sublingual administration

Summary

Summary: Administration of a soluble dosage form by placement under the tongue.

Top Publications

  1. ncbi Efficacy of sublingual specific immunotherapy in Cupressaceae allergy using an extract of Cupressus arizonica. A double blind study
    R Ariano
    Modulo di Allergologia ed Immunologia Clinica, A.S.L. Imperiese-Ospedale S. Charles di Bordighera, Italy
    Allergol Immunopathol (Madr) 29:238-44. 2001
  2. ncbi Monoid sublingual immunotherapy
    A G Palma-Carlos
    Clinical Allergy Immunology Center, CAIC, Lisbon, Portugal
    Eur Ann Allergy Clin Immunol 38:87-9. 2006
  3. ncbi Treatment of post-partum haemorrhage with sublingual misoprostol versus oxytocin in women not exposed to oxytocin during labour: a double-blind, randomised, non-inferiority trial
    Beverly Winikoff
    Gynuity Health Projects, New York, NY, USA
    Lancet 375:210-6. 2010
  4. ncbi Treatment of post-partum haemorrhage with sublingual misoprostol versus oxytocin in women receiving prophylactic oxytocin: a double-blind, randomised, non-inferiority trial
    Jennifer Blum
    Gynuity Health Projects, New York, NY 10010, USA
    Lancet 375:217-23. 2010
  5. ncbi Sublingual sugar administration as an alternative to intravenous dextrose administration to correct hypoglycemia among children in the tropics
    Hubert Barennes
    Centre Muraz, Bobo Dioulasso, Burkina Faso, France
    Pediatrics 116:e648-53. 2005
  6. ncbi The start of pharmacological activity after sublingual administration of sildenafil citrate in 30 patients affected by erectile dysfunction
    Mario De Siati
    Divisione di Urologia, Ospedale De Lellis, Via Camillo de Lellis, 36017 Schio, VI, Italy
    Arch Ital Urol Androl 75:18-20. 2003
  7. ncbi Optimal dose, efficacy, and safety of once-daily sublingual immunotherapy with a 5-grass pollen tablet for seasonal allergic rhinitis
    Alain Didier
    Department of Pneumology, Larrey Hospital, Toulouse, France
    J Allergy Clin Immunol 120:1338-45. 2007
  8. ncbi Assessment of sublingual immunotherapy efficacy in children with house dust mite-induced allergic asthma optimally controlled by pharmacologic treatment and mite-avoidance measures
    Nhan Pham-Thi
    Department of Paediatric Pneumology and Allergy, Hopital Necker Enfants Malades, Paris, France
    Pediatr Allergy Immunol 18:47-57. 2007
  9. pmc Pharmacokinetics and tolerability of different doses of fentanyl following sublingual administration of a rapidly dissolving tablet to cancer patients: a new approach to treatment of incident pain
    B Lennernas
    Department of Oncology, Karolinska Hospital, Stockholm, Sweden
    Br J Clin Pharmacol 59:249-53. 2005
  10. ncbi Safety of sublingual-swallow immunotherapy in children aged 3 to 7 years
    Alessandro Fiocchi
    Department of Child and Maternal Medicine, The Fatebenefratelli Melloni University Hospital, Milan, Italy
    Ann Allergy Asthma Immunol 95:254-8. 2005

Detail Information

Publications205 found, 100 shown here

  1. ncbi Efficacy of sublingual specific immunotherapy in Cupressaceae allergy using an extract of Cupressus arizonica. A double blind study
    R Ariano
    Modulo di Allergologia ed Immunologia Clinica, A.S.L. Imperiese-Ospedale S. Charles di Bordighera, Italy
    Allergol Immunopathol (Madr) 29:238-44. 2001
    ..SLIT with Cupressus arizonica appeared to be effective and safe in the treatment of Cupressaceae pollen respiratory allergy...
  2. ncbi Monoid sublingual immunotherapy
    A G Palma-Carlos
    Clinical Allergy Immunology Center, CAIC, Lisbon, Portugal
    Eur Ann Allergy Clin Immunol 38:87-9. 2006
    ..Monomeric allergoids are an efficace and safe immunotherapy in allergic rhinitis...
  3. ncbi Treatment of post-partum haemorrhage with sublingual misoprostol versus oxytocin in women not exposed to oxytocin during labour: a double-blind, randomised, non-inferiority trial
    Beverly Winikoff
    Gynuity Health Projects, New York, NY, USA
    Lancet 375:210-6. 2010
    ..This trial established whether sublingual misoprostol was similarly efficacious to intravenous oxytocin for treatment of post-partum haemorrhage in women not exposed to oxytocin during labour...
  4. ncbi Treatment of post-partum haemorrhage with sublingual misoprostol versus oxytocin in women receiving prophylactic oxytocin: a double-blind, randomised, non-inferiority trial
    Jennifer Blum
    Gynuity Health Projects, New York, NY 10010, USA
    Lancet 375:217-23. 2010
    ..This trial established whether sublingual misoprostol is non-inferior to intravenous oxytocin for treatment of post-partum haemorrhage in women receiving prophylactic oxytocin...
  5. ncbi Sublingual sugar administration as an alternative to intravenous dextrose administration to correct hypoglycemia among children in the tropics
    Hubert Barennes
    Centre Muraz, Bobo Dioulasso, Burkina Faso, France
    Pediatrics 116:e648-53. 2005
    ..A randomized, clinical trial was performed in Burkina Faso among moderately hypoglycemic children, comparing sublingual sugar administration with oral water, oral sugar, and dextrose infusion administrations...
  6. ncbi The start of pharmacological activity after sublingual administration of sildenafil citrate in 30 patients affected by erectile dysfunction
    Mario De Siati
    Divisione di Urologia, Ospedale De Lellis, Via Camillo de Lellis, 36017 Schio, VI, Italy
    Arch Ital Urol Androl 75:18-20. 2003
    ..We evaluated the start of pharmacological activity in 30 patients affected by non-psychogenic ED after sublingual administration of Sildenafil citrate.
  7. ncbi Optimal dose, efficacy, and safety of once-daily sublingual immunotherapy with a 5-grass pollen tablet for seasonal allergic rhinitis
    Alain Didier
    Department of Pneumology, Larrey Hospital, Toulouse, France
    J Allergy Clin Immunol 120:1338-45. 2007
    ..Sublingual immunotherapy is well tolerated and data suggest its effectiveness for the treatment of allergic rhinitis in adults, but it lacks optimum dose definition...
  8. ncbi Assessment of sublingual immunotherapy efficacy in children with house dust mite-induced allergic asthma optimally controlled by pharmacologic treatment and mite-avoidance measures
    Nhan Pham-Thi
    Department of Paediatric Pneumology and Allergy, Hopital Necker Enfants Malades, Paris, France
    Pediatr Allergy Immunol 18:47-57. 2007
    ..Under such conditions, only a complete, but ethically unfeasible, discontinuation of inhaled corticosteroid would have demonstrated a possible benefit of SLIT...
  9. pmc Pharmacokinetics and tolerability of different doses of fentanyl following sublingual administration of a rapidly dissolving tablet to cancer patients: a new approach to treatment of incident pain
    B Lennernas
    Department of Oncology, Karolinska Hospital, Stockholm, Sweden
    Br J Clin Pharmacol 59:249-53. 2005
    ..In this study, the pharmacokinetics of a novel sublingual dosage form of fentanyl developed for breakthrough pain was evaluated...
  10. ncbi Safety of sublingual-swallow immunotherapy in children aged 3 to 7 years
    Alessandro Fiocchi
    Department of Child and Maternal Medicine, The Fatebenefratelli Melloni University Hospital, Milan, Italy
    Ann Allergy Asthma Immunol 95:254-8. 2005
    ..The minimum age to start specific immunotherapy with inhalant allergens in children has not been clearly established, and position papers discourage its use in children younger than 5 years...
  11. ncbi Efficacy of sublingual immunotherapy with high-dose mite extracts in asthma: a multi-center, double-blind, randomized, and placebo-controlled study in Taiwan
    Chen Kuang Niu
    Division of Pediatric Pulmonology, Kaohsiung Chang Gung Children s Hospital, Department of Pediatrics, Medical College, Kaohsiung Medical University Hospital, Taiwan, ROC
    Respir Med 100:1374-83. 2006
    ..p. and D.f. Tolerance with high-dose SLIT was good with few minor adverse events reported. Our results indicated that a 24-week SLIT is of clinical benefit to mite-sensitive asthmatic children in Taiwan...
  12. ncbi Sublingual administration of fentanyl to cancer patients is an effective treatment for breakthrough pain: results from a randomized phase II study
    Bo Lennernas
    Sahlgrenska akademin, Goteborg University, Gothenburg, Sweden
    Palliat Med 24:286-93. 2010
    ..0146, SLF 400 microg) confirmed these differences as clinically important. Nausea and dizziness were the most common treatment-related adverse effects. SLF appears to be a fast, effective and well-tolerated treatment for BTP...
  13. ncbi Dose dependence of immunological response to sublingual immunotherapy
    F Marcucci
    Department of Obstetric, Gynaecologic and Pediatric Sciences, University of Perugia, Perugia, Italy
    Allergy 60:952-6. 2005
    ..We studied the dose dependence of clinical efficacy and immunological response to SLIT by administering two different dosages of the same allergen in rhinitic children monosensitized to grass pollen...
  14. ncbi Efficacy and safety of sublingual immunotherapy with grass allergen tablets for seasonal allergic rhinoconjunctivitis
    Ronald Dahl
    Department of Respiratory Diseases, Aarhus University Hospital, Aarhus, Denmark
    J Allergy Clin Immunol 118:434-40. 2006
    ..The sublingual route also has potential, although definitive evidence from large randomized controlled trials has been lacking...
  15. ncbi Effect of sublingual administration of interferon-alpha on the immune response to influenza vaccination in institutionalized elderly individuals
    Odile Launay
    Universite Paris Descartes, Faculte de Medecine, Paris, France
    Vaccine 26:4073-9. 2008
    A randomized double-blind placebo-controlled study was conducted to determine the effect of sublingual administration of IFNalpha on the immune response to influenza vaccination in elderly institutionalized individuals...
  16. ncbi Efficacy of sublingual immunotherapy in the treatment of allergic rhinitis in pediatric patients 3 to 18 years of age: a meta-analysis of randomized, placebo-controlled, double-blind trials
    Martin Penagos
    Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Italy
    Ann Allergy Asthma Immunol 97:141-8. 2006
    ..To evaluate the efficacy of sublingual immunotherapy (SLIT) in the treatment of allergic rhinitis in children...
  17. ncbi Comparison of oxycodone pharmacokinetics after buccal and sublingual administration in children
    Hannu Kokki
    Department of Anaesthesiology and Intensive Care, Kuopio University Hospital, Kuopio, Finland
    Clin Pharmacokinet 45:745-54. 2006
    We evaluated and compared the pharmacokinetics of two oral administration routes of oxycodone parenteral liquid (10 mg/mL)--single buccal and sublingual administration--in 30 generally healthy awake children, aged 6-91 months.
  18. ncbi Pharmacokinetics of different routes of administration of misoprostol
    Oi Shan Tang
    Department of Obstetrics and Gynaecology, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Hum Reprod 17:332-6. 2002
    ..The pharmacokinetic parameters of four different routes of administration of a single dose of 400 microg of misoprostol were studied...
  19. ncbi Economic evaluation of sublingual immunotherapy vs symptomatic treatment in adults with pollen-induced respiratory allergy: the Sublingual Immunotherapy Pollen Allergy Italy (SPAI) study
    Patrizia Berto
    School of Pharmacy, University of Padova, and PBE Consulting, Verona, Italy
    Ann Allergy Asthma Immunol 97:615-21. 2006
    ..Few data are available on the pharmacoeconomic aspects of immunotherapy...
  20. ncbi Sublingual immunotherapy for allergic rhinitis: systematic review and meta-analysis
    D R Wilson
    University Hospital Birmingham NHS Trust, Birmingham, UK
    Allergy 60:4-12. 2005
    ..Increasing duration of treatment does not clearly increase efficacy. The total dose of allergen administered may be important but insufficient data was available to analyse this factor...
  21. ncbi Noninjection routes for immunotherapy
    Giorgio Walter Canonica
    Division of Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Italy
    J Allergy Clin Immunol 111:437-48; quiz 449. 2003
    ..Although the long-lasting efficacy has been recently documented for the sublingual route, several points still need to be elucidated, including mechanisms of action, optimal dosage, cost-effectiveness, and adherence...
  22. ncbi Cost effectiveness of sublingual immunotherapy in children with allergic rhinitis and asthma
    P Berto
    pbe consulting, Verona, Italy
    Eur Ann Allergy Clin Immunol 37:303-8. 2005
    ..Aim of this study was to evaluate the economic effect of treatment with high dose sublingual immunotherapy (SLIT) in children...
  23. ncbi Efficacy of two intervals and two routes of administration of misoprostol for termination of early pregnancy: a randomised controlled equivalence trial
    Helena von Hertzen
    UNDP UNFPA WHO World Bank Special Programme of Research, Development and Research Training in Human Reproduction, Department of Reproductive Health and Research, WHO, Geneva, Switzerland
    Lancet 369:1938-46. 2007
    ..Our aim was to assess the effects of the interval between multiple doses of misoprostol and the route of administration to terminate pregnancy...
  24. ncbi The safety of sublingual-swallow immunotherapy: an analysis of published studies
    G B Gidaro
    Stallergènes, Scientific Department, Milan, Italy
    Clin Exp Allergy 35:565-71. 2005
    ..This aspect deserves particular mention when a higher dose of allergen extract than traditional subcutaneous immunotherapy (SCIT) is required to be effective: that may be up to 500 times that employed for SCIT...
  25. ncbi Post-marketing survey on the safety of sublingual immunotherapy in children below the age of 5 years
    V Di Rienzo
    Clinica Villa Benedetta, Rome, Italy
    Clin Exp Allergy 35:560-4. 2005
    ..Sublingual immunotherapy (SLIT) seems to be safe, but no study in very young children is available. We performed a safety post-marketing surveillance study in children below 5 years...
  26. ncbi Comparison of costs of sublingual immunotherapy and drug treatment in grass-pollen induced allergy: results from the SIMAP database study
    Patrizia Berto
    School of Pharmacy, University of Padova, Italy PBE Consulting, Verona, Italy
    Curr Med Res Opin 24:261-6. 2008
    ....
  27. ncbi Effect of sublingual administration with a native or denatured protein allergen and adjuvant CpG oligodeoxynucleotides or cholera toxin on systemic T(H)2 immune responses and mucosal immunity in mice
    Ching Feng Huang
    Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan
    Ann Allergy Asthma Immunol 99:443-52. 2007
    ..Sublingual immunotherapy has been recently used for allergic diseases, but its mechanisms are still unclear...
  28. ncbi Lack of inflammatory cells in the oral mucosa of subjects undergoing sublingual immunotherapy
    F Marcucci
    Pediatrics, University Department of Medical and Surgical Specialties and Public Health, Perugia, Italy
    Int J Immunopathol Pharmacol 21:609-13. 2008
    ....
  29. doi Immunotherapy in children and adolescents with allergic rhinoconjunctivitis: a systematic review
    Esther Röder
    Pediatr Allergy Immunol 19:197-207. 2008
    ..In conclusion, there is at present insufficient evidence that immunotherapy in any administration form has a positive effect on symptoms and/or medication use in children and adolescents with allergic rhinoconjunctivitis...
  30. ncbi Efficacy and safety of high-doses sublingual immunotherapy in ultra-rush scheme in children allergic to grass pollen
    I Stelmach
    Department of Pediatrics and Allergy, N Copernicus Hospital, 62 Pabianicka Street, Lodz, Poland
    Clin Exp Allergy 39:401-8. 2009
    ..Although sublingual immunotherapy (SLIT) has been used with increasing frequency, the data on the efficacy of SLIT in pediatric asthma are limited...
  31. ncbi Administration regimens for sublingual immunotherapy to pollen allergens: what do we know?
    C Lombardi
    Pneumoallergology Unit, S Orsola FBF Hospital, Brescia, Italy
    Allergy 64:849-54. 2009
    ..We review herein the available literature (randomized double blind controlled studies) on pollen SLIT, in order to derive experimentally-supported suggestions about the regimens of administration that should be preferred...
  32. ncbi Safety of sublingual immunotherapy started during the pollen season
    Renato Ariano
    Allergy Department, ASL1 Imperiese, Bordighera, Italy
    Curr Med Res Opin 25:103-7. 2009
    ..The aim of this study was to assess the safety of ultra-rush SLIT in pollen-allergic children according to different timing of administration in relation to the pollen season...
  33. pmc Misoprostol in addition to routine treatment of postpartum hemorrhage: a hospital-based randomized-controlled trial in Karachi, Pakistan
    Nadeem F Zuberi
    The Aga Khan University, Dept of Obstetrics and Gynecology, Karachi, Pakistan
    BMC Pregnancy Childbirth 8:40. 2008
    ..This study aimed to determine the adjunct benefit of misoprostol when combined with standard oxytocics for PPH treatment...
  34. ncbi Is sublingual immunotherapy clinically effective?
    Hans Jørgen Malling
    Allergy Clinic, National University Hospital, Copenhagen, Denmark
    Curr Opin Allergy Clin Immunol 2:523-31. 2002
    ....
  35. ncbi Sublingual immunotherapy in pollen-induced seasonal rhinitis and conjunctivitis: a randomized controlled trial
    R Mosges
    IMSIE Klinikum der Universität zu Köln, D 50924 Cologne, Germany
    Acta Dermatovenerol Alp Pannonica Adriat 16:143-8. 2007
    ..Sublingual immunotherapy (SLIT) is a recognized and safe treatment for allergic rhinitis and conjunctivitis. The aim was to evaluate the efficacy and safety of tablets for grass and rye pollen- induced rhinitis and conjunctivitis...
  36. ncbi Effects of sublingual immunotherapy for multiple or single allergens in polysensitized patients
    Maurizio Marogna
    Pneumology Unit, Cuasso al Monte, Macchi Hospital Foundation, Varese, Italy
    Ann Allergy Asthma Immunol 98:274-80. 2007
    ..Sublingual immunotherapy (SLIT) has proven efficacy in treating respiratory allergy...
  37. ncbi Randomized controlled trial of high-dose sublingual immunotherapy to treat seasonal allergic rhinitis
    Helen Smith
    Wessex Research Network, Primary Medical Care, University of Southampton, United Kingdom
    J Allergy Clin Immunol 114:831-7. 2004
    ..Seasonal allergic rhinitis is common and troublesome. Sublingual immunotherapy (SLIT) has been proposed as an alternative to injection immunotherapy and might offer some advantages if it were effective and practical in a community setting...
  38. ncbi Efficacy of grass pollen sublingual immunotherapy for three consecutive seasons and after cessation of treatment: the ECRIT study
    H Ott
    Department of Dermatology and Allergology, University Hospital of the Rheinisch Westfälische Technische Hochschule Aachen, Kamp Lintfort, Germany
    Allergy 64:1394-401. 2009
    ..This randomized, double-blind, placebo-controlled study evaluated the efficacy, carry-over effect and safety of grass pollen SLIT using co-seasonal treatment...
  39. ncbi A pilot study of feasibility of ultra-rush (20-25 minutes) sublingual-swallow immunotherapy in 679 patients (699 sessions) with allergic rhinitis and/or asthma
    R E Rossi
    Allergy Unit, National Health Service, Regione Piemonte, Italy
    Int J Immunopathol Pharmacol 18:277-85. 2005
    ....
  40. ncbi Pharmacokinetics of olanzapine after single-dose oral administration of standard tablet versus normal and sublingual administration of an orally disintegrating tablet in normal volunteers
    John S Markowitz
    Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, USA
    J Clin Pharmacol 46:164-71. 2006
    ..The homozygous TT genotype for P-gp resulted in an increased AUC of OLZ for SOT administration but not for either condition where sublingual absorption could occur...
  41. ncbi Safety and tolerability of ultra-rush induction, less than one hour, of sublingual immunotherapy in children
    S Tripodi
    Pediatric Allergy Unit, S Pertini Hospital, Rome, Italy
    Int Arch Allergy Immunol 139:149-52. 2006
    ..The aim of the present study was to evaluate the occurrence of immediate or late adverse reactions in allergic children after a very fast (40 min) ultra-rush SLIT induction with two different allergen extract solutions...
  42. ncbi Sublingual administration of Delta9-tetrahydrocannabinol/beta-cyclodextrin complex increases the bioavailability of Delta9-tetrahydrocannabinol in rabbits
    Janne Mannila
    Department of Pharmaceutical Chemistry, University of Kuopio, P O Box 1627, FIN 70211, Kuopio, Finland
    Life Sci 78:1911-4. 2006
    The bioavailability of Delta(9)-tetrahydrocannabinol (THC) was determined after its sublingual administration as solid THC/beta-cyclodextrin (THC/beta-CD) complex, and was compared to oral administration of ethanolic THC, in rabbits...
  43. ncbi [Vaccination against allergies yields good symptom relief]
    Gunilla Hedlin
    Astrid Lindgrens barnsjukhus, Karolinska Universitetssjukhuset Solna
    Lakartidningen 105:1938-41. 2008
  44. ncbi Comparison of the biological activity of the most common sublingual allergen solutions made by two European manufacturers
    Ralph Mosges
    Institute of Medical Statistics, Informatics, and Epidemiology, Medical Faculty, University of Cologne, Cologne, Germany
    Int Arch Allergy Immunol 139:325-9. 2006
    ..What is still lacking is a 'conversion rate' between the biological activities of different allergen solutions to determine the one with the higher concentration...
  45. ncbi Successful sublingual immunotherapy with birch pollen has limited effects on concomitant food allergy to apple and the immune response to the Bet v 1 homolog Mal d 1
    Tamar Kinaciyan
    Department of Dermatology, Division of Immunology, Allergy and Infectious Diseases, Center for Physiology and Pathophysiology, Medical University of Vienna, Austria
    J Allergy Clin Immunol 119:937-43. 2007
    ..Cross-reactivity between the major birch pollen allergen, Bet v 1, and the apple protein, Mal d 1, frequently causes food allergy...
  46. ncbi Specific immunotherapy with SQ standardized grass allergen tablets in asthmatics with rhinoconjunctivitis
    R Dahl
    Department of Respiratory Diseases, Aarhus University Hospital, Aarhus, Denmark
    Allergy 61:185-90. 2006
    ..As rhinoconjunctivitis often co-exists with asthma, we aimed to confirm safety and efficacy in grass allergic subjects with asthma and rhinoconjunctivitis...
  47. ncbi Safety of a SQ-standardised grass allergen tablet for sublingual immunotherapy: a randomized, placebo-controlled trial
    J Kleine-Tebbe
    Allergy and Asthma Center Westend, Berlin, Germany
    Allergy 61:181-4. 2006
    ..Sublingual treatment of grass pollen induced rhinoconjunctivitis might provide easier access to specific immunotherapy (SIT) and minimize the risk of serious adverse events (AEs) compared to subcutaneous SIT...
  48. ncbi Efficacy of sublingual coseasonal immunotherapy with a monomeric allergoid in Cupressaceae pollen allergy--preliminary data
    R Ariano
    U O Medicina Generale, Ospedale di Bordighera, A S L n 1, Imperiese
    Eur Ann Allergy Clin Immunol 37:103-8. 2005
    ..Respiratory allergy to conifers pollens is a growing phenomenon all over the world (Mediterranean area, USA, Japan). In France and Italy Cupressus sempervirens is the commonest offender...
  49. ncbi Absence of systemic immunologic changes during dose build-up phase and early maintenance period in effective specific sublingual immunotherapy in children
    E Dehlink
    Department of Pediatrics and Juvenile Medicine and Department of Pathophysiology, Centre for Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria
    Clin Exp Allergy 36:32-9. 2006
    ..Sublingual immunotherapy (SLIT) has been reported to be a safe treatment for inhalant allergies in children. Yet the immunologic mechanisms resulting in clinical improvement are poorly understood...
  50. ncbi Sublingual specific immunotherapy reduces PBMC proliferations
    D Fenoglio
    DIMI CEBR, Universita di Genova, Genoa, Italy
    Eur Ann Allergy Clin Immunol 37:147-51. 2005
    ..Subcutaneous specific immunotherapy has been demonstrated capable of inducing T regulatory response. There is few evidence concerning immunological changes induced by sublingual immunotherapy...
  51. ncbi Economic evaluation of sublingual immunotherapy: an analysis of literature
    G Ciprandi
    Dipartimento di malattie immuno allergologiche, Semeiotica Medica I, Ospedale Universitario S Martino, Genoa, Italy
    Eur Ann Allergy Clin Immunol 39:21-6. 2007
    ..The data obtained, although the number of studies is still limited, provide preliminary evidence supporting a SLIT effect on sparing costs for respiratory allergy...
  52. ncbi Allergen-induced in vitro expression of IL-18, SLAM and GATA-3 mRNA in PBMC during sublingual immunotherapy
    J Savolainen
    Department of Pulmonary Diseases and Clinical Allergology, University of Turku, Turku, Finland
    Allergy 62:949-53. 2007
    ..This study was undertaken to analyse the allergen induced in vitro mRNA expression of IL-18, SLAM and GATA-3 in peripheral blood mononuclear cells (PBMC) of children with allergic rhinitis (AR) during SLIT...
  53. ncbi Sublingual immunotherapy induces IL-10-producing T regulatory cells, allergen-specific T-cell tolerance, and immune deviation
    Barbara Bohle
    Department of Pathophysiology, Center for Physiology, Pathophysiology, and Immunology, Medical University of Vienna, Vienna, Austria
    J Allergy Clin Immunol 120:707-13. 2007
    ..The immunologic mechanisms underlying sublingual immunotherapy (SLIT) are still unclear, particularly the role of regulatory T cells...
  54. ncbi Practice parameters for sublingual immunotherapy
    C Ortolani
    Casa di Cura Ambrosiana, Cesano Boscone, Milan, Italy
    Monaldi Arch Chest Dis 65:44-6. 2006
    ..A duration of SLIT of 3-5 years is recommended to ensure a long-lasting clinical effect after the treatment has been terminated (grade C)...
  55. ncbi Quantitative assessment of the compliance with once-daily sublingual immunotherapy in children (EASY project: evaluation of a novel SLIT formulation during a year)
    Giovanni Passalacqua
    Allergy and Respiratory Diseases, DIMI, University of Genoa, Genoa, Italy
    Pediatr Allergy Immunol 18:58-62. 2007
    ..4%) for side effects probably related to therapy. These data obtained in a quite large sample of children and in real-life confirm that the compliance with SLITOne is good, despite the therapy managed at home...
  56. ncbi Sublingual immunotherapy with grass pollen is not effective in symptomatic youngsters in primary care
    Esther Röder
    Section of Allergology, Department of Internal Medicine, Erasmus MC Rotterdam, The Netherlands
    J Allergy Clin Immunol 119:892-8. 2007
    ..Most efficacy studies in children lack power to be conclusive, and all have been performed in referral centers...
  57. ncbi Evaluation of the antiinflammatory and clinical effects of sublingual immunotherapy with carbamylated allergoid in allergic asthma with or without rhinitis. A 12-month perspective randomized, controlled, trial
    S La Grutta
    Biomedicin and Molecular Immunology Institute, IBIM CNR, Palermo
    Eur Ann Allergy Clin Immunol 39:40-4. 2007
    ..Thus we decided to evaluate whether it can reduce the allergic inflammation and improve the clinical symptoms in comparison to pharmacotherapy...
  58. ncbi Cost-effectiveness of grass allergen tablet (GRAZAX) for the prevention of seasonal grass pollen induced rhinoconjunctivitis - a Northern European perspective
    C Bachert
    Upper Airway Research Laboratory URL, ENT Department, University Hospital, Ghent, Belgium
    Clin Exp Allergy 37:772-9. 2007
    ..The grass allergen tablet (GRAZAX) is a new allergen-specific immunotherapy for home administration...
  59. ncbi Long-term efficacy of sublingual immunotherapy in patients with perennial rhinitis
    Rauf Tahamiler
    Department of Otolaryngology, University of Istanbul, Cerrahpasa Medical School, Istanbul, Turkey
    Laryngoscope 117:965-9. 2007
    ..Sublingual immunotherapy has a documented clinical efficacy, but only a few long-term studies have been performed in people with perennial rhinitis...
  60. ncbi Immunoglobulin E and G antibody profiles to grass pollen allergens during a short course of sublingual immunotherapy
    W Aberer
    Department of Environmental Dermatology, Medical University of Graz, Graz, Austria
    J Investig Allergol Clin Immunol 17:131-6. 2007
    ..Various studies have shown the clinical efficacy of sublingual immunotherapy in grass pollen-induced rhinoconjunctivitis. However, even short-term treatment with grass extracts might cause sensitizations to formerly unrecognized antigens...
  61. ncbi Oral reactions to sublingual immunotherapy: a bioptic study
    F Marcucci
    Allergy Pulmonary rehabilitation, ICP Hospital, Via Bignami 1, 20100 Milan, Italy
    Allergy 62:1475-7. 2007
  62. ncbi Grass allergen tablet immunotherapy relieves individual seasonal eye and nasal symptoms, including nasal blockage
    S R Durham
    National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, London, UK
    Allergy 62:954-7. 2007
    ..Reported here are the effects of Grazax on individual eye and nasal symptoms...
  63. ncbi Prolonged preseasonal treatment phase with Grazax sublingual immunotherapy increases clinical efficacy
    M A Calderon
    Imperial College, National Heart and Lung Institute, London, UK
    Allergy 62:958-61. 2007
    ..Aims of the study: The influence of the duration of preseasonal treatment on clinical efficacy obtained within the grass pollen season was investigated...
  64. ncbi Sublingual-swallow immunotherapy with standardized 3-grass pollen extract: a double-blind, placebo-controlled study
    Frederic de Blay
    Departement de Pneumologie, Hôpital Lyautey, Hopitaux Universitaires de Strasbourg, Strasbourg, France
    Ann Allergy Asthma Immunol 99:453-61. 2007
    ..Sublingual immunotherapy (SLIT) is accepted as a safe and effective route for the treatment of grass pollen allergy, but clarification of its clinical and biological efficacy requires more study...
  65. ncbi Efficacy and tolerability of high dose sublingual immunotherapy in patients with rhinoconjunctivitis
    M Worm
    Allergie Centrum Charité, Klinik für Dermatologie und Allergologie Universitätsmedizin Berlin, Universitatsklinikum Charite, Charite Platz 1, D 10117 Berlin
    Eur Ann Allergy Clin Immunol 38:355-60. 2006
    ..The treatment with the sublingual solution was well tolerated. High dose sublingual immunotherapy can therefore be considered as an efficient therapeutic option in the management of IgE-mediated allergic airway diseases...
  66. ncbi Randomized double-blind controlled study with sublingual carbamylated allergoid immunotherapy in mild rhinitis due to mites
    G Passalacqua
    Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Genoa, Italy
    Allergy 61:849-54. 2006
    ..The clinical efficacy of sublingual immunotherapy (SLIT) in mite allergy and in mild disease is still a matter of debate, thus we performed a long-term clinical trial...
  67. ncbi [Allergic rhinitis. This year the pollen count is expected to be high]
    Andreas Hellmann
    MMW Fortschr Med 148:51-2. 2006
  68. ncbi Sublingual-oral administration of standardized allergenic extracts: phase 1 safety and dosing results
    Robert E Esch
    Research and Development, Greer Laboratories, Lenoir, North Carolina 28645, USA
    Ann Allergy Asthma Immunol 100:475-81. 2008
    ..European studies provide a preponderance of evidence for sublingual allergen immunotherapy (SLIT) safety and efficacy, but they use allergen products that differ from those expected to be approved in the United States...
  69. doi Sublingual immunotherapy for hazelnut food allergy: a follow-up study
    Ernesto Enrique
    Ann Allergy Asthma Immunol 100:283-4. 2008
  70. ncbi Clinical and immunologic effects of sublingual immunotherapy in asthmatic children sensitized to mites: a double-blind, randomized, placebo-controlled study
    Ko Huang Lue
    Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan
    Pediatr Allergy Immunol 17:408-15. 2006
    ..The clinical usefulness of this form of immunotherapy and the mechanism underlying its immunologic effects deserve further studies...
  71. ncbi Efficacy and safety of specific immunotherapy with a high-dose sublingual grass pollen preparation: a double-blind, placebo-controlled trial
    Oliver Pfaar
    Rhinology and Allergology Center, Wiesbaden, Germany
    Ann Allergy Asthma Immunol 100:256-63. 2008
    ..Sublingual immunotherapy (SLIT) is increasingly being used for the treatment of allergic rhinitis, but there are conflicting study results demonstrating clinically relevant efficacy...
  72. ncbi Safety and tolerability of grass pollen tablets in sublingual immunotherapy--a phase-1 study
    T H Larsen
    Allergy Clinic, National University Hospital, Copenhagen, Denmark
    Allergy 61:1173-6. 2006
    ..A single-centre, randomized, double-blind, placebo-controlled study. Aims: To compare the safety and tolerability of four different sublingual immunotherapy (SLIT) regimes in grass pollen allergic rhinitis...
  73. ncbi Sublingual immunotherapy in children modulates allergen-induced in vitro expression of cytokine mRNA in PBMC
    J Savolainen
    Department of Pulmonary Diseases and Clinical Allergology, University of Turku, Turku, Finland
    Allergy 61:1184-90. 2006
    ..Few data to date is available on mechanisms and roles of these cytokines in sublingual immunotherapy (SLIT)...
  74. ncbi An extract of Timothy-grass pollen used as sublingual immunotherapy for summer hay fever
    A B Kay
    Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College, London, UK
    Drugs Today (Barc) 43:841-8. 2007
    ..There have been no instances of anaphylaxis. In randomized double-blind placebo controlled trials Grazax reduces symptoms and medication scores in adults with hay fever. The long-term effects of Grazax are currently being investigated...
  75. ncbi Safety of specific sublingual immunotherapy with SQ standardized grass allergen tablets in children
    Maria Dolores Ibañez
    Servicio de Alergia, Hospital Universitario Nino Jesus, Madrid, Spain
    Pediatr Allergy Immunol 18:516-22. 2007
    ..The subjects recovered completely from the events. In conclusion, in the present study, Grazax was in general tolerated in a paediatric population and considered suitable for further clinical investigations in children...
  76. ncbi Sublingual specific immunotherapy for adults and children: a post-marketing surveillance study
    K J Drachenberg
    Bencard Allergie GmbH, Munich, Germany
    Allergol Immunopathol (Madr) 32:76-81. 2004
    ..We describe the results of treatment with a SLIT vaccine formulated with a range of allergen extracts obtained by allergologists in daily clinical practice...
  77. ncbi A pre-seasonal birch/hazel sublingual immunotherapy can improve the outcome of grass pollen injective treatment in bisensitized individuals. A case-referent, two-year controlled study
    A M Cirla
    Istituti Ospitalieri, Center for Environmental Allergy, Cremona, Italy
    Allergol Immunopathol (Madr) 31:31-43. 2003
    ..The study tests the hypothesis of a reduction of priming due to tree allergy in patients sensitised to both birch/hazel and grass pollen undergoing an associated preseasonal Sublingual/Injective immunotherapy...
  78. ncbi Sublingual immunotherapy in the context of a clinical practice improvement program in the allergological setting: results of a long-term observational study
    M Marogna
    Rehabilitative Pneumology Unit, Cuasso al Monte P O, Fondazione Macchi Hospital, Varese Italy
    Eur Ann Allergy Clin Immunol 35:133-40. 2003
    ....
  79. ncbi The efficacy of sublingual immunotherapy for respiratory allergy is not affected by different dosage regimens in the induction phase
    R Sambugaro
    ASL 12, Pavia, Italy
    Allergol Immunopathol (Madr) 31:329-37. 2003
    b>Sublingual administration of allergens is a safe and effective alternative to subcutaneous immunotherapy in patients with respiratory allergies...
  80. ncbi Clinical efficacy of microencapsulated timothy grass pollen extract in grass-allergic individuals
    Elizabeth C TePas
    Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, California, USA
    Ann Allergy Asthma Immunol 92:25-31. 2004
    ..It differs from other pharmacotherapies in that it can induce long-term clinical remission of these diseases. However, it requires years of treatment and is associated with serious allergic reactions...
  81. ncbi A double-blind placebo-controlled evaluation of sublingual immunotherapy with a standardized ragweed extract in patients with seasonal rhinitis. Evidence for a dose-response relationship
    C Andre
    Département Scientifique et Médical, Stallergènes S A, Antony, France
    Int Arch Allergy Immunol 131:111-8. 2003
    ..There is a growing consensus on the benefits of sublingual-swallow immunotherapy in the treatment of allergic diseases...
  82. ncbi [Sublingual immunotherapy in children. Immunotherapy Committee of the Spanish Society for Clinical Immunology and Pediatric Allergology]
    R Lleonart
    Comité de Inmunoterapia de la Sociedad Española de Inmunología Clínica y Alergología Pediátrica SEICAP, Barcelona, Spain
    Allergol Immunopathol (Madr) 31:244-9. 2003
    ..Finally, sublingual immunotherapy could be used in children who have shown systemic reactions to subcutaneous immunotherapy or who refuse to undergo injections...
  83. ncbi Efficacy of sublingual immunotherapy in grass pollen allergy
    Dirk Wessner
    Private Practice, Stuttgart, Technical University Munich, Munich, Germany
    Chem Immunol Allergy 82:53-61. 2003
    ..Effectiveness in preventing the onset of allergic asthma in patients with allergic rhinitis has been demonstrated for SIT, while for SLIT this question cannot yet be answered...
  84. ncbi Double-blind, placebo-controlled study with sublingual immunotherapy in children with seasonal allergic rhinitis to grass pollen
    B Wuthrich
    Allergy Unit, Department of Dermatology, University Hospital, Zurich, Switzerland
    J Investig Allergol Clin Immunol 13:145-8. 2003
    ..The purpose of this study was to assess the efficacy and tolerance of SLIT in children who are sensitized to grass pollen...
  85. ncbi Variation of the skin end-point in patients treated with sublingual specific immunotherapy
    V Bordignon
    Cittadella Hospital, Cittadella, Padua, Italy
    J Investig Allergol Clin Immunol 13:170-6. 2003
    ..001) and a higher rate of both no use of any drug (p = 0.013) and of at least a 50% reduction of the yearly duration of drug intake (p = 0.001) as compared to patients treated with three allergen administrations per week...
  86. ncbi Clinical efficacy of sublingual and subcutaneous birch pollen allergen-specific immunotherapy: a randomized, placebo-controlled, double-blind, double-dummy study
    M S Khinchi
    Allergy Clinic, National University Hospital, Copenhagen, Denmark
    Allergy 59:45-53. 2004
    ..Both sublingual allergen-specific immunotherapy (SLIT) and subcutaneous immunotherapy (SCIT) have a documented clinical efficacy, but only few comparative studies have been performed...
  87. ncbi Impact of sublingual immunotherapy on seasonal asthma and skin reactivity in children allergic to Parietaria pollen treated with inhaled fluticasone propionate
    G B Pajno
    Paediatric Clinic, Messina Polyclinic Hospital, Messina University, Messina, Italy
    Clin Exp Allergy 33:1641-7. 2003
    ..Immunotherapy is a recognized treatment for allergic respiratory diseases...
  88. ncbi [Sublingual vs subcutaneous immunotherapy]
    Alfonso Olivé Pérez
    Institut Català de la Salud, CAP Besos, Barcelona, Espana
    Rev Alerg Mex 51:29-35. 2004
    ..At the end of the 1980 decade, the first reports about the use of oral and sublingual routes of immunotherapy were published. This article reviews some reports comparing sublingual vs subcutaneous immunotherapy...
  89. ncbi [Sublingual immunotherapy with cat epithelial extract. Personal experience]
    A Sanchez Palacios
    Unidad de Alergologia, Hospital Universitario Insular de Gran Canaria, Las Palmas de Gran Canaria
    Allergol Immunopathol (Madr) 29:60-5. 2001
    ..4. In general, tolerance was good, except in one patient who presented urticaria and sublingual pruritus. 5. In polysensitized patients, sublingual immunotherapy to cat epithelium is complementary to immunotherapy to dermatophagoides...
  90. ncbi A prospective, randomized, double-blind, placebo-controlled multi-centre study on the efficacy and safety of sublingual immunotherapy (SLIT) in children with seasonal allergic rhinoconjunctivitis to grass pollen
    C Rolinck-Werninghaus
    Department of Pediatric Pneumology and Immunology, Charite, Berlin, Germany
    Allergy 59:1285-93. 2004
    ..Especially in childhood, sublingual immunotherapy (SLIT) could offer advantages over subcutaneous therapy. However, limited data on its efficacy is available...
  91. ncbi Randomized controlled open study of sublingual immunotherapy for respiratory allergy in real-life: clinical efficacy and more
    M Marogna
    Pneumology Unit, Cuasso al Monte, Macchi Hospital Foundation, Varese, Italy
    Allergy 59:1205-10. 2004
    ..We attempted to clarify these points in a randomized open, controlled, two parallel group study in a real-life setting...
  92. ncbi Kinetics and dynamic evaluation of specific immunotherapy
    C Pereira
    Immunoallergology Department, Coimbra University Hospital, Pneumology Center, Coimbra University, Portugal
    Eur Ann Allergy Clin Immunol 36:375-86. 2004
    ..We decided to study the in vivo kinetics of this therapy, using a nuclear medicine approach (leukocytes labelled with 99mTc-HMPAO) in patients on maintenance doses of specific immunotherapy with confirmed clinical efficacy...
  93. ncbi Cervical preparation for first trimester surgical abortion
    Nathalie Kapp
    Department of Reproductive Health and Research, World Health Organization, 20 Rue Appia, Geneva 27, Switzerland, CH 1211
    Cochrane Database Syst Rev 2:CD007207. 2010
    ..with significantly greater initial cervical dilation and lower rates of side-effects; however, sublingual administration 2-3 hours prior to the procedure demonstrated cervical effects superior to vaginal administration...
  94. ncbi Buprenorphine/naloxone: a review of its use in the treatment of opioid dependence
    Jennifer S Orman
    Wolters Kluwer Health, Adis, Auckland, New Zealand
    Drugs 69:577-607. 2009
    ..Moreover, buprenorphine/naloxone is a generally well tolerated medically-supervised withdrawal and maintenance treatment. Thus, sublingual buprenorphine/naloxone is a valuable pharmacotherapy for the treatment of opioid dependence...
  95. ncbi Nitric oxide donors in pregnancy: fetomaternal hemodynamic effects induced in mild pre-eclampsia and threatened preterm labor
    G Luzi
    Department of Obstetrics, Gynecology and Pediatrics, University of Perugia, Italy
    Ultrasound Obstet Gynecol 14:101-9. 1999
    ..Glyceryl trinitrate is able to release nitric oxide (NO); deficiency of NO has been hypothesized in the pathogenesis of pre-eclamptic disorders...
  96. ncbi [Ultrasonographic evaluation of atherosclerotic changes in carotid and brachial arteries in obese and hypertensive children]
    Joanna Tołwińska
    II Klinika Chorób Dzieci Akademii Medycznej w Białymstoku
    Przegl Lek 62:1346-51. 2005
    ..We measured the intimal plus medial thickness in carotid common arteries (IMT) also...
  97. ncbi Randomized, double-blind, placebo-controlled study of supplemental vitamin E on attenuation of the development of nitrate tolerance
    H Watanabe
    Department of Cardiology, KINU Medical Association Hospital, Mitsukaido, Japan
    Circulation 96:2545-50. 1997
    ..We investigated the preventive effect of an antioxidant, vitamin E, on the development of nitrate tolerance...
  98. ncbi The effect of a nitric oxide donor on fetal heart rate patterns in patients with hypertension
    Israel Thaler
    Department of Obstetrics and Gynecology, Rambam Medical Center, Haifa, Israel
    Obstet Gynecol 100:987-91. 2002
    ..To estimate whether nitric oxide donors can be administered safely to patients with pregnancy-associated hypertension based on computer analysis of antepartum fetal heart rate (FHR) tracings...
  99. ncbi Acute administration of 17beta-estradiol reduces endothelin-1 release during pacing-induced ischemia
    Giuseppe M C Rosano
    Cardiovascular Research Unit, IRCCS San Raffaele Roma, Via della Pisana, 235 00163, Roma, Italy
    Int J Cardiol 116:34-9. 2007
    ..To assess whether acute administration of 17beta-estradiol reduces pacing-induced cardiac release of endothelin-1 in female menopausal patients with coronary artery disease...
  100. ncbi Oral mucosal drug delivery: clinical pharmacokinetics and therapeutic applications
    Hao Zhang
    Cephalon, Inc, Salt Lake City, Utah 84116, USA
    Clin Pharmacokinet 41:661-80. 2002
    ..Studies of sublingual administration of estrogen are needed to clarify the most beneficial regimen...
  101. ncbi Tilt testing in neurocardiogenic syncope: isosorbide versus isoproterenol
    A G Hermosillo
    Department of Electrophysiology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico
    Acta Cardiol 55:351-5. 2000
    ..isoproterenol infusion at 4 microg/min (ISOP HUT), for 10 minutes, and, subsequently, were tilted after sublingual administration of 5 mg of isosorbide dinitrate (ISDN HUT) for another 12 minutes...

Research Grants29

  1. Clinical advancement of RDC-0313-buprenorphine: a novel approach to opioid recep
    RYAN TURNCLIFF; Fiscal Year: 2012
    ..A drug-drug interaction study of buprenorphine co-administered with and without sublingual administration of RDC-0313 is underway in collaboration with NIDA to determine the safety and tolerability of the co-..
  2. Effect of blood flow pattern on endothelial damage
    JOAQUIN GONZALES; Fiscal Year: 2007
    ..Endothelial dilatory function will be assessed by measuring peak reactive hyperemia and sublingual administration of nitroglycerin...
  3. Human Laboratory Model of Cocaine Treatment: Behavioral Economic Analysis
    Mark K Greenwald; Fiscal Year: 2010
    ....
  4. Sustained-Release Naltrexone for Opioid Dependence: Longitudinal Study in Humans
    Sandra D Comer; Fiscal Year: 2010
    ....
  5. Reducing Cocaine/Heroin Abuse with SR-Amphetamine and Buprenorphine
    Mark Greenwald; Fiscal Year: 2009
    ..The innovative aims, rigorous methods and clinical/public health significance of this project (i.e. whether SR-AMP has potential efficacy for reducing cocaine use) is highly concordant with this RFA. ..
  6. BUPRENORPHINE ABUSE BY HUMANS--LABORATORY STUDIES
    Sandra Comer; Fiscal Year: 2002
    ....
  7. Ab Alphavirus Replicon Vaccine against Cytomegalovirus
    Robert Esch; Fiscal Year: 2005
    ..PROPOSED COMMERCIAL APPLICATIONS: An effective CMV vaccine will prevent mental retardation and hearing loss associated with congenital CMV disease, thereby addressing an important unmet public health problem. ..
  8. PAIN AND ANALGESIC RESPONSE--SEX AND HORMONE VARIATIONS
    Sandra Comer; Fiscal Year: 2002
    ..In addition, they will more carefully examine sex differences in analgesic response to butorphanol and morphine, two agonists with differing selectivities for mu and kappa opioid receptors. ..
  9. DAYTIME SLEEPINESS--PREVALENCE, CONSEQUENCES, AND RISKS
    Thomas Roth; Fiscal Year: 2003
    ..The important contribution of the present proposal is that it will be the first population-based study to use laboratory assessments, its consequences and risks to measure sleepiness. ..
  10. CLINICAL RESEARCH ON DRUG ABUSE
    ERIC STRAIN; Fiscal Year: 2006
    ..Thus, this ISA represents a good investment by NIDA. ..
  11. Periodontal Disease and Rheumatoid Arthritis
    Michael McCracken; Fiscal Year: 2005
    ..Furthermore, it is hypothesized that among patients with rheumatoid arthritis, an association exists between the rate of progression of inflammatory arthritis and the progression of periodontal disease. ..
  12. Cost and Adherence in Drug Abuse Treatment
    KENNETH STOLLER; Fiscal Year: 2007
    ..This accomplishment will document my transition to the status of an independent patient-oriented researcher and recognized expert in the field of drug abuse treatment. [unreadable] [unreadable] [unreadable] [unreadable]..
  13. Effect of Diabetes on Bone Integration of Implants
    Michael McCracken; Fiscal Year: 2002
    ..This knowledge may lead to bioengineered materials which will modify and improve bone healing response in diabetic patients who receive implants. ..
  14. Chlipoplex Nanoparticle Prophylactics for RSV Infection
    Shyam Mohapatra; Fiscal Year: 2004
    ..abstract_text> ..
  15. Tobacco Use in Opioid Agonist treated Pregnant Women
    Hendree Jones; Fiscal Year: 2008
    ..This project will make substantial contributions to the understanding of tobacco use and cessation in pregnant women and the role tobacco has on the incidence and severity of NAS in methadone-maintained women. ..
  16. Maternal Opioid Treatment: Human Experimental Research
    Hendree Jones; Fiscal Year: 2008
    ..abstract_text> ..
  17. EVALUATION OF OPIOID ANTAGONIST ACTIVITY IN HUMANS
    Eric C Strain; Fiscal Year: 2010
    ....
  18. Counseling for Primary Care Office-Based Buprenorphine
    David Fiellin; Fiscal Year: 2009
    ..The results of this study will help define the role of professional evidence-based drug counseling in expanding access to treatment with Bup. ..
  19. Chitosan IFNgamma-pDNA Nanosphere Therapy and Immunopathology of Allergic Asthma
    Shyam Mohapatra; Fiscal Year: 2006
    ..It is anticipated that the results of these studies will contribute significantly to our knowledge of asthma and CIN therapy may provide a major breakthrough in management of asthma. ..
  20. SEROTONIN Treatment of Cocaine Dependence
    ERIC STRAIN; Fiscal Year: 2005
    ....
  21. Chliposome IFN-gamma-pDNA Naoparticle Therapy for Asthma
    Shyam Mohapatra; Fiscal Year: 2004
    ..The results of the proposed research are expected to advance our knowledge of the mechanisms of asthma and may lead to the development of an effective approach for the prevention and/or treatment of asthma. ..
  22. IMMUNOTHERAPY FOR PATIENTS WITH PEANUT ANAPHYLAXIS
    ARVIL BURKS; Fiscal Year: 2003
    ..abstract_text> ..
  23. METHADONE AND BUPERNORPHINE: ANTE- AND POST-PARTUM
    Hendree Jones; Fiscal Year: 2002
    ..abstract_text> ..
  24. CONTINGENCY MANAGEMENT FOR REAL-LIFE DRUG TREATMENT
    Leslie Amass; Fiscal Year: 2004
    ..Overall, these studies will guide practitioners in the use of CM for real-life drug abuse treatment. ..
  25. Treating the Partners of Drug Using Preg Women: Stage II
    Hendree Jones; Fiscal Year: 2007
    ..abstract_text> ..
  26. Immunotherapy for Peanut Allergy
    ARVIL BURKS; Fiscal Year: 2007
    ..The significance of this proposal is that if peanut SLIT in peanut allergic patients is effective, the treatment would provide an immediate therapeutic option for patients. ..
  27. Soy Immunotherapy for Patients with Peanut Anaphylaxis
    ARVIL BURKS; Fiscal Year: 2004
    ..If soybean IT in peanut allergic patients is effective, the treatment would provide an immediate therapeutic option. ..
  28. EXTRAMURAL RES FACILITIES CONSTR PROJ
    ARVIL BURKS; Fiscal Year: 2002
    ....
  29. IMMUNE MECHANISMS OF MIDDLE EAR DISEASE
    David Skoner; Fiscal Year: 2006
    ..The primary hypothesis is that cytokine genotype is predictive of illness expression and of OM incidence during a documented RSV infection in young children. ..