Quebec, Canada
Int Psychogeriatr 13:57-70. 2001..899 while the intraclass correlation coefficient, ICC(2,1), was .898. This method could prove useful for researchers using the CSHA data who need an AAO for those subjects with dementia...
- Overcoming ecologic bias using the two-phase study designJon Wakefield
Department of Statistics, University of Washington, Seattle, WA 98195 7232, USA
Am J Epidemiol 167:908-16. 2008..This example shows that the two-phase design removes ecologic bias and produces gains in efficiency over the use of case-control data alone. The authors discuss the advantages and disadvantages of the approach...
- The Union Carbide disaster in Bhopal: a review of health effectsV Ramana Dhara
Arch Environ Health 57:391-404. 2002....
- The study of group-level factors in epidemiology: rethinking variables, study designs, and analytical approachesAna V Diez Roux
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48101 2548, USA
Epidemiol Rev 26:104-11. 2004
- Descriptive studies: what they can and cannot doDavid A Grimes
Family Health International, PO Box 13950, Research Triangle Park, NC 27709, USA
Lancet 359:145-9. 2002..Hypotheses about causation from descriptive studies are often tested in rigorous analytical studies...
- [Sample selection in epidemiologic studies]Andrzej Zielinski
Przegl Epidemiol 56:489-98. 2002..Some important sources of selection bias and methods of avoiding it are also addressed in this article...
- Cigarette smoking and risk of breast cancer in womenIrma H Russo
Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Lancet 360:1033-4. 2002
- Are comparisons the answer to understanding behavioral aspects of aging in racial and ethnic groups?Keith E Whitfield
Department of Psychology and Neuroscience, 9 Flowers Drive, P O Box 90085, Duke University, Durham, NC 27708, USA
J Gerontol B Psychol Sci Soc Sci 63:P301-8. 2008..Our goal is to encourage the use of multiple methodological designs in the study of issues related to racial and ethnic minorities by demonstrating some of the advantages of lesser employed approaches...
- Methodological aspects of epidemiological studies of periodontal diseasesAlbert Kingman
Periodontol 2000 29:11-30. 2002
- Potentials and pitfalls in analytical headache epidemiological studies--lessons to be learned from the Head-HUNT studyK Hagen
Department of Clinical Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
Cephalalgia 27:403-13. 2007..Despite the limitations of the head-HUNT study, we believe that the results so far have provided clues to causes and preventive factors of headache that should be explored in other populations and in prospective studies...
- Risk of ischemic cerebrovascular disease in alpha1-antitrypsin deficiencyAlessandro Pezzini
Circulation 108:e62-3; author reply e62-3. 2003
- Calculating measures of biological interaction using RHenrik Kallberg
IMM, Institute for Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Eur J Epidemiol 21:571-3. 2006
- Design considerations in the sequential analysis of matched case-control dataM Fazil Baksh
Department of Epidemiology and Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK
Stat Med 24:853-67. 2005..Design issues such as sample size evaluation and error rates are identified and addressed. The methodology is illustrated and evaluated using both real and simulated data sets...
- When to use relative risk or odds ratios in describing study resultsDan M Mayer
Ann Emerg Med 46:385-6; author reply 386. 2005
- Generalized approaches to partitioning the attributable risk of interacting risk factors can remedy existing pitfallsChristina Rabe
Department of Medical Informatics, Biometry and Epidemiology, University of Erlangen Nuremberg, Waldstrasse 6, 91054 Erlangen, Germany
J Clin Epidemiol 60:461-8. 2007..To clarify the properties of different approaches to estimate the contribution of single-risk factors to the disease load in a population...
- Epidemiological studies based on small sample sizes--a statistician's point of viewAnnette Kjaer Ersbøll
Department of Animal Science and Animal Health, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
Acta Vet Scand Suppl 98:127-40. 2003..Examples from veterinary epidemiological research and recommendations for each step are given together with relevant references to the literature...
- Interaction: A word with two meanings creates confusionAnders Ahlbom
Eur J Epidemiol 20:563-4. 2005
- Current guidelines on good reporting of analytical observational studies in epidemiologyL A Boden
The University of Edinburgh, Ashworth Laboratories, West Mains Road, Edinburgh, UK
Equine Vet J 40:84-6. 2008
- Issues in reporting epidemiological studies: study raises several concernsKarl Heinz Jöckel
BMJ 330:146; author reply 146-7. 2005
- Data suppression strategies used during surveillance data release by sexually transmitted disease prevention programsPhilip Christopher Delcher
Office of Epidemiology, Division of Disease Prevention, Virginia Department of Health, 109 Governor s St, Suite 321, Richmond, VA 23219, USA
J Public Health Manag Pract 14:E1-8. 2008..This study investigates the data suppression or statistical disclosure limitation (DL) practices used during surveillance data Release by sexually transmitted disease (STD) prevention programs...
- Cumulative risk and population attributable fraction in preventionCaroline H Davis
Department of Psychology, Arizona State University, Tempe 85283, USA
J Clin Child Adolesc Psychol 32:228-35. 2003..National data sets from Great Britain (the British Births Cohort Study [BCS]) and the United States (National Longitudinal Study of Youth [NLSY]) are used to explore this pattern of effects...
- Selection of important variables and determination of functional form for continuous predictors in multivariable model buildingWilli Sauerbrei
Institute of Medical Biometry and Medical Informatics, University Medical Center Freiburg, Stefan Meier Strasse 26, 79104 Freiburg, Germany
Stat Med 26:5512-28. 2007..While acknowledging that further research is needed, we argue why MFP is our preferred approach for multivariable model building with continuous covariates...
- Within- and between-cohort variation in measured macronutrient intakes, taking account of measurement errors, in the European Prospective Investigation into Cancer and Nutrition studyPietro Ferrari
Unit of Nutrition and Cancer, International Agency for Research on Cancer, Lyon, France
Am J Epidemiol 160:814-22. 2004..After calibration, the two components had a similar weight. This observation has important implications for the analysis of multicenter studies because the between-cohort component provides a large part of the overall heterogeneity...
- Epidemiology of breastfeeding: advances and multidisciplinary applicationsRafael Perez-Escamilla
Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
Adv Exp Med Biol 554:45-59. 2004..This chapter also illustrates how Cox regression and logistic regression can be applied to BF research...
- Genetic association studies in stroke: methodological issues and proposed standard criteriaMartin Dichgans
Department of Neurology, Klinikum Grosshadern, Munich, Germany
Stroke 36:2027-31. 2005..A large number of candidate gene association studies have attempted to identify genes implicated in stroke, but there have been few replicable and robust associations reported...
- Imputation of missing dates of death or institutionalization for time-to-event analyses in the Canadian Study of Health and AgingM F Dubois
Gerontology and Geriatrics Research Center, Sherbrooke University Geriatric Institute, Quebec, Canada
Int Psychogeriatr 13:91-7. 2001..This constitutes a valuable addition to the CSHA data since it precludes the loss of information that results from discarding subjects with missing occurrence dates in time-to-event analyses...
- The Canadian Study of Health and Aging: organizational lessons from a national, multicenter, epidemiologic studyK Rockwood
Division of Geriatric Medicine, Dalhousie University, Canada
Int Psychogeriatr 13:233-7. 2001..In hindsight, several important features of the study would be repeated. Future studies might profitably consider a longer funding period for analysis, and a more strategic approach to in-depth, supplementary studies...
- Study organization in the Canadian Study of Health and AgingI McDowell
Department of Epidemiology and Community Medicine, University of Ottawa, Ontario, Canada
Int Psychogeriatr 13:41-8. 2001..The discussion proposes some guiding principles for administering multicenter studies...
- Effect of formal statistical significance on the credibility of observational associationsJohn P A Ioannidis
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
Am J Epidemiol 168:374-83; discussion 384-90. 2008..Bayes factors may be used routinely to interpret "significant" associations...
- The structural equation modeling technique did not show a response shift, contrary to the results of the then test and the individualized approachesSara Ahmed
Clinical and Health Informatics Research Group, McGill University, Montreal, Quebec, Canada
J Clin Epidemiol 58:1125-33. 2005..The purpose of the present article was to contrast three methodologic approaches for evaluating response shift to develop a proposed set of HRQL measurement recommendations under circumstances where response shift is expected to occur...
- [Epidemiological research on migrant health in Germany. An overview]H Zeeb
Weltgesundheitsorganisation, Genf, Schweiz
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 49:845-52. 2006..This paper presents an overview of methods and findings of epidemiological studies related to migrants in Germany. It also describes needs and challenges for future research...
- Needlestick injuries in the United States. Epidemiologic, economic, and quality of life issuesJennifer M Lee
Abt Associates, Inc, Bethesda, Maryland, USA
AAOHN J 53:117-33. 2005..However, widespread use of safety devices might be more easily justified on economic grounds when the full clinical and economic benefits of these new technologies are considered, especially within the context of injury prevention...
- Epidemiology of sepsis: an updateD C Angus
Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh, PA, USA
Crit Care Med 29:S109-16. 2001..To place new information, such as the role of genetic predisposition, in the correct context, it is essential that such studies be conducted...
- Nurse staffing level and nosocomial infections: empirical evaluation of the case-crossover and case-time-control designsStephane Hugonnet
Infection Control Program, Department of Internal Medicine, University of Geneva Hospitals, Geneva, Switzerland
Am J Epidemiol 165:1321-7. 2007..The case-crossover methodology in hospital epidemiology is a promising alternative to traditional approaches, but selection of the referent periods is challenging...
- Asthma and other allergic diseases in 13-14-year-old schoolchildren in Urmia, Iran. [corrected]M H Rahimi Rad
Department of Internal Medicine, Urmia University of Medical Sciences, Urmia, West Azerbaijan, Islamic Republic of Iran
East Mediterr Health J 13:1005-16. 2007..1%. With the video questionnaire, the prevalence of wheeze was lower; 7.4% for wheeze at rest ever and 4.6% during the past 12 months. Boys had a significantly higher prevalence for most items examined except for eczema...
- A systematic review on the application of pharmacoepidemiology in assessing prescription drug-related adverse events in pediatricsXuemei Luo
Center for Patient Safety and Clinical Quality, Duke University Health System, Durham, NC, USA
Curr Med Res Opin 23:1015-24. 2007....
- Systematic review of methods and results of studies of the genetic epidemiology of ischemic strokeEnrico Flossmann
Stroke Prevention Research Unit, Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
Stroke 35:212-27. 2004....
- Thrombophilias and adverse pregnancy outcome - A confounded problem!Willem J Kist
Department of Obstetrics and Gynaecology, VU University Medical Centre, Amsterdam, The Netherlands
Thromb Haemost 99:77-85. 2008..The differences we have identified reflect the differential impact of these confounders. These data emphasise the importance of more uniform research...
- The American Cancer Society Cancer Prevention Study II Nutrition Cohort: rationale, study design, and baseline characteristicsEugenia E Calle
American Cancer Society, Atlanta, Georgia 30329, USA
Cancer 94:500-11. 2002....
- Strep-EURO: progress in analysis and research into severe streptococcal disease in Europe, 2003-2004Aftab Jasir
Euro Surveill 10:E050203.3. 2005
- Determining and visualising at-risk groups in case-control dataR J Marshall
Department of Community Health, University of Auckland, New Zealand
J Epidemiol Biostat 6:343-8. 2001..They demarcate subgroups that, in the three examples, are easy to interpret and would not have been found by other methods. Scaled rectangle diagrams are a useful way to visualise the results...
- EATING DISORDERS--GENETIC EPIDEMIOLOGYCynthia Bulik; Fiscal Year: 2000..At the end of the three year period, Dr. Bulik will have received sufficient high-quality training and experience to be a highly productive independent research scientist in genetic epidemiology. ..
- Predictors of Smoking Among Adolescents and Young AdultsLorena Siqueira; Fiscal Year: 2004..Her long term goals are to evaluate how know researchcan be applied to clinical settings, design more effective intervention strategies and conduct outcome research. ..
- Risk Factors for Psychopathology in the WHO WMH SurveysRonald Kessler; Fiscal Year: 2009..Third, the level of detail in the description of data analysis plans has been substantially expanded in this revised submission in response to reviewer comments. ..
- Hurricane Katrina Community Advisory GroupRonald C Kessler; Fiscal Year: 2010....
- Outreach and Treatment for Depression in the Labor ForceRonald Kessler; Fiscal Year: 2005..This is an extremely important opportunity for rapid and widespread dissemination in an area of research where dissemination of positive results has traditionally been a serious problem. ..
- MENTAL DISORDERS AS RISK FACTORS FOR SUBSTANCE DISORDERSRonald Kessler; Fiscal Year: 2003....
- Quantifying the Value of Value-Based PurchasingRonald Kessler; Fiscal Year: 2006..abstract_text> ..
- Maternal obesity, intrauterine gene expression and breast cancerKARIN MICHELS; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Structural Models to Bridge Observational and Randomized Evidence: HAART and AIDSStephen Cole; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- Structural models and direct and indirect effects of alcohol use on HIV infectionStephen R Cole; Fiscal Year: 2010..Second, it will provide innovations and detailed worked examples in quantitative methods for complex observational data analysis. ..
- Ethnic Group Differences in Mental Health DisparitiesJames Jackson; Fiscal Year: 2007..unreadable] [unreadable]..
- Family Connections Across Generations and NationsJames Jackson; Fiscal Year: 2006..The proposed study will help us anticipate, understand, and design support programs to cope with the challenges and problems facing individuals at all generation positions, families, and societies in the new century. ..
- Validation of Preschool and High School Diet RecallKARIN MICHELS; Fiscal Year: 2006..Lastly we will determine whether the validity of recall depends on characteristics such as time between diet record and FFQ, number of children, gender of the subject, and nutritional status. ..
- METHODOLOGIC ISSUES IN NUTRITIONAL EPIDEMIOLOGYKARIN MICHELS; Fiscal Year: 2002..We aim to provide guidance to researchers who wish to explore diet-disease relations in how to use data best to obtain most valid results and avoid pitfalls which might produce misleading associations. ..
- Lifetime body weight and premenopausal breast cancerKARIN MICHELS; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- AFRICAN AMERICAN AGING RESEARCH TRAINING NETWORKJames Jackson; Fiscal Year: 2002..The PI anticipates that if 25 students have this experience, a significant proportion may ultimately gain a funded NIA grant. ..
- Effects of major changes in alcohol availabilityRobin Room; Fiscal Year: 2008..unreadable] [unreadable]..
- Phenotypes for Drug Abuse:Epidemiologic-Genetic ApproachDeborah Hasin; Fiscal Year: 2008..abstract_text> ..
- EPIDEMIOLOGIC STUDIES OF ALCOHOL USE DISORDERSDeborah Hasin; Fiscal Year: 2002..If received, the ISA will enable Dr. Hasin to focus on her research, on developing new skills and knowledge, and contributing to an understanding of alcohol use disorders. ..
- Mechanistic models in occupational cancer epidemiologyDavid Richardson; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- NEIGHBORHOOD ENVIRONMENTS AND CARDIOVASCULAR DISEASEAna Diez Roux; Fiscal Year: 2002..The investigators point ut that the proposed study builds on existing cohort studies of cardiovascular disease to explore hypotheses relevant to understanding the factors contributing to SES differences in CVD risk. ..
- Tumor Markers and Recurrent Adenomas: A Follow-up StudyWei Zheng; Fiscal Year: 2006..This study is likely to provide valuable information for identifying high-risk adenoma patients for close surveillance and chemoprevention. ..
- Genetics of the Sodium-Lithium CountertransportAbraham Aviv; Fiscal Year: 2008..abstract_text> ..
- The neighborhood environment and drug use in NYCSandro Galea; Fiscal Year: 2007..This, coupled with our studies involving telephone interviews with 6,000+ New Yorkers is assurance that the aims of this study can be achieved. ..
- Alcohol use and the risk of HIV-1 infection in BotswanaGeorge Seage; Fiscal Year: 2005..If alcohol plays an important role in the sexual transmission of HIV in Botswana, this proposal will be essential in design and conduct of future HIV risk reduction interventions in Sub-Saharan Africa. ..
- DIET AND SOMATIC MUTATIONS IN COLON CANCERMARTHA OR MARTY SLATTERY; Fiscal Year: 2007..e. p53, K-ras, and microsatellite instability). Differences in colon and rectal tumors will be compared. Additionally data from rectal tumors will be combined with that from colon tumors to define disease pathways. ..
- PCR Screening for CMV in Umbilical Cord Blood Stem CellsChristopher Hillyer; Fiscal Year: 2003....
- LATINO MSM COMMUNITY INVOLVEMENT: HIV PROTECTIVE EFFECTSJesus Ramirez Valles; Fiscal Year: 2005....
- TREATMENT OF SLEEP APNEA IN THE ELDERLYAllan Pack; Fiscal Year: 2003..These data will give novel definitive information both about identification and treatment of sleep apnea in the elderly. ..
- Determinants of Venous Thromboembolism in Older PeopleRobert J Glynn; Fiscal Year: 2010..Results will help identify high-risk older people, and potentially modifiable behaviors that influence risk of ..
- Malt Liquor/Fortified Wine Use and Ethnicity in the U.S.Thomas Greenfield; Fiscal Year: 2003..Last, we will explore spacial relationships between heavy use and alcohol-related victimization in communities as well as existing alcohol policies. Results inform culturally appropriate health messages and policy development. ..
- Three-generation Human Study of Reproductive Effects of Marine Food ContaminantsPHILIPPE ADAM GRANDJEAN; Fiscal Year: 2010..Current evidence already suggests that these pathologies may already affect many populations, and the present proposal aims at identifying whether persistent organochlorine pollutants contribute to these abnormalities. ..
- SMOKING & GENETIC INTERACTION IN BREAST CANCER ETIOLOGYTimothy Lash; Fiscal Year: 2004..The second study would collect buccal swabs from participants in the study of adjuvant tamoxifen therapy (Dr. Silliman PI). A similar analytic plan would be conducted, but with a case-only design. ..
- Efficacy of Acupuncture in Treating Urinary IncontinenceSandra Engberg; Fiscal Year: 2009..abstract_text> ..
- Identification of Mulit-Drug Resistant HIV-1 IsolatesRobert Shafer; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- HEPATITIS C IN NEW IDUS: IMPLICATIONS FOR HIV PREVENTIONSandro Galea; Fiscal Year: 2004....
- The Epidemiology of Mood, Anxiety and Alcohol DisorderKenneth Kendler; Fiscal Year: 2004....
- Delphi Evaluation of Alcohol Advertising CodesThomas Babor; Fiscal Year: 2009..abstract_text> ..
- In silico genome scan with high-throughput addiction related phenotypes in miceEdwin van den Oord; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- 7th International Conference on Urban HealthDavid Vlahov; Fiscal Year: 2008..In particular, the environmental health impacts urbanization and urban areas affect a growing proportion of the world's population. [unreadable] [unreadable] [unreadable] [unreadable]..
- Spatio-Temporal Epidemiology: Methods and ApplicationsJonathan Wakefield; Fiscal Year: 2008..S. cancer incidence and mortality data, and Washington State small-area cancer incidence data. Developed methods will be made available to researchers via implementation within freely-available software. ..
- INFORMATION BASED DESIGN AND INTERIM MONITORING SOFTWARECyrus Mehta; Fiscal Year: 2002..2) Permit adaptive re-estimation of sample size, accrual period, total study duration and other design parameters, at each interim monitoring time-point using information-based monitoring. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE ..
- Sociocultural validity in the context of DSM comorbidityJanette Beals; Fiscal Year: 2008..This study has important public health implications as we move towards DSM-V, both for American Indian populations but also more generally, as we seek to improve the psychiatric diagnostic process. ..
- Correlates of Sexual Risk for HIV/STI Among Women Who Use MethamphetamineALEXANDER KRAL; Fiscal Year: 2008..The proposed study addresses an understudied and important public health issue: MA use among women. [unreadable] [unreadable] [unreadable]..
- Qualitative Exploration of Low-Frequency Heroin Injectors Not in Drug TreatmentALEXANDER KRAL; Fiscal Year: 2009..An in-depth assessment of low-FHI can inform treatment approaches and expand our knowledge base regarding variations in heroin use among urban poor populations. ..
- Early Childhood Development and PCB Exposures in Slovak*Irva Hertz Picciotto; Fiscal Year: 2005..Other unique features include the evaluation of hearing loss at birth, the measurement of hydroxy and methylsulfone metabolites of PCBs, and a population which includes about 1/3 Gypsies. ..
- Population Drinking Patterns & HIV Risk in Goa, IndiaThomas Greenfield; Fiscal Year: 2006..Risk analyses will inform the epidemiology of HIV risk behaviors in India and provide a rich source of information for planning preventive interventions in a resource-poor society. ..
- Estimating Neural Network Precision for Cancer DiagnosisYulei Jiang; Fiscal Year: 2003....
- STATISTICAL METHODS IN CANCER EPIDEMIOLOGYNorman Breslow; Fiscal Year: 2004..The methods used to achieve these goals include mathematical and statistical analysis, computer simulation and application to important datasets collected by cancer epidemiologists and other public health scientists. ..
- 'Costs & Effectiveness of Trauma Care in the Elderly'Ellen Mackenzie; Fiscal Year: 2004....
- International Society Environmental Epidemiology 2003Irva Hertz Picciotto; Fiscal Year: 2003..ISEE provides a variety of forums for discussion, critical reviews, collaborations and education issues for environmental exposures and their human health effects. ..
- COLLABORATIVE INITIAL GLAUCOMA TREATMENT STUDYRohit Varma; Fiscal Year: 2003....
- HIV Transmission in Russia Through Liquid Drug InjectionRobert Heimer; Fiscal Year: 2004....
- An Irish Affected Sib Pair Study of Alcohol DependenceKenneth Kendler; Fiscal Year: 2005..To conduct this project we have assembled a team of experts in clinical assessment, statistical genetics and molecular genetics...
- Mental health in NYC after WTC disasterDavid Vlahov; Fiscal Year: 2005..e., n=2000 for final cohort). We will use multivariable analyses and hierarchical modeling to address key research hypotheses in this proposal. ..
- ALCOHOL DEPENDENCE--GENERAL POPULATION VALIDITYDeborah Hasin; Fiscal Year: 2003..abstract_text> ..
- Axis I & Axis II Psychiatric Disorders in Norwegian TwinKenneth Kendler; Fiscal Year: 2007..This study has the capacity to address several key and largely unanswered empirical questions about PDs, the answers to which will be critical for proposed revisions in DSM-V. ..
- World Mental Health Consortium Annual Meeting 2003-07Steven Heeringa; Fiscal Year: 2007..abstract_text> ..
- Hormones and Cytokines in CaP risk and recurrenceMeir Stampfer; Fiscal Year: 2006..The large number of cases (n=1 ,765) will provide sufficient statistical power to provide firm answers to these questions. ..
- RAPID VACCINATION OF HARD TO REACH POPULATI0NSDavid Vlahov; Fiscal Year: 2006..Phase 3 of this project will identify the promising elements of the program and develop materials to allow generalizability to other urban areas and to other vaccines (e.g., HIV, HBV, etc). [unreadable] [unreadable]..
- Effects of perinatal endocrine disrupters in childrenPhilippe Grandjean; Fiscal Year: 2004..Modern statistical methods will be used to determine whether these outcome variables are associated with estrogen, thyroid, or Ah receptor abnormalities and specific contaminant exposures prenatally or postnatally. ..
- Model for differences in incontinence care seekingMichael Heit; Fiscal Year: 2002..abstract_text> ..
- Computational Statistic Approaches to Gene-Environment InteractionSEBASTIAN ZOELLNER; Fiscal Year: 2009..We intend to use this dataset as well as simulated datasets and other GWA datasets to evaluate and calibrate our methods for estimating genotype-phenotype interaction and for planning replication studies. (End of Abstract) ..
- Evaluating industry codes governing malt liquor adsThomas Babor; Fiscal Year: 2003....
- Novel Imaging to Predict Cardiovascular Events in DiabetesZahi A Fayad; Fiscal Year: 2010..It is our expectation that our data will be utilized to evaluate and improve existent treatment and develop effective new therapies to decrease the burden of atherosclerotic disease in diabetes. ..
- Osteoporosis in Women with Rheumatoid ArthritisDaniel Solomon; Fiscal Year: 2006..This epidemiologic data will inform future trials of osteoporosis treatments among patients with RA. As well, the study cohort will comprise one of the largest RA registries with an explicit plan to examine osteoporosis. ..
- Integrating Sex & Drug Related HIV Risk & TransmissionRobert Heimer; Fiscal Year: 2007..abstract_text> ..
- Evidence-Based Rheumatology: Prevalence/Impact ArthritisEdward Yelin; Fiscal Year: 2005..The conference will be one day in duration and will take place on November 12, 2005, the day preceding the formal opening of the Annual Meeting of the American College of Rheumatology. ..